CN110314281B - Epilepsy therapeutic apparatus and control method thereof - Google Patents
Epilepsy therapeutic apparatus and control method thereof Download PDFInfo
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
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- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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Abstract
The application provides an epileptic therapeutic apparatus and a control method thereof, wherein the epileptic therapeutic apparatus comprises an electroencephalogram monitoring module, a current perfusion module, an analysis and control module and a power supply module; the electroencephalogram monitoring module comprises potential detection electrodes, a voltage amplifying circuit is arranged corresponding to each potential detection electrode, and the output end of each potential detection electrode is connected with the input end of the voltage amplifying circuit; the current pouring module comprises direct current pouring devices, each direct current pouring device comprises a first electrode, a second electrode and a direct current micro-current generating device, the first electrode is connected with the positive electrode of the direct current micro-current generating device, and the second electrode is connected with the negative electrode of the direct current micro-current generating device; the output end of the voltage amplifying circuit is connected with the input end of the analysis and control module, and the output end of the analysis and control module is in control connection with the direct-current micro-current generating device; the power supply module supplies power to the electroencephalogram monitoring module, the current perfusion module and the analysis and control module. Can be used for treating epilepsy, and reducing damage of epilepsy to brain nervous system.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to an epileptic therapeutic apparatus and a control method thereof.
Background
Epilepsy is a typical and frequent central nervous system disorder, a chronic disorder of transient dysfunction of the brain caused by sudden abnormal discharge of neurons of the brain, also known as massive neuronal simultaneous excitation.
Neurons are the fundamental units that make up the structure and function of the nervous system. Diffusion and conduction of the internal excitation of neurons by means of action potentials; information exchange occurs between neurons through chemical and electrical synapses. Since the ion distribution inside and outside the cell membrane of the neuron is not uniform and the cell membrane is only permeable to K+ in a quiet state, the ion concentration difference exists inside and outside the cell, and the potential outside the cell membrane is physiologically assumed to be 0, so that a resting potential of about-65 mV to-70 mV exists inside the resting neuron. The neuronal cells only generate electric tension potential and local excitation and local reaction when receiving external weak excitatory stimulus (subthreshold stimulus), and the local excitation is insufficient to cause a large opening of NA+ ion channels on the cell membrane because the local excitation tends to exponentially decrease along with the distance, but when the received stimulus intensity makes the local excitation amplitude reach a critical value (threshold stimulus), a short and severe potential fluctuation can be caused, and the NA+ ion channels on the cell membrane can be caused to be greatly opened, at the moment, NA+ rapidly enters the cell through the ion channels, and the instant internal and external potential of the cell membrane is reversed, which is called depolarization. Depolarization represents the excitation of neurons, and the high amplitude spike generated at this time is called action potential. When action potential generated by continuous excitation of neurons rapidly waves adjacent or far-away subordinate neurons and causes excitation of a certain number of neurons in a local range, local extracellular fluid potential is greatly reduced, so that potential on other neurons which should not be excited cannot maintain resting potential, and voltage-dependent ion channels on cell membranes are forced to be opened, thus abnormal synchronous excitation of a large number of neurons is generated in a small range, and epileptic morbidity is caused.
The main methods for clinically treating epilepsy at present are anti-epileptic drug treatment and surgical excision epileptic focus treatment. The antiepileptic drugs inhibit the prominent conduction of normal neurons while inhibiting epilepsy, thereby affecting the normal functions of the brain; the epilepsy is usually treated by cutting or destroying the diseased brain region, so that the problems of easy infection of wounds, difficult recovery after operation and the like caused by general large-scale operations are solved, the functions of the corresponding brain region can be irreversibly and permanently lost by patients, and the function loss, such as memory, language ability, visual ability, sensory ability and the like, can be caused by surgical cutting or destroying of an epileptic focus in an important functional region. Thus, anti-epileptic drug therapy and surgical excision of epileptic lesions may treat epilepsy to some extent, but they may have numerous side effects.
Disclosure of Invention
The application provides an epileptic therapeutic apparatus and a control method thereof, which are used for treating epileptic diseases and reducing damage of epileptic treatment to brain nervous system.
