CN109966029A - Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems - Google Patents
Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems Download PDFInfo
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- CN109966029A CN109966029A CN201711463451.9A CN201711463451A CN109966029A CN 109966029 A CN109966029 A CN 109966029A CN 201711463451 A CN201711463451 A CN 201711463451A CN 109966029 A CN109966029 A CN 109966029A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1604—Chisels; Rongeurs; Punches; Stamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/16—Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
- A61B17/1659—Surgical rasps, files, planes, or scrapers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4603—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2857—Bones for cadavers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4601—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
- A61F2002/3071—Identification means; Administration of patients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30759—Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30761—Support means for artificial cartilage, e.g. cartilage defect covering membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dentistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Prostheses (AREA)
Abstract
The operational tool group and cartilage repair systems that the present invention discloses a kind of repair of cartilage carrier, is arranged in pairs or groups.Repair of cartilage carrier includes ontology and multiple positioning columns.Ontology is for cellular structure and to carry cartilage repair material.Positioning column is fixed to ontology and the os osseum to be inserted into patient.Operational tool group includes locating sleeve and push type instrument.Locating sleeve has connected pathways.There is the first location structure on the side wall of connected pathways.Push type instrument includes outer tube and push rod.There is the second location structure mutually aligned with the first location structure on the outer wall of outer tube.Connected pathways of the outer tube to pass through locating sleeve.Push rod is slidably disposed in outer tube.One end of outer tube has moulding knife, to cut out area to be implanted on the affected part of patient, wherein the shape in area to be implanted corresponds to the shape of ontology.
Description
Technical field
The present invention relates to a kind of carrier, apparatus group and systems, and more particularly to a kind of repair of cartilage carrier, arranged in pairs or groups
Operational tool group and cartilage repair systems.
Background technique
Section cartilaginous tissue is located at the os osseum surface layer of articular surface, is one in tissue with multi-functional and quite special
Tissue, major function be to transmit articular surface up and down the different directions stress of os osseum, absorb os osseum layer transmission articular surface
Impact force, the lubricating joint face that low frictional factor is provided and cooperation muscle ligament tissue, can produce sliding when the joint motion
And the motor pattern of the different directions rolled.
The self-regeneration of cartilaginous tissue and power of regeneration are all very insufficient, once being damaged, often can not voluntarily answer
It is former.According to statistics, at present the U.S. every year because cartilage profound level injure, and need to carry out prosthetic replacement operator up to 200,000 with
On, and case still year by year rise in.However, displacement joint prosthesis need to cut off a large amount of cartilage and os osseum group in patient articular face
It knits, after injury and destructiveness are all quite big, and material implants for the joint prosthesis of metal, ten to 15 Nian Zuo can only be maintained
Right function.For young patient, the pain of prosthetic replacement's operation again will be faced, and for old sufferer, then
The often unbearable operation for replacing joint prosthesis again.Furthermore displacement joint prosthesis likely results in disabled and bad repeatedly
Yu Hang in turn results in society and family's heavy burden.
The treatment method that medical circles are damaged cartilage at present mainly uses cartilage transplantation (cartilage
Transplantation), to repair impaired cartilage block.This method includes by the novel medical method invented in nearly twenty year
Cartilage transplantation (ACI, autologous chondrocyte implantation) and osteoarticular allograft (OA,
Osteoarticular allograft), i.e., using the self or allogeneic new tissue of cartilage transplantation regeneration, it is artificial to can avoid displacement
The permanent damage in joint is also not required to periodically operate on the metal or plastics member of replacement aging again.In above-mentioned treatment method, and with
Cartilage transplantation more widely receives, because its graft source is the tissue of patient itself, allosome will not occur or xenogenesis moves
The problem of planting immunological rejection.
The operation method mainstream of autotransplantation is " mosaic makes up method (Mosaic plasty procedure) ", this method
Itd is proposed by Hungarian surgeon in nineteen ninety-five, the operation method by sufferer joint not by the articular surface cartilage of stress, with
Trepan drills through one piece of cylindric bolt block of os osseum contacted containing cartilage and lower layer, and drills out phase in damaged part with identical trepan
It is inserted with the groove of filling up of diameter, then by the undamaged self soft or hard bone bolt block of health.It is being repaired however, making up method with mosaic
When impacting injury, the cartilage surface between the cartilage bolt block being implanted into has an interface just like ceramic tile, and the cartilage cell between this interface by
In being covered by a large amount of matrix, splitting ability is mutually on duty.Therefore, it in fact and is not easy to form regeneration and melts between cartilage bolt block
It closes；On the other hand, cartilage bolt block peripheral clearance will generate fibrocartilage tissue, cause in the future the face that is wound be also easy to produce degeneration
Arthritis.
