CN110012904A - A kind of sym-closene disinfection effervescence tablet and preparation method thereof - Google Patents
A kind of sym-closene disinfection effervescence tablet and preparation method thereof Download PDFInfo
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- CN110012904A CN110012904A CN201910377865.2A CN201910377865A CN110012904A CN 110012904 A CN110012904 A CN 110012904A CN 201910377865 A CN201910377865 A CN 201910377865A CN 110012904 A CN110012904 A CN 110012904A
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- Prior art keywords
- closene
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- disinfection
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a kind of sym-closene disinfection effervescence tablet, by sym-closene, sodium bicarbonate, water soluble starch, citric acid, anhydrous sodium sulfate, sodium chloride, essence composition is simultaneously coated the reduction for reducing effective chlorine using polyvinylpyrrolidone, extends the holding time.Ingredient used in the disinfection effervescence tablet is pharmaceutical grade or the product for analyzing the same levels such as pure.The tablet can be used under natural calamity carrying out disinfection to disaster area drinking water, also can be used for field exploration, and investigation etc. carries out disinfection to water source when movable to reach capable of direct drinking.The disintegration of tablet speed is fast, and most fast 2min is all disintegrated in 250ml water.
Description
Technical field
This product is related to disinfectant field, and in particular to a kind of sym-closene disinfection effervescence tablet and preparation method thereof.
Background technique
Sym-closene (Trichloroisocyanuric acid, write a Chinese character in simplified form TCCA), chemical formula C3N3O3Cl3, slightly soluble
Yu Shui is soluble in alkaline solution and acetone soln, is the chlorinated organics of a kind of white crystalline powder or granular solids
Compound has strong chlorine pungent taste, belongs to chlorated fulminuric acid class compound.
The common chlorine-containing disinfectant of existing market is mainly based on the inorganic compounds containing chlorine such as sodium hypochlorite, postassium hypochlorite
Composition is wanted, there are certain disadvantage, summary and induction is as follows:
1. butter property is unstable, it is easy to decompose；
2. butter in sterilization process, is easy to generate disinfection by-products (disinfection in water
By-products, DBPs)；
3. butter does not have duration in sterilization process；
4. the chlorine source shifted in unit is few compared with sym-closene.
Although sym-closene is the ideal substitute of butter, it has centainly in use
Limitation:
1. itself property of sym-closene is insoluble in water, therefore uses more difficult；
2. sym-closene belongs to strong chloride, there is stronger oxidisability, therefore more difficult in material selection.
Summary of the invention
In order to solve sym-closene as difficulty existing for disinfectant substitute, the present invention will be each using effervescent technique
Raw material and auxiliary material scientific compatibility, prepare rapidly dissolvable, safe trichloroiminocyanuracid acid effervescent tablet.Bubble prepared by the present invention
It is rapidly dissolvable complete in 5 minutes in 250ml water to rise piece, can be used as pollution of waterhead caused by artificial, natural calamity and drink
The exterminating bacterium agent at water source.Sym-closene disinfection effervescence tablet compatibility provided by the invention is reasonable, disintegration is rapid, sterilizing
Effect is good, dissolution is quick, safety is good.
Concrete scheme of the invention is as follows:
A kind of sym-closene disinfection effervescence tablet, consists of the following mass percentage components:
Sym-closene 20~40%, disintegrating agent 40~55%, citric acid 5~10%, sodium sulphate 4~14%, chlorination
Sodium 0.5~1%, essence are less than 1%.
Preferably, above-mentioned sym-closene disinfection effervescence tablet, consists of the following mass percentage components:
Sym-closene 25~40%, disintegrating agent 45~55%, citric acid 5~10%, sodium sulphate 9~14%, chlorination
Sodium 0.5~1%, essence are less than 1%.
Above-mentioned disintegrating agent is made of sodium bicarbonate and water soluble starch.The quality of specific sodium bicarbonate and water soluble starch
Than for 8:1.
Another object of the present invention is to provide the preparation methods of above-mentioned sym-closene disinfection effervescence tablet, including with
Lower step:
(1) it is sieved: the processing of 80-100 mesh was carried out to each raw material；
(2) it mixes: being stirred evenly after each raw material is mixed；
(3) tabletting: the raw material after mixing is put into tablet press machine and is pelletized to obtain the final product.
