CN109288624B - Efficient absorption hemostatic dressing and preparation method thereof - Google Patents
Efficient absorption hemostatic dressing and preparation method thereof Download PDFInfo
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- CN109288624B CN109288624B CN201810825601.4A CN201810825601A CN109288624B CN 109288624 B CN109288624 B CN 109288624B CN 201810825601 A CN201810825601 A CN 201810825601A CN 109288624 B CN109288624 B CN 109288624B
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- 238000010521 absorption reaction Methods 0.000 title claims abstract description 79
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000010410 layer Substances 0.000 claims abstract description 56
- 239000012792 core layer Substances 0.000 claims abstract description 29
- 229920005989 resin Polymers 0.000 claims abstract description 27
- 239000011347 resin Substances 0.000 claims abstract description 27
- 239000002250 absorbent Substances 0.000 claims abstract description 23
- 230000002745 absorbent Effects 0.000 claims abstract description 23
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 20
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims description 24
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 15
- 239000000661 sodium alginate Substances 0.000 claims description 15
- 235000010413 sodium alginate Nutrition 0.000 claims description 15
- 229940005550 sodium alginate Drugs 0.000 claims description 15
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 12
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 12
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 12
- 229920000642 polymer Polymers 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 11
- 239000002131 composite material Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 239000004745 nonwoven fabric Substances 0.000 claims description 9
- 239000004793 Polystyrene Substances 0.000 claims description 8
- 238000005520 cutting process Methods 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000011521 glass Substances 0.000 claims description 8
- 229920002223 polystyrene Polymers 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 239000004831 Hot glue Substances 0.000 claims description 5
- 238000013329 compounding Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical group C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 4
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- DZSVIVLGBJKQAP-UHFFFAOYSA-N 1-(2-methyl-5-propan-2-ylcyclohex-2-en-1-yl)propan-1-one Chemical compound CCC(=O)C1CC(C(C)C)CC=C1C DZSVIVLGBJKQAP-UHFFFAOYSA-N 0.000 claims description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
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- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
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- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
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- 230000002265 prevention Effects 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000035876 healing Effects 0.000 abstract description 2
- 206010051373 Wound haemorrhage Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 10
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- 208000032843 Hemorrhage Diseases 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 208000034158 bleeding Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
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- 238000004821 distillation Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
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- 230000008733 trauma Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01034—Non-adhesive bandages or dressings characterised by a property
- A61F13/01042—Absorbency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00604—Multilayer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to a high-efficiency absorption hemostatic dressing and a preparation method thereof, belonging to the technical field of medical consumables. The efficient absorption hemostatic dressing sequentially comprises a hemostatic layer, an absorption core layer, an antibacterial layer, a waterproof layer and a bottom layer, wherein the raw materials for preparing the absorption core layer comprise fluff pulp and super absorbent resin. The absorption core layer adopts an absorption structure combining the super absorbent resin and the fluff pulp, so that a large amount of blood is quickly and fully absorbed, effectively coagulated without rewet, seepage prevention and leakage prevention are ensured, and meanwhile, the wound surface rapid healing promotion film has waterproof, breathable, antibacterial and hemostatic effects, and is widely suitable for patients with moderate and severe wound bleeding.
Description
Technical Field
The invention relates to the technical field of medical consumables, in particular to a high-efficiency absorption hemostatic dressing and a preparation method thereof.
Background
The medical dressing can control wound exudate in time, prevent microorganisms from invading and infecting the wound and maintain the micro-moist environment of the wound, thereby promoting the rapid healing of the wound. According to clinical experience observation, the early bleeding amount of a common wound of a patient in orthopedics and traumatology after operation can reach as much as 100ml, and the bleeding liquid of the wound can be in a continuous exudation state. At present, sterile gauze, cotton pads, common bandages and activated carbon fibers are mostly used in the dressing, but the sterile gauze, the cotton pads and the common bandages do not have the function of preventing liquid from seeping outwards, the liquid absorption capacity of the commercially available activated carbon fiber dressing is weak, and edge fibers and surface fibers are easy to fall off, so that a large amount of bleeding at the early stage of a wound after operation often seeps outwards to pollute a bed unit, and the wide application of the dressing is limited.
