CN109966176A - A kind of skin wrinkle composition and its application - Google Patents

A kind of skin wrinkle composition and its application Download PDF

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Publication number
CN109966176A
CN109966176A CN201711464541.XA CN201711464541A CN109966176A CN 109966176 A CN109966176 A CN 109966176A CN 201711464541 A CN201711464541 A CN 201711464541A CN 109966176 A CN109966176 A CN 109966176A
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vinyl
reagent
organopolysiloxane
skin
composition
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伊丽英
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/895—Polysiloxanes containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

The present invention relates to a kind of skin wrinkle composition and its applications.Specifically, the present invention provides a kind of for medical and/or beauty dermal application composition, and the composition includes: (1) first reagent: VQM vinyl polysiloxane；(2) second reagents: hydrogeneous organopolysiloxane；(3) metallic catalyst.Skin wrinkle beauty product prepared by the present invention has the characteristics such as good elasticity, environmental resistance and skin adherence, and required aesthetic method and appearance can be provided for consumer.The purposes of skin-covering agent or spread product of the invention in terms of medical treatment includes administration, regards drug excipient, sustained-release administration, hemostasis, isolation, protection local skin from pressure injury; prevent bite by mosquitos; aid in skin externally applied drug administration process, scar reparation, treating skin disease etc..

Description

A kind of skin wrinkle composition and its application
Technical field
The invention belongs to skin products fields, and in particular to one kind is for beauty and/or skin medical composition and its answers With.
Background technique
Currently, the appearance for mitigating skin defect, such as the means of wrinkle, microgroove include invasion and Non-Invasive skill Art.Aggressive techniques are for example performed the operation, filler, laser surface are rebuild or can provide more longlasting effect and can treat protrusion Defect.And the example of non-invasive method include by by foundation cream type makeup application to skin or coating include can be at any time Mitigate the cosmetic formulation (for example, anti-wrinkle creme) of the ingredient of the appearance of defect and conceals defects.Regrettably, foundation make-up It is not durable, and the appearance of significant skin defect, such as deep wrinkle cannot be mitigated, and containing the appearance that can mitigate defect at The cosmetic formulation needs divided take a long time and could work, and more apparent skin defect is not acted on.Especially Ground, many existing cosmetic formulations are without mechanical performance needed for capable of beautifying notable defect.
Heavy polymer (including protein and polysaccharide) has been attempted for developing anti-aging skin care cosmetic system Agent.Although these polymer can change the physical property (for example, elasticity and rigidity) of skin when being applied to skin, no It can improve as repeating skin problem such as wrinkle caused by facial movement naturally.
Skin is the natural barrier of human body, protects body itself, and extraneous harmful substance is isolated.If skin occur wound or Skin disease occurs for person, and most common treatment means are exactly that local window is handled or through percutaneous drug delivery.Due to wearing the clothes or moving, External preparation for skin medicine utilization rate after smearing is not high, and influences patient and move freely.Furthermore presently commercially available some wounds, which are handled, uses Product, such as medical adhesive tape or adhesive bandage, other than allergy, body-sensing can be caused uncomfortable, appearance also lacks aesthetic feeling.Potential city herein Under the demand of field, the present invention can protect skin, improves the quality of life after percutaneous drug delivery, facilitates treating for skin disease and skin Reparation.
Currently available technology uses linear molecule, and crosslink density is low, intensity difference.It needs to reach by adding a large amount of enhancing ingredients To the mechanical strength of needs.Thus the problem of bringing is product viscosity height, needs to add surfactant and water etc. and is prepared into cream Liquid pattern.The Product Process of the method preparation is complicated, and the duration is short, and product flexibility difference causes easy to fall off.
To sum up, this field needs to develop a kind of skin with characteristics such as good elasticity, environmental resistance and skin adherences Skin articles can provide required aesthetic method and skin perception for consumer, or meet medical demand.
Summary of the invention
The purpose of the present invention is to provide a kind of skin wrinkle composition and its application, the composition can be used for assisting The reparation of the administration process or skin for the treatment of skin disease.
The first aspect of the present invention provides a kind of for medical and/or beauty dermal application composition, the combination Object includes the first reagent and the second reagent, wherein
First reagent includes: VQM vinyl polysiloxane；
Second reagent includes: hydrogeneous organopolysiloxane；
And in the composition further include: metallic catalyst.
In another preferred example, the metallic catalyst is placed in the first reagent and/or the second reagent.
In another preferred example, first reagent and the second reagent are that integrated and described metallic catalyst is made It is provided for third reagent.
In another preferred example, the VQM vinyl polysiloxane is to contain Q chain link [structure SiO2], M group [knot Structure is (CH3)3SiO0.5] and vinyl-functional.
In another preferred example, first reagent also contains vinyl organopolysiloxane.
In another preferred example, the vinyl organopolysiloxane is selected from the group: single functionality vinyl is organic poly- Siloxanes, polyfunctionality vinyl organopolysiloxane, or combinations thereof.
In another preferred example, the polyfunctionality vinyl organopolysiloxane is containing two or more degrees of functionality Vinyl organopolysiloxane.
