CN109771850A - A kind of adaptive radiotherapy planning modification method - Google Patents
A kind of adaptive radiotherapy planning modification method Download PDFInfo
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Abstract
The invention discloses a kind of adaptive radiotherapy planning modification method, include the following steps: to obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；Image registration is carried out to target image and reference picture, generates 3 D deformation field；According to 3 D deformation field, generates blending image identical with reference picture coverage area and target is delineated；The two-dimentional deformation field of transmitted intensity in each beam direction is determined according to the 3 D deformation field in region of interest；The two-dimentional ray density distribution in corresponding beam direction is deformed according to two-dimentional deformation field, generates new two-dimentional ray density distribution；According to new two-dimentional ray density distribution, corresponding grating and tungsten door exercise data are generated.The present invention is based on 3-D image registration techniques, by the way that three-dimensional vector field is projected as bivector field, and are used for the deformation of intensity distribution, realize the adaptive correction to radiotherapy planning, greatly reduce doctor's workload.
Description
Technical field
The invention belongs to radiotherapy technology field more particularly to a kind of adaptive radiotherapy planning modification methods.
Background technique
One course for the treatment of of radiotherapy usually requires one month or the longer time, first according to the initial fixed of patient before radiotherapy starts
Bit image generates radiotherapy planning.But the location and shape of patient's tumour would generally change in entire Patients During Radiotherapy, this
The deviation for occurring radiological dose in Patients During Radiotherapy is resulted in, radiotherapeutic effect is not only influenced, more likely will affect the normal of patient
Organ-tissue leads to complication.
In order to solve this problem, it usually needs to carry out patient after radiotherapy starts a period of time in the prior art
Reorientation obtains the new image of patient by reorientation, and doctor re-starts according to new images delineates and formulate radiotherapy planning, but
It is that this process needs to consume the very big workload of doctor.
In the prior art and groundless new images and new delineate are modified reference radiotherapy planning to obtain new radiotherapy planning
Technical solution.Chinese patent CN108744313A discloses a kind of radiotherapy planning planing method, which comprises obtains swollen
Tumor target scan image and initial radiotherapy plan；By tumor target scan image, measured with a different shift on three-dimensional into
Line displacement obtains multiple migrated images of tumor target；According to tumor target scan image and initial radiotherapy plan, radiotherapy is established
Plan library；Radiotherapy planning library includes multiple radiotherapy plannings with tumor target scan image different location difference, radiotherapy planning packet
Include multiple radiotherapy planning sections associated with the period.The above method by being deviated the offset to cooperate organ to target area,
It is mainly used in real-time tumor motion tracking, but the above method can not handle the deformation of tumor target and peripheral organs, and
Adaptation cannot be carried out to deformation.
Therefore, how a kind of adaptive radiotherapy planning amendment that can handle tumour and organ displacement and deformation simultaneously is provided
Method is current those skilled in the art technical problem urgently to be resolved to realize the adaptation to radiotherapy planning.
Summary of the invention
In order to solve the above-mentioned technical problem.The present invention proposes a kind of adaptive radiotherapy planning modification method, is put using reference
Plan is treated, the modified radiotherapy planning after generating reorientation greatly reduces the workload of doctor, improves radiotherapy precision.Tool
Body technique scheme is as follows.
A kind of adaptive radiotherapy planning modification method, the modification method include the following steps:
Step S1: obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
Step S2: carrying out image registration to target image and reference picture, generates corresponding three-dimensional and deforms vector field；
Step S3: according to the 3 D deformation vector field, target image is generated as identical as reference picture coverage area
Blending image and description target area and the targets of organ contours delineate；
Step S4: it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each in radiotherapy planning
The two dimension deformation vector field of transmitted intensity in beam direction；
Step S5: according to the two dimension deformation vector field of transmitted intensity in each beam direction to described with reference in radiotherapy planning
Two-dimentional ray density distribution in corresponding beam direction is deformed, and two-dimentional transmitted intensity new in each beam direction point is generated
Cloth；
Step S6: according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten are generated
Door exercise data to get arrive new radiotherapy planning.
Preferably, the reference picture, with reference to the image once positioned before delineating, being respectively referred to reference to radiotherapy planning, delineate
And radiotherapy planning；Wherein,
Reference picture refers to for carrying out with reference to CT image, the MR image, PET image delineated and formulated with reference to radiotherapy planning
Or ultrasound image.
Preferably, the target image refer to newly obtain be able to reflect anatomical structure variation CT image, MR image,
PET image or ultrasound image.
Preferably, the image registration in the step S2 includes first latter two steps: the first step is to target image and ginseng
It examines image and carries out image rigid registration；Second step is to carry out anamorphose registration on the basis of the above.
Preferably, the region of interest includes target area and jeopardizes organ.
Preferably, the two dimension with reference to transmitted intensity in beam direction each in radiotherapy planning is determined in the step S4
It is that different weights is arranged in different region of interest during deforming vector field.
Preferably, it while generation blending image and target are delineated in the step S3, needs according to the 3 D deformation
Equal centers in reference radiotherapy planning are mapped on target image by vector field, to obtain the equal centers of new radiotherapy planning
Position.
By using the combination of one or more technical solution in the above summary of the invention, the present invention at least has below
The utility model has the advantages that, by the way that three-dimensional vector field is projected as bivector field, being used in combination the present invention is based on 3-D image registration technique
In the deformation of intensity distribution, the adaptive correction to radiotherapy planning is realized, greatly reduces doctor's workload.
It should be understood that above general description and following detailed description be only it is exemplary and explanatory, not
The application can be limited.
Detailed description of the invention
In order to illustrate more clearly of the embodiment of the present disclosure or technical solution in the prior art, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Disclosed some embodiments for those of ordinary skill in the art without creative efforts, can be with
Other attached drawings are obtained according to these figures.
Fig. 1 is the flow chart of the adaptive radiotherapy planning modification method of the present invention；
Fig. 2 is the schematic diagram that ray of the present invention passes through region of interest 3 D deformation vector field；
Fig. 3 is 3 D deformation vector perspective view on waiting central planes on ray of the present invention.
Specific embodiment
Below in conjunction with drawings and examples, the present invention is described in further detail.Aforementioned and other mesh of the invention
, features, aspects and advantages will be apparent, to enable those skilled in the art's refer to the instruction text real accordingly
It applies.
It is understood that specific embodiment described herein is used only for explaining the present invention, rather than to of the invention
It limits.It also should be noted that only the parts related to the present invention are shown for ease of description, in attached drawing and it is not all
Structure.It should be mentioned that some exemplary embodiments are described as making before exemplary embodiment is discussed in greater detail
The processing or method described for flow chart.Although operations (or step) are described as the processing of sequence by flow chart, its
In many operations can be implemented concurrently, concomitantly or simultaneously.In addition, the sequence of operations can be pacified again
Row.The processing can be terminated when its operations are completed, it is also possible to have the additional step being not included in attached drawing.Institute
Stating processing can cope in method, function, regulation, subroutine, subprogram etc..
It is only to be not intended to be limiting the application merely for for the purpose of describing particular embodiments in term used in this application.
It is also intended in the application and the "an" of singular used in the attached claims, " described " and "the" including majority
Form, unless the context clearly indicates other meaning.It is also understood that term "and/or" used herein refers to and wraps
It may be combined containing one or more associated any or all of project listed.
Embodiment 1
A kind of adaptive radiotherapy planning modification method, the modification method include the following steps.
(1) obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
The reference picture, with reference to the image once positioned before delineating, being respectively referred to reference to radiotherapy planning, delineate and radiotherapy meter
It draws.Wherein,
Reference picture refers to for carrying out with reference to CT image, the MR image, PET image delineated and formulated with reference to radiotherapy planning
Or ultrasound image.
Target image refers to that is newly obtained is able to reflect CT image, MR image, PET image or the ultrasound of anatomical structure variation
Image.
(2) image registration is carried out to target image and reference picture, generates corresponding three-dimensional and deforms vector field；
Wherein, image registration includes first latter two steps: the first step is rigid to target image and reference picture progress image
Body registration；Second step is to carry out anamorphose registration on the basis of the above.
(3) according to the 3 D deformation vector field, target image is generated as melt identical with reference picture coverage area
The target for closing image and description target area and organ contours is delineated；
(4) it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning
The two dimension deformation vector field of transmitted intensity on direction；Wherein,
The region of interest typically refers to target area, also may include and important jeopardizes organ.The region of interest of the setting
Which refer to that user can specify to generate in each beam direction using target area with intraorganic 3 D deformation vector field is jeopardized
The two dimension deformation vector field of transmitted intensity.
Usual user can specify only generates the deformation of transmitted intensity two dimension using the 3 D deformation vector field in the target area PTV
Vector field.If the amendment of plan influences organ important around tumour, such as spinal cord, user, which can specify, utilizes the target area PTV
With the 3 D deformation vector field in spinal cord, the two dimension deformation vector field of transmitted intensity in each beam direction is codetermined.True
It, can also be for not during the fixed two dimension deformation vector field with reference to transmitted intensity in beam direction each in radiotherapy planning
Region of interest together (such as: the target area PTV is more important, and weight is set as 3；Spinal cord weight is set as that different weights 1) is arranged.
(5) according to the two dimension deformation vector field of transmitted intensity in each beam direction to corresponding in the reference radiotherapy planning
Two-dimentional ray density distribution in beam direction is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
Two dimension deformation vector field is determined by 3 D deformation vector field briefly described in step (4)-(5) for Fig. 2-3；Again
The two-dimentional ray density distribution in beam direction is deformed by two dimension deformation vector field, generates two dimension new in beam direction
The process of ray density distribution.The region of interest that V indicates coordinate system's X, Y, Z axis is set in Fig. 2, arrow indicates in region of interest V
The 3 D deformation vector a of interior each pixel interested, deformation vector a may be expressed as:
A=x+y+z
R is a ray across region of interest V, and the deformation vector of the pixel passed through is respectively a1, a2, a3, is divided
It is not expressed as
A1=x1+y1+z1
A2=x2+y2+z2
A3=x3+y3+z3
It is to wait central planes referring to Fig. 3, S, waits central planes S parallel with plane where coordinate system X, Y-axis, wait central planes
Each point (that is, intersection point of ray R and equal central planes S) on S represents a ray, and the intensity of every ray is I, then exists
There are a two dimension ray density distribution I (x, y) on equal central planes.Then the corresponding 3 D deformation vector field of R ray is in waiting
Projection r in heart plane are as follows:
R=(x1+x2+x3)/3+ (y1+y2+y3)/3
As across the mean value of pixel 3 D deformation vector x durection component and y durection component.At this point, three-dimensional is become
Shape vector field is determined as the two dimension deformation vector field of transmitted intensity on equal central planes.
Again will etc. on central planes two dimension ray density distribution I (x, y) generated newly along this two dimension deformation vector field r deformation
Two-dimentional ray density distribution I ' (x, y).
(6) according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door fortune are generated
Data are moved to get new radiotherapy planning is arrived.
For the radiotherapy apparatus equipped with online device for image, the target image in the step (1) is by radiotherapy apparatus
The online device for image imaging that is equipped with, obtain automatically target image, target image etc. the radiotherapy planning of centers, that is, new
Equal centers.
For being not equipped with the radiotherapy apparatus of online device for image, the target image in the step (1) needs to pass through shadow
As device carries out reorientation imaging；While generation blending image and target are delineated in the step (3), need according to described three
Equal centers in reference radiotherapy planning are mapped on target image by dimension deformation vector field, to obtain new radiotherapy planning
Equal centers.
Embodiment 2
Based on the adaptive radiotherapy planning modification method of one of embodiment 1, the present embodiment further obtains a kind of adaptive
Radiotherapy planning update the system is answered, the system comprises
Data reception module, for obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
Radiotherapy planning correction module generates corresponding three-dimensional for carrying out image registration to target image and reference picture
Deform vector field；Further according to the 3 D deformation vector field, target image is generated as identical with reference picture coverage area
The target of blending image and description target area and organ contours, which is delineated, (is less than reference picture for the coverage area of target image
Situation, in the overlapping region of reference picture and target image, blending image is obtained by the deformable registration of reference picture to target image
It arrives；Region other than target image is obtained by the rigid registration of reference picture and target image)；Sense further according to setting is emerging
3 D deformation vector field in interesting area determines the two dimension deformation vector with reference to transmitted intensity in each beam direction in radiotherapy planning
?；Vector field is deformed to the two-dimentional transmitted intensity in corresponding beam direction further according to the two dimension of transmitted intensity in each beam direction
Distribution is deformed, and two-dimentional ray density distribution new in each beam direction is generated；According to new in each beam direction
Two-dimentional ray density distribution, generate corresponding grating and tungsten door exercise data to get to new radiotherapy planning.
For the embodiment of system, since it is substantially similar to the method in embodiment 1, so the comparison of description is simple
Single, something in common is not given and being repeated, and related place is referring to related description in embodiment 1.
Embodiment 3
On the basis of above-described embodiment 1-2, the present invention further discloses a kind of adaptive radiotherapy planning amendment dress
It sets, described device includes:
At least one processor；And
Memory is stored with executable instruction on the memory, and the executable instruction is by least one described processing
Device executes, and described device is caused to realize following method:
Obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
Image registration is carried out to target image and reference picture, corresponding three-dimensional is generated and deforms vector field；According to the three-dimensional
Vector field is deformed, target image is generated as blending image identical with reference picture coverage area and description target area and organ
The target of profile is delineated；
It is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam side in radiotherapy planning
The two dimension deformation vector field of upward transmitted intensity；According to the two dimension deformation vector field of transmitted intensity in each beam direction to corresponding
Two-dimentional ray density distribution in beam direction is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
According to two-dimentional ray density distribution new in each beam direction, generate corresponding grating and tungsten door exercise data to get
To new radiotherapy planning.
The invention also discloses a kind of computer-readable storage medias, including executable instruction, and described instruction is by least one
When a processor executes, following method is realized:
At least one processor；And
Memory is stored with executable instruction on the memory, and the executable instruction is by least one described processing
Device executes, and described device is caused to realize following method:
Obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
Image registration is carried out to target image and reference picture, corresponding three-dimensional is generated and deforms vector field；According to the three-dimensional
Vector field is deformed, target image is generated as blending image identical with reference picture coverage area and description target area and organ
The target of profile is delineated；
It is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam side in radiotherapy planning
The two dimension deformation vector field of upward transmitted intensity；According to the two dimension deformation vector field of transmitted intensity in each beam direction to corresponding
Two-dimentional ray density distribution in beam direction is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
According to two-dimentional ray density distribution new in each beam direction, generate corresponding grating and tungsten door exercise data to get
To new radiotherapy planning.
For the embodiment of device and storage medium, since it is substantially similar to the method in embodiment 1-2, institute
To be described relatively simple, something in common is not given and being repeated, and related place illustrates referring to the part of embodiment 1-2.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (8)
1. a kind of adaptive radiotherapy planning modification method, which is characterized in that the modification method includes the following steps:
Step S1: obtain reference picture, with reference to delineate, with reference to radiotherapy planning, target image；
Step S2: carrying out image registration to target image and reference picture, generates corresponding three-dimensional and deforms vector field；
Step S3: according to the 3 D deformation vector field, target image is generated as melt identical with reference picture coverage area
The target for closing image and description target area and organ contours is delineated；
Step S4: it is determined according to the 3 D deformation vector field in the region of interest of setting described with reference to each beam in radiotherapy planning
The two dimension deformation vector field of transmitted intensity on direction；
Step S5: according to the two dimension deformation vector field of transmitted intensity in each beam direction to described with reference to corresponding in radiotherapy planning
Two-dimentional ray density distribution in beam direction is deformed, and two-dimentional ray density distribution new in each beam direction is generated；
Step S6: according to two-dimentional ray density distribution new in each beam direction, corresponding grating and tungsten door fortune are generated
Data are moved to get new radiotherapy planning is arrived.
2. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that the reference picture,
With reference to the image once positioned before delineating, being respectively referred to reference to radiotherapy planning, delineate and radiotherapy planning；Wherein,
Reference picture refers to for carrying out with reference to delineating and formulates with reference to the CT image of radiotherapy planning, MR image, PET image or surpass
Acoustic image.
3. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that the target image is
Refer to that is newly obtained is able to reflect CT image, MR image, PET image or the ultrasound image of anatomical structure variation.
4. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that in the step S2
Image registration includes first latter two steps: the first step is to carry out image rigid registration to target image and reference picture；Second step
To carry out anamorphose registration on the basis of the above.
5. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that raw in the step S3
During at blending image, if the coverage area of target image is less than reference picture, in reference picture and target image
Overlapping region, blending image are obtained by the deformable registration of reference picture to target image；Region other than target image, by joining
The rigid registration for examining image and target image obtains.
6. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that the region of interest packet
It includes target area and jeopardizes organ.
7. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that in the step S4 really
It is different senses during the fixed two dimension deformation vector field with reference to transmitted intensity in beam direction each in radiotherapy planning
Different weights is arranged in region of interest.
8. a kind of adaptive radiotherapy planning modification method according to claim 1, which is characterized in that raw in the step S3
While being delineated at blending image and target, need the equal centers in reference radiotherapy planning according to the 3 D deformation vector field
Position is mapped on target image, to obtain the equal centers of new radiotherapy planning.
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