CN108939158A - Small intestine acellular matrix film combination metal mesh breast wall repairing material - Google Patents
Small intestine acellular matrix film combination metal mesh breast wall repairing material Download PDFInfo
- Publication number
- CN108939158A CN108939158A CN201810839039.0A CN201810839039A CN108939158A CN 108939158 A CN108939158 A CN 108939158A CN 201810839039 A CN201810839039 A CN 201810839039A CN 108939158 A CN108939158 A CN 108939158A
- Authority
- CN
- China
- Prior art keywords
- metal mesh
- small intestine
- matrix film
- acellular matrix
- chest
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material, belongs to biomaterial for medical purpose field.The material includes: small intestine acellular matrix film to be produced out after the small intestine that will be intercepted in animals is processed, then small intestine acellular matrix film is produced out wall of the chest patching material in conjunction with metal mesh.Material preparation method of the invention is simple, and obtained wall of the chest patching material is repaired the wall of the chest as chest wall defect patient and used, and has vast potential for future development.
Description
Technical field
The invention belongs to biomaterial for medical purpose fields, and in particular to a kind of small intestine acellular matrix film combination metal mesh wall of the chest
Patching material.
Background technique
There is chest wall defect in many severe trauma patients in clinic, be easy to cause pendular movement of mediastinum when defect area is larger,
Patient vitals are on the hazard, and routine operation is sectional repair, or take the tissue at other positions of body or a part of organ
It is repaired, causes certain damage again while curing the disease.With the correlation of small intestine acellular matrix film (ECM) biological sticking patch
Progress of research, my Research Team have developed a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material, the material
Clinical application range is extensive, to be applied to the reparation of pleura, the wall of the chest, skull etc..The patching material has vast potential for future development,
The development of bioartificial materials will be pushed.
Summary of the invention
The purpose of the invention is to provide a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material, the system
Standby material structure is simple, and obtained wall of the chest patching material plays huge impetus to producing for artificial organs.
Present invention firstly provides a kind of small intestine acellular matrix film combination metal mesh breast wall repairing materials:
Step 1: acellular matrix film is produced with the small intestine intercepted in animals；
Step 2: different size of metal mesh is produced using titanium nickel alloy material, metal mesh is in slightly to protrude to plane side
Arachnoid Ti-Ni alloy metal mesh；
Step 3: the small intestine acellular matrix film that step 1 obtains is fixed on the metal mesh that step 2 obtains, is obtained
Wall of the chest patching material；
Step 4: the wall of the chest patching material that step 3 is obtained is through linear accelerating with 8000 ladd radiological dose radiation sterilizations
After be sealed.
Preferably, the animal of the step one is pig, ox, sheep, mouse, horse.
Preferably, the metal of the step one is Ti-Ni alloy.
Preferably, the acellular matrix film of the step one is that the small intestine intercepted with living animal passes through processing
Obtained small intestine acellular matrix film.
Preferably, the advantages of the step two metal mesh specifically: produce different size using titanium nickel alloy material
Metal mesh, metal mesh have certain toughness and elasticity, be implanted into the wall of the chest after cannot with thoracic cavity internal and external pressure difference change and generate
Activity.
Preferably, the combination method of the acellular matrix film and metal mesh of the step three are as follows: obtain step 1
Small intestine acellular matrix film be fixed on the metal mesh that step 2 obtains, obtain wall of the chest patching material.
Preferably, the sterilizing of the step four is that the wall of the chest patching material that will be sealed is drawn through linear accelerating with 8000
It is saved after moral radiological dose radiation sterilization.
The present invention provides the wall of the chest sticking patch material of small intestine acellular matrix film that above-mentioned preparation method obtains in conjunction with metal mesh
Material.
Beneficial effects of the present invention
Present invention firstly provides a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material, wherein metal material
For titanium nickel alloy material, the material is caused, and adverse reaction is few, has been widely used for the reparation of human body or consolidating as fracture
Device is determined applied to human body.The web-like structure slightly protruded is put centered on the metal mesh, the structural stability is more preferable, not variable
Shape can resist bigger tension with less material, reduce influence of the metallics to human body.Acellular matrix film and metal mesh
Combination be that metal mesh is fixed on specific holder device, by small intestine acellular matrix film along the diameter of circular metal net
The two sides of metal mesh are tiled and be wound in, can be closely linked with metal mesh.
