CN110333343A - A kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling - Google Patents
A kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling Download PDFInfo
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- CN110333343A CN110333343A CN201910697659.XA CN201910697659A CN110333343A CN 110333343 A CN110333343 A CN 110333343A CN 201910697659 A CN201910697659 A CN 201910697659A CN 110333343 A CN110333343 A CN 110333343A
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- exhaling
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- 238000001514 detection method Methods 0.000 title claims abstract description 17
- 238000013139 quantization Methods 0.000 title claims abstract description 13
- 238000005070 sampling Methods 0.000 claims abstract description 50
- 238000012544 monitoring process Methods 0.000 claims abstract description 36
- 238000012360 testing method Methods 0.000 claims abstract description 28
- 239000008103 glucose Substances 0.000 claims abstract description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 20
- 238000011156 evaluation Methods 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000005259 measurement Methods 0.000 claims abstract description 10
- 239000002253 acid Substances 0.000 claims description 11
- 150000007513 acids Chemical class 0.000 claims description 11
- 150000001298 alcohols Chemical class 0.000 claims description 11
- 238000005086 pumping Methods 0.000 claims description 6
- 210000002784 stomach Anatomy 0.000 claims description 5
- 230000035945 sensitivity Effects 0.000 claims description 4
- 230000003595 spectral effect Effects 0.000 claims description 4
- 206010070834 Sensitisation Diseases 0.000 claims description 3
- 238000001819 mass spectrum Methods 0.000 claims description 3
- 230000008313 sensitization Effects 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 239000008280 blood Substances 0.000 abstract description 20
- 210000004369 blood Anatomy 0.000 abstract description 20
- 238000005516 engineering process Methods 0.000 abstract description 5
- 239000004615 ingredient Substances 0.000 abstract 1
- 238000001467 acupuncture Methods 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 208000002705 Glucose Intolerance Diseases 0.000 description 2
- 201000009104 prediabetes syndrome Diseases 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- 238000000262 chemical ionisation mass spectrometry Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 238000001184 proton transfer reaction mass spectrometry Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Abstract
The present invention relates to a kind of sugared tolerances based on detection of exhaling to quantify evaluating apparatus, including sampling pump, sampling pipe, gas sensing unit, monitoring unit, display unit and power supply unit；The present invention be by breath detection device to before and after intake glucose expiration ingredient and concentration be monitored, realize the quantization evaluation and test of sugared tolerance, the invasive method of blood drawing measurement blood glucose can be replaced.The technology of the present invention method has many advantages, such as noninvasive, acceptance is high, hygienic, convenient.
Description
Technical field
The present invention relates to the technical fields such as sensor technology, biomedical engineering, health care, and in particular to one kind is based on
The sugared tolerance detected of exhaling quantifies evaluating apparatus.
Background technique
Carbohydrate tolerance test is to differentiate a kind of common method of sugared tolerance, is the standard method of diabetes diagnosis.In sugar
In tolerance test, subject's early morning empty stomach venous blood collection measures blood sugar concentration, 75 grams of glucose is then once taken, after clothes are sugared
0.5, each survey blood glucose is primary within 1,2 hour (when necessary can be at 3 hours), and the time to measure blood glucose is abscissa (on an empty stomach for 0
When), blood sugar concentration is ordinate, draws glucose tolerance curve, and normal person is peaked after taking sugar, then gradually dropped for 0.5-1 hours
Low, generally in 2 hours or so recovery normal values, subject's fasting blood-glucose of sugared tolerance difference is higher than normal value, blood after clothes sugar
Sugared concentration sharply increases, and can still be higher than after 2 hours normal.When can be seen that carbohydrate tolerance test from test process, need repeatedly to prick
Needle takes blood to measure blood glucose, although it is a kind of Micro-operation that acupuncture treatment, which takes blood, psychologically has in face of repeatedly acupuncture treatment, most people
A degree of fear sense.
Summary of the invention
Technology of the invention solves the problems, such as: asking for acupuncture treatment blood drawing must be repeated several times by overcoming in existing sugared tolerance test
Topic provides a kind of sugared tolerance based on detection of exhaling and quantifies evaluating apparatus, realize without blood drawing can noninvasive evaluation and test it is sugared resistance to
By ability.
