CN111721953A - Incubation groove component of biochemical analyzer and biochemical analysis method - Google Patents

Incubation groove component of biochemical analyzer and biochemical analysis method Download PDF

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Publication number
CN111721953A
CN111721953A CN201910215646.4A CN201910215646A CN111721953A CN 111721953 A CN111721953 A CN 111721953A CN 201910215646 A CN201910215646 A CN 201910215646A CN 111721953 A CN111721953 A CN 111721953A
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linear channel
biochemical
detection
biochemical analyzer
incubation
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CN201910215646.4A
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Inventor
石振希
时冉
王东元
武通园
叶友军
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Shenzhen Huoshui Bedside Diagnostic Instrument Co ltd
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Shenzhen Huoshui Bedside Diagnostic Instrument Co ltd
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Priority to CN201910215646.4A priority Critical patent/CN111721953A/en
Publication of CN111721953A publication Critical patent/CN111721953A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0432—Sample carriers adapted for special purposes integrated with measuring devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0434—Sample carriers adapted for special purposes in the form of a syringe or pipette tip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0437—Cleaning cuvettes or reaction vessels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
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  • Food Science & Technology (AREA)
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  • Biotechnology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention belongs to the technical field of biochemical analyzers, and provides an incubation groove component of a biochemical analyzer, wherein a puncture position and a sample adding position which are communicated with a linear channel are arranged on the incubation groove with the linear channel at intervals along the direction of the linear channel, a detection position which is communicated with the linear channel is arranged on the side surface of the incubation groove, and a driving mechanism which can drive a chip box internally sealed with a disposable test reagent to pass is arranged on one side of the linear channel, so that the problems of the effective period of bottle opening and the operation of a 'calibration' process are effectively avoided, and the detection process of the biochemical detector with the incubation groove component is instant and simple, and the detection precision is improved.

