CN110585546A - Respiratory mask with hypoglossal nerve and diaphragm muscle stimulation function and ventilation treatment equipment - Google Patents
Respiratory mask with hypoglossal nerve and diaphragm muscle stimulation function and ventilation treatment equipment Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
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- A61B5/4818—Sleep apnoea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K7/00—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements
- G01K7/16—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements
- G01K7/22—Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat ; Power supply therefor, e.g. using thermoelectric elements using resistive elements the element being a non-linear resistance, e.g. thermistor
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Abstract
The invention discloses a respiratory mask with hypoglossal nerve and diaphragm muscle stimulation functions and ventilation treatment equipment, wherein the respiratory mask comprises a mask body, a respiratory state monitoring device arranged at the bottom of the mask body, and a hypoglossal stimulation electrode and a diaphragm muscle stimulation electrode which are connected with the respiratory state monitoring device, wherein the mask body is communicated with the respiratory state monitoring device through a thin tube; the respiratory state monitoring device comprises a protective shell, a sensor detection circuit arranged in the protective shell, a CPU controller and a stimulation pulse circuit; the sensor detection circuit detects pressure, temperature, blood oxygen saturation and heart rate data of the wearer respiratory airflow introduced into the protective shell and transmits the data to the CPU controller; the CPU controller judges whether the wearer has obstructive apnea and central apnea, and triggers the stimulation pulse circuit to stimulate the hypoglossal nerve to contract the genioglossus muscle and the diaphragm muscle.
Description
Technical Field
The invention relates to the technical field of breathing masks, in particular to a breathing mask with hypoglossal nerve and diaphragm muscle stimulation functions and ventilation treatment equipment.
Background
Sleep is closely related to many activities of the body. With the universal acceleration of the life rhythm of people, the incidence rate of sleep disordered breathing is higher and higher, the sleep disordered breathing is a source disease of internal medicine chronic diseases, and the sleep disordered breathing brings serious influence on the health and the life quality of people. Sleep disordered breathing is divided into Obstructive Sleep Apnea (OSAHS), central sleep apnea, and mixed sleep apnea. Among them, OSAHS is the most common sleep disordered breathing, which refers to a disease of apnea or hypopnea, repeated hypoxemia, hypercapnia, repeated arousal state and structural disorder of sleep, and decreased sleep quality due to repeated complete or partial obstruction or collapse of the upper airway.
Currently, the standard first line treatment for OSAHS is CPAP. Although many manufacturers of noninvasive ventilators develop new ventilation techniques to improve patient comfort, they have their own drawbacks: the price is high, and the product is not easy to popularize and use in developing countries; the instrument has larger volume, is not easy to carry about, and is particularly inconvenient for people who frequently go on business; the connecting pipeline limits the night activity of the patient, and the compliance is reduced; continuous positive pressure means that continuous airflow is present, causing discomfort to most patients, so that a significant number of patients cannot tolerate the treatment.
Disclosure of Invention
In order to overcome the defects of the prior art, the present disclosure provides a respiratory mask and a ventilation therapy device with hypoglossal nerve and diaphragm muscle stimulation functions, which have hypoglossal nerve stimulation and diaphragm muscle pacing functions.
The technical scheme adopted by the disclosure is as follows:
a respiratory mask with hypoglossal nerve and diaphragmatic muscle stimulation functions comprises a mask body, a respiratory state monitoring device arranged at the bottom of the mask body, and a hypoglossal stimulation electrode and a diaphragmatic muscle stimulation electrode which are connected with the respiratory state monitoring device, wherein the mask body is communicated with the respiratory state monitoring device through a thin tube;
the respiratory state monitoring device comprises a protective shell, a sensor detection circuit arranged in the protective shell, a CPU controller and a stimulation pulse circuit; the sensor detection circuit detects pressure, temperature, blood oxygen saturation and heart rate data of the wearer respiratory airflow introduced into the protective shell and transmits the data to the CPU controller;
the CPU controller judges whether the detected temperature and pressure of the breathing airflow of the wearer change in a set time period, if not, the CPU controller judges that the wearer has obstructive apnea, controls the stimulation pulse circuit to generate a sublingual stimulation pulse signal and transmits the sublingual stimulation pulse signal to the sublingual stimulation electrode, and stimulates the sublingual nerve to contract the genioglossus muscle through the sublingual stimulation electrode; judge whether the oxyhemoglobin saturation and the heart rate of the wearer are lower than the set value, if the oxyhemoglobin saturation and the heart rate of the wearer are lower than the set value, and the temperature and the pressure of the breathing airflow of the wearer are still unchanged in the set time period, judge that the wearer has central breathing pause, control the stimulation pulse circuit to generate a diaphragm stimulation pulse signal and transmit the signal to the diaphragm stimulation electrode, and stimulate the diaphragm to shrink through the diaphragm stimulation electrode.