The application provides an epileptic therapeutic apparatus, which comprises an electroencephalogram monitoring module, a current perfusion module, an analysis and control module and a power supply module; wherein,
the electroencephalogram monitoring module comprises a plurality of potential detection electrodes, the input ends of the potential detection electrodes are arranged at different epileptic foci, voltage amplification circuits are correspondingly arranged on the potential detection electrodes, and the output end of each potential detection electrode is connected with the input end of each voltage amplification circuit;
the current perfusion module comprises a plurality of direct current perfusion devices, each direct current perfusion device comprises a first electrode, a second electrode and a direct current micro-current generating device, the first electrode is connected with the positive electrode of the direct current micro-current generating device, and the second electrode is connected with the negative electrode of the direct current micro-current generating device;
the power supply module supplies power to the electroencephalogram monitoring module, the current perfusion module and the analysis and control module;
the output end of the voltage amplification circuit is connected with the input end of the analysis and control module, the analysis and control module analyzes the waveform output by the voltage amplification circuit, the output end of the analysis and control module is in control connection with the direct current micro-current generating device, when the waveform of the epileptic focus is normal, the analysis and control module controls the direct current perfusion device to output steady direct current micro-current, and when the waveform of the epileptic focus is abnormal, the analysis and control module controls the direct current perfusion device to output direct current blocking micro-current.
Optionally, in the above epileptic therapeutic apparatus, the direct current micro-current generating device includes a direct current micro-current switching circuit and at least two direct current micro-current generating circuits; the direct-current micro-current generation circuit is connected with the first electrode and the second electrode through the direct-current micro-current switching circuit; and the analysis and control module is in control connection with the direct-current micro-current switching circuit.
Optionally, in the above epileptic therapeutic apparatus, the direct current micro-current generating device includes a digital-to-analog conversion circuit and a direct current micro-current generating circuit, an analog signal output by the digital-to-analog conversion circuit is controlled and connected with the direct current micro-current generating circuit to generate direct current micro-currents with two or more magnitudes, and the analysis and control module is controlled and connected with the digital-to-analog conversion circuit.
Optionally, in the epileptic therapeutic apparatus, the direct current micro-current generating circuit includes a first direct current micro-current generating circuit and a second direct current micro-current generating circuit.
Optionally, in the epileptic therapeutic apparatus, the direct current micro-current generating circuit is a constant current source circuit, a direct current sine wave generating circuit or a direct current square wave generating circuit.
Optionally, in the above epileptic therapeutic apparatus, once the waveform of any epileptic focus is abnormal, the analysis and control module controls the direct current perfusion device to output direct current blocking micro current.
Based on the epileptic therapeutic apparatus provided herein, the present application further provides a method for controlling an epileptic therapeutic apparatus, the method comprising:
controlling the direct current perfusion device to output steady direct current micro current;
acquiring an electroencephalogram signal detected by an electroencephalogram monitoring module and analyzing the electroencephalogram signal;
when the electroencephalogram signals find epileptic waveforms, the direct current perfusion device is controlled to switch from outputting steady direct current micro-currents to outputting direct current blocking micro-currents;
and controlling the direct current perfusion device to switch from the output direct current blocking micro current to the stable direct current micro current according to the set direct current blocking micro current duration.
Optionally, in the above epileptic therapeutic apparatus control method, controlling the direct current perfusion device to switch from outputting steady direct current micro-current to outputting direct current blocking micro-current includes:
and controlling the direct-current micro-current switching circuit, and selecting the direct-current micro-current generating circuit to output direct-current blocking micro-current.
Optionally, in the above epileptic therapeutic apparatus control method, controlling a direct current microcurrent switching circuit, selecting the direct current microcurrent generating circuit to output a direct current blocking microcurrent includes:
and controlling the direct-current micro-current switching circuit to switch and select the first direct-current micro-current generating circuit or the second direct-current micro-current generating circuit.
Optionally, in the above epileptic therapeutic apparatus control method, controlling the direct current perfusion device to switch from outputting steady direct current micro-current to outputting direct current blocking micro-current includes:
the analog signal output by the digital-to-analog conversion circuit is controlled to be switched, and the direct current micro-current generation circuit is selected to output direct current blocking micro-current.
