CN110201297A - A kind of absorbable microneedle patch of sulfated glycan - Google Patents
A kind of absorbable microneedle patch of sulfated glycan Download PDFInfo
- Publication number
- CN110201297A CN110201297A CN201910636261.5A CN201910636261A CN110201297A CN 110201297 A CN110201297 A CN 110201297A CN 201910636261 A CN201910636261 A CN 201910636261A CN 110201297 A CN110201297 A CN 110201297A
- Authority
- CN
- China
- Prior art keywords
- needle body
- drug target
- sulfated
- microneedle patch
- micropin needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
Abstract
The invention discloses a kind of sulfated glycans to can absorb microneedle patch, belong to a kind of medical material, it is made of the basal layer without drug target and the soluble micropin needle body containing sulfated glycan, the drug target is supported in the soluble micropin needle body, drug target can be Pentosan Polysulfate Sodium or poly-sulfated glycosaminoglycan, and soluble micropin needle body material is selected from one of polyvinylpyrrolidone, Sodium Hyaluronate, chondroitin sulfate or ammonia sugar or several.It avoids sulfated glycan injection when conventional therapy from using bring pain, patient is facilitated to use.
Description
Technical field
The present invention relates to pharmaceutical technology fields, relate particularly to a kind of absorbable microneedle patch of sulfated glycan.
Background technique
The common therapy of arthritis such as drug therapy, traditional administration mode have oral administration, subcutaneous administrations, transdermal
Patch administration etc..It is administered orally simple and convenient, but drug absorption is influenced by functions of intestines and stomach, and some drugs can generate stomach bad
Stimulation；Subcutaneous injection and transdermal patch administration belong to Transdermal delivery systems, the former breaches the obstacle of cuticula, can be accurate
Effective administration, but its maximum one the disadvantage is that pain, bacterium infection, tissue damage etc. can be generated to human body, the latter's
Advantage is convenient, painless, but is administered on the skin since it is only applied, and drug conveying is limited to cuticula, medicine
Object assimilation effect is poor.
It is microneedle cutaneous to be used as a kind of novel Transdermal delivery systems, collect subcutaneous administrations mode and transdermal patch administration
The advantages of in one, it is not only painless minimally invasive, but also drug absorption efficiency is high.In addition, micropin be administered when patient can self-administration, side
Just safety.Therefore, microneedle cutaneous technology just obtains extensive concern from appearance is started.Currently, the material of processing micropin
Main to select metal material and nonmetallic materials, nonmetallic materials are mainly the materials such as polymer, since polymer material easily adds
Work, process-cycle are short, at low cost, and have many advantages, such as biocompatibility and degradability, and polymer material micropin has become
One important research direction of cutaneous penetration technical field.
Summary of the invention
The present invention is to solve prior art problem and provide a kind of absorbable microneedle patch of sulfated glycan, uses patient
Physiological pain is avoided when medicine, it is safe and simple.
Microneedle patch of the invention is by the basal layer without drug target and the soluble micropin needle containing sulfated glycan
Body composition, the drug target are supported in the soluble micropin needle body.
It may be preferred that the drug target is Pentosan Polysulfate Sodium, the solubility micropin needle body material is Sodium Hyaluronate.
It may be preferred that the drug target has poly-sulfated glycosaminoglycan.
It may be preferred that soluble micropin needle body material is further selected from polyvinylpyrrolidone, chondroitin sulfate or ammonia sugar
One or several kinds.
Beneficial effects of the present invention:
It is administered, is avoided using pain caused by needle injection and various problems using absorbable microneedle patch mode, it is micro-
For needle tip diameter less than 60 microns, the small wound for generate site of action of size is also very small.Technical solution of the present invention
So that the administration mode for the treatment of of arthritis is painless for patients, and is also not required to medical staff's auxiliary, letter is used
It is single convenient.
Specific embodiment
Illustrate the present invention with specific embodiment below.
Embodiment 1: a kind of sulfated glycan can absorb microneedle patch by by the basal layer without drug target and containing sulphur
It is acidified the soluble micropin needle body composition of glycan, the drug target is supported in soluble micropin needle body, the drug target
For Pentosan Polysulfate Sodium, the solubility micropin needle body material is Sodium Hyaluronate.