Furthermore, respiratory pressure detection circuitry includes pressure sensor, first amplifier, second amplifier, third amplifier and fourth amplifier, a pressure sensor's an input is connected with the input of third amplifier, another input of pressure sensor is connected with the output of third amplifier, two outputs of pressure sensor are connected with the normal phase input of first amplifier and second amplifier respectively, the output of first amplifier and second amplifier is connected with the input of fourth amplifier through resistance respectively, the output and the CPU controller of fourth amplifier are connected.
Furthermore, the breath temperature monitoring circuit comprises a temperature sensor, a fifth amplifier, a sixth amplifier, a seventh amplifier, an eighth amplifier and a steady-state trigger;
the output end of the temperature sensor sequentially passes through a fifth amplifier, a sixth amplifier and a seventh amplifier which are connected in parallel and is connected with the positive input end of an eighth amplifier, the negative input end of the eighth amplifier is also connected with the output end of the temperature sensor, the output end of the eighth amplifier is connected with the input end of a steady trigger, and the output end of the steady trigger is connected with a CPU controller.
Further, blood oxygen heart rate detection circuitry includes heart rate blood oxygen sensor, the output and the CPU controller of heart rate blood oxygen sensor are connected, detect the oxyhemoglobin saturation and the heart rate of the person of wearing to transmit for the CPU controller.
Further, the stimulation pulse circuit comprises a stimulation pulse generating circuit and a stimulation pulse adjusting circuit;
the stimulation pulse generating circuit comprises a sublingual stimulation pulse generating circuit and a diaphragmatic muscle stimulation pulse generating circuit, wherein the input end of the sublingual stimulation pulse generating circuit is connected with the CPU controller, and the output end of the sublingual stimulation pulse generating circuit is connected with a sublingual stimulation electrode, and is used for receiving a control instruction output by the CPU controller, generating a sublingual stimulation pulse signal and outputting the sublingual stimulation pulse signal to the sublingual stimulation electrode; the input end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the CPU controller, and the output end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the diaphragmatic muscle stimulation electrode and is used for receiving a control instruction output by the CPU controller, generating a diaphragmatic muscle stimulation pulse signal and outputting the diaphragmatic muscle stimulation pulse signal to the diaphragmatic muscle stimulation electrode; the stimulation pulse adjusting circuit is connected with a pulse width modulation interface of the CPU controller, so that the sublingual stimulation pulse signal and the diaphragm stimulation pulse signal intensity can be adjusted.
Furthermore, the stimulation pulse circuit also comprises a power supply circuit, and the power supply circuit is connected with the stimulation pulse generating circuit and is used for providing required power supply for the stimulation pulse generating circuit.
Further, diaphragm muscle stimulation pulse produces the circuit and includes first triode and first transformer, the base of first triode is passed through resistance and is connected with the CPU controller, the collecting electrode of first triode passes through diode and resistance and is connected with the one end of the primary coil of first transformer, the collecting electrode of first triode still directly is connected with the other end of the primary coil of first transformer, the secondary coil and the diaphragm muscle stimulation electrode of first transformer are connected.
Furthermore, the sublingual stimulation pulse generating circuit comprises a second triode and a second transformer, wherein the base electrode of the second triode is connected with the CPU controller through a resistor, the collector electrode of the second triode is connected with one end of the primary coil of the second transformer through a diode and a resistor, and the secondary coil of the second transformer is connected with the sublingual stimulation electrode.
Furthermore, the stimulation pulse regulating circuit comprises a two-way operational amplifier and a third triode, wherein a positive phase input end of the two-way operational amplifier is connected with the CPU controller through an RC filter, a positive phase output end of the two-way operational amplifier is connected with another positive phase input end of the two-way operational amplifier, and another output end of the two-way operational amplifier is connected with the third triode through a resistor.
A ventilation therapy device comprises a main machine for generating therapeutic gas and a breathing mask communicated with an air outlet of the main machine.
Through above-mentioned technical scheme, this disclosed beneficial effect is:
(1) the present disclosure has good effects on both obstructive and central apneas; the hypoglossal nerve and diaphragm muscle stimulation is in vitro stimulation, the stimulation intensity can be adjusted, the compliance is good, no noise exists, and the sleep of a patient is not influenced.
(2) The respiratory pressure detection circuit, the respiratory temperature detection circuit and the blood oxygen heart rate detection circuit are used for detecting the respiratory airflow pressure, the temperature, the blood oxygen saturation and the heart rate of a wearer, so that whether obstructive apnea occurs to the wearer can be judged in time, if yes, the stimulation pulse circuit can be triggered in time to stimulate hypoglossal nerve to contract genioglossus muscle, and the obstructive apnea event is solved; whether central apnea happens to the wearer can be judged in time, if the central apnea happens, the stimulation pulse circuit can be triggered in time to stimulate the diaphragm to contract, and the central apnea event is solved.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this disclosure, are included to provide a further understanding of the disclosure, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the disclosure and together with the description serve to explain the application and not to limit the disclosure.
FIG. 1 is a block diagram of a respiratory mask with hypoglossal nerve and diaphragm stimulation according to an embodiment;
FIG. 2 is a circuit diagram of a respiratory pressure detection circuit according to an embodiment;
FIG. 3 is a circuit diagram of a breath temperature detection circuit according to an embodiment;
FIG. 4 is a circuit diagram of a blood oxygen heart rate detection circuit according to an embodiment;
FIG. 5 is a circuit diagram of a CPU controller according to one embodiment;
FIG. 6(a) is a circuit diagram of a diaphragm stimulation pulse generation circuit according to an embodiment;
FIG. 6(b) is a circuit diagram of a sublingual stimulation pulse generating circuit in accordance with one embodiment;
FIG. 7 is a circuit diagram of a stimulation pulse conditioning circuit according to one embodiment;
FIG. 8 is a circuit diagram of a power circuit according to an embodiment.
Detailed Description
The present disclosure is further described with reference to the following drawings and examples.
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
Example one
The embodiment provides a breathing mask with hypoglossal nerve and diaphragm muscle stimulation function, please refer to fig. 1, the breathing mask comprises a mask body 1 and a breathing state monitoring device 3, the bottom of the mask body 1 is fixedly connected with the breathing state monitoring device 3, the mask body 1 is communicated with the breathing state monitoring device 3 through a thin tube 2, airflow in the mask body 1 enters the breathing state monitoring device 3 through the thin tube 2, the breathing state monitoring device 3 detects the temperature and pressure of the breathing airflow of a wearer and the blood oxygen saturation and heart rate of the wearer, judges whether the wearer has obstructive apnea, and if yes, stimulates the hypoglossal nerve to contract genioglossus muscle; judging whether the wearer has central apnea, and if so, stimulating phrenic nerve to treat the central apnea.
Referring to the attached drawing 1, the respiratory state monitoring device 3 comprises a protective shell 4, a sensor detection circuit, a CPU controller, a stimulation pulse circuit, a sublingual stimulation electrode and a diaphragmatic muscle stimulation electrode 9 which are arranged in the protective shell 4, wherein the sublingual stimulation electrode and the diaphragmatic muscle stimulation electrode are connected with the stimulation pulse circuit, the protective shell 4 is communicated with the mask body 1 through a thin tube 2, the input end of the CPU controller is connected with the sensor detection circuit, and the output end of the CPU controller is connected with the stimulation pulse circuit.
The sensor detection circuit comprises a respiratory pressure detection circuit, a respiratory temperature detection circuit and a blood oxygen heart rate detection circuit.
