CN109381167A - Bimodal endoscope apparatus based on liquid lens self-focusing - Google Patents
Bimodal endoscope apparatus based on liquid lens self-focusing Download PDFInfo
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- CN109381167A CN109381167A CN201811547208.XA CN201811547208A CN109381167A CN 109381167 A CN109381167 A CN 109381167A CN 201811547208 A CN201811547208 A CN 201811547208A CN 109381167 A CN109381167 A CN 109381167A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
- A61B1/00167—Details of optical fibre bundles, e.g. shape or fibre distribution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- Heart & Thoracic Surgery (AREA)
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- Public Health (AREA)
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- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endoscopes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
A kind of bimodal endoscope apparatus based on liquid lens self-focusing, it include: shell, it is set to the rotary scanning cavity that reflecting mirror is had in shell, wherein: the OCE signal and fluorescence signal that rotary scanning cavity receives exciting light and output sample reflection by single mode optical fiber and multimode fibre respectively are to realize panoramic scanning, the present invention is by integrating OCE and FLE technology, Real-time High Resolution varifocal imaging is carried out to the structure and function inside organism, precisely effective morphological structure information image is provided accurately to monitor the early detection of gastrointestinal system disease, the quantitative optical for providing highly sensitive high specific simultaneously is concerned with and fluorescence two and three dimensions bimodal image.
Description
Technical field
It is specifically a kind of double based on liquid lens self-focusing the present invention relates to a kind of technology of medical instruments field
Mode endoscope apparatus realizes highly sensitive, high specific fluorescence endoscopic imaging using doubly clad optical fiber, while can be realized pair
Complicated irregular structure organism carry out it is automatic focus optical coherence imaging, be a kind of two kinds of collection with automatic focusing characteristics at
The endoscope being integrated as mode.
Background technique
Currently, endoscope optical is detected by common application in clinical disease, as fluorescence endoscope utilizes extrinsic fluorescence
Molecular probe target target organism realize the highly sensitive imaging of molecular functional, but which lack to organism morphology with
Structure imaging, especially to the three-dimensional imaging of tissue chromatography, there are limitations.And based on the weak relevant backscatter signal measurement of optics
Optical coherence tomography (Optical Coherence endoscopy, OCE), optical contrast with higher, high score
It distinguishes, and the advantages such as non-intrusive, may be implemented to carry out real-time living body titanium miniplate structure, substance component to high scattering material organism
And the functional informations three-dimensional imaging such as blood flow.Energy is imaged in the defect that single modality technology always has its intrinsic, multi-modal fusion
The deficiency for enough making up single-mode is the trend of modern biotechnology photomedicine development.However existing multi-modal endoscopic technique
In such as fluorescence and Photoacoustic endoscope, although fluorescence mode can be realized the detection imaging of the fluorescence signal of tissue early lesion,
But it is the absence of the fine-feature of the low indistinguishable lesion component of morphological structure information, resolution ratio；Although optoacoustic endoscopy microscope
It can be improved image resolution ratio, but imaging depth has certain limitation；Simultaneously as the surface heterogeneity of intestinal tissue is led
Cause the imaging of generation defocus and image fault of the focusing focus of detection light beam.
Summary of the invention
The present invention In view of the above shortcomings of the prior art, discloses in a kind of bimodal based on liquid lens self-focusing
Endoscopic device, for fusion optical coherent endoscope be imaged (Optical coherence endoscopy, OCE) and fluorescence endoscopic at
As the integrated bimodal endoscope of (Fluorescence endoscopy, FLE), the structure inside organism not only may be implemented
With function Real-time High Resolution varifocal imaging, both of which is may be implemented in gastrointestinal tract disease in the design also focused automatically using liquid
In disease, solve other optics based endoscopic imaging technologies because enteron aisle inner surface is irregular, out-of-flatness due to cause hot spot defocus, lead to image
Problem fuzzy, under resolution ratio, is realized to highly sensitive fluorescence molecule image.The present invention can be the morning of gastrointestinal system disease
Phase detection provides precisely effectively highly sensitive high specific, high-resolution optical coherence and fluorescence two and three dimensions bimodal image.
The present invention is achieved by the following technical solutions:
The present invention includes: shell, is set to the intracorporal rotary scanning cavity of shell, in which: rotary scanning cavity passes through single mode
The OCE signal and fluorescence signal that optical fiber and multimode fibre receive exciting light and output sample reflection respectively are to realize panoramic scanning.
