CN110507406A - Cryoablation catheter and application thereof - Google Patents
Cryoablation catheter and application thereof Download PDFInfo
- Publication number
- CN110507406A CN110507406A CN201910810512.7A CN201910810512A CN110507406A CN 110507406 A CN110507406 A CN 110507406A CN 201910810512 A CN201910810512 A CN 201910810512A CN 110507406 A CN110507406 A CN 110507406A
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- cryoablation
- expandable members
- insulation
- area
- ablation areas
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- 208000027233 Vagus Nerve injury Diseases 0.000 claims description 7
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00541—Lung or bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
Abstract
The invention relates to a cryoablation catheter and application thereof, wherein the cryoablation catheter comprises an expandable member and a pipeline, wherein the expandable member is provided with a heat insulation area and an ablation area, and the pipeline comprises an air inlet pipeline and an air return pipeline which are respectively communicated with an inner chamber of the expandable member; the expandable component is provided with an expansion state and a contraction state, a freezing medium enters the expandable component from the air inlet pipeline to enable the expandable component to be in the expansion state, the cold quantity transmission of the freezing medium is isolated in the heat insulation area, the cold quantity transmission is realized in the ablation area for cryoablation, and the freezing medium flows back through the air return pipeline. The cryoablation catheter in the expanded state has a larger balloon body for sufficient cold heat exchange, so that the cryoinjury penetrates through the whole airway wall, and the cryoablation catheter is provided with an ablation and heat insulation area to reduce the injury of unnecessary tissues as much as possible.
Description
Technical field
The present invention relates to cryoablation technical field more particularly to a kind of cryoablation conduit and its applications.
Background technique
Cryoablation is to utilize the freezing to local organization, controllably histoclastic treatment method.Cryoablation is in gas
In use, compared with heating ablation, freezing does not easily lead to the damage of cartilage in road, and air flue softening seldom occurs, collapses, and prevents after starting
Power is narrow；Cold therapy is less to cause to freeze being adhered for position and surrounding tissue；The cold therapy of controllable depth is to neighbouring
Big blood vessel and tracheae are not easy to cause serious injury, and do not easily cause perforation bleeding, and be conducive to tissue repair；Cryoablation does not promote meat
Bud hyperblastosis, it is not easy to generate cicatricial tissue.
Obstructive lung disease, including asthma, pulmonary emphysema or chronic bronchitis etc., in the U.S., number of the infected is more than 25,000,000
People is estimated to exceed 20,000,000,000 dollars to these disease total costs at present.Due to factors such as air pollution, smokings, disease incidence is
Increase.
Chronic Obstructive Pulmonary Disease (chronic obstructive pulmonary disease, COPD) is a kind of normal
The disease that can be prevented and treated characterized by continuous flow is limited seen, flow limitation carries out sexual development, with air flue and lung
It is dirty related to the chronic inflammatory increased response of toxic granular or gas.The mark of asthma is by the acute of bronchus liner smooth muscle
Dyspneic acute attack caused by (air in lungs channel) is shunk, airway diameter is reduced and increases gas-flow resistance.In asthma
Bronchoconstriction be " reversible " because actual shrinkage by bronchiectasis medicine or can pass through the passage (In of time
Removing causes after the stimulant shunk) it reverses.It is loose or be overexcited however, asthma long-term performance is the inflammation of smooth muscle.
Current main therapeutic modality is drug therapy, rehabilitation, lung volume-reducing operation or surgical operation therapy (as used
Surgical resection nervus pulmonalis keeps the function of nerve completely or partially invalid, can improve asthma or pulmonary emphysema), these treatments
Method or therapeutic effect are unobvious, or can generate serious complication.
Some researches show that damage lung's vagus nerve, acetylcholine can be inhibited to discharge, inhibit smooth muscle contraction, in turn
Improve asthma, COPD symptom, improves lung function.With the development of cryoablation technology and popularizing for application, cryoablation is to control
It treats COPD and provides new idea and method.The characteristics of due to above-mentioned cryoablation and advantage, so that it is particularly suited for air flue
Tissue is particularly suited for the ablation of lung vagus nerve, damage, therefore cryoablation is one kind for lung vagus nerve injury modeling
Suitable method.