Referring to fig. 2, the respiratory pressure detection circuit includes a pressure sensor U12, a first amplifier U8, a second amplifier U13, a third amplifier U9 and a fourth amplifier U14, an input end of the pressure sensor U12 is connected to an input end of the third amplifier U9, another input end of the pressure sensor U12 is connected to an output end of the third amplifier U9, an output end of the pressure sensor U12 is connected to a non-inverting input end of the first amplifier U8, another output end of the pressure sensor U12 is connected to a non-inverting input end of the second amplifier U13, an output end of the first amplifier U8 is connected to an inverting input end of the fourth amplifier U14 through a resistor, an output end of the second amplifier U8 is connected to a non-inverting input end of the fourth amplifier U14 through a resistor, and an output end of the fourth amplifier U14 is connected to the CPU controller.
When the respiratory pressure detection circuit provided by the embodiment is used, a pressure signal of the respiratory airflow of a wearer is detected by the pressure sensor U12, amplified by the first amplifier U8, the second amplifier U13, the third amplifier U9 and the fourth amplifier U14 and transmitted to the CPU controller.
In the present embodiment, the pressure sensor U12 is an MPS2107006 type pressure sensor.
Referring to fig. 3, the respiration temperature monitoring circuit includes an NTC temperature sensor, a fifth amplifier U10B, a sixth amplifier U10A, a seventh amplifier U15A, an eighth amplifier U15B and a steady-state flip-flop U14, an output end of the temperature sensor is connected to an input end of the fifth amplifier U10B, an output end of the fifth amplifier U10B is connected to input ends of the sixth amplifier U10A and the seventh amplifier U15A, output ends of the sixth amplifier U10A and the seventh amplifier U15A are connected to a non-inverting input end of the eighth amplifier U15B, an inverting input end of the eighth amplifier U15B is connected to an output end of the temperature sensor, an output end of the eighth amplifier U15B is connected to an input end of the steady-state flip-flop U14, and an output end of the steady-state flip-flop U14 is connected to the CPU controller.
When the respiratory temperature monitoring circuit provided by the embodiment is used, the temperature sensor detects the temperature signal of the respiratory airflow of the wearer, and the temperature signal is amplified by the fifth sensor U10B, the sixth sensor U10A, the seventh sensor U15A and the eighth sensor U15B and is transmitted to the CPU controller after being stabilized by the steady trigger U14.
Referring to fig. 4, the blood oxygen and heart rate detection circuit includes a heart rate and blood oxygen sensor, an output end of the heart rate and blood oxygen sensor is connected to the CPU controller, detects the blood oxygen saturation and the heart rate of the wearer, and transmits the detected blood oxygen saturation and heart rate to the CPU controller.
In this embodiment, the heart rate blood oxygen sensor adopts a MAX30100 type heart rate blood oxygen sensor, and can read heart rate and blood oxygen data.
The input end of the CPU controller is connected with the respiratory pressure detection circuit, the respiratory temperature detection circuit and the blood oxygen heart rate detection circuit, the output end is connected with the stimulation pulse circuit, is used for receiving the pressure data of the respiratory airflow of the wearer detected by the respiratory pressure detection circuit, the temperature data of the respiratory airflow of the wearer detected by the respiratory temperature detection circuit, the blood oxygen saturation data and the heart rate data of the wearer detected by the blood oxygen heart rate detection circuit, judging whether the detected temperature and pressure of the respiratory airflow of the wearer change in a set time period, if the detected temperature and pressure of the respiratory airflow of the wearer do not change in the set time period, judging that the wearer has obstructive apnea, controlling a stimulation pulse circuit to generate an electric pulse signal and transmit the electric pulse signal to a sublingual stimulation electrode, and stimulating the sublingual nerve to contract the genioglossus muscle through the sublingual stimulation electrode; judging whether the oxyhemoglobin saturation and the heart rate of the wearer are lower than set values or not, if the oxyhemoglobin saturation and the heart rate of the wearer are lower than the set values, and if the temperature and the pressure of the breathing airflow of the wearer are not changed in the set time period, judging that the wearer has central apnea, controlling a stimulation pulse circuit to generate electric pulse signals and transmit the electric pulse signals to a diaphragm stimulation electrode, and stimulating the diaphragm to contract through the diaphragm stimulation electrode.
Referring to fig. 5, the CPU controller may adopt an STM32F405 single chip microcomputer, and has high performance, low cost, low power consumption, and strong processing and control capabilities.