Beneficial effects of the present invention:
(1) tablet prepared by is disintegrated in water and solution rate is fast, can all be dissolved in 5min in 250ml water；
(2) tablet prepared by carries out dissipation test to microorganism, and dissipation effect is obvious；
(3) tablet prepared by can be used for the exterminating bacterium of artificial pollution of waterhead and drinking water source caused by natural calamity
Agent；
(4) tablet prepared by is safe and non-toxic；
(5) the tablet convenient transportation, storage；
(6) tablet material is highly-safe, raw material is easy to get；Method for preparing tablet thereof is simple, can be mass-produced；Tablet cost
It is low, bactericidal effect is good, long shelf-life.
Detailed description of the invention
Fig. 1 is the outside drawing of sym-closene disinfection effervescence tablet prepared by the present invention.
Specific embodiment
The present invention is further described combined with specific embodiments below, and the contents of the present invention are completely without being limited thereto.
A kind of sym-closene disinfection effervescence tablet, consists of the following mass percentage components:
Sym-closene 20~40%, disintegrating agent 40~55%, citric acid 5~10%, sodium sulphate 4~14%, chlorination
Sodium 0.5~1%, essence are less than 1%.
Preferably, above-mentioned sym-closene disinfection effervescence tablet, consists of the following mass percentage components:
Sym-closene 25~40%, disintegrating agent 45~55%, citric acid 5~10%, sodium sulphate 9~14%, chlorination
Sodium 0.5~1%, essence are less than 1%.
Above-mentioned disintegrating agent is made of sodium bicarbonate and water soluble starch.The quality of specific sodium bicarbonate and water soluble starch
Than for 8:1.
Another object of the present invention is to provide the preparation methods of above-mentioned sym-closene disinfection effervescence tablet, including with
Lower step:
(1) it is sieved: the processing of 80-100 mesh was carried out to each raw material；
(2) it mixes: being stirred evenly after each raw material is mixed；
(3) tabletting: the raw material after mixing is put into tablet press machine and is pelletized to obtain the final product.
Embodiment 1
(1) each ingredient percent composition is as follows:
Wherein, disintegrating agent is sodium bicarbonate and water soluble starch, and the mass ratio of sodium bicarbonate and water soluble starch is 8:1.
(2) production method:
Each raw material is crushed, 80-100 mesh is crossed, proportionally mixes, 2g mixing powder is weighed and is put into tablet press machine
Tabletting is carried out under 15 tons of pressure, the tablet of 2g/ piece can be obtained, with the polyvinylpyrrolidone ethanol solution of certain content
It sprayed, dry to obtain finished product.
Embodiment 2
(1) each ingredient percent composition is as follows:
Wherein, disintegrating agent is sodium bicarbonate and water soluble starch, and the mass ratio of sodium bicarbonate and water soluble starch is 8:1.
(2) production method: with embodiment 1.
Embodiment 3
(1) each ingredient percent composition is as follows:
Wherein, disintegrating agent is sodium bicarbonate and water soluble starch, and the mass ratio of sodium bicarbonate and water soluble starch is 8:1.
(2) production method: with embodiment 1.
Embodiment 4
(1) each ingredient percent composition is as follows:
Wherein, disintegrating agent is sodium bicarbonate and water soluble starch, and the mass ratio of sodium bicarbonate and water soluble starch is 8:1.
(2) production method: with embodiment 1.
Embodiment 5
1. disintegration rate is tested
Test method: sym-closene disinfection effervescence tablet prepared by Examples 1 to 4 is set in 250ml water, from being put into
To being completely dissolved timing.
Test result is as follows shown in table:
The result shows that: prepared trichloroiminocyanuracid acid effervescent tablet in 250ml water can fater disintegration, the time exists
In in 5min, most fastly in 2min, that is, disintegratable.
2. bactericidal effect is tested
Test content: killing effect test is carried out to Escherichia coli using prepared trichloroiminocyanuracid acid effervescent tablet
Test method: Suspension quantitative bactericidal test utilizes sym-closene disinfection effervescence tablet pair prepared by embodiment 1
Escherichia coli carry out sterilization test；1 disinfection tablet is placed in concentration 1 × 108cfu/mL~5 × 108cfu/mL Escherichia coli
It is sterilized in solution, test is repeated 3 times.