The freezing position of current existing cryoablation conduit is mostly sacculus or probe, entire sacculus or probe contacts portion
Position is its damage range, and when using which destination organization, position is nondistinctive is melted, damaged to tissue for entire freezing
Wound, can bring biggish non-essential damage.Such as Chinese patent CN201710816284.5 discloses a kind of band insulation utricule
Cryoablation conduit comprising: tube body and freezing unit, the tube body include along its axially extending cold source inlet chamber, cold
Source return-air chamber and full chamber, the freezing unit are arranged in the body distal end part, including with the cold source inlet chamber and institute
The insulation utricule stating the first utricule of cold source return-air chamber fluid communication and being connected to the full chamber, when first balloon dilatation
When, by filling chamber, it is filled with insulating medium into the insulation utricule, so that region shared by insulation utricule becomes isolation energy and passes
Defeated region is realized and prevents energy transmission of the freezing unit to the corresponding space of adiabatic zone, although the patent is provided with
The insulation utricule of energy is isolated, but its first utricule for being used to melt still is whole situation, there are still damage ranges to draw greatly
The problem of biggish non-essential damage risen.
Summary of the invention
The shortcomings that in order to overcome in the presence of the prior art with it is insufficient, the present invention provides a kind of cryoablation conduit and its phase
The application of pass, the cryoablation conduit are provided with ablation areas, area of insulation at freezing position, on ablation areas axial direction
Length is short as far as possible, at platypelloid type (due to there is biggish cavity for sufficient heat exchange, it is ensured that freezing depth), is formed radial
The flat damage in direction, can effectively reduce inessential tissue damage；Area of insulation can prevent the cooling capacity of refrigerant from transmitting,
It is further reduced the damage to inessential tissue, is realized under damage few as far as possible, thorough ablation targets tissue is particularly suitable for lung
Vagus nerve tissue.
To achieve the above object, the present invention adopts the following technical scheme:
The first aspect of the invention is to provide a kind of cryoablation conduit, including expandable members and with it is described expansible
The pipeline of component connection, is arranged area of insulation and ablation areas in the expandable members, the pipeline include air inlet pipeline and
Return line, the air inlet pipeline, return line are connected to the inner cavity chamber of the expandable members.
Further, the expandable members are provided with expanded condition and contracted state, refrigerant by the air inlet pipeline into
Enter in the expandable members, make the expandable members at expanded condition, the cooling capacity of the area of insulation isolation refrigerant passes
It passs, the ablation areas realizes that cooling capacity transmitting carries out cryoablation, achievees the purpose that treatment, and refrigerant passes through the muffler
Road reflux.
Further, the end of the air inlet pipeline extends into the expandable members, distal end and the expansible structure
The distal end fixed seal connection of part opens up at least one gas outlet on the air inlet pipeline inside the expandable members,.More into
One step, the air inlet pipeline axial same plane position open up at least two symmetrical gas outlet or it is described into
Air pipe respectively opens up at least one gas outlet in axial Different Plane position.
Further, the return line be sheathed on the air inlet pipeline outside or the return line (22) with it is described
Air inlet pipeline (21) is arranged side by side, and the distal end of the return line (22) is fixedly connected with the proximal end of the expandable members, and
It is connected to the inner cavity chamber of the expandable members.
Further, peripherally disposed temperature sensor and/or pressure sensor in the expandable members.Temperature
The type of sensor and/or pressure sensor is any suitable sensor commonly used in the art, wherein temperature sensor
Surface temperature for real-time monitoring expandable members；Pressure sensor is for real-time monitoring expandable members to the pressure of airway walls
Power.
Further, at least 1 graduation mark is arranged in the outer surface of the distal end of the pipeline.Further, the scale
Line is printing graduation mark or engraving graduation mark, and above-mentioned graduation mark is for measuring distance.
Further, the wall thickness of the area of insulation is greater than the wall thickness of the ablation areas.Wherein, the material in 2 regions
It may be the same or different, the region heat-transfer effect thicker from wall thickness in terms of the heat transmitting angle area difference thinner than wall thickness, i.e. thermal insulation areas
Domain can play certain insulation effect.