The rotary scanning cavity includes: the reflecting mirror set gradually, non-spherical lens, autohemagglutination focus liquid lens, disappears
Color difference lens, variable pinhole diaphragm and beam collimator, in which: beam collimator by doubly clad optical fiber and fiber coupler with
Single mode optical fiber and multimode fibre are connected to transmit OCE signal and fluorescence signal, and incident exciting light enters optical fiber from single mode optical fiber
Coupler, passes sequentially through variable pinhole diaphragm after beam collimator collimates and achromatic lens expands, and is incident on self-focusing liquid
Body lens and non-spherical lens obtain focus on light beam and impinge perpendicularly on reflecting mirror, and be radiated on the sample of hull outside, come from
The scattering single-mode optics and multimode light of sample return to optical fiber collimator by identical optical path, by fiber coupler and double clad
Optical fiber exports single mode OCE signal by single mode optical fiber and carries out image reconstruction.
The shell and rotary scanning cavity is equipped with corresponding cavity scanning window to transmit exciting light and reflected light；Institute
The reflecting mirror stated is preferably spherical reflector, and the cavity on reflection kernel face shell scans window.
The rotary scanning containment portion is connected to realize axial rotation with micro machine.
The fiber coupler includes: fiber core with single-mold and multimode fibre core, in which: fiber core with single-mold by multimode fibre fibre core
Inner cladding is surround, and to realize the separation of OCE Yu FLE signal, single mode signal is and fine in single mode by the fibre core of doubly clad optical fiber
The output of core port；Multimode signal is transferred to multimode fibre fibre core from doubly clad optical fiber, and exports in multimode fibre core port；It realizes double
The output of mode signals.
The multiplying power that expands of the achromatic lens is 2-3 times, to meet the clear aperature for occupying autohemagglutination focus liquid lens,
Realize maximum light passing rate.
The focal length of the non-spherical lens is 5-8mm, numerical aperture 0.4-0.55, anti-reflection film 650-1050nm, is somebody's turn to do
Non-spherical lens avoids the spherical aberration that transmitted wave introduces when focusing and beam collimation, while reducing to achromatism spherical mirror
Using number, keep interior snooping header structure more integrated, more lightly；It reduces and is moved before and after being carried out inside pipeline type organism
Dynamic stress.
The autohemagglutination focus liquid lens realize fast zoom by the variation of impressed current, guarantee each focal beam spot
All organizationally optimal focussing planes；Its clear aperature 2-2.5mm, thickness 3-3.5mm；The autohemagglutination focus liquid lens utilize Jie
Matter electrowetting principle changes the curvature of drop by applied voltage to realize automatic focusing and zoom function；The self-focusing liquid
When gastrointestinal system is imaged, the performance of autozoom may be implemented to solve the imaging of surface imperfection tissue lens
Because caused by defocus the phenomenon that image fault.
The rotary scanning cavity is sealing leakage preventing structure and reflecting mirror and cavity synchronous rotary, is had by cavity rotation
Effect avoids reflecting mirror rotation from having to the sealing problem connecting by main cavity swingle with reflecting mirror.
Technical effect
OCE does not provide fluorescent molecule functional information in the prior art, for such as nano material, can not differentiate nanometer
The difference of material and biological composition substance can not accomplish small-molecule drug tracking and release and metabolism in vivo；And fluorescence
Although imaging can carry out targeting label by carrying out fluorescent dye to these substances, it is tracked in body with fluorescent molecular probe
The processes such as interior motion profile, release and metabolism, but the fine body structural information of organizer can not be provided.The present invention
Not only have the ability of OCE based endoscopic imaging, while being also equipped with the ability of FLE based endoscopic imaging；Using autohemagglutination focus liquid lens
Realize the organism bimodal imaging different because of its surface imperfection, surface relief to gastrointestinal system；And using aspherical
Lens greatly simplify the interior use number for spying upon lens in front；The design of doubly clad optical fiber, realizing simple optical fiber can be complete
It is imaged at the real-time bimodal micromorphology mechanism of both modalities which Signal separator and is merged with the fluorescent molecule function of high specific
Imaging；Change the structure that design simplifies snooping head in bimodal, can for can be clinical gastrointestinal system and blood vessel endoscope at
As providing Real-time High Resolution rate, high contrast, institutional framework and fluorescent molecule the function image information abundant of high specific, this
Invention can be realized as bimodal based endoscopic imaging using single fiber, and system structure more simplifies, stability, miniaturization.
Detailed description of the invention
Fig. 1 is the whole device structural schematic diagram of invention；
Fig. 2 is rotary scanning cavity body structure schematic diagram；
Fig. 3 is embodiment effect diagram；
In figure: a is commonly without varifocal imaging；B is present invention imaging.
Specific embodiment
As shown in Figure 1, Figure 2, Figure 3 shows, include in the present embodiment: fiber core with single-mold 1, multimode fibre core 2, cable 3, optical fiber and cable
Shell 4, outer chamber protective case 5, endoscope outer chamber 6, micro machine 7, spherical reflector 8, exocoel swept-volume window 9, fiber coupling
Device 10, achromatic lens 11 and 12, doubly clad optical fiber 13, beam collimator 14, variable pinhole diaphragm 15, rotary scanning cavity
16, autohemagglutination focus liquid lens 17, non-spherical lens 18, main exocoel swept-volume window 19, rotating shaft 20, in which: spherical reflector
8, achromatic lens 11 and 12, beam collimator 14, autohemagglutination focus liquid lens 17, doubly clad optical fiber couple 10, doubly clad optical fiber
Beam 13 and non-spherical lens 18 are located in rotary scanning cavity 16.
The autohemagglutination focus liquid lens 17 according to Electrowetting principle, by change the diaphragm in its structure and its inside
Fluid curent change, and change the curvature of liquid mould, change focal length.The liquid lens has structure simple, low in energy consumption, zoom
The advantages that time is short is suitably applied quickly focusing endoscopic imaging mechanism.It has round small and exquisite resemblance, diameter 0.2-
3mm, clear aperature 2-4mm, length 2-4mm, focal length 8-12mm, 680-1300nm.
The present embodiment is related to the real-time endoscopic imaging method of bimodal of the zoom of above-mentioned apparatus, comprising the following steps:
The first step, excitation light source input incident light by fiber core with single-mold 1, enter rotary scanning by doubly clad optical fiber beam 13
Pass through beam collimator 14 in cavity 16, then rotary scanning cavity, then adjusts spot size, filtering through variable pinhole diaphragm 15
Stray light is expanded through achromatic lens 11,12, the parallel beam incident after collimator and extender to 17 surface of autohemagglutination focus liquid lens,
Using non-spherical lens 18, focus on light beam is incident on spherical reflector 8, is reflected into the table for being surrounded on the sample 21 of shell surrounding
Face, entire rotary scanning cavity 16 connect micro machine 7 with cable 3 by shaft 10 and rotate, and pass through main 19 He of exocoel swept-volume window
Exocoel swept-volume window 9 realizes 360 ° of all standing scannings of circumference；
The back scattering optical signal that second step, focal beam spot induce tissue generation in biological tissue passes through identical optical path
Autohemagglutination focus liquid lens 17 are returned to, double mode optical signal is separated by doubly clad optical fiber and fiber coupler 10 and is obtained respectively
It is exported to single mode OCE signal by fiber core with single-mold 1, obtains multimode FLE signal and exported by multimode fibre core 2, obtained through image procossing
To both modalities which undertissue structure as shown in Figure 3b and fluorescent molecule energy multidimensional bimodal based endoscopic imaging.
Above-mentioned specific implementation can by those skilled in the art under the premise of without departing substantially from the principle of the invention and objective with difference
Mode carry out local directed complete set to it, protection scope of the present invention is subject to claims and not by above-mentioned specific implementation institute
Limit, each implementation within its scope is by the constraint of the present invention.
Claims (9)
1. a kind of bimodal endoscope apparatus based on liquid lens self-focusing characterized by comprising shell is set to shell
The rotary scanning cavity of reflecting mirror is had in vivo, in which: rotary scanning cavity is received respectively by single mode optical fiber and multimode fibre
The OCE signal and fluorescence signal of exciting light and output sample reflection are to realize panoramic scanning；
The rotary scanning cavity includes: the reflecting mirror set gradually, non-spherical lens, autohemagglutination focus liquid lens, achromatism
Lens, variable pinhole diaphragm and beam collimator, in which: beam collimator passes through doubly clad optical fiber and fiber coupler and single mode
Optical fiber and multimode fibre are connected to transmit OCE signal and fluorescence signal, and incident exciting light enters fiber coupling from single mode optical fiber
Device, passes sequentially through variable pinhole diaphragm after beam collimator collimates and achromatic lens expands, and it is saturating to be incident on self-focusing liquid
Mirror and non-spherical lens obtain focus on light beam and impinge perpendicularly on reflecting mirror, and be radiated on the sample of hull outside, come from sample
Scattering single-mode optics and multimode light optical fiber collimator returned to by identical optical path, by fiber coupler and double clad light
Fibre exports single mode OCE signal by single mode optical fiber and carries out image reconstruction.
2. the apparatus according to claim 1, characterized in that the shell and rotary scanning cavity is equipped with corresponding chamber
For swept-volume window to transmit exciting light and reflected light, which is spherical reflector, reflection kernel face rotary scanning cavity
And the cavity on shell scans window.
3. the apparatus according to claim 1, characterized in that the rotary scanning cavity is connected to realize axis with micro machine
To rotation.
4. the apparatus according to claim 1, characterized in that the fiber coupler includes: that fiber core with single-mold and multimode are fine
Core, in which: fiber core with single-mold is surround by the fibre core inner cladding of multimode fibre, to realize the separation of OCE Yu FLE signal, single mode letter
It number is exported by the fibre core of doubly clad optical fiber, and in fiber core with single-mold port；Multimode signal is transferred to multimode light from doubly clad optical fiber
Long and slender core, and exported in multimode fibre core port；Realize the output of bimodal signal.
5. the apparatus according to claim 1, characterized in that the multiplying power that expands of the achromatic lens is 2-3 times, with full
Foot occupies the clear aperature of autohemagglutination focus liquid lens, realizes maximum light passing rate.
6. the apparatus according to claim 1, characterized in that the focal length of the non-spherical lens is 5-8mm, numerical aperture
For 0.4-0.55mm, anti-reflection film 650-1050nm.
7. the apparatus according to claim 1, characterized in that the change that the autohemagglutination focus liquid lens pass through impressed current
Change, realizes fast zoom, guarantee each focal beam spot organizationally optimal focussing plane, clear aperature 2-2.5mm,
Thickness 3-3.5mm.
8. the apparatus according to claim 1, characterized in that the rotary scanning cavity is sealing leakage preventing structure and reflection
Mirror and cavity synchronous rotary.
9. a kind of panoramic scanning method according to any of the above-described claim described device, which comprises the following steps:
The first step, excitation light source by fiber core with single-mold input incident light, by doubly clad optical fiber Shu Yici by beam collimator,
Variable pinhole diaphragm, achromatic lens, autohemagglutination focus liquid lens, non-spherical lens form focus on light beam, are reflected by reflecting mirror
To the surface of sample；
The back scattering optical signal that second step, focal beam spot induce tissue generation in biological tissue is returned to by identical optical path
Autohemagglutination focus liquid lens carry out double mode optical signal to respectively obtain single mode by doubly clad optical fiber and fiber coupler
OCE signal is exported by fiber core with single-mold, is obtained multimode FLE signal and is exported by multimode fibre core, obtains two kinds of moulds through image procossing
State undertissue structure and fluorescent molecule energy multidimensional bimodal based endoscopic imaging.
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| CN201811547208.XA CN109381167A (en) | 2018-12-18 | 2018-12-18 | Bimodal endoscope apparatus based on liquid lens self-focusing |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
| CN111227771A (en) * | 2020-01-09 | 2020-06-05 | 上海交通大学 | Self-focusing OCT endoscope with variable working distance |
| CN112965085A (en) * | 2021-02-05 | 2021-06-15 | 山东国耀量子雷达科技有限公司 | Laser radar receiving module, laser radar and atmospheric aerosol detection method |
| CN115670385A (en) * | 2022-11-03 | 2023-02-03 | 上海交通大学 | Intravascular fiber probe lateral three-dimensional scanning device and control method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110881942A (en) * | 2019-12-11 | 2020-03-17 | 上海交通大学 | OCT-based bimodal optical fiber endoscope device |
| CN111227771A (en) * | 2020-01-09 | 2020-06-05 | 上海交通大学 | Self-focusing OCT endoscope with variable working distance |
| CN112965085A (en) * | 2021-02-05 | 2021-06-15 | 山东国耀量子雷达科技有限公司 | Laser radar receiving module, laser radar and atmospheric aerosol detection method |
| CN115670385A (en) * | 2022-11-03 | 2023-02-03 | 上海交通大学 | Intravascular fiber probe lateral three-dimensional scanning device and control method |
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