Specifically, the stimulation pulse circuit comprises a stimulation pulse generating circuit, a stimulation pulse adjusting circuit and a power supply circuit; the stimulation pulse generating circuit comprises a sublingual stimulation pulse generating circuit and a diaphragmatic muscle stimulation pulse generating circuit, wherein the input end of the sublingual stimulation pulse generating circuit is connected with a CPU (central processing unit) controller, the output end of the sublingual stimulation pulse generating circuit is connected with a sublingual stimulation electrode, and is used for receiving a control instruction output by the CPU controller, generating a sublingual stimulation pulse signal and outputting the sublingual stimulation pulse signal to the sublingual stimulation electrode, placing the sublingual stimulation electrode at a branch of a chin-tongue muscle innervated by a sublingual nerve on the body surface, and stimulating the sublingual nerve of a wearer to contract the chin-tongue muscle through the sublingual stimulation electrode; the input end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the CPU controller, the output end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the diaphragmatic muscle stimulation electrode and is used for receiving a control instruction output by the CPU controller, a generated diaphragmatic muscle stimulation pulse signal is output to the diaphragmatic muscle stimulation electrode, the diaphragmatic nerve stimulation electrode is placed at the lower edge 1/2-1/3 of the bilateral sternocleidomastoid muscle, and the diaphragmatic muscle of a wearer is stimulated to contract through the diaphragmatic muscle; the stimulation pulse adjusting circuit is connected with a Pulse Width Modulation (PWM) interface of the CPU controller, so that the sublingual stimulation pulse signal and the diaphragm stimulation pulse signal intensity are adjusted; the power supply circuit is connected with the stimulation pulse generating circuit and is used for providing required power supply for the stimulation pulse generating circuit.
In this embodiment, the sublingual and diaphragmatic stimulation pulses generated by the stimulation pulse circuit ensure that a wearer is not painful and aroused when being electrically stimulated, and also ensure that the genioglossus muscle or the diaphragmatic muscle contracts to ensure smooth breathing, and the width of the stimulation pulses is set to be 10-1000 mus, the frequency is 1-100HZ, the circuit is 0-5mA, and the voltage is 0-10V.
Referring to fig. 6(a), the diaphragm stimulation pulse generating circuit includes a first transistor Q1 and a first transformer T1, a base of the first transistor Q1 is connected to an I/O port of the CPU controller through a resistor R4, a collector of the first transistor Q1 is connected to one end of a primary coil of the first transformer T1 through a diode D1 and a resistor R1, the collector of the first transistor Q1 is also directly connected to the other end of the primary coil of the first transformer T1, and a secondary coil of the first transformer T1 is connected to the diaphragm stimulation electrode.
The CPU controller output signal flows to a first triode Q1 through a current limiting resistor R4, the first triode Q1 is conducted, the signal is amplified through the first triode Q1 and then output to a transformer T1, the voltage is regulated through a transformer T1, then a stimulation signal is output to a diaphragm stimulation electrode, and the diaphragm stimulation electrode stimulates the contraction of the diaphragm of a wearer.
Referring to fig. 6(b), the sublingual stimulation pulse generating circuit includes a second transistor Q2 and a second transformer T2, a base of the second transistor Q2 is connected to an I/O port of the CPU controller through a resistor R13, a collector of the second transistor Q2 is connected to one end of a primary winding of the transformer T2 through a diode D2 and a resistor R7, the collector of the second transistor Q2 is also directly connected to the other end of the primary winding of the second transformer T2, and a secondary winding of the second transformer T2 is connected to the sublingual stimulation electrode.
The output signal of the CPU controller flows to a second triode Q2 through a current limiting resistor R13, the second triode Q2 is conducted, the signal is amplified through the second triode Q2 and then output to a second transformer T2, the voltage is regulated through a second transformer T2, then a stimulation signal is output to a sublingual stimulation electrode, and the chin-tongue muscle of a wearer is stimulated to shrink through the sublingual stimulation electrode.
Referring to fig. 7, the stimulation pulse adjusting circuit includes a dual-channel operational amplifier LM258 and a third transistor Q3, a non-inverting input pin INB-of the dual-channel operational amplifier LM258 is connected to a PWM1 pin of the CPU controller through an RC filter, a non-inverting output pin OUTB of the dual-channel operational amplifier LM258 is connected to another non-inverting input pin INA-thereof, another output pin OUTA of the dual-channel operational amplifier LM258 is connected to a base of the third transistor Q3 through a resistor R11, a collector of the third transistor Q3 is connected to +12V, and an emitter of the third transistor Q3 is connected to + 9V.
