CN109431538A - A kind of gene tester and equipment applied to supersonic imaging apparatus - Google Patents
A kind of gene tester and equipment applied to supersonic imaging apparatus Download PDFInfo
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- CN109431538A CN109431538A CN201811411479.2A CN201811411479A CN109431538A CN 109431538 A CN109431538 A CN 109431538A CN 201811411479 A CN201811411479 A CN 201811411479A CN 109431538 A CN109431538 A CN 109431538A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4472—Wireless probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B8/56—Details of data transmission or power supply
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Abstract
The invention discloses a kind of gene testers and equipment applied to supersonic imaging apparatus, the function and application range of existing ultrasonic imaging method and equipment can be effectively enriched by using graphene sensor, the utilization efficiency of equipment is improved, provides a possibility that more for the detection of relevant medicine.
Description
Technical field
The present invention relates to a kind of gene testers and equipment applied to supersonic imaging apparatus, are based especially on graphene
The gene tester of sensor.
Background technique
The principle of conventional ultrasound imaging device is scanned by ultrasonic acoustic beam, using reflection ultrasonic signal (reflection
Ultrasound echo signal) information non-invasively obtain the laminogram or image relevant to blood flow of tissue, and use
In various treatment purposes, for example, the observation of the internal image of target object, detection of foreign matter etc., have in medical domain
Be widely applied.
And graphene (Graphene) is a kind of novel two-dimension nano materials, is presently found hardness highest, toughness
Strongest nano material.Because of its special nanostructure and excellent physical and chemical performance, graphene electronics, optics, magnetics,
The fields such as biomedical, catalysis, energy storage and sensor have a extensive future, and are acknowledged as " prospective material " and " leather of 21 century
Life property material ".Currently, graphene is applied in four big fields: sensor field, energy storage and novel display field, semiconductor field,
Field of biomedicine etc..
And graphene and ultrasonic imaging field have intersection, in the application study of current mainstream, graphene is mainly made
For contrast agent come using.However graphene is only used as contrast agent, too limits to as 21 century most revolutionary material,
And there is no the characteristics of playing graphene completely and advantage.
A kind of L-type PML/RAR alpha fusion gene detection kit and phase are proposed in patent document CN201210449468.X
The detection method answered, it provides a kind of easy to operate, sensitive, special, quickly and effectively detection kit, utilizes functionalization GO
As carrier and fluorescent quenching tool, the single stranded DNA of fluorescent marker is carried as probe, can quickly, accurately be detected a certain
Kind cell whether there is L-type PML/RAR alpha fusion gene, be acute promyelocytic leukemia (Acute Promyelocytic
Leukemia, APL) PML/RAR alpha fusion gene detection.However this kit and detection method, it is only applicable to external inspection
Survey, need to extract the biopsy sample of detected person, program is cumbersome, and inflexible, meanwhile, testing result be microscope or
The precision of the artificial detection of cell instrument, detection is not high enough.
Summary of the invention
The purpose of the present invention is overcoming above-mentioned the deficiencies in the prior art, a kind of structure novel is provided, is skillfully constructed application
In the gene tester of supersonic imaging apparatus, the function and application of existing supersonic imaging apparatus greatly can be enriched and extended
Scene, while promoting the precision and ease for use of genetic test.
The present invention is realized by scheme below:
A kind of gene tester applied to supersonic imaging apparatus, comprising the following steps: step 1: the ultrasonic imaging
It is provided with micro radio ultrasonic probe in equipment, graphene gene sensor is provided on the wireless ultrasound probe, it will be wireless
Ultrasonic probe is placed into subject's body；Step 2: being converted into the intracorporal environmental information of people by graphene gene sensor
Electric signal；Step 3: electric signal is amplified into hot-tempered processing；Step 4: by treated, electric signal carries out on the terminal device
Calculation processing obtains detection result.