Further, the area of insulation is identical with the wall thickness of ablation areas, and the area of insulation uses the coefficient of heat conduction
Low material, the ablation areas material high using the coefficient of heat conduction.It will be appreciated that above-mentioned material can be conventional for this field
Any suitable material used, such as the low material of the coefficient of heat conduction are polyvinyl chloride, thermal coefficient: 0.14W/m × K；
The high material of the coefficient of heat conduction is polyamide, thermal coefficient: 0.25W/m × K.
Further, the area of insulation is the multilayered structure with the heat-insulated material of stomata using kinds of interlayer.It is appreciated that
, above-mentioned with the heat-insulated material of stomata can be any suitable material commonly used in the art, such as heat-barrier material uses
Most high molecular materials be made as it is porous, such as: high-incidence foaming polypropylene, expanded polystyrene (EPS), polyurethane foam plastics.
Further, the outer diameter of the ablation areas is greater than the outer diameter of the area of insulation.Further, the ablation
The outer diameter in region is 1.05~1.5 times of the outer diameter of area of insulation；It is highly preferred that the outer wall of the ablation areas is towards outer lug
Hemispherical or near hemispherical structure.
Further, the ablation areas is one or more, and the ablation areas is in axial direction located at Different Plane,
Expandable members are divided into the ablation areas and area of insulation being interspersed in the radial direction by it.
The second aspect of the invention is to provide a kind of freeze melting device containing any above-mentioned cryoablation conduit,
Wherein the freeze melting device includes refrigerant conveying device commonly used in the art, is connected to the air inlet pipeline,
Further include refrigerant reflux unit commonly used in the art, is connected to the return line；In addition it further includes ability
The conventional use of cryoablation conduit guide system in domain and positioning device etc..
The third aspect of the invention is to provide any above-mentioned cryoablation conduit of one kind in building lung's vagus nerve
Application in damage model, wherein lung's vagus nerve injury model is in vitro lung tissue vagus nerve injury model, described
Isolated-lung is tissue-derived in larger animal, such as ox, sheep, pig etc..
The fourth aspect of the invention is a kind of using any above-mentioned cryoablation conduit progress lung's vagus nerve damage
The method of wound comprising following steps: clear target tissue site；It introduces the expandable members of freeze melting device and is pushed
To target tissue；The ablation areas and target tissue for confirming expandable members are coincide；Input refrigerant, make the expandable members at
Expanded condition opens cryoablation program, carries out cryoablation to appointed part, to complete to damage lung's vagus nerve.
Further, above-mentioned target tissue is in vitro lung tissue.
Further, the method for lung's vagus nerve injury includes the following steps: the targeting of clearly in vitro lung tissue
Position；Under endoscope monitoring, introduce the cryoablation conduit, the cryoablation conduit include expandable members and with institute
The pipeline of expandable members proximal end connection is stated, the expandable members are provided with expanded condition and contracted state, push the freezing and disappear
Melt conduit and reach target tissue, and makes the distally extending distal portions beyond endoscope in the distal end of the cryoablation conduit；Really
Recognize damage location and target tissue coincide；Refrigerant is inputted, the expandable members is made to open cryoablation program at expanded condition,
The cryoablation program includes cryoablation process and rewarming process, carries out cryoablation to appointed part, reaches damage lung
Portion's vagus nerve purpose.
Further, the target tissue can be multiple target tissues, can be, but not limited to as left principal bronchus, right main branch
Tracheae, or simultaneously include left and right main bronchus.
Further, the target tissue can all carry out cryoablation primary, can also be performed in multiple times freezing and disappear
Melt.
Further, described that endoscope is introduced into step, lung's airmanship can be combined.
Further, the cryoablation conduit step is introduced, the channel through the endoscope itself is can be and introduces,
It can be the cryoablation conduit to introduce side by side with the endoscope.
Further, the confirmation operative site and target tissue anastomosis procedure, can line-of-sight observation, can also combine a variety of
Detection method, such as X-ray machine.
Further, cryoablation program is opened, the cryoablation program includes cryoablation process and rewarming process,
Cryoablation is carried out to appointed part, reaches the damage vagal purpose of lung, it can be multiple to the same target tissue multiple cold
Freeze ablation lesions, to reach better cryoablation damage effect.