In another preferred example, the contents of ethylene 0.028-3mmol/ of the single functionality vinyl organopolysiloxane g。
In another preferred example, the contents of ethylene of the polyfunctionality vinyl organopolysiloxane is in 0.015- 4mmol/g。
In another preferred example, the vinyl of the vinyl organopolysiloxane can be located in segment end group or segment Portion.
In another preferred example, the range of viscosities of the single functionality vinyl organopolysiloxane is in 6-20, 000mPas。
In another preferred example, the range of viscosities of the polyfunctionality vinyl organopolysiloxane is in 6-165, 000mPas。
In another preferred example, the range of viscosities of the polyfunctionality vinyl organopolysiloxane is in 2-165, 000mPas。
In another preferred example, the hydrogeneous organopolysiloxane is the hydrogeneous organopolysiloxane of polyfunctionality.
In another preferred example, the hydrogeneous organopolysiloxane of the polyfunctionality is containing two or more Si -- Hs Organopolysiloxane.
In another preferred example, the hydrogeneous organopolysiloxane of the polyfunctionality each molecule that is averaged at least contains 3 The organopolysiloxane of a or above Si -- H.
In another preferred example, the Si-H content 0.16-16mmol/g of the hydrogeneous organopolysiloxane of the polyfunctionality.
In another preferred example, the Si-H content of the hydrogeneous organopolysiloxane of the polyfunctionality is in 0.16-8mmol/g.
In another preferred example, the main chain end of the hydrogeneous organopolysiloxane of the polyfunctionality is PDMS.
In another preferred example, the range of viscosities of the hydrogeneous organopolysiloxane of the polyfunctionality is in 4-500mPas.
In another preferred example, the metallic catalyst is Pt catalyst.
In another preferred example, the Pt catalyst is selected from: platinum carbonyl ring, vinyl methyl siloxane complex compound, platinum Divinyl tetramethyl disiloxane complex compound, platinum loop vinyl methyl siloxane complex compound, platinum octanal/octanol complex, or A combination thereof.
In another preferred example, first reagent and/or the second reagent can also include being selected from down each independently Group component: non-reactive diluent, supporting material, reaction speed regulator, color regulator, preservative, pigment, fragrance, Skin treating active component, or combinations thereof.
In another preferred example, the non-reactive diluent is not occur with other compositions in first reagent The carrier of reaction.
In another preferred example, the non-reactive diluent includes the copolymerization of silicone oil, polydimethylsiloxane, polyethers Object, or combinations thereof.
In another preferred example, the silicone oil does not contain reactive group.
In another preferred example, the range of viscosities of the silicone oil is in 6-5000mPas.
In another preferred example, the supporting material is inorganic powder materials.
In another preferred example, the inorganic powder materials are selected from the group: mica, zinc oxide, titanium dioxide, oxidation Aluminium, clay, silica, or combinations thereof.
In another preferred example, the silica is selected from the group: fumed silica, modified fumed silica, Or combinations thereof.
In another preferred example, the reaction speed regulator is selected from the group: Vinyl D4, double-seal head, the resistance of alkynol class Poly- agent, or combinations thereof.
In another preferred example, the color regulator is selected from the group: nylon particle, titanium dioxide, iron oxide or its Combination.
In another preferred example, second reagent further include: reactive diluent；And work as the second reagent packet It does not include metallic catalyst in second reagent when including reactive diluent.
In another preferred example, the reactive diluent is vinyl organopolysiloxane.
In another preferred example, in first reagent and the second reagent, the total content of vinyl and always containing for silicon hydrogen The molar ratio of amount is 1:0.8-15；Preferably 1:1.5-15.
In another preferred example, first reagent includes: VQM vinyl polysiloxane, and polyfunctionality vinyl is organic Polysiloxanes, and optional component selected from the group below: Pt catalyst, single functionality vinyl organopolysiloxane, silicone oil, reinforcement Filler, reaction speed regulator, color regulator, preservative, pigment, fragrance, skin treating active component.
In another preferred example, second reagent includes: the hydrogeneous organopolysiloxane of polyfunctionality and optional choosing From the component of the following group: Pt catalyst, VQM resin, single functionality vinyl organopolysiloxane, polyfunctionality vinyl are organic poly- Siloxanes, silicone oil, reinforced filling, reaction speed regulator, color regulator, preservative, pigment, fragrance, skin treating active Component.
In another preferred example, in first reagent, the mass fraction of VQM vinyl polysiloxane is 5-60 weight Part, the mass fraction of vinyl organopolysiloxane is 20-60 parts by weight, and the quality of catalyst is divided into 0.05-1 parts by weight.
In another preferred example, in second reagent, the mass fraction of hydrogeneous organopolysiloxane is 1-50 weight Part is measured, the mass fraction of VQM vinyl polysiloxane is 0-50 parts by weight, and the mass fraction of vinyl organopolysiloxane is 0-60 Parts by weight, the mass fraction of supporting material are 0-18 parts by weight.
In another preferred example, first reagent includes: that VQM resin 15-50 parts by weight, single functionality vinyl have Machine polysiloxanes 25-50 parts by weight, polyfunctionality vinyl organopolysiloxane 0-50 parts by weight, Pt catalyst 0.05-1 weight Part, reinforced filling 0-18 parts by weight.