The technology of the present invention solution: a kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling, including sampling
Pump 1, sampling pipe 2, gas sensing unit 3, monitoring unit 4, display unit 5 and power supply unit 6；The sampling pump 1 and sampling
Pipe 2 is connected；The gas sensing unit 3 is connected with sampling pipe 2, can directly contact measurement or non-connect with gas in sampling pipe 2
Touching measurement；The monitoring unit 4 is connected with gas sensing unit 3, and is connected with display unit 5 and sampling pump 1；The power supply
Unit 6 is connected with sampling pump 1, monitoring unit 4, display unit 5.
The gas sensing unit 3 is the component of alcohols and acids sensitivity, can be the minute sense of gas sensitization
Device or sensor array are also possible to spectral class and mass spectrum class large size sensor apparatus.
The power supply unit 6 is battery or mains supply.
The monitoring unit 4 in the time domain it is accurate control and synchronized sampling pump 1, sampling pipe 2, gas sensing unit 3,
Display unit 5 and power supply unit 6 realize sugared tolerance quantization evaluation and test, and detailed process is as follows:
A, detect expiration before taking in glucose: power supply unit 6 is powered to sampling pump 1, monitoring unit 4, display unit 5, is adopted
Sample pumps 1 and starts pumping under the control of monitoring unit 4, and testee is allowed to keep that on an empty stomach, the subject before intake glucose being exhaled
Gas is pumped into sampling pipe 2, and gas sensing unit 3 detects alcohols and acids gas concentration C in exhaling in sampling pipe 20, will measure
Data are conveyed to the storage of monitoring unit 4；
B, detect expiration after taking in glucose: power supply unit 6 is powered to sampling pump 1, monitoring unit 4, display unit 5, is adopted
Sample pump 1 starts pumping under the control of monitoring unit 4, exhales after allowing the sugared resistance test person after oral glucose 75g to wait 2 hours
Gas out, expiration are pumped in sampling pipe 2, and gas sensing unit 3 detects the alcohols in exhaling in sampling pipe 2 and acids gas is dense
Spend C2h, data measured is conveyed to monitoring unit 4 and is stored；
C, sugared tolerance quantization evaluation and test: monitoring unit 4 is according to the C of storage0And C2hCalculate to obtain evaluation and test factor K (K=C2h/
C0), it according to actual quantization evaluation and test needs that K value can be divided into three sections, such as: 0≤K < A, A≤K < B, B < K, A, which are that sugar is resistance to, to be tested just
Normal limit value, B are diabetes limit value, are impaired glucose tolerance between A and B.Monitoring unit 4 is according to evaluation and test factor K value and limit value A and B
It is compared, evaluation result is delivered to display unit 5.
Present invention difference compared with prior art and advantage are:
(1) carbohydrate tolerance test is to understand the standard method of sugared tolerance, but need during carbohydrate tolerance test at present
Repeatedly acupuncture treatment blood drawing detection blood glucose.The technology of the present invention realizes sugar by alcohols/acids index in breath detection device measurement expiration
The noninvasive evaluation and test of tolerance, the invasive step of alternative blood drawing measurement blood glucose.It is exhaled in the present invention by taking glucose front and back
Characteristic component measurement has essence different in gas to differentiate that the technical method of sugared tolerance surveys sugar from existing invasive blood drawing.This hair
It is bright that there is many advantages, such as noninvasive, acceptance is high, hygienic, convenient.
(2) innovation of the invention is: quantifying evaluating apparatus by a kind of sugared tolerance based on detection of exhaling
Change to monitor the characteristic components such as alcohols/acids in expiration, substitutes the invasive process of conventional blood drawing survey blood glucose, realization is exhaled noninvasive
Sugared tolerance is evaluated and tested in quantization, provides a kind of new tool for sugared tolerance quantization evaluation and test.
Detailed description of the invention
Fig. 1 is that a kind of sugared tolerance based on detection of exhaling of the invention quantifies evaluating apparatus schematic diagram.
Specific embodiment
As shown in Figure 1, a kind of sugared tolerance based on detection of exhaling quantifies evaluating apparatus, including sampling pump 1, sampling pipe
2, gas sensing unit 3, monitoring unit 4, display unit 5 and power supply unit 6；The sampling pump 1 is connected with sampling pipe 2；Institute
The gas sensing unit 3 stated is connected with sampling pipe 2, can direct contact measurement or non-cpntact measurement with gas in sampling pipe 2；It is described
Monitoring unit 4 is connected with gas sensing unit 3, and is connected with display unit 5 and sampling pump 1；Said supply unit 6 and sampling
Pump 1, monitoring unit 4, display unit 5 are connected.
