CN110338790B - Flexible fingerstall for collecting surface myoelectricity and various physiological parameters - Google Patents

Flexible fingerstall for collecting surface myoelectricity and various physiological parameters Download PDF

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CN110338790B
CN110338790B CN201910594638.5A CN201910594638A CN110338790B CN 110338790 B CN110338790 B CN 110338790B CN 201910594638 A CN201910594638 A CN 201910594638A CN 110338790 B CN110338790 B CN 110338790B
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flexible
myoelectricity
finger
fingerstall
collecting
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CN110338790A (en
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董树荣
魏旭辉
郭维
谢臻蔚
李文娟
钟霜霜
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Zhejiang Heqing Flexible Electronic Technology Co ltd
Zhejiang University ZJU
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Zhejiang University ZJU
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022Monitoring a patient using a global network, e.g. telephone networks, internet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/389Electromyography [EMG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802Sensor mounted on worn items
    • A61B5/6804Garments; Clothes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation

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Abstract

The invention discloses a flexible fingerstall for collecting surface myoelectricity and various physiological parameters, which comprises a flexible fingerstall substrate matched with the shape of a finger; the outer surface of the flexible fingerstall base at the position corresponding to the finger pulp of the first knuckle of the finger is provided with a myoelectric acquisition electrode, and the outer surface of the flexible fingerstall base at the position corresponding to the finger back of the first knuckle of the finger is provided with a physiological parameter sensor; the myoelectricity collecting electrode and the physiological parameter sensor are respectively and electrically connected with a collecting and processing circuit arranged at the bottom end of the outer surface of the flexible fingerstall substrate through a buckling line; the outer surface of the flexible fingerstall substrate is provided with a transparent isolation layer film, and the transparent isolation layer film coats the part of the outer surface of the flexible fingerstall substrate except the myoelectricity acquisition electrode. The invention is convenient to use, and can ensure that the electrode is well contacted with the skin; besides the body surface, the finger stall shaped structure can also be applied to physiological structures such as anus, vagina, pelvic floor and the like.

Description

Flexible fingerstall for collecting surface myoelectricity and various physiological parameters
Technical Field
The invention belongs to the field of biomedical engineering, and particularly relates to a flexible fingerstall for acquiring surface myoelectricity and various physiological parameters.
Background
With the development of medical level, people pay more and more attention to the health level, and medical equipment is not only used for disease diagnosis and intra-operative monitoring, but also used for postoperative rehabilitation monitoring and daily household life. The surface electromyogram collection is used as a non-invasive method capable of well representing the muscle state, and is widely applied to clinical diagnosis, rehabilitation training and scientific research.
Chinese patent publication No. CN109124628A discloses a myoelectricity collecting device based on flexible active electrodes, which comprises a device main body, wherein the device main body comprises an electrode array, a signal conditioning circuit and a signal collecting device; the electrode array is connected with the signal acquisition device through the signal conditioning circuit, and the electromyographic signals acquired by the electrode array are adjusted by the signal conditioning circuit and then transmitted to the signal acquisition device; an impedance conversion circuit is arranged between the electrode array and the signal conditioning circuit. The device can reduce the influence of electrode skin contact impedance on the electromyographic signals, reduce the interference of power frequency noise, and obtain surface electromyographic signals with higher quality and lower noise.
In the traditional electromyography acquisition, corresponding electromyography signals are acquired by placing electrodes on the body surface, and data transmission is carried out in a wired or wireless mode. However, for some applications, such as collecting electrical signals from the internal muscle of the anus, the pelvic region and the vagina, a customized rod-shaped electrode is needed. In addition to the inconvenience of use, the rod-shaped electrode has another disadvantage that it is impossible to determine which muscle group the electrode contacts, and the position needs to be adjusted repeatedly. An experienced doctor can determine the positions of muscle groups through finger touch, so that if the myoelectric acquisition equipment in the shape of a glove is provided, the positions of the muscle groups can be quickly positioned, myoelectric signals of parts including a body surface, an anus, a basin, a vagina and the like can be conveniently acquired, and the myoelectric acquisition equipment has important clinical application value.
