CN109331337B - Amplitude-variable and pulse-width-variable symmetric pulse wave transcranial stimulation device and method - Google Patents

Amplitude-variable and pulse-width-variable symmetric pulse wave transcranial stimulation device and method Download PDF

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CN109331337B
CN109331337B CN201811341815.0A CN201811341815A CN109331337B CN 109331337 B CN109331337 B CN 109331337B CN 201811341815 A CN201811341815 A CN 201811341815A CN 109331337 B CN109331337 B CN 109331337B
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吴军发
吴华伟
李尊
童后权
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Abstract

The invention relates to a transcranial stimulation instrument, in particular to a symmetrical pulse wave transcranial stimulation device and method with variable amplitude and variable pulse width. The device and method solve the problem that an existing transcranial stimulation instrument is not ideal in stimulation effect. The symmetrical pulse wave transcranial stimulation device with the variable amplitude and the variable pulse width comprises a single chip microcomputer, a first to third operational amplifier, a first digital potentiometer, a second digital potentiometer, a first triode, a second triode, a first diode, a second diode, a first capacitor, a second capacitor, a first to tenth resistor, wherein the first triode is an NPN type triode, the second triode is a PNP type triode, the output end of the first operational amplifier is connected with the single chip microcomputer, and the positive input end of the first operational amplifier is connected with the output end of the first operational amplifier through the first resistor and is connected with the output end of the second operational amplifier through the third resistor and the fifth resistor in sequence. The symmetrical pulse wave transcranial stimulation device and method are suitable for transcranial stimulation.

Description

Amplitude-variable and pulse-width-variable symmetric pulse wave transcranial stimulation device and method
Technical Field
The invention relates to a transcranial stimulation instrument, in particular to a device and a method for transcranial stimulation by symmetrical pulse waves with variable amplitude and variable pulse width.
Background
The transcranial stimulation instrument is an instrument which utilizes low-intensity micro-current to stimulate the brain, change abnormal brain waves and promote the brain to secrete a series of neurotransmitters and hormones closely related to anxiety, depression, insomnia and other diseases. Under the condition of the prior art, the transcranial stimulation instrument generally adopts square waves with constant amplitude and frequency as the waveform of the stimulation current, so that the stimulation effect is obviously weakened after the transcranial stimulation instrument is used for a long time, and the stimulated cells have polarization phenomenon, so that the stimulation effect is not ideal. Therefore, a brand new transcranial stimulation instrument needs to be invented to solve the problem that the stimulation effect of the existing transcranial stimulation instrument is not ideal.
Disclosure of Invention
The invention provides a variable-amplitude and variable-pulse-width symmetric pulse wave transcranial stimulation device and method, aiming at solving the problem that the stimulation effect of the existing transcranial stimulation instrument is not ideal.
The invention is realized by adopting the following technical scheme:
a variable-amplitude and variable-pulse-width symmetric pulse wave transcranial stimulation device comprises a single chip microcomputer, a first operational amplifier, a second operational amplifier, a third operational amplifier, a first digital potentiometer, a second digital potentiometer, a first triode, a second triode, a first diode, a second diode, a first capacitor, a second capacitor and a first resistor, a second resistor, a third resistor, a fourth resistor, a fifth resistor, a sixth resistor, a fourth resistor, a sixth resistor, a fourth resistor, a sixth resistor, a fourth resistor, a sixth resistor, a fourth resistor, a sixth resistor, a fourth and a fourth resistor, a fourth and a sixth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth and a fourth resistor, a fourth; the first triode is an NPN type triode; the second triode is a PNP type triode;
the output end of the first operational amplifier is connected with the single chip microcomputer; the positive input end of the first operational amplifier is connected with the output end of the first operational amplifier through a first resistor on one hand, and is connected with the output end of the second operational amplifier through a third resistor and a fifth resistor in sequence on the other hand; the negative input end of the first operational amplifier is connected with the output end of the first operational amplifier through a second resistor on one hand, and is connected with the output end of the second operational amplifier through a fourth resistor on the other hand; the positive input end of the second operational amplifier is connected with the single chip microcomputer; the negative input end of the second operational amplifier is connected with the reference voltage end;