In another preferred example, second reagent includes: that VQM resin 0-50 parts by weight, single functionality vinyl have Machine polysiloxanes 10-50 parts by weight, the hydrogeneous organopolysiloxane mass fraction of polyfunctionality are in 1-50 parts by weight, reinforced filling 0- 18 parts by weight.
In another preferred example, first reagent includes: that VQM resin 5-40 parts by weight, polyfunctionality vinyl have Machine polysiloxanes 20-60 parts by weight, single functionality vinyl organopolysiloxane 0-50 parts by weight, Pt catalyst 0.05-1 weight Part, reinforced filling 0-18 parts by weight.
In another preferred example, second reagent includes: that VQM resin 0-50 parts by weight, single functionality vinyl have Machine polysiloxanes 0-50 parts by weight, the hydrogeneous organopolysiloxane 1-50 parts by weight of polyfunctionality, polyfunctionality vinyl are organic poly- 0-50 parts by weight of siloxanes, reinforced filling 0-18 parts by weight.
In another preferred example, first reagent is VQM vinylite, optional vinyl organopolysiloxane And catalyst, second reagent are hydrogeneous organopolysiloxane, optional vinyl organopolysiloxane and VQM vinyl Resin.
The second aspect of the present invention, provides a kind of beauty treatment material, the material object include: with containing vinyl molecule with The polymer that hydrogeneous organopolysiloxane reacts；Wherein, described is VQM vinyl polysiloxane containing vinyl molecule.
In another preferred example, the vinyl molecule that contains also contains vinyl organopolysiloxane.
In another preferred example, the vinyl organopolysiloxane is selected from the group: single functionality vinyl is organic poly- Siloxanes, polyfunctionality vinyl organopolysiloxane, or combinations thereof.
In another preferred example, the reaction carries out in the presence of metallic catalyst.
In another preferred example, the content of the medium vinyl containing vinyl molecule and hydrogeneous organic poly- silicon oxygen The molar ratio of the content of silicon hydrogen in alkane is 1:0.8-15；Preferably 1:1.5-15.
The third aspect of the present invention provides a kind of preparation method of beauty treatment material described in second aspect of the present invention, uses It is reacted containing vinyl molecule and hydrogeneous organopolysiloxane, obtains the composition.
The fourth aspect of the present invention, provides a kind of cosmetic products, and the cosmetics include first aspect present invention institute Beauty treatment material described in the composition or second aspect of the present invention stated.
The fifth aspect of the present invention provides a kind of purposes of composition described in first aspect present invention, is used to prepare Cosmetics, or it is used to prepare skin treatment agent.
In another preferred example, the cosmetics be the cosmetics with purposes selected from the group below: smoothing wrinkle, go eye pouch, Microgroove, concealing, isolation, sun-proof is removed, or combinations thereof.
In another preferred example, when the composition is used to prepare skin treatment agent, as component selected from the group below: medicine Object excipient, scar repair agent, skin treatment agent, hemostat, interleaving agent.
In another preferred example, the skin treatment agent is sustained release preparation.
In another preferred example, the skin treatment agent is for protecting local skin from pressure injury.
In another preferred example, the skin treatment agent is for preventing bite by mosquitos.
In another preferred example, the skin treatment agent is used for scar reparation.
In another preferred example, the skin treatment agent is used for treating skin disease.
It should be understood that above-mentioned each technical characteristic of the invention and having in below (eg embodiment) within the scope of the present invention It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist This no longer tires out one by one states.
Specific embodiment
The present inventor after extensive and in-depth study, has obtained a kind of by containing second containing VQM vinyl polysiloxane Olefinic base material is combined with what the hydrosilylation addition reaction that silane containing hydrogen occurs generated for medical and/or beauty dermal application Object.By the first reagent and the second reagent of composition hydrosilylation addition reaction occurs under conditions of catalyst for the present invention, hands over Connection forms skin except cosmetic products, can play mitigation wrinkle, eye pouch, the flaw etc. that cosmetics are isolated or cover on skin is made With, and can be with assistance application in external preparation for skin medicine administration process, scar reparation and treating skin disease etc..Based on above-mentioned discovery, Inventor completes the present invention.
Term
As used herein, " VQM vinyl polysiloxane " and " vinyl MQ resin " are used interchangeably, a kind of preferred VQM Resin is cross-linked network, and end group, which contains vinyl, may participate in silicon hydrogenation.Its illustrative structure is shown below.It is excellent In the case of choosing, contents of ethylene 0.2-1.5mmol/g.
As used herein, term " hydrogeneous organopolysiloxane " and " containing hydrogen silicone oil " are used interchangeably, and refer both to end group, side chain Or contain the dimethyl silicone polymer of Si -- H on branch.
As described herein, term " polyfunctionality vinyl organopolysiloxane " refers to the second containing two or more degrees of functionality Alkenyl organopolysiloxane.
As described herein, term " the hydrogeneous organopolysiloxane of polyfunctionality " refers to containing two or more degrees of functionality are hydrogeneous and has Machine polysiloxanes.
As described herein, term " more than " should be understood as including this number.