Detailed description of the invention
Fig. 1 is the photo figure for the natural tubulose chitterlings acellular matrix film of single layer that the present invention is prepared.
Fig. 2 is before the single layer natural tubulose chitterlings acellular matrix film of the invention being prepared is dry in conjunction with metal mesh
Photo figure.
Fig. 3 is after the single layer natural tubulose chitterlings acellular matrix film of the invention being prepared is dry in conjunction with metal mesh
Photo figure.
Specific embodiment
Present invention firstly provides a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material, which includes two
Part, small intestine acellular matrix film and its preparation method of metal mesh are as follows:
Step 1: taking the white pig of real estate 1, weight in 50-100Kg, using my seminar's invention " natural tubulose small intestine is de-
Cellular matrix film and its preparation method " preparation method produce the natural tubulose acellular matrix film of small intestine, then its stringer is splitted
Produce sheet acellular matrix film.
Step 2: different size of metal mesh is produced using titanium nickel alloy material, metal mesh has certain toughness and bullet
Property, it cannot change and generation activity with thoracic cavity internal and external pressure difference after being implanted into the wall of the chest.The Ti-Ni alloy wire that this experiment uses is straight
Diameter is respectively as follows: two kinds of specifications of 1.0mm and 0.8mm.First take the Ti-Ni alloy wire right-angled intersection of 2 diameters 1.0mm, long 10cm
And weld together crosspoint, one group is separately welded with method, the wire that 2 groups of crosses are welded will be round by the center of circle of pad
2 pads are welded together after average 8 equal parts, pound downhand welding contact, its thickness is made to be no more than 2mm, and by its central point to flat
It slightly protrudes the side in face.The Ti-Ni alloy wire for taking diameter 0.8mm long 50cm, is made into spiral shape by the center of circle of one end,
And keep all wires in one plane, adjacent two wires spacing 5.0mm.The wire of both the above specification is folded
Add, and weld the wire of overlapping, obtains center slightly to the arachnoid metal mesh of plane side protrusion.
Step 3: the small intestine acellular matrix film that step 1 obtains is fixed on the metal mesh that step 2 obtains, is obtained
Wall of the chest sticking patch.The metal mesh that step 2 is obtained first is fixed in particular stent, and the small intestine that step 1 is obtained takes off cell base
Plasma membrane is laid on the metal mesh that step 2 obtains, and winds repeatedly, so that acellular matrix film is overlapped layer 2-4, keeps certain
Tension, in order to avoid generate fold and by edge locked in the edge of metal mesh.
Step 4: the wall of the chest patching material that step 3 is obtained is through linear accelerating with 8000 ladd radiological dose radiation sterilizations
After be sealed.
According to the present invention, the small intestine that will be intercepted in animals is handled, and obtains small intestine acellular matrix film,
The animal is not particularly limited, preferably pig, ox, sheep, mouse or horse.
Described to handle according to the present invention, the wire for obtaining Ti-Ni alloy is handled to obtain metal mesh, described
Metal mesh be made of wire, preferably Ti-Ni alloy material material.
According to the present invention, producing for small intestine acellular matrix film is seminar invent that " natural tubulose small intestine takes off using me
Cellular matrix film and preparation method thereof " in preparation method produce out natural tubulose acellular matrix film after tubulose is taken off into cell again
Matrix membrane stringer is splitted, and sheet small intestine acellular matrix film is obtained.
According to the present invention, metal mesh is to use Ti-Ni alloy wire for main material.
According to the present invention, small intestine acellular matrix film combination metal mesh breast wall repairing material obtained above is done
Dry, sealing, sterilizing save, spare.The intestines acellular matrix film combination metal mesh that the sterilizing will preferably be sealed produces chest
Wall patching material is through linear accelerating with 8000 ladd radiological dose radiation sterilizations.
It below for illustrating the present invention, but is not used in and limits the scope of the invention, unless otherwise specified, used in the present invention
The conventional means that are well known to those skilled in the art of technological means, raw materials used is commercial goods.
1. sheet ECM's produces
Take the white pig of real estate 1, weight in 50-100Kg, using my seminar's invention " natural tubulose small intestine takes off cell base
Plasma membrane and its preparation method " preparation method produce the natural tubulose acellular matrix film of small intestine, then its stringer is splitted and produces piece
Shape acellular matrix film.
2. Ti-Ni alloy metal mesh is produced
Ti-Ni alloy wire is taken, produces to obtain center slightly to the arachnoid metal mesh of plane side protrusion.
Fig. 1 is the photo figure of single layer chitterlings acellular matrix film of the present invention；Fig. 2 is de- for single layer sheet chitterlings of the present invention
Photo figure before cellular matrix film is dry in conjunction with metal mesh；
Fig. 3 is the photo figure after single layer sheet chitterlings acellular matrix film of the present invention is dry in conjunction with metal mesh；Fig. 2 is extremely
Fig. 3 explanation, acellular matrix film are tightly combined with metal mesh, successfully produce the small intestine acellular matrix film combination metal mesh wall of the chest and repair
Mend material.
Claims (6)
1. small intestine acellular matrix film combination metal mesh breast wall repairing material, which is characterized in that the material, which makes, includes:
Step 1: acellular matrix film is produced with the small intestine intercepted in animals；
Step 2: producing different size of metal mesh using titanium nickel alloy material, and metal mesh has certain toughness and elasticity, plants
It cannot change and generation activity with thoracic cavity internal and external pressure difference after entering the wall of the chest；
Step 3: the small intestine acellular matrix film that step 1 obtains is fixed on the metal mesh that step 2 obtains, the wall of the chest is obtained
Patching material；
Step 4: the wall of the chest patching material that step 3 is obtained is close after linear accelerating is with 8000 ladd radiological dose radiation sterilizations
Envelope saves.
2. a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material according to claim 1, feature exist
In the animal of the step one is pig, ox, sheep, mouse, horse, and metal material is titanium nickel alloy material.
3. a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material according to claim 1, feature exist
In the acellular matrix film in the step one is the acellular matrix film that the small intestine of living animal is produced.
4. a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material according to claim 1, feature exist
In the metal material of the step two is titanium nickel alloy material, and the material is caused, and adverse reaction is few, is had been widely used for
The reparation of human body or fixation device as fracture are applied to human body, put the spider slightly protruded to plane side centered on the metal mesh
Reticular structure, the structural stability is more preferable, is unlikely to deform, and bigger tension can be resisted with less material, reduces metallics
Influence to human body.
5. a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material according to claim 1, feature exist
In the combination of step three the small intestine acellular matrix film and metal mesh specifically: metal mesh is fixed on specific bracket
On device, small intestine acellular matrix film is tiled along the diameter of circular metal net and is wound in the two sides of metal mesh, it can be with
Metal mesh is closely linked.
6. a kind of small intestine acellular matrix film combination metal mesh breast wall repairing material according to claim 1, feature exist
In the sterilizing of the step four is that the wall of the chest patching material that will be sealed is irradiated through linear accelerating with 8000 ladd radiological doses
Sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810839039.0A CN108939158A (en) | 2018-07-27 | 2018-07-27 | Small intestine acellular matrix film combination metal mesh breast wall repairing material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810839039.0A CN108939158A (en) | 2018-07-27 | 2018-07-27 | Small intestine acellular matrix film combination metal mesh breast wall repairing material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108939158A true CN108939158A (en) | 2018-12-07 |
Family
ID=64464071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810839039.0A Pending CN108939158A (en) | 2018-07-27 | 2018-07-27 | Small intestine acellular matrix film combination metal mesh breast wall repairing material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108939158A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1658914A (en) * | 2002-04-09 | 2005-08-24 | 艾斯特勒科技公司 | Medical prosthetic devices having improved biocompatibility |
| CN201316330Y (en) * | 2008-10-15 | 2009-09-30 | 周星 | Combined tissue-engineered coelomic duct substitute |
| WO2010003062A2 (en) * | 2008-07-03 | 2010-01-07 | The Regents Of The University Of California | Biomaterials and implants for enhanced cartilage formation, and methods for making and using them |
| CN101626791A (en) * | 2007-03-07 | 2010-01-13 | 科洛普拉斯特公司 | Mesh comprising ECM |
| CN201379820Y (en) * | 2009-04-27 | 2010-01-13 | 宋永春 | Biological activity coating implantation high-intensity titanium alloy wire for breastbone closure |
| EP2578245A2 (en) * | 2011-09-01 | 2013-04-10 | Covidien LP | Hydrogel coated magnesium medical implants |
| CN105311678A (en) * | 2015-11-24 | 2016-02-10 | 无锡中科光远生物材料有限公司 | Complex hernia patch and preparing method and application thereof |
-
2018
- 2018-07-27 CN CN201810839039.0A patent/CN108939158A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1658914A (en) * | 2002-04-09 | 2005-08-24 | 艾斯特勒科技公司 | Medical prosthetic devices having improved biocompatibility |
| CN101626791A (en) * | 2007-03-07 | 2010-01-13 | 科洛普拉斯特公司 | Mesh comprising ECM |
| WO2010003062A2 (en) * | 2008-07-03 | 2010-01-07 | The Regents Of The University Of California | Biomaterials and implants for enhanced cartilage formation, and methods for making and using them |
| CN201316330Y (en) * | 2008-10-15 | 2009-09-30 | 周星 | Combined tissue-engineered coelomic duct substitute |
| CN201379820Y (en) * | 2009-04-27 | 2010-01-13 | 宋永春 | Biological activity coating implantation high-intensity titanium alloy wire for breastbone closure |
| EP2578245A2 (en) * | 2011-09-01 | 2013-04-10 | Covidien LP | Hydrogel coated magnesium medical implants |
| CN105311678A (en) * | 2015-11-24 | 2016-02-10 | 无锡中科光远生物材料有限公司 | Complex hernia patch and preparing method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101627933B (en) | Covered stent | |
| EP2608815B1 (en) | Biomaterials with enhanced properties and devices made therefrom | |
| CN107007886B (en) | A kind of biological tissue's host material, preparation method and its usage | |
| JP5714491B2 (en) | Method for producing cell-free matrix adhesive | |
| WO2018121630A1 (en) | Composite tissue repair sheet and preparation method and application thereof | |
| US10561484B2 (en) | Hernia mesh and its preparation method | |
| CN106267347B (en) | Basin bottom biological sticking patch and preparation method thereof | |
| WO2015021807A1 (en) | Breast prosthesis support device based on tissue matrix material, and preparation method therefor | |
| CN102068714A (en) | Collagen sponge and preparation method thereof | |
| CN102335052A (en) | Anti-restenosis digestive tract stent | |
| CN110101912A (en) | A kind of drying artificial biological heart valve and preparation method thereof of the endothelialization polypeptide containing promotion | |
| JP2017512563A (en) | Decellularized pleural matrix | |
| CN105311679A (en) | Complex hernia patch and preparing method and application thereof | |
| CN110101911A (en) | A kind of drying artificial biological heart valve and preparation method thereof of the endothelialization growth factor containing promotion | |
| US20220071660A1 (en) | Organ Enclosures For Inhibiting Tumor Invasion And Detecting Organ Pathology | |
| CN109640882A (en) | A kind of complete biological absorbable blood vessel polymer support of implanted | |
| CN108939158A (en) | Small intestine acellular matrix film combination metal mesh breast wall repairing material | |
| CN107286359B (en) | Hydrogel with heterogeneous multilayer structure and preparation method thereof | |
| CN201316331Y (en) | Biologically induced composite artificial esophagus | |
| CN108939159A (en) | Small intestine acellular matrix film combination metal mesh wall of the chest sticking patch preparation method | |
| WO2023196236A2 (en) | Adaptive patches for dynamic organs | |
| CN203591289U (en) | In-vivo absorbable metal closing nail of three-dimensional structure | |
| CN207708052U (en) | Chest rib replacing part before a kind of 3D printing titanium alloy | |
| CN112587723B (en) | In-situ rapid-forming magnetic hydrogel for repairing urinary system and preparation method thereof | |
| CN109276745A (en) | A kind of cellulose combine dressing of high wet strength and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181207 |
|
| WD01 | Invention patent application deemed withdrawn after publication |