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the first digital potentiometer are all connected with the single chip microcomputer; a first fixed end of the first digital potentiometer is connected with the positive power supply end, and a second fixed end of the first digital potentiometer is connected with the output end of the third operational amplifier; the sliding end of the first digital potentiometer is connected with the base electrode of the first triode; the collector of the first triode is connected with the cathode of the first diode; the anode of the first diode is connected with the output end of the second operational amplifier through the sixth resistor and the fifth resistor in sequence; an emitter of the first triode is connected with the output end of the third operational amplifier through a ninth resistor;
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the second digital potentiometer are all connected with the single chip microcomputer; the first fixed end of the second digital potentiometer is connected with the output end of the third operational amplifier, and the second fixed end of the second digital potentiometer is connected with the negative power supply end; the sliding end of the second digital potentiometer is connected with the base electrode of the second triode; the collector of the second triode is connected with the anode of the second diode; the cathode of the second diode is connected with the output end of the second operational amplifier through the sixth resistor and the fifth resistor in sequence; an emitter of the second triode is connected with the output end of the third operational amplifier through a tenth resistor;
the positive input end of the third operational amplifier is connected with the single chip microcomputer; the negative input end of the third operational amplifier is connected with the reference voltage end; one end of the first capacitor is connected with the anode of the first diode through the seventh resistor, and the other end of the first capacitor is connected with the positive power supply end; one end of the second capacitor is connected with the anode of the first diode through the eighth resistor, and the other end of the second capacitor is connected with the negative power supply end.
A variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation method (the method is realized based on the variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation device of the invention), the method is realized by adopting the following steps:
firstly, selecting two ear clip electrodes; the two ear clip electrodes are respectively clipped on two ears of a patient, and two input ends of each ear clip electrode are respectively connected with two ends of the sixth resistor;
then, starting the single chip microcomputer; under the control of the singlechip, the second operational amplifier, the third operational amplifier, the first digital potentiometer and the second digital potentiometer work according to the following conditions:
when the output end voltage of the second operational amplifier is positive voltage, the output end voltage of the third operational amplifier is negative voltage, the sliding end of the first digital potentiometer is high level, and the sliding end of the second digital potentiometer is low level, so that the first triode is conducted, the second triode is cut off, and the currents flowing through the two ear clip electrodes are positive currents;
when the output end voltage of the second operational amplifier is negative voltage, the output end voltage of the third operational amplifier is positive voltage, the sliding end of the first digital potentiometer is low level, and the sliding end of the second digital potentiometer is high level, so that the first triode is cut off, the second triode is conducted, and the currents flowing through the two ear clip electrodes are negative currents;
under the constraint of the above conditions, the waveforms of the current flowing through the two ear clip electrodes are symmetrical pulse waves with variable amplitude and variable pulse width; the function expression of the symmetrical pulse wave with variable amplitude and variable pulse width is as follows:
Figure BDA0001862759780000041
Figure BDA0001862759780000042
in formulae (1) to (2): i is the current flowing through the two ear clip electrodes; t is time; t is a period, and the value of T is randomly set by software; n is a non-negative integer; i is1、I2、I3、I4Are all amplitude values; i is0Is a constant.
Compared with the existing transcranial stimulation instrument, the amplitude-variable and pulse-width-variable symmetric pulse wave transcranial stimulation device and method do not adopt square waves with constant amplitude and frequency as the waveform of the stimulation current any more, but adopt symmetric pulse waves with variable amplitude and pulse width as the waveform of the stimulation current. Compared with the square wave with constant amplitude and frequency, the symmetrical pulse wave with variable amplitude and variable pulse width can continuously and regularly change the stimulation intensity and the stimulation time, so that the stimulation effect is not weakened after the device is used for a long time, and the stimulated cells are not polarized, thereby ensuring the stimulation effect to be more ideal.