Description

Incubation groove component of biochemical analyzer and biochemical analysis method
Technical Field
The invention belongs to the technical field of biochemical analyzers, and particularly relates to an incubation tank assembly of a biochemical analyzer and a biochemical analysis method.
Background
At present, a circular ring-shaped incubation groove is commonly used in biochemical detectors to place a reagent bottle and a reaction cup. Wherein, the reagent bottle is filled with a plurality of human reagent quantities for detecting a plurality of samples. When a specific sample is detected, the reagent bottle is opened, and then the reagent is sucked by the reagent sucking device to be uniformly mixed with the sample in the reaction cup for detection.
Disclosure of Invention
Although the circular ring-shaped incubation groove of the existing biochemical detector can realize sample detection, the circular ring-shaped incubation groove is required to be capable of placing a plurality of reaction cups and reagent bottles containing a large amount of reagent for measurement so as to meet the requirement of multi-part test because the market orientation of the existing biochemical detector with the circular ring-shaped incubation groove is generally oriented to large medical institutions. However, practice shows that the reagent can not be used up after the reagent bottle is opened, so that the problem of bottle opening validity period is caused, namely, the reagent remained after the bottle is opened is reused after a certain time, and the sample detection precision can be reduced. In addition, the independent presence of the cuvettes and reagent bottles in the annular incubation chamber is often a significant reason for the need for complex "calibration" procedures for sample testing. The calibration requires professional operation and the operation flow is complex, so that the biochemical analyzer of the annular incubation groove cannot be popularized in small medical institutions such as community hospitals.
In conclusion, the circular ring-shaped incubation groove of the existing biochemical detector has the defects of complex detection process of the biochemical detector, easy reduction of detection precision and the like.
The invention provides an incubation groove component of a biochemical analyzer, which aims to solve the defects of the annular incubation groove of the existing biochemical detector, and comprises:
an incubation tank with a linear channel inside; a puncture position and a sample adding position which are communicated with the linear channel are arranged on the incubation groove at intervals along the direction of the linear channel; the side surface of the incubation groove is provided with a detection position communicated with the linear channel for biochemical detection; and one side of the linear channel is provided with a driving mechanism capable of driving the chip box internally sealed with the disposable test reagent to pass.
Further, the driving mechanism drives the chip box to pass by driving a clamping and limiting mechanism to move.
Furthermore, the clamping and limiting mechanism comprises a limiting block and a front sliding block and a rear sliding block which are connected through a spring; the limiting block limits the chip box; one side of the front and rear sliding blocks is provided with a rotary hook capable of rotatably clamping the chip box, and one side of the front and rear sliding blocks is connected with the driving mechanism.
Further, the incubation tank is of a strip structure.
Further, an in-place sensor for sensing position information of the chip cartridge is further provided at one side of the incubation slot.
Further, the in-position sensor is disposed near an entrance of the cartridge in the linear channel.
Further, the piercing location is further from the cartridge inlet of the linear channel than the sample loading location is from the cartridge inlet of the linear channel.
Furthermore, a chip box identification position is arranged on one side of the incubation groove; the chip box identification position is communicated with the linear channel, and the distance between the chip box identification position and the linear channel is longer than the distance between the puncture position and the chip box inlet of the linear channel.
Further, the detection position is arranged between the chip box identification position and the puncture position and comprises a transmission detection position and/or a scattering detection position.
In addition, the present invention provides a biochemical analysis method comprising:
a puncture position and a sample adding position which are communicated with the linear channel are arranged on the incubation groove with the linear channel at intervals along the direction of the linear channel;
arranging a detection position communicated with the linear channel on the side surface of the incubation groove for biochemical detection;
and a driving mechanism capable of driving the chip box internally sealed with the disposable test reagent to pass is arranged on one side of the linear channel.
The invention provides an incubation groove component of a biochemical analyzer, wherein a puncture position and a sample adding position which are communicated with a linear channel are arranged on the incubation groove with the linear channel at intervals along the direction of the linear channel, a detection position which is communicated with the linear channel is arranged on the side surface of the incubation groove, and a driving mechanism which can drive a chip box internally sealed with a disposable test reagent to pass is arranged on one side of the linear channel, thereby effectively avoiding the generation of the problem of the effective period of bottle opening and the operation of a 'calibration' process, and further leading the detection process of the biochemical detector with the incubation groove component to be instant and simple and improving the detection precision.
Drawings
FIG. 1 is a schematic diagram of an embodiment of an incubator assembly of a biochemical analyzer;
FIG. 2 is a schematic view showing the construction of an incubator assembly of a biochemical analyzer according to a modified embodiment;
FIG. 3 is a schematic view showing the construction of an incubator assembly of a biochemical analyzer according to a modified embodiment;
FIG. 4 is a process flow diagram of a method of a biochemical analyzer according to an embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Furthermore, in the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two elements may be directly connected or indirectly connected through an intermediate medium, or may be communicated with each other inside the two elements, or may be wirelessly connected or wired connected. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Furthermore, the technical features mentioned in the different embodiments of the invention described later can be combined with each other as long as they do not conflict with each other.
In the following, the present invention proposes some preferred embodiments to teach those skilled in the art to implement.
FIG. 1 is a schematic structural view of an incubator assembly of a biochemical analyzer according to an embodiment, showing an incubator assembly of a biochemical analyzer, the incubator assembly of the biochemical analyzer including:
referring to fig. 1, an incubation well 205 having a linear channel therein; a puncture position 2052 and a sample adding position 2051 which are communicated with the linear channel are arranged on the upper surface of the incubation groove 205 at intervals along the direction of the linear channel; the side surface of the incubation groove 205 is provided with detection positions (2054, 2055) communicated with the linear channel for biochemical detection; one side of the linear channel is provided with a driving mechanism 203 which can drive a chip box 204 filled with disposable test reagents to pass through.
In this embodiment, the puncturing positions 2052 and the sample adding positions 2051 communicated with the linear channel are arranged on the incubation groove 205 with the linear channel at intervals along the direction of the linear channel, the detection positions (2054, 2055) communicated with the linear channel are arranged on the side surface of the incubation groove 205, and the driving mechanism 203 capable of driving the chip box 204 internally sealed with the disposable test reagent to pass is arranged on one side of the linear channel, so that the problems of the effective period of the decapsulation and the operation of the 'calibration' process are effectively avoided, and the detection process of the biochemical detector with the incubation groove 205 assembly is instant and simple and the detection precision is improved.
It should be noted that, because the testing reagent sealed in the chip box 204 is a disposable reagent for a single person, the testing reagent is sealed in the chip box 204 in advance through the sealing film for disposable measurement, and meanwhile, the reagent sealed in advance is calibrated through a special calibration process, and the complicated operation of reagent calibration is not needed when the testing reagent is used, so that the detection process of the biochemical detector with the incubation groove 205 assembly is instant and simple. Wherein, because the test reagent is the disposable single reagent that uses of sealing up, consequently can effectively avoid the problem of the expiration date of opening the bottle, not lead to the measuring accuracy to reduce when using again because of reagent remains.
In addition, when the sample is detected and analyzed by using the incubator assembly of the biochemical analyzer in this embodiment, the chip cartridge 204 is put in from the inlet of the chip cartridge 204 in the linear channel, the chip cartridge 204 is driven to pass through the linear channel by the driving mechanism 203, the puncture of the sealing film of the chip cartridge 204 by the puncture site 2052 is received, the sample is loaded to the punctured chip cartridge 204 by the sample loading site 2051, and the biochemical reaction value of the reactant mixed with the sample and the reagent is analyzed by the detection sites (2054, 2055), so that the sample can be tested efficiently and simply in real time.
In addition, compared with the prior art in which a reagent bottle and a reaction cup are placed in an annular incubation groove, and a biochemical analyzer for detecting a plurality of samples is provided with a plurality of human reagents in the reagent bottle, the biochemical analyzer of the incubation groove assembly provided by the embodiment has the advantages of instant simplicity in detection process, relatively high detection accuracy and the like.
In particular, the incubation slot 205 may be provided as a strip configuration. The incubation groove 205 of rectangular structure does benefit to and sets up the straight line passageway, is favorable to setting up puncture position 2052, application of sample position 2051 and detecting position (2054, 2055) along the straight line passageway for other mechanisms of biochemical analyzer can set up along the incubation groove 205 of rectangular structure, thereby reach the mechanism's position of concentrating and in order to reduce biochemical analyzer complete machine volume effect.
It should be noted that biochemical detection is a specific detection method, that is, a method of irradiating a sample through a side wall of a chip case with light to perform detection. Therefore, the portion of the sidewall of the chip cartridge 204 opposite the detection sites (2054, 2055) needs to be light permeable so that light can penetrate to illuminate the sample to be detected. As the side surface of the incubation groove 205 is provided with the detection positions (2054, 2055) communicated with the linear channel, a light path can be established, and the biochemical analysis of the sample can be realized. Meanwhile, the light path emits light to irradiate the side wall of the chip box 204, the light irradiates the sample through the light-permeable side wall, and then the light is detected through transmittance turbidimetry and/or scattering turbidimetry, so that the sample detection result is obtained.
The incubator 205 has a function of keeping the reactant at a constant temperature and providing an appropriate reaction temperature, and may be specifically composed of a heat generating device, a temperature sensor, a temperature adjusting device, and the like.
Based on the disclosure of the embodiment in fig. 1, fig. 2 is a schematic structural diagram of an incubator assembly of a biochemical analyzer according to a modified embodiment, which shows a holding and limiting mechanism of the incubator assembly of the biochemical analyzer.
Referring to fig. 1-2, the driving mechanism 203 drives the chip box 204 to pass by driving the clamping and limiting mechanism to move. Specifically, the clamping and limiting mechanism comprises a limiting block 2020 and front and rear sliders (2021, 2023) connected through a spring; the limiting block 2020 limits the chip cartridge 204; one side of the front and back sliders (2021, 2023) is provided with a rotary hook capable of rotatably clamping the chip box 204, and the other side is connected with the driving mechanism 203.
In this embodiment, the driving mechanism 203 drives the chip box 204 to pass by driving the clamping and limiting mechanism, so that the chip box 204 can be clamped for bidirectional transportation and can be accurately positioned at a required position. The front and rear sliders (2021, 2023) are connected through springs, and a rotating hook capable of rotatably clamping the chip box 204 is arranged on one side of the front and rear sliders (2021, 2023), so that the front and rear sliders (2021, 2023) can be driven to move by the spring force, and the rotating hook on the front and rear sliders (2021, 2023) is driven to rotate to clamp the chip box 204 without a gap, thereby improving the positioning accuracy of the chip box 204. In addition, the driving mechanism 203 can select a linear driving mechanism 203 such as a conveyor belt module and a screw motor module, so as to achieve the purpose of driving the chip box 204 to pass back and forth along a linear channel.
Based on the disclosure of the embodiment in fig. 1 or fig. 2, fig. 3 is a schematic structural diagram of an incubation tank assembly of a biochemical analyzer provided in a modified embodiment, and shows a station layout structure of the biochemical analyzer.
Referring to FIGS. 1 to 3, the one side of the incubation slot 205 is further provided with an in-place sensor for sensing positional information of the chip cartridge 204, and the in-place sensor may be disposed near an entrance of the chip cartridge 204 in the linear channel. One side of the incubation groove 205 is also provided with a chip cartridge identification site, and the chip cartridge identification site 2053 is in communication with the linear channel. Wherein, the in-place sensor and the cartridge identification site 2053 may be disposed on the same side of the incubation well 205 as the puncturing site 2052 and the loading site 2051, or may be disposed on different sides of the incubation well 205 as the puncturing site 2052 and the loading site 2051.
The cartridge identification site 2053 may be located further from the inlet of the cartridge 204 of the linear channel than the puncturing site 2052 is located from the inlet of the cartridge 204 of the linear channel, or may be located closer to the inlet of the cartridge 204 of the linear channel than the puncturing site 2052 is located. The distance between the puncturing site 2052 and the inlet of the chip cartridge 204 of the linear channel may be longer than the distance between the loading site 2051 and the inlet of the chip cartridge 204 of the linear channel, or may be shorter than the distance between the loading site 2051 and the inlet of the chip cartridge 204 of the linear channel. Between the cartridge identification bit 2053 and the puncturing bit 2052, detection bits (2054, 2055) may be provided, the detection bits (2054, 2055) including a transmission detection bit 2054 and/or a scattering detection bit 2055, the transmission detection bit 2054 and/or the scattering detection bit 2055 may be provided side by side.
In a preferred embodiment, the position sensor, sample loading site 2051, puncturing site 2052, detection sites (2054, 2055), and cartridge identification site 2053 are located further from the inlet of the cartridge 204 in the linear channel, with reference to the inlet of the cartridge 204 in the linear channel.
It should be noted that the positioning sensor near the entrance of the chip box 204 in the linear channel can detect whether the chip box 204 is positioned at the first time, so as to trigger the further process. A transmission detection position 2054 and/or a scattering detection position 2055 are/is arranged between the cartridge identification position 2053 and the puncture position 2052, so that a light path can be established, and biochemical analysis of a sample can be realized. The cassette identification site 2053 is disposed on one side of the incubation slot 205 for identifying identification information (e.g., two-dimensional code) of the cassette 204 and confirming identity information of the cassette 204, thereby preventing errors of the test object.
Corresponding to the disclosure of the embodiment in fig. 1, fig. 4 is a process flow diagram of a biochemical analyzer method according to an embodiment, showing a process flow of the biochemical analyzer method.
Referring to fig. 1 and 4, the present embodiment provides a biochemical analysis method including:
s0, setting puncture position 2052 and sample adding position 2051 communicated with the linear channel at intervals along the direction of the linear channel on the incubation groove 205 with the linear channel inside;
s1, arranging detection positions (2054, 2055) communicated with the linear channel on the side surface of the incubation groove 205 for biochemical detection;
s2, a driving mechanism 203 is arranged at one side of the linear channel for driving the chip box 204 with the disposable test reagent sealed inside to pass through.
In this embodiment, the puncturing positions 2052 and the sample adding positions 2051 communicated with the linear channel are arranged on the incubation groove 205 with the linear channel at intervals along the direction of the linear channel, the detection positions (2054, 2055) communicated with the linear channel are arranged on the side surface of the incubation groove 205, and the driving mechanism 203 capable of driving the chip box 204 internally sealed with the disposable test reagent to pass is arranged on one side of the linear channel, so that the problems of the effective period of bottle opening and the operation of the 'calibration' process are effectively avoided, and the whole biochemical detector with the incubation groove assembly is small in size, the detection process is instant and simple, and the detection precision is improved.
It should be noted that, because the testing reagent sealed in the chip box 204 is a disposable reagent for a single person, the testing reagent is sealed in the chip box 204 in advance through the sealing film for disposable measurement, and meanwhile, the reagent sealed in advance is calibrated through a special calibration process, and the complicated operation of reagent calibration is not needed when the testing reagent is used, so that the detection process of the biochemical detector with the incubation groove assembly is instant and simple. Wherein, because the test reagent is the disposable single reagent that uses of sealing up, consequently can effectively avoid the problem of the expiration date of opening the bottle, not lead to the measuring accuracy to reduce when using again because of reagent remains.
In addition, when the sample is detected and analyzed by using the incubator assembly of the biochemical analyzer in this embodiment, the chip cartridge 204 is put in from the inlet of the chip cartridge 204 in the linear channel, the chip cartridge 204 is driven to pass through the linear channel by the driving mechanism 203, the puncture of the sealing film of the chip cartridge 204 by the puncture site 2052 is received, the sample is loaded to the punctured chip cartridge 204 by the sample loading site 2051, and the biochemical reaction value of the reactant mixed with the sample and the reagent is analyzed by the detection sites (2054, 2055), so that the sample can be tested efficiently and simply in real time.
In addition, compared with the prior art in which a reagent bottle and a reaction cup are placed in an annular incubation groove, and a biochemical analyzer for detecting a plurality of samples is provided with a plurality of human reagents in the reagent bottle, the biochemical analyzer of the incubation groove assembly provided by the embodiment has the advantages of instant simplicity in detection process, relatively high detection accuracy and the like.
In particular, the incubation slot 205 may be provided as a strip configuration. The incubation groove 205 of rectangular structure does benefit to and sets up the straight line passageway, is favorable to setting up puncture position 2052, application of sample position 2051 and detecting position (2054, 2055) along the straight line passageway for other mechanisms of biochemical analyzer can set up along the incubation groove 205 of rectangular structure, thereby reach the mechanism's position of concentrating and in order to reduce biochemical analyzer complete machine volume effect.
It should be noted that, because the side surface of the incubation groove 205 is provided with the detection positions (2054, 2055) communicated with the linear channel, a light path can be established to realize the biochemical analysis of the sample. Meanwhile, the light path emits light to irradiate the side wall of the chip box 204, the light irradiates the sample through the light-permeable side wall, and then the light is detected through transmittance turbidimetry and/or scattering turbidimetry, so that the sample detection result is obtained.
The incubator 205 has a function of keeping the reactant at a constant temperature and providing an appropriate reaction temperature, and may be specifically composed of a heat generating device, a temperature sensor, a temperature adjusting device, and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims (10)

1. An incubator assembly for a biochemical analyzer, comprising: an incubation tank with a linear channel inside; a puncture position and a sample adding position which are communicated with the linear channel are arranged on the incubation groove at intervals along the direction of the linear channel; the side surface of the incubation groove is provided with a detection position communicated with the linear channel for biochemical detection; and one side of the linear channel is provided with a driving mechanism capable of driving the chip box internally sealed with the disposable test reagent to pass.
2. The incubator assembly of the biochemical analyzer according to claim 1, wherein the driving mechanism drives the cartridge to pass by driving a clamp stopper mechanism.
3. The incubation well assembly of biochemical analyzer according to claim 2, wherein the clamping and limiting mechanism comprises a limiting block and a front and a rear slide blocks connected by a spring; the limiting block limits the chip box; one side of the front and rear sliding blocks is provided with a rotary hook capable of rotatably clamping the chip box, and one side of the front and rear sliding blocks is connected with the driving mechanism.
4. The incubator assembly for a biochemical analyzer according to claim 1, wherein the incubator is in a strip configuration.
5. The incubator assembly for a biochemical analyzer according to claim 1, wherein one side of the incubator is further provided with an in-place sensor for sensing positional information of the chip cartridge.
6. The incubator assembly of the biochemical analyzer according to claim 5, wherein the in-place sensor is disposed near an entrance of the chip cartridge of the linear channel.
7. The incubator assembly of the biochemical analyzer of claim 1, wherein the lancing site is located further from the cassette inlet of the linear channel than the loading site is located from the cassette inlet of the linear channel.
8. The incubator assembly for a biochemical analyzer according to claim 7, wherein the incubator further has a cassette recognition site provided on one side thereof; the chip box identification position is communicated with the linear channel, and the distance between the chip box identification position and the linear channel is longer than the distance between the puncture position and the chip box inlet of the linear channel.
9. The incubator assembly of the biochemical analyzer according to claim 8, wherein the detection site is disposed between the cartridge identification site and the puncture site, and comprises a transmission detection site and/or a scattering detection site.
10. A biochemical analysis method, comprising:
a puncture position and a sample adding position which are communicated with the linear channel are arranged on the incubation groove with the linear channel at intervals along the direction of the linear channel;
arranging a detection position communicated with the linear channel on the side surface of the incubation groove for biochemical detection;
and a driving mechanism capable of driving the chip box internally sealed with the disposable test reagent to pass is arranged on one side of the linear channel.
CN201910215646.4A 2019-03-21 2019-03-21 Incubation groove component of biochemical analyzer and biochemical analysis method Pending CN111721953A (en)

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CN201910215646.4A CN111721953A (en) 2019-03-21 2019-03-21 Incubation groove component of biochemical analyzer and biochemical analysis method

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Application Number Priority Date Filing Date Title
CN201910215646.4A CN111721953A (en) 2019-03-21 2019-03-21 Incubation groove component of biochemical analyzer and biochemical analysis method

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CN111721953A true CN111721953A (en) 2020-09-29

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