CN109044411B - Tear detection contact lens based on capillary force driving - Google Patents

Tear detection contact lens based on capillary force driving Download PDF

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CN109044411B
CN109044411B CN201811038240.5A CN201811038240A CN109044411B CN 109044411 B CN109044411 B CN 109044411B CN 201811038240 A CN201811038240 A CN 201811038240A CN 109044411 B CN109044411 B CN 109044411B
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flow channel
tear
cavity
contact lens
outlet
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CN109044411A (en
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弥胜利
杨星
赵港南
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Shenzhen Graduate School Tsinghua University
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Shenzhen Graduate School Tsinghua University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0067—Tear or lachrymal fluid

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Pathology (AREA)
  • Eye Examination Apparatus (AREA)
  • Eyeglasses (AREA)

Abstract

A tear detection contact lens based on capillary force driving comprises an inner layer and an outer layer, wherein the inner layer is in contact with a cornea, the outer layer is in contact with an eyelid, a flow channel for tear component detection and a cavity for discharging tears from the flow channel are arranged on the inner layer, the flow channel comprises a tear inlet and a tear outlet, the flow channel drives tears to flow from the tear inlet to the tear outlet by means of capillary action, the cavity is connected with the flow channel at the tear outlet and forms a certain included angle with the flow channel, a cavity membrane corresponding to the cavity is arranged on the outer layer, the cavity membrane and the cavity form a cavity, and the cavity membrane is squeezed by means of blinking of a wearer to change the volume of the cavity, so that pressure is generated, and tears at the tear outlet are discharged from the flow channel. The contact lens drives tears to flow into the flow channel by capillary force, and can generate color reaction with color substance in the flow channel, so as to realize the detection of specific components in tears, and can be used for diagnosis of related diseases.

