CN110584708A - Portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation - Google Patents
Portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/04—Measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/56—Details of data transmission or power supply
- A61B8/565—Details of data transmission or power supply involving data transmission via a network
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
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Abstract
The invention belongs to the technical field of ultrasonic intelligent diagnosis and regulation, and particularly relates to a portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation, which comprises a flexible ultrasonic sensor, an ultrasonic earphone, an ultrasonic pulse device, an ultrasonic intelligent control and communication mobile phone terminal, wherein the flexible ultrasonic sensor is connected with the ultrasonic earphone; the flexible ultrasonic sensor is used for positioning blood vessels of a monitored person and monitoring blood pressure, and the ultrasonic earphone is used for stimulating vagus nerves of ears to regulate blood pressure; the ultrasonic intelligent control and communication mobile phone terminal is used for controlling the output of an electric pulse signal of the ultrasonic sensor pulse device, combines flexible ultrasonic sensing, ultrasonic nerve stimulation and intelligent mobile phone monitoring, and realizes real-time monitoring and effective regulation and control of human body blood pressure under the condition of satisfying the freedom of movement of a monitored person.
Description
Technical Field
The invention belongs to the technical field of ultrasonic intelligent diagnosis and regulation, and particularly relates to a portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation.
Background
Blood pressure is the lateral pressure (i.e., pressure) acting on the arterial wall per unit area as blood flows through a blood vessel, which is the driving force for propelling blood flow through the blood vessel. Normal human blood pressure has high and low value periods during the day, but if blood pressure is maintained in the high value phase for a long period of time, i.e., high blood pressure, it damages the heart of the human and causes many health problems. According to the recent report of lancets in 2017, the number of global hypertensive patients is estimated to reach 11 hundred million, and more than half of hypertensive patients live in Asia, wherein China accounts for 2.26 hundred million.
Hypertension is a major cause of coronary heart disease and stroke. In addition, heart failure, peripheral vascular disease, renal function impairment, retinal hemorrhage, visual impairment, and the like may also be caused. According to the World Health Organization (WHO), the related diseases caused by hypertension cause about 750 million deaths per year worldwide, accounting for 12.8% of the total deaths worldwide. Thus, hypertension is known as "invisible killer" of human health.
Blood pressure measurement is a prerequisite for prevention and control of hypertension, and blood pressure regulation is a fundamental means for solving the problem of hypertension.
In the aspect of blood pressure monitoring, the current non-invasive blood pressure electronic monitoring equipment can be used for continuously monitoring waveforms of arterial and venous blood pressure in real time, but a pressure sensor for monitoring the blood pressure cannot actively adapt to the soft and easily-deformable characteristics of the skin surface, so that the pressure sensor cannot be used for monitoring blood pressure information under the condition of human body activity, and cannot realize the function of regulating and controlling the blood pressure of the human body;
in the aspect of blood pressure regulation, the current wearable electronic equipment realizes blood pressure balance by utilizing a current nerve stimulation mode mainly based on the regulation function of a nervous system on blood pressure, but the target property of the target nerve is low due to the dispersive nature of the current, potential safety hazards exist, and regulation and control cannot be performed under the real-time monitoring of the blood pressure.
Therefore, there is a need for a wearable electronic device that can integrate blood pressure monitoring and blood pressure regulation to realize real-time monitoring and effective regulation of blood pressure.
Disclosure of Invention
Technical problem to be solved
Aiming at the existing technical problems, the invention provides a portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation, which combines flexible ultrasonic sensing, ultrasonic nerve stimulation and smart phone monitoring and realizes real-time monitoring and effective regulation and control of human blood pressure under the condition of satisfying the free movement of a monitored person.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that: a portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation comprises a flexible ultrasonic sensor 1, an ultrasonic earphone 2, an ultrasonic pulse device 3 and an ultrasonic intelligent control and communication mobile phone terminal 4;
the flexible ultrasonic sensor is used for positioning the blood vessel of a monitored person, acquiring blood vessel diameter change data in real time by using ultrasonic waves transmitted and received by the flexible ultrasonic sensor, and transmitting the acquired blood vessel diameter change data to the ultrasonic pulse device;
the ultrasonic pulse device is used for receiving the blood vessel diameter change data sent by the flexible ultrasonic sensor, converting the data into digital analog signal information and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal;
the ultrasonic intelligent control and communication mobile phone terminal is used for receiving digital analog signal information sent by the ultrasonic pulse device and feeding back the digital analog signal to the ultrasonic pulse device;
the ultrasonic pulse device is also used for receiving an instruction sent by the ultrasonic intelligent control and communication mobile phone terminal according to a digital analog signal and sending the instruction to the ultrasonic earphone;
the ultrasonic earphone is used for receiving the instruction sent by the ultrasonic pulse device, sending ultrasonic waves according to the instruction and stimulating the vagus nerve of the ear to regulate the blood pressure.
