CN109599159A - The weighing technique of insulin dose and its application apparatus when obtaining meal in insulin intensive treatment - Google Patents
The weighing technique of insulin dose and its application apparatus when obtaining meal in insulin intensive treatment Download PDFInfo
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 188
- 102000004877 Insulin Human genes 0.000 title claims abstract description 100
- 108090001061 Insulin Proteins 0.000 title claims abstract description 100
- 229940125396 insulin Drugs 0.000 title claims abstract description 100
- 235000012054 meals Nutrition 0.000 title claims abstract description 64
- 238000000034 method Methods 0.000 title claims abstract description 26
- 238000005303 weighing Methods 0.000 title claims abstract description 20
- 239000008280 blood Substances 0.000 claims abstract description 64
- 210000004369 blood Anatomy 0.000 claims abstract description 64
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 51
- 239000008103 glucose Substances 0.000 claims abstract description 51
- 238000012545 processing Methods 0.000 claims abstract description 28
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 22
- 238000002347 injection Methods 0.000 claims abstract description 12
- 239000007924 injection Substances 0.000 claims abstract description 12
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 8
- 235000014633 carbohydrates Nutrition 0.000 claims description 33
- 235000000346 sugar Nutrition 0.000 claims description 26
- 230000000291 postprandial effect Effects 0.000 claims description 22
- 235000021152 breakfast Nutrition 0.000 claims description 17
- 206010022489 Insulin Resistance Diseases 0.000 claims description 12
- -1 insulin carbohydrate Chemical class 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 9
- 235000005911 diet Nutrition 0.000 claims description 5
- 230000037213 diet Effects 0.000 claims description 5
- 150000008163 sugars Chemical class 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract description 6
- 238000012806 monitoring device Methods 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 20
- 210000000496 pancreas Anatomy 0.000 description 6
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical class [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
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- 238000001802 infusion Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
- 108010057186 Insulin Glargine Proteins 0.000 description 1
- COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940060975 lantus Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/60—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
Abstract
It include data processing module and the electronic scale and touching display screen that are electrically connected respectively with data processing module the present invention relates to the weighing technique of insulin dose and its application apparatus, the device when obtaining meal in a kind of insulin intensive treatment；Touching display screen is used to input information to data processing module and shows the information that data processing module exports；Electronic scale is used to weigh for food materials and sends data processing module for weighing data；Data processing module is used to calculate insulin dose required for this meal according to the information that electronic scale and touching display screen input.Design science of the present invention, it is easy to operate, it is easy to use, both the practical difficulty of carbohydrate calculating had been solved, patient is helped to arrange the data and variation tendency that blood glucose monitoring device offer is utilized again, have great importance in carrying out specification injection of insulin dependent diabetes education, the needs of practical application can be met well.
Description
Technical field
The invention belongs to treating diabetes technical fields, and in particular to pancreas islet when obtaining meal in a kind of insulin intensive treatment
The weighing technique of plain dosage and its application apparatus.
Background technique
Diabetic's quantity is increasing rapidly in worldwide, this growth and aging of population, economic development,
Lifestyle change is related.International Diabetes Federation (International Diabetes Federation, IDF) 2016
7th edition world's diabetes map denotation of publication has in worldwide 4.15 hundred million adults with diabetes, and it is expected that
The year two thousand forty, the maturity-onset diabetes patient in global range are up to 6.42 hundred million, i.e., 1 people in every 10 adults, just with sugar
Urine disease.Meanwhile maximum case growth rate will occur in area in economic development, have 1/3 diabetic to live in hair
It is national in exhibition.
With the acceleration of rapid economic development and process of industrialization, the acceleration of living-pattern preservation and aging process
The illness rate of China's diabetes is just being in zooming trend, becomes another serious danger after cardiovascular and cerebrovascular disease, tumour
The important Chronic Non-Communicable Diseases of evil people's health.China is the country that diabetic's number is most in the world, according to IDF
The estimation of 7 editions world's diabetes maps, China's diabetic's size of population are 1.096 hundred million people, about the 2 of second India times,
4 times of the third position U.S., and it is expected that this number is up to 1.507 hundred million in the year two thousand forty.Diabetes are not only brought to diseased individuals
The human body and spiritual damage and the shortening for leading to the service life, return family, country brings heavy financial burden, and China is every
Year reaches 51,000,000,000 U.S. dollars for the health care costs of diabetes, causes heavy burden to the national economic development.
For diabetes, presently the most effective and widely applied treatment method is still insulin complement treatment.With disease
The progress of journey finally substantially can be transitioned into insulin intensive treatment (Intensive Insulin Therapy), i.e. pancreas islet
Element pump treatment (Insulin Pump Therapy) or repeatedly subcutaneous injection of insulin (Multiple Dose Injection).
Research (Real World Study, RWS) from real world is shown in insulin intensive treatment, even if receiving specification
Injection treatment, the glycemic control of patient still can not be up to standard, main reason is that self-management in diabetes (Diabetic
Self-management) the missing of ability, i.e. patient can not be according to carbon hydrates in preprandial glucose level and institute's dietary intake
The dosage of insulin when meal is calculated in object amount.
Under normal conditions, the dosage of insulin is determined by two parts dynamic factor when meal, preprandial glucose and this meal
The content of middle carbohydrate.When meal on the one hand insulin corrects blood glucose level too high or too low before the meal, on the other hand neutralizes
The carbon water taken in when meal, to guarantee that level of postprandial blood sugar reaches control target.Common diabetes education mode in the world
It just include insulin dosage when how to calculate carbohydrate quantity and meal in (Diabetic Education Module)
Adjustment, but have no since diet between east and west is there are huge difference, and in the culinary art tradition in China the concept of tool metering, this
Part extremely lacks in China's diabetes community with the extremely close ability of self-management of insulin therapy.It previously studies aobvious
Show, in the patient for receiving insulin intensive treatment, 90% or more is not aware that is that carbohydrate calculates, and and does not know
Insulin dose when how road adjusts meal.The operation equipment auxiliary that one kind is intuitive, easy is needed in clinical practice work carries out pancreas
Island element dosage adjusts the propaganda and education of relevant self-management in diabetes knowledge.
Summary of the invention
For above-mentioned problems of the prior art, it can avoid above-mentioned skill occur the purpose of the present invention is to provide one kind
The weighing technique of insulin dose and its application apparatus when obtaining meal in the insulin intensive treatment of art defect.
In order to achieve the above-mentioned object of the invention, technical solution provided by the invention is as follows:
The application apparatus of insulin dose when obtaining meal in a kind of insulin intensive treatment, including data processing module and
The electronic scale and touching display screen being electrically connected respectively with data processing module；Touching display screen is used to input to data processing module
Information and the information of display data processing module output；Electronic scale is used to weigh for food materials and sends data for weighing data
Processing module；Data processing module is used to calculate pancreas required for this meal according to the information that electronic scale and touching display screen input
Island element dosage.
The weighing technique of insulin dose when obtaining meal in a kind of insulin intensive treatment, using above-mentioned application apparatus come
It realizes.
Further, the calculation formula of insulin dose when the meal that the weighing technique uses are as follows:
Insulin dose when meal=[(preprandial blood glucose values-target value)/insulin sensitivity coefficient+(carbohydrate in diet
Total amount/insulin carbohydrate ratio)] * regulation.
Further, insulin carbohydrate ratio is calculated using 450 rules or 500 rules, and user is most
The monitoring of junior three day blood glucose meter three before the meal, three postprandial blood sugars and sleep preceding blood glucose, obtain respective value, inputted by touching display screen
In data processing module；Application apparatus detect breakfast, lunch and dinner Chinese meal automatically before, postprandial blood sugar difference it is the smallest primary, according to this meal
Carbohydrate quantity divided by insulin dose when meal to get the insulin carbohydrate ratio of the breakfast, lunch and dinner to after correcting, and stores
In data processing module.
Further, the calculation formula of 450 rules is IC Ratio=450/ whole day insulin dose；The meter of 500 rules
Calculation formula is IC Ratio=500/ whole day insulin dose.
Further, insulin sensitivity coefficient is calculated using 1500 rules or 1800 rules, corrects breakfast, lunch and dinner insulin
After carbohydrate ratio, user be further continued for monitoring three days three before the meal, three postprandial blood sugars and sleep preceding blood glucose, obtain respective value
And it inputs in application apparatus, while inputting each pre-meal insulin injection dosage；Device automatically selects postprandial blood sugar in 8-
Between 12mmol/L and preprandial glucose differs maximum primary with postprandial blood sugar, and the absolute value of difference before the meal and between postprandial blood sugar/
[insulin dose-carbohydrate quantity/insulin carbohydrate ratio when meal], it can the insulin after being corrected is quick
Feel coefficient.
Further, 1500 rule calculation formula are ISF=1500/ (whole day insulin dose × 18)；1800 rule meters
Calculation formula is ISF=1800/ (whole day insulin dose × 18).
Further, the value of regulation is 90%, 100% or 110%.
The weighing technique of insulin dose and its application apparatus when obtaining meal in insulin intensive treatment provided by the invention,
Design science, it is easy to operate, it is easy to use, not only solved the practical difficulty of carbohydrate calculating, but also patient is helped to arrange benefit
The data and variation tendency provided with blood glucose monitoring device, have in carrying out specification injection of insulin dependent diabetes education
Important meaning can meet the needs of practical application well.
Detailed description of the invention
Fig. 1 is the dynamic glucose figure that embodiment 2 tries out patient before the insulin dose that method provided by the invention obtains
Spectrum；
Fig. 2 is the dynamic glucose figure that embodiment 2 tries out patient after the insulin dose that method provided by the invention obtains
Spectrum.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawing and specific implementation
The present invention will be further described for example.It should be appreciated that described herein, specific examples are only used to explain the present invention, and does not have to
It is of the invention in limiting.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work premise
Under every other embodiment obtained, shall fall within the protection scope of the present invention.
The application apparatus of insulin dose when obtaining meal in a kind of insulin intensive treatment, including electronic scale, a data
Processing module and touching display screen, the processor that data processing module uses can be arm processor, can for CC2540,
CC2530 etc.；Electronic scale and touching display screen are electrically connected with data processing module respectively；By touching display screen to data processing
Preprandial glucose numerical value is inputted in module and the food materials of this meal are placed on electronic scale by dynamic trend, user one by one, it is every to place one
Food materials code is inputted to touching display screen while kind food materials, data processing module is inputted according to electronic scale and touching display screen
Information calculates the dosage of insulin required for this meal.
Here data processing module is preferably the system module of the energy input Pinyin of a similar PDA because " food at
Point table " there are many inner content, it is desirable to and the state reached is one noun of input, such as apple, can jump out several options, than
Such as " apple (Fuji apple) ", " apple (state's light) ".
The weighing technique of insulin dose when obtaining meal in a kind of insulin intensive treatment, the insulin dose when meal of use
Calculation formula are as follows:
Insulin dose when meal=[(preprandial blood glucose values-target value)/insulin sensitivity coefficient+(carbohydrate in diet
Total amount/insulin carbohydrate ratio)] * regulation；
Wherein:
1. user measures preprandial blood glucose values with blood glucose meter, numerical value (mmol/L) is directly inputted by touching display screen.
2. target value is determined by clinician according to user's concrete condition, in international coverage at present to suggest postprandial blood sugar more
Between 8-12mmol/L, the target value of each user is provided by the comprehensive state of an illness state of clinician for control.
3. carbohydrate total amount is put into food materials one by one by user and weighs and input the corresponding phonetic of food materials in diet
Inquiry obtains (unit is g).
4. insulin carbohydrate ratio (Insulin Carbohydrate Ratio, IC Ratio), initial to use
When clinician " 450 rule " or " 500 rule " can be used calculate, the calculation formula of 450 rules is IC Ratio=
450/ whole day insulin dose.The calculation formula of 500 rules is 500/ whole day insulin dose of IC Ratio=.
User in the first three days for initially applying this application device, need to be monitored with blood glucose meter three before the meal, three postprandial blood sugars
And preceding blood glucose is slept, it obtains respective value and passes through in touching display screen input data processing module.First day, use A1-7It indicates；Second
It, uses B1-7It indicates；Third day, uses C1-7It indicates (unit is mmol/L).Each pre-meal insulin injection dosage is inputted simultaneously
I1-9.Device detect breakfast, lunch and dinner Chinese meal automatically before, postprandial blood sugar difference it is the smallest primary, according to the carbohydrate quantity of this meal, remove
Insulin dose and is stored in data processing module when eating to get to the IC Ratio of breakfast, lunch and dinner after correction.
5. insulin sensitivity coefficient (Insulin Sensitive Factor, ISF), clinician Ke Cai when initially using
It is calculated with " 1500 rule " or " 1800 rule ", it may be assumed that
1500 rule calculation formula are ISF=1500/ (whole day insulin dose × 18)；
1800 rule calculation formula are ISF=1800/ (whole day insulin dose × 18).After correcting breakfast, lunch and dinner IC Ratio,
User be further continued for monitoring three days three before the meal, three postprandial blood sugars and sleep preceding blood glucose (unit is mmol/L), obtain respective value
And in input unit, while inputting each pre-meal insulin injection dosage.Device automatically selects postprandial blood sugar in 8-12mmol/L
Between and preprandial glucose differ maximum primary with postprandial blood sugar, the absolute value of difference before the meal and between postprandial blood sugar/[pancreas islet when meal
Plain dosage-carbohydrate quantity/IC Ratio], it can the insulin sensitivity coefficient after being corrected.
6. the arrow of regulation, the reaction change of blood sugar immediate status being shown on touching display screen by blood glucose meter determines
(the numerical value upper right corner), on touching display screen, such as show →, then it is 100%；As display ↑, then be 110%；As display ↓, then for
90%.
It clearly requires, needs although having had in guide for the self-management etc. in insulin strengthening injection process
Patient learns the principle that carbohydrate calculates and insulin dose adjusts, but many studies have shown thats from real world refer to
There are huge wide gaps between the requirement and clinical practice in south.The research that inventor previously carries out in 1 patients with type Ⅰ DM group is aobvious
Show, in the type 1 diabetes patient that China receives insulin intensive treatment, glycemic control compliance rate is very low, and about 20%, and nine
At the above patient it is not apparent how adjusting insulin dose, and only it is applicable in fixed insulin dosage regimen (Rigid Insulin
Dosage).And the characteristics of China's eating habit, if only do not measured empirically according to weight, without fixed menu format, not divided meal
Disk etc. causes explanation carbohydrate calculating etc. in clinical position extremely difficult.Although the novel blood glucose prison such as the FGM occurred recently
Measurement equipment largely meets the demand of patient's Blood sugar self-measure, but patient still can not utilize a large amount of data information
Carry out clinical decision adjustment.The present invention had not only solved the practical difficulty of carbohydrate calculating, but also helped patient to arrange and be utilized
The data and variation tendency that blood glucose monitoring device provides have important in carrying out the education of specification injection of insulin dependent diabetes
Meaning.
Embodiment 1
Patient women, type 1 diabetes, 30 years old, 5 years old onset, insulin intensive treatment (excellent to secrete pleasure+Lantus), whole day pancreas
Island element dosage 35u, glycosylated hemoglobin 11.3% have already appeared diabetic retinopathy, merge 3 phase of chronic kidney disease.
1. estimation obtains IC ratio=500/35=14.3
ISF=1800/ (35x18)=2.85
2. being used this instrument 3 days according to above-mentioned application method, IC Ratio is corrected according to blood sugar monitoring result.
Blood glucose difference is minimum before and after 3rd day breakfast, and the carbohydrate of breakfast intake at that time is 48g, therefore obtains breakfast IC
Ratio is 1:6.
Blood glucose difference is minimum afterwards before lunch within 3rd day, and the carbohydrate of lunch intake at that time is 113g, therefore obtains lunch IC
Ratio is 1:12.5.
Blood glucose difference is minimum before and after dinner in 2nd day, and it is 50g that carbohydrate is taken in dinner at that time, therefore obtains dinner IC
Ratio is 1:10.
IC ratio: breakfast 1:6 after being corrected after 3 days；Lunch 1:12.5；Dinner 1:10, device is to above-mentioned data
Remembered.
It is with the biggest gap with the 4th day dinner blood glucose 3. after determining IC Ratio, continue monitoring blood glucose 3 days, carbon hydrate at that time
Object intake is 46g, and the IC Ratio for obtaining dinner before is 1:10.
Above-mentioned numerical value is substituted into formula: the absolute value of difference before the meal and between postprandial blood sugar/[insulin dose-carbon water when meal
Chemical combination object amount/IC Ratio], the insulin sensitivity coefficient after being corrected:
(14.2-12.9)/[5-46/10]=3.2
4. after being corrected after IC Ratio and insulin sensitivity coefficient, when each meal is eaten can by simply weigh food and
Survey preprandial glucose, insulin dose when machine is calculated automatically from meal according to aforementioned formula, the trial employment period monitor blood glucose situation and
Infusion of insulin situation is as follows:
Patient is in this way after insulin injection, and blood glucose fluctuation regional stability, different blood glucose levels are up to standard, meanwhile, it is real
Border injects total amount and is lower than traditional insulin intensive treatment injection volume, reduces the onset risk of complication.
Embodiment 2
Patient male, 64 years old, type 1 diabetes medical history 12 years, previously four subcutaneous injection of insulin controlled blood glucose, and be saccharified blood
Lactoferrin 7.5% frequently occurs hypoglycemia, whole day insulin dose 46u.
1. estimation obtains IC ratio=500/46=10.9
ISF=1800/ (46x18)=2.2
2. being used this instrument 3 days according to above-mentioned application method, IC Ratio is corrected according to blood sugar monitoring result.
Blood glucose difference is minimum before and after 2nd day breakfast, and the carbohydrate of breakfast intake at that time is 50g, therefore obtains breakfast IC
Ratio is 1:4.
Blood glucose difference is minimum afterwards before lunch within 3rd day, and the carbohydrate of lunch intake at that time is 85g, therefore obtains lunch IC
Ratio is 1:8.5.
Blood glucose difference is minimum before and after dinner in 2nd day, and it is 80g that carbohydrate is taken in dinner at that time, therefore obtains dinner IC
Ratio is 1:8.
IC ratio: breakfast 1:4 after being corrected after 3 days；Lunch 1:8.5；Dinner 1:8, device to above-mentioned data into
Row memory.
It is with the biggest gap with the 6th day breakfast blood glucose 3. after determining IC Ratio, continue monitoring blood glucose 3 days, carbon hydrate at that time
Object intake is 40g, and the IC Ratio for obtaining dinner before is 1:4.
Above-mentioned numerical value is substituted into formula: the absolute value of difference before the meal and between postprandial blood sugar/[insulin dose-carbon water when meal
Chemical combination object amount/IC Ratio], the insulin sensitivity coefficient after being corrected:
(11.0-6.8)/[12-40/4]=2.1
4. after being corrected after IC Ratio and insulin sensitivity coefficient, when each Can Can section by simply weigh food and
Survey preprandial glucose, insulin dose when machine is calculated automatically from meal according to aforementioned formula, the trial employment period monitor blood glucose situation and
Infusion of insulin situation is as follows:
5. Patients Before And After dynamic glucose map (ambulatory glucose profile, AGP) such as Fig. 1 and figure on probation
It is larger using preceding patient blood glucose fluctuation shown in 2, it is reduced using rear glucose fluctuation and hypoglycemia is reduced, blood glucose is in target
Time in range extends.
Embodiments of the present invention above described embodiment only expresses, the description thereof is more specific and detailed, but can not
Therefore limitations on the scope of the patent of the present invention are interpreted as.It should be pointed out that for those of ordinary skill in the art,
Without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (8)
1. the application apparatus of insulin dose when obtaining meal in a kind of insulin intensive treatment, which is characterized in that at data
Reason module and the electronic scale and touching display screen being electrically connected respectively with data processing module；Touching display screen is used for at data
It manages module input information and shows the information of data processing module output；Electronic scale is used to weigh for food materials and by weighing data
It is sent to data processing module；Data processing module is used to calculate this meal according to the information that electronic scale and touching display screen input
Required insulin dose.
2. the weighing technique of insulin dose when obtaining meal in a kind of insulin intensive treatment, which is characterized in that wanted using right
Application apparatus described in asking 1 is realized.
3. weighing technique according to claim 1 to 2, which is characterized in that insulin agent when the meal that the weighing technique uses
The calculation formula of amount are as follows:
Insulin dose when meal=[(preprandial blood glucose values-target value)/insulin sensitivity coefficient+(carbohydrate is total in diet
Amount/insulin carbohydrate ratio)] * regulation.
4. weighing technique according to claim 1 to 3, which is characterized in that insulin carbohydrate ratio uses 450 methods
Then or 500 rules are calculated, user the monitoring of most junior three day blood glucose meter three before the meal, three postprandial blood sugars and blood glucose before sleeping,
Respective value is obtained, by touching display screen input data processing module；Application apparatus detect breakfast, lunch and dinner Chinese meal automatically before, it is postprandial
Blood glucose difference is the smallest primary, according to the carbohydrate quantity of this meal, divided by insulin dose when meal to get to after correcting three
The insulin carbohydrate ratio of meal, and be stored in data processing module.
5. weighing technique according to claim 1 to 3, which is characterized in that the calculation formula of 450 rules is IC Ratio=
450/ whole day insulin dose；The calculation formula of 500 rules is IC Ratio=500/ whole day insulin dose.
6. weighing technique according to claim 1 to 3, which is characterized in that insulin sensitivity coefficient using 1500 rules or
1800 rules are calculated, correct breakfast, lunch and dinner insulin carbohydrate ratio after, user be further continued for monitoring three days three before the meal, three
Postprandial blood sugar and preceding blood glucose is slept, obtains respective value and input in application apparatus, while inputting each pre-meal insulin injection
Amount；Device automatically selects postprandial blood sugar between 8-12mmol/L and preprandial glucose differs maximum primary with postprandial blood sugar, meal
The absolute value of difference between preceding and postprandial blood sugar/[insulin dose-carbohydrate quantity/insulin carbohydrate ratio when meal
Value], it can the insulin sensitivity coefficient after being corrected.
7. weighing technique according to claim 1 to 3, which is characterized in that 1500 rule calculation formula are ISF=1500/
(whole day insulin dose × 18)；1800 rule calculation formula are ISF=1800/ (whole day insulin dose × 18).
8. weighing technique according to claim 1 to 3, which is characterized in that the value of regulation be 90%, 100% or
110%.
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| US20100262434A1 (en) * | 2007-12-13 | 2010-10-14 | Shaya Steven A | Method and apparatus to calculate diabetic sensitivity factors affecting blood glucose |
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| WO2018042147A1 (en) * | 2016-08-30 | 2018-03-08 | Imperial Innovations Limited | Automatic closed-loop glucose control with an adaptive meal bolus calculator |
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| US6691043B2 (en) * | 2001-08-28 | 2004-02-10 | Maxi-Med, Llc | Bolus calculator |
| US20050192494A1 (en) * | 2004-03-01 | 2005-09-01 | Barry H. Ginsberg | System for determining insulin dose using carbohydrate to insulin ratio and insulin sensitivity factor |
| US20050272640A1 (en) * | 2004-05-13 | 2005-12-08 | Doyle Francis J Iii | Method and apparatus for glucose control and insulin dosing for diabetics |
| CN101772769A (en) * | 2007-08-02 | 2010-07-07 | 诺沃-诺迪斯克有限公司 | Estimating a nutritonal parameter for assistting insulin administration |
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