CN109569749A - The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system - Google Patents
The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system Download PDFInfo
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- CN109569749A CN109569749A CN201811364682.9A CN201811364682A CN109569749A CN 109569749 A CN109569749 A CN 109569749A CN 201811364682 A CN201811364682 A CN 201811364682A CN 109569749 A CN109569749 A CN 109569749A
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- sliceable
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
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Abstract
The invention discloses a kind of sliceable digital microcurrent-controlled driving circuits, including main control module, boosting output module, communication interface modules；The output end of the main control module and the output end of the boosting output module, communication interface modules are all connected with；The input terminal of the main control module and the output end of communication interface modules connect.Also disclose a kind of portable sliceable digital microcurrent-controlled device, including sliceable digital microcurrent-controlled driving circuit and operation array module.A kind of portable sliceable microfluidic system, including multiple portable sliceable digital microcurrent-controlled devices are also disclosed, is connected between device by communication interface modules.A kind of portable sliceable digital microcurrent-controlled circuit of the present invention, device, system, the increase of operable array electrode platform quantity is realized by communication interface modules, so that digital microcurrent-controlled platform realizes manipulation drop on a large scale, and digital microcurrent-controlled platform is freely assembled and minimizes.
Description
Technical field
The present invention relates to microfluidic art, more particularly to a kind of portable sliceable digital microcurrent-controlled driving circuit,
Apparatus and system.
Background technique
Digital microcurrent-controlled platform: a kind of microfluidic control platform, in platform, liquid of the liquid as independent unit-sized
Drop is handled, these drops can be distributed from source, merged, divide or transported between demand point.Based on electrowetting
Digital microcurrent-controlled device can be realized by using surface electrode array, to control the shape of drop by electrowetting effect
The position and.
With the development of technology, digital microcurrent-controlled platform shows huge hair in chemistry, biology, medicine and other field
Potentiality and application prospect are opened up, such as in reagent detection, care diagnostic field, digital microcurrent-controlled platform all shows excellent
Performance.The care diagnostic platform minimized in recent years shows the development symptom of a trend gradually, how expanded matrix quantity and to reduce volume
More and more attention has been paid to.Unlike conventional digital microfluidic platform, the care diagnostic platform volume of miniaturization is more small and exquisite,
And detection function lower to the consumption of test material more even has more for specific aim for user according to self-demand
The array of DIY.It is digital microcurrent-controlled as array Platform freedom degree increases, volume is more small and exquisite, lower to the consumption of test material
Platform will become one of the emerging technology of great potential.
However, digital microcurrent-controlled due to its limitation, it is difficult to enlargement and progress mass production remain in experiment,
Platform can control the enlargement of quantity and capacity issue apparent.
Summary of the invention
The present invention is directed to solve at least some of the technical problems in related technologies.For this purpose, of the invention
One purpose is to provide a kind of sliceable digital microcurrent-controlled driving circuit, solve existing micro-fluidic driving circuit cannot connect it is more
The technical issues of a microfluidic platform.
For this purpose, solving number a second object of the present invention is to provide a kind of portable sliceable digital microcurrent-controlled device
The technical issues of splicing cannot be freely combined in word micro fluidic device.
For this purpose, being solved existing third object of the present invention is to provide a kind of portable sliceable digital microfluidic system
The technical problem for having digital microcurrent-controlled platform device bulky.
The technical scheme adopted by the invention is that:
In a first aspect, the present invention provides a kind of sliceable digital microcurrent-controlled driving circuit, including main control module, boosting output
Module, communication interface modules.The output end of main control module and the output end of boosting output module, communication interface modules are all connected with,
The input terminal of main control module and the output end of communication interface modules connect.
Further, communication interface modules is serial port module.
Further, boosting output module is using chip SSD1629QN10, for multidiameter delay output of boosting.
Further, main control module is using chip STM32F103CBT6, for handling control signal.
Second aspect, the present invention provide a kind of portable sliceable digital microcurrent-controlled device, including portable sliceable number
The micro-fluidic driving circuit of word and operation array module, portable sliceable digital microcurrent-controlled driving circuit pass through boosting output module
It is connect with operation array module.
Further, portable sliceable digital microcurrent-controlled device is that ito glass micro fluidic device or PCB electrode are micro-fluidic
Device, paper micro fluidic device.
Further, the interface that operation array module uses is row's needle or FPC connector.
Further, operation array module is Open architecture or closed structure.
