CN109529112A - A kind of antibacterial functions osseous tissue renovating material and preparation method thereof - Google Patents
A kind of antibacterial functions osseous tissue renovating material and preparation method thereof Download PDFInfo
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- CN109529112A CN109529112A CN201910029406.5A CN201910029406A CN109529112A CN 109529112 A CN109529112 A CN 109529112A CN 201910029406 A CN201910029406 A CN 201910029406A CN 109529112 A CN109529112 A CN 109529112A
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- hydroxyapatite
- dopamine
- antibacterial functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Transplantation (AREA)
- Epidemiology (AREA)
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- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention discloses a kind of antibacterial functions osseous tissue renovating materials and preparation method thereof, so that hydroxyapatite is dispersed in buffer, the Dopamine hydrochloride of suitable dose is added in buffer, is stirred at room temperature 24 hours.It is centrifuged repeatedly, washs for several times, freeze-drying obtains the hydroxyapatite modified with poly-dopamine surface.Aqueous solution is placed it in, the silver nitrate of suitable dose is added, stirs at room temperature.It is centrifuged repeatedly, washs for several times, be freeze-dried to get hydroxyapatite-nano silver hybrid material.Poly-dopamine layer is coated in hydroxyapatite surface, is realized modified to hydroxyapatite surface.Then, using the reduction of dopamine point, make Nano silver deposition in hydroxyapatite surface, obtain the bone renovating material with antibacterial functions, which has good antibacterial property energy and good biocompatibility.
Description
Technical field
The present invention relates to hybrid material preparation technical field, specially a kind of antibacterial functions osseous tissue renovating material and its system
Preparation Method.
Background technique
Hydroxyapatite is a kind of osseous tissue renovating material, has good bioactivity and biocompatibility.But bone
It would generally cause serious bacterium, fungal infection after transplanting, the patient number dead because of organ transplant induction infection is huge every year
Greatly.It is bad come infection prevention effect by way of injection, oral drugs, because drug can enter circulation after entering human body quickly
System keeps drug concentration at organ transplant low.More seriously, drug can enter other organs with blood, cause to it
Toxic side effect.Then, it would be desirable to prevent to infect with a kind of more targeted administration mode.It says, infects in cell level
The reason of be: bacterial adhesion subsequently forms biomembrane at transplant organ, then induce infection.From this mechanism, we
It can adopt by some way, so that antibacterials come out from transplant organ surface controllable sustained-release.Not only make transplant organ in this way
The drug concentration at place improves, and also reduces the toxic side effect to other organs.
Domestic and international many seminars use this thinking, and the good bone renovating material of anti-microbial property has been made.Han Zhichao project
The method that group is surely changed with PVP is prepared dispersed nano Argent grain, is then added into spinning solution, prepared using electrostatic spinning
The antibacterial film of loading nano silvery is gone out.They have done the test of more system to the material anti-microbial property, cytotoxicity, it was demonstrated that
There are good antibacterial property energy, and toxicity very little under low dose in nano silver, Sahni G et al. passes through thermal decomposition method preparation
Hydroxyapatite/argentum nano composite material, has been also demonstrated that, in the case where silver concentration is very low, this composite material has very
Good bactericidal effect.So far, the equally distributed nano silver on hydroxyapatite can be prepared there are many method.So
And most methods are complex for operation step tediously long, reaction condition is more demanding, and reaction reagent used is more toxic.Then, one
Kind reaction step is few, and preparation method easy to operate is urgently developed.
2007, Haeshin Lee had found that the Mussels in ocean can almost be attached on the surface of any material, passed through
For analysis scallop in the substance for sticking interface secretion, they have found these substances rich in dopamine.Then, they are dopamine and certain
A little metals, organic matter combined by distinct methods, it was demonstrated that its brilliance sticks modification performance, and it is further proposed that with other materials
Expect it is compound after dopamine can be used as the concept of secondary response platform.This ingredient is simple, and reaction is mild, applied widely
Surface modifying species after delivering herein, start to be widely used.Zhang Liqun seminar makes more under aqueous basic conditions
In silica surface autohemagglutination occurs for bar amine, then instills silver ammino solution, using the reduction of diphenylol adjacent in poly-dopamine,
Nano silver has been plated on improved silica by success.Chien C Y et al. is modified by hydroxyapatite surface with dopamine, then
Modified hydroxyapatite is plated in titanium sheet, using its adjacent diphenylol in conjunction with RGD, promotes osteoblast and Bone Defect Repari material
The adherency of material.Current preparation method is complicated for operation, and antibacterial effect is poor.
Summary of the invention
It is above-mentioned to solve the purpose of the present invention is to provide a kind of antibacterial functions osseous tissue renovating material and preparation method thereof
The problem of being proposed in background technique.
To achieve the above object, the invention provides the following technical scheme: a kind of antibacterial functions osseous tissue renovating material, described
Repair materials, then in hydroxyapatite surface silver nanoparticles loaded, obtain hydroxyapatite-silver using hydroxyapatite as core
Hybrid material.
Preferably, a kind of preparation method of antibacterial functions osseous tissue renovating material, comprising the following steps:
A, hydroxyapatite is dispersed in water, and be slowly stirred, and adjust solution ph as alkalinity；
B, appropriate dopamine is added in the hydroxyapatite dispersion of step A configuration, due to dopamine auto polymerization, in hydroxyl
Apatite surface forms poly-dopamine layer；Separation, recycling solid product, the i.e. hydroxyapatite of acquisition poly-dopamine cladding；
C, the hydroxyapatite that poly-dopamine coats is dispersed in water, suitable silver nitrate is added, reacted；
D, separation, recycling solid matter are to get the osseous tissue renovating material with antibacterial functions: hydroxyapatite-silver hydridization material
Material.
Compared with prior art, the beneficial effects of the present invention are: in the present invention, poly- DOPA is coated in hydroxyapatite surface
Amine layer is realized modified to hydroxyapatite surface.Then, using the reduction of dopamine point, make Nano silver deposition in hydroxyl
Apatite surface obtains the bone renovating material with antibacterial functions, which has good antibacterial property energy and good biology
Compatibility.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
The invention provides the following technical scheme: a kind of antibacterial functions osseous tissue renovating material, the repair materials are with hydroxyl
Apatite is core, then in hydroxyapatite surface silver nanoparticles loaded, obtains hydroxyapatite-silver hybrid material.
In the present invention, a kind of preparation method of antibacterial functions osseous tissue renovating material, preparation method the following steps are included:
A, hydroxyapatite is dispersed in water, and be slowly stirred, and adjust solution ph as alkalinity；
B, appropriate dopamine is added in the hydroxyapatite dispersion of step A configuration, due to dopamine auto polymerization, in hydroxyl
Apatite surface forms poly-dopamine layer；Separation, recycling solid product, the i.e. hydroxyapatite of acquisition poly-dopamine cladding；
C, the hydroxyapatite that poly-dopamine coats is dispersed in water, suitable silver nitrate is added, reacted；
D, separation, recycling solid matter are to get the osseous tissue renovating material with antibacterial functions: hydroxyapatite-silver hydridization material
Material.
Hydroxyapatite is set to be dispersed in buffer.The Dopamine hydrochloride of suitable dose is added in buffer, in room temperature
Lower stirring 24 hours.It is centrifuged repeatedly, washs for several times, freeze-drying obtains the hydroxyapatite modified with poly-dopamine surface.It will
It is placed in aqueous solution, and the silver nitrate of suitable dose is added, stirs at room temperature.Be centrifuged repeatedly, wash for several times, freeze-drying to get
Hydroxyapatite-nano silver hybrid material.
In conclusion coating poly-dopamine layer in the present invention in hydroxyapatite surface, realizing to hydroxyapatite surface
It is modified.Then, using the reduction of dopamine point, make Nano silver deposition in hydroxyapatite surface, obtain with antibacterial function
The bone renovating material of energy, the material have good antibacterial property energy and good biocompatibility.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (2)
1. a kind of antibacterial functions osseous tissue renovating material, it is characterised in that: the repair materials are using hydroxyapatite as core, then
In hydroxyapatite surface silver nanoparticles loaded, hydroxyapatite-silver hybrid material is obtained.
2. realizing a kind of preparation method of antibacterial functions osseous tissue renovating material described in claim 1, it is characterised in that: preparation
Method the following steps are included:
A, hydroxyapatite is dispersed in water, and be slowly stirred, and adjust solution ph as alkalinity；
B, appropriate dopamine is added in the hydroxyapatite dispersion of step A configuration, due to dopamine auto polymerization, in hydroxyl
Apatite surface forms poly-dopamine layer；Separation, recycling solid product, the i.e. hydroxyapatite of acquisition poly-dopamine cladding；
C, the hydroxyapatite that poly-dopamine coats is dispersed in water, suitable silver nitrate is added, reacted；
D, separation, recycling solid matter are to get the osseous tissue renovating material with antibacterial functions: hydroxyapatite-silver hydridization material
Material.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755691A (en) * | 2019-11-29 | 2020-02-07 | 华南理工大学 | Preparation method of antibacterial bracket for bone repair |
| CN110898258A (en) * | 2019-12-10 | 2020-03-24 | 河南亚都实业有限公司 | Antibacterial collagen-based bone repair material |
| CN113198044A (en) * | 2021-04-08 | 2021-08-03 | 华南理工大学 | HHC 36-loaded polydopamine-functionalized hydroxyapatite composite material and preparation method and application thereof |
| CN114432490A (en) * | 2021-11-10 | 2022-05-06 | 北京大学口腔医学院 | 3D printing material and preparation method and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755691A (en) * | 2019-11-29 | 2020-02-07 | 华南理工大学 | Preparation method of antibacterial bracket for bone repair |
| CN110898258A (en) * | 2019-12-10 | 2020-03-24 | 河南亚都实业有限公司 | Antibacterial collagen-based bone repair material |
| CN113198044A (en) * | 2021-04-08 | 2021-08-03 | 华南理工大学 | HHC 36-loaded polydopamine-functionalized hydroxyapatite composite material and preparation method and application thereof |
| CN114432490A (en) * | 2021-11-10 | 2022-05-06 | 北京大学口腔医学院 | 3D printing material and preparation method and application thereof |
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