As described herein, term " PDMS " refers to dimethyl silicone polymer.
As described herein, term " Vinyl D4 " refers to t etram-ethyltetravinylcyclotetrasiloxane.
As described herein, term " double-seal head " refers to tetramethyl divinyl disiloxane.
As described herein, term " nylon particle " refers to Nylon 10-I2.
As described herein, term " containing " and " comprising " are used interchangeably, and are included not only closed definition, are further included half envelope It closes, open definition.In other words, the term include " by ... constitute ", " substantially by ... constitute ".
Medical and/or beauty dermal application composition
Due to medical and/or beauty dermal application composition be by vinyl and silane containing hydrogen under catalysts conditions Hydrosilylation addition reaction crosslinking occurs to generate, in the presence of catalyst, needs to separate containing vinyl and silane containing hydrogen component, Exempt to crosslink reaction, when in use, vinyl, silane containing hydrogen group and catalyst are mixed, crosslinking reaction and generating has skin The composition of skin smoothing wrinkle.In this regard, the present invention provides a kind of in the presence of catalyst, vinyl and silane containing hydrogen component are separated Skin wrinkle composition.
In the present invention, medical and/or beauty dermal application composition includes the first reagent and the second reagent, wherein described First reagent includes VQM vinyl polysiloxane；Second reagent includes: hydrogeneous organopolysiloxane, and the composition In further include metallic catalyst.
In a preferred embodiment of the present invention, the metallic catalyst is placed in the first reagent and/or the second examination In agent.
In another preferred embodiment, the metallic catalyst can also be separately as third reagent in the composition Middle offer, this embodiment are interpreted as the equivalent form of the application composition.
In another preferred embodiment, in the composition, first reagent and second reagent can also Be it is integrated, in this case, the metallic catalyst is provided separately as third reagent.
In another preferred embodiment, the VQM vinyl polysiloxane is to contain Q chain link [structure SiO2], M base [structure is (CH for group3)3SiO0.5] and vinyl-functional.
In the present invention in a preferred embodiment, in the skin wrinkle composition, first reagent also contains There is vinyl organopolysiloxane.The vinyl organopolysiloxane is not particularly limited, second commonly used in the art Alkenyl organopolysiloxane all can be used.Preferred vinyl organopolysiloxane is selected from the group: single functionality vinyl is organic Polysiloxanes, polyfunctionality vinyl organopolysiloxane, or combinations thereof.In another preferred example, the polyfunctionality second Alkenyl organopolysiloxane is the vinyl organopolysiloxane of two or more degrees of functionality.
In another preferred embodiment, the contents of ethylene 0.028- of the single functionality vinyl organopolysiloxane 3mmol/g。
In another preferred embodiment, the contents of ethylene of the polyfunctionality vinyl organopolysiloxane exists 0.015-4mmol/g。
In another preferred embodiment, the vinyl of the vinyl organopolysiloxane can be located at any position of segment It sets, such as in the middle part of segment end group or segment.
In another preferred example, the range of viscosities of the single functionality vinyl organopolysiloxane is in 6-20, 000mPas.In another preferred example, the range of viscosities of the polyfunctionality vinyl organopolysiloxane is in 6-165, 000mPas.In another preferred example, the range of viscosities of the polyfunctionality vinyl organopolysiloxane is in 2-165, 000mPas。
The second reagent in skin wrinkle composition includes hydrogeneous organopolysiloxane.In the preferred embodiment of the present invention In, the hydrogeneous organopolysiloxane is the hydrogeneous organopolysiloxane of polyfunctionality.
In another preferred example, the hydrogeneous organopolysiloxane of the polyfunctionality is containing two or more Si -- Hs Organopolysiloxane.
In another preferred example, the hydrogeneous organopolysiloxane of the polyfunctionality each molecule that is averaged at least contains 3 The organopolysiloxane of a or above Si -- H.In another preferred example, the hydrogeneous organic poly- silicon oxygen of the polyfunctionality Si-H the content 0.16-16mmol/g, preferably 0.16-8mmol/g of alkane.
In another preferred example, the main chain end of the hydrogeneous organopolysiloxane of the polyfunctionality is PDMS.
The range of viscosities of the preferred hydrogeneous organopolysiloxane of polyfunctionality is in 4-500mPas.The viscosity Properties of product are had not significant impact, but different texture can be brought to product, can be selected according to used product type With suitable type.
In order to react silicon hydrogenation under mild conditions, needs to be added catalyst and be catalyzed, the choosing of catalyst The rate for influencing reaction is selected, therefore, selects suitable catalyst that can promote the progress of reaction.In the preferred embodiment of the present invention In, the metallic catalyst in composition is Pt catalyst；Preferably, the Pt catalyst is selected from: platinum carbonyl ring, vinyl first Radical siloxane complex compound, platinum divinyl tetramethyl disiloxane complex compound, platinum loop vinyl methyl siloxane complex compound, platinum are pungent Aldehyde/octanol complex, or combinations thereof.
