CN109567931A - A kind of replaceable laser probe and device for laser therapy of the end with optothermal material - Google Patents
A kind of replaceable laser probe and device for laser therapy of the end with optothermal material Download PDFInfo
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- CN109567931A CN109567931A CN201811494079.2A CN201811494079A CN109567931A CN 109567931 A CN109567931 A CN 109567931A CN 201811494079 A CN201811494079 A CN 201811494079A CN 109567931 A CN109567931 A CN 109567931A
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- laser
- optical fiber
- laser probe
- optothermal material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B2018/2205—Characteristics of fibres
- A61B2018/2222—Fibre material or composition
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- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The present invention provides a kind of replaceable laser probe and laser therapeutic system of the end with optothermal material, by the fiber end face in cutter head, optothermal material is set, the optothermal material covering part fiber end face, in this way, the efficient photothermal conversion of optothermal material improves the Thermogenesis of probe, improve fiber optic temperature, but the output of laser is not influenced, improve temperature, contact surgical operation is carried out again, the high temperature and laser of cutter head tip act on tissue simultaneously and procedure efficiency are greatly improved, required laser power is many compared to the decline of traditional fiber non-contact method, reduce the generation of optical fiber fuel factor problem, and the laser probe is changeable type structure, after first use, replace cutter head, without replacement operation optical fiber, it is greatly saved consuming cost.
Description
Technical field
The present invention relates to area of medical devices, and in particular to a kind of replaceable laser probe of the end with optothermal material and
Device for laser therapy.
Background technique
Laser is because of extraordinary cutting power, good coagulating effectiveness and lesser thermal damage, in surgical field
It gets the attention.The high energy pulse laser that laser generates, is passed out by optical fiber, and optical fiber is entered by endoscope again
Human body, by the incoming position for needing laser therapy of the energy of laser, using the high energy, collimation, action time of laser it is short and
The features such as heat-affected zone is small carries out treatment effectively and safely for patient.Laser is doctor to the interaction of bio-tissue
The physical basis of application is learned, the fuel factor of laser is medically to imitate using the laser tissue being most recognized extensively and earliest
One of answer.Laser light incident bio-tissue, within the scope of light penetration depth, absorbed luminous energy is converted into heat.When heating speed
Needed for degree (thermal energy comes from laser irradiation, related with laser intensity and two factors of tissue absorption coefficient) significantly larger than evaporation tissue
The speed of heat, then tissue is by vaporization quickly.
The laser of the exportable 1.65~2.1um wavelength of thulium-doped fiber laser is widest in all rare earth ions, phase
For solid state laser, have that structure is simple, high-efficient, heat dissipation characteristics are good, narrow linewidth, quality for outputting laser beam height etc. are excellent
Point, thus the thulium optical fiber laser of high peak power pulse output had obtained extensive research in recent years.But thulium is mixed near 2 μm
Optical fiber laser the operations such as is cut to tissue, is gasified and needing biggish pulse energy, and laser power is mainly by mixing thulium
Fibre core provides.But with the significant reinforcement for mixing optical power density in thulium gain fibre, it may appear that serious fuel factor causes thermotropic
Phenomena such as birefringent, phase distortion, hot focus, thermal lens, seriously affects the output power and beam quality of laser, becomes limitation
The lethal factor that laser performance improves.
The Chinese invention patent of Publication No. CN104638506A discloses 1.9 microns of high-power prostate laser of one kind and controls
Instrument is treated, the compensation of different modes can be carried out for different operation power, solves thulium-doped fiber laser to increase power
And there is the problems such as efficiency decline and beam quality variation.But this scheme still can not solve the problems, such as the fuel factor of optical fiber.
