CN111551594B - Detection object concentration monitoring circuit, detection object concentration monitoring system and terminal equipment - Google Patents
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Abstract
The invention relates to the technical field of biosensors, in particular to a current type detection object concentration monitoring circuit, a current type detection object concentration monitoring system and terminal equipment. In the monitoring circuit, a biosensor signal preprocessing module is added, the module is provided with two output ends, and then the flow direction of a current signal can be controlled, wherein when the current flows to an alternating current impedance measuring module, the alternating current impedance measuring module can be used for adjusting a concentration calculation algorithm of a detected object, so that the accuracy of the concentration calculation of the detected object is ensured.
Description
Technical Field
The invention relates to the technical field of biological sensors, in particular to a detection object concentration monitoring circuit, a detection object concentration monitoring system and terminal equipment.
Background
Amperometric biosensing systems can be used to continuously monitor a given concentration of a detector in human tissue. Common amperometric biosensing systems include continuous blood glucose monitoring systems. It can monitor the change of glucose concentration in human tissue fluid by an implanted amperometric glucose sensor. The continuous and uninterrupted blood sugar monitoring can better control the blood sugar change of diabetics, has important guiding significance for life laws, activities, sports, diet and reasonable medication, and can help the patients to find problems at any time and seek medical attention in time.
The amperometric detection apparatus is used for detecting the concentration of a detection object in tissue fluid, blood or solution, and can record and transmit the concentration of the detection object with electrochemical activity by measuring the electrochemical current.
Disclosure of Invention
In view of this, the invention provides a current type detection object concentration monitoring circuit, a system and a terminal device, which realize detection object concentration monitoring, and a preprocessing module is added in the monitoring circuit, wherein the module can switch the current signal flow direction, so that the monitoring circuit has the function of adjusting the detection object concentration algorithm, and the accuracy of detection object concentration calculation is further ensured.
The invention provides a detection object concentration monitoring circuit, which comprises a current type electrochemical sensor, a current type electrochemical sensor signal preprocessing module, a detection object current acquisition and measurement module and an alternating current impedance measurement module, wherein: the input end of the current type electrochemical sensor signal preprocessing module is connected with the current type electrochemical sensor, the first output end is connected with the detection object current acquisition and measurement module, and the second output end is connected with the alternating current impedance measurement module; the current type electrochemical sensor signal preprocessing module is used for receiving a current signal sent by the current type electrochemical sensor and controlling the current signal to flow to the detector current acquisition measuring module or the alternating current impedance measuring module; the detecting object current acquisition and measurement module is used for converting the current signal into a voltage signal for calculating the concentration of the detecting object; the alternating current impedance measuring module is used for carrying out alternating current impedance detection according to the current signal, and adjusting the algorithm for calculating the concentration of the detected object according to the alternating current impedance detection result; the current-type electrochemical sensor signal preprocessing module comprises a switching circuit and a switching controller, wherein: the switching circuit comprises 4 single-pole double-throw switches; the 4 input ends of the switching circuit are respectively connected with a first working electrode, a second working electrode, a reference electrode and a counter electrode of the current-type electrochemical sensor; the 4 first output ends of the switching circuit are connected with the object current acquisition and measurement module, and the 4 second output ends are connected with the alternating current impedance measurement module; the switching controller is used for controlling the closing direction of the single-pole double-throw switch; the alternating current impedance measurement module comprises an alternating current excitation source and a signal receiving and processing module; the alternating current excitation source comprises a phase accumulator, a sine read-only memory, a digital-to-analog converter and a programmable gain instrument amplifier which are connected in series, wherein the output end of the alternating current excitation source is connected with one second output end of the 4 single-pole double-throw switches, when alternating current impedance is measured, the phase accumulator generates a voltage signal value of an alternating current sine wave and stores the voltage signal value in the sine read-only memory, the analog-to-digital converter reads the value and then outputs a sine wave signal to one electrode of the current type electrochemical sensor through the programmable gain instrument amplifier; the signal receiving and processing module comprises a current-voltage conversion circuit, a programmable gain instrument amplifier, an anti-mixing filter, an analog-to-digital converter and a discrete Fourier transform circuit which are connected in series, wherein the input end of the current-voltage conversion circuit is connected with one of the other 3 second output ends of the 4 single-pole double-throw switches, and an alternating current excitation signal returns to the signal receiving and processing module through the other electrode of the current-type electrochemical sensor after passing through subcutaneous tissue fluid of a human body.