Referring to fig. 8, the power circuit includes a power chip LM2596-5, and the power chip LM2596-5 converts a 12V voltage into a 5V voltage.
The respiratory state monitoring device provided by the embodiment further comprises a display screen 5 and a storage module, wherein the display screen and the storage module are respectively connected with the CPU controller; the display screen 5 is used for displaying data such as blood oxygen saturation, heart rate, respiratory pressure, respiratory temperature and the like; and the storage module is used for storing the measured data, so that statistical analysis is facilitated.
In the embodiment, the mask body 1 is symmetrically provided with two mask fixing buckles, and a fixing band is connected between the two mask fixing buckles, so that a user can wear the mask body firmly; the mask body 1 is also provided with an air suction port 7, the air suction port is provided with a one-way film, and the film is opened during air suction; still be provided with the pressure valve on the face guard body 1 for control respiratory pressure guarantees that the pharyngeal airway is open.
When the breathing mask with the hypoglossal nerve and diaphragm stimulation function provided by the embodiment is used, the exhaled airflow of a wearer is transmitted into the respiratory state monitoring device through the thin tube 2 connected with the mask body 1, the respiratory pressure detection circuit detects the pressure change of the respiratory airflow, the respiratory temperature detection circuit detects the temperature of the respiratory airflow, the oxyhemoglobin saturation detection circuit detects the oxyhemoglobin saturation of the wearer, and the heart rate detection circuit detects the heart rate of the wearer; when the CPU detects that the respiratory pressure and the respiratory temperature are unchanged, the respiration is determined to be apnea, the stimulation pulse current is controlled to generate a hypoglossal nerve stimulation pulse signal, the hypoglossal nerve is stimulated through a hypoglossal nerve electrode to cause the genioglossus muscle to contract, and the smoothness of a respiratory tract is ensured; when the blood oxygen saturation and the heart rate are reduced and the hypoglossal nerve stimulation is invalid, judging central apnea, controlling stimulation pulse current to generate a diaphragm stimulation pulse signal, and stimulating the diaphragm to contract through a diaphragm stimulation electrode; the stimulation electrodes do not produce stimulation during normal patient breathing.
Example two
The present embodiment provides a ventilation therapy device, which includes a main machine for generating therapeutic gas and a breathing mask communicated with an air outlet of the main machine, wherein the breathing mask is the breathing mask described in the above embodiment.
Wherein the ventilation therapy device may be a ventilator.
Although the present disclosure has been described with reference to specific embodiments, it should be understood that the scope of the present disclosure is not limited thereto, and those skilled in the art will appreciate that various modifications and changes can be made without departing from the spirit and scope of the present disclosure.
Claims (10)
1. A respiratory mask with hypoglossal nerve and diaphragm muscle stimulation functions is characterized by comprising a mask body, a respiratory state monitoring device arranged at the bottom of the mask body, and a hypoglossal stimulation electrode and a diaphragm muscle stimulation electrode which are connected with the respiratory state monitoring device, wherein the mask body is communicated with the respiratory state monitoring device through a thin tube;
the respiratory state monitoring device comprises a protective shell, a sensor detection circuit arranged in the protective shell, a CPU controller and a stimulation pulse circuit; the sensor detection circuit detects pressure, temperature, blood oxygen saturation and heart rate data of the wearer respiratory airflow introduced into the protective shell and transmits the data to the CPU controller;
the CPU controller judges whether the detected temperature and pressure of the breathing airflow of the wearer change in a set time period, if not, the CPU controller judges that the wearer has obstructive apnea, controls the stimulation pulse circuit to generate a sublingual stimulation pulse signal and transmits the sublingual stimulation pulse signal to the sublingual stimulation electrode, and stimulates the sublingual nerve to contract the genioglossus muscle through the sublingual stimulation electrode; simultaneously, judge whether the oxyhemoglobin saturation and the heart rate of the person of wearing are less than the setting value, if the oxyhemoglobin saturation and the heart rate of the person of wearing are less than the setting value to the temperature and the pressure of the breathing air current of the person of wearing are still when unchanging in the time quantum of setting for, judge that the person of wearing takes place central breathing pause, control stimulation pulse circuit and produce the diaphragm and stimulate pulse signal and transmit to diaphragm and stimulate electrode, stimulate the diaphragm through diaphragm and stimulate electrode and shrink.
