CN109490248A - A kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation - Google Patents
A kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation Download PDFInfo
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 40
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- 238000005259 measurement Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
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- 230000008520 organization Effects 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
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- G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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Abstract
The invention discloses a kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation, the detection system includes light source group, phase-modulator group, reflection microscope group and analysis of blood sugar unit；Light source group includes first light source and second light source, and phase-modulator group includes first phase modulator and second phase modulator, and the phase modulation of first phase modulator and the phase modulation of second phase modulator differ 180 °；Reflecting microscope group includes total reflection mirror and half-reflecting mirror；First light source, first phase modulator and total reflection mirror are set gradually, and second light source, second phase modulator and half-reflecting mirror are set gradually；First incident light and the second incident light merge into a detection light, and detection light passes through sample to be tested and inputs analysis of blood sugar unit；The present invention solves the problems, such as that blood glucose spectral detection system cost input of the existing technology is big, detection method is complicated, the absorption peak of detection difficult and non-absorbing wave band causes testing result to deviate systematic influence.
Description
Technical field
The invention belongs to technical field of spectral detection, and in particular to a kind of blood glucose spectral detection based on modulation reverse phase cancellation
System and detection method.
Background technique
Diabetes are a kind of metabolic diseases characterized by hyperglycemia, will lead to various tissues, especially eye, kidney, the heart
Dirty, blood vessel, the chronic lesion of nerve, dysfunction.Therefore, in diabetic's body blood glucose value height controlling for diabetes
More and the progression of the disease situation of observation diabetes has directive significance.However, most of existing blood sugar test equipment is that have
Wound, diabetic needs often to puncture epidermis and acquire venous blood, to measure blood glucose value.For a long time in this way, not only making sugar
Urine patient has infection risk because frequently taking a blood sample, and patient's long term purchase blood testing batten is also a no small expense.Institute
A painless, safely and conveniently system for detecting blood sugar is needed with, diabetic.
Spectral technique is common a kind of technology in Woundless blood sugar measurement.So-called spectral technique is exactly to pass through to measure a kind of object
Interactive relationship between matter and various different wave length light waves, to measure the concentration of this kind of substance.Glucose is near infrared light (600nm-
Spectral signature 2500nm) and under mid-infrared light (2500nm-16000nm) irradiation is the most obvious.The advantage of near-infrared is its group
Knit penetration power be better than in it is infrared, the disadvantage is that glucose is infrared strong without in the spectrum specificity of near-infrared.In infrared be known as
" fingerprint " in spectrum, high specificity, but it is infrared high to emitter requirement due in, and human body group cannot be penetrated substantially
Knit, thus in it is infrared at present Woundless blood sugar monitoring field be not in progress excessively.Near-infrared is then Woundless blood sugar monitoring neck at present
Most one of technology paths is explored in domain, how to be overcome the problems, such as near infrared spectrum specificity and signal strength, is to grind from now on
The emphasis studied carefully.
The prior art has the following problems:
(1) structure is complicated for existing system for detecting blood sugar, and cost input is high, and detection method is complicated, detection difficult；
(2) organization of human body is complicated, and there are a variety of non-detection factors, and detection system is had an impact.
Summary of the invention
The purpose of the present invention is to propose to a kind of blood glucose spectral detection systems and detection method based on modulation reverse phase cancellation, use
In solving, blood glucose spectral detection system cost input of the existing technology is big, detection method is complicated, detection difficult and non-suction
The problem of receiving the absorption peak of wave band causes testing result to deviate systematic influence.