The epilepsy therapeutic apparatus provided by the application and the control method thereof adopt a direct current perfusion device in a direct current perfusion module to perfuse direct current micro-current at an epileptic focus. Specifically, the direct current perfusion device outputs direct current microcurrent through the direct current microcurrent generating device, and the direct current microcurrent acts on an epileptic focus through the first electrode and the second electrode, so that the treatment of epileptic diseases is realized. The brain electrical monitoring module detects brain electrical signals, the analysis and control module analyzes the detected brain electrical signals, when abnormal epileptic signals are detected, waveform of an epileptic focus is abnormal, the direct current microcurrent generating device is controlled to adjust the output direct current microcurrent, the ion distribution of all epileptic focuses is controlled, relatively large current is poured, and when the set duration of direct current blocking microcurrent is up, the direct current microcurrent generating device is controlled to restore the output of the original direct current microcurrent.
When no abnormal epileptic signal is detected, the direct-current microcurrent generating device can always output a direct-current microcurrent for adjusting the ion distribution at an epileptic focus so as to realize the long-term stable treatment of the direct-current microcurrent; when abnormal epileptic signals are detected, the direct current microcurrent generating device is adjusted to increase the output direct current microcurrent, so that short-term direct current blocking microcurrent treatment is realized, and the phenomenon that a great amount of ions flow in the cell due to neuron excitation so as to cause the electric field of extracellular fluid to be changed, thereby synchronously exciting the neurons and finally causing the generation of epileptic is avoided. The utility model provides an epileptic therapeutic apparatus, through long-term firm direct current microcurrent treatment and short-term direct current blocking microcurrent treatment combination, the seizure that suppresses epileptic that can be better promotes the treatment of epileptic disease, and need not to destroy brain inner structure, also have universality to the patient of epileptic focus location in important functional area.
Drawings
In order to more clearly illustrate the technical solutions of the present application, the drawings that are needed in the embodiments will be briefly described below, and it will be obvious to those skilled in the art that other drawings can be obtained from these drawings without inventive effort.
Fig. 1 is a block diagram of an epileptic therapeutic apparatus provided in an embodiment of the present application;
FIG. 2 is a schematic diagram of a voltage analysis and control circuit according to an embodiment of the present disclosure;
FIG. 3 is a schematic diagram of another voltage analysis and control circuit according to an embodiment of the present disclosure;
fig. 4 is a schematic structural diagram of a direct current perfusion apparatus according to an embodiment of the present disclosure;
fig. 5 is a flowchart of a method for controlling an epileptic therapeutic apparatus according to an embodiment of the present application.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Fig. 1 shows a basic structure of an epileptic therapeutic apparatus provided in an embodiment of the present application. As shown in fig. 1, the epileptic therapeutic apparatus provided in the embodiment of the present application includes an electroencephalogram monitoring module 1, a current perfusion module 2, an analysis and control module 3, and a power module 4. The electroencephalogram monitoring module 1 comprises one or more potential detection electrodes 11, wherein a voltage amplifying circuit 12 is arranged corresponding to each potential detection electrode 11, and the output end of each potential detection electrode 11 is connected with the input end of each voltage amplifying circuit 12;
the current filling module 2 comprises one or more direct current filling devices, each direct current filling device comprises a first electrode 21, a second electrode 22 and a direct current micro-current generating device 23, the first electrode 21 is connected with the positive electrode of the direct current micro-current generating device 23, and the second electrode 22 is connected with the negative electrode of the direct current micro-current generating device 23.
The output end of the voltage amplifying circuit 12 is connected with the input end of the analysis and control module 3, and the output end of the analysis and control module 3 is in control connection with the direct current micro-current generating device 23.
The power supply module 4 supplies power to the electroencephalogram monitoring module 1, the current perfusion module 2 and the analysis and control module 3. The power supply module 4 includes a power supply circuit for supplying operating power to the respective unit circuits.