Enable to skin wrinkle composition with preferable viscosity, by force by the way that other additives are added in the composition The characteristics such as degree, elasticity, color, stability can also add the rate of reaction speed regulator control reaction as needed.Another In one preferred embodiment, first reagent and/or the second reagent can also include component selected from the group below each independently: Non-reactive diluent, supporting material, reaction speed regulator, color regulator, preservative, pigment, fragrance, skin treating are living Property component, or combinations thereof.In another preferred example, the non-reactive diluent be not with other in first reagent The carrier that ingredient reacts；In another preferred example, the non-reactive diluent is silicone oil, polydimethylsiloxane, gathers The copolymer of ether, or combinations thereof.In another preferred embodiment, the silicone oil does not contain reactive group.In another preference In, the range of viscosities of the silicone oil is in 6-5000mPas.
In another preferred example, the supporting material is inorganic powder materials.In another preferred example, described inorganic Dusty material is selected from the group: mica, zinc oxide, titanium dioxide, aluminium oxide, clay, silica, or combinations thereof.Another excellent It selects in example, the silica is selected from the group: fumed silica, modified fumed silica, or combinations thereof.Another excellent It selects in embodiment, the reaction speed regulator is selected from the group: Vinyl D4, double-seal head, alkynol class polymerization inhibitor or its group It closes.In another preferred embodiment, the color regulator is selected from the group: nylon particle, titanium dioxide, iron oxide or its Combination.
The reagent medium vinyl and silicon hydrogen cross-linking reaction of skin wrinkle composition are preferably in the presence of reactive diluent It carries out.By adjusting the amount of reactive group vinyl and silicon hydrogen and catalyst in reaction reagent, the speed of reaction can be controlled And degree, thus preparation be suitble to have skin wrinkle composition.
In the preferred embodiment of the present invention, the reactive diluent can add in the second reagent； It does not include metallic catalyst in second reagent and when second reagent includes reactive diluent.But ability Field technique personnel should be understood that the reactive diluent can also make an addition to the first reagent, or mention as individual reagent For such equivalent form is also encompassed within the scope of the present invention.
The reactive diluent is not particularly limited, in a preferred embodiment of the invention, reactive diluent For vinyl organopolysiloxane.
The dosage of first reagent and the second reagent can specifically determine according to the component of the two, such as excellent at one It selects in embodiment, the molar ratio of the total content of the total content and silicon hydrogen of vinyl is 1:0.8-15；Preferably 1:1.5-15, and The dosage of first reagent and the second reagent can arbitrarily adjust in the range of meeting above-mentioned molar ratio.
Although the scheme of the application can carry out appropriate adjustment according to specific product, example below can be used as this Shen The example of preferred embodiment please.
In a preference of the invention, first reagent includes: VQM vinyl polysiloxane, polyfunctionality second Alkenyl organopolysiloxane, and optional component selected from the group below: Pt catalyst, single functionality vinyl organopolysiloxane, Silicone oil, reinforced filling, reaction speed regulator, color regulator, preservative, pigment, fragrance, skin treating active component.
In another preferred example, second reagent includes: the hydrogeneous organopolysiloxane of polyfunctionality and optional choosing From the component of the following group: Pt catalyst, VQM resin, single functionality vinyl organopolysiloxane, polyfunctionality vinyl are organic poly- Siloxanes, silicone oil, reinforced filling, reaction speed regulator, color regulator, preservative, pigment, fragrance, skin treating active Component.
In another preferred example, in first reagent, the mass fraction of VQM vinyl polysiloxane is 5-60 weight Part, the mass fraction of vinyl organopolysiloxane is 20-60 parts by weight, and the mass fraction of catalyst is 0.05-1 parts by weight.
In another preferred example, in second reagent, the mass fraction of hydrogeneous organopolysiloxane is 1-50 weight Part is measured, the mass fraction of VQM vinyl polysiloxane is 0-50 parts by weight, and the mass fraction of vinyl organopolysiloxane is 0-60 Parts by weight, the mass fraction of supporting material are 0-18 parts by weight.
In another preferred example, first reagent includes: that VQM resin 15-50 parts by weight, single functionality vinyl have Machine polysiloxanes 25-50 parts by weight, polyfunctionality vinyl organopolysiloxane 0-50 parts by weight Pt catalyst 0.05-1 weight Part, reinforced filling 0-18 parts by weight.
In another preferred example, second reagent includes: that VQM resin 0-50 parts by weight, single functionality vinyl have Machine polysiloxanes 10-50 parts by weight, the hydrogeneous organopolysiloxane mass fraction of polyfunctionality are in 1-50 parts by weight, reinforced filling 0- 18 parts by weight.
In another preferred example, first reagent includes: VQM resin 5-40 parts by weight, the organic poly- silicon of polyfunctionality Oxygen alkane 20-60 parts by weight, Pt catalyst 0.05-1 parts by weight, are mended at single functionality vinyl organopolysiloxane 0-50 parts by weight Strong filler 0-18 parts by weight.
In another preferred example, second reagent includes: that VQM resin 0-50 parts by weight, single functionality vinyl have Machine polysiloxanes 0-50 parts by weight, the hydrogeneous organopolysiloxane 1-50 parts by weight of polyfunctionality, polyfunctionality vinyl are organic poly- Siloxanes 0-50 parts by weight, reinforced filling 0-18 parts by weight.