Further, the flexible ultrasonic sensor includes: flexible electrodes, ultrasonic pressure sensors and flexible electronic skin;
the flexible electrode is used for connecting the ultrasonic pressure sensor with the ultrasonic pulse device;
the ultrasonic pressure sensor is used for sending out ultrasonic waves and receiving ultrasonic echoes, accurately positioning the blood vessel of a monitored person and recording the diameter change of the blood vessel in real time;
the ultrasonic pressure sensor is also used for carrying out reversible conversion on the ultrasonic and electric pulse signals;
the flexible electronic skin is adapted to contact the skin surface and conform thereto by actively adapting to the soft and deformable nature of the skin surface.
Further, the ultrasonic pulse device comprises an ultrasonic sensor pulse device and an ultrasonic earphone pulse device;
the ultrasonic sensor pulse device is used for generating an electric pulse signal, driving the flexible ultrasonic sensor to emit ultrasonic waves, receiving the electric pulse signal fed back by the flexible ultrasonic sensor, converting the electric pulse signal into a digital analog signal, and sending the digital analog signal to an ultrasonic intelligent control and communication mobile phone terminal, and the ultrasonic sensor pulse device is connected with the flexible ultrasonic sensor through a wire;
the ultrasonic earphone pulse device is used for generating an electric pulse signal and driving the ultrasonic earphone to send ultrasonic waves to adjust the blood pressure, and the ultrasonic earphone pulse device is connected with the ultrasonic earphone through wireless Bluetooth or wired connection.
Further, the ultrasonic sensor pulse device comprises a first pulse generator and a pulse receiver;
the first pulse generator comprises an arbitrary waveform generator, a power amplifier, an impedance matcher and a switch selector, and is used for outputting electric pulse signals with different intensities, frequencies and/or modes by receiving instructions of the ultrasonic intelligent control and communication mobile phone terminal, exciting the flexible ultrasonic sensor to vibrate according to corresponding working frequency and transmitting ultrasonic waves according to set pulse repetition frequency;
the pulse receiver comprises an amplifying circuit, a filtering circuit, an automatic control gain circuit and a signal feedback device, and is used for receiving an electric pulse signal fed back by the flexible ultrasonic sensor, converting the electric pulse signal into a digital analog signal and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal.
Furthermore, the ultrasonic earphone pulse device comprises a second pulse generator, wherein the second pulse generator comprises an arbitrary waveform generator, a power amplifier, an impedance matcher and a switch selector, and is used for outputting electric pulse signals with different intensities, frequencies and/or modes by receiving instructions of the ultrasonic intelligent control and communication mobile phone terminal, so as to excite the ultrasonic earphone to vibrate according to corresponding working frequency and transmit ultrasonic waves according to a set pulse repetition frequency.
Further, the system also comprises a cloud server and a doctor client;
the ultrasonic intelligent control and communication mobile phone terminal is also used for sending blood pressure information to the cloud server;
the cloud server is used for receiving the blood pressure information, combining the blood pressure information with a big data center obtained in advance, diagnosing and analyzing the blood pressure change condition of the monitored person and feeding the blood pressure change condition back to the doctor client in real time;
the ultrasonic intelligent control and communication mobile phone terminal is connected with the cloud server through wifi or 3G/4G/5G;
the doctor client is connected with the cloud server through wifi or 3G/4G/5G.