Embodiment 2: a kind of sulfated glycan can absorb microneedle patch by by the basal layer without drug target and containing sulphur
It is acidified the soluble micropin needle body composition of glycan, the drug target is supported in soluble micropin needle body, the drug target
For poly-sulfated glycosaminoglycan, the solubility micropin needle body material is polyvinylpyrrolidone.
Embodiment 3: a kind of sulfated glycan can absorb microneedle patch by by the basal layer without drug target and containing sulphur
It is acidified the soluble micropin needle body composition of glycan, the drug target is supported in soluble micropin needle body, the drug target
For Pentosan Polysulfate Sodium and poly-sulfated glycosaminoglycan, the solubility micropin needle body material is Sodium Hyaluronate, polyvinylpyrrolidine
Ketone, chondroitin sulfate or ammonia sugar it is several.
Above embodiment, which is intended to illustrate the present invention, to be realized or use for professional and technical personnel in the field, to above-mentioned
Embodiment, which is modified, will be readily apparent to those skilled in the art, therefore the present invention includes but is not limited to
Above embodiment, it is any to meet the claims or specification description, meet with principles disclosed herein and novelty,
The method of inventive features, technique, product, fall within the scope of protection of the present invention.
Claims (4)
1. a kind of sulfated glycan can absorb microneedle patch, which is characterized in that the microneedle patch is by the base without drug target
Bottom and soluble micropin needle body composition containing sulfated glycan, the drug target is supported in soluble micropin needle body.
2. caning absorb microneedle patch by sulfated glycan described in claim 1, which is characterized in that the drug target is that wood is poly-
Sulphur sodium, the solubility micropin needle body material is Sodium Hyaluronate.
3. caning absorb microneedle patch by sulfated glycan of any of claims 1 or 2, which is characterized in that the drug target has
Poly-sulfated glycosaminoglycan.
4. caning absorb microneedle patch by sulfated glycan as claimed in claim 3, which is characterized in that the solubility micropin needle body
Material is further selected from one of polyvinylpyrrolidone, chondroitin sulfate or ammonia sugar or several.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910636261.5A CN110201297A (en) | 2019-07-15 | 2019-07-15 | A kind of absorbable microneedle patch of sulfated glycan |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910636261.5A CN110201297A (en) | 2019-07-15 | 2019-07-15 | A kind of absorbable microneedle patch of sulfated glycan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110201297A true CN110201297A (en) | 2019-09-06 |
Family
ID=67797484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910636261.5A Pending CN110201297A (en) | 2019-07-15 | 2019-07-15 | A kind of absorbable microneedle patch of sulfated glycan |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110201297A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114828849A (en) * | 2019-12-23 | 2022-07-29 | 久光制药株式会社 | Microneedle device and method for producing same |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039552A (en) * | 2016-05-30 | 2016-10-26 | 北京化工大学 | Bubble-type microneedle and preparation method therefor |
| CN107412943A (en) * | 2017-04-17 | 2017-12-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | A kind of soluble microneedle patch and preparation method thereof |
| US20180344999A1 (en) * | 2017-06-05 | 2018-12-06 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Microneedle patches for transdermal delivery |
| US20190015650A1 (en) * | 2017-07-16 | 2019-01-17 | Massachusetts Institute Of Technology | Microneedle tattoo patches and use thereof |
-
2019
- 2019-07-15 CN CN201910636261.5A patent/CN110201297A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106039552A (en) * | 2016-05-30 | 2016-10-26 | 北京化工大学 | Bubble-type microneedle and preparation method therefor |
| CN107412943A (en) * | 2017-04-17 | 2017-12-01 | 中国人民解放军军事医学科学院微生物流行病研究所 | A kind of soluble microneedle patch and preparation method thereof |
| US20180344999A1 (en) * | 2017-06-05 | 2018-12-06 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Microneedle patches for transdermal delivery |
| US20190015650A1 (en) * | 2017-07-16 | 2019-01-17 | Massachusetts Institute Of Technology | Microneedle tattoo patches and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114828849A (en) * | 2019-12-23 | 2022-07-29 | 久光制药株式会社 | Microneedle device and method for producing same |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190906 |
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| RJ01 | Rejection of invention patent application after publication |