The accurate control of monitoring unit 4 in the time domain and synchronized sampling pump 1, sampling pipe 2, gas sensing unit 3, display list
Member 5 and power supply unit 6, the process for implementing sugared tolerance quantization evaluation and test are as follows:
A, detect expiration before taking in glucose: power supply unit 6 is powered to sampling pump 1, monitoring unit 4, display unit 5, is adopted
Sample pumps 1 and starts pumping under the control of monitoring unit 4, allows testee to keep on an empty stomach, by the subject's before intake glucose
It exhales and is pumped into sampling pipe 2, gas sensing unit 3 detects alcohols and acids gas concentration C in exhaling in sampling pipe 20, will survey
It obtains data and is conveyed to the storage of monitoring unit 4；
B, detect expiration after taking in glucose: power supply unit 6 is powered to sampling pump 1, monitoring unit 4, display unit 5, is adopted
Sample pump 1 starts pumping under the control of monitoring unit 4, exhales after allowing the sugared resistance test person after oral glucose 75g to wait 2 hours
Gas out, expiration are pumped in sampling pipe 2, and gas sensing unit 3 detects the alcohols in exhaling in sampling pipe 2 and acids gas is dense
Spend C2h, data measured is conveyed to monitoring unit 4 and is stored；
C, sugared tolerance quantization evaluation and test: monitoring unit 4 is according to the C of storage0And C2hCalculate to obtain evaluation and test factor K (C2h/C0), root
It according to actual quantization evaluation and test needs that K value can be divided into three sections, such as: 0≤K < A, A≤K < B, B < K, A are the normal limit of the resistance to test of sugar
Value, B are diabetes limit value, are impaired glucose tolerance between A and B.Monitoring unit 4 is carried out according to evaluation and test factor K value and limit value A and B
Compare, evaluation result is delivered to display unit 5.According to actual verification, wherein the actual value of A may be in 1 ± 0.2 range, B
Actual value may be in 2 ± 0.4 ranges.
Gas sensing unit 3 is the component of the component either acids sensitivity of alcohols sensitivity, can be gas sensitization
Minute sense device or sensor array, be also possible to spectral class and mass spectrum class large size sensor apparatus, such as organic analyte detection
Fourier infrared spectrograph, chemical ionization mass spectrometry instrument, electron spray extraction ionization mass spectrometer, Photoionization Mass Spectrometry instrument etc., wherein chemistry
Ionization mass spectrometer include Proton transfer reaction mass spectrometry instrument, ion-molecule reaction mass spectrograph, organic matter doping auxiliary photo-ionisation matter
Spectrometer etc..When power supply unit 6 is minute sense device, power supply unit can choose battery, if power supply unit 6 is spectral class or matter
Class large size sensor apparatus is composed, then larger battery pack or mains supply may be selected.
Description of the invention does not elaborate and partly belongs to techniques well known.
The above, part specific embodiment only of the present invention, but scope of protection of the present invention is not limited thereto, appoints
In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of, should all cover by what those skilled in the art
In protection scope of the present invention.
Claims (4)
1. a kind of sugared tolerance based on detection of exhaling quantifies evaluating apparatus characterized by comprising sampling pump (1), sampling
Manage (2), gas sensing unit (3), monitoring unit (4), display unit (5) and power supply unit (6)；The sampling pump (1) with adopt
Sample pipe (2) is connected；The gas sensing unit (3) is connected with sampling pipe (2), with the direct contact measurement of sampling pipe (2) interior gas
Or non-cpntact measurement；The monitoring unit (4) is connected with gas sensing unit (3), and with display unit (5) and sampling pump (1)
It is connected；Said supply unit (6) is connected with sampling pump (1), monitoring unit (4), display unit (5).
2. a kind of sugared tolerance based on detection of exhaling according to claim 1 quantifies evaluating apparatus, it is characterised in that:
The gas sensing unit (3) is the component of alcohols and acids sensitivity or the minute sense device or sensor of gas sensitization
Array or spectral class and mass spectrum class sensor apparatus.
3. a kind of sugared tolerance based on detection of exhaling according to claim 1 quantifies evaluating apparatus, it is characterised in that:
Said supply unit (6) is battery or mains supply.