Description

Tear detection contact lens based on capillary force driving
Technical Field
The invention relates to a tear detection contact lens based on capillary force driving.
Background
The human tears contain a plurality of components, and the occurrence of some diseases can influence the change of the tear component concentration, and researches show that the reliable analysis of the tear component can provide a favorable basis for the diagnosis of related diseases. At present, the popular way of detecting the tear components is to collect tears through an in-vitro device and then carry out related detection, and the defects of complex steps, low detection sensitivity and the like exist in the existing mode.
Disclosure of Invention
It is a primary object of the present invention to overcome the disadvantages of the prior art and to provide a tear detecting contact lens based on capillary force actuation.
In order to achieve the purpose, the invention adopts the following technical scheme:
a tear detection contact lens based on capillary force driving comprises an inner layer and an outer layer, wherein the inner layer is in contact with a cornea, the outer layer is in contact with an eyelid, a flow channel for tear component detection and a cavity for discharging tears from the flow channel are arranged on the inner layer, the flow channel comprises a tear inlet and a tear outlet, the flow channel drives tears to flow from the tear inlet to the tear outlet by means of capillary action, the cavity is connected with the flow channel at the tear outlet and forms a certain included angle with the flow channel, a cavity membrane corresponding to the cavity is arranged on the outer layer, the cavity membrane and the cavity form a cavity, and the cavity membrane is squeezed by means of blinking of a wearer to change the volume of the cavity, so that pressure is generated, and tears at the tear outlet are discharged from the flow channel.
One or more chromogenic substances are embedded in the flow channel, when the tear flows in the flow channel, a specific component in the tear and the chromogenic substances perform a specific chromogenic reaction, so that the concentration of the component in the tear is detected by utilizing the shade of the reaction color.
The inner layer and the outer layer are the same in shape and the radian is matched with the shape of the eyes.
The flow channel comprises a plurality of parallel tear inlets and a tear outlet.
The flow passage comprises a main body flow passage with a square section, a small flow passage with a square section exists in the flow passage, the sectional dimension of the small flow passage is smaller than that of the main body flow passage, and the small flow passage is used for preventing the lacrimal fluid from reversely flowing from the lacrimal fluid outlet to the lacrimal fluid inlet, and preferably, the small flow passage is arranged behind the connecting point of the cavity and the flow passage close to the lacrimal fluid outlet.
The side length of the section of the main body runner is 0.3mm, and the side length of the section of the small runner is 0.2 mm.
The cavity is connected with the flow channel through a section of micro-channel with the section changing from large to small.
There is gradient change in the size of cross-section, preferably, the microchannel include with the runner be the first bench of first contained angle and with the runner is the second bench of second contained angle, first contained angle is greater than the second contained angle, just the gradient change of second bench is compared the gradient change of first bench is more urgent.
The inner layer comprises a plurality of microstructures, the microstructures are distributed on the inner layer at equal intervals along the circumference, each microstructure is provided with a flow channel and a cavity, the outer layer comprises a plurality of cavity films, and the cavity films correspond to the cavities on the microstructures one to one.
3 of said microstructures are equally spaced on said inner layer.
The invention has the following beneficial effects:
the invention provides a tear detection contact lens based on capillary force driving, and tear flows in a flow channel under the driving of the capillary force under the condition of not implanting any power. At the tear outlet, the cavity membrane is pressed by blinking action of the wearer to change the volume of the cavity, so as to generate pressure and discharge the tear at the tear outlet out of the flow passage. The tear detecting contact lens achieves the collection of tears in a simple and effective manner.
In a preferred embodiment, a specific chromogenic substance is further embedded in the flow channel, and when the tear flows in the flow channel, a specific chromogenic reaction occurs with the chromogenic substance, the shade of the color reflects the concentration of the specific tear component, so that the detection of the specific tear component provides a basis for diagnosis of related diseases, and the detection sensitivity is high, and the implementation is simple.
The contact lens of the preferred embodiment of the invention automatically drives the tears to flow into the flow channel through capillary force, and generates color reaction with the embedded substance in the flow channel, realizes the detection of specific components in the tears, can be effectively used for the diagnosis of related diseases, and provides a simple, convenient and effective solution for the detection of the tear components.
Drawings
Fig. 1 is a schematic structural view of a tear detecting contact lens according to an embodiment of the present invention.
FIG. 2 is a diagram of the structure of the inner layer of a contact lens according to an embodiment.
Fig. 3 is a diagram of the structure of the outer layer of a contact lens according to one embodiment.
Fig. 4 is an enlarged view of the tear outlet and cavity structure of one embodiment of a contact lens.
Reference numbers in the figures:
10-inner layer, 11-tear inlet, 12-flow channel, 13-cavity, 14-tear outlet, 20-outer layer, 21-cavity membrane
Detailed Description
The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
Referring to fig. 1 to 4, in one embodiment, a capillary force driven tear detection contact lens comprises an inner layer 10 for contacting with a cornea and an outer layer 20 for contacting with an eyelid, the inner layer 10 is provided with a flow channel 12 for tear component detection and a cavity 13 for discharging tear out of the flow channel 12, the flow channel 12 comprises a tear inlet 11 and a tear outlet 14, the flow channel 12 self-drives tear to flow from the tear inlet 11 to the tear outlet 14 by capillary action, the cavity 13 is connected with the flow channel 12 at the tear outlet 14 and forms an included angle with the flow channel 12, the outer layer 20 is provided with a cavity membrane 21 corresponding to the cavity 13, the cavity membrane 21 and the cavity 13 form a cavity, and the cavity membrane 21 is pressed by a blinking motion of a wearer to change the volume of the cavity, pressure is generated to expel the tear fluid from the tear outlet out of the flow channel 12.
