CN109568676A - A kind of antibacterial super slippery medical retention conduit material - Google Patents
A kind of antibacterial super slippery medical retention conduit material Download PDFInfo
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- CN109568676A CN109568676A CN201811643832.XA CN201811643832A CN109568676A CN 109568676 A CN109568676 A CN 109568676A CN 201811643832 A CN201811643832 A CN 201811643832A CN 109568676 A CN109568676 A CN 109568676A
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- thiazolidine
- medical retention
- antibacterial super
- dicarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/043—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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Abstract
The invention discloses a kind of antibacterial super slippery medical retention conduit materials, by being made following preparation method: (one) polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide, (2) preparation of condensation polymer, (3) condensation polymer ionizes, the molding of (four) conduit material.The invention also discloses utilize medical retention conduit made of the antibacterial super slippery medical retention conduit material.Antibacterial super slippery medical retention conduit disclosed by the invention has sustained anti-microbial fungistatic effect with material, surface hydrophilic lubricity, flexibility, biocompatibility and the excellent advantage of comfort, the medical retention intubation catheter made of this material is easy, therapeutic effect is effectively increased, the pain of patient is alleviated.
Description
Technical field
The present invention relates to the field of medical instrument technology more particularly to a kind of antibacterial super slippery medical retention conduit materials.
Background technique
With the development of medical technology, medical retention conduit has been used not only for the rescue and treatment of urgent patient, and
Be widely used in medical practice, as venous transfusion, drug therapy, total intravenous nutrition, haemodynamics detection etc., especially
Be the first haemodialysis of uremic patient, poisoning salvage guide, acute renal failure and internal arteriovenous fistula prematurity person's first choice vascular routes.
As a kind of safe and effective diagnosing and treating tool, inlying catheter can indwelling in the blood vessels, to reduce puncture time, subtract
Hypopathia people pain reduces workload of the nurse, and application is increasingly extensive.
According to operation or nursing needs, generally require some medical retention conduits of indwelling in the preoperative (such as catheter, in
Cardiac vein conduit etc.) or some medical retention conduits (such as drainage tube) of postoperative indwelling, these medical retention conduits are according to disease
The time for not grade that the different syndromes of people need indwelling in vivo 1-30 days, easily cause during the indwelling of medical retention conduit
The infection of medical retention conduit periphery cavity or the surface of a wound increases operation risk and mortality, therefore, in order to reduce operation
Risk and curative effect, medical retention conduit material must have good anti-microbial property, bio-compatible performance.
Medical retention conduit mostly uses medical macromolecular materials to be made greatly at present, such as silicon rubber, polyurethane, polyvinyl chloride
Deng these existing medical retention conduit materials more or less have mechanical mechanics property, chemical stability needs further
Improve, due to material with tissue compatibility is bad leads to urinary tract infections and allergy, surface particles more slightly lose lubricity, very
It is easy to induce the growth of bacterial biof iotalm, patient is easily made to generate the feeling of pain as calcination during insertion, or even is viscous because damaging
Film and the defect for causing inflammation bring inconvenience to medical treatment, nursing, also cause unnecessary pain to patient, while also increasing
Add the hidden danger that medical tangle occurs, or even threatens the life and health safety of patient.
102247647 A of Chinese invention patent CN discloses disposable bacteriostatic ultra-smooth medical indwelling catheter, described to lead
Pipe includes the tube wall being made of medical macromolecular materials, special special feature in: the tube wall outer surface and or inner surface on
It is provided with for reducing the superslide dielectric layer of frictional force between conduit and tissue, is provided between the tube wall and superslide dielectric layer
Resist antibacterial dielectric layer.This material to a certain extent can reinforcing material antibiotic property and superslide, but this medical retention
Conduit MULTILAYER COMPOSITE bonds bad, easy delamination in use, especially under fluid environment, chemical stabilization between each layer
Property it is bad, resist antibacterial dielectric layer between tube wall and superslide dielectric layer, it cannot be guaranteed that the antibiotic property of entire conduit.