The potential detecting electrode 11 is made of a material with high conductivity, good stability and biocompatibility, and is used for detecting brain electrical signals, such as silver materials or platinum iridium alloy, insulation and connecting wires. In use, the potential detection electrode 11 is typically disposed in the vicinity of an epileptic focus for detecting brain electrical signals around neurons in the vicinity of the epileptic focus. The number of the potential detecting electrodes 11 is not particularly limited, and may be selected according to the number of epileptic foci during epileptic treatment.
The voltage amplifying circuit 12 may be a commercially available amplifying circuit, such as a single-conductor or multi-conductor physiological amplifier of Beijing Xintuo company, which can amplify an electric signal of millivolts or microvolts by tens of thousands or hundreds of thousands of times. The input end of the voltage amplifying circuit 12 is connected with the potential detection electrode 11, and the output end is connected with the input end of the analysis and control module 3. The potential detecting electrode 11 transmits the detected brain electrical signal to the voltage amplifying circuit 12, and the voltage amplifying circuit 12 performs voltage amplifying processing on the brain electrical signal detected by the potential detecting electrode 11 for analysis by the analysis and control module 3.
The first electrode 21 and the second electrode 22 are also made of materials with high conductivity, good stability and biocompatibility, and are used for injecting current into an epileptic focus, for example, silver materials or platinum iridium alloy with additional insulation and connecting wires. The first electrode 21 is placed at the cortex of the brain of an epileptic focus, the second electrode 22 is usually placed at a deeper part of the brain with less neuron distribution or near glial cells, the direct-current microcurrent generating device 23 is used for generating direct-current microcurrent, and the first electrode 21 and the second electrode 22 are used for transmitting the direct-current microcurrent generated by the direct-current microcurrent generating device 23 and forming an electrified loop. In the specific embodiment of the application, the current generated by the direct current micro-current generating device 23 flows into the epileptic focus through the first electrode 21, flows out through the second electrode 22, and finally returns to the direct current micro-current generating device 23, so as to realize continuous current filling at the epileptic focus.
The dc micro-current generating device 23 is configured to output a dc micro-current, and the dc micro-current generating device 23 generates the dc micro-current when the power module 4 supplies power to the current injection module. The direct current micro-current generating device 23 comprises a plurality of direct current micro-current generating circuits, and the direct current micro-current generating circuits are electrified to output direct current micro-currents, and can be selected from constant current source micro-currents, direct current positive-brown wave micro-currents or direct current square wave current generating circuits.
The direct current microcurrent generating device 23 can generate steady direct current microcurrent and direct current blocking microcurrent, the steady direct current microcurrent is used for stabilizing ion distribution near an epileptic focus, and meanwhile has small influence on normal brain functions, and the larger direct current blocking microcurrent is used for blocking abnormal excitation loops in the brain, so that abnormal excitation of a large number of neurons can be avoided. In general, the dc blocking microcurrents are larger than the steady dc microcurrents. In normal times, relatively fixed ion distribution exists between the two electrodes, so that more positive ions such as Na+ are distributed near an epileptic focus; when the brain electrical monitoring module of any epileptic focus monitors abnormal epileptic signals, the direct current output by the direct current perfusion device is increased, so that the phenomenon that the extracellular fluid electric field is changed due to the fact that a large amount of ions flow in due to the excitation of neurons is avoided, the neurons are excited synchronously, and finally the epilepsia is caused. Preferably, once the waveform of any epileptic focus is abnormal, the analysis and control module 3 controls the direct current perfusion device to output direct current blocking micro-current.
The number of the direct current perfusion devices can be selected according to the number of epileptic foci in the epileptic treatment process, and the application is not particularly limited. Typically, each direct current perfusion device is provided with a direct current micro-current generating device 23 and a first electrode 21 and a second electrode 22.
The analysis and control module 3 can be realized by using the existing electronic component collocation, and can also realize the functions by adopting a microcomputer circuit. Fig. 2 is a circuit configuration diagram of the analysis and control module 3 implemented by using a conventional electronic component arrangement, and fig. 3 is a circuit configuration diagram of the analysis and control module 3 implemented by using a microcomputer circuit.