In addition, for diagnosis and rehabilitation evaluation, a plurality of physiological indexes are required to be considered simultaneously for comprehensive judgment. For example, when the recovery of muscles in anus and vagina is evaluated after operation and production, besides measuring the electric signals of surface muscles, physiological parameters such as blood oxygen concentration, heart rate, blood pressure, lactic acid and the like need to be monitored. Therefore, the conventional measurement method usually uses a plurality of devices on the patient at the same time to ensure the monitoring of various physiological parameters, and is very inconvenient to use.
Disclosure of Invention
The invention provides a flexible finger stall for collecting surface myoelectricity and various physiological parameters, which can collect the surface myoelectricity and various physiological parameters of body surface, anus, vagina and pelvic floor, wherein the physiological parameters comprise blood oxygen concentration, pH value and lactic acid concentration.
The technical scheme of the invention is as follows:
a flexible finger cot used for collecting surface myoelectricity and a plurality of physiological parameters comprises a flexible finger cot substrate matched with the shape of a finger; the outer surface of the flexible fingerstall base at the position corresponding to the finger pulp of the first knuckle of the finger is provided with a myoelectric acquisition electrode, and the outer surface of the flexible fingerstall base at the position corresponding to the finger back of the first knuckle of the finger is provided with a physiological parameter sensor; the myoelectricity collecting electrode and the physiological parameter sensor are respectively and electrically connected with a collecting and processing circuit arranged at the bottom end of the outer surface of the flexible fingerstall substrate through a stretchable buckling line;
the outer surface of the flexible fingerstall substrate is provided with a transparent isolation layer film, and the transparent isolation layer film coats the part of the outer surface of the flexible fingerstall substrate except the myoelectricity acquisition electrode.
In the invention, the flexible finger stall substrate is made of high molecular polymer materials, and comprises latex, polyurethane or composite nano materials. The stretching amount of the finger stall in the major axis direction is 0-50%, the stretching amount of the finger stall in the minor axis direction is 0-30%, and the thickness of the finger stall is 0.05-5 mm. By virtue of its excellent extensibility, fingers of different sizes can be adapted. The flexible circuit board carrying the myoelectricity collecting electrode, the physiological parameter sensor and the collecting and processing circuit is adhered to the flexible fingerstall base.
The myoelectricity collecting electrode is at least two, each myoelectricity collecting electrode is circular, the radius is 1-5 mm, the thickness is 1-500 um, and the myoelectricity collecting electrode is made of biocompatible metal and comprises copper, gold, platinum, silver or silver chloride and the like. The myoelectricity collecting electrode is placed on the finger pulp of the first knuckle of the finger corresponding to the finger sleeve, so that the muscle group can be conveniently positioned through finger pressing.
The physiological parameter sensor is arranged at the back of the finger corresponding to the first knuckle of the finger, and can monitor three physiological parameter indexes of blood oxygen concentration, PH value and lactic acid content.
The myoelectricity collecting electrode and the physiological parameter sensor are respectively connected to the collecting and processing circuit through S-shaped buckling lines. The S-shaped buckling line has 0% -50% of stretching amount, so that the connecting line has the same stretching capacity when the base of the finger sleeve is stretched, and the occurrence of fracture is avoided.
The plate making of the acquisition processing circuit adopts a flexible circuit board made of polyimide PI materials, and the flexible circuit board is arranged at the bottom end of the outer surface of the flexible fingerstall base in a surrounding mode.
The acquisition processing circuit comprises an anti-aliasing low-pass filter, an amplification module, an AD conversion module and a microprocessor which are sequentially connected, and the microprocessor is also connected with a Bluetooth module and a UART interface which are used for exchanging data with an upper computer;
the myoelectricity collecting electrode is connected with an anti-aliasing low-pass filter of the collecting and processing circuit through a buckling curve; the physiological parameter sensor is connected with the microprocessor of the acquisition processing circuit through a buckling curve.
The anti-aliasing low-pass filter is used for filtering out-of-band noise when the surface electromyographic signals are collected; the amplification module is adjustable in gain, the adjustable range is 1-24, and the amplification module is used for amplifying the low-pass filtered signal and improving the signal-to-noise ratio; the AD conversion module adopts a 24-bit sigma-delta type oversampling ADC for quantizing the voltage signal into a digital signal; the Bluetooth module and the UART interface are used for interacting data with an upper computer and are compatible with Bluetooth wireless transmission and serial port wired transmission.