Further, the refrigerant is liquid nitrogen, can also be other suitable refrigerants.
The present invention by adopting the above technical scheme, has the following technical effect that
1. while reaching damage lung's vagus nerve, being realized using the interventional method of endoscope cooperation cryoablation
Wound is small, operating time is short, easy to operate, highly-safe, while the complication of effectively control operation；
2. being provided with area of insulation, ablation areas in expandable members, the relatively major lumen due to expandable members is for filling
Divide heat exchange, the length of ablation areas in the axial direction can be shorter, had not only been able to achieve the vagal damage of lung, but also can subtract as far as possible
The damage of few inessential tissue；
3. being provided with area of insulation on refrigerating plant, in ablation procedure, isolation cooling capacity transmitting is further protected inessential
Injury tissue；
4. the central cross-section of ablation areas in axial direction can be Different Plane, i.e., along axial Disjunct distribution, formed axial
Upper interruption damages (incomplete circumferential damage), and interruption damage can reduce the stimulation of the damage to airway walls tissue, is not easy to cause
The complication such as perforation, Airway Collapse, while can guarantee lung's vagus nerve injury again, stop nerve conduction.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of cryoablation conduit in one embodiment of the invention.
Fig. 2 is the cross-sectional view of cryoablation conduit in one embodiment of the invention.
Fig. 3 is enlarged drawing at the A of cryoablation conduit shown in Fig. 2.
Fig. 4 is the cross-sectional view of cryoablation conduit in another embodiment of the present invention.
Fig. 5 is the cross-sectional view of cryoablation conduit in another embodiment of the present invention.
Fig. 6 is the cross-sectional view of cryoablation conduit in another embodiment of the present invention.
Fig. 7 is the cross-sectional view of cryoablation conduit in another embodiment of the present invention.
Fig. 8 is the cross-sectional view of cryoablation conduit in another embodiment of the present invention.
Wherein, appended drawing reference are as follows:
Expandable members 1；Area of insulation 11；Ablation areas 12；Pipeline 2；Air inlet pipeline 21；Return line 22；Graduation mark
23；Gas outlet 211.
Specific embodiment
The present invention relates to a kind of cryoablation conduits, including expandable members and the pipe connecting with the expandable members
Road, is arranged area of insulation and ablation areas in the expandable members, and the pipeline includes air inlet pipeline and return line, described
Air inlet pipeline, return line are connected to the inner cavity chamber of the expandable members.The invention further relates to above-mentioned cryoablation conduits
Application.
With reference to the accompanying drawings and examples, further description of the specific embodiments of the present invention.Following embodiment is only
For clearly illustrating technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
The present embodiment is the cryoablation conduit of a preferred construction form.As shown in Figures 1 to 3, described in the present embodiment
Cryoablation conduit includes expandable members 1 and the pipeline 2 that connect with 1 proximal end of expandable members, is set in expandable members 1
It is equipped with the ablation areas 12 positioned at the area of insulation 11 of two sides and positioned at middle part, the area of insulation 11 and ablation areas 12 are common
The expandable members 1 are formed, the main body of the expandable members 1 is cylinder form, and both ends are respectively cone form
The quantity of sealing structure, the annular band forms that the ablation areas 12 is 360 °, ablation areas 12 is 1, and width is about
The 1/4~1/3 of 1 principal length of expandable members；Wherein, the area of insulation 11 is identical with the material of ablation areas 12, specifically
It can be polyamide material, but the wall thickness of area of insulation 11 is greater than the wall thickness of ablation areas 12, specifically about 2~4 times, transmits from heat
Angle sees that the thicker region heat-transfer effect of the wall thickness area difference thinner than wall thickness, i.e. area of insulation 11 can play certain insulation effect
Fruit.
In the present embodiment, pipeline 2 includes the air inlet pipeline 21 and return-air being connected to respectively with the inner cavity chamber of expandable members 1
Pipeline 22, the end of air inlet pipeline 21 extend into expandable members 1, and distal end and the distal end fixing seal of expandable members 1 connect
It connects, 2 symmetrical gas outlets is opened up on the side wall that expandable members 1 are internally located at the air inlet pipeline 21 in middle position
211, return line 22 is sheathed on the outside of air inlet pipeline 21, and distal end is fixedly connected with the proximal end of the expandable members, tool
Body structure is the casing for extending sealing shroud from the conical end of the proximal end of expandable members 1 outside return line 22,
The distal end of return line 22 is connected in the proximal end of expandable members 1 with its inner cavity chamber.