CN107412957A discloses a kind of photo-thermal therapy probe based on photo-thermal nano material comprising closed at one end
Cylinder-like shell, the photo-thermal nano material for being filled in interior of shell closed end kill tumour and other diseases by implementing high temperature
Become histocyte.But this scheme is implemented to treat only with high temperature, and it closes nano material inside the shell, knot
Structure is complicated, heat production low efficiency.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of end and controls with the replaceable laser probe and laser of optothermal material
Device is treated, optothermal material, the optothermal material covering part fiber end face, in this way, light are arranged by the fiber end face in cutter head
The efficient photothermal conversion of hot material improves the Thermogenesis of probe, improves fiber optic temperature, but does not influence the output of laser, improves
Temperature, then contact surgical operation is carried out, acting on tissue makes procedure efficiency significantly simultaneously for the high temperature and laser of cutter head tip
It improves, required laser power is many compared to the decline of traditional fiber non-contact method, reduces the hair of optical fiber fuel factor problem
It is raw, and the laser probe is changeable type structure, after first use, replaces cutter head, does not have to replacement operation optical fiber, greatly
Save consuming cost.
Technical solution of the present invention specifically:
A kind of replaceable laser probe of the end with optothermal material, which is characterized in that the laser probe includes light light
Fibre is formed with optothermal material in the distal end faces of the light-coming out optical fiber, the optothermal material covering fiber end face 5%~60%
Area, the laser probe are removably connect with operation optical fiber.The optothermal material covering part fiber end face, in this way, light
The efficient photothermal conversion of hot material improves the Thermogenesis of probe, improves fiber optic temperature, but does not influence the output of laser.It is described
The covering shape of optothermal material can be arranged according to actual needs, for example can be circle, annulus, spot distribution, threadiness, put
Penetrate shapes such as shape or combinations thereof.
The optothermal material can pass through any one method shape in coating, vapor deposition, magnetron sputtering, vapor deposition, welding
The surface of optical fiber described in Cheng Yu.Welding carries out under protective atmosphere, using the atmosphere by He gas composition, can effectively prevent in this way
The only oxidation of material under high temperature.
It is preferred that the area control of the optothermal material covering fiber end face is especially preferred 30%~50% with 35%.This
Sample, the outgoing of influence laser that will not be too many, can improve the Thermogenesis of probe, improve fiber optic temperature, but do not influence to swash
The output of light.
The laser probe is detachably connected with the realization that is connected through a screw thread or is connected together of operation optical fiber.
Sheath of the laser probe with covering service aisle.The sheath optical fiber that can cover and perform the operation is used cooperatively
Endoscope service aisle, can prevent steam from entering service aisle, prevent the pollution to service aisle.
The sheath is made of elastic material, it is preferred to use rubber material is made.
The optothermal material can be one of metal optothermal material, diamond or semiconductor light hot material or a variety of.
The photo-thermal nano material can be metal photo-thermal nano material, Nano diamond or semiconductor photo-thermal nano material
One of or it is a variety of.
The metal photo-thermal nano material can be one of gold, platinum, nanometer Pd material or a variety of.
The semiconductor photo-thermal nano material can for copper sulfide, molybdenum sulfide, bismuth sulfide, antimony trisulfide, aurosulfo copper selenide,
One of selenizing molybdenum, bismuth selenide, antimony selenide or Auric selenide are a variety of.
According to the density and thickness that optothermal material is arranged needed for laser power and clinical temperature.For example, thickness can be
100 microns hereinafter, further, 50 microns hereinafter, further, 1 micron hereinafter, further, 500 nanometers or less and not small
In 1 nanometer.
The present invention further provides a kind of optical-fiber laser therapeutic device that laser probe is replaceable, described device includes interior peeps
Mirror, perform the operation optical fiber and laser probe as described above, are provided with service aisle in the endoscope, the laser probe is with hand
Art optical fiber removably connects, and the operation optical fiber can move axially in service aisle, and the laser probe is with covering
The sheath of service aisle.
The laser probe is connected through a screw thread or is connected together with operation optical fiber.
Protrude endoscope tip plane certain length, the fixation for the sheath in the service aisle edge.
Optionally, the service aisle bordered profiles circularize the fixation that recess is used for the sheath.