The technical solution of the present invention is as follows: a kind of blood glucose spectral detection system based on modulation reverse phase cancellation, including successively set
Light source group, phase-modulator group, reflection microscope group and the analysis of blood sugar unit set；
Light source group includes first light source disposed in parallel and second light source, the launch wavelength of second light source and and first light source
Launch wavelength it is neighbouring, phase-modulator group includes first phase modulator and second phase modulator, first phase modulator
Phase modulation and second phase modulator phase modulation differ 180 °；Reflection microscope group include total reflection mirror disposed in parallel and
Half-reflecting mirror；
The output end of first light source is provided with first phase modulator, and the output end of first phase modulator, which is provided with, to be all-trans
Mirror is penetrated, the output end of second light source is provided with second phase modulator, and the output end of second phase modulator is provided with half reflection
Mirror；
By first light source emit and by total reflection mirror reflection the first incident light with by second light source transmitting and through more than half
Second incident light of reflecting mirror reflection merges into a detection light, and detection light passes through sample to be tested and inputs analysis of blood sugar unit.
Further, analysis of blood sugar unit includes sequentially connected photodetector, signal processing module and host computer,
Detection light inputs photodetector.
Further, the centre of first light source and first phase modulator is provided with sequentially connected first optical fiber collimator
It is connect by optical fiber with the input terminal of first phase modulator with the output end of the first fiber coupler, the first fiber coupler；
The centre of second light source and second phase modulator is provided with sequentially connected second optical fiber collimator and the second light
The output end of fine coupler, the second fiber coupler is connect by optical fiber with the input terminal of second phase modulator；
The output end of first phase modulator is provided with third optical fiber collimator, the output end setting of third optical fiber collimator
There is total reflection mirror；The output end of second phase modulator is provided with the 4th optical fiber collimator, the output end of the 4th optical fiber collimator
It is provided with half-reflecting mirror.
Further, the input terminal of photodetector is provided with the 5th optical fiber collimator, the output of the 5th optical fiber collimator
End is connect by optical fiber with photodetector.
Further, optical fiber is single mode optical fiber.
Further, the model SMA905 of fiber coupler, first light source and second light source are HSE1200-L504
Type LED.
A kind of detection method based on blood glucose spectral detection system, includes the following steps:
S1: emit corresponding first incident light and the second incident light using first light source and second light source；
The wavelength of the wavelength of first incident light and the second incident light is neighbouring, and wavelength difference range is 50-100nm；
S2: the phase of corresponding first incident light and second are entered using first phase modulator and second phase modulator
The phase for penetrating light is modulated, and obtains 180 ° of phase phase difference of the first modulation incident light and the second modulation incident light；
S3: the first modulation incident light is reflected using total reflection mirror, using half-reflecting mirror to the second modulation incident light
It is reflected, and the first modulation incident light after reflection is made to pass through half-reflecting mirror, be overlapped with the second modulation incident light after reflection,
Generate a detection light；
S4: sample to be tested is passed through using detection light, the detection of sample to be tested is carried out, obtains spectrum change light；
S5: spectrum change light is converted into corresponding electric signal using the photodetector of analysis of blood sugar unit；
S6: being carried out the processing of electric signal using signal processing module, and be transmitted to host computer and analyzed, and realizes blood glucose light
Spectrum detection.
Further, further include step S1.5 between step S1 and step S2: receiving first using the first optical fiber collimator
Incident light, and first phase modulator is transmitted to by the first fiber coupler；
The second incident light is received using the second optical fiber collimator, and second phase tune is transmitted to by the second fiber coupler
Device processed.
Further, further include step S2.5 between step S2 and step S3: using third optical fiber collimator output first
Modulate incident light；Use the 4th optical fiber collimator output the second modulation incident light.
Further, further include step S4.5 between step S4 and step S5: receiving spectrum using the 5th optical fiber collimator
Change light, and is transmitted to photodetector.
This programme has the beneficial effect that
(1) a kind of blood glucose spectral detection system based on modulation reverse phase cancellation that this programme provides, using test near-infrared
Light passes through the variation of spectral information before and after sample to be tested, measures blood glucose value, and this system structure is simple, the equipment cost investment of use
It is low；
(2) principle for using 180 ° of phase cancellations, completely eliminates influence of the absorption peak to system of non-absorbing wave band, improves
The accuracy of system；
(3) incident light is merged using the total reflection mirror and half-reflecting mirror of reflection microscope group, realizes the inspection of sample to be tested
It surveys, detection method is simple, improves practicability.
Detailed description of the invention
Fig. 1 show one structural schematic diagram of blood glucose spectral detection system embodiment based on modulation reverse phase cancellation；
Fig. 2 show two structural schematic diagram of blood glucose spectral detection system embodiment based on modulation reverse phase cancellation；
Fig. 3 show analysis of blood sugar cellular construction block diagram；
Fig. 4 show photo-detector circuit schematic diagram；
Fig. 5 show signal processing circuit schematic diagram；
Fig. 6 show light source driving circuit schematic diagram；
Fig. 7 show detection method flow chart；
Fig. 8 show phase-contrast figure；
Fig. 9 show blood glucose and absorbs light intensity-wavelength change figure.
Wherein, 11, first light source；12, second light source；21, first phase modulator；22, second phase modulator；31,
Total reflection mirror；32, half-reflecting mirror；4, photodetector；5, sample to be tested；61, the first incident light；62, the second incident light；63,
Detection light；71, the first optical fiber collimator；72, the second optical fiber collimator；73, third optical fiber collimator；74, the 4th fiber optic collimator
Device；75, the 5th optical fiber collimator；81, the first fiber coupler；82, the second fiber coupler.
Specific embodiment
Carry out detailed description of the present invention illustrative embodiments with reference to the drawings.It should be appreciated that shown in attached drawing and
The embodiment of description is only exemplary, it is intended that is illustrated the principle and spirit of the invention, and is not limited model of the invention
It encloses.
Embodiment one:
The embodiment of the invention provides a kind of blood glucose spectral detection systems based on modulation reverse phase cancellation, as shown in Figure 1, packet
Include the light source group set gradually, phase-modulator group, reflection microscope group and analysis of blood sugar unit as shown in Figure 3；Using test
Near infrared light passes through the variation of 5 front and back spectral information of sample to be tested, measures blood glucose value, this system structure is simple, the equipment of use
Cost input is low；
Light source group includes first light source 11 disposed in parallel and second light source 12, the launch wavelength of second light source 12 and with
The launch wavelength of one light source 11 is neighbouring, and phase-modulator group includes first phase modulator 21 and second phase modulator 22, and
The phase modulation of one phase-modulator 21 and the phase modulation of second phase modulator 22 differ 180 °；As shown in figure 8, using
The principle of 180 ° of phase cancellations completely eliminates influence of the absorption peak to system of non-absorbing wave band, improves the accuracy of system,
Wherein it is as shown in Figure 9 with wavelength change to absorb light intensity for blood glucose；Reflecting microscope group includes total reflection mirror 31 disposed in parallel and half reflection
Mirror 32；
The output end of first light source 11 is provided with first phase modulator 21, the output end setting of first phase modulator 21
There is total reflection mirror 31, the output end of second light source 12 is provided with second phase modulator 22, the output of second phase modulator 22
End is provided with half-reflecting mirror 32；
The incidence angle and total reflection mirror 31 and photoelectricity that the output end and total reflection mirror 31 of first phase modulator 21 are formed are visited
It is identical to survey the angle of reflection that device 4 is formed；The incidence angle and be all-trans that the output end of second phase modulator 22 is formed with half-reflecting mirror 32
It is identical as the angle of reflection that photodetector 4 is formed to penetrate mirror 31；
Emitted by first light source 11 and is emitted by the first incident light 61 that total reflection mirror 31 reflects with by second light source 12
And a detection light 63 is merged by the second incident light 62 that half-reflecting mirror 32 reflects, detection light 63 passes through sample to be tested 5 simultaneously
Input analysis of blood sugar unit；Using reflection microscope group total reflection mirror 31 and half-reflecting mirror 32 incident light is merged, realize to
The detection of test sample sheet 5, detection method is simple, improves practicability；
In the present embodiment, analysis of blood sugar unit includes sequentially connected photodetector 4, signal processing module and upper
Machine, detection light 63 input photodetector 4；The circuit of photodetector 4 as shown in figure 4, signal processing module circuit such as Fig. 5
It is shown.
In the present embodiment, first light source 11 and second light source 12 are HSE 1200-L504 type LED；11 He of first light source
The driving circuit of second light source 12 is as shown in Figure 6.
A kind of detection method based on blood glucose spectral detection system, as shown in fig. 7, comprises following steps:
S1: emit corresponding first incident light and the second incident light using first light source and second light source；
The wavelength of the wavelength of first incident light and the second incident light is neighbouring, and wavelength difference range is 50-100nm；
S2: the phase of corresponding first incident light and second are entered using first phase modulator and second phase modulator
The phase for penetrating light is modulated, and obtains 180 ° of phase phase difference of the first modulation incident light and the second modulation incident light；
S3: the first modulation incident light is reflected using total reflection mirror, using half-reflecting mirror to the second modulation incident light
It is reflected, and the first modulation incident light after reflection is made to pass through half-reflecting mirror, be overlapped with the second modulation incident light after reflection,
Generate a detection light；
S4: sample to be tested is passed through using detection light, the detection of sample to be tested is carried out, obtains spectrum change light；
S5: spectrum change light is converted into corresponding electric signal using the photodetector of analysis of blood sugar unit；
S6: being carried out the processing of electric signal using signal processing module, and be transmitted to host computer and analyzed, and realizes blood glucose light
Spectrum detection.
Embodiment two:
The embodiment of the invention provides a kind of blood glucose spectral detection systems based on modulation reverse phase cancellation, as shown in Fig. 2, packet
Include the light source group set gradually, phase-modulator group, reflection microscope group and analysis of blood sugar unit as shown in Figure 3；Using test
Near infrared light passes through the variation of 5 front and back spectral information of sample to be tested, measures blood glucose value, this system structure is simple, the equipment of use
Cost input is low；
Light source group includes first light source 11 disposed in parallel and second light source 12, the launch wavelength of second light source 12 and with
The launch wavelength of one light source 11 is neighbouring, and phase-modulator group includes first phase modulator 21 and second phase modulator 22, and
The phase modulation of one phase-modulator 21 and the phase modulation of second phase modulator 22 differ 180 °；As shown in figure 8, using
The principle of 180 ° of phase cancellations completely eliminates influence of the absorption peak to system of non-absorbing wave band, improves the accuracy of system,
Wherein it is as shown in Figure 9 with wavelength change to absorb light intensity for blood glucose；Reflecting microscope group includes total reflection mirror 31 disposed in parallel and half reflection
Mirror 32；
The output end of first light source 11 is provided with first phase modulator 21, the output end setting of first phase modulator 21
There is total reflection mirror 31, the output end of second light source 12 is provided with second phase modulator 22, the output of second phase modulator 22
End is provided with half-reflecting mirror 32；
Emitted by first light source 11 and is emitted by the first incident light 61 that total reflection mirror 31 reflects with by second light source 12
And a detection light 63 is merged by the second incident light 62 that half-reflecting mirror 32 reflects, detection light 63 passes through sample to be tested 5 simultaneously
Input analysis of blood sugar unit.
In the present embodiment, analysis of blood sugar unit includes sequentially connected photodetector 4, signal processing module and upper
Machine, detection light 63 input photodetector 4；The circuit of photodetector 4 as shown in figure 4, signal processing module circuit such as Fig. 5
It is shown.
In the present embodiment, the centre of first light source 11 and first phase modulator 21 is provided with sequentially connected first optical fiber
The output end of collimator 71 and the first fiber coupler 81, the first fiber coupler 81 passes through optical fiber and first phase modulator 21
Input terminal connection, improve the utilization rate of the first incident light 61；
The centre of second light source 12 and second phase modulator 22 is provided with sequentially connected second optical fiber collimator, 72 He
The output end of second fiber coupler 82, the second fiber coupler 82 is connected by the input terminal of optical fiber and second phase modulator 22
It connects, improves the utilization rate of the second incident light 62；The driving circuit of first light source 11 and second light source 12 is as shown in Figure 6；
The output end of first phase modulator 21 is provided with third optical fiber collimator 73, the output of third optical fiber collimator 73
End is provided with total reflection mirror 31；The output end of second phase modulator 22 is provided with the 4th optical fiber collimator 74, and the 4th optical fiber is quasi-
The output end of straight device 74 is provided with half-reflecting mirror 32.
Further, the input terminal of photodetector 4 is provided with the 5th optical fiber collimator 75, the 5th optical fiber collimator 75
Output end is connect by optical fiber with photodetector 4.
In the present embodiment, optical fiber is single mode optical fiber.
In the present embodiment, the model SMA905 of fiber coupler, first light source 11 and second light source 12 are HSE
1200-L504 type LED.
A kind of detection method based on blood glucose spectral detection system, as shown in fig. 7, comprises following steps:
S1: emit corresponding first incident light and the second incident light using first light source and second light source；
The wavelength of the wavelength of first incident light and the second incident light is neighbouring, and wavelength difference range is 50-100nm；
S1.5: the first incident light is received using the first optical fiber collimator, and is transmitted to first by the first fiber coupler
Phase-modulator；
The second incident light is received using the second optical fiber collimator, and second phase tune is transmitted to by the second fiber coupler
Device processed；
S2: the phase of corresponding first incident light and second are entered using first phase modulator and second phase modulator
The phase for penetrating light is modulated, and obtains 180 ° of phase phase difference of the first modulation incident light and the second modulation incident light；
S2.5: third optical fiber collimator output the first modulation incident light is used；Use the 4th optical fiber collimator output second
Modulate incident light；
S3: the first modulation incident light is reflected using total reflection mirror, using half-reflecting mirror to the second modulation incident light
It is reflected, and the first modulation incident light after reflection is made to pass through half-reflecting mirror, be overlapped with the second modulation incident light after reflection,
Generate a detection light；
S4: sample to be tested is passed through using detection light, the detection of sample to be tested is carried out, obtains spectrum change light；
S4.5: spectrum change light is received using the 5th optical fiber collimator, and is transmitted to photodetector；
S5: spectrum change light is converted into corresponding electric signal using the photodetector of analysis of blood sugar unit；
S6: being carried out the processing of electric signal using signal processing module, and be transmitted to host computer and analyzed, and realizes blood glucose light
Spectrum detection.
A kind of blood glucose spectral detection system and detection method based on modulation reverse phase cancellation provided by the invention, solves existing
Have existing for technology that blood glucose spectral detection system cost input is big, detection method is complicated, detection difficult and non-absorbing wave band
The problem of absorption peak causes testing result to deviate systematic influence.
Those of ordinary skill in the art will understand that the embodiments described herein, which is to help reader, understands this hair
Bright principle, it should be understood that protection scope of the present invention is not limited to such specific embodiments and embodiments.This field
Those of ordinary skill disclosed the technical disclosures can make according to the present invention and various not depart from the other each of essence of the invention
The specific variations and combinations of kind, these variations and combinations are still within the scope of the present invention.
Claims (10)
1. it is a kind of based on modulation reverse phase cancellation blood glucose spectral detection system, which is characterized in that including set gradually light source group,
Phase-modulator group, reflection microscope group and analysis of blood sugar unit；
The light source group includes first light source disposed in parallel (11) and second light source (12), the transmitting of the second light source (12)
Wavelength and neighbouring with the launch wavelength of first light source (11), the phase-modulator group includes first phase modulator (21) and
Two phase modulator (22), the phase modulation of the first phase modulator (21) and the modulation phase of second phase modulator (22)
180 ° of phase difference；The reflection microscope group includes total reflection mirror disposed in parallel (31) and half-reflecting mirror (32)；
The output end of the first light source (11) is provided with first phase modulator (21), the first phase modulator (21)
Output end is provided with total reflection mirror (31), and the output end of the second light source (12) is provided with second phase modulator (22), institute
The output end for stating second phase modulator (22) is provided with half-reflecting mirror (32)；
Emitted by first light source (11) and passed through first incident light (61) of total reflection mirror (31) reflection and by second light source (12)
Emit and the second incident light (62) by half-reflecting mirror (32) reflection merges into a detection light (63), the detection light (63)
Across sample to be tested (5) and input analysis of blood sugar unit.
2. the blood glucose spectral detection system as described in claim 1 based on modulation reverse phase cancellation, which is characterized in that the blood glucose
Analytical unit includes sequentially connected photodetector (4), signal processing module and host computer, detection light (63) input
Photodetector (4).
3. the blood glucose spectral detection system as claimed in claim 2 based on modulation reverse phase cancellation, which is characterized in that described first
The centre of light source (11) and first phase modulator (21) is provided with sequentially connected first optical fiber collimator (71) and the first light
Fine coupler (81), the output end of first fiber coupler (81) pass through the input of optical fiber and first phase modulator (21)
End connection；
The centre of the second light source (12) and second phase modulator (22) is provided with sequentially connected second optical fiber collimator
(72) it is modulated with the second fiber coupler (82), the output end of second fiber coupler (82) by optical fiber and second phase
The input terminal of device (22) connects；
The output end of the first phase modulator (21) is provided with third optical fiber collimator (73), the third optical fiber collimator
(73) output end is provided with total reflection mirror (31)；The output end of the second phase modulator (22) is provided with the 4th optical fiber standard
Straight device (74), the output end of the 4th optical fiber collimator (74) are provided with half-reflecting mirror (32).
4. the blood glucose spectral detection system as claimed in claim 3 based on modulation reverse phase cancellation, which is characterized in that the photoelectricity
The input terminal of detector (4) is provided with the 5th optical fiber collimator (75), and the output end of the 5th optical fiber collimator (75) passes through
Optical fiber is connect with photodetector (4).
5. the blood glucose spectral detection system as claimed in claim 4 based on modulation reverse phase cancellation, which is characterized in that the optical fiber
For single mode optical fiber.
6. the blood glucose spectral detection system as claimed in claim 5 based on modulation reverse phase cancellation, which is characterized in that the optical fiber
The model SMA905 of coupler, the first light source (11) and second light source (12) are HSE 1200-L504 type LED.
7. a kind of blood glucose spectral method of detection based on modulation reverse phase cancellation, which comprises the steps of:
S1: emit corresponding first incident light and the second incident light using first light source and second light source；
The wavelength of first incident light and the wavelength of the second incident light are neighbouring, and wavelength difference range is 50-100nm；
S2: using first phase modulator and second phase modulator to the phase and the second incident light of corresponding first incident light
Phase be modulated, obtain 180 ° of phase phase difference first modulation incident light and second modulation incident light；
S3: reflecting the first modulation incident light using total reflection mirror, is carried out using half-reflecting mirror to the second modulation incident light
Reflection, and the first modulation incident light after reflection is made to pass through half-reflecting mirror, it is overlapped, generates with the second modulation incident light after reflection
One detection light；
S4: sample to be tested is passed through using detection light, the detection of sample to be tested is carried out, obtains spectrum change light；
S5: spectrum change light is converted into corresponding electric signal using the photodetector of analysis of blood sugar unit；
S6: being carried out the processing of electric signal using signal processing module, and be transmitted to host computer and analyzed, and realizes the inspection of blood glucose spectrum
It surveys.
8. detection method as claimed in claim 7, which is characterized in that further include step between the step S1 and step S2
S1.5: the first incident light is received using the first optical fiber collimator, and first phase modulation is transmitted to by the first fiber coupler
Device；
The second incident light is received using the second optical fiber collimator, and second phase modulation is transmitted to by the second fiber coupler
Device.
9. detection method as claimed in claim 7, which is characterized in that further include step between the step S2 and step S3
S2.5: third optical fiber collimator output the first modulation incident light is used；It is incident using the second modulation of the 4th optical fiber collimator output
Light.
10. detection method as claimed in claim 7, which is characterized in that further include step between the step S4 and step S5
S4.5: spectrum change light is received using the 5th optical fiber collimator, and is transmitted to photodetector.
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