2. The respiratory mask with hypoglossal nerve and diaphragm stimulation function as claimed in claim 1, wherein the respiratory pressure detection circuit comprises a pressure sensor, a first amplifier, a second amplifier, a third amplifier and a fourth amplifier, one input end of the pressure sensor is connected with an input end of the third amplifier, the other input end of the pressure sensor is connected with an output end of the third amplifier, two output ends of the pressure sensor are respectively connected with positive phase input ends of the first amplifier and the second amplifier, output ends of the first amplifier and the second amplifier are respectively connected with an input end of the fourth amplifier through a resistor, and an output end of the fourth amplifier is connected with the CPU controller.
3. The respiratory mask with hypoglossal nerve and diaphragm stimulation function of claim 1, wherein the respiratory temperature monitoring circuit comprises a temperature sensor, a fifth amplifier, a sixth amplifier, a seventh amplifier, an eighth amplifier and a steady state trigger;
the output end of the temperature sensor sequentially passes through a fifth amplifier, a sixth amplifier and a seventh amplifier which are connected in parallel and is connected with the positive input end of an eighth amplifier, the negative input end of the eighth amplifier is also connected with the output end of the temperature sensor, the output end of the eighth amplifier is connected with the input end of a steady trigger, and the output end of the steady trigger is connected with a CPU controller.
4. The respiratory mask with hypoglossal nerve and diaphragm stimulation function as claimed in claim 1, wherein the blood oxygen heart rate detection circuit comprises a heart rate blood oxygen sensor, and an output end of the heart rate blood oxygen sensor is connected with the CPU controller for detecting the blood oxygen saturation and the heart rate of the wearer and transmitting the blood oxygen saturation and the heart rate to the CPU controller.
5. The respiratory mask with hypoglossal nerve and diaphragm stimulation function as claimed in claim 1, wherein the stimulation pulse circuit comprises a stimulation pulse generation circuit and a stimulation pulse adjustment circuit;
the stimulation pulse generating circuit comprises a sublingual stimulation pulse generating circuit and a diaphragmatic muscle stimulation pulse generating circuit, wherein the input end of the sublingual stimulation pulse generating circuit is connected with the CPU controller, and the output end of the sublingual stimulation pulse generating circuit is connected with a sublingual stimulation electrode, and is used for receiving a control instruction output by the CPU controller, generating a sublingual stimulation pulse signal and outputting the sublingual stimulation pulse signal to the sublingual stimulation electrode; the input end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the CPU controller, and the output end of the diaphragmatic muscle stimulation pulse generation circuit is connected with the diaphragmatic muscle stimulation electrode and is used for receiving a control instruction output by the CPU controller, generating a diaphragmatic muscle stimulation pulse signal and outputting the diaphragmatic muscle stimulation pulse signal to the diaphragmatic muscle stimulation electrode; the stimulation pulse adjusting circuit is connected with a pulse width modulation interface of the CPU controller, so that the sublingual stimulation pulse signal and the diaphragm stimulation pulse signal intensity can be adjusted.
6. The respiratory mask as claimed in claim 5, wherein the stimulation pulse circuit further comprises a power circuit, and the power circuit is connected to the stimulation pulse generating circuit for providing the stimulation pulse generating circuit with required power.
7. The respiratory mask with hypoglossal nerve and diaphragm stimulation function as claimed in claim 5, wherein the diaphragm stimulation pulse generating circuit comprises a first triode and a first transformer, wherein a base of the first triode is connected with the CPU controller through a resistor, a collector of the first triode is connected with one end of a primary coil of the first transformer through a diode and a resistor, the collector of the first triode is also directly connected with the other end of the primary coil of the first transformer, and a secondary coil of the first transformer is connected with the diaphragm stimulation electrode.
