CN110252434A - A kind of fluid storage structure and micro-fluidic chip for micro-fluidic chip - Google Patents
A kind of fluid storage structure and micro-fluidic chip for micro-fluidic chip Download PDFInfo
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- CN110252434A CN110252434A CN201910566929.3A CN201910566929A CN110252434A CN 110252434 A CN110252434 A CN 110252434A CN 201910566929 A CN201910566929 A CN 201910566929A CN 110252434 A CN110252434 A CN 110252434A
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- liquid
- micro
- fluidic chip
- cavity
- channel
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
Abstract
The present invention is suitable for micro-fluidic chip electrochemiluminescent immunoassay detection technique field, a kind of fluid storage structure and micro-fluidic chip for micro-fluidic chip is provided, the storage organization includes cavity, and the first opening is provided at the top of the cavity, and side is provided with the second opening；The liquid capsule of storage liquid is provided in the cavity；Second opening is connected with channel；It is provided in the channel and punctures part, when external force squeezes, the liquid capsule is punctured the liquid capsule by the part that punctures.The present invention passes through the liquid capsule setting that will store liquid in cavity, effectively liquid can be saved, liquid is avoided to contact with cavity or other component, there can be a possibility that reducing liquid degeneration, the stabilization of liquid properties is improved, so as to effectively improve the accuracy of micro-fluidic chip detection；In use, liquid capsule is punctured by puncturing part, so that liquid flows out, and flow to channel from the second opening, it is simple and convenient.
Description
Technical field
The invention belongs to micro-fluidic chip electrochemiluminescent immunoassay detection technique fields more particularly to a kind of for micro-fluidic chip
Fluid storage structure and micro-fluidic chip.
Background technique
Currently, there are mainly two types of development trends for in-vitro diagnosis (IVD): one is automations, integrated integration, i.e., using big
Full-automatic, the highly sensitive large-scale instrument and equipment of matched central laboratory, type hospital realizes that high-precision diseases analysis is examined
Disconnected, the reagent of use is big packaging reagent, for multiple sample analysis；Another kind miniaturization, bed sideization analyzer, using list
Person-portion packs reagent, realizes the quick analyzing and diagnosing in scene.
Small hospital or community hospital's insufficient funds, sample size are few, are not appropriate for the large scale equipment of purchasing price valuableness, and
The sample for needing to analyze is few, and packs greatly after reagent is sealed off using limited time, leads to the expired waste of reagent.And point minimized
Analyzer can solve that small hospital or community hospital's large scale equipment are at high cost, reagent waste ask using single packaged reagent
Topic.
Micro-fluidic chip is also known as chip lab (Lab-on-a-chip), refers to fields such as biology, chemistry and medicine
Involved in the basic operation units such as sample preparation, reaction, separation, detection be integrated into one piece with micro-meter scale microchannel
On chip, it is automatically performed the overall process of reaction and analysis.Based on micro-fluidic chip realize analysis and detection device the advantages of be: sample
This dosage is few, and analysis speed is fast, convenient for portable instrument is made, is highly suitable for instant, field assay.
Existing single packaged micro-fluidic chip although integrally disposed various composition, but cannot save well liquid at
Point, so that liquid parts are apt to deteriorate, test result can be made to generate deviation.
Summary of the invention
The embodiment of the present invention provides a kind of luminous micro-fluidic chip of magnetic particle, it is intended to solve the liquid of traditional microfluidic chip
The problem of ingredient cannot save very well.
The embodiments of the present invention are implemented as follows, provides a kind of fluid storage structure for micro-fluidic chip, described to deposit
Storage structure includes cavity, and the first opening is provided at the top of the cavity, and side is provided with the second opening；
The liquid capsule of storage liquid is provided in the cavity；
Second opening is connected with channel；
It is provided in the channel and punctures part, when external force squeezes, the liquid capsule is punctured the liquid capsule by the part that punctures；
First opening is provided with the elastomer for sealing first opening.
Further, the cavity bottom connects the channel.