Optionally, electrostatic discharge circuits are respectively arranged between the 4 input ends of the switching circuit and the first working electrode, the second working electrode, the reference electrode and the counter electrode of the current-type electrochemical sensor.
Optionally, the detecting object current collecting and measuring module comprises an I/V converting circuit, a dynamic feedback loop and a biasing circuit; the I/V conversion circuit comprises a first operational amplifier circuit and a second operational amplifier circuit, the first operational amplifier circuit is connected with a first resistor in parallel, the second operational amplifier circuit is connected with a second resistor in parallel, the reverse input end of the first operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the first working electrode, the output end of the first operational amplifier circuit is connected with the first voltage output end, the reverse input end of the second operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the second working electrode, and the output end of the second operational amplifier circuit is connected with the second voltage output end; the dynamic feedback loop comprises a third operational amplifier circuit, the reverse input end of the third operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the reference electrode, the output end of the third operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the counter electrode, and the output end of the third operational amplifier circuit is also connected with a third voltage output end; the input end of the bias circuit is connected with the homodromous input end of the third operational amplifier circuit, and the output end of the bias circuit is connected with the fourth voltage output end.
Optionally, low-pass filters are respectively arranged between the first voltage output end and the output end of the first operational amplifier circuit, between the second voltage output end and the output end of the second operational amplifier circuit, between the third voltage output end and the output end of the third operational amplifier circuit, and between the fourth voltage output end and the output end of the biasing circuit.
The invention also provides a detection object concentration monitoring system which comprises the detection object concentration monitoring circuit, a microcontroller, a memory and a communication module; the detection object current acquisition and measurement module and the alternating current impedance measurement module of the detection object concentration monitoring circuit are connected with the microcontroller, and the memory and the communication module are respectively connected with the microcontroller; the microcontroller is used for executing an algorithm for calculating the concentration of the detected object or executing an algorithm for calculating the concentration of the detected object after the alternating current impedance measurement module is adjusted.
Optionally, the memory is at least one of: program memory, data memory or static random access memory.
Optionally, the communication module is an NFC communication module or a bluetooth wireless communication module.
The invention also provides a terminal device comprising the detection object concentration monitoring system.
Drawings
For purposes of illustration and not limitation, the invention will now be described in accordance with its preferred embodiments, particularly with reference to the accompanying drawings, in which:
FIG. 1 is a schematic diagram of a detector concentration monitoring circuit provided in accordance with an embodiment of the present invention;
FIG. 2 is a schematic diagram of a sensed current collection measurement module in a sensed concentration monitoring circuit;
FIG. 3 is a schematic diagram of an AC impedance measurement module in a analyte concentration monitoring circuit;
fig. 4 is a schematic diagram of a detector concentration monitoring system provided according to an embodiment of the present invention.
Detailed Description
In the embodiment of the invention, a current type electrochemical sensor signal preprocessing module is added in the monitoring circuit, the module is provided with two output ends, and the flow direction of a current signal can be controlled, wherein when the current flows to an alternating current impedance measuring module, an alternating current impedance measuring module can be used for adjusting a detection object concentration algorithm, so that the accuracy of detection object concentration calculation is ensured, and the detection object concentration calculation is described in detail below.
Fig. 1 is a schematic diagram of a detection object concentration monitoring circuit provided according to an embodiment of the present invention. As shown in fig. 1, the amperometric electrochemical sensor includes 4 electrodes, the electrode W1 and the electrode W2 are a first working electrode and a second working electrode, respectively, for outputting a current signal, the electrode RE is a reference electrode for providing a stable reference voltage for the amperometric electrochemical sensor, and the electrode CE is a counter electrode for providing electrons required for an electrochemical reaction for the working electrodes. The current-type electrochemical sensor sends a current signal (analog signal) to the current-type electrochemical sensor signal preprocessing module.
The current type electrochemical sensor signal preprocessing module receives a current signal sent by the current type electrochemical sensor and controls the flow direction of the current signal through the switching circuit. As shown in fig. 1, the signal preprocessing module of the current-mode electrochemical sensor comprises a switching circuit and a switching controller, wherein the switching circuit comprises 4 single-pole double-throw switches which are respectively connected with 4 working electrodes of the current-mode electrochemical sensor, the switching controller can control the closing direction of the single-pole double-throw switches, namely, two closing directions can be realized through the single-pole double-throw switches, one direction is to control the single-pole double-throw switches to be connected with a first output end, a current signal flows to a detection object current acquisition and measurement module when the single-pole double-throw switches are in the closing direction, the other direction is to control the single-pole double-throw switches to be connected with a second output end, and the current signal flows to an alternating current impedance measurement module when the single-pole double-throw switches are in the closing direction. When the monitoring circuit is used, the switching controller controls the single-pole double-throw switch to be in a normal state of communication with the first output end, and a long-time current keeping signal is sent to the detection object current acquisition and measurement module. The single-pole double-throw switch is only periodically switched to the alternating-current impedance measuring module, and the alternating-current impedance is required to be measured within a limited time (such as 200ms or other time which can be set by a user) after the switching is finished, and the single-pole double-throw switch is switched back to the detecting object current collecting and measuring module after the measuring is finished.