Further, the graphene gene sensor is made of the DNA probe transistor based on graphene, the DNA
Probe includes the double-spiral structure of two complementary dna chains composition.
Further, the DNA probe is with target cell by being coupled, when detecting that characteristics of electrical conductivity changes
When, generation environment information electric signal.
Further, it is provided with information database in the terminal device, includes different electrical signals in the information database
Corresponding detection result, the environmental information electric signal that the terminal device is reported according to the DNA probe, in the information data
It is inquired in library, obtains final detection result.
Further, the wireless ultrasound probe is set by ZIGBEE agreement or bluetooth or the wifi connection terminal
It is standby.
Compared with prior art, the present invention the beneficial effect is that:
Firstly, graphene gene sensor has many advantages, such as that precision is high, small in size, low in energy consumption, by ultrasonic probe
Graphene gene sensor is set, the volume of ultrasonic probe can be reduced to greatest extent, and then what be can be convenient enters human body
In vivo, it is directly contacted with organ, then carries out genetic test.
Secondly, the method for traditional genetic test is all to need to carry out sample to me by detection agent or detection box
Extract, it is very inconvenient and inefficient for intracorporal various detections, and by the method for ultrasonic probe, can directly into
Enter vivo detection, different positions can be moved to according to the needs of doctor, and can provide by the calculating of equipment more quasi-
True result.
Finally, method and apparatus involved in the present invention, existing ultrasonic imaging method and equipment can be effectively enriched
Function and application range improves the utilization efficiency of equipment, provides a possibility that more for the detection of relevant medicine.
Detailed description of the invention
The structure chart of Fig. 1 supersonic imaging apparatus in the prior art.
Fig. 2 is the method work flow diagram of one embodiment of the invention.
Fig. 3 is the construction module schematic diagram of one embodiment of the invention.
Fig. 4 is the three-dimensional structure diagram of one embodiment of the invention.
The cross-sectional view of the position Fig. 5 embodiment of the present invention.
Specific embodiment
The following further describes the present invention with reference to the drawings.These attached drawings are simplified schematic diagram, only with the side of signal
Formula illustrates basic structure of the invention, therefore it only shows the composition relevant to the invention.
Fig. 1 shows the overall structure of the supersonic imaging apparatus based on graphene of the prior art.In traditional architectures, surpass
Acoustic imaging equipment include ultrasonic probe, image acquisition units, memory, image processing unit, display unit, input unit and
Control unit.Ultrasonic probe is received to the intracorporal region of interest emission ultrasound of subject (such as patient) from subject
The ultrasonic echo of internal area-of-interest reflection.Ultrasonic probe may include the spy for being disposed therein piezoelectric device in the form of an array
Head array, and it is emerging with sense of the real-time volume ultrasonic scanning mode to the target blood for including target site and guiding catheter insertion
Interesting region executes ultrasonic scan.Image acquisition units acquire the 3-D scanning number of target site and target blood in area-of-interest
According to, and the 3 d scan data of acquisition is saved in memory in the form of three-dimensional data matrix in ultrasonic beam space,
Middle memory is the mass storage of such as hard disk.Control unit is calculated according to the 3 d scan data of acquisition for leading
The centerline length of the target blood of pipe insertion.Image processing unit is configured to the centerline length according to calculating from positioned at mesh
The critical line at position is marked along target blood center line automatic marking path scale display unit at a predetermined interval, is configured to aobvious in real time
Show target site and the target blood center line for being marked with distance scale.
In the supersonic imaging apparatus of the prior art, graphene is important to be come as contrast agent using however graphene is made
For new century most revolutionary novel nano-material, only as contrast agent apparently without being fully used.And with people
Improvement of living standard, everybody recognizes and more urgent needs the prevention and control of disease there has also been more profound.And
Genetic test is also the means that the development disease that soon, still scientific circles widely have an optimistic view of is prevented in advance, for many diseases
For, have embodiment on gene, can be handled in advance before not disease hair by genetic test.This means have been got over
More to be received and be used by broad masses.