In another preferred example, first reagent is VQM vinylite, the organic poly- silicon oxygen of optional vinyl Alkane and catalyst, second reagent are hydrogeneous organopolysiloxane, optional vinyl organopolysiloxane and VQM ethylene Base resin.
Beauty treatment material and preparation method thereof
The present invention provides a kind of beauty treatment material, the material includes: with containing vinyl molecule and hydrogeneous organic poly- silicon The polymer that oxygen alkane reacts；Wherein, described to be selected from the group containing vinyl molecule: VQM vinyl polysiloxane.
In another preferred embodiment, the vinyl molecule also contains vinyl organopolysiloxane, preferably, institute The vinyl organopolysiloxane stated is selected from the group: single functionality vinyl organopolysiloxane, polyfunctionality vinyl are organic Polysiloxanes, or combinations thereof.
In another preferred embodiment, the reaction carries out in the presence of metallic catalyst.
In another preferred embodiment, the content of the medium vinyl containing vinyl molecule and described hydrogeneous organic poly- The molar ratio of the content of silicon hydrogen in silicon oxygen Anhui is 1:0.8-15；Preferably 1:1.5-15.
The present invention provides a kind of preparation method of beauty treatment material, with containing vinyl molecule and hydrogeneous organopolysiloxane into Row reaction, obtains the beauty treatment material.
The beauty treatment material can be prefabricated, or prepare on the spot when in use, for example, by using such as present invention first Composition shown in aspect is prepared.
Cosmetic products
The present invention provides a kind of cosmetic products, and the cosmetic products include composition of the present invention, or the present invention The beauty treatment material.
The additive or component of composition of the present invention and the beauty treatment material as cosmetic products, are prepared into Other forms are provided, such as can achieve the effect that discharge for a long time by addition skin supplement ingredient, or by incite somebody to action this Product is applied to the skin surface for having smeared drug or skin-nourishing product, releases to reach protection or extend drug/nutriment Put the purpose of time.The product can be applied to make-up and beauty or medical treatment, when being applied to cosmetics, can play smoothing wrinkle, remove eye pouch, go The effects of microgroove, concealing are isolated, sun-proof.
In addition, enhancing ingredients need not be added i.e. when using composition of the invention, in reagent can reach and is identical or better Using effect (intensity).Without adding water and surfactant in reagent, the preparation process of product is required simply, with other productions Condition is more soft than product after solidification, and comfort is stronger.
Purposes
The present invention provides a kind of purposes of composition, are used to prepare cosmetics, or be used to prepare skin treatment agent.
In another preferred example, the cosmetics be the cosmetics with purposes selected from the group below: smoothing wrinkle, go eye pouch, Microgroove, concealing, isolation, sun-proof is removed, or combinations thereof.
In another preferred example, when the composition is used to prepare skin treatment agent, as component selected from the group below: medicine Object excipient, scar repair agent, skin treatment agent, hemostat, interleaving agent.
In another preferred example, the skin treatment agent is sustained release preparation.
In another preferred example, the skin treatment agent is for protecting local skin from pressure injury.
In another preferred example, the skin treatment agent is for preventing bite by mosquitos.
In another preferred example, the skin treatment agent is used for scar reparation.
In another preferred example, the skin treatment agent is used for treating skin disease.
Main advantages of the present invention
1, prepared by the present invention to there is skin wrinkle composition to have good elasticity, environmental resistance and skin adherence etc. special Property, required aesthetic method and appearance can be provided for consumer.
2, the present invention can provide a kind of mode for mitigating wrinkle of skin or eye pouch to produce appreciable results at once.
2, preparation method of the present invention is simple, it is only necessary to be uniformly mixed required component respectively.
4, color and index of refraction and skin of the present invention are close.
5, the present invention can provide a protective layer, directly contact skin to block other cosmetics (such as foundation cream).
6, the present invention without using or only need less enhancing ingredients i.e. and can reach wrinkle effect strong, use the time to grow Effect.
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention Rather than it limits the scope of the invention.In the following examples, the experimental methods for specific conditions are not specified, usually according to conventional strip Or according to the normal condition proposed by manufacturer.
Adopted name
Reagent name Type
VM-37 VQM resin
Polymer MV 2000 Vinyldimethicone
Polymer VS 1000 Vinyldimethicone
Aerosil R202 Fumed silica
SIP6832.2 Pt catalyst mixture
Andisil SF500 Organic silicone oil
Nylon 10-I2 Nylon particle
Crosslinker 100 Hydrogeneous organopolysiloxane
Crosslinker 120 Hydrogeneous organopolysiloxane
Andisil VQM 1 VQM resin compound
Andisil VQM 60 VQM resin compound
DMS V22 Vinyldimethicone
SIP6802.2 Pt catalyst mixture
Aerosil R 8200 Fumed silica
Andisil XL-10 Hydrogeneous organopolysiloxane
Andisil XL-11 Hydrogeneous organopolysiloxane
Andisil CE-500 Hydrogeneous organopolysiloxane
VQM881 VQM resin compound
VQM1773 VQM resin compound
Andisil VS 1000 Vinyldimethicone
SIP6830.3 Pt catalyst mixture
SIP6832.2 Pt catalyst mixture
Andisil CE-13 Hydrogeneous organopolysiloxane
SR1000 QM resin (contains a small amount of hydroxyl)
1 S01M of embodiment and its preparation
The formula of the product is as follows:
S01M Part A
1,2 and 5 is taken to be mixed and heated to 80 DEG C of stirrings until being uniformly mixed.It cools down and is added 3,4,6 and is uniformly mixed.