In the present embodiment, at least 1 graduation mark 23 is arranged in the outer surface of the distal end of return line 22, which is
Print graduation mark or engraving graduation mark, peripherally disposed temperature sensor and pressure sensor in expandable members 1.
In the present embodiment, expandable members 1 are provided with expanded condition and contracted state, and refrigerant (such as liquid nitrogen) is by air inlet
Gas outlet 211 that 21 side wall of pipeline opens up enters in expandable members 1, makes expandable members 1 at expanded condition, area of insulation 11 every
Cooling capacity transmitting from refrigerant, ablation areas 12 realize that cooling capacity transmitting carries out cryoablation, achieve the purpose that treatment, freezing are situated between
Matter is flowed back by return line 22.
Embodiment 2
The present embodiment is the cryoablation conduit of another preferred construction form.As shown in figure 4, freezing described in the present embodiment
Ablation catheter structure is substantially the same manner as Example 1, the difference is that only: area of insulation 11 and ablation areas 12 are with identical
Wall thickness, but the material that the two uses is different, the material low using the coefficient of heat conduction of area of insulation 11, specially polyvinyl chloride material
Matter；The material high using the coefficient of heat conduction of ablation areas 12, specially polyamide material.
Embodiment 3
The present embodiment is the cryoablation conduit of another preferred construction form.As shown in figure 5, freezing described in the present embodiment
Ablation catheter structure is substantially the same manner as Example 1, the difference is that only: area of insulation 11 and ablation areas 12 are with identical
Wall thickness, and the material that the two uses may be the same or different, and the outer diameter of ablation areas 12 is greater than the outer diameter of area of insulation 11, tool
Body is that the outer wall of ablation areas 12 is hemispherical or near hemispherical structure towards outer lug, and the outer diameter of ablation areas 12 is heat-insulated
1.05~1.5 times of the outer diameter in region 11.In the present embodiment, when expandable members 1 are in expansion state, due to zone of ablation
The outer diameter in domain 12 is larger, so that it can preferentially be contacted with to damage location, to realize the purpose of freezing partly ablation.
Embodiment 4
The present embodiment is the cryoablation conduit of another preferred construction form.As shown in fig. 6, freezing described in the present embodiment
Ablation catheter structure is substantially the same manner as Example 1, the difference is that only: the outer diameter phase of area of insulation 11 and ablation areas 12
Together, and there is identical or different wall thickness, the material that the two uses may be the same or different, when wall thickness difference, area of insulation
11 wall thickness is greater than the wall thickness of ablation areas 12；When material difference, the material low using the coefficient of heat conduction of area of insulation 11, tool
Body is polyvinyl chloride material, and area of insulation is the multilayered structure with the heat-insulated material of stomata using kinds of interlayer；Ablation areas
12 materials high using the coefficient of heat conduction, specially polyamide material；In addition, the quantity of ablation areas 12 is 2, it is
360 ° of annular band forms open up 2 symmetrical outlets on the side wall of air inlet pipeline 21 corresponding with each ablation areas 12
Mouth 211, ablation areas 12 is spaced apart with area of insulation 11.
Embodiment 5
The present embodiment is the cryoablation conduit of another preferred construction form.As shown in fig. 7, freezing described in the present embodiment
Ablation catheter structure is substantially the same manner as Example 1, the difference is that only: area of insulation 11 and ablation areas 12 are with identical
Or different wall thickness, the material that the two uses may be the same or different, and when wall thickness difference, the wall thickness of area of insulation 11, which is greater than, to disappear
The wall thickness in tabetisol domain 12；When material difference, the material low using the coefficient of heat conduction of area of insulation 11, specially polyvinyl chloride material
Matter；The material high using the coefficient of heat conduction of ablation areas 12, specially polyamide material；In addition, the quantity of ablation areas 12 is 2
It is a, it is 180 ° of ring structure form, each ablation areas 12 is in axial direction located at Different Plane, by expandable members
Be divided into the ablation areas 12 and area of insulation 11 being interspersed in the radial direction, specially expandable members 1 be separated into as
Two parts symmetrical above and below shown in Fig. 7, the first side of upper part are ablation areas 12, and second side of upper part is area of insulation
11, the first side of lower part corresponding with upper the first side of part is area of insulation 11, lower part corresponding with upper part second side
Second side be ablation areas 12, the side wall of air inlet pipeline 21 corresponding with each ablation areas 12 opens up one or more and goes out
Port.