Therefore, develop it is a kind of there is sustained anti-microbial fungistatic effect, surface hydrophilic lubricity, flexibility, biocompatibility and
Comfort is excellent, is intubated easy medical retention conduit and is accorded with the demands of the market with material, has extensive market value and application
Prospect.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provides a kind of antibacterial super slippery medical retention conduit material, should
Medical retention conduit material preparation method is simple to operation, not high to device dependence, and raw material is easy to get, cheap, is suitble to
Large-scale production, Clinical practicability are stronger；The medical retention conduit material being prepared has sustained anti-microbial fungistatic effect, table
Face Hydrophilic lubrication, flexibility, biocompatibility and the excellent advantage of comfort, the medical retention conduit made of this material are inserted
Tube capacity is easy, effectively increases therapeutic effect, alleviates the pain of patient.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of antibacterial super slippery medical retention conduit is used
Material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids and and thiazolidine -2,4-
The polyetheramine D-2000 of the amount of the substances such as dicarboxylic acids is dissolved in deionized water, is placed in autoclave, nitrogen or indifferent gas
Body purging after, by temperature in autoclave be maintained at 270-300 DEG C, pressure be maintained at 3.0-5.0MPa, be stirred to react 6-8h,
Then in slowly exhaust is depressurized to 1.0MPa in 2 hours, while reaction under high pressure temperature in the kettle is warming up to 305-315 DEG C, then
Under nitrogen environment or vacuum condition, temperature is controlled between 230-260 DEG C, 12-15h is stirred to react, obtains polyetheramine thiazole
Alkane -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline and 2,6- bis- (4- nitrine benzylidene) -4 methyl cyclohexanones
It is added in high boiling solvent, is heated to 45-55 DEG C, cupric sulfate pentahydrate, ascorbic acid and water are added when being vigorously stirred, keep the temperature
Reaction 18-24 hours, is carefully poured out reaction solution after reaction, and gluey solid stays in flask, adds in backward flask
Enter the water and concentrated ammonia liquor that volume ratio is 5:1, be stirred for 2-4 hours, filters, filter cake is washed with water 3-5 times, then solid is dissolved in N, N-
In dimethylformamide, filtrate is settled out in water after filtering, and polymer 3-5 times be precipitated with ethanol washing is finally placed in vacuum
It is dried at 80-90 DEG C to constant weight in drying box；
The ionization of III condensation polymer: the condensation polymer, the basic catalyst that are prepared by step II are dissolved in N- methylpyrrole
In alkanone, then 2- chloromethyl -1,1- dioxo -1,2- dihydro -1lambda* with amounts of substances such as condensation polymers is added thereto
6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 10-12 hours at 40-50 DEG C, after analyse in water
Out, polymer 3-6 times be precipitated with ethanol washing is finally placed in a vacuum drying oven at 85-95 DEG C and dries to constant weight；
The molding of IV conduit material: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide pass through
Condensation polymer, the alginic acid for the ionization that step III is prepared, which are added in double screw extruder, carries out extrusion molding, is cured
With inlying catheter material.
Preferably, thiazolidine -2 described in step I, 4- dicarboxylic acids, deionized water mass ratio be 1:(10-20).
Preferably, the inert gas is selected from one of helium, neon, argon gas.
Preferably, N described in step II, N- dipropargyl aniline, 2,6- bis- (4- nitrine benzylidene) -4 methyl cyclohexanes
Ketone, high boiling solvent, cupric sulfate pentahydrate, ascorbic acid, water mass ratio be 1:2.19:(10-15): 0.83:0.71:(5-
10)。
Preferably, the high boiling solvent is selected from dimethyl sulfoxide, n,N-Dimethylformamide, N-Methyl pyrrolidone, N,
One or more of N- dimethyl acetamide.
Preferably, condensation polymer described in step III, N-Methyl pyrrolidone, basic catalyst mass ratio be 1:(10-
15):(0.3-0.5)。
Preferably, the basic catalyst is selected from one of sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide or several
Kind.