Repairing cartilage damage at present with organizational project in vitro culture cartilaginous tissue also has same puzzlement, and, external institute
After by the surface of a wound, the gap fusion problem between new and old cartilaginous tissue can not still be broken through the cartilaginous tissue implantation cartilage of culture at present
Problem.Therefore, how to overcome the regeneration between transplanting cartilage (implant) and former cartilaginous tissue (host) to merge, be current
Quite important and urgently to be resolved Orthopedic Clinical research topic.
Summary of the invention
The operational tool group and cartilage repair systems that the present invention provides a kind of repair of cartilage carrier, is arranged in pairs or groups, can improve existing
There is the problems of repair of cartilage operation.
The repair of cartilage carrier of one embodiment of the invention includes an ontology and multiple positioning columns.Ontology is cellular structure
And to carry cartilage repair material.One end of each positioning column is fixed to ontology, and the other end is to be inserted into the hard of a patient
Bone.
The operational tool group of one embodiment of the invention includes a locating sleeve and a push type instrument.Locating sleeve tool
There is a connected pathways.There is one first location structure on the side wall of connected pathways.Push type instrument includes that an outer tube is pushed away with one
Bar.There is one second location structure on the outer wall of outer tube.Connected pathways of the outer tube to pass through locating sleeve.Second positioning
Structure is mutually aligned with the first location structure.Push rod is slidably disposed in outer tube.One end of outer tube has a moulding
Knife, to cut out an area to be implanted on the affected part of a patient.
The cartilage repair systems of one embodiment of the invention include a repair of cartilage carrier, a locating sleeve and a pressing
Formula instrument.Repair of cartilage carrier includes an ontology and multiple positioning columns.Ontology is for cellular structure and to carry repair of cartilage
Material.One end of each positioning column is fixed to ontology, and os osseum of the other end to be inserted into a patient.Locating sleeve has consistent
Break-through road.There is one first location structure on the side wall of connected pathways.Push type instrument includes an outer tube and a push rod.Housing
There is one second location structure on the outer wall of pipe.Connected pathways of the outer tube to pass through locating sleeve.Second location structure with
First location structure mutually aligns.Push rod is slidably disposed in outer tube.One end of outer tube has a moulding knife, to
An area to be implanted is cut out on the affected part of patient.The shape in area to be implanted corresponds to the shape of ontology.
Based on above-mentioned, in repair of cartilage carrier of the invention, the operational tool group and cartilage repair systems arranged in pairs or groups, tool
The gap fusion for thering is the repair of cartilage carrier of cellular structure to facilitate between new and old cartilaginous tissue, and operational tool group makes cartilage
Repair vector can easily be implanted into the affected part of patient.
To make the foregoing features and advantages of the present invention clearer and more comprehensible, special embodiment below, and it is attached appended by cooperation
Figure is described in detail below.
Detailed description of the invention
Fig. 1 is the schematic diagram of the repair of cartilage carrier of one embodiment of the invention；
Fig. 2 is the entity photo figure of the repair of cartilage carrier of one embodiment of the invention；
Fig. 3 is the schematic diagram of the locating sleeve of the operational tool group of one embodiment of the invention；
Fig. 4 A and Fig. 4 B be respectively the push type instrument of the operational tool group of one embodiment of the invention appearance diagram with
Diagrammatic cross-section；
Fig. 5 is the schematic diagram of the debridement drill bit of the operational tool group of one embodiment of the invention；
Fig. 6 is the schematic diagram of the drilling instrument of the operational tool group of one embodiment of the invention；
Fig. 7 A to Fig. 7 G is each stage that repair of cartilage operation is carried out using the cartilage repair systems of one embodiment of the invention
Photo figure；
Fig. 8 is the schematic diagram of the usage mode of the repair of cartilage carrier of one embodiment of the invention；
Fig. 9 A and Fig. 9 B be respectively the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention and
Affected part photo figure of the reference examples performed the operation using traditional operation apparatus after 6 months restore；
Figure 10 A and Figure 10 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part X-ray figure of the reference examples performed the operation using traditional operation apparatus after 6 months restore；
Figure 11 A and Figure 11 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part sample photo figure of the reference examples performed the operation using traditional operation apparatus after 6 months restore；
Figure 12 A and Figure 12 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part sample photo figure of the reference examples performed the operation using traditional operation apparatus after 12 months restore；
Figure 13 A and Figure 13 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And the stained slice figure of affected part of the reference examples performed the operation using traditional operation apparatus after 12 months restore；
Figure 14 is the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention and the traditional hand of use
The quantization figure of the wound width for the reference examples that art apparatus is performed the operation.