The transparent isolation layer film is formed by spin coating biocompatible polydimethylsiloxane PDMS on the outer surface of the flexible fingerstall substrate on which the acquisition processing circuit is stuck, and redundant PDMS is removed from each myoelectricity acquisition electrode disc to expose the electrode, so that good contact between the electrode and the skin is ensured. The non-conductive, biocompatible PDMS isolates the circuitry (except for the electrodes needed to contact the inner skin) from the moist environment in the anus, pelvic floor, vagina.
Compared with the prior art, the invention has the following beneficial effects:
the invention has the functions of surface myoelectricity acquisition and physiological parameter index acquisition, and has high reusability; the base of the finger sleeve and the acquisition processing circuit are both made of flexible materials, so that the finger sleeve is convenient to use, and the electrode can be well contacted with the skin; the shape structure of the finger stall can be applied to physiological structures such as anus, vagina, pelvic floor and the like besides the body surface; the battery is adopted to supply power for the acquisition and processing circuit, and the selectable wired/wireless transmission mode and the volume of the finger size are more in line with the development trend of miniaturization and convenience of the biosensor.
Drawings
FIG. 1 is a structural diagram of a flexible finger cot for collecting surface myoelectricity and various physiological parameters, wherein the left side is a front view and the right side is a rear view;
FIG. 2 is a schematic cross-sectional view of a flexible finger cot for collecting surface myoelectricity and various physiological parameters according to the present invention;
FIG. 3 is a schematic diagram of an acquisition processing circuit in a flexible fingerstall for acquiring surface myoelectricity and various physiological parameters according to the present invention;
FIG. 4 is a time domain graph of an electromyographic signal obtained when measuring a surface electromyographic signal according to an embodiment of the present invention;
FIG. 5 is a graph of measured oximetry values in accordance with an embodiment of the present invention;
fig. 6 is a usage state diagram of the embodiment of the invention, wherein (a) shows the collection of physiological parameters, and (b) shows the collection of surface electromyographic signals.
Detailed Description
The invention will be described in further detail below with reference to the drawings and examples, which are intended to facilitate the understanding of the invention without limiting it in any way.
As shown in fig. 1 and 2, a flexible finger cot for collecting surface myoelectricity and various physiological parameters comprises a flexible finger cot substrate 4, a myoelectricity collecting electrode 1, a physiological parameter sensor 2, a collecting and processing circuit 3 and a transparent isolation layer film 5.
The flexible finger sleeve substrate 4 is matched with the finger in shape, has good ductility and is made of ductile high polymer material latex. The thickness of the finger stall is 0.1 mm. By virtue of its excellent extensibility, fingers of different sizes can be adapted.
The myoelectricity collecting electrode 1 is placed on the finger pulp of the first knuckle of the finger corresponding to the finger sleeve, so that the muscle group can be conveniently positioned through finger pressing. The number of the electrodes is four, each electrode is in a circular shape with the radius of 2mm, the thickness of the electrode is 200um, and the electrode is made of metal copper. Each electrode is connected to the acquisition processing circuit 3 by an S-flex wire. The S-shaped buckling line has 0% -50% of stretching amount, so that the connecting line has the same stretching capacity when the base of the finger sleeve is stretched, and the occurrence of fracture is avoided.
The physiological parameter sensor 2 is arranged at the back of the finger corresponding to the first knuckle of the finger, and can monitor three physiological parameter indexes of blood oxygen concentration, PH value and lactic acid content. The output of the physiological parameter sensor 2 is connected to the acquisition processing circuit 3 through an S-shaped buckling line. Similarly, the S-shaped buckling line has an amount of stretching of 0% to 50%.
The transparent isolation layer film 5 is formed by spin-coating polydimethylsiloxane PDMS on the flexible finger stall substrate 4 which is pasted with the flexible circuit board, and then hollowing out the flexible finger stall substrate to expose the disc of the myoelectricity acquisition electrode 1.
As shown in fig. 3, the acquisition processing circuit 3 includes an anti-aliasing low pass filter 31, an amplification module 32, an AD conversion module 33, and a microprocessor 34, which are connected in sequence, and the microprocessor 34 is further connected with a bluetooth module 35 and a UART interface 36 for exchanging data with an upper computer, and can select wired data transmission or bluetooth transmission. The myoelectricity collecting electrode 1 is connected with an anti-aliasing low-pass filter 31 of the collecting and processing circuit 3 through a buckling curve; the physiological parameter sensor 2 is connected with the microprocessor 34 of the acquisition processing circuit 3 through a buckling curve.