However in the prior art, the method for genetic test is carried out often by the mode of kit or analyzed in vitro
, that is, need subject to provide tested biopsy sample to detect, this method range that can be detected is limited to very much, together
When, this method is also to be detected by microscopic or the method for chemical equation, and the precision of detection is inadequate.Therefore,
The scope of application and accuracy of genetic test are promoted there is an urgent need for a kind of method.
Embodiment one:
Fig. 2 shows one kind；The flow diagram of gene tester applied to supersonic imaging apparatus, comprising:
Step 1: being provided with micro radio ultrasonic probe on the supersonic imaging apparatus, be arranged on the wireless ultrasound probe
There is graphene gene sensor, wireless ultrasound probe is placed into subject's body.
This micro radio ultrasonic probe of the invention, can be by directly acting on the epidermis of subject or by micro-
Invasive procedures are implanted into human body, carry out external or intracorporal genetic test, meanwhile, intracorporal detection can also act on different
Organ and position, therefore, compared to detection reagent or the mode of detection box, more flexibly, the scope of application is also wider.
Step 2: the intracorporal environmental information of people is converted by electric signal by graphene gene sensor.
Graphene is a kind of structure and the metastable novel nano-material of performance, there is good mechanical stretching and electronics
Attribute.Nano-sensor based on graphene has been obtained now to be widely applied.Pass through each graphene atom and induction
Environment is in contact, and the electrical properties of graphene can be changed by this contact.It therefore can be by this characteristic, by stone
The environmental information that black alkene sensor is contacted with induction environment is converted into electric signal and is transmitted.
Step 3: electric signal is amplified into hot-tempered processing.
For under normal circumstances, the detection environment of ultrasonic probe is generally all more complicated, in order to promoted detection precision and
Accuracy, can amplify and go hot-tempered processing by electric signal, and amplify and to go hot-tempered algorithm to have very big, the present invention to this not
Do specific restriction.
Step 4: by treated, electric signal carries out calculation processing on the terminal device, obtains detection result.
Ultrasonic probe by amplification go it is hot-tempered after electric signal by wireless communication agreement be sent to terminal device carry out it is further
Processing and judgement, finally obtain the result of detection.
Ultrasonic probe by amplification go it is hot-tempered after electric signal by wireless communication agreement be sent to terminal device carry out it is further
Processing and judgement, finally obtain the result of detection.
Preferably, the graphene gene sensor has and is made of the DNA probe transistor based on graphene, described
DNA probe includes the double-spiral structure of two complementary dna chains composition.The principle that many diseases can detected from gene is just
It is that the gene of disease can be embodied inside DNA sequence dna, therefore graphene gene sensor can be by DNA probe crystal
Pipe is constituted, and by the double-spiral structure of complementary DNA chain composition, is gone and is detected environment and be in contact.
Preferably, i.e., electrical conductivity produced by being contacted by DNA probe with detection environment changes to generate corresponding telecommunications
Number.
Preferably, different diseases can have different detection reactions, and generated electric signal is not also identical, set in terminal
Standby middle setting information data library, the electric signal and different detection results that detection is obtained are corresponding, when receiving electric signal,
It is searched in database, and then obtains detection result.
Preferably, the wireless probe can be led to by ZIGBEE agreement or Bluetooth protocol or WIFI with terminal
Letter.
Fig. 3 shows the structural block diagram of the supersonic imaging apparatus of one embodiment of the invention offer, while Fig. 4 shows this hair
The perspective view of a bright embodiment.The equipment includes:
Detecting module: being set in the wireless ultrasound probe in supersonic imaging apparatus, is provided with stone on the detecting module
Wireless ultrasound probe is placed into subject's body by mertenyl because of sensor.
