CN110927252B - Targeted shear wave elastography detection method - Google Patents
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- 238000001514 detection method Methods 0.000 title claims abstract description 34
- 238000002099 shear wave elastography Methods 0.000 title claims abstract description 20
- 238000003384 imaging method Methods 0.000 claims abstract description 39
- 238000012360 testing method Methods 0.000 claims abstract description 35
- 239000006249 magnetic particle Substances 0.000 claims abstract description 28
- 230000005284 excitation Effects 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims description 12
- 238000006073 displacement reaction Methods 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 8
- 238000002091 elastography Methods 0.000 claims description 7
- 240000008042 Zea mays Species 0.000 claims description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 6
- 235000005822 corn Nutrition 0.000 claims description 6
- 238000012285 ultrasound imaging Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 229910001566 austenite Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000010606 normalization Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- 239000000523 sample Substances 0.000 abstract description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 241000282894 Sus scrofa domesticus Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 230000003247 decreasing effect Effects 0.000 description 1
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- 229910000859 α-Fe Inorganic materials 0.000 description 1
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/04—Analysing solids
- G01N29/06—Visualisation of the interior, e.g. acoustic microscopy
- G01N29/0654—Imaging
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/44—Processing the detected response signal, e.g. electronic circuits specially adapted therefor
- G01N29/50—Processing the detected response signal, e.g. electronic circuits specially adapted therefor using auto-correlation techniques or cross-correlation techniques
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- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/04—Wave modes and trajectories
- G01N2291/042—Wave modes
- G01N2291/0422—Shear waves, transverse waves, horizontally polarised waves
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Abstract
The invention provides a targeted shear wave elastography detection method, magnetic particles are injected into a test body, and the test body is placed between an ultrasonic transducer and an excitation coil; the function generator transmits square waves to the power amplifier, and simultaneously transmits a trigger signal to the ultrasonic imaging system; the power amplifier amplifies the square wave, and the exciting coil generates a pulse magnetic field to act on the test body, and the magnetic field drives magnetic particles in the test body to vibrate; triggering an ultrasonic transducer to work by the ultrasonic imaging system, and receiving a reflected pulse by the ultrasonic transducer to form a radio-frequency echo signal; the ultrasonic imaging system collects radio frequency echo signals from the ultrasonic transducer, demodulates and images the radio frequency echo signals, and calculates to obtain a shear wave speed c and a shear modulus G. The invention uses magnetic particles as the probe to be used as the mark, can effectively improve the penetrability of the excitation signal in a complex environment, and has accurate and reliable detection result of shear wave elastography detection.
Description
Technical Field
The invention relates to elastography, and particularly discloses a targeted shear wave elastography detection method.
Background
Ultrasonic elastography can be classified into quasi-static elastography, low-frequency vibration elastography, shear wave elastography, acoustic radiation force pulse imaging, rapid shear wave imaging, etc. according to the excitation mode. These imaging methods primarily quantify the shear modulus of tissue by measuring the shear wave velocity of the region of interest. Generally, the greater the hardness of the test body, the greater the shear wave velocity and shear modulus thereof.
Shear wave elastography is generally obtained by processing through an ultrasonic imaging system, an elastography detection system in the prior art mainly tests a test body through an ultrasonic transducer, and then the ultrasonic imaging system collects information to conduct shear wave elastography.
Disclosure of Invention
Based on the above, it is necessary to provide a targeted shear wave elastography detection method, which can effectively improve the reliability of the shear wave elastography detection result.
In order to solve the problems in the prior art, the invention discloses a targeted shear wave elastography detection method, which comprises a function generator, wherein the output end of the function generator is respectively connected with a power amplifier and an ultrasonic imaging system, the output end of the power amplifier is connected with an excitation coil, the data acquisition end of the ultrasonic imaging system is connected with an ultrasonic transducer, and a test body containing magnetic particles is arranged between the excitation coil and the ultrasonic transducer, and the method comprises the following steps:
step one, magnetic particles are injected into a test body, and the test body is placed between an ultrasonic transducer and an excitation coil;
step two, the function generator transmits square waves to the power amplifier, and simultaneously transmits a trigger signal to the ultrasonic imaging system;
step three, amplifying the square wave by a power amplifier to obtain an amplified square wave, and generating a pulse magnetic field by an excitation coil under the excitation of the amplified square wave to act on a test body, wherein the magnetic field drives magnetic particles in the test body to vibrate;
triggering an ultrasonic transducer to work by the ultrasonic imaging system, enabling the ultrasonic transducer to emit detection pulses to act on a test body to form reflection pulses, and enabling the ultrasonic transducer to receive the reflection pulses to form radio-frequency echo signals;
and fifthly, the ultrasonic imaging system acquires radio frequency echo signals from the ultrasonic transducer, demodulates and images the radio frequency echo signals, and calculates and obtains the shear wave speed c and the shear modulus G.
