CN109827941B - Convex high-flux high-repeatability substrate structure - Google Patents
Convex high-flux high-repeatability substrate structure Download PDFInfo
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- CN109827941B CN109827941B CN201811620766.4A CN201811620766A CN109827941B CN 109827941 B CN109827941 B CN 109827941B CN 201811620766 A CN201811620766 A CN 201811620766A CN 109827941 B CN109827941 B CN 109827941B
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Abstract
The invention discloses a convex high-flux high-repeatability base structure, wherein a plurality of detection grooves are formed in the top of a substrate, a boss is arranged at the bottom of each detection groove, the outer wall of each boss and the inner wall of each detection groove are arranged at intervals, a partition structure is arranged at the top of each boss, a plurality of base containing positions which are arranged in an isolated mode are formed in the top of each boss through the partition structure, and a detection base is arranged on each base containing position. Through the high repeatability basement structure of convex style of calligraphy high flux of above-mentioned optimal design, design through a plurality of recesses, realize the high flux detection of sample in batches, and through the design of recess cooperation boss, the excessive liquid sample of dropwise add on detecting the basement of being convenient for can flow in the clearance of boss periphery, accelerate liquid sample to volatilize, reduce drying time, in addition, the boss top sets up the detection basement of a plurality of isolations, same sample detects on a plurality of bases when being convenient for detect, greatly reduced detection error, improve the reliability of testing result.
Description
Technical Field
The invention relates to the field of surface enhanced Raman spectroscopy, in particular to a convex high-flux high-repeatability substrate structure.
Background
With the development of socioeconomic, the problem of drug abuse seriously harms the social stability. Various conventional methods (such as chromatography, mass spectrometry and the like) for analyzing and detecting drugs in biological detection materials require complex sample pretreatment processes, are complex to operate, and are difficult to detect a large number of samples simultaneously. Therefore, the rapid high-flux detection technology of the drug molecules in the biological detection materials is always a difficult problem.
In recent years, the Surface Enhanced Raman Spectroscopy (SERS) technology has been developed rapidly, and mainly has the following characteristics: 1) SERS can provide molecular level fingerprinting; 2) SERS can greatly enhance Raman signals and can realize trace or even single molecule detection. These advantages make the SERS technology have great potential for application in the field of drug detection.
Although the SERS technology has a good application prospect in drug detection, due to the limitation of a substrate, the current SERS technology generally prepares a SERS substrate in the drug detection field for detection of a sample, and high-throughput detection of a large number of samples is difficult to realize.
Disclosure of Invention
In order to solve the technical problems in the background art, the invention provides a convex high-flux high-repeatability substrate structure.
The invention provides a convex high-flux high-repeatability substrate structure, which comprises: a substrate;
the substrate top is equipped with a plurality of detection recesses, and every detection recess bottom is equipped with the boss, the boss outer wall with detect the interval setting between the recess inner wall, the boss top is equipped with and cuts off the structure, cuts off the structure and forms a plurality of basement that keep apart each other and arrange at the boss top and hold the position, and every basement holds and is equipped with the detection basement on the position.
Preferably, the partition structure comprises at least one vertically arranged partition.
Preferably, the baffles on the plurality of bosses are arranged in parallel.
Preferably, the partition structure includes a plurality of partition plates arranged in parallel, and the plurality of partition plates form a plurality of substrate receiving locations arranged in sequence in a direction perpendicular to the partition plates at the tops of the bosses.
Preferably, the partition structure comprises a plurality of partitions arranged radially along the circumference, and the plurality of partitions form a plurality of substrate receiving positions distributed along the circumference on the tops of the bosses.
Preferably, the detection substrate comprises a substrate carrier and detection nanostructure elements disposed on the substrate carrier.
Preferably, the substrate carrier is a glass sheet, a silicon sheet, or a semiconductor sheet.
Preferably, the detection substrate is fixed to said substrate receiving site by chemical adhesion.
Preferably, the plurality of detection grooves are uniformly distributed on the substrate.
Preferably, the detection substrate is located below the plane of the opening of the detection recess.