When the analysis and control module 3 is implemented by adopting the existing electronic component collocation, as shown in fig. 2, the integrated schmitt trigger, the NOT gate 1, the NOT gate 2, the capacitor C, the voltage control switch, the resistor and the integrated circuit timer (NE 555) are formed, and the voltage control switch is formed by switches K1, K2 and K3 and corresponding relays M1, M2 and M3. The integrated schmitt trigger can adopt a CD4093, the function of the integrated schmitt trigger is to realize voltage comparison, when the voltage is in a certain range, low voltage is output, otherwise, high voltage is output, the NOT gate 1 realizes voltage turnover, the capacitor C, the resistor R and the integrated circuit timer (NE 555) form a monostable circuit to realize timing, and the monostable circuit needs negative pulse triggering, so that the NOT gate 2 realizes voltage V0 turnover. When the analysis and control module 3 is implemented by adopting a microcomputer circuit, as shown in fig. 3, the singlechip runs specific software to complete the work of voltage analysis and control, and the control of the direct-current micro-current generating device is realized. Details are shown in fig. 2 and 3, and will not be repeated here.
The epileptic therapeutic apparatus provided by the application adopts the direct current perfusion device in the direct current perfusion module to perfuse the direct current micro current at the epileptic focus. Specifically, the direct current perfusion device outputs direct current micro-current through the direct current micro-current generating device 23, and the direct current micro-current acts on an epileptic focus through the first electrode 21 and the second electrode 22, so that the treatment of epileptic diseases is realized. The brain electricity monitoring module 1 detects brain electricity signals, the analysis and control module 3 analyzes the detected brain electricity signals, when abnormal epileptic signals are detected, the direct current microcurrent generating device 23 is controlled to adjust the output direct current microcurrent, the ion distribution of all epileptic stoves is controlled, relatively large current is poured, and when the set duration of direct current blocking microcurrent is up, the direct current microcurrent generating device 23 is controlled to restore the output of the original direct current microcurrent. When no abnormal epileptic signal is detected, the direct-current microcurrent generating device 23 can always output a direct-current microcurrent for adjusting the ion distribution at an epileptic focus so as to realize the long-term stable treatment of the direct-current microcurrent; when abnormal epileptic signals are detected, the direct current microcurrent generating device 23 is adjusted to increase the output direct current microcurrent, so that short-term direct current blocking microcurrent treatment is realized, and the phenomenon that the extracellular fluid electric field is changed due to the fact that a large amount of ions flow in due to neuron excitation is avoided, so that neurons are excited synchronously, and finally epileptic is caused. The utility model provides an epileptic therapeutic apparatus, through long-term firm direct current microcurrent treatment and short-term direct current blocking microcurrent treatment combination, can reduce the influence of therapeutic apparatus to normal brain function, the seizure that inhibits epileptic that again can be better promotes epileptic disease's treatment, and need not to destroy brain inner structure, also has universality to the patient of epileptic kitchen location in important functional area.
In the specific embodiment of the present application, the dc micro-current generating device 23 includes a dc micro-current switching circuit and at least two dc micro-current generating circuits, where the dc micro-current generating circuits are connected to the first electrode and the second electrode through the dc micro-current switching circuit; the analysis and control module 3 is in control connection with the direct-current micro-current switching circuit.
The direct-current micro-current generating circuit is used for generating direct-current micro-current, and the direct-current micro-current switching circuit is used for selecting the direct-current micro-current generating circuit according to the output command of the analysis and control module 3, so that the switching adjustment of the direct-current micro-current is realized. For example, the dc micro-current generating circuit includes a first dc micro-current generating circuit for outputting a steady dc micro-current and a second dc micro-current generating circuit for outputting a dc blocking micro-current. Fig. 4 is a schematic structural diagram of a direct current perfusion apparatus according to an embodiment of the present application. As shown in fig. 4, the analysis and control module 3 performs selection of the first direct-current micro-current generating circuit and the second direct-current micro-current generating circuit by controlling the switching direct-current micro-current switching circuit, so as to realize switching between stable direct-current micro-current and direct-current blocking micro-current. The dc microcurrent generating circuits are not limited to the above examples, and the number of dc microcurrent generating circuits may be selected and the magnitude of the microcurrent may be determined according to the magnitude of the desired dc microcurrent and the actual use requirements.