4. a kind of sugared tolerance based on detection of exhaling according to claim 1 quantifies evaluating apparatus, it is characterised in that:
The accurate control of the monitoring unit (4) in the time domain and synchronized sampling pump (1), sampling pipe (2), gas sensing unit (3), show
Show that unit (5) and power supply unit (6) realize sugared tolerance quantization evaluation and test, detailed process is as follows:
A, power supply unit (6) is to sampling pump (1), monitoring unit (4), display unit (5) power supply, and sampling pump (1) is in monitoring unit
(4) start pumping under control, the expiration after subject on an empty stomach intake glucose is pumped into sampling pipe (2), gas sensing list
Alcohols and acids gas concentration C in exhaling in first (3) detection sampling pipe (2)0, data measured is conveyed to monitoring unit (4)
Storage；
B, sampling pump (1) starts pumping under the control of monitoring unit (4), and the expiration of subject is pumped to sampling after several hours
It manages in (2), gas sensing unit (3) detects alcohols and acids gas concentration C in exhaling in sampling pipe (2)2h, by data measured
It is conveyed to monitoring unit (4) storage；
C, monitoring unit (4) is according to the C of storage0And C2hCalculate to obtain evaluation and test factor K, K=C2h/C0, monitoring unit (4) according to evaluation and test because
Sub- K value is compared and evaluates and tests with the limit value of setting, and evaluation result is delivered to display unit (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910697659.XA CN110333343A (en) | 2019-07-30 | 2019-07-30 | A kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910697659.XA CN110333343A (en) | 2019-07-30 | 2019-07-30 | A kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling |
Publications (1)
| Publication Number | Publication Date |
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| CN110333343A true CN110333343A (en) | 2019-10-15 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910697659.XA Pending CN110333343A (en) | 2019-07-30 | 2019-07-30 | A kind of sugared tolerance quantization evaluating apparatus based on detection of exhaling |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113588821A (en) * | 2021-07-29 | 2021-11-02 | 中国科学院合肥物质科学研究院 | Method for detecting and identifying oral odor |
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| US20030008407A1 (en) * | 2001-03-03 | 2003-01-09 | Fu Chi Yung | Non-invasive diagnostic and monitoring system based on odor detection |
| US20030054428A1 (en) * | 2000-05-30 | 2003-03-20 | Monfre Stephen L. | Method of screening for disorders of glucose metabolism |
| US20040137637A1 (en) * | 2003-01-13 | 2004-07-15 | Chuji Wang | Breath gas analyzer for diagnosing diabetes and method of use thereof |
| JP2011102747A (en) * | 2009-11-10 | 2011-05-26 | Kitakyushu Foundation For The Advancement Of Industry Science & Technology | Method for exhalation analysis, and exhalation analyzer |
| CN108693353A (en) * | 2018-05-08 | 2018-10-23 | 重庆大学 | A kind of long-range diabetes intelligent diagnosis system detecting breathing gas based on electronic nose |
| WO2019058021A1 (en) * | 2017-09-20 | 2019-03-28 | Halax Oy Finland | A system and a method for producing information indicative of diabetes |
| CN210427579U (en) * | 2019-07-30 | 2020-04-28 | 中国科学院合肥物质科学研究院 | Sugar tolerance quantitative evaluation device based on expiration detection |
-
2019
- 2019-07-30 CN CN201910697659.XA patent/CN110333343A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030054428A1 (en) * | 2000-05-30 | 2003-03-20 | Monfre Stephen L. | Method of screening for disorders of glucose metabolism |
| US20030008407A1 (en) * | 2001-03-03 | 2003-01-09 | Fu Chi Yung | Non-invasive diagnostic and monitoring system based on odor detection |
| US20040137637A1 (en) * | 2003-01-13 | 2004-07-15 | Chuji Wang | Breath gas analyzer for diagnosing diabetes and method of use thereof |
| JP2011102747A (en) * | 2009-11-10 | 2011-05-26 | Kitakyushu Foundation For The Advancement Of Industry Science & Technology | Method for exhalation analysis, and exhalation analyzer |
| WO2019058021A1 (en) * | 2017-09-20 | 2019-03-28 | Halax Oy Finland | A system and a method for producing information indicative of diabetes |
| CN108693353A (en) * | 2018-05-08 | 2018-10-23 | 重庆大学 | A kind of long-range diabetes intelligent diagnosis system detecting breathing gas based on electronic nose |
| CN210427579U (en) * | 2019-07-30 | 2020-04-28 | 中国科学院合肥物质科学研究院 | Sugar tolerance quantitative evaluation device based on expiration detection |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113588821A (en) * | 2021-07-29 | 2021-11-02 | 中国科学院合肥物质科学研究院 | Method for detecting and identifying oral odor |
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