According to the convex high-flux high-repeatability base structure, the top of a substrate is provided with a plurality of detection grooves, the bottom of each detection groove is provided with a boss, the outer wall of each boss and the inner wall of each detection groove are arranged at intervals, the top of each boss is provided with a partition structure, the partition structure forms a plurality of base containing positions which are arranged in an isolated mode on the top of each boss, and each base containing position is provided with a detection base. Through the high repeatability basement structure of convex style of calligraphy high flux of above-mentioned optimal design, design through a plurality of recesses, realize the high flux detection of detecting the sample in batches, and through the design of recess cooperation boss, the excessive liquid sample of the dropwise add on detecting the basement of being convenient for can flow in the clearance of boss periphery, accelerate liquid sample volatilizees, reduce drying time, furthermore, the boss top sets up the detection basement of a plurality of isolations, same sample detects on a plurality of bases when being convenient for detect, greatly reduced detection error, the reliability of testing result is improved.
Drawings
Fig. 1 is a schematic top view of a high-throughput and high-repeatability substrate structure in a raised shape according to the present invention.
FIG. 2 is a schematic side view of a high-throughput high-repeatability substrate structure in raised form according to the present invention.
Detailed Description
As shown in fig. 1 and 2, fig. 1 is a schematic structural diagram of a convex high-throughput high-repeatability substrate structure provided by the present invention, and fig. 2 is a schematic structural diagram of a side view of a convex high-throughput high-repeatability substrate structure provided by the present invention.
Referring to fig. 1 and 2, the invention provides a convex high-flux high-repeatability substrate structure, comprising: a substrate 1;
the top of the substrate 1 is provided with a plurality of detection grooves, the bottom of each detection groove is provided with a boss 2, the outer wall of each boss 2 and the inner wall of each detection groove are arranged at intervals, the top of each boss 2 is provided with a partition structure, the partition structure forms a plurality of base containing positions which are separated from each other at the top of each boss 2, and each base containing position is provided with a detection base 4.
In the specific working process of the convex high-flux high-repeatability base structure, during detection, samples to be detected are placed on the multiple detection bases in each groove, then the whole substrate is placed on the detection station, and the samples on each detection base are detected one by one.
In this embodiment, the high repeatability basement structure of convex style of calligraphy high flux that provides, the substrate top is equipped with a plurality of detection recesses, and every detection recess bottom is equipped with the boss, the boss outer wall with interval sets up between the detection recess inner wall, and the boss top is equipped with cuts off the structure, cuts off the structure and forms a plurality of basement that keep apart each other and arrange at the boss top and holds the position, and every basement holds and is equipped with the detection basement on the position. Through the high repeatability basement structure of convex style of calligraphy high flux of above-mentioned optimal design, design through a plurality of recesses, realize the high flux detection of detecting the sample in batches, and through the design of recess cooperation boss, the excessive liquid sample of the dropwise add on detecting the basement of being convenient for can flow in the clearance of boss periphery, accelerate liquid sample volatilizees, reduce drying time, furthermore, the boss top sets up the detection basement of a plurality of isolations, same sample detects on a plurality of bases when being convenient for detect, greatly reduced detection error, the reliability of testing result is improved.
In a specific embodiment, the partition structure comprises at least one partition plate 3 which is vertically arranged, the partition plate is vertically arranged on the boss to form two substrate accommodating positions, and the detection samples on two sides are isolated through the partition plate.
In the specific arrangement mode of the partition boards, the partition boards 3 on the plurality of bosses 2 are arranged in parallel, so that samples in the plurality of grooves can be detected in sequence.
In one arrangement mode of the partition structure, the partition structure comprises a plurality of partition plates 3 which are arranged in parallel, and the plurality of partition plates 3 form a plurality of substrate accommodating positions which are sequentially arranged in a direction perpendicular to the partition plates 3 at the tops of the bosses 2.
In another arrangement of the partition structure, the partition structure comprises a plurality of partition plates 3 radially arranged along the circumference, and the plurality of partition plates 3 form a plurality of substrate accommodating positions distributed along the circumference on the top of the boss 2.
In a specific embodiment of the detection substrate, the detection substrate 4 comprises a substrate carrier and detection nanostructure elements disposed on the substrate carrier; in a specific processing mode of the detection substrate, the nano particles are assembled on a large-area substrate carrier to obtain a large-area SERS detection substrate, and then the small-area SERS detection substrate is obtained in a laser cutting mode, so that high repeatability of SERS detection is realized.