The operation optical fiber can be axially moveable in the service aisle of endoscope, and the service aisle front end is provided with
With the bayonet of operation optical fiber cooperation, the bayonet includes the elastic brake lining for closing bayonet, and bayonet outer is provided with control brake lining
Switch, open brake lining, the operation optical fiber can stretch out bayonet, connect with the cutter head, after treatment end, to the cutter head
And the sheath is cleaned, and the connection of the cutter head and optical fiber of performing the operation is released, and the operation optical fiber is withdrawn bayonet, brake lining is certainly
It moves back, closes bayonet, then release being fixedly connected for the sheath and service aisle, in this way, only being needed internal after primary operation
Disinfection is purged outside sight glass, without carrying out cleaning and sterilizing to endoscopic working channel.
The shape of the brake lining can according to need setting, can be two semicircle brake linings, or multiple triangles
Blade.
Further, described device includes the temperature sensor being arranged near optic fibre end, is monitored to temperature.
Further, described device includes cooling and flushing channel, is used for by liquid injection to target site, to target portion
It is cleaned and is cooled down in position.
Be compared with the prior art, the present invention there are following the utility model has the advantages that
1, probe gets involved in lesion tissue position by minimally invasive, then passes through the efficient photothermal conversion mechanism of optothermal material, leads to
Raising fiber optic temperature is crossed, then carries out optical Fiber Contact surgical operation, the high temperature and laser of fiber tip, which act on tissue simultaneously, to be made
It obtains procedure efficiency to greatly improve, has laser surgey high energy, collimation, the feature that action time is short and heat-affected zone is small, together
The laser power of Shi Suoxu is many compared to the decline of traditional fiber non-contact method, reduces the hair of the fuel factor problem of optical fiber
It is raw.
2, optical fiber is directly contacted with optothermal material in the present invention, and structure is simple, in addition also greatly reduces laser energy
Loss.
3, system complexity is low.Since this product power is low, and when work, other parts temperature will not be risen other than syringe needle
Height, so not needing water-cooling system.So greatly reducing system complexity.
4, laser probe uses changeable type structure, after first use, replaces cutter head, does not have to replacement operation optical fiber,
It is greatly saved consuming cost.
Detailed description of the invention
Fig. 1 is laser probe structural schematic diagram;
Fig. 2 is that optical fiber connector end face optothermal material circular ring shape covers schematic diagram;
Fig. 3 is the dotted covering schematic diagram of optical fiber connector end face optothermal material;
Fig. 4 is optical-fiber laser therapeutic device structural schematic diagram;
In figure, 1 is light-coming out optical fiber, and 2 be laser probe shell, and 3 be sheath, and 4 be optothermal material, and 5 be laser probe, and 6 are
Endoscope, 7 be endoscopic working channel, and 8 be operation optical fiber.
Specific embodiment
In order to be more clear goal of the invention of the invention, technical solution and advantageous effects, with reference to embodiments,
The present invention will be described in further detail.It should be understood that embodiment described in this specification is just for the sake of explanation
The present invention, be not intended to limit the present invention, embodiment design parameter setting etc. can adaptation to local conditions make a choice and simultaneously to result
Without substantial effect.
Embodiment 1
As shown in Figure 1, the present invention provides a kind of replaceable laser probe of the end with optothermal material, the laser probe packet
Light-coming out optical fiber 1 is included, optothermal material is formed in the distal end faces of the light-coming out optical fiber 1, the laser probe and operation optical fiber 8 can
The connection of disassembly.The 5% of the optothermal material covering fiber end face area, in this way, the efficient photothermal conversion of optothermal material improves
The Thermogenesis of probe improves fiber optic temperature, but does not influence the output of laser.
The optothermal material is gold nanosphere.The metal nano optothermal material is formed in the table of the optical fiber by welding
Face.Optical fiber connector is contacted with gold nanosphere, carries out welding.There are three types of the modes of heating and fusing: arc welding;Clear flame is molten
It connects;Laser welding.Welding carries out under protective atmosphere, and using the atmosphere by He gas composition, high temperature can be effectively prevented in this way
The oxidation of lower material.