The specific test method is as follows:
(1) thimerosal is prepared using Sterile Hard Water, it is spare sets 20 DEG C of ± 1 DEG C of water-baths；
(2) it needs to prepare test bacteria suspension, suspension concentration should reach 1 × 108Cfu/mL~5 × 108cfu/mL；
(3) sterile test tube is taken, the above-mentioned bacteria suspension of 0.5mL is first added, adds 0.5mL 3%BSA, mixes, sets 20 DEG C ± 1
In DEG C water-bath after 5min, draws configured thimerosal 4.0mL and be added in test tube, should mix rapidly and start to clock；
(4) effect is drawn above-mentioned mixed liquor 0.5mL and is added in sterilized neutralizer, neutralizer to preheating setting time
Volume is 4.5mL, mixes, takes final sample liquid 0.1mL, be inoculated in plate；
(5) each plate is measured the bacterium of survival by the method that viable bacteria culture counts, and every kind of sample liquid is inoculated with 2 and puts down
Ware；In experimental result if when the clump count grown on plate is more, 10 times of serial dilutions can be carried out to above-mentioned sample liquid, then
Viable bacteria culture is carried out to plate again to count；
(6) thimerosal is replaced with LB culture medium simultaneously, parallel laboratory test is carried out, as positive control；
(7) all plates are both placed in 37 DEG C of incubators and cultivate, and to bacterial propagule disinfecting effect observing, should cultivate
After 48h；It should be after cultivating 72h to bacterial spore disinfecting effect observing；
(8) sterilization test needs are repeated 3 times, and the plate of each group carries out viable bacteria concentration (cfu/mL), and are scaled corresponding
Logarithm (N), then formula is calculated logarithm is killed as follows:
KL=No-Nx
Wherein, KL --- kill logarithm；No --- the logarithm of control group mean viable concentration；Nx --- test group is living
Bacteria concentration logarithm.
Killing test is carried out to Escherichia coli using effervescent tablet prepared by example 1, test result is as follows shown in table.
Killing of the trichloroiminocyanuracid acid effervescent tablet to test organisms
In upper table as the result is shown: under room ambient conditions, being utilized respectively available chlorine content is 1600mg/L, 800mg/L disinfectant
Effect 10min, 5min averagely kill logarithm to Escherichia coli and are all larger than 5.00 for 8.75,8.75,8.01,8.75, meet and " disappear
Malicious technical specification " regulation.
3. antivirus test
Test method: antivirus test, tool are carried out to virus using trichloroiminocyanuracid acid effervescent tablet prepared by embodiment 1
Body method is as follows:
(1) SPF grade C57BL/6 mouse 16 for choosing 7-9 week old, are divided into 4 groups, every group 4；
(2) in cell platform, 3% penta bars of ratios 1. the corresponding reagent of configuration mouse collunarium test: are configured using physiological saline
Appropriate sodium；2. taking 100uL sample liquid that 100uL is added after 100uL virus (H1N1) is added in 400uL disinfectant 800mg/L effect 5min
Neutralizer mixes, and final sample liquid is as experiment reagent；3. 400uL disinfectant 1600mg/L effect is added in 100uL virus (H1N1)
It after in 5min, takes 100uL sample liquid that 100uL neutralizer is added, mixes, final sample liquid is experiment reagent；4. 100uL disinfectant is added
The neutralizer of 100uL；5. virus stock solution used；
(3) syringe for utilizing 1mL, according to the injection volume of 40mg/kg, to intraperitoneal injection 3% yellow Jackets (by
In there are individual differences, different to the tolerance of yellow Jackets, therefore, individual mice is likely to occur the feelings that do not faint
Condition can slightly increase the dosage of some yellow Jackets)；
(4) after mouse syncope, using the liquid-transfering gun of 10uL, by it is above-mentioned 2., 3., 4., 5. sample liquid, be respectively dropped into 4 groups small
In mouse nasal cavity, the sample liquid that 20uL is added dropwise in every mouse (needs slowly to carry out, guarantees that sample liquid is inhaled into nasal cavity during collunarium
It is interior)；
5) continuous 14 days, mouse is observed daily, counts the death toll of every group of mouse.
Test result is as follows shown in table:
The result shows that: in 4 groups of mouse, the group only tested using viral H1N1 mouse adapted strain is real at 14 days
After testing, there is a dead mouse, survival rate 75%.Do not occur death by the mouse that disinfectant is handled.
The foregoing is only a preferred embodiment of the present invention, but the scope of protection of the invention be not limited thereto,
Any modification that anyone skilled in the art is made in the technical scope disclosed by the present invention, equivalent replacement and
Improve etc., it should be included within the protection scope of invention.