Further, the ultrasonic intelligent control and communication mobile phone terminal comprises an ultrasonic intelligent control mobile phone terminal and an ultrasonic intelligent communication mobile phone terminal;
the ultrasonic intelligent control mobile phone terminal comprises an ultrasonic blood pressure monitoring control module and an ultrasonic blood pressure stimulation control module;
the ultrasonic blood pressure monitoring control module is used for sending an instruction for controlling the first pulse signal generator, receiving a digital analog signal fed back by the pulse receiving device, simulating real-time blood pressure change data by the digital analog signal based on the relation between the diameter of the blood vessel and the blood pressure to obtain blood pressure information, and feeding the blood pressure information back to the ultrasonic blood pressure stimulation control module, wherein the ultrasonic blood pressure monitoring control module is wirelessly connected or wired connected with the ultrasonic sensor pulse device through Bluetooth;
the ultrasonic blood pressure stimulation control module is used for receiving the blood pressure information, comparing the blood pressure information fed back by the ultrasonic blood pressure monitoring control module with the normal blood pressure information obtained in advance, evaluating the health condition of the blood pressure, and controlling the output type and the intensity of an electric pulse signal of the second pulse generator in a feedback manner, so as to adjust the ultrasonic output of the ultrasonic earphone and stimulate the vagus nerve of the ear, and the ultrasonic blood pressure stimulation control module is connected with the ultrasonic earphone in a wireless manner or in a wired manner through Bluetooth;
the ultrasonic intelligent communication mobile phone terminal is used for storing blood pressure information and regulation and control data of a monitored person and storing the blood pressure information and the regulation and control data to the cloud server through the mobile phone terminal;
the regulation and control data comprises instructions sent by the ultrasonic blood pressure stimulation control module and fed back to the second pulse generator, and the second pulse generator further controls the ultrasonic earphone to send ultrasonic waves to stimulate the vagus nerve of the ear to regulate the data information of the blood pressure.
Further, flexible ultrasonic sensor with ultrasonic sensor pulse device is integrated into intelligent bracelet, and through wireless bluetooth mode with supersound intelligent control is connected with communication mobile phone terminal.
Furthermore, the ultrasonic intelligent control and communication mobile phone terminal and the ultrasonic pulse device are integrated into a whole and are connected with the flexible ultrasonic sensor in a wired mode.
(III) advantageous effects
The invention has the beneficial effects that: the blood vessel of a monitored person is positioned through the flexible ultrasonic sensor, an electric pulse signal generated by an ultrasonic sensor pulse device connected with the flexible ultrasonic sensor in a wired mode is used for driving the flexible ultrasonic sensor to emit ultrasonic waves, meanwhile, the electric pulse signal fed back by the flexible ultrasonic sensor is received and converted into a digital analog signal, and the digital analog signal is transmitted to an ultrasonic intelligent control and communication mobile phone terminal through a Bluetooth wireless mode or a wired connection; then the ultrasonic intelligent control and communication mobile phone terminal simulates the received feedback signal to real-time blood pressure change data, feedback controls the output type and the intensity of an electric pulse signal of the ultrasonic earphone pulse device, and further controls the ultrasonic earphone to send out low-intensity ultrasonic waves in a Bluetooth wireless connection mode and a wired connection mode to realize blood pressure regulation; the invention combines a flexible ultrasonic sensor, an ultrasonic earphone, an ultrasonic pulse device and an ultrasonic intelligent control and communication mobile phone terminal, realizes real-time monitoring and effective regulation and control of blood pressure of each important blood vessel part of a human body under the condition of satisfying the free movement of a monitored person, and is noninvasive blood pressure intelligent monitoring and regulation and control equipment integrating free type, portability and intelligence.
Drawings
FIG. 1 is a block diagram of the basic structure of a portable intelligent ultrasound blood pressure monitoring system based on ear vagus nerve stimulation according to the present invention;
FIG. 2 is a schematic structural diagram of an embodiment of a portable intelligent ultrasound blood pressure monitoring system based on ear vagus nerve stimulation according to the present invention;
fig. 3 is a schematic structural diagram of another embodiment of the portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation according to the present invention.
In the figure: 1. a flexible ultrasonic sensor; 11. a flexible electrode; 12. an ultrasonic pressure sensor; 13. a flexible electronic skin; 2. an ultrasonic earphone; 3. an ultrasonic pulse device; 31. an ultrasonic sensor pulse device; 311. a first pulse generator; 312. a pulse receiver; 32. an ultrasonic earphone pulse device; 321. a second pulse generator; 4. an ultrasonic intelligent control and communication mobile phone terminal; 41. the mobile phone terminal is intelligently controlled by ultrasonic; 411. an ultrasonic blood pressure monitoring control module; 412. an ultrasonic blood pressure stimulation control module; 42. an ultrasonic intelligent communication mobile phone terminal; 5. a cloud server; 6. a doctor client.
Detailed Description
For the purpose of better explaining the present invention and to facilitate understanding, the present invention will be described in detail by way of specific embodiments with reference to the accompanying drawings.