As shown in fig. 1, electrostatic discharge circuits ESD are respectively arranged between the 4 input ends of the switching circuit and the 4 electrodes of the amperometric electrochemical sensor, namely, the first working electrode, the second working electrode, the reference electrode and the counter electrode. The electrostatic discharge circuit ESD can discharge static electricity transferred by a human body, and damage of the static electricity to electronic elements in the signal preprocessing module of the current-type electrochemical sensor is avoided.
Fig. 2 is a schematic diagram of a specimen current collection measurement module in a specimen concentration monitoring circuit. The alternating current impedance measurement module comprises an I/V conversion circuit, a dynamic feedback loop and a bias circuit. As shown in fig. 2, the I/V conversion circuit includes a first operational amplifier circuit AMP1 and a second operational amplifier circuit AMP2. The first operational amplifier circuit AMP1 is connected in parallel with the first resistor R2, the inverting input terminal NEG of the first operational amplifier circuit AMP1 is connected to the first output terminal of the single-pole double-throw switch connected to the first working electrode W1, and the output terminal OUT of the first operational amplifier circuit AMP1 is connected to the first voltage output terminal W1F. The second operational amplifier circuit AMP2 is connected in parallel with the second resistor R1, the inverting input terminal NEG of the second operational amplifier circuit AMP2 is connected to the first output terminal of the single-pole double-throw switch connected to the second working electrode W2, and the output terminal OUT of the second operational amplifier circuit AMP2 is connected to the second voltage output terminal W2F. The dynamic feedback loop comprises a third operational amplifier circuit AMP3, a reverse input end NEG of the third operational amplifier circuit AMP3 is connected with a first output end of a single-pole double-throw switch connected with a reference electrode RE, an output end OUT of the third operational amplifier circuit AMP3 is connected with a first output end of the single-pole double-throw switch connected with a counter electrode CE, and an output end OUT of the third operational amplifier circuit AMP3 is also connected with a third voltage output end CEF. The input end of the bias circuit is connected with the homodromous input end POS of the third operational amplifier circuit AMP3, and the output end of the bias circuit is connected with the fourth voltage output end BF.
As shown in fig. 2, the detection object current collection and measurement module in the detection object concentration monitoring circuit includes two BIAS circuits, namely a BIAS circuit RE BIAS and a BIAS circuit WE1/WE2 BIAS, and the two BIAS circuits respectively provide programmable BIAS voltages for the reference electrode RE and the first working electrode W1 and the second working electrode W2. The first and second operational circuits AMP1 and AMP2 are used to convert current signals on the first and second working electrodes W1 and W2 into voltage signals. The third operational amplifier circuit AMP3 is a dynamic feedback loop, providing a stable reference voltage point for the amperometric electrochemical sensor, and providing a stable current source for the first working electrode W1 and the second working electrode W2. The resistors R1 and R2 in the I/V conversion circuit are used for configuring I/V conversion amplification factors of the first operational amplifier circuit AMP1 and the second operational amplifier circuit AMP2, and the resistor Rf and the capacitor Cf form a passive first-order low-pass filter for filtering out inherent noise of the current-type electrochemical sensor.
Fig. 3 is a schematic diagram of an ac impedance measurement module in a analyte concentration monitoring circuit. As shown in fig. 3, the ac impedance measurement module includes an ac excitation source and a signal receiving processing module. The alternating current excitation source comprises a phase accumulator PhaseAccumulator, a sine read-only memory (SIN ROM), a digital-to-analog converter (DAC) and a programmable gain instrumentation amplifier (PGA) which are connected in series, and the output end of the alternating current excitation source is connected with one second output end of the 4 single-pole double-throw switches. When the alternating current impedance is measured, a voltage signal value of an alternating current sine wave is generated by a phase accumulator and stored in a sine read-only memory (SIN ROM), an analog-to-digital converter (DAC) reads the value and then outputs a sine wave signal, and the sine wave signal is output to one electrode of the current type electrochemical sensor through a programmable gain instrumentation amplifier (PGA).