Embodiment 6
The present embodiment is the cryoablation conduit of another preferred construction form.As shown in figure 8, freezing described in the present embodiment
Ablation catheter structure is substantially the same manner as Example 1, the difference is that only: area of insulation 11 and ablation areas 12 are with identical
Or different wall thickness, the material that the two uses may be the same or different, and when wall thickness difference, the wall thickness of area of insulation 11, which is greater than, to disappear
The wall thickness in tabetisol domain 12；When material difference, the material low using the coefficient of heat conduction of area of insulation 11, specially polyvinyl chloride material
Matter；The material high using the coefficient of heat conduction of ablation areas 12, specially polyamide material；And the quantity of ablation areas 12 is 2,
It is 180 ° of annular band forms, and the outer diameter of ablation areas 12 is greater than the outer diameter of area of insulation 11, specially ablation areas
12 outer wall is the hemispherical or near hemispherical structure towards outer lug, and each ablation areas 12 is in axial direction located at different flat
Expandable members are divided into the ablation areas 12 and area of insulation 11 being interspersed by face, and specially expandable members are divided
It is divided into symmetrical two parts as shown in Figure 8, left half is from top to bottom divided into area of insulation 11, ablation areas 12 and heat-insulated
Region 11, right half are from top to bottom divided into area of insulation 11, ablation areas 12 and area of insulation 11, but the two-part ablation in left and right
Not in the same plane, the side wall of air inlet pipeline 21 corresponding with each ablation areas 12 opens up 1 gas outlet in region 12.
Embodiment 7
The present embodiment is to carry out lung's vagus nerve damage using cryoablation conduit described in any one of Examples 1 to 6
The method of wound comprising following steps: the target location of clearly in vitro lung tissue；Under endoscope monitoring, cryoablation is introduced
Conduit, cryoablation conduit include expandable members and the pipeline that connect with expandable members proximal end, and expandable members are provided with
Expanded condition and contracted state push the cryoablation conduit and reach target tissue, and prolong the distal end of cryoablation conduit distad
Stretch the distal portions beyond endoscope；Confirm that damage location and target tissue coincide；Refrigerant is inputted, makes expandable members at expansion
State is opened, cryoablation program is opened, cryoablation program includes cryoablation process and rewarming process, is carried out to appointed part cold
Freeze ablation, reaches damage lung's vagus nerve purpose.
Above-mentioned target tissue can be left principal bronchus, right principal bronchus, or simultaneously include left and right main bronchus；Above-mentioned target group
It knits, can all carry out cryoablation primary, cryoablation can also be performed in multiple times；Endoscope is being introduced into step, it can
To combine lung's airmanship；Wherein, the cryoablation conduit step is introduced, can be the channel through the endoscope itself
It introduces, is also possible to the cryoablation conduit and is introduced side by side with the endoscope；Wherein, confirmation operative site and target tissue are kissed
Step is closed, can be line-of-sighted observation, it can also be in conjunction with a variety of detection methods, such as X-ray machine；Wherein, cryoablation program includes freezing
Ablation procedure and rewarming process carry out cryoablation to appointed part, reach the damage vagal purpose of lung, can be to same
The multiple multiple cryoablation damage of one target tissue, to reach better cryoablation damage effect.
