CN109612898B - Flowable release test circulation cavity for suspending agent - Google Patents
Flowable release test circulation cavity for suspending agent Download PDFInfo
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- CN109612898B CN109612898B CN201811338090.XA CN201811338090A CN109612898B CN 109612898 B CN109612898 B CN 109612898B CN 201811338090 A CN201811338090 A CN 201811338090A CN 109612898 B CN109612898 B CN 109612898B
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- port
- suspending agent
- bin
- water pipe
- circulation
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- 239000000375 suspending agent Substances 0.000 title claims abstract description 41
- 238000012360 testing method Methods 0.000 title claims abstract description 14
- 230000009969 flowable effect Effects 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 15
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 23
- 239000000725 suspension Substances 0.000 claims description 9
- 230000009286 beneficial effect Effects 0.000 abstract description 7
- 239000002609 medium Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000002612 dispersion medium Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/0806—Details, e.g. sample holders, mounting samples for testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
A suspending agent flow release test circulation cavity comprises a circulation cavity shell, a connecting tee joint and a water pipe, wherein an annular groove is formed in the circulation cavity shell and used for fixing artificial skin, and the circulation cavity shell is divided into a suspending agent sample bin and a physiological saline flow bin by the artificial skin; an opening is formed in one side of the suspending agent sample bin, an adjusting plug is arranged in the opening in a sliding mode, and suspending agent medicines are placed in the suspending agent sample bin; a medium filling port is arranged on the suspending agent sample bin; the top of the physiological saline circulation bin is provided with an outflow port, and the bottom of the physiological saline circulation bin is provided with an inflow port; the connecting tee comprises a bottom port, a top port and a side port, the top port is connected with the medium filling port through a water pipe, and the side port is connected with the inflow port through a water pipe. By using the tee joint, the water pressure at two sides of the artificial skin is consistent, which is beneficial to the release of the suspending agent drug.
Description
Technical Field
The invention belongs to the technical field of medical experimental equipment application, and particularly relates to a flow cavity for a suspension agent flow release test.
Background
Suspensions, also known as suspensions (suspensions), refer to non-homogeneous liquid formulations of poorly soluble solid drugs dispersed in a particulate state in a dispersion medium. The drug particles in the suspension are generally between 0.5-10 μm, small ones can be 0.1 μm, and large ones can be 50 μm or more. The suspension is a thermodynamically unstable coarse dispersion system, and most of the dispersion media used are water, and vegetable oil can also be used. The suspension has the advantages of 1, quick gastrointestinal absorption, 2, contribution to improving bioavailability and high dispersity. 3. Is suitable for children. 4. The insoluble drug can be prepared into a liquid preparation for clinical application; 5. the drug can be made into suspension for sustained release.
When the suspending agent is used for a flow release test, a circulation cavity is used for simulating a medication environment, artificial skin is vertically arranged in the circulation cavity, one side of the artificial skin is filled with normal saline, and the other side of the artificial skin is filled with suspending agent drugs; the bottom end of one side filled with the normal saline flows into the normal saline, and the top end of the side filled with the normal saline flows out of the normal saline, so that the device is used for the blood flowing process under the skin of a human body. The permeation effect of the suspending agent on human skin is detected by periodically extracting physiological saline.
The disadvantages of this approach are as follows: fill normal saline one side bottom and flow into normal saline, the top is flowed out normal saline, forms rivers and flows, can form water pressure to the artificial skin of suspending agent medicine one side, is unfavorable for the medicine release effect test.
Disclosure of Invention
In order to solve the existing problems, the invention discloses a flow-through cavity for testing the flow release of a suspending agent, which has the following specific technical scheme:
a suspending agent flow release test circulation cavity is characterized by comprising a circulation cavity shell, a connecting tee joint and a water pipe, wherein an annular groove is formed in the circulation cavity shell and used for fixing artificial skin, the artificial skin is vertically arranged in the shell, and the circulation cavity shell is divided into a suspending agent sample bin and a physiological saline circulation bin by the artificial skin; an opening is formed in one side of the suspending agent sample bin, an adjusting plug is arranged in the opening in a sliding mode, and suspending agent medicines are placed in the suspending agent sample bin; a medium filling port is arranged on the suspending agent sample bin;
the top of the physiological saline circulation bin is provided with an outflow port, and the bottom of the physiological saline circulation bin is provided with an inflow port;
the connecting tee joint comprises a bottom port, a top port and a side port, the top port is connected with the medium filling port through a water pipe, and the side port is connected with the inflow port through a water pipe; the bottom port flows into the normal saline, and the top port flows out of the normal saline and is connected with a medium filling port on the suspending agent sample bin through a water pipe; the side port flows out of the normal saline and is connected with the inflow port through a water pipe, and the normal saline flows in from the inflow port and flows out from the outflow port after passing through the normal saline flowing bin.
Furthermore, the adjusting plug is of a cylindrical structure, and the size of the adjusting plug is matched with that of the opening.
Further, an elastic sealing ring is arranged on the adjusting plug in the circumferential direction.
The invention has the beneficial effects that:
by using the tee joint, the water pressure at two sides of the artificial skin is consistent, which is beneficial to the release of the suspending agent drug.
The invention simulates the absorption structure of human body, is beneficial to the test of the release of suspending agent drugs and has good use effect.
Drawings
FIG. 1 is a schematic of the present invention.
List of reference numerals:
the device comprises a flow-through cavity shell 1, an annular groove 2, artificial skin 3, a suspending agent sample bin 4, a regulating plug 5, a medium filling port 6, a physiological saline flow-through bin 7, an outflow port 8, an inflow port 9, a connecting tee 10, a bottom port 11, a top port 12, a side port 13, a water pipe 14 and an opening 15.
Detailed Description
In order to make the technical scheme of the invention clearer and clearer, the invention is further described with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent replacement and conventional reasoning on the technical characteristics of the technical scheme of the invention falls into the protection scope of the invention. The fixed connection, the fixed arrangement and the fixed structure mentioned in the embodiment are all known technologies known to those skilled in the art, such as welding, screw connection, bolt-nut connection, riveting and the like.
A suspending agent flow release test circulation cavity is characterized by comprising a circulation cavity shell, a connecting tee joint and a water pipe, wherein an annular groove is formed in the circulation cavity shell and used for fixing artificial skin, the artificial skin is vertically arranged in the shell, and the circulation cavity shell is divided into a suspending agent sample bin and a physiological saline circulation bin by the artificial skin; an opening is formed in one side of the suspending agent sample bin, an adjusting plug is arranged in the opening in a sliding mode, and suspending agent medicines are placed in the suspending agent sample bin; a medium filling port is arranged on the suspending agent sample bin;
the top of the physiological saline circulation bin is provided with an outflow port, and the bottom of the physiological saline circulation bin is provided with an inflow port;
the connecting tee joint comprises a bottom port, a top port and a side port, the top port is connected with the medium filling port through a water pipe, and the side port is connected with the inflow port through a water pipe; the bottom port flows into the normal saline, and the top port flows out of the normal saline and is connected with a medium filling port on the suspending agent sample bin through a water pipe; the side port flows out of the normal saline and is connected with the inflow port through a water pipe, and the normal saline flows in from the inflow port and flows out from the outflow port after passing through the normal saline flowing bin.
Furthermore, the adjusting plug is of a cylindrical structure, and the size of the adjusting plug is matched with that of the opening.
Further, an elastic sealing ring is arranged on the adjusting plug in the circumferential direction.
The invention has the beneficial effects that:
by using the tee joint, the water pressure at two sides of the artificial skin is consistent, which is beneficial to the release of the suspending agent drug.
The invention simulates the absorption structure of human body, is beneficial to the test of the release of suspending agent drugs and has good use effect.
Claims (3)
1. A suspending agent flow release test circulation cavity is characterized by comprising a circulation cavity shell, a connecting tee joint and a water pipe, wherein an annular groove is formed in the circulation cavity shell and used for fixing artificial skin, the artificial skin is vertically arranged in the shell, and the circulation cavity shell is divided into a suspending agent sample bin and a physiological saline circulation bin by the artificial skin; an opening is formed in one side of the suspending agent sample bin, an adjusting plug is arranged in the opening in a sliding mode, and suspending agent medicines are placed in the suspending agent sample bin; a medium filling port is arranged on the suspending agent sample bin;
the top of the physiological saline circulation bin is provided with an outflow port, and the bottom of the physiological saline circulation bin is provided with an inflow port;
the connecting tee joint comprises a bottom port, a top port and a side port, the top port is connected with the medium filling port through a water pipe, and the side port is connected with the inflow port through a water pipe; the bottom port flows into the normal saline, and the top port flows out of the normal saline and is connected with a medium filling port on the suspending agent sample bin through a water pipe; the side port flows out of the normal saline and is connected with the inflow port through a water pipe, and the normal saline flows in from the inflow port and flows out from the outflow port after passing through the normal saline flowing bin.
2. A suspension flow release test flowthrough chamber as claimed in claim 1, wherein said actuator plug is of cylindrical configuration and is sized to fit said opening.
3. A suspension flow release test flowthrough chamber as claimed in claim 1, wherein said actuator plug is circumferentially provided with an elastomeric seal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811338090.XA CN109612898B (en) | 2018-11-12 | 2018-11-12 | Flowable release test circulation cavity for suspending agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811338090.XA CN109612898B (en) | 2018-11-12 | 2018-11-12 | Flowable release test circulation cavity for suspending agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109612898A CN109612898A (en) | 2019-04-12 |
| CN109612898B true CN109612898B (en) | 2021-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811338090.XA Active CN109612898B (en) | 2018-11-12 | 2018-11-12 | Flowable release test circulation cavity for suspending agent |
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| Country | Link |
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| CN (1) | CN109612898B (en) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1308229A (en) * | 2001-02-23 | 2001-08-15 | 国家药品监督管理局天津药物研究院 | Balance dialyzer |
| JP2007114172A (en) * | 2005-10-21 | 2007-05-10 | Kosumedei Seiyaku Kk | Apparatus for measuring diffusion of percutaneously absorptive drug |
| CN102671292A (en) * | 2011-03-16 | 2012-09-19 | 上海蓝怡科技有限公司 | Preparation method for noninvasive puerarin ion permeation medication system |
| CN103115852A (en) * | 2013-01-15 | 2013-05-22 | 禄根仪器(镇江)有限公司 | Transdermal diffusion apparatus |
| CN103499519A (en) * | 2013-10-10 | 2014-01-08 | 河南科技大学 | Composite physical field transdermal drug delivery experiment device |
| CN203798700U (en) * | 2014-05-02 | 2014-08-27 | 李焕婷 | Medicine percutaneous absorption experimental device |
| CN105651995A (en) * | 2016-02-19 | 2016-06-08 | 武汉大复生物科技有限公司 | Method for detecting EVs (extracellular vesicles) released by ECs (endothelial cells) and EPCs (endothelial progenitor cells) in blood |
| CN106568911A (en) * | 2016-10-26 | 2017-04-19 | 天津科技大学 | In vitro simulated skin model |
| CN206583758U (en) * | 2017-01-18 | 2017-10-24 | 中国科学院上海药物研究所 | Horizontal drug transdermal diffusion cell |
| CN108387697A (en) * | 2018-01-25 | 2018-08-10 | 湖南慧泽生物医药科技有限公司 | It is a kind of simulation suppository or transdermal patch body discharge and absorption process experimental provision |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8322193B2 (en) * | 2009-11-23 | 2012-12-04 | Logan Instruments Corp. | Transdermal diffusion cell testing arrangements and methods |
-
2018
- 2018-11-12 CN CN201811338090.XA patent/CN109612898B/en active Active
Patent Citations (10)
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|---|---|---|---|---|
| CN1308229A (en) * | 2001-02-23 | 2001-08-15 | 国家药品监督管理局天津药物研究院 | Balance dialyzer |
| JP2007114172A (en) * | 2005-10-21 | 2007-05-10 | Kosumedei Seiyaku Kk | Apparatus for measuring diffusion of percutaneously absorptive drug |
| CN102671292A (en) * | 2011-03-16 | 2012-09-19 | 上海蓝怡科技有限公司 | Preparation method for noninvasive puerarin ion permeation medication system |
| CN103115852A (en) * | 2013-01-15 | 2013-05-22 | 禄根仪器(镇江)有限公司 | Transdermal diffusion apparatus |
| CN103499519A (en) * | 2013-10-10 | 2014-01-08 | 河南科技大学 | Composite physical field transdermal drug delivery experiment device |
| CN203798700U (en) * | 2014-05-02 | 2014-08-27 | 李焕婷 | Medicine percutaneous absorption experimental device |
| CN105651995A (en) * | 2016-02-19 | 2016-06-08 | 武汉大复生物科技有限公司 | Method for detecting EVs (extracellular vesicles) released by ECs (endothelial cells) and EPCs (endothelial progenitor cells) in blood |
| CN106568911A (en) * | 2016-10-26 | 2017-04-19 | 天津科技大学 | In vitro simulated skin model |
| CN206583758U (en) * | 2017-01-18 | 2017-10-24 | 中国科学院上海药物研究所 | Horizontal drug transdermal diffusion cell |
| CN108387697A (en) * | 2018-01-25 | 2018-08-10 | 湖南慧泽生物医药科技有限公司 | It is a kind of simulation suppository or transdermal patch body discharge and absorption process experimental provision |
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| Publication number | Publication date |
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| CN109612898A (en) | 2019-04-12 |
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