In a preferred embodiment, the cavity 13 is connected to the flow channel 12 by a section of micro-channel with a cross-section that varies from large to small.
In a more preferred embodiment, there is a gradient in the size of the cross-section. In a particularly preferred embodiment, the microchannel comprises a first step having a first included angle with the flow channel 12 and a second step having a second included angle with the flow channel 12, the first included angle is greater than the second included angle, and the gradient change of the second step is more acute than the gradient change of the first step. In a preferred embodiment as shown in fig. 4, the first ladder section has a parallelogram shape in projection and the second ladder section has a trapezoid shape in projection.
In a preferred embodiment, the flow channel 12 comprises a main flow channel 12 with a square cross section, and a small flow channel 12 with a square cross section is present in the flow channel 12, the small flow channel 12 has a smaller cross section than the main flow channel 12 for preventing the reverse flow of tear liquid from the tear liquid outlet 14 to the tear liquid inlet 11, and preferably, the small flow channel 12 is disposed close to the tear liquid outlet 14 and behind the connection point of the cavity 13 and the flow channel 12.
In a more preferred embodiment, the side length of the cross section of the main body flow passage 12 is 0.3mm, and the side length of the cross section of the small flow passage 12 is 0.2 mm.
In a preferred embodiment, the inner layer 10 and the outer layer 20 are the same shape and arc matched to the shape of the eye.
In the preferred embodiment, the flow channel 12 comprises a plurality of tear inlets 11 and a tear outlet 14 connected in parallel.
In a preferred embodiment, the inner layer 10 includes a plurality of microstructures, the microstructures are distributed on the inner layer 10 at equal intervals along the circumference, each microstructure is formed with the flow channel 12 and the cavity 13, the outer layer 20 includes a plurality of cavity films 21, and the cavity films 21 correspond to the cavities 13 on the microstructures one to one.
In a preferred embodiment, 3 microstructures are equally spaced on the inner layer 10.
In a preferred embodiment, one or more chromogenic substances are embedded in the flow channel 12, and when the tear flows in the flow channel 12, a specific component in the tear and the chromogenic substance perform a specific chromogenic reaction, so that the concentration of the component in the tear is detected by using the shade of the reaction color.
The features and operation of embodiments of the present invention are further described below in conjunction with the following figures.
Referring to fig. 1 to 4, the contact lens is composed of an inner layer 10 and an outer layer 20, and the inner layer 10 and the outer layer 20 are treated for 30 seconds by a plasma cleaner and then bonded to form a single body. The inner layer 10 has a flow channel 12 for detecting a tear component and a cavity 13, and the outer layer 20 has a convex cavity membrane 21.
The flow channel 12 comprises two parallel tear inlets 11 and a tear outlet 14, tear enters the flow channel 12 from any tear inlet 11 under the drive of capillary force and is conveyed to the tear outlet 14, and due to the existence of liquid surface tension, the tear stays at the tear outlet 14 and stops moving. In this process, the flow of tear liquid in the flow channel 12 is driven entirely by capillary force without providing an additional power source.
The cavity 13 and the cavity membrane 21 form a chamber, and when the wearer blinks, the cavity membrane 21 is pressed, the volume of the chamber changes, pressure is generated, and the tear stays in the tear outlet 14 and is discharged out of the flow channel 12.
The specific substance for developing color is embedded in the flow channel 12, when the tear flows in the flow channel 12, the specific component in the tear and the color developing substance generate specific color developing reaction, and the depth of the reaction color indicates the concentration of the component in the tear.
The flow channel 12 has a narrow flow channel having a square cross section with a side length of 0.2mm, and the difference in cross section causes different resistance at both ends, thereby preventing the reverse flow of tear fluid at the tear outlet 14.
The cavity 13 is connected in parallel with the flow channel 12 through a section of micro-channel with gradient of section varying from large to small and forms a certain included angle, so that the capillary force in the flow channel 12 is not influenced by the cavity 13, and the pressure of the cavity 13 can successfully discharge tears at the tears outlet 14.
As shown in figure 1, the multi-region tear detecting contact lens based on capillary force drive is composed of an inner layer 10 and an outer layer 20, wherein the inner layer 10 is in contact with the cornea of the eye, tear enters from a tear inlet 11 by virtue of capillary force, the tear flows in a flow channel 12 under the drive of the capillary force and undergoes chromogenic reaction with a chromogenic substance embedded in the flow channel 12, the shade of the color represents the concentration of a specific component of the tear, and finally, the tear flows out from a tear outlet 14 under the pressure of a cavity 13. The outer layer 20 is provided with cavity membranes 21, and the cavity membranes 21 correspond to the cavities 13 one by one to form a cavity together.
Fig. 2 shows a specific microstructure of the inner layer 10, wherein 3 microstructures are distributed at equal intervals along the circumference, so that the detection of multiple regions of different components can be realized. The microstructure comprises a tear inlet 11, a flow channel 12, a tear outlet 14, and a cavity 13. These structures are connected together in series and parallel to form an open system in which tears circulate.
Fig. 3 shows a specific structure of the outer layer 20, which includes 3 convex cavity membranes 21 in one-to-one correspondence with the cavities 13. The raised cavity membrane 21 and the cavity 13 form a cavity, which converts the pressure.
Fig. 4 shows an enlarged view of the structure of the tear outlet 14 and the cavity 13. The cavity 13 is connected in parallel with the flow channel 12 through a section of micro-channel with gradient of section changing from large to small and forms a certain included angle. There is a narrow flow passage of reduced cross-sectional dimension in the flow passage 12 for preventing the reverse flow of tear fluid at the tear outlet 14 by virtue of the change in cross-sectional dimension.
The foregoing is a more detailed description of the invention in connection with specific/preferred embodiments and is not intended to limit the practice of the invention to those descriptions. It will be apparent to those skilled in the art that various substitutions and modifications can be made to the described embodiments without departing from the spirit of the invention, and these substitutions and modifications should be considered to fall within the scope of the invention.

Claims (10)

1. A tear detection contact lens based on capillary force driving is characterized by comprising an inner layer and an outer layer, wherein the inner layer is in contact with a cornea, the outer layer is in contact with an eyelid, a flow channel for tear component detection and a cavity for discharging tears out of the flow channel are arranged on the inner layer, the flow channel comprises a tear inlet and a tear outlet, the flow channel drives tears to flow from the tear inlet to the tear outlet by means of capillary action, the cavity is connected with the flow channel at the tear outlet and forms a certain included angle with the flow channel, the cavity is connected with the flow channel through a micro-channel with a section of which the cross section changes from large to small, a cavity membrane corresponding to the cavity is arranged on the outer layer, the cavity membrane and the cavity form a cavity, the cavity membrane is squeezed by means of blinking of a wearer to change the volume of the cavity, and pressure is generated, a tear discharge channel for discharging the tear outlet; one or more chromogenic substances are embedded in the flow channel, when the tear flows in the flow channel, a specific component in the tear and the chromogenic substances perform a specific chromogenic reaction, so that the concentration of the component in the tear is detected by utilizing the shade of the reaction color.
2. The contact lens of claim 1, wherein the inner layer and the outer layer are the same shape and have an arc that matches the shape of the eye.
3. The contact lens of claim 1 wherein the flow channel comprises a plurality of tear inlets and a tear outlet in parallel.
4. A contact lens according to any one of claims 1 to 3, wherein said flow channel comprises a main body flow channel having a square cross section, and wherein there is a small flow channel having a square cross section in said flow channel, said small flow channel having a smaller cross sectional dimension than said main body flow channel for preventing a reverse flow of tear fluid from said tear fluid outlet to said tear fluid inlet.
5. The contact lens of claim 4 wherein said minor flow channel is disposed rearward of the junction of said cavity and said flow channel proximate said tear outlet.
6. The contact lens of claim 4, wherein the side length of the cross section of the main body flow channel is 0.3mm, and the side length of the cross section of the small flow channel is 0.2 mm.
7. A contact lens according to any of claims 1 to 3, wherein there is a gradient in the size of the cross section.
8. The contact lens of claim 7, wherein the microchannel comprises a first step at a first angle to the flow channel and a second step at a second angle to the flow channel, the first angle being greater than the second angle, and the gradient of the second step changing more steeply than the gradient of the first step.
9. The contact lens of any of claims 1 to 3, wherein the inner layer comprises a plurality of microstructures, the microstructures being circumferentially equidistantly distributed on the inner layer, each microstructure forming the flow channel and the cavity, and the outer layer comprises a plurality of cavity films, the cavity films corresponding to the cavities on each microstructure one to one.
10. The contact lens of claim 9, wherein 3 of said microstructures are equally spaced on said inner layer.
CN201811038240.5A 2018-09-06 2018-09-06 Tear detection contact lens based on capillary force driving Active CN109044411B (en)

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111631754B (en) * 2020-05-26 2021-07-09 清华大学 Automatic sampling system of pharynx swab

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060050229A1 (en) * 2003-04-07 2006-03-09 Arkadiy Farberov Universal gonioscope-contact lens system for intraocular laser surgery
CN101135682A (en) * 2006-08-29 2008-03-05 国际商业机器公司 Micro-fluidic test apparatus and method
US20100113901A1 (en) * 2008-10-24 2010-05-06 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears
CN103109186A (en) * 2010-06-30 2013-05-15 安派科生物医学科技有限公司 Apparatus for disease detection
US20140192315A1 (en) * 2012-09-07 2014-07-10 Google Inc. In-situ tear sample collection and testing using a contact lens
US20140240671A1 (en) * 2009-04-01 2014-08-28 Tearscience, Inc. Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms
CN104545793A (en) * 2015-01-28 2015-04-29 厦门大学 Noncontact-type tear film breakup time measuring device and method
CN104718448A (en) * 2012-10-12 2015-06-17 谷歌公司 Microelectrodes in an ophthalmic electrochemical sensor
US20150312560A1 (en) * 2014-01-08 2015-10-29 Michael Frank Deering Variable Resolution Eye Mounted Displays
CN105353527A (en) * 2015-11-10 2016-02-24 丹阳佰易视光学眼镜有限公司 Contact lens
CN106415268A (en) * 2014-06-20 2017-02-15 索尼公司 Detection device and method, and program
CN107402456A (en) * 2016-04-14 2017-11-28 庄臣及庄臣视力保护公司 Method and apparatus for increasing Ophthalmoligic instrument oxygen concentration
CN108152087A (en) * 2018-01-03 2018-06-12 沈阳何氏眼科医院有限公司 A kind of tear remote collection for being used to diagnose dry eyes and analytical equipment and analysis method
CN108463323A (en) * 2015-11-11 2018-08-28 万福克斯视觉公司 Band chamber adjustable lens

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85860A (en) * 1988-03-24 1992-06-21 Amir Cohen Contact lens
CN100596332C (en) * 2008-08-20 2010-03-31 东南大学 Medicine-carrying contact lens and preparation method thereof
US20140088381A1 (en) * 2012-09-26 2014-03-27 Google Inc. Facilitation of tear sample collection and testing using a contact lens
KR101571467B1 (en) * 2014-11-21 2015-11-24 한국과학기술연구원 Apparatus for collecting tear
CN105974611B (en) * 2016-07-27 2019-01-29 东南大学 The multi-functional detection contact lenses of one kind and its preparation and inspection method
KR101877312B1 (en) * 2016-11-22 2018-07-12 한국과학기술연구원 Contact lens for collecting tear or delivering drug, and Method for manufacturing the contact lens
CN107312711B (en) * 2017-06-26 2020-02-07 清华大学深圳研究生院 Self-circulation tissue/organ chip device and manufacturing method thereof

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060050229A1 (en) * 2003-04-07 2006-03-09 Arkadiy Farberov Universal gonioscope-contact lens system for intraocular laser surgery
CN101135682A (en) * 2006-08-29 2008-03-05 国际商业机器公司 Micro-fluidic test apparatus and method
US20100113901A1 (en) * 2008-10-24 2010-05-06 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears
US20140240671A1 (en) * 2009-04-01 2014-08-28 Tearscience, Inc. Methods and apparatuses for determining contact lens intolerance in contact lens wearer patients based on dry eye tear film characteristic analysis and dry eye symptoms
CN103109186A (en) * 2010-06-30 2013-05-15 安派科生物医学科技有限公司 Apparatus for disease detection
US20140192315A1 (en) * 2012-09-07 2014-07-10 Google Inc. In-situ tear sample collection and testing using a contact lens
CN104718448A (en) * 2012-10-12 2015-06-17 谷歌公司 Microelectrodes in an ophthalmic electrochemical sensor
US20150312560A1 (en) * 2014-01-08 2015-10-29 Michael Frank Deering Variable Resolution Eye Mounted Displays
CN106415268A (en) * 2014-06-20 2017-02-15 索尼公司 Detection device and method, and program
CN104545793A (en) * 2015-01-28 2015-04-29 厦门大学 Noncontact-type tear film breakup time measuring device and method
CN105353527A (en) * 2015-11-10 2016-02-24 丹阳佰易视光学眼镜有限公司 Contact lens
CN108463323A (en) * 2015-11-11 2018-08-28 万福克斯视觉公司 Band chamber adjustable lens
CN107402456A (en) * 2016-04-14 2017-11-28 庄臣及庄臣视力保护公司 Method and apparatus for increasing Ophthalmoligic instrument oxygen concentration
CN108152087A (en) * 2018-01-03 2018-06-12 沈阳何氏眼科医院有限公司 A kind of tear remote collection for being used to diagnose dry eyes and analytical equipment and analysis method

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