In the material selection of the substrate carrier, a glass sheet, a silicon sheet or a semiconductor sheet is adopted as the substrate carrier, and preferably, the silicon sheet is selected as the substrate carrier.
In a specific arrangement of the detection substrate, the detection substrate 4 is fixed to the substrate receiving site by chemical adhesion.
In other embodiments, the plurality of detection grooves are uniformly distributed on the substrate 1.
In order to prevent interference between different detection samples in adjacent detection grooves, the detection substrate 4 is positioned below the plane where the openings of the detection grooves are positioned, so that the samples are positioned in the detection grooves during detection.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. A raised high-throughput high-repeatability substrate structure, comprising: a substrate (1);
substrate (1) top is equipped with a plurality of detection recesses, and every detection recess bottom is equipped with boss (2), boss (2) outer wall with the interval sets up between the detection recess inner wall, and boss (2) top is equipped with cuts off the structure, cuts off the structure and forms a plurality of bases of keeping apart each other and arranging at boss (2) top and hold the position, and every base holds and is equipped with detection base (4) on the position.
2. Embossed high flux high repeatability foundation structure according to claim 1, characterized by the partition structure comprising at least one vertically arranged partition (3).
3. Embossed high throughput high repeatability substrate structure according to claim 2, characterized in that the partitions (3) on a plurality of bosses (2) are arranged in parallel.
4. A raised high throughput high repeatability substrate structure according to claim 2 wherein the partition structure comprises a plurality of parallel arranged partitions (3), the plurality of partitions (3) forming a plurality of substrate receiving locations on top of the raised platform (2) arranged in series in a direction perpendicular to the partitions (3).
5. A raised high throughput high repeatability substrate structure according to claim 2 wherein the partition structure comprises a plurality of partitions (3) radially arranged along the circumference, the plurality of partitions (3) forming a plurality of substrate receiving locations circumferentially distributed on top of the raised platform (2).
6. Embossed high-throughput high-reproducibility substrate structure according to claim 1, characterized in that the detection substrate (4) comprises a substrate carrier and detection nanostructure elements arranged on the substrate carrier.
7. Embossed high throughput high reproducibility substrate structure according to claim 1, wherein the detection substrate (4) is fixed on the substrate receiving position by chemical adhesion.
8. Embossed high-throughput high-reproducibility base structure according to claim 1, characterized in that a plurality of detection grooves are evenly distributed on the substrate (1).
9. Raised high-throughput high-reproducibility substrate structure according to claim 1, wherein the detection substrate (4) is located below the plane of the opening of the detection recess.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811620766.4A CN109827941B (en) | 2018-12-28 | 2018-12-28 | Convex high-flux high-repeatability substrate structure |
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| CN201811620766.4A CN109827941B (en) | 2018-12-28 | 2018-12-28 | Convex high-flux high-repeatability substrate structure |
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Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102169086B (en) * | 2010-12-31 | 2013-01-09 | 清华大学 | Molecular carrier for single molecule detection |
| CN104520694B (en) * | 2012-08-10 | 2018-05-15 | 浜松光子学株式会社 | Surface enhanced Raman scattering unit and its application method |
| CN104508465B (en) * | 2012-08-10 | 2018-12-21 | 浜松光子学株式会社 | Surface enhanced raman scattering unit |
| CN102998297A (en) * | 2012-12-11 | 2013-03-27 | 东南大学 | Porous microscale reaction plate for surface enhanced Raman scattering spectrum analysis |
| CN205103162U (en) * | 2015-10-15 | 2016-03-23 | 南京财经大学 | High flux detects surface reinforcing basement device of sulfydryl class compound |
| TW201725376A (en) * | 2016-01-14 | 2017-07-16 | 雲陽科技有限公司 | Rapid analysis of bacteria by using handheld surface enhanced raman scattering spectrometer does not only perform single or continuous detection for bacteria specimen but also perform statistical analysis for continuously analyzed group spectrum data |
| CN206192888U (en) * | 2016-11-30 | 2017-05-24 | 武汉大学 | A device for surface enhanced raman spectroscopy detects |
| CN207248750U (en) * | 2017-08-17 | 2018-04-17 | 安徽中科赛飞尔科技有限公司 | A kind of SERS substrates carry detection device |
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