Further, in the channel and the cavity, micro- channel structure is used at least one, micro- channel is extremely
One-dimensional less is micro-meter scale.
Further, the part that punctures includes main body and needle thorn portion, and the liquid capsule is when external force squeezes, the liquid capsule quilt
Needle thorn portion punctures.
Further, the part that punctures is provided with middle through-hole.
Further, the end in needle thorn portion is provided with runner.
The embodiment of the present invention also provides a kind of micro-fluidic chip, and the chip includes:
Substrate；
Liquid mark ligand；
The fluid storage structure on the substrate is set, and the liquid mark ligand is placed on the liquid storage
It deposits in the liquid capsule of structure.
The beneficial effects obtained by the present invention are as follows the present invention passes through the liquid capsule setting that will store liquid in cavity, Neng Gouyou
Saving to liquid for effect, avoids liquid from contacting with cavity or other component, can have a possibility that reducing liquid degeneration, mention
The stabilization of high liquid properties, so as to effectively improve the accuracy of micro-fluidic chip detection；In use, by puncturing part for liquid
Capsule punctures, so that liquid flows out, and flows to channel from the second opening, simple and convenient.
Detailed description of the invention
Fig. 1 is the partial sectional view of the luminous micro-fluidic chip of magnetic particle provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
The present invention, which passes through, will store the liquid capsule of liquid and be arranged in cavity, when detection, only liquid capsule need to be pressed to punctured part i.e.
Liquid in liquid capsule can be exported, so that liquid carries out channel.
Embodiment one
As shown in Figure 1, the embodiments of the present invention are implemented as follows, a kind of fluid storage knot for micro-fluidic chip is provided
Structure, the storage organization include cavity 11, and the first opening is provided at the top of the cavity, and side is provided with the second opening 112；
The liquid capsule 12 of storage liquid is provided in the cavity 11；
Channel 2 is connected at second opening 112；
It is provided in the channel 2 and punctures liquid capsule 12 described in part 3 when external force squeezes, the liquid capsule 12 punctures part by described
3 puncture；
First opening is provided with the elastomer 111 for sealing first opening.
Specifically, the deformable material of the elastomer 111 use elastic material or high-isolation film, specially plastics,
Rubber, aluminium foil or high-isolation film, wherein sealing material can form for same material, can also be composed for multiple material.Bullet
Property body 111 cavity 11 can be sealed to a closed space, prevent liquid capsule 12 rupture after liquid from first opening overflow.
Specifically, liquid capsule 12 can be fully seated in cavity 11,12 part of liquid capsule can also be made to stretch out from the first opening, it is exposed
In cavity 11.
The present invention passes through the setting of liquid capsule 12 that will store liquid in cavity 11, can effectively save to liquid,
It avoids liquid from contacting with cavity or other component, can have a possibility that reducing liquid degeneration, improve the stabilization of liquid properties, from
And the accuracy of micro-fluidic chip detection can be effectively improved；In use, pressing liquid capsule 12 from the first opening, become liquid capsule 12
Shape makes the contact of liquid capsule 12 puncture part 3, punctures part 3 and puncture liquid capsule 12, so that liquid flows out, and flows to from the second opening 112
Channel 2, it is simple and convenient.
Embodiment two
In an alternative embodiment of the invention, 11 bottom of cavity connects the channel 2.Liquid marked by magnetic bead ligand
It is flowed out by channel 2, channel 2 is arranged in the bottom of cavity 11, be not detained in liquid marked by magnetic bead ligand in cavity 11,
Convenient for the outflow of liquid marked by magnetic bead ligand.
Embodiment three
In an alternative embodiment of the invention, in the channel 2 and the cavity 11, micro- channel is used at least one
2 structures, at least one-dimensional micro- channel 2 is micro-meter scale.
Micro-fluidic chip of the invention will test all reagent component (sample liquid, enzyme standard configuration body, magnetic bead mark needed for process
Note ligand, cleaning solution, luminescent solution etc.) it integrates, be built into micro-fluidic chip, and designed by ingenious micro- channel 2, mating
Under the operation of instrument, realize that the operating in a key of micro-fluidic chip (only need to be can be achieved with detecting, without complicated behaviour by start button
Make), whole blood separation, immune response, cleaning separation, chemiluminescence detection are realized, so as to avoid tying in existing micro-fluidic chip
Structure design is simple, detection when it is complicated for operation the deficiencies of and defect.Serum or blood can only be carried out by also overcoming traditional chemical light-emitting appearance
The shortcomings that starching detection, and whole blood sample cannot being detected.
Example IV
In an alternative embodiment of the invention, the part 3 that punctures includes main body 31 and needle thorn portion 32, and the liquid capsule 12 exists
When external force squeezes, the liquid capsule 12 is punctured by needle thorn portion 32.Specifically, needle thorn portion 32 is in elongated pyramid type or other points
Sharp shape, and the end abutment liquid capsule 12 in needle thorn portion 32；By needle thorn portion 32, can effectively and quickly liquid capsule 12 be pierced
It is broken, convenient for the liquid outflow in liquid capsule 12.
Embodiment five
In an alternative embodiment of the invention, the part 3 that punctures is provided with middle through-hole.Through-hole in setting is convenient for liquid capsule
Liquid in 12 is flowed out along the middle through-hole, can play the role of water conservancy diversion, simple and convenient.
Embodiment six
In an alternative embodiment of the invention, the end in needle thorn portion 32 is provided with runner.Runner can be set
On the lateral wall in needle thorn portion 32, it can also be opened up since 32 end of needle thorn portion through the through-hole for puncturing part 3.Runner is set, just
It is flowed out in the liquid in liquid capsule 12 along the runner, water conservancy diversion can be played the role of, it is simple and convenient.
Embodiment seven
The embodiment of the present invention also provides a kind of micro-fluidic chip, and the chip includes:
Substrate；
Liquid mark ligand；
The fluid storage structure on the substrate is set, and the liquid mark ligand is placed on the liquid storage
It deposits in the liquid capsule of structure.
The present invention passes through the liquid capsule setting that will store liquid in cavity, can effectively save, avoid to liquid
Liquid is contacted with cavity or other component, can be had a possibility that reducing liquid degeneration, be improved the stabilization of liquid properties, so as to
Enough effectively improve the accuracy of micro-fluidic chip detection；In use, deforming liquid capsule from the first opening pressing liquid capsule, making liquid capsule
Contact punctures part, punctures part and punctures liquid capsule, so that liquid flows out, and flows to channel 2 from the second opening, simple and convenient.
Embodiment eight
In micro-fluidic chip provided in an embodiment of the present invention, liquid mark ligand includes marked by magnetic bead ligand and/or enzyme mark
Remember ligand.
The marked by magnetic bead ligand is the homogeneous magnetic standard configuration body of liquid, and the homogeneous magnetic standard configuration body of liquid includes magnetic bead, temperature
Sensitive material and solution, wherein magnetic bead includes carboxyl magnetic bead, amino magnetic bead, Streptavidin MagneSphere, antibody modification magnetic bead and resists
One of original modification magnetic bead is a variety of；Temperature-sensitive material is heat-convertible gel, includes gelatin, agar, alginate, OK a karaoke club
One of glue, hydroxymethyl cellulose, Arabic gum, guar gum, the ashamed bean gum of thorn, pectin, starch and xanthan gum are a variety of；Solution
To contain the buffer system of surfactant, protein.Due to the good fluidity of liquid, when detection, make the homogeneous magnetic mark of liquid
The sample three of ligand, enzyme tagged ligand and addition is sufficiently mixed, and can effectively improve the speed of reaction, to improve inspection
Sensitivity, repeatability and the accuracy of survey.
The enzyme tagged ligand includes the ligand of enzyme or luminous agent label.
The enzyme includes: one of horseradish peroxidase and alkaline phosphatase or a variety of；The luminous agent includes: acridine
One of ester, ABEI, fluorescent dye or fluorescent microsphere are a variety of.
Specifically, the ligand includes: one of antigen, antibody, haptens and nucleic acid or a variety of.
Enzyme or luminous agent in conjunction with analyte or compete, and form enzyme or luminous agent tagged ligand；Magnetic particle marker and analysis
Object combines or competition, forms marked by magnetic bead ligand, both described ligands may be the same or different；The magnetic enzyme tagged ligand, enzyme
Or the ligand that luminous agent tagged ligand uses includes nucleic acid, antigen, monoclonal antibody, polyclonal antibody and hormone receptor, it is described
Analyte includes DNA, small molecule (drug or drugs), antigen, antibody, hormone, antibiotic, bacterium or virus and other biochemistry marks
Will object.
In the present embodiment, the enzyme tagged ligand can be with marked by magnetic bead ligand binding (such as double antibody sandwich method) or and magnetic
Pearl tagged ligand competes (such as competition law).Wherein the ligand of the ligand of luminous agent label and enzyme label can be with marked by magnetic bead ligand
It is identical, it can also be different.Preferably, in one embodiment of the invention, two kinds of different antibodies is selected to match as enzyme label
Body and marked by magnetic bead ligand are with double antibody sandwich method detection and analysis object.In another embodiment of the invention, a kind of antigen is selected
Sample is detected with competition law respectively as enzyme tagged ligand and marked by magnetic bead ligand with a kind of antibody.
The present invention is not simple superposition magnetic microparticle chemiluminescence technology and microfluidic chip technology, but passes through hydraulic seal
Design, channel 2 design, and all chemical constituents needed for detecting are integrated, are built into micro-fluidic chip, and are actively driven with magnet
It is dynamic, one-touch magnetic microparticle chemiluminescence immune detection is realized, to realize analyte in whole blood in portable necessary instrument
Quickly, highly sensitive, accurate quantitative analysis detection.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (7)
1. a kind of fluid storage structure for micro-fluidic chip, which is characterized in that the storage organization includes cavity, the sky
The first opening is provided at the top of chamber, side is provided with the second opening；
The liquid capsule of storage liquid is provided in the cavity；
Second opening is connected with channel；
It is provided in the channel and punctures part, when external force squeezes, the liquid capsule is punctured the liquid capsule by the part that punctures；
First opening is provided with the elastomer for sealing first opening.
2. being used for the fluid storage structure of micro-fluidic chip as described in claim 1, which is characterized in that the cavity bottom connects
Connect the channel.
3. being used for the fluid storage structure of micro-fluidic chip as described in claim 1, which is characterized in that the channel and described
In cavity, micro- channel structure is used at least one, it is micro-meter scale that micro- channel is at least one-dimensional.
4. the fluid storage structure as claimed in any one of claims 1 to 3 for micro-fluidic chip, which is characterized in that described
Puncturing part includes main body and needle thorn portion, and when external force squeezes, the liquid capsule is punctured the liquid capsule by needle thorn portion.
5. being used for the fluid storage structure of micro-fluidic chip as claimed in claim 4, which is characterized in that described to puncture part setting
There is middle through-hole.
6. being used for the fluid storage structure of micro-fluidic chip as claimed in claim 4, which is characterized in that the end in needle thorn portion
Portion is provided with runner.
7. a kind of micro-fluidic chip, which is characterized in that the chip includes:
Substrate；
Liquid mark ligand；
Fluid storage structure as claimed in any one of claims 1 to 6 on the substrate, the liquid mark ligand are set
It is placed in the liquid capsule of the fluid storage structure.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910566929.3A CN110252434B (en) | 2019-06-27 | 2019-06-27 | Liquid storage structure for micro-fluidic chip and micro-fluidic chip |
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| CN201910566929.3A CN110252434B (en) | 2019-06-27 | 2019-06-27 | Liquid storage structure for micro-fluidic chip and micro-fluidic chip |
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| CN110252434B CN110252434B (en) | 2022-08-09 |
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| WO2021254323A1 (en) * | 2020-06-17 | 2021-12-23 | 京东方科技集团股份有限公司 | Device for reagent storage and release, and microfluidic device |
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