The dc micro-current generating device 23 may also include a digital-to-analog conversion circuit and a dc micro-current generating circuit, where an analog signal output by the digital-to-analog conversion circuit is controlled and connected to the dc micro-current generating circuit to generate two or more dc micro-currents with different magnitudes, and the analysis and control module is controlled and connected to the digital-to-analog conversion circuit. The DC micro-current generating circuit outputs corresponding DC micro-current according to the received analog signal output by the digital-to-analog conversion circuit, the analysis and control module gives an analog signal output command to the digital-to-analog conversion circuit, and the analysis and control module controls the digital-to-analog conversion circuit to control the magnitude of the DC micro-current.
The direct current micro-current generating circuit is a constant current source circuit, a direct current sine wave generating circuit or a direct current square wave generating circuit.
Based on the epilepsy therapeutic apparatus provided in the embodiment of the present application, the embodiment of the present application further provides a method for controlling an epilepsy therapeutic apparatus, as shown in fig. 5, the method includes:
controlling the direct current perfusion device to output steady direct current micro current;
acquiring an electroencephalogram signal detected by an electroencephalogram monitoring module and analyzing the electroencephalogram signal;
when the electroencephalogram signals find epileptic waveforms, the direct current perfusion device is controlled to switch from outputting steady direct current micro-currents to outputting direct current blocking micro-currents;
and controlling the direct current perfusion device to switch from the output direct current blocking micro current to the stable direct current micro current according to the set direct current blocking micro current duration.
Furthermore, in the method for controlling an epileptic therapeutic apparatus provided in the embodiment of the present application, controlling the direct current perfusion device to switch from outputting steady direct current micro-current to outputting direct current blocking micro-current includes:
the analog signal output by the digital-to-analog conversion circuit is controlled to be switched, and the direct current micro-current generation circuit is controlled to output direct current blocking micro-current. Further, in the method for controlling an epileptic therapeutic apparatus provided in the embodiment of the present application, controlling the direct current perfusion device to switch from outputting steady direct current micro-current to outputting direct current blocking micro-current includes:
and controlling the direct-current micro-current switching circuit, and selecting the direct-current micro-current generating circuit to output direct-current blocking micro-current.
Furthermore, in the method for controlling an epileptic therapeutic apparatus provided in the embodiment of the present application, controlling a dc microcurrent switching circuit, selecting a dc microcurrent generating circuit to output a dc blocking microcurrent includes:
and controlling the direct-current micro-current switching circuit to switch and select the first direct-current micro-current generating circuit or the second direct-current micro-current generating circuit.
In the present specification, each embodiment is described in a progressive manner, and the same and similar parts of each embodiment are referred to each other, and each embodiment mainly describes differences from other embodiments, and relevant parts refer to part descriptions of method embodiments. Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention herein. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.
It is to be understood that the present application is not limited to the precise arrangements and instrumentalities shown in the drawings, which have been described above, and that various modifications and changes may be effected without departing from the scope thereof. The scope of the application is limited only by the appended claims.
Claims (10)
1. The epileptic therapeutic apparatus is characterized by comprising an electroencephalogram monitoring module, a current perfusion module, an analysis and control module and a power supply module; wherein,
the electroencephalogram monitoring module comprises a plurality of potential detection electrodes, the input ends of the potential detection electrodes are arranged at different epileptic foci, voltage amplification circuits are correspondingly arranged on the potential detection electrodes, and the output end of each potential detection electrode is connected with the input end of each voltage amplification circuit;
the current perfusion module comprises a plurality of direct current perfusion devices, each direct current perfusion device comprises a first electrode, a second electrode and a direct current micro-current generating device, the first electrode is connected with the positive electrode of the direct current micro-current generating device, and the second electrode is connected with the negative electrode of the direct current micro-current generating device;
the power supply module supplies power to the electroencephalogram monitoring module, the current perfusion module and the analysis and control module;
the output end of the voltage amplification circuit is connected with the input end of the analysis and control module, the analysis and control module analyzes the waveform output by the voltage amplification circuit, the output end of the analysis and control module is in control connection with the direct current micro-current generating device, when the waveform of the epileptic focus is normal, the analysis and control module controls the direct current perfusion device to output steady direct current micro-current for adjusting ion distribution at the epileptic focus to realize long-term steady direct current micro-current treatment, and when the waveform of the epileptic focus is abnormal, the analysis and control module controls the direct current perfusion device to output direct current blocking micro-current.
2. The epileptic therapeutic apparatus of claim 1, wherein said dc microcurrent generating means comprises a dc microcurrent switching circuit and at least two dc microcurrent generating circuits; the direct-current micro-current generation circuit is connected with the first electrode and the second electrode through the direct-current micro-current switching circuit; and the analysis and control module is in control connection with the direct-current micro-current switching circuit.
3. The epilepsy therapeutic apparatus according to claim 1, wherein the dc microcurrent generating device comprises a digital-to-analog conversion circuit and a dc microcurrent generating circuit, the analog signal output by the digital-to-analog conversion circuit is controlled to be connected with the dc microcurrent generating circuit to generate two or more magnitudes of dc microcurrents, and the analysis and control module is controlled to be connected with the digital-to-analog conversion circuit.
4. The epileptic therapeutic apparatus of claim 2, wherein the dc microcurrent generation circuit includes a first dc microcurrent generation circuit and a second dc microcurrent generation circuit.
5. The apparatus according to claim 2, wherein the direct current microcurrent generating circuit is a constant current source circuit, a direct current sine wave generating circuit or a direct current square wave generating circuit.
6. The epileptic therapeutic apparatus according to claim 2, wherein said analysis and control module controls said dc perfusion device to output a dc blocking microcurrent upon an abnormality in the waveform of any epileptic focus.
7. A method of controlling an epileptic therapeutic apparatus, said method comprising:
the direct current perfusion device is controlled to output steady direct current micro-current for adjusting ion distribution at an epileptic focus to realize long-term steady direct current micro-current treatment;
acquiring an electroencephalogram signal detected by an electroencephalogram monitoring module and analyzing the electroencephalogram signal;
when the electroencephalogram signals find epileptic waveforms, the direct current perfusion device is controlled to switch from outputting steady direct current micro-currents to outputting direct current blocking micro-currents;
and controlling the direct current perfusion device to switch from the output direct current blocking micro current to the stable direct current micro current according to the set direct current blocking micro current duration.
8. The method of claim 7, wherein controlling the direct current perfusion device to switch from outputting a steady direct current micro-current to outputting a direct current blocking micro-current comprises:
and controlling the direct-current micro-current switching circuit, and selecting the direct-current micro-current generating circuit to output direct-current blocking micro-current.
9. The method according to claim 8, wherein controlling the dc microcurrent switching circuit to select the dc microcurrent generating circuit to output the dc blocking microcurrent comprises:
and controlling the direct-current micro-current switching circuit to switch and select the first direct-current micro-current generating circuit or the second direct-current micro-current generating circuit.
10. The method of claim 9, wherein controlling the direct current perfusion device to switch from outputting a steady direct current micro-current to outputting a direct current blocking micro-current comprises:
the analog signal output by the digital-to-analog conversion circuit is controlled to be switched, and the direct current micro-current generation circuit is controlled to output direct current blocking micro-current.
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| CN101947357A (en) * | 2010-10-18 | 2011-01-19 | 刘辉 | Device for treating epilepsia |
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| CN106618562A (en) * | 2017-01-11 | 2017-05-10 | 南京航空航天大学 | Wearable epilepsy brain-electricity seizure brain area positioning device and method |
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| US9248302B2 (en) * | 2013-06-17 | 2016-02-02 | Adi Mashiach | Residual signal feedback-based control of an implant |
| AU2017315473B2 (en) * | 2016-08-26 | 2022-09-29 | Spr Therapeutics, Inc. | Devices and methods for delivery of electrical current for pain relief |
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| CN101947357A (en) * | 2010-10-18 | 2011-01-19 | 刘辉 | Device for treating epilepsia |
| WO2015112530A1 (en) * | 2014-01-21 | 2015-07-30 | Cerephex Corporation | Methods and apparatus for electrical stimulation |
| CN106618562A (en) * | 2017-01-11 | 2017-05-10 | 南京航空航天大学 | Wearable epilepsy brain-electricity seizure brain area positioning device and method |
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