Preferably, polyetheramine thiazolidine -2 described in step IV, 4- dicarboxylic acids amide, the condensation polymer of ionization, alginic acid
Mass ratio be 1:1:0.3.
Preferably, the extrusion molding process are as follows: extrusion temperature is 235-255 DEG C, screw speed 1100-1300r/
min。
Further, a kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
The beneficial effects of adopting the technical scheme are that
1) antibacterial super slippery medical retention conduit material provided by the invention, preparation method is simple to operation, to equipment according to
Bad property is not high, and raw material is easy to get, cheap, is suitble to large-scale production, and Clinical practicability is stronger.
2) antibacterial super slippery medical retention conduit material provided by the invention has sustained anti-microbial fungistatic effect, surface parent
Water lubrication, flexibility, biocompatibility and the excellent advantage of comfort, the medical retention intubation catheter made of this material hold
Easily, therapeutic effect is effectively increased, the pain of patient is alleviated.
3) antibacterial super slippery medical retention conduit material provided by the invention, material of main part use antimicrobial form condensation polymer, gather
Ether amines thiazolidine -2, the blending of 4- dicarboxylic acids amide are made, and have taken into account the advantage of two kinds of polymer, and by the way that alginic acid is added, with
Condensation polymer is connected by ion exchange, and by hydroxyl and polyetheramine thiazolidine -2, reaction exists between 4- dicarboxylic acids amide carboxyl end group
Formative stage links together, so that various composition forms organic whole, improves the comprehensive performance of material；Polyetheramine thiazole
Alkane -2,4- dicarboxylic acids amide introduces polyetheramine segment, and the segment acts synergistically on molecular backbone with the alginic acid of addition,
The biocompatibility of material is improved, so that material surface hydrophily enhances, and then improves the surface superslide of material, reduces conduit
Patient's bring pain is given when insertion；Condensation polymer introduces thiazole structure by ionization, cooperates with work with aniline structure and alginic acid
With the good antibiotic property of imparting material, since these structures are connected on strand in the form of functional group, so that antibiotic property point
Cloth is uniform, and stability is good；In addition this body structure of these ingredients determine its with the mechanical properties such as excellent elasticity and weatherability and
Chemically-resistant is stablized.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Present invention raw material as used in the following examples is purchased from shellfish (Shanghai) Biotechnology Co., Ltd that rubs.
Embodiment 1
A kind of antibacterial super slippery medical retention conduit material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids 1kg and with thiazolidine-
The polyetheramine D-2000 of the amount of the substances such as 2,4- dicarboxylic acids is dissolved in deionized water 10kg, is placed in autoclave, nitrogen
After purging, by temperature in autoclave be maintained at 270 DEG C, pressure be maintained at 3.0MPa, 6h is stirred to react, then in 2 hours
Interior slow exhaust is depressurized to 1.0MPa, while reaction under high pressure temperature in the kettle is warming up to 305 DEG C, then in a nitrogen environment, control
Temperature processed is stirred to react 12h between 230 DEG C, obtains polyetheramine thiazolidine -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline 1kg and 2,6- bis- (4- nitrine benzylidene) -4 methyl rings
Hexanone 2.19kg is added in dimethyl sulfoxide 10kg, is heated to 45 DEG C, and cupric sulfate pentahydrate 0.83kg is added when being vigorously stirred, resists
Insulation reaction 18 hours, reaction solution was carefully poured out in bad hematic acid 0.71kg and water 5kg after reaction, and gluey solid is stayed
The water and concentrated ammonia liquor that volume ratio is 5:1 are added in flask, in backward flask, is stirred for 2 hours, filters, filter cake is washed with water 3