As shown in fig. 3, the signal receiving processing module includes a current-to-voltage conversion circuit CurrentTovoltage, a programmable gain instrumentation amplifier PGA, an anti-aliasing filter, an analog-to-digital converter ADC, and a discrete fourier transform circuit DFT connected in series. The input end of the current-voltage conversion circuit is connected with one of the other 3 second output ends of the 4 single-pole double-throw switches. The alternating current excitation signal is returned to the signal receiving and processing module through the other electrode of the current electrochemical sensor after passing through subcutaneous tissue fluid of a human body, the alternating current excitation signal is subjected to current-voltage conversion in the signal receiving and processing module, then is amplified by the programmable gain instrumentation amplifier PGA, enters an anti-aliasing filter, finally enters an analog-to-digital converter ADC, and the converted digital signal is subjected to discrete Fourier transformation, so that alternating current impedance comprising a real part and an imaginary part is obtained.
FIG. 4 is a schematic diagram of a analyte concentration monitoring system provided in accordance with an embodiment of the present invention; as shown in fig. 4, the system comprises the detection object concentration monitoring circuit shown in fig. 1, and also comprises a microcontroller, a memory and a communication module; the detection object current acquisition and measurement module and the alternating current impedance measurement module of the detection object concentration monitoring circuit are connected with the microcontroller, and the memory and the communication module are respectively connected with the microcontroller; the microcontroller is used for executing an algorithm for calculating the concentration of the detected object or executing an algorithm for calculating the concentration of the detected object after the alternating current impedance measurement module is adjusted.
The microcontroller used in the embodiment of the invention has ultra-low sleep power consumption, lower working current and processing capacity of Fourier transformation; the microprocessor also includes general input/output port, timer, general asynchronous transceiver, monitoring software, internal clock, debugging port, etc. The microcontroller can be externally connected with a Bluetooth chip or a Bluetooth module in the aspect of data transmission, so that the Bluetooth transmission function of detecting the concentration data of the object is realized. The microcontroller can also monitor the chip and the peripheral equipment thereof, and the working state of the current-type electrochemical sensor, and can provide alarm information if abnormality exists.
The memory is at least one of a program memory, a data memory or a static random access memory, the program memory and the data memory are nonvolatile memories, the erasing life of at least 200 times is required to be met, and the static random access memory is of a general structure. The communication module is an NFC communication module or a Bluetooth wireless communication module, wherein the NFC communication module supports radio frequency non-contact communication, and the power supply can be self-powered by NFC and can wake up the microcontroller.
The embodiment of the invention also provides a terminal device which comprises a detection object concentration monitoring system, a display screen, keys, a battery and the like, and is used for receiving the target detection object monitoring data and performing operations such as display, storage and the like.
The above embodiments do not limit the scope of the present invention. It will be apparent to those skilled in the art that various modifications, combinations, sub-combinations and alternatives can occur depending upon design requirements and other factors. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of the present invention.
Claims (8)
1. The utility model provides a detection thing concentration monitoring circuit, includes current type electrochemical sensor, its characterized in that, this circuit still includes current type electrochemical sensor signal preprocessing module, detection thing current collection measurement module and exchanges impedance measurement module, wherein:
the input end of the current type electrochemical sensor signal preprocessing module is connected with the current type electrochemical sensor, the first output end is connected with the detection object current acquisition and measurement module, and the second output end is connected with the alternating current impedance measurement module;
the current type electrochemical sensor signal preprocessing module is used for receiving a current signal sent by the current type electrochemical sensor and controlling the current signal to flow to the detector current acquisition measuring module or the alternating current impedance measuring module;
the detecting object current acquisition and measurement module is used for converting the current signal into a voltage signal for calculating the concentration of the detecting object;
the alternating current impedance measuring module is used for carrying out alternating current impedance detection according to the current signal, and adjusting the algorithm for calculating the concentration of the detected object according to the alternating current impedance detection result;
the current-type electrochemical sensor signal preprocessing module comprises a switching circuit and a switching controller, wherein:
the switching circuit comprises 4 single-pole double-throw switches;
the 4 input ends of the switching circuit are respectively connected with a first working electrode, a second working electrode, a reference electrode and a counter electrode of the current-type electrochemical sensor;
the 4 first output ends of the switching circuit are connected with the object current acquisition and measurement module, and the 4 second output ends are connected with the alternating current impedance measurement module;
the switching controller is used for controlling the closing direction of the single-pole double-throw switch;
the alternating current impedance measurement module comprises an alternating current excitation source and a signal receiving and processing module;
the alternating current excitation source comprises a phase accumulator, a sine read-only memory, a digital-to-analog converter and a programmable gain instrument amplifier which are connected in series, wherein the output end of the alternating current excitation source is connected with one second output end of the 4 single-pole double-throw switches, when alternating current impedance is measured, the phase accumulator generates a voltage signal value of an alternating current sine wave and stores the voltage signal value in the sine read-only memory, the analog-to-digital converter reads the value and then outputs a sine wave signal to one electrode of the current type electrochemical sensor through the programmable gain instrument amplifier;
the signal receiving processing module comprises a current-voltage conversion circuit, a programmable gain instrument amplifier, an anti-mixing filter, an analog-to-digital converter and a discrete Fourier transform circuit which are connected in series, wherein the input end of the current-voltage conversion circuit is connected with one of the other 3 second output ends of the 4 single-pole double-throw switches, and an alternating current excitation signal returns to the signal receiving processing module through the other electrode of the current-type electrochemical sensor.