The working principle of the myoelectricity collecting electrode 1 is as follows: myoelectric signals generated by muscle actions are conducted to the skin surface layer through skin to generate surface myoelectric signals, the electrodes acquire potential differences between the channels and the reference electrodes, the potential differences are converted into digital signals after filtering, amplification and analog-to-digital conversion, and the digital signals are processed by the microprocessor 34 and then transmitted to an upper computer through the Bluetooth module 35 in a wireless mode or the UART interface 36 in a wired mode.
The working principle of the physiological parameter sensor 2 is as follows: the physiological parameter sensor 2 is a reflective photoelectric sensor. Different LEDs emit light with different wavelengths, and the light is reflected back to the photoelectric receiving tube after passing through the transparent isolating layer film and the sensitive film. Because the concentration of the specific sensitive film to the specific physiological parameter value can generate color change, the absorbance of the sensitive film to a fixed wavelength is changed. The photoelectric receiving tube generates photoelectric current or photoelectric voltage after receiving the optical signal, and the corresponding value of the physiological parameter can be calculated by checking the voltage/current.
The anti-aliasing low-pass filter 31 realizes the removal of out-of-band noise at the nyquist sampling rate, and because the AD conversion module 33 adopts the oversampling technology and the sampling frequency is 1.025MHz, the requirement on the front-end anti-aliasing low-pass filter 31 is reduced, and the attenuation above-60 dB of a stop band can be achieved by adopting a first-order RC filter. In order to reduce system noise, analog band-pass filtering and notch design are not carried out on a hardware part, but the analog band-pass filtering and notch design is carried out through a digital filter of an upper computer.
The AD conversion module 33 employs an oversampling ADC to effectively average the ADC quantization noise over a wider frequency band, thereby reducing the noise level over the effective signal band. Meanwhile, the oversampling technology enables the anti-aliasing filter to achieve attenuation above-60 dB at the expected cut-off frequency with a low roll-off coefficient.
The microprocessor 34 adopts a lightweight MCU CC2541 of TI company, converts the collected electromyographic signals and sensor values into corresponding voltage values and physiological parameter values, and outputs or transmits the voltage values and the physiological parameter values to the Bluetooth module 35 through the UART interface 36 for wireless transmission.
In order to verify the effectiveness of the present invention, the present embodiment separately collects the surface myoelectric signal and the blood oxygen concentration physiological parameter.
As shown in fig. 3, the modules used for surface electromyogram signal acquisition include an electromyogram acquisition electrode 1, an anti-aliasing filter 31, an amplification module 32, an AD conversion module 33, a microprocessor 34, a bluetooth module 35, and a UART interface 36.
After the forefinger wears the finger sleeve, the position of the finger sleeve is adjusted to enable the finger sleeve myoelectricity acquisition electrode round disc to be positioned at the finger abdomen of the first knuckle. The forefinger presses the muscle to be measured to ensure that the electrode is well contacted with the skin, and the signal is transmitted to the anti-aliasing filter 31 through the myoelectricity acquisition electrode 1 to filter out high-frequency out-of-band noise; the filtered signal enters an amplifying module 32 for gain amplification; the amplified signal enters an AD conversion module 33, and is converted into a 16-bit digital signal, and the digital signal enters a microprocessor 34 for voltage value recovery. The ADC 16-bit digital signal outputs the complement of the quantized recovered value. The recovery formula is as follows:
Vmyoelectricity=VADC/G (1)
Wherein, VADCIs a numerical value converted by ADC 16-bit complement, and the unit is uV; g is the amplification block gain, value 24; vMyoelectricityIs the value of the recovered myoelectric voltage with the unit of uV.
After obtaining the recovered data, the microprocessor 34 packages the data and outputs the data through the bluetooth module 35 and the UART interface 36.
FIG. 4 is a 4-channel surface electromyographic waveform collected using the present device. The motor electrical signals of the muscle at the electrode contact can be seen at different times.
The modules used for collecting the surface physiological parameters comprise a physiological parameter sensor 2, a microprocessor 34, a Bluetooth module 35 and a UART interface 36.