This micro radio ultrasonic probe of the invention, can be by directly acting on the epidermis of subject or by micro-
Invasive procedures are implanted into human body, carry out external or intracorporal genetic test, meanwhile, intracorporal detection can also act on different
Organ and position, therefore, compared to detection reagent or the mode of detection box, more flexibly, the scope of application is also wider.
Conversion module: being set in the wireless ultrasound probe in supersonic imaging apparatus, and graphene gene sensor is detected
The intracorporal environmental information of obtained people is converted into electric signal.
Further include a sending module in wireless ultrasound probe: the electric signal that the conversion module generates being sent to terminal and is set
It is standby.
Graphene is a kind of structure and the metastable novel nano-material of performance, there is good mechanical stretching and electronics
Attribute.Nano-sensor based on graphene has been obtained now to be widely applied.Pass through each graphene atom and induction
Environment is in contact, and the electrical properties of graphene can be changed by this contact.It therefore can be by this characteristic, by stone
The environmental information that black alkene sensor is contacted with induction environment is converted into electric signal and is transmitted.
It is provided with a receiving module in terminal device: being set on terminal device, receives the electricity that the sending module is sent
Signal.
Hot-tempered module is gone in amplification: being set on terminal device, the electric signal that the receiving module is sent is amplified
Hot-tempered processing.
For under normal circumstances, the detection environment of ultrasonic probe is generally all more complicated, in order to promoted detection precision and
Accuracy, can amplify and go hot-tempered processing by electric signal, and amplify and to go hot-tempered algorithm to have very big, the present invention to this not
Do specific restriction.
Processing module: being set on terminal device, and the electric signal received is carried out calculation processing, obtains detection result.
Ultrasonic probe by amplification go it is hot-tempered after electric signal by wireless communication agreement be sent to terminal device carry out it is further
Processing and judgement, finally obtain the result of detection.
Fig. 5 shows the cross-sectional view of the embodiment of the present invention, it is preferable that the graphene gene sensor have by
DNA probe transistor composition based on graphene, the DNA probe includes the double-spiral structure of two complementary dna chains composition.
The principle that many diseases can detected from gene is that the gene of disease can be embodied inside DNA sequence dna, because
This graphene gene sensor can be made of DNA probe transistor, pass through the double helix knot of complementary DNA chain composition
Structure goes to be in contact with detection environment.
Preferably, i.e., electrical conductivity produced by being contacted by DNA probe with detection environment changes to generate corresponding telecommunications
Number.
Preferably, different diseases can have different detection reactions, and generated electric signal is not also identical, set in terminal
Standby middle setting information data library, the electric signal and different detection results that detection is obtained are corresponding, when receiving electric signal,
It is searched in database, and then obtains detection result.
Preferably, sending module passes through ZIGBEE agreement or bluetooth or the wifi connection terminal device.
The above describes the embodiments of the present invention, it should be appreciated to those skilled in the art that this is merely illustrative of,
Those skilled in the art without departing from the principle and essence of the present invention, can make numerous variations to embodiment
Or modification, but these change and modification each fall within protection scope of the present invention.
Claims (10)
1. a kind of gene tester applied to supersonic imaging apparatus comprising the steps of:
Step 1: being provided with micro radio ultrasonic probe on the supersonic imaging apparatus, be provided with stone on the wireless ultrasound probe
Wireless ultrasound probe is placed into subject's body by mertenyl because of sensor；Step 2: by graphene gene sensor by
The intracorporal environmental information of people is converted into electric signal；Step 3: electric signal is amplified into hot-tempered processing；Step 4: by treated
Electric signal carries out calculation processing on the terminal device, obtains detection result.
2. gene tester according to claim 1, it is characterised in that: the graphene gene sensor is by being based on stone
The DNA probe transistor composition of black alkene, the DNA probe includes the double-spiral structure of two complementary dna chains composition.
3. gene tester according to claim 2, it is characterised in that: the DNA probe by with target cell into
Row coupling, when detecting that characteristics of electrical conductivity changes, generation environment information electric signal.
4. gene tester according to claim 1, it is characterised in that: be provided with information data in the terminal device
Library includes the corresponding detection result of different electrical signals in the information database, and the terminal device is according on the DNA probe
The environmental information electric signal of report, is inquired in the information database, obtains final detection result.
5. gene tester according to claim 1, it is characterised in that: the wireless ultrasound probe is assisted by ZIGBEE
View or bluetooth or the wifi connection terminal device.
6. a kind of gene detection equipment applied to supersonic imaging apparatus, comprising:
Detecting module: being set in the wireless ultrasound probe in supersonic imaging apparatus, is provided with graphene on the detecting module
Wireless ultrasound probe is placed into subject's body by gene sensor；
Conversion module: being set in the wireless ultrasound probe in supersonic imaging apparatus, and graphene gene sensor is detected to obtain
The intracorporal environmental information of people be converted into electric signal；
Sending module: the electric signal that the conversion module generates is sent to terminal device；
Receiving module: being set on terminal device, receives the electric signal that the sending module is sent；
Hot-tempered module is gone in amplification: being set on terminal device, the electric signal that the receiving module is sent is amplified hot-tempered place
Reason；
Processing module: being set on terminal device, and the electric signal received is carried out calculation processing, obtains detection result.
7. gene detection equipment according to claim 6, the graphene gene sensor is visited by the DNA based on graphene
Raphide pipe composition, the DNA probe includes the double-spiral structure of two complementary dna chains composition.
8. gene detection equipment according to claim 7, it is characterised in that: the DNA probe by with target cell into
Row coupling, when detecting that characteristics of electrical conductivity changes, generation environment information electric signal.
9. gene detection equipment according to claim 6, it is characterised in that: be provided with information data in the terminal device
Library includes the corresponding detection result of different electrical signals in the information database, and the terminal device is according to the sending module
The environmental information electric signal reported, is inquired in the information database, obtains final detection result.
10. gene detection equipment according to claim 6, it is characterised in that: the sending module passes through ZIGBEE agreement
Either bluetooth or the wifi connection terminal device.
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| CN201811411479.2A CN109431538A (en) | 2018-11-24 | 2018-11-24 | A kind of gene tester and equipment applied to supersonic imaging apparatus |
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| CN201811411479.2A CN109431538A (en) | 2018-11-24 | 2018-11-24 | A kind of gene tester and equipment applied to supersonic imaging apparatus |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320998A1 (en) * | 2014-05-07 | 2015-11-12 | Dan Hester | Device, system and method for killing viruses in blood |
| CN105372435A (en) * | 2014-08-26 | 2016-03-02 | 中国科学院苏州纳米技术与纳米仿生研究所 | Biological detection system based on graphene and making and integrating methods thereof |
| US20170367578A1 (en) * | 2015-01-26 | 2017-12-28 | Northeastern University | Ultrasonic Network for Wearable Devices |
| CN108700535A (en) * | 2015-12-23 | 2018-10-23 | 加利福尼亚大学董事会 | Nano-sensor for detection of nucleic acids and discriminating |
-
2018
- 2018-11-24 CN CN201811411479.2A patent/CN109431538A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320998A1 (en) * | 2014-05-07 | 2015-11-12 | Dan Hester | Device, system and method for killing viruses in blood |
| CN105372435A (en) * | 2014-08-26 | 2016-03-02 | 中国科学院苏州纳米技术与纳米仿生研究所 | Biological detection system based on graphene and making and integrating methods thereof |
| US20170367578A1 (en) * | 2015-01-26 | 2017-12-28 | Northeastern University | Ultrasonic Network for Wearable Devices |
| CN108700535A (en) * | 2015-12-23 | 2018-10-23 | 加利福尼亚大学董事会 | Nano-sensor for detection of nucleic acids and discriminating |
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