2. The analyte concentration monitoring circuit of claim 1, wherein electrostatic discharge circuits are provided between the 4 inputs of the switching circuit and the first working electrode, the second working electrode, the reference electrode, and the counter electrode of the amperometric electrochemical sensor, respectively.
3. The analyte concentration monitoring circuit of claim 1, wherein the analyte current collection measurement module comprises an I/V conversion circuit, a dynamic feedback loop, and a bias circuit;
the I/V conversion circuit comprises a first operational amplifier circuit and a second operational amplifier circuit, the first operational amplifier circuit is connected with a first resistor in parallel, the second operational amplifier circuit is connected with a second resistor in parallel, the reverse input end of the first operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the first working electrode, the output end of the first operational amplifier circuit is connected with the first voltage output end, the reverse input end of the second operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the second working electrode, and the output end of the second operational amplifier circuit is connected with the second voltage output end;
the dynamic feedback loop comprises a third operational amplifier circuit, the reverse input end of the third operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the reference electrode, the output end of the third operational amplifier circuit is connected with the first output end of the single-pole double-throw switch connected with the counter electrode, and the output end of the third operational amplifier circuit is also connected with a third voltage output end;
the input end of the bias circuit is connected with the homodromous input end of the third operational amplifier circuit, and the output end of the bias circuit is connected with the fourth voltage output end.
4. The analyte concentration monitoring circuit of claim 3, wherein low pass filters are provided between the first voltage output and the output of the first op-amp circuit, between the second voltage output and the output of the second op-amp circuit, between the third voltage output and the output of the third op-amp circuit, and between the fourth voltage output and the output of the bias circuit, respectively.
5. A analyte concentration monitoring system comprising the analyte concentration monitoring circuit of any one of claims 1 to 4, and further comprising a microcontroller, a memory, and a communication module;
the detection object current acquisition and measurement module and the alternating current impedance measurement module of the detection object concentration monitoring circuit are connected with the microcontroller, and the memory and the communication module are respectively connected with the microcontroller;
the microcontroller is used for executing an algorithm for calculating the concentration of the detected object or executing an algorithm for calculating the concentration of the detected object after the alternating current impedance measurement module is adjusted.
6. The analyte concentration monitoring system of claim 5, wherein the memory is at least one of: program memory, data memory or static random access memory.
7. The analyte concentration monitoring system of claim 5, wherein the communication module is an NFC communication module or a bluetooth wireless communication module.
8. A terminal device comprising the analyte concentration monitoring system according to any one of claims 5 to 7.
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| CN202010468283.8A CN111551594B (en) | 2020-05-28 | 2020-05-28 | Detection object concentration monitoring circuit, detection object concentration monitoring system and terminal equipment |
| PCT/CN2021/095271 WO2021238808A1 (en) | 2020-05-28 | 2021-05-21 | Test substance concentration monitoring circuit and system, and terminal device |
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| CN202010468283.8A CN111551594B (en) | 2020-05-28 | 2020-05-28 | Detection object concentration monitoring circuit, detection object concentration monitoring system and terminal equipment |
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| CN111551594B (en) * | 2020-05-28 | 2024-01-26 | 微泰医疗器械(杭州)股份有限公司 | Detection object concentration monitoring circuit, detection object concentration monitoring system and terminal equipment |
| CN114441617A (en) * | 2022-01-13 | 2022-05-06 | 天津大学 | Ganglioside GD2 mobile detection device based on plasma modified electrode |
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