As can be seen from the above embodiments, the present invention is according to pulmonary airways structure, using endoscope, when having small wound, operation
Length, highly-safe advantage；Cryoablation air flue application compared with heating ablation with high security, to airway walls structural damage
It is small, be not easy to cause the complication such as airway constriction；Cooperate cryoablation method using endoscope, while reaching injuring nerve,
Effectively control the complication of the ablation method；Lung's vagus nerve is located on the outside of airway walls, using intervening cryoablation in air flue
When mode damages lung vagus nerve, in order to achieve the effect that neurotrosis, the present invention has disappearing for expandable members using end
Melt conduit, have biggish utricule (cavity) to be used for abundant cooling capacity heat exchange when being in expansion state, so that freezing be made to damage
Wound penetrates entire airway walls, reduces the damage of inessential tissue to the greatest extent with area of insulation in expandable members setting ablation.
Specific embodiments of the present invention are described in detail above, but it is only used as example, the present invention is not intended to limit
In particular embodiments described above.To those skilled in the art, the equivalent modifications and replace that any couple of present invention carries out
In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair
Change, all should be contained within the scope of the invention.
Claims (13)
1. a kind of cryoablation conduit, including expandable members (1) and the pipeline (2) being connect with the expandable members (1),
Be characterized in that, area of insulation (11) and ablation areas (12) be set on the expandable members (1), the pipeline (2) include into
Air pipe (21) and return line (22), the air inlet pipeline (21), return line (22) with the expandable members (1)
Inner cavity chamber's connection.
2. a kind of cryoablation conduit according to claim 1, which is characterized in that prolong the end (21) of the air inlet pipeline
It protrudes into the expandable members (1), the distal end fixed seal connection of distal end and the expandable members (1) is expanded described
It opens and opens up at least one gas outlet (211) on component (1) internal air inlet pipeline (21).
3. a kind of cryoablation conduit according to claim 2, which is characterized in that the return line (22) is sheathed on institute
The outside or the return line (22) for stating air inlet pipeline (21) are arranged side by side with the air inlet pipeline (21), the return line
(22) distal end is fixedly connected with the proximal end of the expandable members (1), and is connected with the inner cavity chamber of the expandable members (1)
It is logical.
4. a kind of cryoablation conduit according to claim 1, which is characterized in that along circle on the expandable members (1)
Temperature sensor and/or pressure sensor is arranged in circumferential direction.
5. a kind of cryoablation conduit according to claim 1, which is characterized in that the appearance of the distal end of the pipeline (2)
At least 1 graduation mark (23) is arranged in face.
6. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation
(11) wall thickness is greater than the wall thickness of the ablation areas (12).
7. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation
(11) identical with the wall thickness of ablation areas, the area of insulation (11) material low using the coefficient of heat conduction, the ablation areas
(12) material high using conduction-convection problem.
8. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the area of insulation
It (11) the use of kinds of interlayer is the multilayered structure with the heat-insulated material of stomata.
9. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the ablation areas
(12) outer diameter is greater than the outer diameter of the area of insulation (11).
10. a kind of cryoablation conduit according to any one of claims 1 to 5, which is characterized in that the ablation areas
It (12) is one or more, the ablation areas (12) is in axial direction located at Different Plane, and expandable members (1) is separated
For the ablation areas (12) and area of insulation (11) being interspersed in the radial direction.
11. a kind of freeze melting device containing cryoablation conduit according to any one of claims 1 to 5.
12. a kind of if cryoablation conduit according to any one of claims 1 to 5 is in building lung's vagus nerve injury model
In application.
13. a kind of side for carrying out lung's vagus nerve injury using cryoablation conduit according to any one of claims 1 to 5
Method, which comprises the following steps: clear target tissue site；The expandable members (1) of introducing freeze melting device simultaneously will
It pushes to target tissue；The ablation areas (12) and target tissue for confirming expandable members (1) are coincide；Refrigerant is inputted, institute is made
Expandable members (1) are stated into expanded condition,；Cryoablation program is opened, cryoablation is carried out to appointed part, to complete damage lung
Portion's vagus nerve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910810512.7A CN110507406A (en) | 2019-08-29 | 2019-08-29 | Cryoablation catheter and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910810512.7A CN110507406A (en) | 2019-08-29 | 2019-08-29 | Cryoablation catheter and application thereof |
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Family
ID=68629205
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| CN201910810512.7A Pending CN110507406A (en) | 2019-08-29 | 2019-08-29 | Cryoablation catheter and application thereof |
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