CN111053554A - Ultramicro flexible linear deep brain electrode - Google Patents
Ultramicro flexible linear deep brain electrode Download PDFInfo
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- CN111053554A CN111053554A CN201911190517.0A CN201911190517A CN111053554A CN 111053554 A CN111053554 A CN 111053554A CN 201911190517 A CN201911190517 A CN 201911190517A CN 111053554 A CN111053554 A CN 111053554A
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- 210000004556 brain Anatomy 0.000 title claims abstract description 57
- 230000000694 effects Effects 0.000 claims abstract description 21
- 210000002569 neuron Anatomy 0.000 claims abstract description 21
- 239000000956 alloy Substances 0.000 claims abstract description 8
- 230000004936 stimulating effect Effects 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims abstract description 6
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 claims abstract description 5
- 239000004642 Polyimide Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920001721 polyimide Polymers 0.000 claims abstract description 5
- 210000003710 cerebral cortex Anatomy 0.000 claims description 7
- 210000005013 brain tissue Anatomy 0.000 claims description 4
- 229910045601 alloy Inorganic materials 0.000 claims description 3
- 230000000638 stimulation Effects 0.000 abstract description 4
- 238000003491 array Methods 0.000 abstract description 2
- 239000000696 magnetic material Substances 0.000 description 4
- 230000001537 neural effect Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000003477 cochlea Anatomy 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000004126 nerve fiber Anatomy 0.000 description 2
- 230000007383 nerve stimulation Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 210000000860 cochlear nerve Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6868—Brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0541—Cochlear electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
- A61N1/36038—Cochlear stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
Abstract
The invention relates to an ultramicro flexible linear deep brain electrode which comprises an electrode for stimulating and recording brain neuron electrical activities, wherein the electrode comprises a plurality of electrode wires, the electrode wires are of wire-shaped structures made of platinum-iridium alloy materials, the diameters of the electrode wires are 12-13 mu m, the lengths of the electrode wires are different, the electrode wires are sequentially arranged in parallel according to the increasing length sequence, the tips of the electrode wires are positioned on the same straight line, and the electrode wires are used for stimulating and recording brain neuron electrical activities of different depths through the array; flexible membrane structures made of polyimide materials are coated between the electrode wires and on the outer side of the electrode wire array. The electrode provided by the invention can effectively avoid non-specific damage, and has the characteristics of strong biocompatibility and capability of measuring the electrical activity of brain neurons at different depths according to requirements. The electrode array can be used for brain computer interface and deep brain stimulation, and can also be used for cochlear stimulation electrode arrays of artificial auditory sense.
Description
Technical Field
The invention relates to the technical field of brain electrodes, in particular to an ultramicro flexible linear deep brain electrode.
Background
The brain electrode array is used for the collection of intracerebral signals of brain-computer interface (BMI), intracerebral stimulation (DBS), the research of nerve-related diseases, the reconstruction of nerve functions, and the application science in the aspects of artificial vision, artificial hearing, brain-controlled robot and the like. The microelectrode array in brain is mainly used for recording multichannel intracerebral electric signals and multichannel intracerebral microstimulation.
At present, the extraction method for brain signals comprises the extraction of scalp electrical signals (EEG), but the signals are weak, the resolution is poor, intracranial brain surface recording (EcoG), the signals are better, and the resolution is better. But only field potentials, and not electrical activity of individual neurons; the brain electrode has poor biocompatibility, large action area and certain damage to brain tissue, so that the brain electrode has limitation in correlation experiments.
A flexible neural electrode is disclosed in patent document CN108853717A entitled "a flexible neural electrode and a method for implanting the flexible neural electrode", and comprises a flexible substrate, a flexible insulating layer, and a conductive layer and a magnetic material layer between the flexible substrate and the flexible insulating layer; the conductive layer comprises at least one conductive wire, and the conductive wire comprises an interconnection wire, and recording sites and welding spots which are respectively positioned at two ends of the interconnection wire; the magnetic material layer comprises a plurality of magnetic material parts, and the magnetic material parts correspond to the first part interconnection wires one to one; at least one through hole is formed in the flexible insulating layer, the through holes correspond to the recording sites one to one, and the through holes penetrate through the flexible insulating layer and expose the corresponding recording sites. When the brain electrode is used, only the electrical activity of the neurons in the same depth range of a certain brain area can be stimulated and recorded, and the electrical activity of the neurons in different depths cannot be stimulated and recorded simultaneously.
Disclosure of Invention
The invention provides an ultramicro flexible linear deep brain electrode for solving the problem that the existing brain electrode cannot deeply stimulate and record the electrical activity of neurons in the same brain area when in use.
In order to achieve the purpose, the technical scheme of the invention is as follows:
an ultramicro flexible linear deep brain electrode comprises an electrode for stimulating and recording electrical activities of brain neurons, wherein the electrode comprises a plurality of electrode wires, the electrode wires are of wire-shaped structures made of platinum-iridium alloy materials, the diameters of the electrode wires are 12-13 mu m, the lengths of the electrode wires are different, the electrode wires are sequentially arrayed in parallel according to the increasing length sequence, the tips of the electrode wires are positioned on the same straight line, and the electrode wires are used for stimulating and recording the electrical activities of the brain neurons at different depths through the array;
and flexible film structures made of polyimide materials are coated between the electrode wires and on the outer side of the electrode wire array.
Further, the number of the electrode wires is 8, 16 or 32.
Further, the mass percentages of the main alloy elements of the electrode wire are as follows: pt69.5% -70%; ir29.5% -30%.
Further, when the electrode is implanted, the electrode enters a cerebral cortex, the wire electrode is in flexible contact with brain tissue, the wire electrode linearly penetrates into the brain, and the wire electrode sequentially stays at brain positions with different depths according to the length to stimulate and record brain neuron electrical activities with different depths.
Furthermore, the leading-out terminal of electrode is provided with the connector, the connector is used for electrode and external equipment to communicate.
Through the technical scheme, the invention has the beneficial effects that:
1. the brain area nerve stimulation and recording device is provided with an electrode, wherein the electrode comprises a plurality of electrode wires, the electrode wires are different in length, the electrode wires are sequentially arrayed in parallel according to the increasing length sequence, the tips of the electrode wires are positioned on the same straight line, and when the brain area nerve stimulation and recording device is implanted, the electrode wires are sequentially stopped at brain area positions with different depths according to the lengths to stimulate and record the electrical activity of brain area neurons with different depths.
2. The electrode wires are of wire-shaped structures made of platinum-iridium alloy materials, the diameters of the electrode wires are 12-13 mu m, and flexible film structures made of polyimide materials are coated between the electrode wires and on the outer sides of the electrode wire arrays. The electrode wire has stronger biocompatibility when using, can set up in the cerebral cortex for a long time, and the diameter of electrode wire is superfine, and the electrode wire has the flexibility and can bend at will to the at utmost has lightened the electrode wire and has caused the influence to the brain tissue after getting into cerebral cortex.
Drawings
FIG. 1 is a schematic diagram of the structure of an ultra-micro flexible linear deep electroencephalograph of the present invention.
Fig. 2 is a cross-sectional view taken at a-a of fig. 1 in accordance with the present invention.
Fig. 3 is a cross-sectional view taken at B-B of fig. 1 in accordance with the present invention.
Fig. 4 is a cross-sectional view taken at C-C of fig. 1 in accordance with the present invention.
The reference numbers in the drawings are as follows: 1 is an electrode, 2 is a membrane structure, and 101 is a wire electrode.
Detailed Description
The invention is further described with reference to the following figures and detailed description:
as shown in fig. 1 to 2, an ultramicro flexible linear deep brain electrode comprises an electrode 1 for stimulating and recording electrical activity of brain neurons, wherein the electrode 1 comprises a plurality of electrode wires 101, the electrode wires 101 are wire-shaped structures made of platinum-iridium alloy materials, the diameters of the electrode wires 101 are 12 to 13 μm, the lengths of the electrode wires 101 are different, the electrode wires 101 are sequentially arrayed in parallel according to the increasing length sequence, the tips of the electrode wires 101 are located on the same straight line, and the electrode wires 101 are used for stimulating and recording electrical activity of brain neurons at different depths through the array;
and flexible film structures 2 made of polyimide materials are coated among the electrode wires 101 and on the outer side of the electrode wire 101 array.
As a preferable implementation manner, in this embodiment, the diameter of the wire electrode 101 is 12.5 μm, the number of the wire electrodes 101 is 16, the diameter of the array of the 16 wire electrodes 101 is 80 to 85 μm, and the length difference between two adjacent wire electrodes 101 is 50 to 75 μm;
in order to optimize the product structure, the mass percentages of the main alloy elements of the wire electrode 101 are as follows: pt69.5% -70%; ir29.5% -30%.
When electrode 1 was implanted, electrode 1 got into cerebral cortex, wire electrode 101 and brain district tissue flexible contact, wire electrode 101 are linear and go deep into the brain district, many wire electrode 101 stops in proper order according to length in the brain district position of different degree of depth and stimulates and the record the brain district neuron electrical activity of different degree of depth.
As an implementable mode, the connector is an Omnetics 16-conducting micro connector, the outlet end of the electrode 1 is provided with the connector, and the connector is used for the electrode 1 to communicate with external equipment.