As shown in fig. 1, a portable intelligent ultrasound blood pressure monitoring system based on ear vagus nerve stimulation comprises a flexible ultrasound sensor 1, an ultrasound earphone 2, an ultrasound pulse device 3, an ultrasound intelligent control and communication mobile phone terminal 4; the ultrasonic wave has the characteristics of good directivity, strong penetrating power, energy transmission and the like, the fluctuation form of the ultrasonic wave is widely used for detection and diagnosis (such as B ultrasonic), and the energy form of the ultrasonic wave can also be used for targeted therapy (such as brain essential tremor). The characteristics of the ultrasonic wave are beneficial to integrating blood pressure monitoring and nerve stimulation blood pressure regulation. However, a portable intelligent ultrasonic blood pressure monitoring system integrating blood pressure monitoring and nerve stimulation blood pressure regulation is still lacking at present;
the flexible ultrasonic sensor 1 is used for positioning a blood vessel of a monitored person, acquiring blood vessel diameter change data in real time by using ultrasonic waves transmitted and received by the flexible ultrasonic sensor, and transmitting the acquired blood vessel diameter change data to the ultrasonic pulse device 3;
the ultrasonic pulse device 3 is used for receiving the blood vessel diameter change data sent by the flexible ultrasonic sensor 1, converting the data into digital analog signal information and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal 4;
the ultrasonic intelligent control and communication mobile phone terminal 4 is used for receiving digital analog signal information sent by the ultrasonic pulse device 3 and feeding back the digital analog signal to the ultrasonic pulse device 3;
the ultrasonic pulse device 3 is also used for receiving an instruction sent by the ultrasonic intelligent control and communication mobile phone terminal 4 according to a digital analog signal and sending the instruction to the ultrasonic earphone 2;
the ultrasonic earphone 2 is used for receiving the instruction sent by the ultrasonic pulse device 3, sending ultrasonic waves according to the instruction and stimulating the vagus nerve of the ear to regulate the blood pressure.
The working principle of the technical scheme of the invention is as follows: the blood vessel of a monitored person is positioned by the flexible ultrasonic sensor 1, the ultrasonic intelligent control and communication mobile phone terminal 4 outputs an electric pulse signal for controlling the ultrasonic sensor pulse device 31, then the electric pulse signal generated by the ultrasonic sensor pulse device 31 drives the flexible ultrasonic sensor 1 to emit ultrasonic waves, meanwhile, the ultrasonic sensor pulse device 31 receives the electric pulse signal fed back by the flexible ultrasonic sensor 1 and converts the electric pulse signal into a digital analog signal, the digital analog signal is connected with the ultrasonic intelligent control and communication mobile phone terminal 4 in a Bluetooth wireless mode or in a wired mode, then the ultrasonic intelligent control and communication mobile phone terminal 4 simulates the received feedback signal to real-time blood pressure change data and controls the output type and the intensity of the electric pulse signal of the ultrasonic earphone pulse device 32 in a feedback mode, and then the ultrasonic earphone 2 is controlled to emit low-intensity ultrasonic waves in a Bluetooth wireless connection mode and in a wired connection mode to realize blood pressure regulation, the flexible ultrasonic sensor 1, the ultrasonic earphone 2, the ultrasonic pulse device 3 and the ultrasonic intelligent control and communication mobile phone terminal 4 are combined, so that the real-time monitoring and the effective regulation and control of the blood pressure of each important blood vessel part of a human body are realized under the condition of satisfying the freedom of the movement of a monitored person, and the device is a noninvasive blood pressure intelligent monitoring and regulating and controlling device integrating freedom, portability and intelligence.
The flexible ultrasonic sensor 1 includes: a flexible electrode 11, an ultrasonic pressure sensor 12 and a flexible electronic skin 13; the flexible electrode 11 is mainly a mesh metal electrode and is used for guaranteeing the performance stability of the flexible ultrasonic sensor 1 and realizing the effective connection of the pressure sensor and the electric pulse device; the ultrasonic pressure sensor 12 is mainly made of piezoelectric material and is used for sending out ultrasonic waves and receiving ultrasonic echoes, accurately positioning the blood vessel of a monitored person, realizing reversible conversion of ultrasonic waves and electric pulse signals and recording the diameter change of the blood vessel in real time; the flexible electronic skin 13 is mainly silicone, and through the soft and yielding characteristic of active adaptation skin surface to keep conformal with it, can freely attach in arbitrary blood vessel position of monitored person on the one hand, even cause the skin surface to take place under the great deformation (30%) circumstances at the motion, also can well attach, do not influence the freedom of motion of monitored person, on the other hand reduces the energy loss of interface department ultrasonic wave, promotes the recovery of ultrasonic wave, improves blood pressure monitoring precision.
The ultrasonic pulse device 3 comprises an ultrasonic sensor pulse device 31 and an ultrasonic earphone pulse device 32;
the ultrasonic sensor pulse device 31 is used for generating an electric pulse signal and driving the flexible ultrasonic sensor 1 to emit ultrasonic waves, and is also used for receiving the electric pulse signal fed back by the flexible ultrasonic sensor 1 and converting the electric pulse signal into a digital analog signal, and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal 4, and the ultrasonic sensor pulse device 31 is connected with the flexible ultrasonic sensor 1 through a wire;
the ultrasonic earphone pulse device 32 is used for generating an electric pulse signal and driving the ultrasonic earphone 2 to send out ultrasonic waves to adjust the blood pressure, and the ultrasonic earphone pulse device 32 is connected with the ultrasonic earphone 2 through wireless Bluetooth or wired connection.
The ultrasonic sensor pulse device 31 includes a first pulse generator 311 and a pulse receiver 312; the first pulse generator 311 includes an arbitrary waveform generator, a power amplifier, an impedance matcher, and a switch selector, and is configured to output electric pulse signals of different intensities, frequencies, and/or modes by receiving an instruction of the ultrasonic intelligent control and the communication handset terminal 4, to excite the flexible ultrasonic sensor 1 to vibrate at a corresponding working frequency and transmit ultrasonic waves at a set pulse repetition frequency; the pulse receiver 312, which includes an amplifying circuit, a filtering circuit, an automatic control gain circuit, a signal feedback device, etc., is used to receive the electric pulse signal fed back by the flexible ultrasonic sensor 1, and convert the electric pulse signal into a digital analog signal to be sent to the ultrasonic intelligent control and communication mobile phone terminal 4.
The ultrasonic earphone pulse device 32 comprises a second pulse generator 321, wherein the second pulse generator 321 comprises an arbitrary waveform generator, a power amplifier, an impedance matcher and a switch selector, and is used for outputting electric pulse signals with different intensities, frequencies and/or modes by receiving instructions of ultrasonic intelligent control and the communication mobile phone terminal 4, exciting the ultrasonic earphone 2 to vibrate according to corresponding working frequency and transmitting ultrasonic waves according to set pulse repetition frequency.
The system also comprises a cloud server 5 and a doctor client 6; the ultrasonic intelligent control and communication mobile phone terminal 4 is also used for sending the blood pressure information to the cloud server 5; the cloud server 5 is used for receiving the blood pressure information, combining the blood pressure information with a big data center obtained in advance, diagnosing and analyzing the blood pressure change condition of the monitored person and feeding the blood pressure change condition back to the doctor client 6 in real time; the ultrasonic intelligent control and communication mobile phone terminal 4 is connected with the cloud server 5 through wifi or 3G/4G/5G; the cloud server 5 is combined with a relevant big data center to diagnose and analyze the blood pressure change condition of the monitored person and feed back the blood pressure change condition in real time; if the blood pressure still exceeds the normal blood pressure range after ultrasonic stimulation, the cloud server 5 contacts nearby doctors through the doctor client 6 in time, the doctors give treatment schemes or adjust and modify the original schemes according to the conditions of monitored persons, and the doctor client 6 is connected with the cloud server 5 through wifi or 3G/4G/5G.
The ultrasonic intelligent control and communication mobile phone terminal 4 comprises an ultrasonic intelligent control mobile phone terminal 41 and an ultrasonic intelligent communication mobile phone terminal 42; the ultrasonic intelligent control mobile phone terminal 41 comprises an ultrasonic blood pressure monitoring control module 411 and an ultrasonic blood pressure stimulation control module 412;
the ultrasonic blood pressure monitoring control module 411 is configured to send an instruction for controlling the first pulse signal generator 311, receive a digital analog signal fed back by the pulse receiving device 312, simulate real-time blood pressure change data based on a relationship between a blood vessel diameter and blood pressure by the digital analog signal to obtain blood pressure information, and feed the blood pressure information back to the ultrasonic blood pressure stimulation control module 412; the ultrasonic blood pressure monitoring control module 411 is wirelessly connected or wired with the ultrasonic sensor pulse device 31 through Bluetooth;
the ultrasonic blood pressure stimulation control module 412 is configured to receive blood pressure information, compare the blood pressure information fed back by the ultrasonic blood pressure monitoring control module 411 with pre-obtained normal blood pressure information, evaluate the health condition of blood pressure, and control the output type and intensity of the electrical pulse signal of the second pulse generator 321 through feedback, so as to adjust the ultrasonic output of the ultrasonic earphone 2 and stimulate the vagus nerve of the ear; the ultrasonic blood pressure stimulation control module 412 is wirelessly connected or wired with the ultrasonic earphone 2 through Bluetooth; the ultrasonic intelligent communication mobile phone terminal 42 is used for storing the blood pressure information and the regulation and control data of the monitored person and storing the blood pressure information and the regulation and control data to the cloud server 5 through the mobile phone terminal; the regulation and control data includes instructions sent by the ultrasound blood pressure stimulation control module 412 and fed back to the second pulse generator 321, and the second pulse generator 321 further controls the ultrasound earphone 2 to send out ultrasonic waves, stimulate the vagus nerve of the ear to regulate the data information of the blood pressure, and stimulate the vagus nerve of the ear to maintain the normal stability of the blood pressure.
Example 1
As shown in fig. 2, the flexible ultrasonic sensor 1 and the ultrasonic sensor pulse device 31 can be integrated into an intelligent bracelet, and are connected with the ultrasonic intelligent control and communication mobile phone terminal 4 in a wireless bluetooth manner, the blood vessel of a monitored person is positioned by the flexible ultrasonic sensor 1, then the ultrasonic intelligent control and communication mobile phone terminal 4 outputs an electric pulse signal for controlling the ultrasonic sensor pulse device 31, then the electric pulse signal generated by the ultrasonic sensor pulse device 31 drives the flexible ultrasonic sensor 1 to emit ultrasonic waves, meanwhile, the ultrasonic sensor pulse device 31 receives the electric pulse signal fed back by the flexible ultrasonic sensor 1 and converts the electric pulse signal into a digital analog signal, the digital analog signal is connected with the ultrasonic intelligent control and communication mobile phone terminal 4 in a bluetooth wireless manner, and then the ultrasonic intelligent control and communication mobile phone terminal 4 simulates the received feedback signal to obtain real-time blood pressure change data to feedback control the ultrasonic earphone pulse device 32 electric pulse signal's output type and intensity, and then adjust and send low-intensity ultrasonic wave through the supersound earphone 2 of being connected with supersound earphone pulser 32 bluetooth wireless connection mode and wired connection mode and be used for blood pressure control, combine together flexible ultrasonic sensor 1, supersound pulser 3 and supersound intelligent control and communication mobile phone terminal 4, realize realizing the real-time supervision and the effective regulation and control to each important vascular position blood pressure of human body under the condition that satisfies the free condition of the activity of monitored person, be one kind collect the free formula, portable and intelligent non-invasive blood pressure intelligent monitoring and regulation and control equipment as an organic whole.
Example 2
As shown in fig. 3, the ultrasonic intelligent control and communication handset terminal 4 and the ultrasonic impulse device 3 are integrated into a whole and connected with the flexible ultrasonic sensor 1 by a wired connection way, so as to realize real-time monitoring, diagnosis and analysis of blood pressure, the flexible ultrasonic sensor 1 positions blood vessels of a monitored person, then the ultrasonic intelligent control and communication handset terminal 4 outputs an electric pulse signal for controlling the ultrasonic impulse device 31, then the electric pulse signal generated by the ultrasonic impulse device 31 drives the flexible ultrasonic sensor 1 to emit ultrasonic waves, meanwhile, the ultrasonic impulse device 31 receives the electric pulse signal fed back by the flexible ultrasonic sensor 1 and converts the electric pulse signal into a digital analog signal, the digital analog signal is connected to the ultrasonic intelligent control and communication handset terminal 4 by a wired connection way, and then the ultrasonic intelligent control and communication handset terminal 4 simulates the received feedback signal to obtain real-time blood pressure change data and controls the ultrasonic ear feedback The output type and the intensity of the electrical pulse signal of the machine pulse device 32, and then adjust and send the low-intensity ultrasonic wave through the ultrasonic earphone 2 connected with the ultrasonic earphone pulse device 32 Bluetooth wireless connection mode and the wired connection mode and be used for blood pressure regulation, combine together flexible ultrasonic sensor 1, ultrasonic pulse device 3 and ultrasonic intelligent control and communication mobile phone terminal 4, realize the real-time monitoring and effective regulation and control to each important vascular position blood pressure of human body under the condition that satisfies the free activity of the monitored person, it is a collection free type, portable and intelligent non-invasive blood pressure intelligent monitoring and regulation and control equipment as an organic whole that becomes.
The technical principles of the present invention have been described above in connection with specific embodiments, which are intended to explain the principles of the present invention and should not be construed as limiting the scope of the present invention in any way. Based on the explanations herein, those skilled in the art will be able to conceive of other embodiments of the present invention without inventive efforts, which shall fall within the scope of the present invention.
Claims (9)
1. A portable intelligent ultrasonic blood pressure monitoring system based on ear vagus nerve stimulation is characterized by comprising a flexible ultrasonic sensor (1), an ultrasonic earphone (2), an ultrasonic pulse device (3) and an ultrasonic intelligent control and communication mobile phone terminal (4);
the flexible ultrasonic sensor (1) is used for positioning a blood vessel of a monitored person, acquiring blood vessel diameter change data in real time by using ultrasonic waves transmitted and received by the flexible ultrasonic sensor, and transmitting the acquired blood vessel diameter change data to the ultrasonic pulse device (3);
the ultrasonic pulse device (3) is used for receiving the blood vessel diameter change data sent by the flexible ultrasonic sensor (1), converting the data into digital analog signal information and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal (4);
the ultrasonic intelligent control and communication mobile phone terminal (4) is used for receiving digital analog signal information sent by the ultrasonic pulse device (3) and sending an instruction to the ultrasonic pulse device (3) by the digital analog signal;
the ultrasonic pulse device (3) is also used for receiving an instruction sent by the ultrasonic intelligent control and communication mobile phone terminal (4) according to a digital analog signal and sending the instruction to the ultrasonic earphone (2);
the ultrasonic earphone (2) is used for receiving the instruction sent by the ultrasonic pulse device (3), sending ultrasonic waves according to the instruction and stimulating the vagus nerve of the ear to regulate the blood pressure.
2. The portable intelligent ear vagus nerve stimulation based ultrasonic blood pressure monitoring system according to claim 1, wherein the flexible ultrasonic sensor (1) comprises: the ultrasonic pressure sensor comprises a flexible electrode (11), an ultrasonic pressure sensor (12) and a flexible electronic skin (13);
the flexible electrode (11) is used for connecting the ultrasonic pressure sensor (12) with the ultrasonic pulse device (3);
the ultrasonic pressure sensor (12) is used for sending out ultrasonic waves and receiving ultrasonic echoes, accurately positioning the blood vessel of a monitored person and recording the diameter change of the blood vessel in real time;
the ultrasonic pressure sensor (12) is also used for carrying out reversible conversion on ultrasonic and electric pulse signals;
the flexible electronic skin (13) is adapted to contact the skin surface and to conform thereto by actively adapting to the soft and deformable nature of the skin surface.
3. The portable intelligent ear vagus nerve stimulation based ultrasonic blood pressure monitoring system according to claim 2, wherein the ultrasonic impulse device (3) comprises an ultrasonic sensor impulse device (31) and an ultrasonic earphone impulse device (32);
the ultrasonic sensor pulse device (31) is used for generating an electric pulse signal, driving the flexible ultrasonic sensor (1) to emit ultrasonic waves, receiving the electric pulse signal fed back by the flexible ultrasonic sensor (1) and converting the electric pulse signal into a digital analog signal, and sending the digital analog signal to an ultrasonic intelligent control and communication mobile phone terminal (4), wherein the ultrasonic sensor pulse device (31) is in wired connection with the flexible ultrasonic sensor (1);
the ultrasonic earphone pulse device (32) is used for generating electric pulse signals and driving the ultrasonic earphone (2) to send ultrasonic waves to adjust blood pressure, and the ultrasonic earphone pulse device (32) is connected with the ultrasonic earphone (2) through wireless Bluetooth or wired connection.
4. The portable intelligent ear vagus nerve stimulation based ultrasound blood pressure monitoring system according to claim 3, wherein the ultrasound sensor pulse device (31) comprises a first pulse generator (311) and a pulse receiver (312);
the first pulse generator (311) comprises an arbitrary waveform generator, a power amplifier, an impedance matcher and a switch selector, and is used for outputting electric pulse signals with different intensities, frequencies and/or modes by receiving an instruction of the ultrasonic intelligent control and communication mobile phone terminal (4), exciting the flexible ultrasonic sensor (1) to vibrate according to a corresponding working frequency and transmitting ultrasonic waves according to a set pulse repetition frequency;
the pulse receiver (312) comprises an amplifying circuit, a filtering circuit, an automatic control gain circuit and a signal feedback device, and is used for receiving an electric pulse signal fed back by the flexible ultrasonic sensor (1), converting the electric pulse signal into a digital analog signal and sending the digital analog signal to the ultrasonic intelligent control and communication mobile phone terminal (4).
5. The portable intelligent ultrasonic blood pressure monitoring system based on the vagus nerve stimulation of ear as claimed in claim 3, wherein the ultrasonic earphone pulse device (32) comprises a second pulse generator (321), the second pulse generator (321) comprises an arbitrary waveform generator, a power amplifier, an impedance matcher, and a switch selector, and is used for exciting the ultrasonic earphone (2) to vibrate at the corresponding working frequency and transmitting ultrasonic waves at the set pulse repetition frequency by receiving the instructions of the ultrasonic intelligent control and communication handset terminal (4) and outputting electric pulse signals with different intensities, frequencies and/or modes.
6. The portable intelligent ear vagus nerve stimulation based ultrasound blood pressure monitoring system according to claim 1, further comprising a cloud server (5) and a doctor client (6);
the ultrasonic intelligent control and communication mobile phone terminal (4) is also used for sending blood pressure information to the cloud server (5);
the cloud server (5) is used for receiving the blood pressure information, combining the blood pressure information with a big data center obtained in advance, diagnosing and analyzing the blood pressure change condition of the monitored person and feeding the blood pressure change condition back to the doctor client (6) in real time;
the ultrasonic intelligent control and communication mobile phone terminal (4) is connected with the cloud server (5) through wifi or 3G/4G/5G;
the doctor client (6) is connected with the cloud server (5) through wifi or 3G/4G/5G.
7. The portable intelligent ultrasonic blood pressure monitoring system based on the auricular vagus nerve stimulation according to claim 4 or 5, wherein the ultrasonic intelligent control and communication mobile phone terminal (4) comprises an ultrasonic intelligent control mobile phone terminal (41) and an ultrasonic intelligent communication mobile phone terminal (42);
the ultrasonic intelligent control mobile phone terminal (41) comprises an ultrasonic blood pressure monitoring control module (411) and an ultrasonic blood pressure stimulation control module (412);
the ultrasonic blood pressure monitoring control module (411) is used for sending an instruction for controlling the first pulse signal generator (311), receiving a digital analog signal fed back by the pulse receiving device (312), simulating real-time blood pressure change data by the digital analog signal based on the relation between the diameter of a blood vessel and the blood pressure to obtain blood pressure information, and feeding the blood pressure information back to the ultrasonic blood pressure stimulation control module (412), wherein the ultrasonic blood pressure monitoring control module (411) is connected with the ultrasonic sensor pulse device (31) in a Bluetooth wireless mode or in a wired mode;
the ultrasonic blood pressure stimulation control module (412) is used for receiving the blood pressure information, comparing the blood pressure information fed back by the ultrasonic blood pressure monitoring control module (411) with the normal blood pressure information obtained in advance, evaluating the health condition of the blood pressure, and controlling the output type and the intensity of an electric pulse signal of the second pulse generator (321) in a feedback mode, so that the ultrasonic output of the ultrasonic earphone (2) is adjusted, the vagus nerve of the ear is stimulated, and the ultrasonic blood pressure stimulation control module (412) is wirelessly or in wired connection with the ultrasonic earphone (2) through Bluetooth;
the ultrasonic intelligent communication mobile phone terminal (42) is used for storing blood pressure information and regulation and control data of a monitored person and storing the blood pressure information and the regulation and control data to the cloud server (5) through the mobile phone terminal;
the regulation and control data comprises data information which is fed back to the second pulse generator (321) through an instruction sent by the ultrasonic blood pressure stimulation control module (412), and the second pulse generator (321) further controls the ultrasonic earphone (2) to send ultrasonic waves to stimulate the vagus nerve of the ear to regulate the blood pressure.
8. The portable intelligent ultrasonic blood pressure monitoring system based on the ear vagus nerve stimulation according to claim 3, wherein the flexible ultrasonic sensor (1) and the ultrasonic sensor pulse device (31) are integrated into an intelligent bracelet and connected with the ultrasonic intelligent control and communication mobile phone terminal (4) in a wireless Bluetooth mode.
9. The portable intelligent ultrasonic blood pressure monitoring system based on the ear vagus nerve stimulation according to claim 1, wherein the ultrasonic intelligent control and communication handset terminal (4) is integrated with the ultrasonic pulse device (3) and connected with the flexible ultrasonic sensor (1) in a wired manner.
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