Further, operation array module includes electrode coating material, and the electrode coating material is to have hydrophobicity
The material of demand, the electrode coating material include AF Teflon, Cytop, PDMS, Parafilm M.
Further, operation array module includes electrode, the shape of the electrode be traditional rectangle or half moon or
Annular saw tooth form.
Further, digital microcurrent-controlled device further includes wireless communication module, and the wireless communication module includes WIFI mould
Block and/or Zigbee module.
The third aspect, the present invention provide a kind of portable sliceable microfluidic system, including multiple portable sliceable numbers
Word micro fluidic device passes through communication interface modules between multiple portable sliceable digital microcurrent-controlled devices and connects.
The beneficial effects of the present invention are:
A kind of portable sliceable digital microcurrent-controlled driving circuit of the present invention, apparatus and system, pass through communication interface modules
The increase of operable array electrode platform quantity is realized, so that digital microcurrent-controlled platform realizes manipulation liquid on a large scale
Drop, and digital microcurrent-controlled platform is freely assembled and minimizes.
It the composite can be widely applied to microfluidic art.
Detailed description of the invention
Fig. 1 a is a kind of functional-block diagram of sliceable digital microcurrent-controlled circuit of the invention；
Fig. 1 b is a kind of block diagram of portable sliceable digital microcurrent-controlled device of the invention；
Fig. 2 is a kind of signal flow figure of portable sliceable digital microcurrent-controlled device of the invention；
Fig. 3 is liquid drop movement process schematic in the digital microcurrent-controlled device of the present invention；
Fig. 4 is splicing apparatus signal flow schematic diagram of the present invention；
The signal flow figure of Fig. 5 each intermodule when being two micro-fluidic array platform splicings of the present invention；
The signal flow figure of Fig. 6 each intermodule when being multiple micro-fluidic array platforms splicing of the invention.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase
Mutually combination.
Embodiment one
With reference to Fig. 1 a, a kind of functional-block diagram of sliceable digital microcurrent-controlled circuit.Sliceable digital microcurrent-controlled circuit packet
Main control module 1 is included, boost output module 2, communication interface modules 3.The output end of main control module 1 with boosting output module 2, communicate
The output end of interface module 3 is all connected with, and the input terminal of main control module 1 is connect with the output end of communication interface modules 3.
In the present embodiment, main control module 1, as central processing unit, is controlled using by STM32F103CBT6 for handling
Signal processed.
In the present embodiment, boosting output module 2, as boosting multidiameter delay output, rises using by SSD1629QN10
Pressing output module 2 further includes voltage output interface module.
In the present embodiment, communication interface modules 3 is serial port module.
With reference to Fig. 1 b, a kind of block diagram of portable sliceable digital microcurrent-controlled device.Portable sliceable number
Micro fluidic device includes sliceable digital microcurrent-controlled circuit and operation array module 4 in Fig. 1 a.Wherein, sliceable digital miniflow
Control driving circuit is connect by boosting output module 2 with operation array module 4.
With reference to Fig. 2, portable sliceable digital microcurrent-controlled device working principle are as follows: power supply to main control module 1 (including
STM32F103CBT6 chip) and boosting output module 2 (including SSD1629QN10 chip) be powered, by
The voltage-stabilizing system of ME6208A33M3G composition, which is realized, switchs to 3.3V for 5V；Main control module 1 (including STM32F103CBT6 chip) root
According to program to boosting output module 2 (including SSD1629QN10 chip) send control instruction, control boosting output module 2 (including
SSD1629QN10 chip) it boosts and exports as desired；Each SSD1629QN10 chip has 32 road voltage in parallel delivery outlets, can
Output voltage is up to 40V, exports one or multiple parallel electricity that will not be interfered with each other according to the instruction for receiving STM32
Pressure, and can occur the change of voltage change, the quantity of delivery outlet and position according to program within the unit time, export to connecing
Mouth connector.SSD1629QN10 chip is connected to voltage output interface module and carries out voltage output, and the voltage output connected connects
Mouth mold block can be any connector (row needle or FPC connector etc.), and connector concrete form, encapsulation are according to different platforms
Depending on demand；It operates in array module 4, the coating on electrode can have hydrophobic dielectric substance layer or film to be any, depending on tool
Depending on body situation, meet all applicable of dielectric electro-wetting principle；The operation array module 4 being connected can be the number of any kind
Microfluidic droplet operating platform (such as ito glass, PCB electrode and paper are micro-fluidic), each electrode are needed with every route
It is independent corresponding, the voltage output that SSD1629QN10 chip is exported to corresponding electrode.STM32F103CBT6 chip has
Three groups of communication serial ports, any number of driving device can be connected with each other, and the serial ports having all can realize letter for communication serial port
Breath interaction；Enter wait state (interruption) after STM32F103CBT6 chip has executed present procedure and refers to serial ports transmission
It enables；Instruction is transferred to another identical driving device of connection by serial ports, realizes information exchange with it, when driving device receives
It, can be according to requiring to send feedback signal when the instruction sent to other driving devices or computer, or will instruct down
Continue to transmit, to increase output port number to realize expansion control range.
