CN109222905A - Encephalic wound healing monitoring device, preparation method and application - Google Patents
Encephalic wound healing monitoring device, preparation method and application Download PDFInfo
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- CN109222905A CN109222905A CN201811018104.XA CN201811018104A CN109222905A CN 109222905 A CN109222905 A CN 109222905A CN 201811018104 A CN201811018104 A CN 201811018104A CN 109222905 A CN109222905 A CN 109222905A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000012806 monitoring device Methods 0.000 title claims abstract description 6
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- 229910001338 liquidmetal Inorganic materials 0.000 claims abstract description 23
- 238000012544 monitoring process Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims description 16
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 15
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 15
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 15
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 15
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 15
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims description 10
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- 229910000807 Ga alloy Inorganic materials 0.000 claims description 5
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- 229920005839 ecoflex® Polymers 0.000 claims description 2
- 239000002923 metal particle Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
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- 229940127554 medical product Drugs 0.000 claims 1
- 206010052428 Wound Diseases 0.000 abstract description 18
- 208000027418 Wounds and injury Diseases 0.000 abstract description 18
- 210000004556 brain Anatomy 0.000 abstract description 18
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- 239000008280 blood Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M1/00—Inking and printing with a printer's forme
- B41M1/12—Stencil printing; Silk-screen printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
It include: flexible electrode array and photoacoustic imaging system the present invention provides a kind of encephalic wound healing monitoring device, preparation method and application, described device.Flexible electrode array based on liquid metal has lower elasticity modulus, can be closely adhered on thickness wound surface, detect high-resolution EEG signals while with high biological safety；Not only detection accuracy is high for photoacoustic imaging system, not damaged to organizing, and safe ready, is the important advance of medical imaging auxiliary diagnosis；In conjunction with flexible brain electrode array and photoacoustic imaging system, the problem that encephalic wound can not be observed is overcome, realizes the non-invasive monitoring of encephalic wound, monitoring precision even can satisfy clinical monitoring index request.
Description
Technical field
The invention belongs to encephalic wounds to monitor field, and in particular to a kind of encephalic wound healing monitoring device, its preparation side
Method and application.
Background technique
Effective monitoring means is lacked for cranial traumas situation at present, is a great problem of clinical treatment.In time, accurately
Ground monitors encephalic wound healing situation, not only contributes to the variation of early detection encephalic wound, improves therapeutic effect, and for facing
Bed diagnosis and guiding treatment have very important significance.Implanted brain electrode can effectively monitor brain tissue electric signal, thus
The healing state of wound can be judged according to the variation of EEG signals.Wherein brain electrode array is the important brain for monitoring EEG signals
Machine interface can establish direct communication channel between human brain and electronic equipment, important number is provided for wound healing situation
According to reference.Although being easy to cause one to tissue however, traditional embedded nerve electrode can obtain higher signal-to-noise ratio
Fixed damage, such as commercial Michigan electrode and Utah electrode.In recent years, novel flexible brain electrode array is with its high score
The signal detection and extremely low tissue damage distinguished have become the emphasis of neuroscience field research.
At the same time, with the continuous development of medical imaging technology, medical imaging technology provides for the monitoring of encephalic wound
Strong technical support.Common medical imaging technology includes nmr imaging technique (MRI), X ray computer tomography
Scanning technique (CT) and photoacoustic imaging technology (PAT).In actual use, MRI imaging is needed by means of powerful magnetic field,
And the time for generating image is longer, cannot achieve the real time imagery to tissue wounds；CT imaging generates a large amount of when in use
Radiation is not useable for observing for a long time.As a kind of emerging non-intrusion type imaging technique, photoacoustic imaging technology combines optics
The advantages of imaging and ultrasonic imaging, the good characteristic with high contrast and high-penetration depth can provide clear duration
Monitoring imaging.
Therefore, in conjunction with flexible brain electrode array and photoacoustic imaging technology, seeking to develop one kind can be hurt with accurate measurements encephalic
The method of mouth healing situation has good research and application value.