In this embodiment, when recording an acute intracerebral electrical signal and performing multichannel acute intracerebral microstimulation, an outer tube is disposed outside the membrane structure 2, the outer tube is a tubular structure made of stainless steel, the outer tube is used for assisting the electrode 1 to implant the brain, an oblique incision is disposed at the lower end of the outer tube, the lower end of the outer tube is pointed, the outer tube is movably connected with the outer surface of the membrane structure 2, and the length of the electrode 1 is greater than that of the outer tube;
when the electrode 1 is implanted, the electrode 1 is collected into the outer tube, the electrode 1 enters the cerebral cortex through the pointed end of the outer tube, then the outer tube moves downwards, and when the outer tube reaches the position 1-2 mm above the preset brain area, the movement is stopped and the outer tube is fixed. The electrode 1 is pushed downwards through the connector 2, after the electrode 1 enters the brain, the electrode wires 101 are inserted into the brain nerve fiber bundles in parallel, and 16 electrode wires 101 receive and stimulate the electrical activity of brain region neurons at different depths.
The electrode 1 sends the neuron electrical activity signal to the outside through the connector 2, the connector 2 is connected with relevant apparatus for recording, analyzing and researching the neuron electrical activity signal in the brain region, and researchers conduct relevant brain activity research on the brain region through the signal transmitted by the connector 2.
In this embodiment, when recording chronic intracerebral electrical signals and performing multichannel chronic intracerebral micro-stimulation, the outer side of the membrane structure 2 is uniformly coated with a layered structure made of carbon wax, the carbon wax layer is dissolved by itself after entering the cerebral cortex along with the electrode 1, the electrode wires 101 are inserted into the cerebral nerve fiber bundles in parallel, and 16 electrode wires 101 receive and stimulate electrical activity of brain neurons at different depths.
When the cochlear stimulation of the artificial auditory sense is carried out, the electrode 1 is inserted into the cochlea according to the steps, the wire electrode 101 has strong flexibility, the wire electrode 101 bends along the trend of the cochlea, and researchers stimulate the cochlear nerve through the connector 2.
The above-described embodiments are merely preferred embodiments of the present invention, and not intended to limit the scope of the invention, so that equivalent changes or modifications in the structure, features and principles of the invention described in the claims should be included in the claims.
Claims (5)
1. The ultramicro flexible linear deep brain electrode comprises an electrode (1) for stimulating and recording electrical activities of brain neurons, and is characterized in that the electrode (1) comprises a plurality of electrode wires (101), the electrode wires (101) are of a wire-shaped structure made of platinum-iridium alloy materials, the diameters of the electrode wires (101) are 12-13 mu m, the lengths of the electrode wires (101) are different, the electrode wires (101) are sequentially arrayed in parallel according to the increasing sequence of the lengths, the tips of the electrode wires (101) are positioned on the same straight line, and the electrode wires (101) are used for stimulating and recording the electrical activities of the brain neurons at different depths through the array;
the flexible membrane structures (2) made of polyimide materials are coated among the electrode wires (101) and on the outer side of the electrode wire (101) array.
2. The ultra micro flexible linear deep brain electrode according to claim 1, wherein the number of the electrode wires (101) is 8, 16 or 32.
3. The ultra-micro flexible linear deep brain electrode according to claim 1, wherein the wire electrode (101) comprises the following main alloy elements in percentage by mass: pt69.5% -70%; ir29.5% -30%.
4. The ultra-micro flexible linear deep brain electrode according to claim 1, wherein when the electrode (1) is implanted, the electrode (1) enters the cerebral cortex, the wire electrode (101) is in flexible contact with brain tissue, the wire electrode (101) linearly extends into the brain, and a plurality of wire electrodes (101) sequentially stay at brain positions with different depths according to the length to stimulate and record the electrical activity of brain neurons with different depths.
5. The ultra-micro flexible linear deep brain electrode according to claim 1, wherein the outlet end of the electrode (1) is provided with a connector for the electrode (1) to communicate with external devices.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911190517.0A CN111053554A (en) | 2019-11-28 | 2019-11-28 | Ultramicro flexible linear deep brain electrode |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911190517.0A CN111053554A (en) | 2019-11-28 | 2019-11-28 | Ultramicro flexible linear deep brain electrode |
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| CN201911190517.0A Pending CN111053554A (en) | 2019-11-28 | 2019-11-28 | Ultramicro flexible linear deep brain electrode |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112244850A (en) * | 2020-09-29 | 2021-01-22 | 中国科学院上海微系统与信息技术研究所 | Intracranial deep electrode recording device and preparation method and system thereof |
| CN114190948A (en) * | 2021-12-14 | 2022-03-18 | 深圳先进技术研究院 | Manufacturing method and using method of multi-brain-area recording electrode array capable of being implanted for long time |
| CN114795230A (en) * | 2022-03-29 | 2022-07-29 | 北京理工大学 | Implantable wireless neural sensor for recording electroencephalogram signals |
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