The outer of the isolation layer film of the photoelectric physiological parameter sensor 2 is coated with a glucose sensitive film, a PH sensitive film and a lactic acid sensitive film, when the finger sleeve is sleeved on the forefinger, the position of the finger sleeve is adjusted to enable the physiological parameter sensor to be located at the first knuckle of the forefinger, the forefinger is close to a tissue to be detected, the sensitive film on the finger sleeve is lightly contacted with the skin, and after the sensitive film is contacted with the skin, corresponding color changes are generated according to different blood oxygen concentrations, so that the light absorption rate of the sensitive film to specific wavelength light is changed. The light with specific wavelength emitted by the LED in the physiological parameter sensor 2 passes through the transparent isolation film and the sensitive film and then is reflected back to the photoelectric receiving tube, and besides the light energy lost by scattering and refraction, part of the light energy is absorbed by the sensitive film, so that the numerical value corresponding to the physiological parameter can be calculated according to the light current or the light voltage of the photoelectric receiving tube. The photoelectric voltage and the photocurrent generated by the photoelectric receiving tube are collected and then transmitted to the microcontroller 34, and the microcontroller 34 converts the photovoltage and the photocurrent into corresponding physiological parameter values and then transmits the physiological parameter values to an upper computer through the Bluetooth module 35 or the UART interface 36.
Fig. 5 shows the blood oxygen values collected by the device. The blood oxygen concentration value was maintained around 98% during the 10s acquisition.
As shown in fig. 6, the usage state diagram of the flexible finger cot of the present invention is shown, wherein (a) shows the state that the physiological parameter sensor faces upwards for collecting physiological parameters, and (b) shows the state that the myoelectricity collecting electrode faces upwards for collecting surface myoelectricity signals.
The embodiments described above are intended to illustrate the technical solutions and advantages of the present invention, and it should be understood that the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the present invention, and any modifications, additions and equivalents made within the scope of the principles of the present invention should be included in the scope of the present invention.

Claims (3)

1. A flexible fingerstall for collecting surface myoelectricity and various physiological parameters is characterized by comprising a flexible fingerstall substrate matched with the shape of a finger; the outer surface of the flexible fingerstall base at the position corresponding to the finger pulp of the first knuckle of the finger is provided with a myoelectric acquisition electrode, and the outer surface of the flexible fingerstall base at the position corresponding to the finger back of the first knuckle of the finger is provided with a physiological parameter sensor; the myoelectricity collecting electrode and the physiological parameter sensor are respectively and electrically connected with a collecting and processing circuit arranged at the bottom end of the outer surface of the flexible fingerstall substrate through a buckling line; the bending curve is an S-shaped bending curve; the physiological parameter sensor is a reflective photoelectric sensor;
at least two myoelectricity collecting electrodes are arranged; each myoelectricity collecting electrode is circular, the radius is 1-5 mm, the thickness is 1-500 um, and the materials are copper, gold, platinum, silver or silver chloride;
the outer surface of the flexible fingerstall substrate is provided with a transparent isolating layer film, and the transparent isolating layer film coats the part of the outer surface of the flexible fingerstall substrate except the myoelectricity collecting electrode;
the flexible fingerstall substrate is made of a high-molecular polymer material, the high-molecular polymer material is latex, polyurethane or a composite nano material, and the thickness of the flexible fingerstall substrate is 0.05-5 mm; the plate making of the acquisition processing circuit adopts a flexible circuit board made of polyimide PI materials, and the flexible circuit board is arranged at the bottom end of the outer surface of the flexible fingerstall base in a surrounding mode.
2. The flexible fingerstall for acquiring surface myoelectricity and multiple physiological parameters according to claim 1, wherein the acquisition processing circuit comprises an anti-aliasing low-pass filter, an amplification module, an AD conversion module and a microprocessor which are sequentially connected, and the microprocessor is further connected with a Bluetooth module and a UART interface which are used for exchanging data with an upper computer;
the myoelectricity collecting electrode is connected with an anti-aliasing low-pass filter of the collecting and processing circuit through a buckling curve; the physiological parameter sensor is connected with the microprocessor of the acquisition processing circuit through a buckling curve.
3. The flexible fingerstall for collecting surface myoelectricity and multiple physiological parameters according to claim 1, wherein the transparent isolation layer film is formed by spin-coating Polydimethylsiloxane (PDMS) on the outer surface of the flexible fingerstall substrate on which the collection processing circuit is adhered, and redundant PDMS is removed at each myoelectricity collection electrode to expose the myoelectricity collection electrode.
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