S01M6 PartB
Reagent Manufacturer Content (%)
1 VM-37 Build orange organosilicon 40.506
2 Polymer MV 2000 Evonik 10.127
3 Polymer VS1000 Evonik 6.329
4 Crosslinker 100 Evonik 29.494
5 Crosslinker 120 Evonik 9.747
6 Nylon 10-I2 Kobo Products 3.797
1,2,4 and 5 is taken to be mixed and heated to 80 DEG C of stirrings until being uniformly mixed.It cools down and is added 3 and 6 and is uniformly mixed.
In use, S01M6PartA and S01M6PartB (1:1 mass ratio) is taken to be placed in the centre of the palm respectively, mixed in 50 seconds equal It is even.The skin surface smeared and needed later.
2 S7M6 of embodiment and its preparation
The formula of the product is as follows:
S7M6 PartA
Reagent Manufacturer Content (%)
1 Andisil VQM 1 An Biyate 41.480
2 Andisil VQM 60 An Biyate 11.211
3 DMS V22 Gelest 20.179
4 SIP6802.2 Gelest 0.224
5 Aerosil R 8200 Evonik 11.211
6 Andisil SF500 Gelest 8.969
7 Nylon 10-I2 Kobo Products 6.726
Preparation: take 1-7 stirring until being uniformly mixed.
S7M6 PartB
Reagent Manufacturer Content (%)
1 Andisil VQM1 An Biyate 30.337
2 Andisil VQM60 An Biyate 11.236
3 DMS V22 Gelest 7.865
4 Andisil XL-10 An Biyate 4.494
5 Andisil XL-11 An Biyate 7.865
6 Aerosil R 8200 Evonik 11.236
7 Andisil CE-500 Evonik 20.225
8 Nylon 10-I2 Kobo Products 6.742
Preparation: take 1-8 stirring until being uniformly mixed.
In use, taking out S01M6PartA and S01M6PartB (1:1 mass ratio) respectively is placed in the centre of the palm, mixed in 50 seconds Uniformly.The skin surface smeared and needed later.
3 S23M2 of embodiment and its preparation
S23M2 PartA
Reagent Manufacturer Content (%)
1 VQM881 Evonik 19.947
2 VQM1773 Evonik 33.245
3 Andisil VS 1000 An Biyate 41.556
4 SIP6830.3 Gelest 0.066
5 SIP6832.2 Gelest 0.199
6 Nylon 10-I2 Kobo Products 4.987
Preparation: take 1-6 stirring until being uniformly mixed.
S23M2 PartB
Preparation: take 1-5 stirring until being uniformly mixed.
In use, taking out S23M2PartA and S23M2PartB (1:1 mass ratio) respectively is placed in the centre of the palm, at 1 point in 30 seconds It is uniformly mixed.The skin surface smeared and needed later.
1 S36M1 of reference examples and its preparation
S36M1 PartA
Reagent Manufacturer Content (%)
1 SR1000 Momentive 19.851
2 Andisil VS 1000 Evonik 60.746
3 SIP6830.3 Gelest 0.597
4 SIP6832.2 Gelest 0.896
5 Aerosil R 8200 Evonik 11.940
6 Nylon 10-I2 Kobo Products 5.970
Preparation: take 1-6 stirring until being uniformly mixed.
S36M1 PartB
Reagent Manufacturer Content (%)
1 SR1000 Momentive 17.624
2 Andisil VS 1000 An Biyate 37.624
3 XL10 An Biyate 5.525
4 XL11 An Biyate 4.696
5 CE500 An Biyate 17.956
6 Aerosil R 8200 Evonik 11.050
7 Nylon 10-I2 Kobo Products 5.525
Preparation: take 1-6 stirring until being uniformly mixed.
Test case
Test method
Subject is screened, before applying product, guarantees that tester does not make up, allows subject first to be washed one's face with facial cleanser, later Immediately ahead of subject and 45 degree of angular direction are taken pictures.Process of taking pictures guarantees that illumination light is unified.
Each reagent taken out in sample respectively is uniformly mixed, and takes sample application uniformly mixed on a small quantity to test zone at once (being respectively as follows: canthus, eye pouch, at cheek and at nose), face's redundant sample is wiped at once.Crow's feet and eye pouch removal effect In test, staff gently tenses the skin of test position after spread product and is kept for 2-10 minutes, 30 after smearing uniformly Water and other liquid must not be touched or contacted in minute, and tester is allowed to leave and tester is required to return in 8-9 hours, It must not rub with the hands to scratch during this and smear position, must not make up, must not wash one's face.It is clapped in fashion described above for subject after subject returns According to.It, can Automatic-falling after membrane swelling with the cotton gently rubbing test position of makeup removing oil infiltration.