Symbol description
100: repair of cartilage carrier
110: ontology
112: orientation angle
114: groove
120,510: positioning column
200: locating sleeve
210: the first location structures
220: casing positioning column
230: handle
T10: connected pathways
W10: side wall
P10: outlet opening
300: push type instrument
310: outer tube
312: the second location structures
314: moulding knife
314A: orientation angle
320: push rod
330: elastic restoring piece
W20: outer wall
400: debridement drill bit
410: stopper section
500: drilling instrument
520: third location structure
A10: area to be implanted
P20: location hole
Specific embodiment
The operational tool group of one embodiment of the invention includes a locating sleeve and a push type instrument.In addition, this hair
The cartilage repair systems of a bright embodiment further include a repair of cartilage carrier other than above-mentioned operational tool group.
Fig. 1 is the schematic diagram of the repair of cartilage carrier of one embodiment of the invention, and Fig. 2 is that the cartilage of one embodiment of the invention is repaired
The entity photo of multiple carrier.Referring to Fig. 1 and Fig. 2, in one embodiment, this repair of cartilage carrier 100 includes an ontology
110 with multiple positioning columns 120.Ontology 110 is cellular structure, to carry cartilage repair material.Positioning column 120 is solid knot
Structure, one end of each positioning column 120 are fixed to ontology 110, the other end in surgical procedure by the os osseum to be inserted into patient, with
Just entire repair of cartilage carrier 100 is fixed on the os osseum of patient.Selectively, the ontology 110 of the present embodiment can have more
One groove 114, and carried with the space of groove 114 by the material to repair cartilage.
In one embodiment, the ontology 110 of repair of cartilage carrier 100 can allow adjacent groups due to using cellular structure
It knits or cell is entered in the inside of ontology 110 or the space of groove 114 with lubricating fluid by aperture, it is common with cartilage repair material
Affected part is repaired, and then promotes the effect restored.
In one embodiment, biodegradable material can be used in the material of ontology 110.Therefore, in the affected part reparation of patient
After the completion, repair of cartilage carrier 100 natural decomposition and can be metabolized in vivo, the normal cartilage for restoring function be left behind, without staying
Under it is any it is non-human itself natural products in vivo.In one embodiment, the material of ontology 110 can be used single kind of biology can
Degradable material, material composi is more simple, can further shorten the degradable required time.In one embodiment,
The material of ontology 110 can be single high molecular material, e.g. polylactic acid (Polylactide, PLA), polyglycolic acid
(Polyglycolic Acid, PGA), polycaprolactone (Polycaprolactone, PCL), polyvinyl alcohol (Polyvinyl
Alcohol, PVA), poly (hydroxyalkanoate) (polyhydroxy-alkanoates, PHA), but not limited to this.In another embodiment
In, the material of ontology 110 can be composite polymer material, the copolymer (co- of e.g. at least two above-mentioned polymer
Polymer), but not limited to this.
In one embodiment, biodegradable material can be used in the material of positioning column 120.In one embodiment, positioning column
Single kind of biodegradable material can be used in 120 material, and material composi is more simple, can further shorten degradable
The required time.In one embodiment, the material of positioning column 120 can be single high molecular material, e.g. polylactic acid
(Polylactide, PLA), polyglycolic acid (Polyglycolic Acid, PGA), polycaprolactone (Polycaprolactone,
PCL), polyvinyl alcohol (Polyvinyl alcohol, PVA), poly (hydroxyalkanoate) (polyhydroxy-alkanoates, PHA),
But not limited to this.In another embodiment, the material of positioning column 120 can be composite polymer material, on e.g. at least two
The copolymer (co-polymer) of polymer is stated, but not limited to this.The material of the material of ontology 110 and positioning column 120 can phase
It is same or different.
In one embodiment, the porosity of the cellular structure of ontology 110 be 50%~90%, e.g. 50%, 55%,
60%, 65%, 70%, 75%, 80%, 85%, 90%.In addition, the pore size of cellular structure is about 50 μm to 1,000 μ
m.In one embodiment, the appearance kenel of ontology 110 can be discoid or cap shape, but not limited to this.In one embodiment, originally
The diameter of body 110 can be about 8mm to 10mm, be applicable to defect different degrees of on cartilage.The wall thickness of ontology 110 can be 1mm
To 1.5mm, have sufficient intensity to resist the compressing force of surrounding tissue, and is unlikely to be compressed to the storage of cartilage repair material
Space.The total height of ontology 110 can be 1.8mm to 2.2mm, roughly the same with the thickness of human knee joint's cartilage layers, in order to
Os osseum layer is arrived in unlikely infringement in operating process, and knee joint surface will not be protruded from after operation, can avoid by joint surface wear.
In one embodiment, the diameter of positioning column 120 can be 1mm to 2mm, and length can be 2mm to 3mm, and can be solid post
Body, to be fixed on the impaired place of cartilage to destroy least way for a pair of of os osseum for ontology 110.
In one embodiment, the periphery of ontology 110 can have an orientation angle 112.Orientation angle 112 can be about 0.5mm and arrive
The protrusion that the small cusp outstanding of 1mm, e.g. external form are rendered as triangle, but not limited to this.This orientation angle 112 can allow it
Location structure in his surgical instrument, can in surgical procedure auxiliary positioning and repair of cartilage carrier 100 is directed to correctly
Position.
Fig. 3 is the schematic diagram of the locating sleeve of the operational tool group of one embodiment of the invention.Referring to figure 3., locating sleeve
200 have a connected pathways T10.There is one first location structure 210 on the side wall W10 of connected pathways T10.Fig. 4 A and Fig. 4 B points
It is not the appearance diagram and diagrammatic cross-section of the push type instrument of the operational tool group of one embodiment of the invention.A referring to figure 4.
With Fig. 4 B, push type instrument 300 includes an outer tube 310 and a push rod 320.Have one second on the outer wall W20 of outer tube 310
Location structure 312.Connected pathways T10 of the outer tube 310 to the locating sleeve 200 across Fig. 3.Second location structure 312 with
The first location structure 210 of Fig. 3 can be aligned mutually, to ensure that locating sleeve 200 and push type instrument 300 can in operating process
Precise positioning.Push rod 320 is set in outer tube 310 in the form of slidably, by press or push can in outer tube 310 into
Row sliding.One end of outer tube 310 has a moulding knife 314, (does not draw to cut out an area to be implanted on the affected part of patient
Show).The shape in area to be implanted can corresponding diagram 1 ontology 110 shape.
Referring to figure 3., Fig. 4 A and Fig. 4 B, when the outer tube 310 of push type instrument 300 passes through running through for locating sleeve 200
When the T10 of channel, due to being provided with the outer tube 310 of the first location structure 210 and push type instrument 300 in locating sleeve 200
The second location structure 312 is provided on outer wall W20, and the second location structure 312 must be mutually right with the first location structure 210
Position can so limit orientation when push type instrument 300 slides.In addition, being set to the slideable push rod in outer tube 310
320 protrude from outside outer tube 310 in one end far from moulding knife 314.When user pushes push rod 320 to protrude from outer tube 310
When outer one end, push rod 320 can be pushed towards the direction of moulding knife 314.
In one embodiment, the shape of moulding knife 314 can cooperate the shape of the ontology 110 of repair of cartilage carrier 100 to carry out
Moulding knife 314, is this means, designed as consistent with the profile of ontology 110 and configuration by design, is made soft with completely accommodating ontology 110
Bone Defect Repari carrier 100 can be completely placed in region constructed by moulding knife 314.In this way, which user only needs to push away
Bar 320 can push repair of cartilage carrier 100 at affected part target.In other words, push type instrument 300 is in addition to can be with moulding knife
314 cut out except area to be implanted, are also used as pushing away repair of cartilage carrier 100 into the tool toward area to be implanted.In another implementation
It in example, uses for convenience, elastic restoring piece 330, e.g. spring can be set between outer tube 310 and push rod 320, so that
Push rod 320 can automatically reset.
Referring to figure 3., in one embodiment, one end of locating sleeve 200 has multiple casing positioning columns 220, to insert
Enter the affected part of patient, so the position of preliminary stationary positioned casing 200 and tentatively can confine operative site in the course of surgery, with
Just subsequent implementation is accurately performed the operation.The length of casing positioning column 220 can be 8~12mm, for example, 10mm, and casing positioning column
The angle of 220 outer surface and center axis thereof can be 0.5~2 degree, e.g. 1 degree, so that casing positioning column 220 is squeezing into bone
Head can reduce resistance and relatively easily squeeze into bone when being fixed.The diameter of connected pathways T10 can be 12~14mm, example
For example 13mm, it is possible to provide the space of subsequent procedures instrumentation.In addition, the side wall W10 of connected pathways T10 is provided at least one
Outlet opening P10, e.g. two or three, but not limited to this.It is in one embodiment, settable that there are four outlet opening P10.
Outlet opening P10 can for 1~5mm of width the elongated opening of 20~30mm of length, e.g. width 2.5mm and length 24mm
To the strip shaped opening of 25mm.When the subsequent progress debridement using debridement drill bit, it can will be removed by outlet opening P10
Tissue discharge out, to leave clean wound.
In addition, in another embodiment, the other end opposite with casing positioning column 220 can have on above-mentioned locating sleeve 200
There is a handle 230, held to provide user, to promote the convenience used.And above-mentioned it is set to connected pathways T10
The first location structure 210 on side wall W10 can be the guiding channel of length about 0.5~2mm, e.g. 1mm, to provide other
The function of surgical instrument contraposition, to ensure that multiple positioning columns 120 of above-mentioned repair of cartilage carrier 100 can be smoothly inserted into and closely sealed
It is pressed into the duck eye on os osseum.
Referring to Fig. 1 and Fig. 4 A, in one embodiment, an orientation angle 314A is provided on moulding knife 314.Orientation angle
The orientation angle 112 of 314A and repair of cartilage carrier 100, which can cooperate, to be aligned.Therefore, when repair of cartilage carrier 100 disposes
When in the region that moulding knife 314 is enclosed, it can be ensured that the orientation of repair of cartilage carrier 100 is in the subsequent side to be operated
Position.
Fig. 5 is the schematic diagram of the debridement drill bit of the operational tool group of one embodiment of the invention.Referring to Fig. 3 and Fig. 5,
In one embodiment, debridement drill bit 400 may pass through the connected pathways T10 of locating sleeve 200 to remove and be located at the to be implanted of patient
The cartilage in area, so that the affected part in patient is vacated for the position of the implantation such as repair of cartilage carrier 100 of Fig. 1.In another implementation
In example, debridement drill bit 400 has a stopper section 410.The size of stopper section 410 is greater than the size of connected pathways T10.Implement one
In example, the diameter of stopper section 410 is about 14~16mm, e.g. 15mm.Therefore, when debridement drill bit 400 passes through locating sleeve 200
Connected pathways T10 when, 410 meeting of stopper section limits debridement drill bit 400 so that debridement drill bit 400 can not continue forward
Debridement depth.For example, stopper section 410 makes the part of the prominent locating sleeve 200 of debridement drill bit 400 be 2mm, then debridement is bored
The depth of first 400 cartilages cut off also can be 2mm.In other words, the depth for the cartilage that debridement drill bit 400 is cut off is that cooperation is soft
The height of the ontology 110 of Bone Defect Repari carrier 100.
In another embodiment, the diameter at the lower drill with ferrule line position of debridement drill bit 400 is about 8 to 10mm, is that cooperation cartilage is repaired
The diameter of the ontology 110 of multiple carrier 100.It is sayed in more detail, and the diameter at the lower drill with ferrule line position of debridement drill bit 400 is no better than cartilage
The peripheral diameter of the ontology 110 of repair vector 100, to clean out the space for being suitble to accommodating repair of cartilage carrier 100.Due to debridement
Drill bit 400 can rotate in connected pathways T10, so there is no the first positioning of corresponding connected pathways T10 on debridement drill bit 400
The structure of structure 210.
Fig. 6 is the schematic diagram of the drilling instrument of the operational tool group of one embodiment of the invention.Referring to Fig. 3 and Fig. 6,
The drilling instrument 500 of the present embodiment is being located at the area to be implanted of patient to pass through the connected pathways T10 of locating sleeve 200
Multiple location holes (not being painted) is drilled out on os osseum.For example, drilling instrument 500 has more positioning columns 510, positioning column 510
The position of the location hole drilled out can corresponding diagram 1 repair of cartilage carrier 100 positioning column 120 position.For example, if it is fixed
The quantity of position column 120 is three, and three positioning columns 120 are 0 degree, 120 degree compared to the azimuth of the central axis of drilling instrument 500
With 240 degree, that is, three positioning columns 120 are the branches in a manner of point symmetry.The outer surface of positioning column 120 and center axis thereof
Angle be, for example, 3 degree to 5 degree, to drill out the location hole with slope.Specifically, because location hole has slope,
The positioning column 120 of repair of cartilage carrier 100 more gos deep into positioning hole, and location hole can more urgently catch positioning column 120, will
Repair of cartilage carrier 100 is secured firmly to the affected part of patient.
In addition, in another embodiment, drilling instrument 500 is for example with a third location structure 520, third location structure
The first mutually contraposition of location structure 210 of 520 and Fig. 3.Therefore, orientation meeting when drilling instrument 500 slides in outer tube 310
It is restricted, and then ensures that the position for the location hole that drilling instrument 500 drills out corresponds to the repair of cartilage carrier 100 of subsequent implantation
The position of positioning column 120.
Fig. 7 A to Fig. 7 G is to carry out repair of cartilage operation to pig using the cartilage repair systems of one embodiment of the invention
The photo in each stage.Please also refer to Fig. 7 A, select generally at pig as the object for establishing knee joint Minimally Invasive Surgery.Experimentation
In have recorded number including pig, about age, weight, gender and the relevant information in terms of operation and autopsy.Hand
Preoperative each pig needs first fasting 24 hours, and used anesthetic of performing the operation is 3%sodium pentobarbital, by rear leg
Injection, dosage is about 1mL/kg, and increases and decreases dosage depending on the anesthesia of each pig.After anesthesia to be confirmed, simultaneously by pig shaving
The place except operative site is covered with iodine disinfection, and with aseptic towel, only exposes joint position, is sterile to ensure to perform the operation
It is carried out under state.Then, about 3cm wound is cut in lateral cutaneous, exposing is intended to be implanted into cartilage as shown in Figure 1 after removing soft tissue
The position of repair vector 100.
Then Fig. 7 B is please referred to, locating sleeve 200 as shown in Figure 3 is placed on affected part, then by locating sleeve 200
Two casing positioning columns 220 are squeezed into and are fixed on affected part.Then Fig. 7 C is please referred to, push type instrument as shown in Figure 4 A is used
300 insertion locating sleeves 200 simultaneously cut out area A10 to be implanted in affected part with moulding knife.Then, it is bored using debridement as shown in Figure 5
First 400 are inserted into locating sleeve 200 and remove the cartilaginous tissue for being located at area A10 to be implanted.
Then Fig. 7 D is please referred to, drilling instrument 500 as shown in FIG. 6 is inserted into locating sleeve 200, and to be implanted being located at
Multiple location hole P20 as seen in figure 7e are drilled out on the os osseum of area A10.Then Fig. 7 F is please referred to, cartilage as shown in Figure 1 is repaired
Multiple carrier 100 is placed in area A10 to be implanted.It is that repair of cartilage carrier 100 is placed in wait plant in figure 7f in order to facilitate understanding
Enter by area A10, but is directly to be pushed away repair of cartilage carrier 100 using push type instrument 300 as shown in Figure 4 A when actual operation
Enter area A10 to be implanted.Since the shape of moulding knife is the shape of corresponding repair of cartilage carrier 100, and drilling instrument 500 and positioning
Also there is the location structure aligned mutually between casing 200, therefore the position of location hole P20 that drilling instrument 500 is drilled out can be straight
The positioning column 120 for connecing corresponding repair of cartilage carrier 100 can not only shorten operation institute without the step of additionally being aligned
The time needed, and successful surgery probability can be improved because precisely aligning.Fig. 7 G shows that repair of cartilage carrier 100 has been placed in wait plant
Enter area A10.
Fig. 8 is the schematic diagram of the usage mode of the repair of cartilage carrier of one embodiment of the invention.Fig. 8 is please referred to, cartilage is repaired
Multiple material is taken from patient itself, is especially taken from the non-cartilage by stress in joint, such as self soft with curet scraping
Bone.The self cartilage of above-mentioned taking-up is placed in the culture dish of 10cm, is shredded cartilage with scalpel, fragment size is with 20 hole mesh
To the control of 40 hole purpose sieves between 560-800 μm.The cartilage fragment of chopping is collected in the centrifuge tube of 15ml, and 5ml is added
Collagenase (collagenase), be placed in 37 DEG C of incubator, stand 1 hour, make part cartilage cell it is free go out
Come.Collagenase is placed in phosphate buffer solution (phosphate-buffered saline, PBS), and adjusts its ratio
Example is 2mg/ml PBS.It is placed in a centrifuge with the cartilage bone block after Collagenase separation dissolution, with revolving speed
1500r.p.m. is centrifuged 5 minutes, and Collagenase is separated with cartilage block.Cartilage fragment after centrifugation is clarified through absorbing
Collagenase supernatant (supernatant) after, remaining cartilage fragment and cell tissue are rinsed twice with PBS again, and
Centrifugation twice, the preparation of cartilage repair material is completed to remove remaining Collagenase.
Then, in the cartilage repair material merging 1c.c. injection needle tube aforementioned preparation completed, and cooperate No. 18 syringe needles
Preparation is completed cartilage repair material in a manner of injection and is placed on repair of cartilage carrier 100 by (18G).Later, repair of cartilage carries
Body 100 is one being put facing towards affected part to carry cartilage repair material, so that cartilage repair material directly contacts affected part.
Since cartilage repair material has certain toughness, it is not easy to drop out from repair of cartilage carrier.
Fig. 9 A and Fig. 9 B be respectively the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention and
Affected part photo after the reference examples performed the operation using traditional operation apparatus are recovered, surgical object is all such as above-mentioned pig.
Operational tool group it can be seen from Fig. 9 A using one embodiment of the invention performed the operation after 12 months, affected part is (as indicated with an arrow
Place) cartilage restore good, be hardly visible wound trace.Conversely, operator is carried out with traditional operation apparatus group, after 12 months
The cartilage recovery situation of affected part (such as at Fig. 9 B arrow meaning) is poor, and wound trace is obvious.
Figure 10 A and Figure 10 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part X-ray of the reference examples performed the operation using traditional operation apparatus after 6 months restore, surgical object is all as above-mentioned
Pig.Operational tool group it can be seen from Figure 10 A using one embodiment of the invention performed the operation after 6 months, affected part it is soft
Bone restores rapidly, wound depth only 2.8mm.Conversely, carrying out operator, the cartilage of affected part after 6 months with traditional operation apparatus group
Recovery is slower, and as shown in Figure 10 B, wound depth reaches 13.4mm.
Figure 11 A and Figure 11 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part sample photo of the reference examples performed the operation using traditional operation apparatus after 6 months restore, surgical object is all such as
Above-mentioned pig.Operational tool group it can be seen from Figure 11 A using one embodiment of the invention performed the operation after 6 months, affected part
The os osseum recovery of (locating as indicated with an arrow) is rapid, residue of only performing the operation a little, and cartilage restores well.Conversely, with traditional operation
Apparatus group carries out operator, and the os osseum recovery speed of affected part (such as at Figure 11 B arrow meaning) is slower after 6 months, and there are many operations
Residue.
Figure 12 A and Figure 12 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And affected part sample photo of the reference examples performed the operation using traditional operation apparatus after 12 months restore, surgical object is all such as
Above-mentioned pig.Operational tool group it can be seen from Figure 12 A using one embodiment of the invention performed the operation after 12 months, suffer from
The os osseum in portion (locating as indicated with an arrow) restores well, and almost without operation residue, and newborn hard bone tissue is grown into really.Instead
It, with traditional operation apparatus group carry out operator, after 12 months affected part (such as at Figure 12 B arrow meaning) os osseum restore situation compared with
Difference still has many operation residues.
Figure 13 A and Figure 13 B be the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention respectively with
And the stained slice of the affected part using the reference examples that traditional operation apparatus is performed the operation after recovered, surgical object are all as above-mentioned
Pig.Figure 13 A and Figure 13 B is using sarranine (Safranin-O) and fast green (Fast Green FCF) while to be dyed,
Situation is restored further to inspect cartilage proliferation situation and os osseum.
Referring to Figure 13 A and Figure 13 B, one embodiment of the invention is used it can be seen from the pigmented section of sarranine
Operational tool group performed the operation after 12 months, as in Figure 13 A at upper arrow meaning, cartilage proliferation in order, and is used and is passed
Operational tool group of uniting carries out operator, as at upper arrow meaning, cartilage proliferation situation is common in Figure 13 B.On the other hand, by solid
Green pigmented section can be seen that performed the operation using the operational tool group of one embodiment of the invention after 12 months, in Figure 13 A
At middle arrow meaning, os osseum restores in order, and traditional operation apparatus group is used to carry out operator, among in Figure 13 B
At arrow meaning, os osseum is almost without hyperplasia.
Figure 14 is the experimental example performed the operation using the cartilage repair systems of one embodiment of the invention and the traditional hand of use
The quantization figure of the wound width for the reference examples that art apparatus is performed the operation.Figure 14 is please referred to, the operation of one embodiment of the invention is used
The wound width of the experimental example that apparatus group is performed the operation half a year after surgery is only pair performed the operation using traditional operation apparatus
The 60% of the wound width of half a year after surgery as usual, and wound width of the previous experiments example in latter year of performing the operation is about reference examples
In the 50% of the wound width in latter year of performing the operation.
In conclusion in repair of cartilage carrier of the invention, the operational tool group and cartilage repair systems arranged in pairs or groups, it is soft
Bone Defect Repari carrier use cellular structure, facilitate between new and old cartilaginous tissue gap fusion, and operational tool group make it is micro-
Wound repair of cartilage operation is possibly realized.In addition, promotion cartilage can be carried when repair of cartilage carrier uses biodegradable material
Repair of cartilage carrier is accurately positioned and is implanted into minimally invasive mode by the substance of reparation, orientable operational tool group of arranging in pairs or groups
The affected part of patient.In this way, cartilage regeneration defect can be assisted in the case where destroying lesser situation to os osseum, and completed repairing
Repair of cartilage carrier natural decomposition and can be metabolized in vivo afterwards.
Although disclosing the present invention in conjunction with above embodiments, it is not intended to limit the invention, any affiliated technology
Have usually intellectual in field, without departing from the spirit and scope of the present invention, can make some changes and embellishment, therefore this hair
Bright protection scope should be subject to what the appended claims were defined.
Claims (15)
1. a kind of repair of cartilage carrier characterized by comprising
Ontology is cellular structure, to carry cartilage repair material；And
Multiple positioning columns, respectively one end of the positioning column is fixed to the ontology, os osseum of the other end to be inserted into patient.
2. repair of cartilage carrier as described in claim 1, wherein the material of the ontology is biodegradable material.
3. repair of cartilage carrier as described in claim 1, wherein the material of the ontology is polylactic acid, polyglycolic acid, gathers in oneself
Ester, polyvinyl alcohol, poly (hydroxyalkanoate) or at least two above-mentioned polymer copolymer.
4. repair of cartilage carrier as described in claim 1, wherein the porosity of the cellular structure is 50%~90%.
5. repair of cartilage carrier as described in claim 1, wherein the periphery of the ontology has orientation angle.
6. a kind of operational tool group characterized by comprising
Locating sleeve has connected pathways, wherein has the first location structure on the side wall of the connected pathways；And
Push type instrument, including outer tube and push rod wherein have the second location structure, the outer tube on the outer wall of the outer tube
To pass through the connected pathways of the locating sleeve, and second location structure is mutually aligned with first location structure, this is pushed away
Bar is slidably disposed in the outer tube, and one end of the outer tube has moulding knife, to cut out on the affected part of patient to
Implantation region.
7. operational tool group as claimed in claim 6, wherein one end of the locating sleeve has multiple casing positioning columns, to
It is inserted into the affected part of the patient.
8. operational tool group as claimed in claim 7, wherein the other end of the locating sleeve has handle, with for user
It holds.
9. operational tool group as claimed in claim 6, wherein the side wall of the connected pathways is additionally provided with outlet opening.
10. operational tool group as claimed in claim 6, wherein the moulding knife has orientation angle.
11. operational tool group as claimed in claim 6 further includes debridement drill bit, this to pass through the locating sleeve runs through
Channel and remove the cartilage positioned at the area to be implanted of the patient.
12. operational tool group as claimed in claim 11, wherein the debridement drill bit has stopper section, and the size of the stopper section is big
In the connected pathways size and the debridement depth to limit the debridement drill bit.
13. operational tool group as claimed in claim 6, further includes drilling instrument, this to pass through the locating sleeve runs through
Channel and be located at the patient the area to be implanted os osseum on drill out multiple location holes.
14. operational tool group as claimed in claim 13, wherein the drilling instrument has third location structure, third positioning
Structure is mutually aligned with first location structure.
15. a kind of cartilage repair systems characterized by comprising
Repair of cartilage carrier, including ontology and multiple positioning columns, wherein the ontology is cellular structure and repairs to carry cartilage
Multiple material, respectively one end of the positioning column is fixed to the ontology and respectively os osseum of the other end of the positioning column to be inserted into patient；
Locating sleeve has connected pathways, wherein has the first location structure on the side wall of the connected pathways；And
Push type instrument, including outer tube and push rod wherein have the second location structure, the outer tube on the outer wall of the outer tube
To pass through the connected pathways of the locating sleeve, and second location structure is mutually aligned with first location structure, this is pushed away
Bar is slidably disposed in the outer tube, and one end of the outer tube has moulding knife, to cut out on the affected part of the patient
The shape in area to be implanted, the area to be implanted corresponds to the shape of the ontology.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711463451.9A CN109966029A (en) | 2017-12-28 | 2017-12-28 | Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems |
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| CN201711463451.9A CN109966029A (en) | 2017-12-28 | 2017-12-28 | Repair of cartilage carrier, the operational tool group arranged in pairs or groups and cartilage repair systems |
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Application publication date: 20190705 |