The covering shape of the optothermal material is as shown in Fig. 2, for circular ring shape, and 4 be optothermal material in figure.
The thickness of optothermal material can be 100 microns hereinafter, further, 50 microns hereinafter, further, 1 micron with
Under, further, 500 nanometers or less and be not less than 1 nanometer.
Fig. 4 is the optical-fiber laser therapeutic device using this kind of laser probe, and described device includes endoscope 6, operation optical fiber
8, the laser probe, service aisle 7 is provided in the endoscope, and the operation optical fiber 8 is arranged in the service aisle 7
Interior, the laser probe can removably be connected with operation optical fiber 8, and the operation optical fiber 8 can move in service aisle 7
It is dynamic, sheath of the laser probe with covering service aisle 7.
The laser probe is connected through a screw thread connection with operation optical fiber 8.
7 edge of service aisle protrudes endoscope tip plane certain length, and service aisle bordered profiles circularize recess,
Fixation for the sheath.
Operation optical fiber 8 can be axially moveable in the service aisle 7 of endoscope 6, and 7 front end of service aisle is provided with and hand
The bayonet of art optical fiber cooperation, the bayonet include the elastic brake lining for closing bayonet, and bayonet outer is provided with opening for control brake lining
It closes, opens brake lining, the operation optical fiber can stretch out bayonet, connect with the cutter head, after treatment end, to the cutter head and institute
It states sheath to be cleaned, releases the connection of the cutter head and optical fiber of performing the operation, the operation optical fiber is withdrawn into bayonet, brake lining appliance for releasing single
It returns, closes bayonet, then release being fixedly connected for the sheath and service aisle, in this way, after primary operation, it only need to be to endoscope
Disinfection is purged outside 6, without carrying out cleaning and sterilizing to endoscopic working channel 7.
The shape of the brake lining can according to need setting, can be two semicircle brake linings, or multiple triangles
Blade.
Embodiment 2
As shown in Figure 1, the present invention provides a kind of replaceable laser probe of the end with optothermal material, the laser probe packet
Light-coming out optical fiber 1 is included, optothermal material is formed in the distal end faces of the light-coming out optical fiber 1, the laser probe and operation optical fiber 8 can
The connection of disassembly.The area of the optothermal material covering fiber end face 60%, in this way, the efficient photothermal conversion of optothermal material improves
The Thermogenesis of probe improves fiber optic temperature, but does not influence the output of laser.
The optothermal material is diamond nano optothermal material.The diamond nano optothermal material passes through magnetron sputtering
Mode is formed in the surface of the optical fiber.
The covering shape of the optothermal material is as shown in figure 3, in spot distribution, and 4 be optothermal material in figure.
According to the density and thickness that optothermal material is arranged needed for laser power and clinical temperature.For example, thickness can be
100 microns hereinafter, further, 50 microns hereinafter, further, 1 micron hereinafter, further, 500 nanometers or less and not small
In 1 nanometer.
Fig. 4 is the optical-fiber laser therapeutic device using this kind of laser probe, and described device includes endoscope 6, operation optical fiber
8, laser probe is provided with service aisle 7 in the endoscope, and the operation optical fiber 8 is arranged in the service aisle 7, institute
Stating laser probe can removably connect with operation optical fiber 8, and the operation optical fiber 8 can move in service aisle 7, described
Sheath of the laser probe with covering service aisle 7.
The laser probe is connected with operation optical fiber 8 by snap fit.
7 edge of service aisle protrudes endoscope tip plane certain length, and service aisle bordered profiles circularize recess,
Fixation for the sheath.