It is secondary, then solid is dissolved in n,N-Dimethylformamide, filtrate is settled out in water after filtering, the polymer being precipitated with ethanol washing
It 3 times, is finally placed in a vacuum drying oven at 80 DEG C and dries to constant weight；
The ionization of III condensation polymer: the condensation polymer 1kg, the sodium carbonate 0.3kg that are prepared by step II are dissolved in N- methyl
In pyrrolidones 10kg, then 2- chloromethyl -1,1- dioxo -1,2- dihydro-with amounts of substances such as condensation polymers is added thereto
1lambda*6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 10 hours at 40 DEG C, after in water
It is precipitated, polymer 3 times be precipitated with ethanol washing, is finally placed in a vacuum drying oven at 85 DEG C and dries to constant weight；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide 1kg, warp
Cross the condensation polymer 1kg for the ionization that step III is prepared, alginic acid 0.3kg is added in double screw extruder and is extruded into
Type obtains medical retention conduit material；The extrusion molding process are as follows: extrusion temperature is 235 DEG C, screw speed 1100r/
min。
A kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
Embodiment 2
A kind of antibacterial super slippery medical retention conduit material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids 1kg and with thiazolidine-
The polyetheramine D-2000 of the amount of the substances such as 2,4- dicarboxylic acids is dissolved in deionized water 11kg, is placed in autoclave, helium
After purging, by temperature in autoclave be maintained at 280 DEG C, pressure be maintained at 3.5MPa, be stirred to react 6.5h, it is then small in 2
When interior slow exhaust be depressurized to 1.0MPa, while reaction under high pressure temperature in the kettle is warming up to 308 DEG C, then under vacuum conditions,
Temperature is controlled between 235 DEG C, 12.5h is stirred to react, obtains polyetheramine thiazolidine -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline 1kg and 2,6- bis- (4- nitrine benzylidene) -4 methyl rings
Hexanone 2.19kg is added in n,N-Dimethylformamide 11.5kg, is heated to 47 DEG C, and five water sulfuric acid are added when being vigorously stirred
Insulation reaction 19 hours, reaction solution, glue was carefully poured out in copper 0.83kg, ascorbic acid 0.71kg and water 6kg after reaction
Shape solid stays in flask, and water and concentrated ammonia liquor that volume ratio is 5:1 are added in backward flask, is stirred for 2.5 hours, filters,
Filter cake is washed with water 4 times, then solid is dissolved in n,N-Dimethylformamide, and filtrate is settled out in water after filtering, uses ethanol washing
The polymer of precipitation 4 times is finally placed in a vacuum drying oven at 83 DEG C and dries to constant weight；
The ionization of III condensation polymer: the condensation polymer 1kg, the potassium carbonate 0.35kg that are prepared by step II are dissolved in N- methyl
In pyrrolidones 12kg, then 2- chloromethyl -1,1- dioxo -1,2- dihydro-with amounts of substances such as condensation polymers is added thereto
1lambda*6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 11 hours at 43 DEG C, after in water
It is precipitated, polymer 4 times be precipitated with ethanol washing, is finally placed in a vacuum drying oven at 88 DEG C and dries to constant weight；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide 1kg, warp
Cross the condensation polymer 1kg for the ionization that step III is prepared, alginic acid 0.3kg is added in double screw extruder and is extruded into
Type obtains medical retention conduit material；The extrusion molding process are as follows: extrusion temperature is 240 DEG C, screw speed 1150r/
min。
A kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
Embodiment 3
A kind of antibacterial super slippery medical retention conduit material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids 1kg and with thiazolidine-
The polyetheramine D-2000 of the amount of the substances such as 2,4- dicarboxylic acids is dissolved in deionized water 15kg, is placed in autoclave, neon
After purging, by temperature in autoclave be maintained at 285 DEG C, pressure be maintained at 4.0MPa, 7h is stirred to react, then in 2 hours
Interior slow exhaust is depressurized to 1.0MPa, while reaction under high pressure temperature in the kettle is warming up to 310 DEG C, then in a nitrogen environment, control
Temperature processed is stirred to react 13.5h between 245 DEG C, obtains polyetheramine thiazolidine -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline 1kg and 2,6- bis- (4- nitrine benzylidene) -4 methyl rings
Hexanone 2.19kg is added in N-Methyl pyrrolidone 13kg, is heated to 50 DEG C, cupric sulfate pentahydrate is added when being vigorously stirred
Insulation reaction 21 hours, reaction solution was carefully poured out in 0.83kg, ascorbic acid 0.71kg and water 8kg after reaction, gluey
Solid stays in flask, and water and concentrated ammonia liquor that volume ratio is 5:1 are added in backward flask, is stirred for 3 hours, filters, filter cake
It is washed with water 4 times, then solid is dissolved in n,N-Dimethylformamide, filtrate is settled out in water after filtering, is precipitated with ethanol washing
Polymer 4 times, be finally placed in a vacuum drying oven at 86 DEG C and dry to constant weight；
The ionization of III condensation polymer: the condensation polymer 1kg, the sodium hydroxide 0.4kg that are prepared by step II are dissolved in N- first
In base pyrrolidones 13kg, then 2- chloromethyl -1,1- dioxo -1,2- bis- with amounts of substances such as condensation polymers is added thereto
Hydrogen -1lambda*6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 11 hours at 45 DEG C, after
It is precipitated in water, polymer 5 times be precipitated with ethanol washing, is finally placed in a vacuum drying oven at 90 DEG C and dries to constant weight；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide 1kg, warp
Cross the condensation polymer 1kg for the ionization that step III is prepared, alginic acid 0.3kg is added in double screw extruder and is extruded into
Type obtains medical retention conduit material；The extrusion molding process are as follows: extrusion temperature is 245 DEG C, screw speed 1200r/
min。
A kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
Embodiment 4
A kind of antibacterial super slippery medical retention conduit material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids 1kg and with thiazolidine-
The polyetheramine D-2000 of the amount of the substances such as 2,4- dicarboxylic acids is dissolved in deionized water 18kg, is placed in autoclave, argon gas
After purging, by temperature in autoclave be maintained at 290 DEG C, pressure be maintained at 4.5MPa, be stirred to react 7.5h, it is then small in 2
When interior slow exhaust be depressurized to 1.0MPa, while reaction under high pressure temperature in the kettle is warming up to 313 DEG C, then under vacuum conditions,
Temperature is controlled between 255 DEG C, 14h is stirred to react, obtains polyetheramine thiazolidine -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline 1kg and 2,6- bis- (4- nitrine benzylidene) -4 methyl rings
Hexanone 2.19kg is added in high boiling solvent 14.5kg, is heated to 53 DEG C, cupric sulfate pentahydrate is added when being vigorously stirred
Insulation reaction 23 hours, reaction solution was carefully poured out in 0.83kg, ascorbic acid 0.71kg and water 8kg after reaction, gluey
Solid stays in flask, and water and concentrated ammonia liquor that volume ratio is 5:1 are added in backward flask, is stirred for 3.5 hours, filters, filter
Cake is washed with water 5 times, then solid is dissolved in n,N-Dimethylformamide, and filtrate is settled out in water after filtering, is analysed with ethanol washing
Polymer out 5 times is finally placed in a vacuum drying oven at 88 DEG C and dries to constant weight；The high boiling solvent be dimethyl sulfoxide,
The mixing that N,N-dimethylformamide, N-Methyl pyrrolidone, DMAC N,N' dimethyl acetamide 1:2:3:2 in mass ratio are mixed
Object；
The ionization of III condensation polymer: the condensation polymer 1kg, the basic catalyst 0.45kg that are prepared by step II are dissolved in N-
In methyl pyrrolidone 14.5kg, then 2- chloromethyl -1,1- dioxo -1,2- with amounts of substances such as condensation polymers is added thereto
Dihydro -1lambda*6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 11.5 hours at 48 DEG C,
It is precipitated in water afterwards, polymer 6 times be precipitated with ethanol washing, is finally placed in a vacuum drying oven at 93 DEG C and dries to constant weight；
The basic catalyst is the mixing that sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide 2:1:2:3 in mass ratio are mixed
Object；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide 1kg, warp
Cross the condensation polymer 1kg for the ionization that step III is prepared, alginic acid 0.3kg is added in double screw extruder and is extruded into
Type obtains medical retention conduit material；The extrusion molding process are as follows: extrusion temperature is 253 DEG C, screw speed 1250r/
min。
A kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
Embodiment 5
A kind of antibacterial super slippery medical retention conduit material, by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids 1kg and with thiazolidine-
The polyetheramine D-2000 of the amount of the substances such as 2,4- dicarboxylic acids is dissolved in deionized water 20kg, is placed in autoclave, nitrogen
After purging, by temperature in autoclave be maintained at 300 DEG C, pressure be maintained at 5.0MPa, 8h is stirred to react, then in 2 hours
Interior slow exhaust is depressurized to 1.0MPa, while reaction under high pressure temperature in the kettle is warming up to 315 DEG C, then in a nitrogen environment, control
Temperature processed is stirred to react 15h between 260 DEG C, obtains polyetheramine thiazolidine -2,4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline 1kg and 2,6- bis- (4- nitrine benzylidene) -4 methyl rings
Hexanone 2.19kg is added in n,N-dimethylacetamide 15kg, is heated to 55 DEG C, cupric sulfate pentahydrate is added when being vigorously stirred
Insulation reaction 24 hours, reaction solution, glue was carefully poured out in 0.83kg, ascorbic acid 0.71kg and water 10kg after reaction
Shape solid stays in flask, and water and concentrated ammonia liquor that volume ratio is 5:1 are added in backward flask, is stirred for 4 hours, filters, filter
Cake is washed with water 5 times, then solid is dissolved in n,N-Dimethylformamide, and filtrate is settled out in water after filtering, is analysed with ethanol washing
Polymer out 5 times is finally placed in a vacuum drying oven at 90 DEG C and dries to constant weight；
The ionization of III condensation polymer: the condensation polymer 1kg, the potassium hydroxide 0.5kg that are prepared by step II are dissolved in N- first
In base pyrrolidones 15kg, then 2- chloromethyl -1,1- dioxo -1,2- bis- with amounts of substances such as condensation polymers is added thereto
Hydrogen -1lambda*6*- benzo [d] isothiazole -3- ketone (CAS:13947-21-2), is stirred to react 12 hours at 50 DEG C, after
It is precipitated in water, polymer 6 times be precipitated with ethanol washing, is finally placed in a vacuum drying oven at 95 DEG C and dries to constant weight；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide 1kg, warp
Cross the condensation polymer 1kg for the ionization that step III is prepared, alginic acid 0.3kg is added in double screw extruder and is extruded into
Type obtains medical retention conduit material；The extrusion molding process are as follows: extrusion temperature is 255 DEG C, screw speed 1300r/
min。
A kind of medical retention conduit is prepared using above-mentioned antibacterial super slippery medical retention conduit with material.
Comparative example
A kind of bacteriostatic ultra-smooth medical indwelling catheter, according to the preparation of 102247647 A embodiment 1 of Chinese invention patent CN
Method is prepared.
Bacteriostatic ultra-smooth medical indwelling catheter obtained by above-described embodiment 1-5 and comparative example is tested for the property, test side
Method and test result are shown in Table 1.
Table 1
As seen from Table 1, bacteriostatic ultra-smooth medical indwelling catheter disclosed by the embodiments of the present invention, compared with comparison, antibiotic property and
Biocompatibility is more preferable, and mechanical property is more excellent.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its
Equivalent thereof.
Claims (10)
1. a kind of antibacterial super slippery medical retention conduit material, which is characterized in that by being made following preparation method:
I polyetheramine thiazolidine -2, the preparation of 4- dicarboxylic acids amide: by thiazolidine -2,4- dicarboxylic acids and and thiazolidine -2,4- dicarboxyl
The polyetheramine D-2000 of the amount of the substances such as acid is dissolved in deionized water, is placed in autoclave, nitrogen or inert blowing gas
After sweeping, by temperature in autoclave be maintained at 270-300 DEG C, pressure be maintained at 3.0-5.0MPa, be stirred to react 6-8h, then
It is depressurized to 1.0MPa in being slowly vented in 2 hours, while reaction under high pressure temperature in the kettle is warming up to 305-315 DEG C, then in nitrogen
Under compression ring border or vacuum condition, temperature is controlled between 230-260 DEG C, 12-15h is stirred to react, obtains polyetheramine thiazolidine -2,
4- dicarboxylic acids amide；
The preparation of II condensation polymer: by N, N- dipropargyl aniline and (4- nitrine benzylidene) -4 methyl cyclohexanones of 2,6- bis- are added
Into high boiling solvent, it is heated to 45-55 DEG C, cupric sulfate pentahydrate, ascorbic acid and water, insulation reaction are added when being vigorously stirred
18-24 hours, reaction solution is carefully poured out after reaction, gluey solid stays in flask, and body is added in backward flask
Product is stirred for 2-4 hours than the water and concentrated ammonia liquor that are 5:1, is filtered, filter cake is washed with water 3-5 times, then solid is dissolved in N, N- diformazan
In base formamide, filtrate is settled out in water after filtering, and polymer 3-5 times be precipitated with ethanol washing is finally placed in vacuum drying
It is dried at 80-90 DEG C to constant weight in case；
The ionization of III condensation polymer: the condensation polymer, the basic catalyst that are prepared by step II are dissolved in N-Methyl pyrrolidone
In, then 2- chloromethyl -1,1- dioxo -1,2- dihydro -1lambda*6*- benzene with amounts of substances such as condensation polymers is added thereto
And [d] isothiazole -3- ketone (CAS:13947-21-2), be stirred to react at 40-50 DEG C 10-12 hours, after be precipitated in water, use
Polymer 3-6 times of ethanol washing precipitation is finally placed in a vacuum drying oven at 85-95 DEG C and dries to constant weight；
IV conduit material molding: the polyetheramine thiazolidine -2 that will be prepared by step I, 4- dicarboxylic acids amide, by step
Condensation polymer, the alginic acid of III ionization being prepared, which are added in double screw extruder, carries out extrusion molding, obtains medical stay
Set conduit material.
2. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that institute in step I
State thiazolidine -2,4- dicarboxylic acids, deionized water mass ratio be 1:(10-20).
3. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that the indifferent gas
Body is selected from one of helium, neon, argon gas.
4. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that institute in step II
State N, N- dipropargyl aniline, 2,6- bis- (4- nitrine benzylidene) -4 methyl cyclohexanones, high boiling solvent, cupric sulfate pentahydrate,
Ascorbic acid, water mass ratio be 1:2.19:(10-15): 0.83:0.71:(5-10).
5. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that the higher boiling
Solvent is selected from one of dimethyl sulfoxide, N,N-dimethylformamide, N-Methyl pyrrolidone, DMAC N,N' dimethyl acetamide or several
Kind.
6. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that institute in step III
State condensation polymer, N-Methyl pyrrolidone, basic catalyst mass ratio be 1:(10-15): (0.3-0.5).
7. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that the alkalinity is urged
Agent is selected from one or more of sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide.
8. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that institute in step IV
State polyetheramine thiazolidine -2,4- dicarboxylic acids amide, the condensation polymer of ionization, alginic acid mass ratio be 1:1:0.3.
9. a kind of antibacterial super slippery medical retention conduit material according to claim 1, which is characterized in that described to be extruded into
Type technique are as follows: extrusion temperature is 235-255 DEG C, screw speed 1100-1300r/min.
10. -9 described in any item a kind of doctors that antibacterial super slippery medical retention conduit is prepared with material according to claim 1
Use inlying catheter.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110591273A (en) * | 2019-09-16 | 2019-12-20 | 浙江派菲特新材料科技有限公司 | Preparation method of antibacterial anti-adhesion medical glue smearing straw |
| CN110694477A (en) * | 2019-10-09 | 2020-01-17 | 宁波泰意德过滤技术有限公司 | Antibacterial nanofiltration membrane and preparation method thereof |
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