8. The respiratory mask with hypoglossal nerve and diaphragm stimulation function as claimed in claim 5, wherein the hypoglossal stimulation pulse generating circuit comprises a second triode and a second transformer, a base of the second triode is connected with the CPU controller through a resistor, a collector of the second triode is connected with one end of a primary coil of the second transformer through a diode and a resistor, and a secondary coil of the second transformer is connected with the hypoglossal stimulation electrode.
9. The respiratory mask with the hypoglossal nerve and diaphragm stimulation function as claimed in claim 1, wherein the stimulation pulse adjusting circuit comprises a two-way operational amplifier and a third triode, a positive phase input end of the two-way operational amplifier is connected with the CPU controller through an RC filter, a positive phase output end of the two-way operational amplifier is connected with another positive phase input end of the two-way operational amplifier, and another output end of the two-way operational amplifier is connected with the third triode through a resistor.
10. A ventilation therapy device comprising a main unit for generating therapeutic gas and a respiratory mask as claimed in any one of claims 1 to 9 in communication with an outlet port of said main unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910784145.8A CN110585546A (en) | 2019-08-23 | 2019-08-23 | Respiratory mask with hypoglossal nerve and diaphragm muscle stimulation function and ventilation treatment equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910784145.8A CN110585546A (en) | 2019-08-23 | 2019-08-23 | Respiratory mask with hypoglossal nerve and diaphragm muscle stimulation function and ventilation treatment equipment |
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| Publication Number | Publication Date |
|---|---|
| CN110585546A true CN110585546A (en) | 2019-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910784145.8A Pending CN110585546A (en) | 2019-08-23 | 2019-08-23 | Respiratory mask with hypoglossal nerve and diaphragm muscle stimulation function and ventilation treatment equipment |
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| Country | Link |
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| CN (1) | CN110585546A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112842265A (en) * | 2020-12-31 | 2021-05-28 | 熙年科技(深圳)有限公司 | Protective mask capable of monitoring and treating human respiratory health |
| CN113040714A (en) * | 2021-03-09 | 2021-06-29 | 深圳市科瑞康实业有限公司 | Apnea monitoring and percutaneous electrical stimulation method and device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409646A (en) * | 1999-12-16 | 2003-04-09 | 电脑医师睡眠股份有限公司 | Bio-mask with integral sensors |
| CN1466435A (en) * | 2000-08-25 | 2004-01-07 | ���·��˹�������� | System for physiological monitoring during sleep |
| CN203468609U (en) * | 2013-06-18 | 2014-03-12 | 陈家良 | Monitoring and curing system for sleep apnea syndrome |
| US20150273166A1 (en) * | 2014-03-28 | 2015-10-01 | Weinmann Geraete Fuer Medizin Gmbh & Co. Kg | Method and device for therapy of periodic respiration |
| CN107789714A (en) * | 2017-10-26 | 2018-03-13 | 山东大学齐鲁医院 | A kind of multi-functional exhaled positive pressure nasal mask |
-
2019
- 2019-08-23 CN CN201910784145.8A patent/CN110585546A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1409646A (en) * | 1999-12-16 | 2003-04-09 | 电脑医师睡眠股份有限公司 | Bio-mask with integral sensors |
| CN1466435A (en) * | 2000-08-25 | 2004-01-07 | ���·��˹�������� | System for physiological monitoring during sleep |
| CN203468609U (en) * | 2013-06-18 | 2014-03-12 | 陈家良 | Monitoring and curing system for sleep apnea syndrome |
| US20150273166A1 (en) * | 2014-03-28 | 2015-10-01 | Weinmann Geraete Fuer Medizin Gmbh & Co. Kg | Method and device for therapy of periodic respiration |
| CN107789714A (en) * | 2017-10-26 | 2018-03-13 | 山东大学齐鲁医院 | A kind of multi-functional exhaled positive pressure nasal mask |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112842265A (en) * | 2020-12-31 | 2021-05-28 | 熙年科技(深圳)有限公司 | Protective mask capable of monitoring and treating human respiratory health |
| CN113040714A (en) * | 2021-03-09 | 2021-06-29 | 深圳市科瑞康实业有限公司 | Apnea monitoring and percutaneous electrical stimulation method and device |
| CN113040714B (en) * | 2021-03-09 | 2023-05-02 | 深圳市科瑞康实业有限公司 | Method and device for monitoring apnea and transdermally electrically stimulating |
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