Operation optical fiber 8 can be axially moveable in the service aisle 7 of endoscope 6, and 7 front end of service aisle is provided with and hand
The bayonet of art optical fiber cooperation, the bayonet include the elastic brake lining for closing bayonet, and bayonet outer is provided with opening for control brake lining
It closes, opens brake lining, the operation optical fiber can stretch out bayonet, connect with the cutter head, after treatment end, to the cutter head and institute
It states sheath to be cleaned, releases the connection of the cutter head and optical fiber of performing the operation, the operation optical fiber is withdrawn into bayonet, brake lining appliance for releasing single
It returns, closes bayonet, then release being fixedly connected for the sheath and service aisle, in this way, after primary operation, it only need to be to endoscope
Disinfection is purged outside 6, without carrying out cleaning and sterilizing to endoscopic working channel 7.
The shape of the brake lining can according to need setting, can be two semicircle brake linings, or multiple triangles
Blade.
Embodiment 3
As shown in Figure 1, the present invention provides a kind of replaceable laser probe of the end with optothermal material, the laser probe packet
Light-coming out optical fiber 1 is included, optothermal material is formed in the distal end faces of the light-coming out optical fiber 1, the laser probe and operation optical fiber 8 can
The connection of disassembly.The 35% of the optothermal material covering fiber end face area, in this way, the efficient photothermal conversion of optothermal material improves
The Thermogenesis of probe improves fiber optic temperature, but does not influence the output of laser.
The optothermal material is gold nanosphere.The metal nano optothermal material is formed in the table of the optical fiber by welding
Face.Optical fiber connector is contacted with gold nanosphere, carries out welding.There are three types of the modes of heating and fusing: arc welding;Clear flame is molten
It connects;Laser welding.Welding carries out under protective atmosphere, and using the atmosphere by He gas composition, high temperature can be effectively prevented in this way
The oxidation of lower material.
The covering shape of the optothermal material is as shown in Fig. 2, for circular ring shape, and 4 be optothermal material in figure.
The thickness of optothermal material can be 100 microns hereinafter, further, 50 microns hereinafter, further, 1 micron with
Under, further, 500 nanometers or less and be not less than 1 nanometer.
Fig. 4 is the optical-fiber laser therapeutic device using this kind of laser probe, and described device includes endoscope 6, operation optical fiber
8, the laser probe, service aisle 7 is provided in the endoscope, and the operation optical fiber 8 is arranged in the service aisle 7
Interior, the laser probe can removably be connected with operation optical fiber 8, and the operation optical fiber 8 can move in service aisle 7
It is dynamic, sheath of the laser probe with covering service aisle 7.
The laser probe is connected through a screw thread connection with operation optical fiber 8.
7 edge of service aisle protrudes endoscope tip plane certain length, and service aisle bordered profiles circularize recess,
Fixation for the sheath.
Operation optical fiber 8 can be axially moveable in the service aisle 7 of endoscope 6, and 7 front end of service aisle is provided with and hand
The bayonet of art optical fiber cooperation, the bayonet include the elastic brake lining for closing bayonet, and bayonet outer is provided with opening for control brake lining
It closes, opens brake lining, the operation optical fiber can stretch out bayonet, connect with the cutter head, after treatment end, to the cutter head and institute
It states sheath to be cleaned, releases the connection of the cutter head and optical fiber of performing the operation, the operation optical fiber is withdrawn into bayonet, brake lining appliance for releasing single
It returns, closes bayonet, then release being fixedly connected for the sheath and service aisle, in this way, after primary operation, it only need to be to endoscope
Disinfection is purged outside 6, without carrying out cleaning and sterilizing to endoscopic working channel 7.
The shape of the brake lining can according to need setting, can be two semicircle brake linings, or multiple triangles
Blade.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (10)
1. a kind of replaceable laser probe of end with optothermal material, which is characterized in that the laser probe includes light-coming out optical fiber,
Optothermal material, the face of the optothermal material covering fiber end face 5%~60% are formed in the distal end faces of the light-coming out optical fiber
Product, the laser probe are removably connect with operation optical fiber.
2. laser probe according to claim 1, which is characterized in that the covering shape of the optothermal material is round, circle
One of ring, spot distribution, threadiness, radial or combinations thereof.
3. laser probe according to claim 1, which is characterized in that the optothermal material passes through coating, vapor deposition, magnetic
Control sputtering is deposited, the surface that any one method is formed in the optical fiber in welding.
4. laser probe according to claim 1, which is characterized in that welding carries out under protective atmosphere, using by He gas
The atmosphere of body composition.
5. laser probe according to claim 1, which is characterized in that the optothermal material is nano material.
6. laser probe according to claim 1, which is characterized in that the optothermal material is metal optothermal material, Buddha's warrior attendant
One of stone or semiconductor material are a variety of.
7. a kind of optical-fiber laser therapeutic device that laser probe is replaceable, which is characterized in that described device includes endoscope, operation
Optical fiber, laser probe as claimed in any one of claims 1 to 6 are provided with service aisle, the operation light in the endoscope
Fibre is arranged in the service aisle, and the laser probe can removably be connected with operation optical fiber, the operation optical fiber energy
It is enough to be moved in service aisle, sheath of the laser probe with covering service aisle.
8. optical-fiber laser therapeutic device according to claim 7, which is characterized in that it is attached that described device is included in optic fibre end
The temperature sensor being closely arranged, is monitored temperature.
9. optical-fiber laser therapeutic device according to claim 7, which is characterized in that described device includes cooling and cleaning is logical
Road, for being cleaned liquid injection to target site and being cooled down to target site.
10. optical-fiber laser therapeutic device according to claim 7, which is characterized in that the laser probe is with optical fiber of performing the operation
It is connected through a screw thread or is connected together.
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CN1049977A (en) * | 1989-09-08 | 1991-03-20 | 外科雷射科技日本公司 | Laser irradiating device |
CN2386783Y (en) * | 1999-07-08 | 2000-07-12 | 韩新峰 | Optical needle knife |
CN1883412A (en) * | 2005-06-21 | 2006-12-27 | 爱科凯能科技(北京)有限公司 | Laser medical equipment |
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CN101194857A (en) * | 2007-12-28 | 2008-06-11 | 马君显 | Laser lancet |
CN201350091Y (en) * | 2009-02-12 | 2009-11-25 | 湖北大汉科技有限公司 | Laser scalpel with replaceable optical fiber needle |
CN107157578A (en) * | 2017-07-03 | 2017-09-15 | 沈阳雷卓激光医疗器械有限公司 | Compatible disposable optical-fibre needle cuts laser handle arrangement |
CN107412957A (en) * | 2017-07-12 | 2017-12-01 | 华东师范大学 | A kind of photo-thermal therapy probe based on photo-thermal nano material |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1045695A (en) * | 1989-02-15 | 1990-10-03 | 外科雷射科技日本公司 | Generating laser |
CN1049612A (en) * | 1989-08-24 | 1991-03-06 | 外科镭射科技日本公司 | Laser light irradiation apparatus |
CN1049977A (en) * | 1989-09-08 | 1991-03-20 | 外科雷射科技日本公司 | Laser irradiating device |
CN2386783Y (en) * | 1999-07-08 | 2000-07-12 | 韩新峰 | Optical needle knife |
CN101076294A (en) * | 2003-03-18 | 2007-11-21 | 塞拉莫普泰克工业公司 | System and device for oral treatment |
CN1883412A (en) * | 2005-06-21 | 2006-12-27 | 爱科凯能科技(北京)有限公司 | Laser medical equipment |
CN101194857A (en) * | 2007-12-28 | 2008-06-11 | 马君显 | Laser lancet |
CN201350091Y (en) * | 2009-02-12 | 2009-11-25 | 湖北大汉科技有限公司 | Laser scalpel with replaceable optical fiber needle |
CN107157578A (en) * | 2017-07-03 | 2017-09-15 | 沈阳雷卓激光医疗器械有限公司 | Compatible disposable optical-fibre needle cuts laser handle arrangement |
CN107412957A (en) * | 2017-07-12 | 2017-12-01 | 华东师范大学 | A kind of photo-thermal therapy probe based on photo-thermal nano material |
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