The invention has reasonable structure and ingenious design, effectively solves the problem of non-ideal stimulation effect of the existing transcranial stimulation instrument, and is suitable for transcranial stimulation.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a waveform diagram (period is 20s) of one period of a symmetrical pulse wave with variable amplitude and variable pulse width in the present invention.
Detailed Description
A variable-amplitude and variable-pulse-width symmetric pulse wave transcranial stimulation device comprises a single chip microcomputer U, first to third operational amplifiers AR 1-AR 3, a first digital potentiometer T1, a second digital potentiometer T2, a first triode Q1, a second triode Q2, a first diode D1, a second diode D2, a first capacitor C1, a second capacitor C2 and first to tenth resistors R1-R10; the first triode Q1 is an NPN type triode; the second triode Q2 is a PNP type triode;
the output end of the first operational amplifier AR1 is connected with the single chip microcomputer U; the positive input end of the first operational amplifier AR1 is connected to the output end of the first operational amplifier AR1 through a first resistor R1, and is connected to the output end of the second operational amplifier AR2 through a third resistor R3 and a fifth resistor R5 in sequence; the negative input end of the first operational amplifier AR1 is connected to the output end of the first operational amplifier AR1 through a second resistor R2 on the one hand, and is connected to the output end of the second operational amplifier AR2 through a fourth resistor R4 on the other hand; the positive input end of the second operational amplifier AR2 is connected with the singlechip U; the negative input end of the second operational amplifier AR2 is connected with a reference voltage end VREF;
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the first digital potentiometer T1 are all connected with the single chip microcomputer U; a first fixed end of the first digital potentiometer T1 is connected with a positive power supply terminal VCC, and a second fixed end is connected with an output end of the third operational amplifier AR 3; the sliding end of the first digital potentiometer T1 is connected with the base electrode of the first triode Q1; the collector of the first triode Q1 is connected with the cathode of the first diode D1; the anode of the first diode D1 is connected with the output end of the second operational amplifier AR2 through a sixth resistor R6 and a fifth resistor R5 in sequence; an emitter of the first triode Q1 is connected with the output end of the third operational amplifier AR3 through a ninth resistor R9;
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the second digital potentiometer T2 are all connected with the single chip microcomputer U; a first fixed end of the second digital potentiometer T2 is connected with the output end of the third operational amplifier AR3, and a second fixed end of the second digital potentiometer T2 is connected with a negative power supply end NVCC; the sliding end of the second digital potentiometer T2 is connected with the base electrode of the second triode Q2; the collector of the second triode Q2 is connected with the anode of the second diode D2; the cathode of the second diode D2 is connected with the output end of the second operational amplifier AR2 through a sixth resistor R6 and a fifth resistor R5 in sequence; an emitter of the second triode Q2 is connected with the output end of the third operational amplifier AR3 through a tenth resistor R10;
the positive input end of the third operational amplifier AR3 is connected with the singlechip U; the negative input end of the third operational amplifier AR3 is connected with a reference voltage end VREF; one end of the first capacitor C1 is connected with the anode of the first diode D1 through the seventh resistor R7, and the other end is connected with the positive power supply terminal VCC; one end of the second capacitor C2 is connected to the anode of the first diode D1 through the eighth resistor R8, and the other end is connected to the negative power supply terminal NVCC.
The single chip microcomputer U adopts an STM32 series single chip microcomputer; the first digital potentiometer T1 and the second digital potentiometer T2 both adopt 256-bit digital potentiometers.
A variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation method (the method is realized based on the variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation device of the invention), the method is realized by adopting the following steps:
firstly, selecting two ear clip electrodes; the two ear clip electrodes are respectively clipped on two ears of a patient, and two input ends of each ear clip electrode are respectively connected with two ends of the sixth resistor R6;
then, starting the singlechip U; under the control of the singlechip U, the second operational amplifier AR2, the third operational amplifier AR3, the first digital potentiometer T1 and the second digital potentiometer T2 work according to the following conditions:
when the output end voltage of the second operational amplifier AR2 is a positive voltage, the output end voltage of the third operational amplifier AR3 is a negative voltage, the sliding end of the first digital potentiometer T1 is a high level, and the sliding end of the second digital potentiometer T2 is a low level, so that the first triode Q1 is turned on, the second triode Q2 is turned off, and thus the currents flowing through the two ear clip electrodes are both positive currents;
when the output end voltage of the second operational amplifier AR2 is a negative voltage, the output end voltage of the third operational amplifier AR3 is a positive voltage, the sliding end of the first digital potentiometer T1 is a low level, and the sliding end of the second digital potentiometer T2 is a high level, so that the first triode Q1 is turned off, the second triode Q2 is turned on, and the currents flowing through the two ear clip electrodes are negative currents;
under the constraint of the above conditions, the waveforms of the current flowing through the two ear clip electrodes are symmetrical pulse waves with variable amplitude and variable pulse width; the function expression of the symmetrical pulse wave with variable amplitude and variable pulse width is as follows:
Figure BDA0001862759780000081
Figure BDA0001862759780000082
in formulae (1) to (2): i is the current flowing through the two ear clip electrodes; t is time; t is a period, and the value of T is randomly set by software; n is a non-negative integer; i is1、I2、I3、I4Are all amplitude values; i is0Is a constant.

Claims (3)

1. A variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation device is characterized in that: the circuit comprises a single chip microcomputer (U), first to third operational amplifiers (AR 1-AR 3), a first digital potentiometer (T1), a second digital potentiometer (T2), a first triode (Q1), a second triode (Q2), a first diode (D1), a second diode (D2), a first capacitor (C1), a second capacitor (C2) and first to tenth resistors (R1-R10); the first triode (Q1) is an NPN type triode; the second triode (Q2) is a PNP type triode;
wherein, the output end of the first operational amplifier (AR1) is connected with the singlechip (U); the positive input end of the first operational amplifier (AR1) is connected with the output end of the first operational amplifier (AR1) through a first resistor (R1), and is connected with the output end of the second operational amplifier (AR2) through a third resistor (R3) and a fifth resistor (R5) in sequence; the negative input end of the first operational amplifier (AR1) is connected with the output end of the first operational amplifier (AR1) through a second resistor (R2) on one hand, and is connected with the output end of the second operational amplifier (AR2) through a fourth resistor (R4) on the other hand; the positive input end of the second operational amplifier (AR2) is connected with the single chip microcomputer (U); the negative input end of the second operational amplifier (AR2) is connected with a reference voltage end (VREF);
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the first digital potentiometer (T1) are all connected with the single chip microcomputer (U); the first fixed end of the first digital potentiometer (T1) is connected with a positive power supply terminal (VCC), and the second fixed end is connected with the output end of the third operational amplifier (AR 3); the sliding end of the first digital potentiometer (T1) is connected with the base electrode of the first triode (Q1); the collector of the first triode (Q1) is connected with the cathode of the first diode (D1); the anode of the first diode (D1) is connected with the output end of the second operational amplifier (AR2) through a sixth resistor (R6) and a fifth resistor (R5) in sequence; an emitter of the first triode (Q1) is connected with the output end of the third operational amplifier (AR3) through a ninth resistor (R9);
the chip selection end, the serial clock end, the serial data input end and the serial data output end of the second digital potentiometer (T2) are all connected with the single chip microcomputer (U); a first fixed end of the second digital potentiometer (T2) is connected with the output end of the third operational amplifier (AR3), and a second fixed end of the second digital potentiometer is connected with a negative power supply terminal (NVCC); the sliding end of the second digital potentiometer (T2) is connected with the base electrode of the second triode (Q2); the collector of the second triode (Q2) is connected with the anode of the second diode (D2); the cathode of the second diode (D2) is connected with the output end of the second operational amplifier (AR2) through a sixth resistor (R6) and a fifth resistor (R5) in sequence; an emitter of the second triode (Q2) is connected with the output end of the third operational amplifier (AR3) through a tenth resistor (R10);
the positive input end of the third operational amplifier (AR3) is connected with the singlechip (U); the negative input end of the third operational amplifier (AR3) is connected with a reference voltage end (VREF); one end of the first capacitor (C1) is connected with the anode of the first diode (D1) through a seventh resistor (R7), and the other end is connected with a positive power supply terminal (VCC); one end of the second capacitor (C2) is connected to the anode of the first diode (D1) through an eighth resistor (R8), and the other end is connected to the negative power supply terminal (NVCC).
2. The variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation device according to claim 1, wherein: the single chip microcomputer (U) adopts an STM32 series single chip microcomputer; the first digital potentiometer (T1) and the second digital potentiometer (T2) are 256-bit digital potentiometers.
3. The variable amplitude and variable pulse width symmetric pulse wave transcranial stimulation device according to claim 1, wherein: the transcranial stimulation method of the device is realized by adopting the following steps:
firstly, selecting two ear clip electrodes; the two ear clip electrodes are respectively clipped on two ears of a patient, and two input ends of each ear clip electrode are respectively connected with two ends of a sixth resistor (R6);
then, starting a single chip microcomputer (U); under the control of a single chip microcomputer (U), a second operational amplifier (AR2), a third operational amplifier (AR3), a first digital potentiometer (T1) and a second digital potentiometer (T2) work according to the following conditions:
when the voltage of the output end of the second operational amplifier (AR2) is positive voltage, the voltage of the output end of the third operational amplifier (AR3) is negative voltage, the sliding end of the first digital potentiometer (T1) is at high level, and the sliding end of the second digital potentiometer (T2) is at low level, so that the first triode (Q1) is turned on, the second triode (Q2) is turned off, and the currents flowing through the two ear clip electrodes are positive currents;
when the voltage of the output end of the second operational amplifier (AR2) is negative voltage, the voltage of the output end of the third operational amplifier (AR3) is positive voltage, the sliding end of the first digital potentiometer (T1) is at low level, and the sliding end of the second digital potentiometer (T2) is at high level, so that the first triode (Q1) is cut off, the second triode (Q2) is conducted, and the currents flowing through the two ear clip electrodes are negative currents;
under the constraint of the above conditions, the waveforms of the current flowing through the two ear clip electrodes are symmetrical pulse waves with variable amplitude and variable pulse width; the function expression of the symmetrical pulse wave with variable amplitude and variable pulse width is as follows:
Figure FDA0003482239290000031
Figure FDA0003482239290000041
in formulae (1) to (2): i is the current flowing through the two ear clip electrodes; t is time; t is a period, and the value of T is randomly set by software; n is a non-negative integer; i is1、I2、I3、I4Are all amplitude values; i is0Is a constant.
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Publication number Priority date Publication date Assignee Title
CN2219724Y (en) * 1995-03-15 1996-02-14 徐海良 Multi-electrode meridian scanning impulse stimulator
EP2320997A1 (en) * 2008-05-13 2011-05-18 cerboMed GmbH Method to enhance neural tissue operation
CN102142833A (en) * 2011-01-24 2011-08-03 常州汇邦电子有限公司 Silicon controlled trigger circuit
CN104906689A (en) * 2015-06-09 2015-09-16 华南理工大学 Anxiety, depression and insomnia bipolar constant current therapeutic instrument
CN206482986U (en) * 2016-07-28 2017-09-12 中国人民解放军第150中心医院 A kind of intermediate frequency therapy signal generator
CN107508487A (en) * 2016-12-22 2017-12-22 长春工程学院 Pulse current source with multiple protective
CN207562223U (en) * 2017-03-23 2018-07-03 广州市千牧电子有限公司 A kind of intelligence therapeutic equipment for sick headache
CN107017795A (en) * 2017-03-31 2017-08-04 德力西(杭州)变频器有限公司 Pulse-generator circuit and its control method

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