Patent CN1202379A discloses a composite activated carbon dressing. The medical water-absorbing fabric is prepared by compounding high-molecular water-absorbing resin and activated carbon fibers, and is characterized in that the high-molecular water-absorbing resin is subjected to hot pressing, compounded with the activated carbon fibers to prepare a sheet, then the sheet is laminated with medical non-woven fabric to form a whole, and the sheet is wrapped by the medical non-woven fabric to form a rectangular sheet. It is non-toxic, quick in adsorption speed, strong in adsorption force, and its external package has no carbon hair leaked, so that it can prevent the carbon hair from leaking and falling on the skin of patient to result in infection, and is an effective dressing capable of diminishing inflammation, stopping pain, promoting growth of tissue epithelial cell, accelerating wound healing and reducing scar. However, the edge fibers and the surface fibers are easy to fall off and can not prevent leakage, which is not beneficial to the long-time use of trauma patients.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the efficient absorption hemostatic dressing and the preparation method thereof, which have strong absorption and anti-extravasation functions and simultaneously have waterproof, breathable, antibacterial and hemostatic effects.
In order to achieve the purpose, the invention adopts the technical scheme that: the efficient absorption hemostatic dressing is characterized by sequentially comprising a hemostatic layer, an absorption core layer, an antibacterial layer, a waterproof layer and a bottom layer, wherein the raw materials for preparing the absorption core layer comprise fluff pulp and super absorbent resin.
The absorption core layer adopts an absorption structure combining the super absorbent resin and the fluff pulp, wherein the maximum water absorption capacity of the super absorbent resin can reach 347.7g/g, the super absorbent resin has a strong absorption function and can quickly absorb blood, the fluff pulp seals water, the combination can quickly and fully absorb the blood, the blood effectively coagulates without rewet, and the seepage prevention and leakage prevention are ensured.
In a preferred embodiment of the high-efficiency absorption hemostatic dressing, the mass ratio of the fluff pulp to the super absorbent resin is 1: 1. When the mass ratio of the fluff pulp to the super absorbent resin is 1:1, the saturated liquid absorption amount, the liquid retention amount, and the water absorption rate of the absorbent core layer are high.
In a preferred embodiment of the high-absorption hemostatic dressing of the present invention, the super absorbent resin is a polyacrylate super absorbent resin, and the synthetic raw material of the super absorbent resin is at least one of starch, cellulose, carboxylic acid, alkylene oxide, acrylic acid, and 2-acrylamide-2-methylpropanesulfonic acid.
As a preferable embodiment of the high-efficiency absorption hemostatic dressing, the raw materials for preparing the antibacterial layer comprise ethylene-vinyl acetate polymer and polystyrene, and a film formed by mixing the ethylene-vinyl acetate polymer and the polystyrene is in a net structure, has high water vapor transmission rate and can prevent bacteria from entering.
As a preferable embodiment of the high-efficiency absorption hemostatic dressing, the mass ratio of the ethylene-vinyl acetate polymer to the polystyrene is 50: 9.
As a preferable embodiment of the high-efficiency absorption hemostatic dressing, the antibacterial layer is a net structure.
As the preferred embodiment of the high-efficiency absorption hemostatic dressing, the preparation raw material of the hemostatic layer contains sodium alginate, and the sodium alginate has a good hemostatic function.
As a preferable embodiment of the high-efficiency absorption hemostatic dressing, the waterproof layer is a waterproof non-woven fabric, and the bottom layer is an elastic bandage.
As a preferable embodiment of the high-efficiency absorption hemostatic dressing, the hemostatic layer, the absorption core layer, the antibacterial layer and the waterproof layer have the same area and are smaller than the area of the bottom layer.