Summary of the invention
Therefore, the purpose of the present invention is to overcome the defects in the prior art, provides a kind of encephalic wound healing monitoring dress
It sets, preparation method and application.
Before illustrating the content of present invention, it is as follows to define term used herein:
Term " PDMS " refers to: dimethyl silicone polymer.
To achieve the above object, the first aspect of the present invention provides a kind of encephalic wound healing monitoring device, the dress
Set includes: flexible electrode array and photoacoustic imaging system.
Device according to a first aspect of the present invention, wherein the photoacoustic imaging system is near infrared light acoustic imaging system；It is excellent
Selection of land, the photoacoustic imaging system include pulse laser, ultrasound signal receipt device and data processing analysis module.
Device according to a first aspect of the present invention, wherein the flexible electrode array includes: substrate, and in the substrate
Conducting wire is interconnected made of upper nanoscale or the convergence of micron order liquid metal particle.
Device according to a first aspect of the present invention, wherein the base material is selected from one or more of: PDMS,
The high molecular materials such as Ecoflex, soluble polyurethane, polylactic acid, polycaprolactone；Preferably PDMS.
Device according to a first aspect of the present invention, wherein the liquid metal is selected from one or more of: indium gallium closes
Gold, gallium-indium-tin alloy, bismuth tin alloy；Preferably indium gallium alloy.
Device according to a first aspect of the present invention, wherein the preparation method of the flexible electrode array the following steps are included:
(1) liquid metal is added in organic solvent, liquid metal is processed into micro-nano granules, obtains liquid metal
Ink；
(2) electrod-array pattern is drawn with liquid metal ink prepared by step (1)；
(3) after solvent volatilization completely, the base material for precuring of casting on the electrode pattern of printing, completion of cure
Afterwards, flexible electrode array is obtained.
Preferably, in the step (1), the organic solvent is selected from one or more of: Decanol, water, alcohol, third
Ketone, N,N-dimethylformamide, methylene chloride, chloroform, tetrahydrofuran；Preferably Decanol.
In the step (1), the processing method is ultrasound and/or mechanical stirring.
In the step (2), the electrod-array pattern method for drafting is selected from one or more of: silk-screen printing, spray
Ink printing, 3D printing；Preferably silk-screen printing.
The second aspect of the present invention provides device described in first aspect and is preparing the medical treatment for monitoring wound healing
Application in product.
The object of the present invention is to overcome the problems of the prior art, is unable to monitor for encephalic wound healing situation
Severe challenge provides a kind of method that can monitor encephalic wound healing situation, and it is real that encephalic wound situation may be implemented in this method
When accurate measurements, for cranial traumas diagnosis reference is provided, have great clinical meaning and application value.
To achieve the goals above, the present invention is realized using following technical scheme:
Using the EEG signals of the brain electrode array detection encephalic wound tissue of flexible extensible, in conjunction with photoacoustic imaging skill
Art obtains the full resolution pricture of wound tissue, so as to real-time and accurately monitor wound healing situation.
The brain electrode array of flexible extensible of the present invention is using the liquid metal of high biological safety as conductive
Matrix, and screen printing technique is used, it prepares biological with the high stretch and height that dimethyl silicone polymer (PDMS) is substrate
The brain electrode array of safety.Compared with traditional gold, silver and conducting polymer, liquid metal not only has excellent stretching
Performance, and show good biological safety.Flexible brain electrode array the specific process steps are as follows:
(1) liquid metal is added in organic solvent, under the action of ultrasound or mechanical stirring, liquid metal is processed
At micro-nano granules.
(2) silk-screen printing technique is used, liquid metal electrically conductive ink is printed as to the brain electrode array pattern being pre-designed.
(3) after solvent volatilization completely, the PDMS for precuring of casting on the electrode pattern of printing, and then completion of cure
Afterwards, the brain electrode array of flexible extensible can be obtained.
Photoacoustic imaging system of the present invention is commercial near infrared light acoustic imaging system, mainly includes pulse laser
Device, ultrasound signal receipt device and Data Management Analysis module can carry out high-resolution and high-contrast image, while right
Blood vessel and blood oxygen saturation in wound carry out clearly dynamic monitoring.
Compared with prior art, the present invention can have but be not limited to it is following the utility model has the advantages that
(1) the flexible extensible brain electrode array based on liquid metal has lower while with high biological safety
Elasticity modulus, can be closely adhered on thickness wound surface, detect high-resolution EEG signals.
(2) not only detection accuracy is high for photoacoustic imaging system, not damaged to organizing, and safe ready, is that medical imaging is auxiliary
Help the important advance of diagnosis.
(3) flexible brain electrode array and photoacoustic imaging system are combined, the problem that encephalic wound can not be observed is overcome, is realized
The non-invasive monitoring of encephalic wound, monitoring precision even can satisfy clinical monitoring index request.
Detailed description of the invention
Hereinafter, carrying out the embodiment that the present invention will be described in detail in conjunction with attached drawing, in which:
Fig. 1 shows the flexible brain electrode array schematic diagram based on liquid metal that the present invention uses.
Fig. 2 shows Hippocampal cells cultivated 10 days on liquid metal electrode after confocal laser scanning microscope
Shape appearance figure.
Specific embodiment
Present invention will be further explained by specific examples below, it should be understood, however, that, these embodiments are only
It is used, is but should not be understood as present invention is limited in any form for specifically describing in more detail.
This part carries out general description to the material and test method that arrive used in present invention test.Although being
It realizes many materials used in the object of the invention and operating method is it is known in the art that still the present invention still uses up herein
It may detailed description.It will be apparent to those skilled in the art that within a context, if not specified, material therefor of the present invention and behaviour
It is well known in the art as method.
Reagent and instrument used in the following embodiment are as follows:
Reagent:
Indium gallium alloy is purchased from Dow Corning purchased from Sigma Aldrich, Decanol, PDMS (Sylgard 184)
Company.
Instrument:
Ultrasonic cell disruption instrument is purchased from Branson Ultrasonics Corp., model S-450D；
Photoacoustic imaging system is purchased from VisualSonics company of Canada, model Vevo LAZR.
Embodiment 1
The present embodiment is used to illustrate the preparation for processing of flexible brain electrode array of the invention, comprising the following steps:
By 4 grams of liquid metals (indium gallium alloy, gallium mass fraction 75.5%, indium mass fraction 24.5%) and 1 milliliter of positive last of the ten Heavenly stems
Alcohol is added in 5 milliliters of centrifuge tubes.Ultrasonic cell disruption instrument ultrasound 2 minutes under 20% intensity can prepare liquid gold
Belong to micro-nano granules, the liquid metal ink of preparation is added on screen printing template, printing obtains the pattern of electrod-array.It connects
Get off, the PDMS (PDMS: curing agent=10:1) of precuring is cast on electrod-array pattern, electrode is put into 80 degrees Celsius
Oven for curing 2 hours, to PDMS after curing completely, flexible brain electrode array can be obtained by taking PDMS off from substrate.It will
PDMS is poured on the pet substrate, and after curing completely takes PDMS from substrate off, and the substrate of obtained electrod-array is PDMS.
Embodiment 2
This test example is used to illustrate that flexible electrode array combination photoacoustic imaging system to monitor encephalic wound situation, including following
Step:
Using rat as experimental subjects, the brain tissue wound of rat specific region is monitored.After rat anesthesia, in the top of the skull
The opening of 2 centimetres of 2 cm x is manufactured on bone, after removing endocranium, surface layer thoroughly exposes, flexibility prepared by embodiment 1
Electrode is fitted on cerebral cortex, and flexible electrode is connect with commercialization EEG system, monitors the EEG signals variation in the region.With this
Meanwhile real-time accurate imaging is carried out to monitoring position using photoacoustic imaging system, photoacoustic imaging system alignment probe brain tissue
Intermediate region, the EEG signals of electrod-array detection periphery, photoacoustic imaging system carry out real time imagery to brain tissue wound.Pass through
Comparison EEG signals and photoacoustic image judge the traumatic event of brain tissue.
Although present invention has been a degree of descriptions, it will be apparent that, do not departing from the spirit and scope of the present invention
Under the conditions of, the appropriate variation of each condition can be carried out.It is appreciated that the present invention is not limited to the embodiments, and it is attributed to right
It is required that range comprising the equivalent replacement of each factor.
Claims (10)
1. a kind of encephalic wound healing monitoring device, which is characterized in that described device includes: flexible electrode array and photoacoustic imaging
System.
2. the apparatus according to claim 1, which is characterized in that the photoacoustic imaging system is near infrared light acoustic imaging system
System；Preferably, the photoacoustic imaging system includes pulse laser, ultrasound signal receipt device and data processing analysis module.
3. device according to claim 1 or 2, which is characterized in that the flexible electrode array includes: substrate, and in institute
It states and interconnects conducting wire made of nanoscale or the convergence of micron order liquid metal particle in substrate.
4. device according to claim 3, which is characterized in that the base material is selected from one or more of: PDMS,
The high molecular materials such as Ecoflex, soluble polyurethane, polylactic acid, polycaprolactone；Preferably PDMS.
5. device according to claim 3 or 4, which is characterized in that the liquid metal is selected from one or more of: indium
Gallium alloy, gallium-indium-tin alloy, bismuth tin alloy；Preferably indium gallium alloy.
6. device according to any one of claim 1 to 5, which is characterized in that the preparation side of the flexible electrode array
Method the following steps are included:
(1) liquid metal is added in organic solvent, liquid metal is processed into micro-nano granules, obtain liquid metal oil
Ink；
(2) electrod-array pattern is drawn with liquid metal ink prepared by step (1)；
(3) after solvent volatilization completely, the base material for precuring of casting on the electrode pattern of printing, after curing completely,
Obtain flexible electrode array.
7. according to the method described in claim 6, it is characterized in that, the organic solvent is selected from next in the step (1)
Kind is a variety of: Decanol, water, alcohol, acetone, N,N-dimethylformamide, methylene chloride, chloroform, tetrahydrofuran；It is preferred that
For Decanol.
8. method according to claim 6 or 7, which is characterized in that in the step (1), the processing method is ultrasound
And/or mechanical stirring.
9. the method according to any one of claim 6 to 8, which is characterized in that in the step (2), the electrode array
Column pattern method for drafting is selected from one or more of: silk-screen printing, inkjet printing, 3D printing；Preferably silk-screen printing.
10. any one of claims 1 to 5 described device is preparing the application in the medical product for monitoring wound healing.
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| CN201811018104.XA CN109222905B (en) | 2018-09-03 | 2018-09-03 | Intracranial wound healing monitoring device, preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811018104.XA CN109222905B (en) | 2018-09-03 | 2018-09-03 | Intracranial wound healing monitoring device, preparation method and application thereof |
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| CN109222905A true CN109222905A (en) | 2019-01-18 |
| CN109222905B CN109222905B (en) | 2021-09-10 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251125A (en) * | 2019-07-12 | 2019-09-20 | 南方科技大学 | A kind of flexible extensible nerve electrode and its preparation method and application |
| CN112120696A (en) * | 2020-09-29 | 2020-12-25 | 中国科学院上海微系统与信息技术研究所 | Method for implanting deep flexible brain electrode combined with drug delivery |
| CN112530626A (en) * | 2020-12-04 | 2021-03-19 | 南方科技大学 | Degradable flexible lead and preparation method and application thereof |
| CN112535531A (en) * | 2020-11-27 | 2021-03-23 | 广东省医疗器械研究所 | Method and device for detecting welding effect of biological tissue |
| CN114010163A (en) * | 2021-12-02 | 2022-02-08 | 中国中医科学院医学实验中心 | Epidermal cell migration positioning system and method based on optical imaging |
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