Test foundation cream covering effect when, by product mix it is uniform after be applied to the cheek side coarse place of pore, cheek is symmetrical This product is not smeared and directly smears foundation cream in position.Water and other liquid must not be touched or contacted in 30 minutes, later by foundation cream (the permanent moisturizing foundation emulsion of Christian Dior congealed fat) is uniformly applied at product covering.Observe covering effect.
According to test result photo, evaluator is test effect marking, hence it is evident that improving is 8-10 points, it is seen that is improved as 6-8 Point, 6 points the following are do not observe visible improvement.Wherein whether Tou Qi evaluation is completed by subject, and test result is divided into Two options of "Yes" "No".Every subject at most participates in a test daily.
Evaluator's comparison using the photo before product and after use, and provide " significantly reducing " " reducing but unobvious " or The evaluation of " do not reduce or be deteriorated ".Wherein whether Tou Qi evaluation is completed by subject oneself.Every subject at most joins daily Add a test.
The effect (testing 21 people, 50-65 years old age altogether) of the mitigation crow's feet of table 1
The effect (testing 13 people, 50-65 years old age altogether) of the mitigation eye pouch of table 2
The covering effect of pore when table 3 is used together with foundation cream, (testing 15 people altogether, the age is unlimited)
Embodiment 1 and 1 surfaces of tacky of reference examples, foundation cream coating is uneven, therefore does not carry out this test.
Whether table 4 breathes freely, (testing 15 people altogether, the age is unlimited)
Embodiment It is It is no
Embodiment 1 15 0
Embodiment 2 15 0
Embodiment 3 15 0
Reference examples 1 15 0
Test result:
In test process, the case where the failures such as falling off do not occur in all embodiments, it was demonstrated that this product strength and to skin Bonding effect is better than other patented products, and (non-crash rate is respectively 65.38% He to product in the prior art in testing 86.84%).
3 relative intensity of embodiment and hardness highest are also most obvious to skin stretching effect.This effect is mitigating eye pouch process In it is especially prominent.
When being used together with foundation cream, the occlusion effect of 2,3 pairs of pores of embodiment is very good, even for enlarged pores, Also it can reach complete sightless effect.This effect, which is substantially better than, directly uses foundation cream.Embodiment 1 and 1 surfaces of tacky of reference examples, Uniformity is bad after foundation cream is smeared, therefore does not carry out this test.
Experiments have shown that all test results are better than reference examples.It is all test be discovery skin have it is airtight etc. uncomfortable Situation.
All references mentioned in the present invention is incorporated herein by reference, independent just as each document It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can To make various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims It encloses.

Claims (10)

1. a kind of for medical and/or beauty dermal application composition, which is characterized in that the composition includes the first reagent With the second reagent, wherein
First reagent includes: VQM vinyl polysiloxane；
Second reagent includes: hydrogeneous organopolysiloxane；
And in the composition further include: metallic catalyst.
2. examination composition as described in claim 1, which is characterized in that first reagent also contains the organic poly- silicon of vinyl Oxygen alkane, preferably, the vinyl organopolysiloxane is selected from the group: single functionality vinyl organopolysiloxane, more officials Energy degree vinyl organopolysiloxane, or combinations thereof.
3. composition as described in claim 1, which is characterized in that the metallic catalyst is Pt catalyst；Preferably, institute The Pt catalyst stated is selected from: platinum carbonyl ring, vinyl methyl siloxane complex compound, the complexing of platinum divinyl tetramethyl disiloxane Object, platinum loop vinyl methyl siloxane complex compound, platinum octanal/octanol complex, or combinations thereof.
4. composition as described in claim 1, which is characterized in that first reagent and/or the second reagent can also be each From independently include component selected from the group below: non-reactive diluent, supporting material, reaction speed regulator, color regulator, Preservative, pigment, fragrance, skin treating active component, or combinations thereof.
5. composition as described in claim 1, which is characterized in that second reagent further include: reactive diluent；And It does not include metallic catalyst in second reagent when second reagent includes reactive diluent.
6. composition as described in claim 1, which is characterized in that first reagent be VQM vinylite, optionally Vinyl organopolysiloxane and catalyst, second reagent is that hydrogeneous organopolysiloxane, optional vinyl have Machine polysiloxanes and VQM vinylite.
7. a kind of beauty treatment material, which is characterized in that the material includes: with containing vinyl molecule and hydrogeneous organopolysiloxane React obtained polymer；Wherein, described is VQM vinyl polysiloxane containing vinyl molecule.
8. the preparation method of beauty treatment material as described in claim 7, which is characterized in that with containing vinyl molecule and hydrogeneous having Machine polysiloxanes is reacted, and the beauty treatment material is obtained.
9. a kind of cosmetic products, which is characterized in that the cosmetic products include composition as described in claim 1, or such as Beauty treatment material as claimed in claim 7.
10. the purposes of composition as described in claim 1, which is characterized in that be used to prepare cosmetics, or be used to prepare skin Therapeutic agent.
CN201711464541.XA 2017-12-28 2017-12-28 A kind of skin wrinkle composition and its application Withdrawn CN109966176A (en)

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