The invention also provides a preparation method of the efficient absorption hemostatic dressing, which comprises the following steps:
(1) preparing an antibacterial layer: weighing ethylene-vinyl acetate polymer and polystyrene according to a ratio, adding the ethylene-vinyl acetate polymer and an initiator accounting for 2 per mill of the total weight into a reaction vessel, heating to 70 ℃, then dropwise adding a styrene monomer to prepare a composite emulsion, and pouring the composite emulsion into a mold to form a film;
(2) preparing an absorption core layer: crushing a fluff pulp board into fluff pulp, uniformly mixing the fluff pulp with high water absorption resin with the same quality, demolding and molding, wrapping with wet strength paper, applying hot melt adhesive for bonding, compacting, cutting and preparing into an absorption core layer;
(3) preparing a hemostatic layer: weighing 3% of sodium alginate by mass, adding the sodium alginate into distilled water, uniformly stirring, standing for 36h, weighing membrane liquid, pouring the membrane liquid into a glass mold, drying and taking out the mold after the membrane liquid is naturally leveled, adding 5% of calcium chloride solution by mass after cooling, drying after crosslinking, and uncovering the membrane to obtain a sodium alginate membrane;
(4) preparing the efficient absorption hemostatic dressing: and compounding, compacting and cutting the elastic bandage, the waterproof non-woven fabric, the antibacterial layer, the absorption core layer and the hemostatic layer on line to prepare a finished product of the high-efficiency absorption hemostatic dressing.
Compared with the prior art, the invention has the beneficial effects that: the absorption core layer of the high-efficiency absorption hemostatic dressing adopts an absorption structure formed by combining the super absorbent resin and the fluff pulp, so that a large amount of blood is quickly and fully absorbed, the coagulation is effectively realized, the rewet is avoided, the seepage prevention and the leakage prevention are ensured, meanwhile, the high-efficiency absorption hemostatic dressing has waterproof, breathable, antibacterial and hemostatic effects, the wound surface is promoted to be quickly healed, and the high-efficiency absorption hemostatic dressing is widely suitable for patients with moderate and severe wounds.
In addition, the preparation process of the high-efficiency absorption hemostatic dressing is simple, the production cost is low, and the high-efficiency absorption hemostatic dressing is suitable for large-scale mass production.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
The dressing sequentially comprises a hemostatic layer, an absorption core layer, an antibacterial layer, a waterproof layer and a bottom layer, wherein the absorption core layer is composed of fluff pulp and high-water-absorptivity resin, the mass ratio of the fluff pulp to the high-water-absorptivity resin is 1:1, the high-water-absorptivity resin is polyacrylate high-water-absorptivity resin, the antibacterial layer is a net-shaped structure film formed by mixing ethylene-vinyl acetate polymer and polystyrene with the mass ratio of 50:9, the hemostatic layer is composed of a sodium alginate film, the waterproof layer is waterproof non-woven fabric, the bottom layer is an elastic bandage, and the areas of the hemostatic layer, the absorption core layer, the antibacterial layer and the waterproof layer are equal and smaller than the area of the bottom layer.
A preparation method of a high-efficiency absorption hemostatic dressing comprises the following specific steps:
(1) preparing an antibacterial layer: adding 100g of ethylene-vinyl acetate polymer and 0.2g of initiator dibenzoyl peroxide (BPO) to a 500ml four-opening beaker provided with a stirrer, a thermometer, a condenser tube and a pressure-stabilizing dropping funnel, heating to 70 ℃, then dropwise adding 18g of styrene monomer subjected to reduced pressure distillation for about 2 hours, then continuously reacting for 2-3 hours to prepare a composite emulsion, and pouring the composite emulsion into a mold to form a film at about 15 ℃;
(2) preparing an absorption core layer: crushing the fluff pulp board into fluff pulp in a wood pulp crusher, placing the fluff pulp board and high-water-absorption resin with the same quality in a forming drum, uniformly mixing, demolding, forming, wrapping with wet strength paper, applying hot melt adhesive for bonding (the temperature of the hot melt adhesive is 130-150 ℃), compacting by a double smooth roller (the temperature of the roller is 110-130 ℃), and cutting to prepare an absorption core layer;
(3) preparing a hemostatic layer: weighing 3% of sodium alginate by mass, adding the sodium alginate into heated distilled water, uniformly stirring, pouring the mixed membrane liquid into a beaker, sealing the cup mouth with a plastic membrane, standing for 36h to remove bubbles in the membrane, weighing 30ml of the membrane liquid, pouring the membrane liquid into a 15 cm-by-10 cm glass mold, naturally leveling the membrane liquid, putting the mold into an oven, drying at 70 ℃, taking out the mold after drying, cooling, adding 5% of calcium chloride solution by mass, crosslinking for 5min, then drying the crosslinked membrane, and uncovering the membrane to obtain a sodium alginate membrane;
(4) preparing the efficient absorption hemostatic dressing: and compounding, compacting and cutting the elastic bandage, the waterproof non-woven fabric, the antibacterial layer, the absorption core layer and the hemostatic layer on line to prepare a finished product of the high-efficiency absorption hemostatic dressing.
Experimental example 1
The water absorption rate, liquid retention capacity and moisture permeability of the high-efficiency absorption hemostatic dressing example 1 and the common activated carbon fiber absorption core layer provided by the invention were measured according to the following test methods, the tests were respectively carried out for 3 times and the average value was taken, and the test results are shown in table 1.
Water absorption rate:
approximately 10ml of physiological saline (0.9% NaCl) was put into a stainless steel container, and the test material was cut into 4 × 4cm test pieces, which were sealed in the container and stored for 8 hours, wherein the weight of the test piece before the container was put was m1(g), the weight of the test piece taken out after 8 hours was m2(g), and the water absorption capacity Q was (m2-m1)/m 1.
Water absorption rate:
500. mu.l of physiological saline (0.9% NaCl) was dropped onto the surface of the test piece, and the time during which the liquid was completely absorbed was measured.
Liquid retention capacity:
the test material was cut into test pieces of 7cm by 10cm by 0.1cm by placing physiological saline (0.9% NaCl) of L1(ml) in a stainless steel container, the test pieces were sealed in the container and stored for 8 hours, and after the test pieces were taken out, the amount of remaining physiological saline L2(ml) was measured, and the retention capacity was (L2-L1)/(7 by 10.1) 103(L/m3)。
Moisture permeability:
measurements were made according to the cup method of GB 1037-88. About 10ml of distilled water was put into a glass container, a test material was cut into a circular test piece having a diameter of 80mm, the open part of the glass container was covered with the test piece, the glass container was sealed with a paraffin-made film, and the weight W0 at this time was measured. Then, after standing in a 40-75% constant temperature and humidity apparatus for 24 hours, the weight W1 after cooling was accurately measured, and the moisture permeability was (W1-W0) × 104/A(g/m2/24h), wherein A is the area (cm) of the opening of the glass container2)。
TABLE 1 test results
As can be seen from table 1, the absorbent core layer of the high-efficiency absorbent hemostatic dressing of the present invention contains fluff pulp and super absorbent resin, and has higher water absorption capacity, strong liquid retention capacity and high moisture permeability than the common absorbent core layer of activated carbon fiber. The invention adopts the absorption structure of the combination of the super absorbent resin and the fluff pulp, can absorb quickly and fully, effectively agglomerate without rewet, ensure seepage prevention and leakage prevention, and have better liquid retention capacity and moisture permeability.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. The efficient absorption hemostatic dressing is characterized by sequentially comprising a hemostatic layer, an absorption core layer, an antibacterial layer, a waterproof layer and a bottom layer;
the preparation method of the high-efficiency absorption hemostatic dressing comprises the following steps:
(1) preparing an antibacterial layer: weighing ethylene-vinyl acetate polymer and polystyrene according to a ratio, adding the ethylene-vinyl acetate polymer and an initiator accounting for 2 per mill of the total weight into a reaction vessel, heating to 70 ℃, then dropwise adding a styrene monomer to prepare a composite emulsion, and pouring the composite emulsion into a mold to form a film; the mass ratio of the ethylene-vinyl acetate polymer to the polystyrene is 50: 9;
(2) preparing an absorption core layer: crushing a fluff pulp board into fluff pulp, uniformly mixing the fluff pulp with high water absorption resin with the same quality, demolding and molding, wrapping with wet strength paper, applying hot melt adhesive for bonding, compacting, cutting and preparing into an absorption core layer;
(3) preparing a hemostatic layer: weighing 3% of sodium alginate by mass, adding the sodium alginate into distilled water, uniformly stirring, standing for 36h, weighing membrane liquid, pouring the membrane liquid into a glass mold, drying and taking out the mold after the membrane liquid is naturally leveled, adding 5% of calcium chloride solution by mass after cooling, drying after crosslinking, and uncovering the membrane to obtain a sodium alginate membrane;
(4) preparing the efficient absorption hemostatic dressing: and compounding, compacting and cutting the elastic bandage, the waterproof non-woven fabric, the antibacterial layer, the absorption core layer and the hemostatic layer on line to prepare a finished product of the high-efficiency absorption hemostatic dressing.
2. The dressing as claimed in claim 1, wherein the super absorbent resin is polyacrylate type super absorbent resin, and the synthetic raw material of the super absorbent resin is at least one of starch, cellulose, carboxylic acid, alkylene oxide, acrylic acid, and 2-acrylamide-2-methylpropanesulfonic acid.
3. The high absorption hemostatic dressing according to claim 1, wherein the antimicrobial layer is a mesh structure.
4. The high absorption hemostatic dressing according to claim 1, wherein the waterproof layer is a waterproof nonwoven fabric and the bottom layer is an elastic bandage.
5. The high efficiency absorbent hemostatic dressing of claim 1, wherein the hemostatic layer, absorbent core layer, antimicrobial layer, and waterproof layer are of equal area and less than the area of the bottom layer.
6. The method for preparing a high efficiency absorptive hemostatic dressing according to any one of claims 1 to 5, comprising the steps of:
(1) preparing an antibacterial layer: weighing ethylene-vinyl acetate polymer and polystyrene according to a ratio, adding the ethylene-vinyl acetate polymer and an initiator accounting for 2 per mill of the total weight into a reaction vessel, heating to 70 ℃, then dropwise adding a styrene monomer to prepare a composite emulsion, and pouring the composite emulsion into a mold to form a film;
(2) preparing an absorption core layer: crushing a fluff pulp board into fluff pulp, uniformly mixing the fluff pulp with high water absorption resin with the same quality, demolding and molding, wrapping with wet strength paper, applying hot melt adhesive for bonding, compacting, cutting and preparing into an absorption core layer;
(3) preparing a hemostatic layer: weighing 3% of sodium alginate by mass, adding the sodium alginate into distilled water, uniformly stirring, standing for 36h, weighing membrane liquid, pouring the membrane liquid into a glass mold, drying and taking out the mold after the membrane liquid is naturally leveled, adding 5% of calcium chloride solution by mass after cooling, drying after crosslinking, and uncovering the membrane to obtain a sodium alginate membrane;
(4) preparing the efficient absorption hemostatic dressing: and compounding, compacting and cutting the elastic bandage, the waterproof non-woven fabric, the antibacterial layer, the absorption core layer and the hemostatic layer on line to prepare a finished product of the high-efficiency absorption hemostatic dressing.
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| CN112266455B (en) * | 2020-09-29 | 2022-07-12 | 万华化学集团股份有限公司 | Modified high blood-absorption polyurethane sponge, preparation method and application thereof |
| CN113997646A (en) * | 2021-11-15 | 2022-02-01 | 无锡优佳无纺科技有限公司 | Non-woven fabrics absorbs water fast |
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