CN1115638A - External-use drug form - Google Patents
External-use drug form Download PDFInfo
- Publication number
- CN1115638A CN1115638A CN 94110715 CN94110715A CN1115638A CN 1115638 A CN1115638 A CN 1115638A CN 94110715 CN94110715 CN 94110715 CN 94110715 A CN94110715 A CN 94110715A CN 1115638 A CN1115638 A CN 1115638A
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- China
- Prior art keywords
- phase transformation
- external
- substrate
- medicament
- medicine
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Abstract
The present invention aims at increasing the effect of drug by means of strengthening the absorption of body tissues to drug and making drug prepn and storage easy. The present invention uses paraffin wax and other phase-change matter as matrix, which is mixed with drug to prepare phase-change drug prepn. Through the combined physiotherapeutic and pharmacotherapeutic effects, twice curative effect may be obtained.
Description
A kind of dosage form of the relevant medical medicine for external use of the present invention.
The dosage form of medicine for external use has water preparation, unguentum, tincture, powder, oil preparation etc. at present, and the substrate of used medicine is water, ethanol, vaseline, vegetable oil, glycerol, starch etc., and there is following problem in the medicine for external use of these dosage forms:
1. the common feature of the medicine for external use of above-mentioned dosage form is the restriction of depositing Shi Shouqi encapsulation, and after encapsulation was opened, drug effect was persistence and scatters and disappears and weaken.
2. skin is limited to the absorbability of above-mentioned dosage form external used medicine under general state, makes the drug effect performance be subjected to certain restriction.
3. some Chinese herbal medicine for external use preparations are difficult to deposit the popularization and application that has limited it because of its water decoction.
The purpose of this invention is to provide a kind of medicine for external use novel form that can remedy above-mentioned external-use drug form weak point, strengthen the absorbability of skin by the physical therapy effect to medicine, reach the purpose that physical therapy and medication organically combine, for inner disease outer treat is opened up a kind of dynamical Therapeutic Method.
The present invention is achieved in that topical agent is made up of medicine and substrate, it is characterized in that used substrate is to have the phase transformation substrate that the material of phase-change characteristic constitutes, and makes the phase transformation medicament with medicine with phase transformation substrate.Can make the fusing of phase transformation medicament by heating, discharge contained drug effect and bring into play the therapeutical effect of medicine, simultaneously, phase transformation substrate can produce persistent warm-heat effect, makes the skin histology telangiectasis, body of gland is open, local sweating promotes and has strengthened the absorbability of skin to medicine, and local organization blood circulation under warm-heat effect is accelerated, thereby promoted the performance of the efficacy of a drug, made phase transformation substrate and medicine produce collaborative mutually therapeutic effect.Drug effect is closed closely, makes the phase transformation medicament when non-working condition, be easy to deposit and preserve drug effect.
The selected phase transformation substrate of the present invention is the organic high molecular compound nontoxic, harmless, non-stimulated to human body, and as wax class, esters, polymerization alcohols, TPO and composition thereof, its melting range is 40-70 ℃, and best melting range is 50-6 ℃.Fusing point is lower than 40 ℃ phase transformation substrate easy fusing in summer and difficult the preservation, and heat effect is poor, and therapeutic effect is also poor; Fusing point is higher than 70 ℃, then surpasses the treatment temperature of human body tolerance and can't use.Can add inorganic substances in the phase transformation substrate of the present invention, as white carbon, active hargil etc. to improve the mechanical and physical performance of phase transformation substrate.
The used medicine of the present invention is chemical drugs, Chinese herbal medicine and various biological preparation etc., according to the characteristic and the needs of used medicine in the specific prescription, pharmaceutical preparation directly added in the phase transformation substrate mix or take effective ingredient and make the phase transformation medicament with upright the connecing of phase transformation base.
Phase transformation medicament of the present invention can be taked following manner to execute to control:
1. adopt flexible material absorption or adhere to the phase transformation medicament, make the phase transformation tablet, heating makes its fusing and spreads on affected part constant temperature treatment to the phase transformation tablet to adopt constant temperature heating device during use.Flexible material can be selected fabric, adhesive-bonded fabric, paper, sponge etc. for use.
2. the phase transformation medicament is filled in the soft sealing bag, make the phase transformation medicated bag, the material that its soft sealing bag selects for use the phase transformation medicament that can make fusing quantitatively to appear the bag surface is made, as rubber, rubber and plastic and composite etc., pattern of fever or outer pattern of fever in this medicated bag can be made into, make the fusing of phase transformation medicament and quantitatively ooze out the medicated bag surface by inside heating or external heat during use, spread on the affected part treatment.
The present invention adopts phase change material to have the following advantages and effect as drug matrices.
1. naturopathy and Drug therapy are organically combined, under the persistent warm-heat effect of phase transformation substrate, skin histology blood capillary and sweat gland expansion, blood circulation is accelerated, thereby skin histology is strengthened the absorbability of medicine, and the efficacy of a drug is effectively brought into play, and resonable curative effect should be worked in coordination with down with the mutual of medication effect, can obtain the curative effect of getting twice the result with half the effort, this phase transformation medicament is that inner disease outer treat has been opened up a kind of new dynamical Therapeutic Method.
2. phase transformation substrate has good closed performance, can preserve drug effect effectively when curdled appearance, then can bring into play drug effect effectively by heat fused during use, has the advantages that to be easy to deposit.
3. preparation such as Chinese herbal medicine can be directly fried in phase transformation substrate, so this phase transformation medicament provides a kind of simple and practical method for the preparation and the storage of Chinese herbal medicine for external use.
Be specific embodiments of the invention below:
Select 54-58 ℃ medical pure wax and specific medicine prescription for use, with White paraffin water proof heat fused, the medicine that need are fried is put into wax, continue fried with 70 ℃ wax temperature, the time fried according to needing to be grasped of the property of medicine, filter then, put into other ground medicated powder mix homogeneously again, be prepared into phase transformation medicine wax.
1. the making of phase transformation tablet and use:
Select 40-80g/M for use
2Non-woven fabrics, immerse in the medicine wax of fusing, make tablet through mangle-cooling-operations such as section.During use the phase transformation tablet being spread on the affected part continues heating with 58-60 ℃ thermostatic heater to tablet and executes and control.
2. the making of phase transformation medicated bag and use:
Select for use self to possess heater, and the compounded rubber bag that the medicine wax of fusing is quantitatively oozed out, will pour in the bag after the fusing of medicine wax, the phase transformation medicated bag is made in encapsulation, controls by executing after the fusing of medicated bag self heating messenger drug wax.
Claims (5)
1. external-use drug form, form by medicine and substrate, it is characterized in that used substrate is the phase transformation substrate with material formation of phase-change characteristic, medicine is made external phase transformation medicament with phase transformation substrate, phase transformation substrate is solid under the room temperature, drug effect can be sealed, then drug effect can be discharged when being heated to molten state.
2. external-use drug form according to claim 1 is characterized in that phase transformation substrate is organic high molecular compound, and as wax class, esters, polymerization alcohols, TPO and composition thereof, melting range is 40-70 ℃, and best melting range is 50-60 ℃.
3. according to claim 1 and the described external-use drug form of claim 2, it is characterized in that to add inorganic substances in the said phase transformation substrate, as white carbon, active hargil etc., to improve the mechanical and physical property of phase transformation substrate.
4. external-use drug form according to claim 1 is characterized in that said phase transformation medicament can or adhere to flexible material absorption, as fabric, adhesive-bonded fabric, paper, sponge material etc., makes external phase transformation tablet, controls by tablet is heated to execute.
5. external-use drug form according to claim 1, it is characterized in that said phase transformation medicament can be filled in the soft sealing bag that the phase transformation medicament that can make fusing quantitatively appears, as rubber bag etc., make the phase transformation medicated bag, control by the fusing of phase transformation medicament being executed medicated bag inside or external heat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110715 CN1115638A (en) | 1994-07-25 | 1994-07-25 | External-use drug form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94110715 CN1115638A (en) | 1994-07-25 | 1994-07-25 | External-use drug form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1115638A true CN1115638A (en) | 1996-01-31 |
Family
ID=5034652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 94110715 Pending CN1115638A (en) | 1994-07-25 | 1994-07-25 | External-use drug form |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1115638A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100397866C (en) * | 2001-12-06 | 2008-06-25 | 佳能株式会社 | Image processor, image processing method, program and memory medium |
| WO2011079746A1 (en) * | 2009-12-30 | 2011-07-07 | 华东医学生物技术研究所 | Tube comprising fusible layer |
-
1994
- 1994-07-25 CN CN 94110715 patent/CN1115638A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100397866C (en) * | 2001-12-06 | 2008-06-25 | 佳能株式会社 | Image processor, image processing method, program and memory medium |
| WO2011079746A1 (en) * | 2009-12-30 | 2011-07-07 | 华东医学生物技术研究所 | Tube comprising fusible layer |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |