CN110231682A - A kind of photoelectric fiber-optical and production method for nervous activity regulation - Google Patents
A kind of photoelectric fiber-optical and production method for nervous activity regulation Download PDFInfo
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- CN110231682A CN110231682A CN201910385915.1A CN201910385915A CN110231682A CN 110231682 A CN110231682 A CN 110231682A CN 201910385915 A CN201910385915 A CN 201910385915A CN 110231682 A CN110231682 A CN 110231682A
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/26—Optical coupling means
- G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
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Abstract
The invention discloses a kind of photoelectric fiber-opticals, its structure is to mix photoelectric material in the end of optical fiber, it can convert light to electricity, the quantitative photocontrol that can be used for cell after electrode catheter is made, due to being for fiber optic materials, it is easily controllable and be not easy the advantages that being corroded, while having the advantages that photogene is fiber-optic illuminated and ordinary electrode.
Description
Technical field
The invention belongs to bio-photon technical fields, and more particularly relating to one kind can grind in Neuscience and neurology
Study carefully the light-operated electrode of optical fiber of field application.
Background technique
At present in Neuroscience Research field, most common nervous activity control technique has light genetic technique and electrode stimulating
Technology.Light genetic technique directly stimulates the nerve fiber or brain area for expressing photogene in advance using specialty optical fiber conveying optical signal
Domain, different nervous activities can be caused by carrying out multiple spot stimulation to light genetic nerve member different parts.Light genetic technique passes through adjusting
The signal light of different wave length, power and pulse mode can relatively easily make neuronal excitation or the inhibition of specific region, reach
To the neururgic effect of regulation.Meanwhile optical signal is accurately conveyed by optical fiber, so as to only stimulate regional area to
It avoids and other is had an impact compared with far region.The corrosion-resistant and stability that fiber optic materials itself have, ensure that probe performance
Reliably, it can be used for a long time.But the implementation of light genetic technique needs neuronal cell to express specific photosensitive protein, and photosensitive protein
It is to be realized by transfecting specific photogene.The modification transformation of neuronal genes group is not only needed using gene technology stringent
Experiment condition and consummate experimental technique, and the uncertain factors such as potential undershooting-effect also reduce transgenosis
Success rate.Further, since transgenic technology can not be applied in human body easily, therefore light genetic technique is used for human nerve reparation
With the treatment of certain neurological diseases, also considerable problem has to be solved.
Although electrode stimulating technology does not need transfection photogene can be adjusted the nervous activity of specific brain area, but
Its field distribution is extensive, often have stimulated several neurons also it is related affect it is thousands of around or even a bulk of region all
The precision of neuron, stimulation is difficult to ensure, is unable to satisfy the requirement of accuracy controlling.In addition, electrode used therein often uses metal
It is made, is implanted into the corrosion being easy in brain tissue by iuntercellular electrolyte solution, can not often be used for a long time.
Summary of the invention
The technical problem to be solved by the present invention is being mentioned aiming at the problem that existing Neural stimulation electrodes can not be used for a long time
A kind of photoelectric fiber-optical that can be used for neuromodulation electrode is supplied.
The technical scheme is that a kind of photoelectric fiber-optical for nervous activity regulation, including optical fiber, feature exist
In: optical fiber connector has light to turn Electricity Functional part, can be used for the electrode of nervous activity regulation.
It is the photoelectric material mixed in optical fiber connector that light, which turns Electricity Functional part,.
The photoelectric material is GaAs, vulcanized lead, indium antimonide, lead tin telluride, mercury cadmium telluride, the sweet phthalein of sulfuric acid three, lithium tantalate, germanium
Lead plumbate, magnesia or other optical signal can be converted into the material of electric signal by photoelectric effect or photovoltaic effect.
Light turns the PN junction that Electricity Functional part is photovoltaic semiconductors, by the Doped GaAs beryllium (p-type knot) for being deposited on optical fiber connector
It is formed with Doped GaAs tellurium (N type junction).
Cone point, flat-top tip or recessed cone point are drawn into photoelectric fiber-optical doped region heating melting.
A kind of photoelectric fiber-optical production method for nervous activity regulation: it using sedimentation wants that cone is made in optical fiber first
The region at shape tip deposits Doped GaAs beryllium and Doped GaAs tellurium respectively, forms the PN junction of photovoltaic semiconductors；Then optical fiber is made
Prefabricated rods are drawn into photoelectric fiber-optical using fiber-pulling machine.
It is once drawn into cone point in photoelectric fiber-optical doped region heating melting, cone point is exactly to be doped with GaAs
Mix the PN junction region of beryllium tellurium.
The principle of the technology of the present invention:
Photoelectric material is a kind of material that optical signal can be converted into electric signal by photoelectric effect or photovoltaic effect, works as signal
When light irradiates above-mentioned photoelectric material, will generate electric field or free charge, these electric fields or charge in surrounding materials just be will affect
Sodium on neuronal cell film, potassium-channel it is open or closed, and then regulate and control the activity of neuron.Probe shape is made in optical fiber
Shape, while these photoelectric materials are adulterated on probe tip, light-operated electrode has just been made.The light-operated electrode is pierced into experimental animal
Specific brain area, optical fiber tail portion injection specific wavelength light, when being transferred to probe tip region, so that it may excite photoelectric material
Specific electric field or charge are generated, the neururgic purpose of regulation is reached.
The technology of the present invention the utility model has the advantages that
It is to be not required to the expression of photogene, therefore side using electric field or charge stimulation neuron on this novel optical fiber electrode principle
Just simple, the experimental cost greatlyd save, and for having potential value in terms for the treatment of the certain neurological diseases of the mankind；It is this
Light-operated electrode body uses extremely fine optical fiber probe, and the electric field that photoelectric material generates can be confined near material molecule,
It thus can locally regulate and control, the neuron compared with far region can not interfered with.Fiber optic materials itself have easy to manufacture, corrosion resistant excellent
Point, thus can be used for a long time.The light-operated electrode of optical fiber of the present invention combines photoelectric material with optical fiber probe, can pass through certain wave
The light of long, power and pulse mode excitation probe position generates the electric field of some strength, carries out to peripheral neurons cell reversible
Electro photoluminescence and regulation.Have the characteristics that corrosion-resistant, easy to control, local modulation and can quantify, in Neuscience and neurology
It is had a good application prospect in research field and the treatment of certain neurological rehabilitations.It is stimulated compared to ordinary electrode, this light
Usually only several microns of probe tip of fine light-operated electrode, it is more very thin than ordinary electrode, thus to neururgic regulation in sky
Between it is upper more accurate.
Detailed description of the invention
Fig. 1 is 1 structural schematic diagram of embodiment.
Fig. 2 is 2 structural schematic diagram of embodiment.
Specific embodiment
Specific embodiments of the present invention are further described with reference to the accompanying drawing, but claimed range is not limited to
This.
Embodiment 1: a kind of light-operated electrode of photoelectric fiber-optical, the photoelectric material 2 including optical fiber probe 1 and doping.Wherein optical fiber
It is drawn using the quartz-crystal pipe in the special photoelectric material molecule of one section of region doping, the photoelectric material is GaAs, sulphur
Change lead, indium antimonide, lead tin telluride, mercury cadmium telluride, the sweet phthalein of sulfuric acid three, lithium tantalate, lead germanium oxide or magnesia etc..Manufactured special optical fiber is again
Cone is once drawn to form in the region heating melting for adulterating special photoelectric material.Just contain spy at the fiber optic probe tip of this taper
Different photoelectric material.
In use, the light of specific wavelength and power is injected from the tail portion of optical fiber probe 1, when being transmitted to probe tip, swash
The special photoelectric material 2 for sending out doping makes to generate electric field around its tip or charge, these electric fields or charge just will affect nerve
Sodium on first cell membrane, potassium-channel it is open or closed, and then regulate and control the activity of neuron.In addition it is also possible to change input
Optical signal pulse mode, generate specific regulating effect.
Embodiment 2:
(1) the light-operated electrode preparation of optical fiber
As shown in Fig. 2, fiber optic materials use pure quartz-crystal pipe (SiO2), probe position mixes gallium arsenide semiconductor material.First
Doped GaAs beryllium (p-type knot) and Doped GaAs tellurium (N are deposited in the region that optical fiber wants to be made cone point using sedimentation respectively
Type knot), form the PN junction of photovoltaic semiconductors.Then preform will be made, extraordinary light is drawn into using fiber-pulling machine
Electric light is fine.It is once drawn into cone point in the special type photoelectric fiber-optical doped region heating melting again, then cone point is exactly to mix
The miscellaneous PN junction region of Doped GaAs beryllium telluriums, here it is the light-operated electrodes of manufactured optical fiber.
(2) experimental animal prepares
Will be fixed after laboratory animal anesthesia, crown shaving preserved skin is cut with aseptic operation knife after surface sterilization and separates scalp group
It knits.It is punched with medical miniature electric drill in specific position, and the light-operated electrode insertion aperture of optical fiber is pierced into cerebral cortex.Optical fiber light
It controls electrode and embeds fixation with medical-dental cement.Be put into after experimental animal is awake dedicated culture environment take the utmost care of it is postoperative extensive
It is multiple.
(3) implement light-operated
Experimental animal is placed on animal experimental observation platform, optical fiber tail portion is connected on laser.Required power is adjusted,
Laser is opened, that is, the reaction of animal can be observed.Constantly regulate the power and pulse mode of laser, the reaction of observation experiment animal
Variation.
The embodiment of the present invention is illustrated above in conjunction with attached drawing, but the present invention is not limited to the above embodiments, it can be with
The purpose of innovation and creation according to the present invention makes a variety of variations, under the Spirit Essence and principle of all technical solutions according to the present invention
The changes, modifications, substitutions, combinations, simplifications done should be equivalent substitute mode, as long as meeting goal of the invention of the invention, only
Otherwise deviates from technical principle and inventive concept of the invention, belong to protection scope of the present invention.
Claims (7)
1. a kind of photoelectric fiber-optical for nervous activity regulation, including optical fiber, it is characterised in that: optical fiber connector has light to turn Electricity Functional
Part can be used for the electrode of nervous activity regulation.
2. the photoelectric fiber-optical for nervous activity regulation according to claim 1, it is characterised in that: light turns Electricity Functional part and is
Mix the photoelectric material in optical fiber connector.
3. the photoelectric fiber-optical for nervous activity regulation according to claim 2, it is characterised in that: the photoelectric material is arsenic
Change gallium, vulcanized lead, indium antimonide, lead tin telluride, mercury cadmium telluride, the sweet phthalein of sulfuric acid three, lithium tantalate, lead germanium oxide, magnesia or other can will
Optical signal is converted into the material of electric signal by photoelectric effect or photovoltaic effect.
4. the photoelectric fiber-optical for nervous activity regulation according to claim 2, it is characterised in that: light, which turns Electricity Functional part, is
The PN junction of photovoltaic semiconductors is made of the Doped GaAs beryllium (p-type knot) and Doped GaAs tellurium (N type junction) that are deposited on optical fiber connector.
5. the photoelectric fiber-optical for nervous activity regulation according to claim 2, it is characterised in that: in photoelectric fiber-optical doped region
Domain heating melting is drawn into cone point, flat-top tip or recessed cone point.
6. a kind of photoelectric fiber-optical production method for nervous activity regulation, it is characterised in that: first using sedimentation in optical fiber
The region for wanting to be made cone point deposits Doped GaAs beryllium and Doped GaAs tellurium respectively, forms the PN junction of photovoltaic semiconductors；So
After preform is made, be drawn into photoelectric fiber-optical using fiber-pulling machine.
7. the photoelectric fiber-optical production method for nervous activity regulation according to claim 6, it is characterised in that: in photoelectricity light
Fine doped region heating melting is drawn into cone point.
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| CN201910385915.1A CN110231682B (en) | 2019-05-09 | 2019-05-09 | Photoelectric optical fiber for regulating and controlling nerve activity and manufacturing method |
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| CN201910385915.1A CN110231682B (en) | 2019-05-09 | 2019-05-09 | Photoelectric optical fiber for regulating and controlling nerve activity and manufacturing method |
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| CN110231682B (en) | 2021-07-27 |
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