Claims (5)
1. a kind of sym-closene disinfection effervescence tablet, which is characterized in that consist of the following mass percentage components:
Sym-closene 20~40%, disintegrating agent 40~55%, citric acid 5~10%, sodium sulphate 4~14%, sodium chloride 0.5
~1%, essence is less than 1%.
2. sym-closene disinfection effervescence tablet according to claim 1, it is characterised in that by following mass percent
Group is grouped as:
Sym-closene 25~40%, disintegrating agent 45~55%, citric acid 5~10%, sodium sulphate 9~14%, sodium chloride 0.5
~1%, essence is less than 1%.
3. sym-closene disinfection effervescence tablet according to claim 1, it is characterised in that: the disintegrating agent is by bicarbonate
Sodium and water soluble starch composition.
4. sym-closene disinfection effervescence tablet according to claim 2, it is characterised in that: the sodium bicarbonate with it is water-soluble
Property starch mass ratio be 8:1.
5. a kind of preparation method of sym-closene disinfection effervescence tablet described in claim 1, which is characterized in that including following
Step:
(1) it is sieved: the processing of 80-100 mesh was carried out to each raw material；
(2) it mixes: being stirred evenly after each raw material is mixed；
(3) tabletting: the raw material after mixing is put into tablet press machine and is pelletized to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910377865.2A CN110012904A (en) | 2019-05-07 | 2019-05-07 | A kind of sym-closene disinfection effervescence tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910377865.2A CN110012904A (en) | 2019-05-07 | 2019-05-07 | A kind of sym-closene disinfection effervescence tablet and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110012904A true CN110012904A (en) | 2019-07-16 |
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| CN201910377865.2A Pending CN110012904A (en) | 2019-05-07 | 2019-05-07 | A kind of sym-closene disinfection effervescence tablet and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI727680B (en) * | 2020-02-27 | 2021-05-11 | 超水國際股份有限公司 | Hypochlorous acid disinfectant and its production method |
| CN114557357A (en) * | 2022-03-01 | 2022-05-31 | 青岛鲁恩环境科技有限公司 | Soil bactericide |
| CN115152756A (en) * | 2022-06-07 | 2022-10-11 | 沈阳化工大学 | Clathrate compound disinfection tablet and preparation method thereof |
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|---|---|---|---|---|
| JPS5620512A (en) * | 1979-07-27 | 1981-02-26 | Nissan Chem Ind Ltd | Rapidly disintegrable isocyanuric acid tablet |
| CN1600102A (en) * | 2003-09-28 | 2005-03-30 | 江苏北方氯碱集团有限公司 | Bactericin agent of trichloro-isocyanuric acid |
| WO2012139247A1 (en) * | 2011-04-12 | 2012-10-18 | Xu Ni | A method of making chlorine dioxide |
-
2019
- 2019-05-07 CN CN201910377865.2A patent/CN110012904A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5620512A (en) * | 1979-07-27 | 1981-02-26 | Nissan Chem Ind Ltd | Rapidly disintegrable isocyanuric acid tablet |
| CN1600102A (en) * | 2003-09-28 | 2005-03-30 | 江苏北方氯碱集团有限公司 | Bactericin agent of trichloro-isocyanuric acid |
| WO2012139247A1 (en) * | 2011-04-12 | 2012-10-18 | Xu Ni | A method of making chlorine dioxide |
Non-Patent Citations (1)
| Title |
|---|
| 杨继彰编著: "《药剂学》", 31 May 1957, 上海卫生出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI727680B (en) * | 2020-02-27 | 2021-05-11 | 超水國際股份有限公司 | Hypochlorous acid disinfectant and its production method |
| EP3881678A3 (en) * | 2020-02-27 | 2022-01-19 | Wen Chung Shiao | Hypochlorous acid disinfectant and its production method |
| US11638429B2 (en) | 2020-02-27 | 2023-05-02 | Super Aqua International Co., Ltd. | Hypochlorous acid disinfectant and its production method |
| CN114557357A (en) * | 2022-03-01 | 2022-05-31 | 青岛鲁恩环境科技有限公司 | Soil bactericide |
| CN115152756A (en) * | 2022-06-07 | 2022-10-11 | 沈阳化工大学 | Clathrate compound disinfection tablet and preparation method thereof |
| CN115152756B (en) * | 2022-06-07 | 2024-01-16 | 沈阳化工大学 | Clathrate disinfection tablet and preparation method thereof |
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