Further, the ultrasound imaging system is a Verasonics system.
Further, the ultrasonic transducer is a linear array ultrasonic transducer.
Further, in the second step, the square wave pulse width emitted by the function generator is 1ms.
Further, in the third step, the power amplifier amplifies the square wave by 20dB to obtain an amplified square wave.
In the fourth step, the center frequency of the ultrasonic transducer transmitting detection pulse is 5MHz, the repetition frequency is 10kHz, the number of the composite angles is 5, and the effective detection frequency is 2kHz.
Further, in the fifth step, the method for calculating the shear wave velocity c and the shear modulus G by the ultrasonic imaging system includes:
wherein ,
is the average displacement in a given axial range, M is the number of samples in the vertical direction, N is the number of samples in the time direction, f c For the center frequency of the rf signal, I and Q are the in-phase and quadrature components, respectively, of the rf echo signal after demodulation, ρ being the density of the test volume.
The beneficial effects of the invention are as follows: the invention discloses a targeted shear wave elastography detection method, which uses magnetic particles as a probe to be used as a mark, and the magnetic particles vibrate under the action of a magnetic field emitted by an excitation coil, so that the shear wave propagation of surrounding structures of the magnetic particles is caused, the penetrability of excitation signals in a complex environment can be effectively improved, the vibration and shear wave propagation information of the magnetic particles can be accurately and reliably obtained through an ultrasonic transducer, the sensitivity of the whole system is effectively improved, an ultrasonic imaging system can obtain the distribution of the magnetic particles and the elasticity information of the surrounding structures of the magnetic particles, and the detection result of the shear wave elastography detection is accurate and reliable.
Drawings
FIG. 1 is a schematic diagram of a targeted shear wave elastography detection system according to the present invention.
Fig. 2 is a schematic flow chart of demodulation imaging of the ultrasonic imaging system in the invention.
FIG. 3 is an image of a conventional method test and a test of the present invention.
Fig. 4 is a graph showing vibration displacement at different detection points during detection according to the present invention.
The reference numerals are: a function generator 10, a power amplifier 20, an ultrasound imaging system 30, an excitation coil 40, an ultrasound transducer 50, a test volume 60.
Detailed Description
The invention will be further described in detail with reference to the drawings and the detailed description below, in order to further understand the features and technical means of the invention and the specific objects and functions achieved.
Reference is made to fig. 1 to 4.
The embodiment of the invention discloses a targeted shear wave elastography detection method, which comprises a function generator 10, wherein the output end of the function generator 10 is respectively connected with a power amplifier 20 and an ultrasonic imaging system 30, the output end of the power amplifier 20 is connected with an excitation coil 40, the data acquisition end of the ultrasonic imaging system 30 is connected with an ultrasonic transducer 50, and a test body 60 containing magnetic particles is arranged between the excitation coil 40 and the ultrasonic transducer 50.
In this embodiment, the ultrasound imaging system 30 is a Verasonics system in the united states, which allows a developer to customize any of the component functions of the entire ultrasound system by means of a friendly and powerful MATLAB compiling environment, enabling rapid data acquisition based on plane wave pulse emissions.
In the present embodiment, the ultrasonic transducer 50 is a linear array ultrasonic transducer 50 of model L7-4.
The targeted shear wave elastography detection method sequentially comprises the following steps:
step one, magnetic particles are injected into a test body 60, wherein the magnetic particles are equivalent to image probes and are used for improving the sensitivity and accuracy of elastic imaging, and the test body 60 is placed between an ultrasonic transducer 50 and an exciting coil 40;
step two, the function generator 10 transmits square waves to the power amplifier 20, and the function generator 10 simultaneously transmits trigger signals to the ultrasonic imaging system 30;
step three, the power amplifier 20 amplifies the square wave to obtain an amplified square wave, and the exciting coil 40 generates a pulse magnetic field to act on the test body 60 under the excitation of the amplified square wave, and the magnetic field drives magnetic particles in the test body 60 to vibrate;
step four, the ultrasonic imaging system 30 triggers the ultrasonic transducer 50 to work, the ultrasonic transducer 50 transmits detection pulses to act on the test body 60 under the action of the pulse magnetic field to form reflected pulses, and the ultrasonic transducer 50 receives the reflected pulses to form radio-frequency echo signals;
step five, the ultrasonic imaging system 30 collects the radio frequency echo signals from the ultrasonic transducer 50, demodulates and images the radio frequency echo signals, and calculates to obtain the shear wave velocity c and the shear modulus G of the test body 60.
In the fifth embodiment, as shown in fig. 2, the method for demodulating and imaging the radio-frequency echo signal by the ultrasonic imaging system 30 specifically includes:
A. IQ demodulation is carried out on the radio frequency echo signals, and demodulation signals are obtained;
B. envelope and autocorrelation are calculated on the demodulated signal;
C. sequentially carrying out normalization, logarithmic compression and structural imaging on the signals subjected to the wrapping;
D. sequentially performing centroid positioning, median filtering and magnetomotive imaging on the signal after the autocorrelation;
E. and obtaining the mass point vibration speed from the self-correlated signal, and sequentially carrying out direction filtering, speed fitting and elastography on the mass point vibration speed.
In the present embodiment, in the second step, the square wave pulse width emitted by the function generator 10 is 1ms.
In the present embodiment, in step three, the power amplifier 20 amplifies the square wave by 20dB to obtain an amplified square wave.
In the present embodiment, in the fourth step, the ultrasonic transducer 50 emits the detection pulse with a center frequency of 5MHz, a repetition frequency of 10kHz, a number of compound angles of 5, and an effective detection frequency of 2kHz.
In the fifth embodiment, the method for calculating the shear wave velocity c and the shear modulus G by the ultrasonic imaging system 30 is as follows:
wherein ,
is the average displacement in a given axial range, M is the number of samples in the vertical direction, i.e. the depth direction, N is the number of samples in the time direction, i.e. the number of frames, f c For the center frequency of the rf signal, I and Q are in-phase and quadrature components of the rf echo signal after IQ demodulation, the same excitation method is repeated for each of the simulants, and the obtained multiple sets of data are superimposed to improve the signal-to-noise ratio of the vibration displacement detection signal, where ρ is the density of the test body 60.
Detection was performed using conventional methods and methods of the invention:
preparing imitation body, mixing Corii Sus Domestica powder, corn flour and deionized waterThe weight of the sub water is 5:5:100, and after microwave heating to dissolve pigskin powder and corn powder, placing the pigskin powder and corn powder in a body-imitating mold for cooling to obtain hollow gel. Mixing the partially heated and dissolved imitation solution with magnetic particle gamma-Fe 2 O 3 And non-magnetic particles alpha-Fe 2 O 3 The magnetic particles and the non-magnetic particles were mixed to have particle diameters of 10nm, the concentration of the prepared particles was 10mg/ml, and then they were respectively poured into gels having a hollow region diameter of 3mm to obtain a dummy, which was used as the test body 60.
The region of greater acoustic impedance difference is first scanned by a conventional B-mode ultrasound imaging system to obtain a cross-sectional area of the particle marker. As shown in fig. 3 a1-a3, both the magnetic and non-magnetic particle labelled areas show a strong acoustic reflection signal. The results also indicate that single structure imaging in the conventional method is susceptible to interference from other occupancy information.
By the detection of the method, the vibration distribution of the magnetic particles can be obtained through the excitation of a pulse magnetic field and the acquisition and the processing of vibration signals, and the magnetic particles have good signal to noise ratio, as shown in a figure 3 b. Comparing a1, a2, a3 and b in fig. 3, the position of the vibration source can be clearly located, as shown in c in fig. 3. Vibration information of surrounding tissues is acquired and analyzed while the vibration source position is obtained, and the time intervals of the parts b and c in fig. 3 from the excitation signal are respectively 0.5ms, 1.5ms and 2.5ms and 3.5ms. The results show a more pronounced shear wave propagation. Then, the change curves of vibration displacement with time are calculated for three different positions in the process of propagation of the shear wave, and the result is that the distance between two adjacent points is 0.308mm as shown in fig. 4, in the process of propagation of the shear wave, a certain time delay exists between the displacement curve of a far particle and the displacement curve of a near particle in phase, and the displacement amplitude shows a decreasing trend. Based on the above, the time difference between each point and the peak displacement is calculated by analyzing the vibration phase diagrams at different positions on the vibration source straight line, and then the linear fitting is carried out, so that the shear wave speed of the imitation body is 3.669m/s, the density of the imitation body is about 1.3Kg/L, and the shear modulus of the imitation body is about 17.5Kpa. The hardness of the test body 60 can be reflected in terms of shear wave velocity and shear modulus.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (5)
1. The targeted shear wave elastography detection method is characterized by comprising a function generator (10), wherein the output end of the function generator (10) is respectively connected with a power amplifier (20) and an ultrasonic imaging system (30), the output end of the power amplifier (20) is connected with an excitation coil (40), the data acquisition end of the ultrasonic imaging system (30) is connected with an ultrasonic transducer (50), a test body (60) internally containing magnetic particles is arranged between the excitation coil (40) and the ultrasonic transducer (50),
the method comprises the following steps:
step one, magnetic particles are injected into a test body (60), and the test body (60) is placed between an ultrasonic transducer (50) and an exciting coil (40); preparing imitation body, namely mixing pigskin powder, corn flour and deionized water according to the mass ratio of 5:5:100, after the pigskin powder and the corn powder are dissolved by microwave heating, placing the pigskin powder and the corn powder in a body-imitating mold, and cooling to obtain hollow gel; taking a heated and dissolved imitation solution and magnetic particle gamma-Fe 2 O 3 Mixing, wherein the particle size of the magnetic particles is 10nm, the concentration of the prepared particles is 10mg/ml, and then pouring the particles into gel with the hollow area diameter of 3mm to obtain a simulated body which is used as a test body;
step two, the function generator (10) transmits square waves to the power amplifier (20), and the function generator (10) simultaneously transmits trigger signals to the ultrasonic imaging system (30); the square wave pulse width emitted by the function generator (10) is 1ms;
step three, the power amplifier (20) amplifies square waves to obtain amplified square waves, the exciting coil (40) generates a pulse magnetic field to act on the test body (60) under the excitation of the amplified square waves, and the magnetic field drives magnetic particles in the test body (60) to vibrate;
step four, the ultrasonic imaging system (30) triggers the ultrasonic transducer (50) to work, the ultrasonic transducer (50) transmits detection pulses to act on the test body (60) to form reflection pulses, and the ultrasonic transducer (50) receives the reflection pulses to form radio-frequency echo signals; the ultrasonic transducer (50) transmits detection pulses with a center frequency of 5MHz, a repetition frequency of 10kHz, a number of compound angles of 5 and an effective detection frequency of 2kHz;
step five, the ultrasonic imaging system (30) collects radio frequency echo signals from the ultrasonic transducer (50), demodulates and images the radio frequency echo signals, and calculates to obtain a shear wave speed c and a shear modulus G;
in the fifth step, the demodulation imaging method of the ultrasonic imaging system for the radio-frequency echo signal specifically comprises the following steps:
A. IQ demodulation is carried out on the radio frequency echo signals, and demodulation signals are obtained;
B. envelope and autocorrelation are calculated on the demodulated signal;
C. sequentially carrying out normalization, logarithmic compression and structural imaging on the signals subjected to the wrapping;
D. sequentially performing centroid positioning, median filtering and magnetomotive imaging on the signal after the autocorrelation;
E. and obtaining the mass point vibration speed from the self-correlated signal, and sequentially carrying out direction filtering, speed fitting and elastography on the mass point vibration speed.
2. The targeted shear wave elastography detection method of claim 1, wherein the ultrasound imaging system (30) is a Verasonics system.
3. The targeted shear wave elastography detection method of claim 1, wherein the ultrasound transducer (50) is a linear array ultrasound transducer (50).
4. The targeted shear wave elastography detection method according to claim 1, wherein in the third step, the power amplifier (20) amplifies the square wave by 20dB to obtain an amplified square wave.
5. The method according to claim 1, wherein in the fifth step, the method for calculating the shear wave velocity c and the shear modulus G by the ultrasonic imaging system (30) comprises the following steps:
wherein ,
is the average displacement in a given axial range, M is the number of samples in the vertical direction, N is the number of samples in the time direction, f c For the center frequency of the RF signal, I and Q are the in-phase and quadrature components, respectively, of the RF echo signal after demodulation, ρ being the density of the test volume (60). />
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| CN113768543B (en) * | 2021-09-15 | 2024-03-22 | 南京超维景生物科技有限公司 | Ultrasound contrast imaging method and system |
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| EP1293132A4 (en) * | 2000-06-14 | 2003-08-27 | San Ei Gen Ffi Inc | Novel gel compositions and utilization thereof |
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| CN109730722B (en) * | 2019-02-27 | 2021-04-27 | 天津大学 | Elastic imaging method based on focused ultrasonic acoustic vibration signal |
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| JPH02195952A (en) * | 1989-01-26 | 1990-08-02 | Olympus Optical Co Ltd | Ultrasonic wave diagnostic device |
| JP2004000620A (en) * | 2003-05-19 | 2004-01-08 | Toshiba Corp | Ultrasonic diagnostic system |
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