The information of communication serial port transmission includes control information and feedback information, the communication information may include in each unit time
Inside as desired change array Platform on driving electrodes number, change driving electrodes position, adjustment electrode drive sequence, electricity
Pole activation point sequence changes, wakes up and drives on all driving device plates such as next device development board and indicator light flashing
The function command information of had module；The information of communication serial port transmission can be a simple trigger signal, when target is driven
When dynamic mount board receives signal, driven according to the corresponding informance Trigger Function set, or programmed electrode on demand
The instructions such as dynamic position, variation sequence are write another rise and are sent.
As shown in figure 3, liquid drop movement process schematic in digital microcurrent-controlled driving device.Drop contacts two neighboring simultaneously
When electrode, applies voltage to one of electrode and (reach as high as 40V, minimum is not 0, and Different electrodes size or material drive liquid
Voltage difference needed for dripping is different, illustrates by taking 40V as an example) another electrode application 0V, drop can be mobile toward high voltage direction, in Fig. 3
Driving liquid drop movement process in Open architecture and closed structure is listed respectively, and wherein electrode is by taking square as an example.
As shown in figure 4, splicing apparatus signal flow schematic diagram.The driving device plate of number 1-5 is connected, on array Platform
Electrode is divided into five regions A-E and respectively corresponds number 1-5.9. the drop on a-quadrant is carried out when No. 1 driving plate has executed instruction
Command information is sent after operation to next piece of driving plate and itself enters standby mode, and Yu Tuzhong is 1.；When No. 2 driving plates receive
When to signal, information is sent to next piece of driving plate after executing command adapted thereto 10. to region B and itself enters standby mode, in
In figure 3.；Feedback signal can also be sent to No. 1 driving plate, 2. in figure；One piece of driving plate can send transmitting information as 3. and
2. 2. 3. feedback information, but needs extremely short time interval, cannot be simultaneously；Every piece of driving plate receives information, executes life
It can according to need after order and carry the information to next driving plate or the upper one piece of driving plate of feedback information time.
General-purpose chip STM32 is utilized in the present embodiment and boost chip SSD1629, STM32 chip functions are powerful, has reality
The strength of existing multiple functions；SSD1629 chip boosting highest can rise to 40V, comply fully with the item of digital microcurrent-controlled driving drop
Part；And SSD1629 has 32 delivery outlets, and quantity is more, it can be achieved that multiple parallel delivery outlet exports, to realize that widespread adoption is beaten
Lower basis；STM32 has plural groups communication serial port, can be used between driving device or computer hands over the communication between device
Mutually, to realize the splicing of driving device plank, expand control range, and there is no restriction for the plank quantity spliced, thus real
Existing digital microcurrent-controlled enlarged drop control；And need enlargement when splice, other when can dismantle and be carried, side
It is portable, solve the problems, such as the heavy of large-scale digital microcurrent-controlled platform device；Applicable array Platform is wide, practical.
Embodiment two
With reference to serial Fig. 5, the signal flow figure of two micro-fluidic array platforms each intermodule when splicing.Two device drivings
Plate is connected, 3. driving drop is executed instruction around the mobile circle of electrod-array, No. 1 driving plate, and drop is moved to area by region A
Domain edge, and enter standby mode after sending information to No. 2 driving plates, such as 1.；When No. 2 driving plates receive instruction, by liquid
Drop is moved to from the position that Fig. 5 a is shown from A and B area edge；And drop is moved at the position that Fig. 5 b is shown；Similarly 2
4., 2. number mount board, which executes instruction, is moved to the position Fig. 5 c and Fig. 5 d.
Embodiment three
With reference to serial Fig. 6, the signal flow figure of multiple micro-fluidic array platforms each intermodule when splicing.The driving of muti-piece device
Plate is connected, and driving one is located at the drop of region A, 9. No. 1 driving plate, which executes instruction, drop and will send to a-quadrant and B area side
After boundary (such as Fig. 6 b), command information is sent to next piece of driving plate and 1. enters standby mode afterwards.No. 2 driving plates receive signal
It executes instruction later 10., drop is transported to B area and the zone boundary C (such as Fig. 6 c), send instruction letter to next piece of driving plate
3. breath enters standby mode afterwards；By this kind of method, the liquid of any amount, any position can be arbitrarily driven in the region A-E
Drop, which is moved to designated position and merges, divides or transport etc., to be acted；It is proprietary that each device driving plate has program to formulate
Device number, can be added in the identification burst of command information, when the non-targeted device of the number of identification, will instruct toward next
Transmitting；If No. 2 mount boards receive instruction, and the number identified is not the present apparatus after device 1 sends out command information
When, it will instruct and transmitted toward next mount board, itself is again introduced into standby mode；Each device driving plate all can serve as to issue
The starting point of instruction, the intermediate transit point of transmitting instruction or reception and exectorial terminal.
It is to be illustrated to preferable implementation of the invention, but the invention is not limited to the implementation above
Example, those skilled in the art can also make various equivalent variations on the premise of without prejudice to spirit of the invention or replace
It changes, these equivalent deformations or replacement are all included in the scope defined by the claims of the present application.
Claims (13)
1. a kind of sliceable digital microcurrent-controlled driving circuit, which is characterized in that including main control module, boosting output module and communication
Interface module；The output end of the main control module and the output end of the boosting output module, the communication interface modules connect
It connects；The input terminal of the main control module is connect with the output end of the communication interface modules.
2. sliceable digital microcurrent-controlled driving circuit according to claim 1, which is characterized in that the communication interface modules
For serial port module.
3. sliceable digital microcurrent-controlled driving circuit according to claim 1, which is characterized in that the boosting output module
Using chip SSD1629QN10, for multidiameter delay output of boosting.
4. sliceable digital microcurrent-controlled driving circuit according to claim 3, which is characterized in that the boosting output module
It further include voltage output interface module, the voltage output interface module is row's needle connector or FPC connector.
5. sliceable digital microcurrent-controlled driving circuit according to claim 1, which is characterized in that the main control module uses
Be chip STM32F103CBT6, for handle control signal.
6. a kind of portable sliceable digital microcurrent-controlled device, which is characterized in that including as described in any one of claim 1 to 5
Circuit and operation array module, the circuit by the boosting output module with operate array module connect.
7. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that described portable to spell
Connecing digital microcurrent-controlled device is ito glass micro fluidic device or PCB electrode micro fluidic device, paper micro fluidic device.
8. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that the operation array mould
The interface that block uses is row's needle or FPC connector.
9. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that the operation array mould
Block is Open architecture or closed structure.
10. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that the operation array
Module includes electrode coating material, and the electrode coating material is the material for having hydrophobicity demand, the electrode coating material
Material includes AF Teflon, Cytop, PDMS and Parafilm M.
11. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that the operation array
Module includes electrode, and the shape of the electrode is traditional rectangle or half moon or annular saw tooth form.
12. portable sliceable digital microcurrent-controlled device according to claim 6, which is characterized in that the number miniflow
Controlling device further includes wireless communication module, and the wireless communication module includes WIFI module and/or Zigbee module.
13. a kind of portable sliceable microfluidic system, which is characterized in that including multiple such as any one of claim 6 to 12 institute
The portable sliceable digital microcurrent-controlled device stated, by as weighed between the multiple portable sliceable digital microcurrent-controlled device
Benefit require 1 described in communication interface modules connection.
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|---|---|---|---|
| CN201811364682.9A CN109569749A (en) | 2018-11-16 | 2018-11-16 | The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system |
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| CN201811364682.9A CN109569749A (en) | 2018-11-16 | 2018-11-16 | The portable sliceable digital microcurrent-controlled driving circuit of one kind, apparatus and system |
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| CN110433880A (en) * | 2019-08-26 | 2019-11-12 | 成都凡迪医学检验所有限公司 | Micro-fluidic driving method and detection system |
| CN111229343A (en) * | 2020-01-19 | 2020-06-05 | 电子科技大学中山学院 | Splicing system and method of digital microfluidic platform |
| CN111760599A (en) * | 2020-06-08 | 2020-10-13 | 广州大学 | Modular spliced microfluid transportation device |
| CN112642502A (en) * | 2020-12-19 | 2021-04-13 | 电子科技大学中山学院 | Manufacturing and calculating method of digital micro-fluidic chip system |
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