CN108937896A - A kind of central aortic blood pressure measuring method and equipment - Google Patents
A kind of central aortic blood pressure measuring method and equipment Download PDFInfo
- Publication number
- CN108937896A CN108937896A CN201710369140.XA CN201710369140A CN108937896A CN 108937896 A CN108937896 A CN 108937896A CN 201710369140 A CN201710369140 A CN 201710369140A CN 108937896 A CN108937896 A CN 108937896A
- Authority
- CN
- China
- Prior art keywords
- blood pressure
- peripheral arterial
- central aortic
- pressure waveform
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
- A61B5/0225—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Psychiatry (AREA)
- Signal Processing (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The embodiment of the invention discloses a kind of central aortic blood pressure measuring method and equipment, this method comprises: the blood pressure waveform of measurement peripheral arterial changed over time；Blood flow is obtained from central aortic to the propagation time of the blood pressure measurement location of the peripheral arterial；The blood pressure waveform of the central aortic is calculated using the blood pressure waveform and the propagation time of the peripheral arterial.Measuring center arterial blood pressure waveform calculation amount is less through the above way, and only needs to measure the blood pressure of single peripheral arterial, and measurement difficulty is low, easy to use, can reduce measurement cost, and can embody individual difference.
Description
Technical field
The present embodiments relate to biomedical engineering field, more particularly to a kind of central aortic blood pressure measuring method and
Equipment.
Background technique
Central aortic blood pressure (CAP) is independently of the disease forecasting factor of brachial arterial pressure, it is for caused by hypertension
Arterial function degenerate case plays direct predicting function, research in recent years discovery, and central aortic blood pressure evaluates hypertension therapeutic effect
Fruit, disease prognosis situation, artery structure function etc. all measure more acurrate, clinical value than traditional arm brachial arterial pressure
It is higher.
The present inventor has found in studying for a long period of time, double peripheries central aortic blood pressure measurement used by the prior art
Method needs to measure double peripheral arterial blood pressures, and calculation amount is larger, and inconvenient for use and equipment is expensive.
Summary of the invention
The embodiment of the present invention is mainly solving the technical problems that provide a kind of central aortic blood pressure measuring method and equipment, energy
Enough solve the problems, such as that existing double periphery central aortic blood pressure measuring methods are computationally intensive, inconvenient for use.
In order to solve the above technical problems, a technical solution used in the embodiment of the present invention is: providing a kind of central aortic
Blood pressure measuring method, comprising: measure the blood pressure waveform of peripheral arterial changed over time；Blood flow is obtained from central aortic to periphery
The propagation time of the blood pressure measurement location of artery；The blood of central aortic is calculated using the blood pressure waveform of peripheral arterial and propagation time
Corrugating.
In order to solve the above technical problems, another technical solution used in the embodiment of the present invention is: providing aroused in interest in one kind
Arteries and veins blood pressure measurement device, comprising: peripheral arterial measuring instrument, the blood pressure waveform changed over time for measuring peripheral arterial；Processing
Device connects peripheral arterial measuring instrument, when for obtaining the propagation of blood pressure measurement location of the blood flow from central aortic to peripheral arterial
Between, the blood pressure waveform of central aortic is calculated using the blood pressure waveform of peripheral arterial and propagation time.
The beneficial effect of the embodiment of the present invention is: in the method for the embodiment of the present invention, by measurement peripheral arterial with
The blood pressure waveform of time change obtains the propagation time of blood pressure measurement location of the blood flow from central aortic to peripheral arterial, finally
The blood pressure waveform of central aortic can be calculated using the blood pressure waveform of peripheral arterial and propagation time, according to single outer in this method
The blood pressure waveform of central aortic can be calculated in all arterial blood pressure waveforms and blood flow propagation time, and calculation amount is less, and only needs
The blood pressure of single peripheral arterial is measured, measurement difficulty is low, and it is easy to use, and can reduce measurement cost.
Detailed description of the invention
Fig. 1 is the flow chart of central aortic blood pressure measuring method first embodiment of the present invention；
Fig. 2 is the schematic diagram of single arteries model used by method shown in FIG. 1；
Fig. 3 is that finger blood vessel closes experiment schematic diagram；
Fig. 4 is the flow chart of central aortic blood pressure measuring method second embodiment of the present invention；
Fig. 5 is the flow chart of central aortic blood pressure measuring method 3rd embodiment of the present invention；
Fig. 6 is the structural schematic diagram of central aortic blood pressure measurement device first embodiment of the present invention；
Fig. 7 is the structural schematic diagram of central aortic blood pressure measurement device second embodiment of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that the described embodiments are merely a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Referring to Fig. 1, Fig. 1 is the flow chart of central aortic blood pressure measuring method first embodiment of the present invention.Such as Fig. 1 institute
Show, central aortic blood pressure measuring method of the present invention includes:
Step S11: the blood pressure waveform of peripheral arterial changed over time is measured；
Specifically, it is based on hemodynamic basic principle, initially sets up single arteries model 20, as shown in Fig. 2,
Assuming that the characteristic that central aortic 2012 has pure elasticity lossless to peripheral arterial blood vessel, and the independent signal of time domain can be write as
Fourier series, the smooth blood flow and mean blood pressure of 201 each position of blood vessel are equal, and characteristic impedance is with ZRIt indicates.At blood vessel end
End, what is be attached thereto is a Windkessel model 202, and to describe distal vessels subsystem characteristics, which can be by
One equivalent features impedance Z (ω) indicates.In blood vessel end, due to impedance mismatch, there are reflexes for arterial system, from the heart
The dirty blood flow for flowing to peripheral arterial is defined as advancing wave, and the superposition of peripheral blood vessel reflective portion everywhere, is flowed to by peripheral arterial
The blood flow of heart is defined as back wave.Wherein, advancing wave and back wave are pressure wave, and actually measured blood pressure waveform is by preceding
It is formed by stacking into wave and back wave.
In addition, human body, in quiescent condition, typical finger blood flow is only 0.05ml/min, so slow blood flow velocity table
Show that unit time blood flow is seldom, the terminal resistance that imply finger artery is very big, then finger arteries can approximation regard as
To be in close state, therefore, the advancing wave of finger arterial pressure is fully reflective to become back wave, the blood pressure of finger artery measurement
Waveform is two times of advancing wave.
In order to verify finger arteries can approximation see as and be in close state, as shown in figure 3, being arranged at finger end
Two cufves, wherein cuff 1 connects finger arterial blood pressure measuring device, for measuring the blood pressure waveform (Digital of finger artery
Arterial Pressure, DAP), cuff 2 connects air charging system, for applying pressure to finger arteries in inflation,
So that finger arteries is in close state.Wherein, the blood pressure waveform that the finger artery is measured using volume-compensation method, when
So, in other embodiments, the blood pressure waveform of finger artery can also be measured using other methods such as pulse wave conduction speed methods,
It is not specifically limited herein.
By measure 30 volunteer's finger arteries blood pressure waveform, including finger arteries be in non-closed state with
After the blood pressure waveform of closed state, statistics is obtained such as the data in the following table 1:
1 experimental result of table
Wherein, n indicates to test the sample size chosen in the blood pressure waveform measured, and p-value assumes that probability, expression pair
The degree of support of null hypothesis generallys use significance 0.05 compared with p-value, when p-value is greater than 0.05, supports
Otherwise original hypothesis refuses original hypothesis.Therefore, there is above-mentioned experimental result it is found that p-value is all larger than 0.05, i.e. finger is dynamic
When arteries and veins blood vessel is in non-closed state and closed state, finger arterial blood pressure waveform is without significant change, that is to say, that finger artery
Blood vessel can approximation see as and be in close state.
As a result, in an application examples, based on single arteries model 20 as shown in Figure 2, set at finger end 2011
Measuring device, such as blood pressure measuring cuff are set, measures the blood pressure waveform of the finger artery changed over time, wherein finger artery
Blood pressure waveform measurement method can use volume-compensation method.Certainly, in other application example, the blood pressure waveform of finger artery
Other measurement methods can be used, if the blood vessel of other peripheral arterials can also approximation regard as and be in close state, can also survey
The blood pressure waveform for measuring other peripheral arterials, is not specifically limited herein.
Wherein, step S11 further comprises:
Step S111: the ECG signal that synchro measure changes over time；
Specifically, in above application examples, cardiographic detector is set in cardia 2012, it can be with by cardiographic detector
The ECG signal that synchro measure changes over time.
Step S12: the propagation time of blood pressure measurement location of the blood flow from central aortic to peripheral arterial is obtained；
Wherein, step S12 further comprises:
Step S121: using the phase difference calculating blood flow between ECG signal and the blood pressure waveform of peripheral arterial from center
Propagation time of the artery to peripheral arterial blood pressure measurement location.
Specifically, blood is penetrated to cardiac cycle, blood flow generates periodic blood pressure pulse wave, these waves along arterial flow
Shape is with the delay for the different meeting having times for being centrifuged dirty distance, i.e. blood flow propagation time (PTT).In an application examples, it is based on
The principle of photoelectricity volumetric measurement pulse wave propagation time is arranged a photoelectric sensor in finger artery site 2011, records photoelectricity
Volume pulsation wave (PPG) is arranged a cardiographic detector in cardia 2012, records ECG signal (ECG), by one
In period, the phase difference between the R wave crest location of ECG signal and the PPG signal of synchro measure is calculated, it can obtain blood flow
From the propagation time of central aortic Digital arteries blood pressure measurement location in one's hands.Certainly, in other application example, which can also
To be calculated using other methods, it is not specifically limited herein.
Step S13: the blood pressure waveform of central aortic is calculated using the blood pressure waveform of finger artery and propagation time.
Wherein, step S13 further comprises:
Step S131: the advancing wave of the blood pressure measurement location of peripheral arterial and anti-is decomposed using the blood pressure waveform of peripheral arterial
Ejected wave；
Wherein, step S131 further comprises:
Step S1311: advancing wave and back wave are decomposited by following formula:
Wherein, pDf(t) value for the advancing wave of peripheral arterial blood pressure measurement location in t moment, pDbIt (t) is peripheral arterial
Value of the back wave of blood pressure measurement location in t moment, PDIt (t) is blood pressure of the peripheral arterial blood pressure measurement location in t moment.
Specifically, single arteries model shown in Fig. 2, blood of the blood flow from the Digital arteries in one's hands of central aortic 2012 are based on
In blood vessel 201 between pressure measurement position 2011 when flowing to distal vessels 202, in 201 end of blood vessel, not due to impedance
Match, there are reflexes for blood flow, to advancing wave and back wave occur, simultaneously as finger arteries can approximation regard place as
In closed state, therefore, in 201 end of blood vessel, fully reflective advancing wave is back wave, i.e., as shown in Fig. 2, on frequency domain,
The reflection coefficient of 201 end of blood vessel
Wherein, Γ (ω) is value of the reflection coefficient of peripheral arterial blood pressure measurement location in ω frequency point, Pf(ω) is periphery
Value of the advancing wave of arterial pressure measurement position in ω frequency point, Pb(ω) is the back wave of peripheral arterial blood pressure measurement location in ω
The value of frequency point.Likewise, in time domain, the reflection coefficient
Therefore, by above-mentioned formula, the blood pressure waveform and step S1311 that can use the finger artery measured are calculated
The advancing wave and back wave of the blood pressure measurement location of finger artery out.
Step S132: center is calculated using the advancing wave and back wave of finger arterial pressure measurement position and propagation time
The blood pressure waveform of artery.
Wherein, step S132 further comprises:
Step S1321: the blood pressure waveform of central aortic is calculated by following formula:
PC(t)=pDf(t+Δt)+pDb(t-Δt)；
Wherein, PCIt (t) is blood pressure of the center artery in t moment, pDf(t+ Δ t) and pDb(t- Δ t) is the blood of peripheral arterial
For the advancing wave and back wave of pressure detection position respectively in the value of t+ Δ t and t- time Δt, Δ t is blood flow from central aortic to outer
The propagation time of the blood pressure measurement location of all arteries.
Specifically, it is based on single arteries model shown in Fig. 2, the blood pressure measurement location of finger artery in blood vessel 201
2011 advancing waves that measure are to be propagated by the advancing wave of central aortic 2012 by the Δ t time, and central aortic 2012
Back wave be then that the back wave that is measured by the blood pressure measurement location 2011 of finger artery is propagated by the Δ t time, by
This can obtain the advancing wave of central aortic 2012 by the advancing wave and back wave of the blood pressure measurement location 2011 of finger artery
And back wave, and since actually measured blood pressure waveform is the benefit as made of the pressure superposition of advancing wave and back wave
With above-mentioned formula by the advancing wave of the blood pressure measurement location 2011 of finger artery and the transformed obtained central aortic of back wave
2012 advancing wave is added with back wave, and the blood pressure waveform of central aortic can be obtained.
Fig. 2 is further regarded to, on frequency domain, in the single arteries model, the blood pressure waveform P of finger arteryD(ω)
With the blood pressure waveform P of central aorticCRelationship between (ω) is
Wherein, transmission function of the H (ω) between center artery 2012 and finger arterial pressure measurement position 2011 is in ω
The value of frequency point, PC(ω) is value of the center arterial pressure in ω frequency point, PD(ω) is that the blood pressure of finger arterial pressure measurement position exists
The value of ω frequency point.
In addition, as shown in Fig. 2, the blood pressure measurement location of the advancing wave and back wave of central aortic 2012 and finger artery
The advance of the blood pressure waveform and central aortic 2012 of relationship and central aortic 2012 between 2011 advancing wave and back wave
Relationship between wave and back wave is respectively
PCf(ω)=Pf(ω)ejωΔt；
PCb(ω)=Pb(ω)e-jωΔt；
PC(ω)=PCf(ω)+PCb(ω)；
Wherein, PC(ω) is value of the center arterial pressure in ω frequency point, PCf(ω) is that the advancing wave of center arterial pressure exists
The value of ω frequency point, PCb(ω) is value of the transmitted wave of center arterial pressure in ω frequency point, Pf(ω) is the measurement of finger arterial pressure
Value of the advancing wave of position in ω frequency point, Pb(ω) is value of the back wave of finger arterial pressure measurement position in ω frequency point, Δ t
It is blood flow from the propagation time of the blood pressure measurement locations of central aortic Digital arteries in one's hands.
By the formula of above-mentioned formula and reflection coefficient it is found that central aortic 2012 and finger arterial pressure measurement position
Transmission function between 2011 can be obtained by following formula:
Wherein, transmission function of the H (ω) between center artery 2012 and finger arterial pressure measurement position 2011 is in ω
The value of frequency point, Γ (ω) are value of the reflection coefficient in ω frequency point of finger arterial pressure measurement position.
By above-mentioned steps S1311 it is found that the value of the reflection coefficient Γ (ω) of finger arterial pressure measurement position is 1, therefore,
Above-mentioned formula can be reduced to
Central aortic blood pressure waveform can be obtained by following formula as a result:
PC(ω)=PD(ω)cos(ωΔt)；
Wherein, PC(ω) is value of the center arterial pressure in ω frequency point, PD(ω) is the blood of finger arterial pressure measurement position
It is pressed in the value of ω frequency point.
As a result, in the time domain, central aortic blood pressure waveform can then be obtained by following formula:
Wherein, PCIt (t) is blood pressure of the center artery in t moment, PD(t+ Δ t) and PD(t- Δ t) is the survey of finger arterial pressure
The blood pressure of position is measured respectively in the value of t+ Δ t and t- time Δt, Δ t is that blood pressure of the blood flow from central aortic to peripheral arterial is surveyed
Measure the propagation time of position.
In above-described embodiment, the blood pressure waveform changed over time by measuring finger artery obtains blood flow from central aortic
It is the propagation time of the blood pressure measurement location of Digital arteries in one's hands, final to be counted using the blood pressure waveform of finger artery and blood flow propagation time
The blood pressure waveform of central aortic is calculated, only center need to can be calculated according to single peripheral arterial blood pressure waveform and blood flow propagation time
The blood pressure waveform of artery, calculation amount is less, and only needs to measure the blood pressure of single peripheral arterial, and measurement difficulty is low, easy to use, energy
Measurement cost is enough reduced, and blood pressure waveform due to the finger artery of different human body real-time measurement and blood flow propagation time deposit
Individual difference can be embodied in the central aortic blood pressure waveform of difference, this method measurement.
Certainly, in other embodiments, the blood pressure waveform that other peripheral arterials change over time can also be measured, herein not
It is specifically limited.
Referring to Fig. 4, Fig. 4 is the flow chart of central aortic blood pressure measuring method second embodiment of the present invention, in the present invention
Arteries and veins blood pressure measuring method second embodiment aroused in interest is in the present invention on the basis of arteries and veins blood pressure measuring method first embodiment aroused in interest,
Step S11 further comprises:
Step S112: the blood pressure waveform changed over time when measurement peripheral arterial closed state；
Step S113: the blood pressure waveform changed over time when the measurement non-closed state of peripheral arterial；
When being in close state due to peripheral arterial, the advancing wave of peripheral arterial blood pressure is fully reflective to become back wave, should
The blood pressure waveform of peripheral arterial measurement is two times of advancing wave, and while being in non-closed state using the peripheral arterial measures
Blood pressure waveform and closed state when blood pressure half, it can the back wave of the peripheral arterial blood pressure is calculated.
Specifically, in an application examples, based on single arteries model 20 as shown in Figure 2, in periphery arterial end
2011 setting measuring devices, such as two blood pressure measuring cuffs shown in Fig. 3, measure peripheral arterial closed state and non-closing shape
The blood pressure waveform changed over time when state, wherein the blood pressure waveform measurement method of peripheral arterial can adopt according to the actual situation
With any one or other measurement methods such as tensammetry, volume-compensation method, pulse wave conduction speed method, specific limit is not done herein
It is fixed.
As a result, further, step S131 includes:
Step S1312: the advancing wave and back wave of peripheral arterial blood pressure measurement location are decomposited by following formula:
pDb(t)=PD2(t)-pDf(t)；
Wherein, pDf(t) value for the advancing wave of peripheral arterial blood pressure measurement location in t moment, pDbIt (t) is peripheral arterial
Value of the back wave of blood pressure measurement location in t moment, PD1(t) be peripheral arterial closed state when blood pressure measurement location in t moment
Blood pressure；PD2(t) blood pressure of the blood pressure measurement location in t moment when closed state non-for peripheral arterial.
Specifically, when the peripheral arterial blood vessel cannot approximation regard as be in close state when, can be by peripheral arterial
The measuring device of blood pressure measurement location setting, measurement obtain the peripheral arterial and are in close state blood pressure wave with non-closed state
Shape, so that the advancing wave and back wave of the peripheral arterial blood pressure measurement location can be decomposited, according to above-mentioned formula so as to subsequent
Calculate the blood pressure waveform of central aortic.When the peripheral arterial blood vessel can approximation regard as be in close state when, can refer to step
S1311 is not repeated herein.
The present embodiment can be combined with central aortic blood pressure measuring method first embodiment of the present invention.Pass through above-mentioned side
Method can use the blood pressure waveform that peripheral arterial blood vessel is in close state with measures when non-closed state, decomposite advancing wave
And back wave, so as to subsequent calculating central aortic blood pressure waveform, this method calculates simple, and measurement is convenient, can reduce measurement at
Originally, and the blood pressure waveform due to the finger artery of different human body real-time measurement and blood flow propagation time have differences, the party
The central aortic blood pressure waveform of method measurement can embody individual difference.
Referring to Fig. 5, Fig. 5 is the flow diagram of central aortic blood pressure measuring method 3rd embodiment of the present invention.Such as Fig. 5
Shown, central aortic blood pressure measuring method 3rd embodiment of the present invention is that arteries and veins blood pressure measuring method first aroused in interest is real in the present invention
On the basis of applying example, step S12 includes:
Step S122: the propagation of blood pressure measurement location of the priori knowledge estimation blood flow from central aortic to peripheral arterial is utilized
Time.
Specifically, in an application examples, for each measurement object, the blood pressure that its peripheral arterial changes over time is measured
Waveform extracts the pressure value of diastole, according to single arteries model as shown in Figure 2 and from heart to the peripheral arterial blood
The priori knowledges such as the blood vessel average length of measurement position are pressed, can estimate to obtain blood pressure of the blood flow from central aortic to peripheral arterial
The propagation time of measurement position.According to the average data of multiple measurement objects, the propagation time finally estimated can be obtained.When
So, in other application example, the pressure value of the blood pressure waveform or systole phase that can also extract peripheral arterial whole cycle is estimated
Meter, is not specifically limited herein.
The step of the present embodiment, can be with central aortic blood pressure measurement side of the present invention with alternative steps S121, the present embodiment
The first, second embodiment of method combines.
Referring to Fig. 6, Fig. 6 is the structural schematic diagram of central aortic blood pressure measurement device first embodiment of the present invention.Such as Fig. 6
Shown, 60 first embodiment of central aortic blood pressure measurement device of the present invention includes: peripheral arterial measuring instrument 601 and processor
602。
Peripheral arterial measuring instrument 601, the blood pressure waveform changed over time for measuring peripheral arterial；
Processor 602 connects peripheral arterial measuring instrument 601, for obtaining blood of the blood flow from central aortic to peripheral arterial
The propagation time for pressing measurement position calculates the blood pressure waveform of central aortic using the blood pressure waveform of peripheral arterial and propagation time.
Specifically, in an application examples, peripheral arterial measuring instrument, such as Fig. 3 institute are set in person's finger position to be tested
The device shown measures the blood pressure waveform that finger artery changes over time using volume-compensation method, can refer to step S11, this
Place is not repeated；Then the blood pressure waveform that the finger artery of measurement changes over time is transferred to processor 602, processor 602
According to the blood pressure waveform of acquisition, the biography of blood pressure measurement location of the priori knowledge estimation blood flow from central aortic to peripheral arterial is utilized
Between sowing time, step S122 is specifically referred to, is not repeated herein；Finally counted using the blood pressure waveform of peripheral arterial and propagation time
The blood pressure waveform of central aortic is calculated, step S13 can be specifically referred to, be not repeated herein.
Certainly, in other application example, the blood pressure waveform of other peripheral arterials can be measured, blood pressure waveform can also pass through
Other method measurements, peripheral arterial measuring instrument are also possible to other devices, and blood pressure of the blood flow from central aortic to peripheral arterial is surveyed
The propagation time of amount position can also obtain by other means, be not specifically limited herein.
Certainly, in other embodiments, central aortic blood pressure measurement device depending on specific requirements can also include display, press
Key etc., is not specifically limited herein.
In the above-described embodiments, central aortic blood pressure measurement device of the present invention is dynamic using peripheral arterial measuring instrument measurement periphery
The blood pressure waveform that arteries and veins changes over time obtains blood pressure measurement location of the blood flow from central aortic to peripheral arterial using processor
Propagation time, the final blood pressure waveform that central aortic is calculated using the blood pressure waveform and blood flow propagation time of peripheral arterial, meter
Calculation amount is less, need to only measure single peripheral arterial blood pressure waveform, and measurement difficulty is low, easy to use, can reduce measurement cost, and
Since the blood pressure waveform of the peripheral arterial of different human body real-time measurement and blood flow propagation time have differences, which is surveyed
The central aortic blood pressure waveform of amount can embody individual difference.
Referring to Fig. 7, Fig. 7 is the structural schematic diagram of central aortic blood pressure measurement device second embodiment of the present invention.Fig. 7 with
Fig. 6 structure is similar, and details are not described herein again, the difference is that, central aortic blood pressure measurement device 70 of the present invention further comprises:
Cardiographic detector 703 is connected to processor 702, the ECG signal changed over time for synchro measure.
Processor 702 is further used for utilizing the phase difference calculating between ECG signal and the blood pressure waveform of peripheral arterial
Blood flow is from central aortic to the propagation time of peripheral arterial blood pressure measurement location.
Specifically, in an application examples, cardiographic detector 703 is set in the cardia of person to be tested, to be tested
Peripheral arterial measuring instrument 701, the blood of ECG signal and peripheral arterial that synchro measure changes over time is arranged in person's finger position
Corrugating, processor 703 receive the above-mentioned blood pressure waveform and ECG signal changed over time, are based on photoelectricity volumetric measurement pulse
The principle of wave propagation time, the phase difference between calculating ECG signal and the blood pressure waveform of finger artery, to obtain blood flow
From the transmission time of central aortic Digital arteries blood pressure measurement location in one's hands, circular can refer to the side of step S121
Method is not repeated herein.Certainly, in other application example, the blood pressure waveform of other peripheral arterials can also be measured, is not done herein
It is specific to limit.
In the above-described embodiments, central aortic blood pressure measurement device of the present invention further using measurement ECG signal and
Blood pressure waveform calculates the propagation time of blood pressure measurement location of the blood flow from central aortic to peripheral arterial, finally utilizes peripheral arterial
Blood pressure waveform and the blood flow propagation time calculate the blood pressure waveform of central aortic, since the periphery of different human body real-time measurement is dynamic
The blood pressure waveform of arteries and veins and blood flow propagation time have differences, therefore the central aortic blood pressure waveform of the device measuring can embody
Individual difference, and calculation amount is less, need to only measure single peripheral arterial blood pressure waveform, measurement difficulty is low, and it is easy to use, it can
Reduce measurement cost.
Mode the above is only the implementation of the present invention is not intended to limit the scope of the invention, all to utilize this
Equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content, it is relevant to be applied directly or indirectly in other
Technical field is included within the scope of the present invention.
Claims (10)
1. a kind of central aortic blood pressure measuring method, which is characterized in that the described method includes:
Measure the blood pressure waveform of peripheral arterial changed over time；
Blood flow is obtained from central aortic to the propagation time of the blood pressure measurement location of the peripheral arterial；
The blood pressure waveform of the central aortic is calculated using the blood pressure waveform and the propagation time of the peripheral arterial.
2. the method according to claim 1, which is characterized in that the blood pressure waveform using the peripheral arterial and the biography
The step of blood pressure waveform of the central aortic is calculated between sowing time include:
The advancing wave and back wave of the blood pressure measurement location of the peripheral arterial are decomposed using the blood pressure waveform of the peripheral arterial；
The center is calculated using the advancing wave and back wave of the peripheral arterial blood pressure measurement location and the propagation time
The blood pressure waveform of artery.
3. method according to claim 2, which is characterized in that the advancing wave using the peripheral arterial blood pressure measurement location
The step of calculating the blood pressure waveform of the central aortic with back wave and the propagation time include:
The blood pressure waveform of the central aortic is calculated by following formula:
PC(t)=pDf(t+Δt)+pDb(t-Δt)；
Wherein, PCIt (t) is blood pressure of the central aortic in t moment, pDf(t+ Δ t) and pDb(t- Δ t) is the peripheral arterial
Blood pressure detecting position advancing wave and back wave respectively in the value of t+ Δ t and t- time Δt, Δ t is blood flow from the center
Artery to the peripheral arterial blood pressure measurement location propagation time.
4. method according to claim 2, which is characterized in that the blood pressure waveform using the peripheral arterial decomposes described outer
The step of advancing wave and back wave of the blood pressure measurement location of all arteries includes:
The advancing wave and back wave are decomposited by following formula:
Wherein, pDf(t) value for the advancing wave of the peripheral arterial blood pressure measurement location in t moment, pDb(t) dynamic for the periphery
Value of the back wave of arteries and veins blood pressure measurement location in t moment, PDIt (t) is blood of the peripheral arterial blood pressure measurement location in t moment
Pressure.
5. method according to claim 2, which is characterized in that
It is described measurement peripheral arterial the blood pressure waveform changed over time the step of include:
The blood pressure waveform changed over time when measuring the peripheral arterial closed state；
Measure the blood pressure waveform changed over time when the non-closed state of the peripheral arterial；
The blood pressure waveform using the peripheral arterial decomposes the advancing wave of the blood pressure measurement location of the peripheral arterial and anti-
The step of ejected wave includes:
The advancing wave and back wave are decomposited by following formula:
pDb(t)=PD2(t)-pDf(t)；
Wherein, pDf(t) value for the advancing wave of the peripheral arterial blood pressure measurement location in t moment, pDb(t) dynamic for the periphery
Value of the back wave of arteries and veins blood pressure measurement location in t moment, PD1(t) be the peripheral arterial closed state when blood pressure measurement location exist
The blood pressure of t moment；PD2(t) blood pressure of the blood pressure measurement location in t moment when closed state non-for the peripheral arterial.
6. the method according to claim 1, which is characterized in that
The blood pressure waveform for measuring the peripheral arterial changed over time further comprises:
The ECG signal that synchro measure changes over time；
The acquisition blood flow includes: from central aortic to the step of propagation time of the blood pressure measurement location of the peripheral arterial
Using the phase difference calculating blood flow between the ECG signal and the blood pressure waveform of the peripheral arterial from the center
Propagation time of the artery to the peripheral arterial blood pressure measurement location.
7. the method according to claim 1, which is characterized in that the acquisition blood flow is from central aortic to the blood of the peripheral arterial
Press measurement position propagation time the step of include:
Estimate the blood flow from central aortic to the propagation time of the blood pressure measurement location of the peripheral arterial using priori knowledge.
8. a kind of central aortic blood pressure measurement device, which is characterized in that the equipment includes:
Peripheral arterial measuring instrument, the blood pressure waveform changed over time for measuring peripheral arterial；
Processor connects the peripheral arterial measuring instrument, for obtaining blood flow from central aortic to the blood pressure of the peripheral arterial
The propagation time of measurement position calculates the central aortic using the blood pressure waveform and the propagation time of the peripheral arterial
Blood pressure waveform.
9. according to the equipment in claim 8, which is characterized in that the processor is further used for utilizing the peripheral arterial
Blood pressure waveform decomposites the advancing wave and back wave of the blood pressure measurement location of the peripheral arterial, utilizes the peripheral arterial blood pressure
The advancing wave and back wave of measurement position and the propagation time calculate the blood pressure waveform of the central aortic.
10. equipment according to claim 8, which is characterized in that further comprise: cardiographic detector, at any time for synchro measure
Between the ECG signal that changes；
The processor connects the cardiographic detector, is further used for utilizing the ECG signal and the peripheral arterial
Phase difference calculating blood flow between blood pressure waveform is from the central aortic to the propagation time of the arterial pressure measurement position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710369140.XA CN108937896B (en) | 2017-05-23 | 2017-05-23 | Central arterial blood pressure measuring method and equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710369140.XA CN108937896B (en) | 2017-05-23 | 2017-05-23 | Central arterial blood pressure measuring method and equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108937896A true CN108937896A (en) | 2018-12-07 |
| CN108937896B CN108937896B (en) | 2021-08-03 |
Family
ID=64493672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710369140.XA Active CN108937896B (en) | 2017-05-23 | 2017-05-23 | Central arterial blood pressure measuring method and equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108937896B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113143230A (en) * | 2021-05-11 | 2021-07-23 | 重庆理工大学 | Peripheral arterial blood pressure waveform reconstruction system |
Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010071429A (en) * | 1998-06-07 | 2001-07-28 | 추후제출 | Pressure applicator devices particularly useful for non-invasive detection of medical conditions |
| CN101309637A (en) * | 2005-11-22 | 2008-11-19 | 松下电工株式会社 | Apparatus for measuring biological data |
| US20110021929A1 (en) * | 2009-07-27 | 2011-01-27 | Nellcor Puritan Bennett Ireland | Systems and methods for continuous non-invasive blood pressure monitoring |
| CN102197996A (en) * | 2010-11-23 | 2011-09-28 | 中国科学院合肥物质科学研究院 | Method for obtaining pulse wave velocity of aorta by using pulse wave of radial artery |
| KR101069489B1 (en) * | 2009-04-30 | 2011-09-30 | 연세대학교 산학협력단 | Evaluation apparatus of peripheral blood vessel and blood flow state and method thereof |
| CN102499658A (en) * | 2011-11-08 | 2012-06-20 | 中国科学院深圳先进技术研究院 | Central blood pressure waveform reconstruction module and reconstruction method |
| US8313439B2 (en) * | 2009-03-20 | 2012-11-20 | Massachusetts Institute Of Technology | Calibration of pulse transit time measurements to arterial blood pressure using external arterial pressure applied along the pulse transit path |
| CN103429169A (en) * | 2011-01-21 | 2013-12-04 | 健资国际私人有限公司 | Apparatus and method for altering the arterial pulse waveform of a body |
| CN103479343A (en) * | 2013-09-27 | 2014-01-01 | 上海交通大学 | Central aortic pressure detection system and method based on oscillating sphygmomanometer signals |
| CN104414679A (en) * | 2013-09-04 | 2015-03-18 | 北京航空航天大学 | Method for determining peripheral pressure wave delay time in reconstruction of central arterial pressure |
| CN103284703B (en) * | 2013-06-18 | 2015-05-13 | 中国科学院合肥物质科学研究院 | Aortic pulse wave transfer time measuring method based on upper extremity artery information |
| CN105595979A (en) * | 2016-01-21 | 2016-05-25 | 中山大学 | Noninvasive and continuous blood pressure monitoring method and device based on pulse wave propagation time |
| TWI535416B (en) * | 2015-06-02 | 2016-06-01 | 國立中央大學 | Apparatus and method for noninvasive and cuffless blood pressure measurement |
| CN105725999A (en) * | 2016-01-26 | 2016-07-06 | 四川长虹电器股份有限公司 | Blood pressure measuring method based on pulse wave conduction |
| CN105748051A (en) * | 2016-02-18 | 2016-07-13 | 京东方科技集团股份有限公司 | Blood pressure measuring method and device |
| CN106333663A (en) * | 2016-10-20 | 2017-01-18 | 深圳欧德蒙科技有限公司 | Blood pressure monitoring method and device |
| CN106343990A (en) * | 2016-09-21 | 2017-01-25 | 中国矿业大学 | Finger-pressing sphygmomanometer and measuring method thereof |
| CN106413534A (en) * | 2015-08-08 | 2017-02-15 | 深圳先进技术研究院 | Blood-pressure continuous-measurement device, measurement model establishment method, and system |
| CN106618537A (en) * | 2016-12-21 | 2017-05-10 | 天津普仁万合信息技术有限公司 | Continuous dynamic blood pressure monitoring device and method based on pulse wave transit |
| CN108236459A (en) * | 2016-12-26 | 2018-07-03 | 深圳先进技术研究院 | A kind of central aortic blood pressure measuring method and system |
-
2017
- 2017-05-23 CN CN201710369140.XA patent/CN108937896B/en active Active
Patent Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010071429A (en) * | 1998-06-07 | 2001-07-28 | 추후제출 | Pressure applicator devices particularly useful for non-invasive detection of medical conditions |
| CN1286429C (en) * | 1998-06-07 | 2006-11-29 | 意塔玛医学(Cm)1997有限公司 | Pressure applicator devices particularly useful for non-invasive detection of medical conditions |
| CN101309637A (en) * | 2005-11-22 | 2008-11-19 | 松下电工株式会社 | Apparatus for measuring biological data |
| US8313439B2 (en) * | 2009-03-20 | 2012-11-20 | Massachusetts Institute Of Technology | Calibration of pulse transit time measurements to arterial blood pressure using external arterial pressure applied along the pulse transit path |
| KR101069489B1 (en) * | 2009-04-30 | 2011-09-30 | 연세대학교 산학협력단 | Evaluation apparatus of peripheral blood vessel and blood flow state and method thereof |
| US20110021929A1 (en) * | 2009-07-27 | 2011-01-27 | Nellcor Puritan Bennett Ireland | Systems and methods for continuous non-invasive blood pressure monitoring |
| CN102197996A (en) * | 2010-11-23 | 2011-09-28 | 中国科学院合肥物质科学研究院 | Method for obtaining pulse wave velocity of aorta by using pulse wave of radial artery |
| CN103429169A (en) * | 2011-01-21 | 2013-12-04 | 健资国际私人有限公司 | Apparatus and method for altering the arterial pulse waveform of a body |
| CN102499658A (en) * | 2011-11-08 | 2012-06-20 | 中国科学院深圳先进技术研究院 | Central blood pressure waveform reconstruction module and reconstruction method |
| CN103284703B (en) * | 2013-06-18 | 2015-05-13 | 中国科学院合肥物质科学研究院 | Aortic pulse wave transfer time measuring method based on upper extremity artery information |
| CN104414679A (en) * | 2013-09-04 | 2015-03-18 | 北京航空航天大学 | Method for determining peripheral pressure wave delay time in reconstruction of central arterial pressure |
| CN103479343A (en) * | 2013-09-27 | 2014-01-01 | 上海交通大学 | Central aortic pressure detection system and method based on oscillating sphygmomanometer signals |
| TWI535416B (en) * | 2015-06-02 | 2016-06-01 | 國立中央大學 | Apparatus and method for noninvasive and cuffless blood pressure measurement |
| CN106413534A (en) * | 2015-08-08 | 2017-02-15 | 深圳先进技术研究院 | Blood-pressure continuous-measurement device, measurement model establishment method, and system |
| CN105595979A (en) * | 2016-01-21 | 2016-05-25 | 中山大学 | Noninvasive and continuous blood pressure monitoring method and device based on pulse wave propagation time |
| CN105725999A (en) * | 2016-01-26 | 2016-07-06 | 四川长虹电器股份有限公司 | Blood pressure measuring method based on pulse wave conduction |
| CN105748051A (en) * | 2016-02-18 | 2016-07-13 | 京东方科技集团股份有限公司 | Blood pressure measuring method and device |
| CN106343990A (en) * | 2016-09-21 | 2017-01-25 | 中国矿业大学 | Finger-pressing sphygmomanometer and measuring method thereof |
| CN106333663A (en) * | 2016-10-20 | 2017-01-18 | 深圳欧德蒙科技有限公司 | Blood pressure monitoring method and device |
| CN106618537A (en) * | 2016-12-21 | 2017-05-10 | 天津普仁万合信息技术有限公司 | Continuous dynamic blood pressure monitoring device and method based on pulse wave transit |
| CN108236459A (en) * | 2016-12-26 | 2018-07-03 | 深圳先进技术研究院 | A kind of central aortic blood pressure measuring method and system |
Non-Patent Citations (1)
| Title |
|---|
| 蔡优飞: "基于两个外周血压重建中心动脉压的方法及系统关键技术的研究", 《中国优秀硕士学位论文全文数据库 信息科技辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113143230A (en) * | 2021-05-11 | 2021-07-23 | 重庆理工大学 | Peripheral arterial blood pressure waveform reconstruction system |
| CN113143230B (en) * | 2021-05-11 | 2022-05-20 | 重庆理工大学 | Peripheral arterial blood pressure waveform reconstruction system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108937896B (en) | 2021-08-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Khir et al. | Determination of wave speed and wave separation in the arteries | |
| CN103385702B (en) | A kind of non-invasive blood pressure continuous detection apparatus and method | |
| US10349838B2 (en) | Methods and apparatus for determining arterial pulse wave velocity | |
| US10709424B2 (en) | Method and system for cuff-less blood pressure (BP) measurement of a subject | |
| Proença et al. | Is pulse transit time a good indicator of blood pressure changes during short physical exercise in a young population? | |
| CN106821356B (en) | Cloud continuous BP measurement method and system based on Elman neural network | |
| CN108498089A (en) | A kind of noninvasive continuous BP measurement method based on deep neural network | |
| CN102499669B (en) | Heart parameter measuring method and device | |
| WO2018099425A1 (en) | Pulse detection module and blood pressure measurement device comprising same | |
| CN108366749A (en) | Ambulatory blood pressure and life physical sign monitoring device, system and method | |
| CN109512412B (en) | Central artery blood pressure measuring device | |
| US9119535B2 (en) | Blood pressure manometer and a method of calculating indices of atherosclerosis using the blood pressure manometer | |
| CN108523867A (en) | A kind of self calibration PPG non-invasive blood pressure measuring methods and system | |
| CN105578951A (en) | Blood pressure measurement device | |
| CN102688024A (en) | Blood pressure noninvasive measuring method | |
| Xu et al. | Improved pulse transit time estimation by system identification analysis of proximal and distal arterial waveforms | |
| CN105105734A (en) | Noninvasive continuous blood pressure measurement method, device and system based on heart sound signals | |
| Shi et al. | Neural network based real-time heart sound monitor using a wireless wearable wrist sensor | |
| CN109497981A (en) | A kind of Korotkoff's Sound blood pressure detector and its detection method with pulse wave detection | |
| CN103393415B (en) | The measuring method of continuous blood pressure change | |
| Joseph et al. | Arterial compliance probe for calibration free pulse pressure measurement | |
| CN104983412B (en) | A kind of central aortic systolic phase average normalized blood flow waveform model and the method that aortic pulse wave passing time is obtained based on it | |
| GB2552455A (en) | Blood monitoring | |
| Welkowitz et al. | Noninvasive estimation of cardiac output | |
| CN108937896A (en) | A kind of central aortic blood pressure measuring method and equipment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |