CN111568793B

CN111568793B - Acne removing gel and preparation method thereof

Info

Publication number: CN111568793B
Application number: CN202010312554.0A
Authority: CN
Inventors: 张小燕; 邱瑞林
Original assignee: Shanghai Jiuyi Biotechnology Co ltd
Current assignee: Shanghai Jiuyi Biotechnology Co ltd
Priority date: 2020-04-20
Filing date: 2020-04-20
Publication date: 2023-04-07
Anticipated expiration: 2040-04-20
Also published as: CN111568793A

Abstract

The invention provides an acne-removing gel and a preparation method thereof, belonging to the field of cosmetics. The acne-removing gel is prepared by dissolving salicylic acid in propylene glycol and adding poloxamer 407; the mass ratio of the propylene glycol to the poloxamer 407 is 1:1-2. The invention also discloses a preparation method of the acne-removing gel. The salicylic acid is dissolved by the propylene glycol, so that the irritation of the product to skin and pox is reduced, and the utilization rate of an effect substance is improved.

Description

Acne removing gel and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to an acne-removing gel and a preparation method thereof.

Background

Salicylic acid is a fat-soluble organic acid, and can dissolve the constituent substances between horny layers to cause the horny layer to fall off, so that the horny layer accumulated too thickly can be removed to promote metabolism. The salicylic acid acts on hair follicle wall cells, can help to remove blocked hair follicles, correct abnormal cell shedding, and has an auxiliary effect on pox caused by pore obstruction. Salicylic acid is therefore commonly used in anti-acne products. Salicylic acid is only slightly soluble in water and easily soluble in ethanol, diethyl ether, chloroform, etc., so many products are often added with alcohol as a solvent for salicylic acid. However, a large part of the acne skin belongs to sensitive skin, and the addition of acne causes the destruction of the cuticle, so that adverse reactions such as pain, wound healing inhibition and the like are easily caused after the acne skin contacts alcohol. In addition, the alcohol acne removing product causes the dissolved salicylic acid to precipitate and become a solid crystal state again along with the volatilization of alcohol, thereby influencing the skin absorption and reducing the utilization rate of the efficacy materials. Ethanol toxicology data-rabbit eye: 500mg, heavy stimulation; rabbit percutaneous open stimulation test: 15mg/24 h, moderate stimulation.

Disclosure of Invention

The first purpose of the invention is to provide an acne removing gel.

The second purpose of the invention is to provide a preparation method of the acne removing gel.

In order to achieve the purpose, the acne removing gel provided by the invention is prepared by dissolving salicylic acid in propylene glycol and then adding poloxamer 407; wherein the mass ratio of the propylene glycol to the poloxamer 407 is 1:1-2.

The invention also provides a preparation method of the acne removing gel, which comprises the following specific steps:

s1, dissolving 10g of poloxamer 407 in 50-100g of deionized water at room temperature, standing and refrigerating;

s2, adding 1g of salicylic acid into 5-10g of propylene glycol, and heating to 45-55 ℃ for dissolution;

and S3, taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform to obtain the poloxamer.

Wherein the mass ratio of the poloxamer 407 to the deionized water in the step S1 is 1:5-10.

Wherein the refrigerating temperature in the step S1 is 5 ℃.

Wherein the refrigerating time in the step S1 is 8-12h.

Wherein the mass ratio of the salicylic acid to the propylene glycol in the step S2 is 1:5-10.

Propylene glycol belongs to a low-irritation and low-toxicity solvent, and rats are injected intravenously and intraperitoneally with LD ₅₀ 7000-8000mg/kg, oral LD ₅₀ It was 2800mg/kg. Poloxamer 407 is used as a stabilizer for salicylic acid, which forms micelles in water, increasing the surface solubility of salicylic acid; poloxamer 407 has good compatibility with skin, can be used as an absorption enhancer, and can increase the absorption and utilization of salicylic acid by skin; poloxamer 407 as a high molecular material for preparing the temperature-sensitive in-situ gel has the advantages of good spreadability, large mucous membrane coverage, long detention time, simple preparation, convenient use and the like.

The invention has the beneficial effects that:

according to the invention, the propylene glycol is used as a solvent, so that the stimulation of the use of alcohol to the skin in the traditional process is reduced, and the propylene glycol and the poloxamer 407 in a specific proportion can effectively improve the acne removing effect of the acne removing gel. The invention has simple process, good product effect and better use value.

Detailed Description

In order to more clearly and completely describe the technical scheme of the invention, the invention is further described in detail by the specific embodiments, and it should be understood that the specific embodiments described herein are only used for explaining the invention, and are not used for limiting the invention, and various changes can be made within the scope defined by the claims of the invention.

Example 1

Adding 10g of poloxamer 407 into 100g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 8h; 1g of salicylic acid is added to 10g of propylene glycol; heating to 45 ℃ to dissolve; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.

Example 2

Adding 10g of poloxamer 407 into 50g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 10 hours; 1g of salicylic acid was added to 7.5g of propylene glycol; heating to 50 ℃ to dissolve; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.

Example 3

Adding 10g of poloxamer 407 into 50-100g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 12 hours; 1g of salicylic acid is added to 5g of propylene glycol; heating to 55 ℃ for dissolution; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.

Comparative example 1

Adding 10g of poloxamer 407 into 100g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 8h; adding 1g of salicylic acid to 15g of propylene glycol; heating to 45 ℃ to dissolve; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.

Comparative example 2

Adding 5g of poloxamer 407 into 100g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 8h; 1g of salicylic acid is added to 10g of propylene glycol; heating to 45 ℃ to dissolve; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.

Performance evaluation:

100 acne patients were selected for the trial, with male and female halves, ages 20-30 years, and a mean age of 24 years. The average was divided into 5 groups (half of men and women), and the acne removing gels prepared in examples and comparative examples were used for experience. The composition is administered once a day for 2 weeks, and then the therapeutic effect is evaluated. The evaluation was divided into: 1. and (3) curing: the skin loss is reduced by more than 90 percent, and no new rash symptoms appear; 2. the effect is shown: the skin loss is reduced by more than 60 percent, and the symptoms are obviously relieved; 3. the method has the following advantages: the skin loss is reduced by more than 30 percent, and the symptoms are improved; 4. and (4) invalidation: the skin loss resolved below 30% with no significant change in symptoms. The evaluation results are shown in table 1.

TABLE 1

Examples	Cure of disease	Show effect	Is effective	Invalidation	Total effective rate
						Example 1	1	12	6	1	95％
Example 2	3	13	4	0	100％
						Example 3	2	10	6	2	90％
Comparative example 1	0	3	12	5	75％
						Comparative example 2	0	4	10	6	70％

The performance evaluation effect of the table 1 shows that the acne removing gel provided by the invention has a good acne removing effect, and the effect of the comparative example shows that when the ratio of the propylene glycol to the poloxamer 407 exceeds 1:1-2, the acne removing effect is poor, and no curing effect is achieved.

Finally, it should be emphasized that the above-described preferred embodiments of the present invention are merely examples of implementations, and it should be understood that various changes and modifications may be made by those skilled in the art, and any changes, equivalents, improvements and the like, which fall within the spirit and principle of the present invention, should be included in the scope of the present invention.

Claims

1. The acne removing gel is characterized in that the preparation method of the acne removing gel comprises the following steps: adding 10g of poloxamer 407 into 50g of deionized water at room temperature, standing in a refrigerating chamber at 5 ℃ for 10 hours; 1g of salicylic acid was added to 7.5g of propylene glycol; heating to 50 ℃ to dissolve; and taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform.