CN109960182A - A kind of signal generation apparatus and the equipment with signal generation apparatus - Google Patents
A kind of signal generation apparatus and the equipment with signal generation apparatus Download PDFInfo
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- CN109960182A CN109960182A CN201711402381.6A CN201711402381A CN109960182A CN 109960182 A CN109960182 A CN 109960182A CN 201711402381 A CN201711402381 A CN 201711402381A CN 109960182 A CN109960182 A CN 109960182A
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- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 title claims abstract description 65
- 230000003321 amplification Effects 0.000 claims abstract description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 15
- 230000005611 electricity Effects 0.000 claims description 7
- 230000000638 stimulation Effects 0.000 abstract description 15
- 230000004438 eyesight Effects 0.000 abstract description 10
- 210000000857 visual cortex Anatomy 0.000 abstract description 4
- 230000004044 response Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000005424 photoluminescence Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 230000000007 visual effect Effects 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 201000009487 Amblyopia Diseases 0.000 description 1
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- 208000013935 Electric injury Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000035719 Maculopathy Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000596297 Photis Species 0.000 description 1
- 201000007737 Retinal degeneration Diseases 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
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- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000004315 low visual acuity Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
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- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
- G05B19/0423—Input/output
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- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/20—Pc systems
- G05B2219/25—Pc structure of the system
- G05B2219/25257—Microcontroller
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- Engineering & Computer Science (AREA)
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Abstract
The present invention is suitable for biomedical engineering technology field, provides a kind of signal generation apparatus with the equipment with signal generation apparatus, which includes: pulse signal parameter input interface, for receiving externally input pulse signal parameter；Pulse signal generating unit to receive the pulse signal parameter, and can produce the voltage signal with corresponding frequencies value；Single bipolarity switch unit receives the voltage signal, forms mono-/bis-polar voltages signal；Voltage power amplifying unit, for will be exported after mono-/bis-polar voltages signal amplification.Pass through single bipolar signal switch unit, externally the higher frequency electrical stimulation signal changed can be replaced by output polarity, realize charging neutrality, reduce stimulus threshold, deeper into vision system is applied to, visual cortex response is induced, and use for a long time is avoided to cause to burn, keep whole device safer, user is made to obtain better usage experience.
Description
Technical field
The invention belongs to biomedical engineering technology field more particularly to a kind of signal generation apparatus and there is signal hair
The equipment of generating apparatus.
Background technique
The mankind externally in the information of the understanding about 90% in the world are provided by vision, and normal complete vision is to produce in this way
Raw: on the retina by extraneous image objects, the photosensory cell on retina turns picture signal to the optical system of eyes
Bioelectrical signals are changed to, brain view skin is then transmitted to by optic nerve fiber after cell neural network carries out preliminary treatment
Layer, brain visual cortex handle the bioelectrical signals of acquisition again and perceive generation vision.Any one of pathways for vision
Link is damaged or lesion can all lead to serious visual problem, such as: retinal pigment degeneration, maculopathy, low visual acuity,
Moderate and severe degree of amblyopia etc..
Research finds to carry out electro photoluminescence by the vision system to human body, so that visual cortex is generated similar light stimulation based retinal and draw
The excitement of hair can induce effective optical illusion, bring hope to treat above-mentioned visual problem.But existing implantable scheme
The main output low frequency section single polarity of electrical stimulation signal occurrence of equipment electro photoluminescence, more by restraining factors, there are electric injuries
Etc. problems, also need for quite a long time, just can enter clinical application.
Summary of the invention
The embodiment of the present invention provides a kind of signal generation apparatus, it is intended to generate mono-/bis-polar stimulation signal.
The embodiments of the present invention are implemented as follows, a kind of signal generation apparatus characterized by comprising
Pulse signal parameter input interface, for receiving externally input pulse signal parameter；
Pulse signal generating unit to receive the pulse signal parameter, and can produce the electricity with corresponding frequencies value
Press signal；
Single bipolarity switch unit receives the voltage signal, forms mono-/bis-polar voltages signal；
Voltage power amplifying unit, for will be exported after mono-/bis-polar voltages signal amplification.
The present invention also provides a kind of equipment with signal generation apparatus, the equipment includes:
Signal generation apparatus, the signal generation apparatus are as described above；
Pulse signal input unit is used for the signal generation apparatus input pulse parameter；
Electrode connects with single bipolar signal switch unit of the signal generation apparatus, to export stimulus signal.
Signal generation apparatus provided by the invention, impulse generating unit can generate voltage signal according to pulse signal parameter,
Single bipolarity switch unit can receive the voltage signal, and form mono-/bis-polar voltages signal, mono-/bis-polar voltages signal warp
It is exported after the amplification of voltage power amplifying unit.By single bipolar signal switch unit, externally output polarity can alternately change
Electrical stimulation signal, may be implemented charging neutrality, reduce stimulus threshold, use for a long time is avoided to cause the problems such as burning.And energy
It realizes that polarity, the frequency of electro photoluminescence are adjustable and output voltage is constant, and then obtains better optical illusion effect.
Detailed description of the invention
Fig. 1 is the functional block diagram of signal generation apparatus provided in an embodiment of the present invention；
Fig. 2 is the partial circuit diagram of polarity of voltage switching module provided in an embodiment of the present invention；
Fig. 3 is the functional block diagram of the equipment of signal generation apparatus provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Signal generation apparatus provided by the invention passes through pulse signal generating unit, single bipolarity switch unit, Yi Ji electricity
Pressure power amplification unit is used cooperatively, and the electrical stimulation signal that can produce signal generation apparatus is with different polarity and surely
Fixed voltage externally exports.
Specific implementation of the invention is described in detail below in conjunction with specific embodiment.
As shown in Figure 1, in embodiment provided by the invention, which includes:
Pulse signal parameter input interface, for receiving externally input pulse signal parameter, as pulse signal frequency,
The amplitude of pulse signal, the duration of pulse signal, the time interval of train of pulse, polarity control signal and signal duty
Than etc.；Pulse signal generating unit to receive above-mentioned pulse signal parameter, and can produce the voltage with corresponding frequencies value
Signal；Single bipolarity switch unit receives voltage signal, forms mono-/bis-polar voltages signal；Voltage power amplifying unit is used
It is exported after by the amplification of mono-/bis-polar voltages signal.In the present embodiment, the electrical stimulation signal that signal generation apparatus generates is (i.e.
Amplified mono-/bis-polar voltages signal) vision system that can be used for stimulating people, it makes one to generate optical illusion, it can be fast and effective
Check (EEP) and treatment visual problem.In addition, the electrical stimulation signal that signal generation apparatus generates can pass through in the present embodiment
Body surface exciting human vision system can externally the electric of output polarity alternating variation be pierced by single bipolar signal switch unit
Charging neutrality may be implemented in energizing signal, avoids use for a long time from causing the problems such as burning, keeps whole device safer, uses
Family obtains better usage experience.Bipolar signal can induce vision skin under lower stimulated current intensity compared with unipolar signal
Layer response.
In embodiment provided by the invention, pulse signal generating unit is for being converted to the pulse parameter that user inputs
The generation of corresponding digital signal, digital signal has corresponding frequency, and pulse signal generating unit can use MCU
(Microcontroller Unit, i.e. micro-control unit) and FPGA (Field-Programmable Gate Array, i.e., it is existing
Field programmable gate array) combination, DSC chip (Digital Signal Processing, i.e. digital signal processing chip),
FPGA or other embeded processors (such as ARM, application specific processor) are one such.Below with pulse signal generating unit
For present invention is described for FPGA.
Single bipolarity switch unit can use combination or the number current potential of DAC module and polarity of voltage switching module
Device.When single bipolarity switch unit uses DAC and polarity of voltage switching module, the voltage signal that FPGA is generated is (for number letter
Number) through DAC analog voltage signal being converted to, these analog voltage signals are converted to mono-/bis-pole by polarity of voltage switching module
Property voltage signal.
Specifically, polarity of voltage switching module includes: the reverse phase scaling circuit to connect with the output end of DAC module；
And the reverse phase ratio add circuit to connect with the output end of reverse phase scaling circuit.
As shown in Fig. 2, reverse phase scaling circuit includes an operational amplifier Q1, the negative input of operational amplifier Q1
It is electrically connected with the output end of DAC module, is in series with resistance R therebetweenA, the positive input ground connection of operational amplifier Q1,
Resistance R in parallel between the reverse input end of operational amplifier Q1 and output endB, it is assumed that input voltage V1, output voltage are
V2, then V2=- (RB/RA) * V1, in the present embodiment, setting RA=RB, then V2=-V1.Reverse phase ratio add circuit includes
The negative input of one operational amplifier Q2, operational amplifier Q2 connect with the output end of operational amplifier Q1, go here and there therebetween
Join a resistance RC, the positive input ground connection of operational amplifier Q2, between the reverse input end and output end of operational amplifier Q2
One resistance R of parallel connectionD, the negative input of operational amplifier Q2 is also electrically connected with a voltage source VCC, is in series with electricity therebetween
Hinder RE, it is assumed that the output voltage of reversed ratio add circuit is V0, then V0=- [(RD/RE)*VCC+(RD/RC) * V2], it is assumed that RD
=RE=2*RC, then, output voltage may be implemented by changing the size of V1 in V0=- (VCC+2*V2)=- VCC+2*V1
The mono-/bis-polarity switching of signal V0.
It should be understood that polarity of voltage switching module can also use other in other embodiments provided by the invention
Circuit with polarity switching function, don't explain too much here by the present invention.
When single bipolarity switch unit uses digital regulation resistance, digital current potential can be directly controlled by impulse generating unit
Device generates required voltage signal.
In embodiment provided by the invention, voltage power amplifying unit includes voltage power amplifier, to amplify Dan Shuan
The mono-/bis-polar voltages signal of polarity switched cell output.In addition the amplification factor of voltage power amplifier can directly by
FPGA control is big in order to the electrical stimulation signal voltage that is exported according to the pulse parameter of input come adjustment signal generating device
It is small.Since voltage power amplifier amplification factor is higher, manufacturing cost is higher, in order to reduce cost, provided by the invention
Power amplification unit further includes having second level amplification module, such as transformer in embodiment.
Frequency 1000Hz pulse electrical signal below is medically referred to as low frequency electrical signal or low frequency pulse signal,
1000Hz-l00kHz is intermediate frequency electric signal, and the above are high frequency electrical signals by l00kHz.In addition, medically, electro photoluminescence can be divided into plant
Enter formula and non-built-in mode, when using implanted electrode, it is high that low frequency electrical signal just can be such that patient (or other receptors, similarly hereinafter) generate
The optical illusion effect of spatial resolution, but when using non-built-in mode electrode, low frequency electrical signal can't effectively meet patient
The demand of (or medical experiment) to optical illusion effect.So being mentioned to enhance the applicability of this signal generation apparatus in the present invention
In the embodiment of confession, signal generation apparatus further include: electronic switch, control terminal and the pulse signal generating unit phase of electronic switch
It connects, input terminal connects with single bipolarity switch unit, and output end connects with voltage power amplifying unit；Electronic switch is low in frequency
It when given threshold, is held on, when frequency is higher than the given threshold, the electronics is controlled by pulse signal generating unit
It switches on-off.That is, it needs to output electrical stimulation signal frequency be lower than given threshold when (such as 7000HZ), pulse signal
Generating unit can directly generate the voltage signal of corresponding frequencies, when the frequency for the electrical stimulation signal for needing to export is greater than setting
When threshold value, by the on-off for the frequency control signal control electronic switch that pulse signal generating unit generates, electricity thorn is exported to realize
The high-frequency of energizing signal changes.By electronic switch, signal generation apparatus can be made to generate the two-way electro photoluminescence letter of higher frequency
Number, conducive to electrical stimulation signal deeper into vision system is acted on, when making using non-built-in mode electrode, it is unreal also to obtain required light
Visual effect fruit.
In embodiment provided by the invention, signal generation apparatus is additionally provided with feedback unit, i.e. pulse signal generating unit
Output end draws the input terminal of a feedback signal line to pulse signal generating unit, when the pulse signal of reality output and pulse are believed
The pulse parameter that number generating unit receives can be automatically corrected adjusting, real output value is made to reach input there are when deviation
Pulse parameter values.In addition, signal generation apparatus can also be made to carry out self-test by feedback unit: when defeated to signal generation apparatus
After entering pulse parameter signal, the input terminal of pulse signal generating unit is not obtained from pulse signal generating unit output end feedback
Signal, or the pulse parameter deviation of signal that obtained feedback signal and pulse signal generating unit receive is larger that (pulse is believed
Number generating unit prestores the range of tolerance), then it is assumed that signal generation apparatus error is unable to normal use, further may be used
The devices such as display device or voice output are set on signal generation apparatus exporting error signal to user.
In actual use, since the impedance of different patients is different, so in embodiment provided by the invention, letter
Number generating device is additionally provided with the test cell for Impedance measurement, joins convenient for corresponding pulse is arranged according to patent impedance's size
Number keeps the use of patient safer, and can obtain better optical illusion effect.For example, when using non-implant electrode, mainly
Make user preferably according to the impedance of patient skin to check whether sufficiently conducting and adjust corresponding output voltage
With experience.
It should be understood that the detected value of impedance unit can also be passed through number display, voice output by signal generation apparatus
Etc. modes export to user, so that user voluntarily adjusts the pulse signal parameter of input.
The present invention also provides a kind of equipment with signal generation apparatus, as shown in figure 3, the equipment includes: as above-mentioned
Signal generation apparatus described in embodiment；Pulse signal input unit is used for signal generation apparatus input pulse parameter；Electricity
Pole connects with signal generation apparatus, to export stimulus signal.The wherein pulse of pulse signal input unit and signal generation apparatus
Signal parameter input interface connects, and electrode connects with the power amplification unit output end of signal generation apparatus.This equipment can root
According to the setting of user, the electrical stimulation signal of different frequency, polarity and voltage swing is exported to patient, generates patient better
Optical illusion effect.
In the present embodiment, pulse signal input unit can be host computer, such as computer, directly connect and believed by connection
The pulse signal parameter input interface of number generating device, pulse signal input unit can also directly be one and signal generation apparatus
The keyboard to connect, pulse signal input unit can also be the equipment wirelessly to connect with signal generation apparatus.For example, sharp
Connected by the modes such as bluetooth, WIFI, ZigBee with pulse signal generation device direct communication with mobile terminal, it is possible to understand that
, this equipment is additionally provided with wireless communication device at this time.
In embodiment provided by the invention, pulse signal input unit includes touch screen, can touched according to user
It touches the waveform drawn on screen or several phase points automatically generates pulse parameter, more conducively more preferably optical illusion generates experimental exploring
Scheme.
In embodiment provided by the invention, the input interface of pulse signal input unit includes the input of several parameters
Frame, such as the frequency of pulse signal, the amplitude of pulse signal, the duration of pulse signal, the time interval of train of pulse and pole
Property control signal etc., user can input corresponding parameter in each input frame, in order to experimental implementation, be conducive to explore more preferably light
Photis generates scheme.
Further, in embodiment provided by the invention, several group pulse ginsengs are prestored in pulse signal input unit
Number, each group of parameter can correspond to a kind of scheme, in use, user can directly select according to required therapeutic scheme, nothing
The parameters of the input program need to be remembered, it is simple to operate, better usage experience is brought to user, this specific equipment
On be provided with different function buttons, each function button can correspond to a kind of scheme.
In embodiment provided by the invention, electrode includes implanted electrode and non-built-in mode electrode.Non-built-in mode electrode
It can be common patch type electrode, hand-held electrode, be also possible to wearable electrode, such as the structure in similar frame
Upper setting electrode, can satisfy the demand of different patients in this way.In addition, electrode replaceable be installed on the electricity of signal generation apparatus
Stimulate output port, the use of more convenient user.Preferably, in embodiment provided by the invention, above-mentioned patch
Formula electrode, hand-held electrode, wearable electrode are mono-/multi- contact electrode.The visual cortex response space point of single contact electrode-induced
Cloth range increases with electric current and is increased, with uniformity and stability；Multi-contact electrode can be induced along the stimulation site visual field
The optical illusion of distribution responds, and has certain space correspondence；It can be applied in combination as needed, to enhance electrical stimulating effect.Into
One step, this equipment is additionally provided with the control device of control contact electrode opening and closing, different to select for different patient demands
Electrode contacts or the electrode contacts of different number carry out electro photoluminescence.
In conclusion signal generation apparatus provided by the invention is single by pulse signal generating unit, single bipolarity switching
First and constant-current source to be used cooperatively, the electro photoluminescence for generating signal generation apparatus is externally exported with different polarity, is mentioned
High electrical stimulating effect, meanwhile, this signal generation apparatus also includes electronic switch, this signal generation apparatus is allow to export height
The electrical stimulation signal of frequency.Furthermore the present invention also provides a kind of equipment with signal generation apparatus, which has used above-mentioned
Signal generation apparatus, allow this equipment to export the electro photoluminescence of different frequency, polarity and voltage swing to patient, improve
Optical illusion effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (14)
1. a kind of signal generation apparatus characterized by comprising
Pulse signal parameter input interface, for receiving externally input pulse signal parameter；
Pulse signal generating unit to receive the pulse signal parameter, and can produce the voltage letter with corresponding frequencies value
Number；
Single bipolarity switch unit receives the voltage signal, forms mono-/bis-polar voltages signal；
Voltage power amplifying unit, for will be exported after mono-/bis-polar voltages signal amplification.
2. signal generation apparatus as described in claim 1, which is characterized in that the pulse signal generating unit be MCU with
The combination of FPGA/one of FPGA/DSP chip or embeded processor.
3. signal generation apparatus as described in claim 1, which is characterized in that the list bipolarity switch unit is DAC module
Combination or digital regulation resistance with polarity of voltage switching module.
4. signal generation apparatus as claimed in claim 3, which is characterized in that the polarity of voltage switching module includes:
The reverse phase scaling circuit to connect with the output end of the DAC module；And
The reverse phase ratio add circuit to connect with the output end of the reverse phase scaling circuit.
5. signal generation apparatus as described in claim 1, which is characterized in that the voltage power amplifying unit includes voltage function
Rate amplifier.
6. signal generation apparatus as claimed in claim 5, which is characterized in that the power amplification unit further includes and the electricity
The second level amplification module that pressure power amplification unit output end connects.
7. signal generation apparatus as claimed in claim 6, which is characterized in that the second level amplification module includes transformer.
8. signal generation apparatus as described in claim 1, which is characterized in that the signal generation apparatus further include:
Electronic switch, the control terminal of the electronic switch connect with the pulse signal generating unit, input terminal and the Dan Shuan
Polarity switched cell connects, and output end connects with the voltage power amplifying unit；
The electronic switch is held on when frequency is lower than given threshold, when frequency is higher than the given threshold, by described
Pulse signal generating unit controls the on-off of the electronic switch.
9. a kind of equipment with signal generation apparatus, which is characterized in that the equipment includes:
Signal generation apparatus, the signal generation apparatus is as described in claim 1~8 any one；
Pulse signal input unit is used for the signal generation apparatus input pulse parameter；
Electrode connects with the bipolar signal switch unit of the signal generation apparatus, to export stimulus signal.
10. as claimed in claim 9 with the equipment of signal generation apparatus, which is characterized in that the pulse signal input dress
It sets including host computer, keyboard or other equipment to be connected in a manner of wire/wireless with the signal generating unit.
11. as claimed in claim 9 with the equipment of signal generation apparatus, which is characterized in that the pulse signal input dress
It sets with touch screen, the pulse signal can be automatically generated according to the waveform drawn on the touch screen or several phase points
Parameter.
12. as claimed in claim 9 with the equipment of signal generation apparatus, which is characterized in that the electrode includes implanted
Electrode and non-built-in mode electrode.
13. as claimed in claim 12 with the equipment of signal generation apparatus, which is characterized in that the non-built-in mode electrode is
Patch type electrode, hand-held electrode or wearable electrode.
14. as claimed in claim 13 with the equipment of signal generation apparatus, which is characterized in that the patch type electrode, hand
Hold formula electrode, wearable electrode is mono-/multi- contact electrode.
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