CN108853053B - Production method of iron dextran product capable of being rapidly disintegrated in pig oral cavity - Google Patents
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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Abstract
The invention discloses a production method of a dextran iron product capable of being rapidly disintegrated in a pig oral cavity, and relates to the technical field of pig breeding. The invention comprises the following steps: step 1, preparation and configuration of medicaments: adding the ingredients into iron dextran serving as a main material to prepare an inner core layer mixture solution for later use; taking pre-gelatinized starch and jujube powder as raw materials, adding ingredients and water, and uniformly stirring to obtain an outer-layer wrapping liquid for later use; using NaCl and CaCl2Preparing a mixed solution with the concentration of 1-5 wt% as a receiving solution for later use; step 2, package preparation: and (3) preparing and forming a granular iron dextran product by using a medicine coating device and using the medicine solution prepared in the step (1). The iron dextran product prepared by wrapping the iron dextran product is used for oral administration, can be directly placed in the oral cavity of a pig for subsidy, solves the problem that the pig is easy to generate stress reaction during the existing injection, and saves time and labor by oral administration of iron supplementation.
Description
Technical Field
The invention belongs to the technical field of pig breeding, and particularly relates to a production method of a dextran iron product capable of being rapidly disintegrated in a pig oral cavity.
Background
The iron dextran selenide injection is prepared by complexing iron hydroxide and dextran through an advanced process, preparing the complex with sodium selenite, filtering, and carrying out hot-pressing sterilization, and is mainly applied to prevention and treatment of selenium deficiency and iron deficiency anemia of piglets.
A large number of studies show that only about 50mg of iron is needed in a piglet body at birth, 7 mg of iron is needed every day to meet the growth requirement of the piglet, and the piglet only can obtain 1 mg of iron from sow breast milk every day, so that after the piglet is born for 7 days, if the iron is not supplemented, the piglet cannot meet the growth requirement to generate iron-deficiency anemia, and the growth retardation, weight loss, low disease resistance, high mortality and the like are caused. Therefore, piglets must be supplemented with enough iron to meet their needs throughout lactation 1-4 days after birth. At present, the better iron supplement for piglets recognized at home and abroad is iron dextran injection, and 1ml of the iron dextran injection with the iron content of 150mg/ml is injected into piglets at one time in a muscle manner within 1-4 days after birth, so that the iron requirement of piglets in the whole lactation period can be met, the iron deficiency anemia of the piglets is prevented, the growth of the piglets is promoted, and the death rate of the piglets is reduced.
However, when the injection is used for intramuscular injection in the prior art, the stress reaction of pigs is easy to generate by the injection, and the injection is troublesome and labor-consuming and inconvenient to operate.
Disclosure of Invention
The invention aims to provide a production method of a dextran iron product capable of being rapidly disintegrated in a pig oral cavity.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention relates to a method for producing a dextran iron product capable of being rapidly disintegrated in a pig oral cavity, which comprises the following steps:
step 1, preparation and configuration of medicaments: adding the ingredients into iron dextran serving as a main material to prepare an inner core layer mixture solution for later use; taking pre-gelatinized starch and jujube powder as raw materials, adding ingredients and water, and uniformly stirring to obtain an outer-layer wrapping liquid for later use; using NaCl and CaCl2Preparing a mixed solution with the concentration of 1-5 wt% as a receiving solution for later use;
step 2, package preparation: and (3) preparing and forming a granular iron dextran product by using a medicine coating device and using the medicine solution prepared in the step (1).
Further, the ingredients comprise sodium selenite, emulsifier, tween, glycerol, dextrin, lactose, vitamin B1 and vitamin B6.
Further, the medicinal components in the inner core layer mixture solution comprise 1-10% of iron dextran, 1-20% of vitamin B1, 1-5% of vitamin B6, 1-10% of sodium selenite, 10-50% of dextrin, 10-50% of lactose, 1-10% of emulsifier, 1-10% of Tween and 1-10% of glycerol; the mass concentration of the medicine components in the inner core layer mixture solution is 5-15%.
Further, the particle size of the jujube powder is between 150 meshes and 300 meshes.
Further, the ingredients comprise sodium alginate, sodium carboxymethylcellulose and acacia gum.
Further, the outer-layer wrapping liquid is prepared from pregelatinized starch, date powder and sodium alginate, wherein the dosage ratio of the pregelatinized starch, the date powder and the sodium alginate is 1-10: 1-5: 1-4; the concentration of the medicinal components in the outer layer wrapping liquid is 10-20%.
Further, the outer-layer wrapping liquid is prepared from pregelatinized starch, date powder, sodium carboxymethylcellulose and acacia; the dosage ratio of the pregelatinized starch, the date powder, the sodium carboxymethylcellulose and the acacia is 1-10: 1-5: 0.5-3: 0.5-3; the concentration of the medicinal components in the outer layer wrapping liquid is 10-20%.
Further, the configuration of the outer layer wrapping liquid specifically includes: heating distilled water to 45-50 deg.C, adding fructus Jujubae powder under stirring, cooling to room temperature, adding pregelatinized starch and adjuvants, and stirring to obtain outer layer wrapping liquid.
Further, the outer layer wrapping liquid also contains a disintegrating agent and a flavoring agent; the mass concentrations of the disintegrant and the flavoring agent are 0.5-2% and 0.5-3%, respectively.
Further, the disintegrating agent is any one or more of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose and sodium carboxymethyl cellulose; the flavoring agent is one or more of aspartame, glycyrrhizin, citric acid and vanillin.
Further, the drug wrapping process in step 2 comprises:
fluid focusing: injecting the outer layer wrapping liquid and the inner layer polymer solution by a double-flux micro-injection pump; driving by gas source gas to enable the polymer solution and the outer-layer wrapping liquid to be intersected and flow out from the mutual intersection point so as to form microbeads which flow into the receiving liquid tank;
curing the microbeads: the microbeads are rapidly solidified in the receiving liquid tank to form microparticles.
The invention has the following beneficial effects:
1. the iron dextran product prepared by wrapping the iron dextran product is used for oral administration, can be directly placed in the oral cavity of a pig for subsidy, solves the problem that the pig is easy to generate stress reaction during the existing injection, and saves time and labor by oral administration of iron supplementation;
2. according to the invention, the outer-layer wrapping liquid is prepared by taking the pre-gelatinized starch and the jujube powder as main materials, and when the tablet is put into a pig oral cavity, amylase in the pig oral cavity can quickly dissolve the pre-gelatinized starch, so that a mixture of an inner core layer is quickly separated out; meanwhile, the jujube powder contains a large amount of vitamin C, and the absorption and conversion of the pig on the iron dextran can be enhanced by utilizing the vitamin C;
3. the vitamin B1 and the vitamin B6 are added to reduce the sensitivity of sensory neurons, so that the stress response of pigs is reduced.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Detailed Description
Example 1
A method for producing a dextran iron product capable of being rapidly disintegrated in a pig oral cavity comprises the following steps:
step 1, preparation and configuration of medicaments: adding the ingredients into iron dextran serving as a main material to prepare an inner core layer mixture solution for later use; taking pre-gelatinized starch and jujube powder as raw materials, adding ingredients and water, and uniformly stirring to obtain an outer-layer wrapping liquid for later use; using NaCl and CaCl2Preparing a mixed solution with the concentration of 2 wt% as a receiving solution for later use;
step 2, package preparation: and (3) preparing and forming a granular iron dextran product by using a medicine coating device and using the medicine solution prepared in the step (1).
Wherein the ingredients comprise sodium selenite, emulsifier, tween, glycerol, dextrin, lactose, vitamin B1 and vitamin B6.
Wherein, the medicinal components in the inner core layer mixture solution comprise 5% of iron dextran, 10% of vitamin B1, 2% of vitamin B6, 8% of sodium selenite, 30% of dextrin, 30% of lactose, 5% of emulsifier, 5% of tween and 5% of glycerol; the mass concentration of the medicine components in the mixture solution of the inner core layer is 10 percent.
Wherein the particle size of the jujube powder is between 150-300 meshes.
Wherein the ingredients comprise sodium alginate, sodium carboxymethylcellulose and acacia.
Wherein the outer layer wrapping liquid is prepared from pregelatinized starch, date powder and sodium alginate, and the dosage ratio of the pregelatinized starch, the date powder and the sodium alginate is 5:2: 1; the concentration of the drug components in the outer wrapping liquid is 15 percent.
Wherein, the configuration of outer layer wrapping liquid specifically includes: heating distilled water to 45-50 deg.C, adding fructus Jujubae powder under stirring, cooling to room temperature, adding pregelatinized starch and adjuvants, and stirring to obtain outer layer wrapping liquid.
Wherein the outer layer wrapping liquid also contains disintegrating agent and correctant; the mass concentrations of the disintegrant and the flavoring agent are respectively 1% and 1%.
Wherein the disintegrant is sodium carboxymethyl starch; the flavoring agent is aspartame.
Wherein, the medicine wrapping process in the step 2 comprises the following steps:
fluid focusing: injecting the outer layer wrapping liquid and the inner layer polymer solution by a double-flux micro-injection pump; driving by gas source gas to enable the polymer solution and the outer-layer wrapping liquid to be intersected and flow out from the mutual intersection point so as to form microbeads which flow into the receiving liquid tank;
curing the microbeads: the microbeads are rapidly solidified in the receiving liquid tank to form microparticles.
Example 2
A method for producing a dextran iron product capable of being rapidly disintegrated in a pig oral cavity comprises the following steps:
step 1, preparation and configuration of medicaments: adding the ingredients into iron dextran serving as a main material to prepare an inner core layer mixture solution for later use; taking pre-gelatinized starch and jujube powder as raw materials, adding ingredients and water, and uniformly stirring to obtain an outer-layer wrapping liquid for later use; using NaCl and CaCl2Preparing a mixed solution with the concentration of 4 wt% as a receiving solution for later use;
step 2, package preparation: and (3) preparing and forming a granular iron dextran product by using a medicine coating device and using the medicine solution prepared in the step (1).
Wherein the ingredients comprise sodium selenite, emulsifier, tween, glycerol, dextrin, lactose, vitamin B1 and vitamin B6.
Wherein, the medicinal components in the inner core layer mixture solution comprise 8% of iron dextran, 12% of vitamin B1, 3% of vitamin B6, 7% of sodium selenite, 15% of dextrin, 25% of lactose, 2% of emulsifier, 8% of tween and 8% of glycerol; the mass concentration of the medicine components in the inner core layer mixture solution is 12%.
Wherein the particle size of the jujube powder is between 150-300 meshes.
Wherein the ingredients comprise sodium alginate, sodium carboxymethylcellulose and acacia.
Wherein the outer layer wrapping liquid is prepared from pregelatinized starch, jujube powder, sodium carboxymethylcellulose and acacia; the dosage ratio of the pregelatinized starch, the date powder, the sodium carboxymethylcellulose and the acacia is 8: 3: 1: 2; the concentration of the drug components in the outer wrapping liquid is 12 percent.
Wherein, the configuration of outer layer wrapping liquid specifically includes: heating distilled water to 45-50 deg.C, adding fructus Jujubae powder under stirring, cooling to room temperature, adding pregelatinized starch and adjuvants, and stirring to obtain outer layer wrapping liquid.
Wherein the outer layer wrapping liquid also contains disintegrating agent and correctant; the mass concentrations of the disintegrant and the flavoring agent are respectively 2% and 3%.
Wherein the disintegrant is sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose; the correctant is citric acid.
Wherein, the medicine wrapping process in the step 2 comprises the following steps:
fluid focusing: injecting the outer layer wrapping liquid and the inner layer polymer solution by a double-flux micro-injection pump; driving by gas source gas to enable the polymer solution and the outer-layer wrapping liquid to be intersected and flow out from the mutual intersection point so as to form microbeads which flow into the receiving liquid tank;
curing the microbeads: the microbeads are rapidly solidified in the receiving liquid tank to form microparticles.
Example 3
Piglet iron deficiency test
The target is as follows: 30 piglets of 10 days old are divided into A, B, C groups with 10 piglets in each group;
group A: feeding with conventional non-iron supplement feed every day,
group B: feeding with conventional iron supplementing feed every day,
group C: feeding the dextran iron product by using the conventional non-iron supplement feed every day and feeding 10-20g of the dextran iron product prepared by the invention every day;
the hemoglobin content in the blood of piglets fed for 4 days, 10 days, 15 days and 20 days is respectively detected and counted, and the statistical result is shown in the table I:
as shown in the first table, the iron-dextran product prepared by the invention has good iron supplementing effect on piglets when being used for feeding piglets.
Example 4
Iron supplement experiment for piglets
The target is as follows: 30 piglets of 10 days old are divided into V, W, X, Y, Z groups with 6 piglets;
group V: feeding the iron-dextran product by using the conventional non-iron-supplementation feed every day and simultaneously feeding 5g of the iron-dextran product prepared by the invention every day,
and group W: feeding the iron-dextran product by using the conventional non-iron-supplementation feed every day and feeding 10g of the iron-dextran product prepared by the invention every day,
group X: feeding with the conventional non-iron supplement feed every day, and feeding 15g of iron dextran product prepared by the invention every day,
group Y: the iron dextran product prepared by the invention is fed by using the conventional non-iron supplement feed every day and is also fed by 20g every day,
group Z, feeding the dextran iron product prepared by the invention by using the conventional non-iron supplement feed every day and simultaneously feeding 25g of the dextran iron product every day;
the hemoglobin content in the blood of piglets fed for 4 days, 10 days, 15 days and 20 days is respectively detected and counted, and the statistical result is shown in the table two:
as shown in the second table, when the iron dextran product prepared by the invention is used for raising piglets, the best raising amount is 10-20g, and the iron supplementing effect is poor when the raising amount is less than 5 g/day; the utilization rate of the iron supplement product exceeding 25 g/day is low, and waste is easy to cause.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (8)
1. A production method of a dextran iron product capable of being rapidly disintegrated in a pig oral cavity is characterized by comprising the following steps:
step 1, preparation and configuration of medicaments: adding the ingredients into iron dextran serving as a main material to prepare an inner core layer mixture solution for later use; the ingredients of the inner core comprise sodium selenite, emulsifier, tween, glycerol, dextrin, lactose, vitamin B1 and vitamin B6; taking pre-gelatinized starch and jujube powder as raw materials, adding ingredients and water, and uniformly stirring to obtain an outer-layer wrapping liquid for later use; the outer layer ingredient is one or more of sodium alginate, sodium carboxymethylcellulose and acacia; using NaCl and CaCl2Preparing a mixed solution with the concentration of 1-5 wt% as a receiving solution for later use;
step 2, package preparation: preparing and forming a granular iron dextran product by using the medicine solution prepared in the step 1 by using a medicine wrapping instrument;
the medicine packaging process comprises the following steps:
fluid focusing: injecting the mixture solution of the outer layer wrapping liquid and the inner core layer by a double-flux micro-injection pump; driving by gas source gas to enable the mixture solution of the inner core layer and the wrapping liquid of the outer layer to be intersected and flow out from the mutual intersection point so as to form microbeads which flow into the liquid receiving tank;
curing the microbeads: the microbeads are rapidly solidified in the receiving liquid tank to form microparticles.
2. The method for producing a rapidly disintegrating iron dextran product in porcine oral cavity according to claim 1, wherein the pharmaceutical components in the inner core layer mixture solution comprise 1-10% of iron dextran, 1-20% of vitamin B1, 1-5% of vitamin B6, 1-10% of sodium selenite, 10-50% of dextrin, 10-50% of lactose, 1-10% of emulsifier, 1-10% of Tween, 1-10% of glycerol; the mass concentration of the medicinal components in the inner core layer mixture solution is 5-15%.
3. The method for producing a rapidly disintegrating iron dextran preparation in pig oral cavity as claimed in claim 1, wherein said jujube powder has a particle size of 150-300 mesh.
4. The method for producing a ferric dextran product capable of being rapidly disintegrated in an oral cavity of a pig according to claim 1, wherein the outer coating liquid is prepared from pregelatinized starch, date powder and sodium alginate, and the dosage ratio of the pregelatinized starch, the date powder and the sodium alginate is 1-10: 1-5: 1-4; the concentration of the medicinal components in the outer layer wrapping liquid is 10-20%.
5. The method for producing a rapidly disintegrating iron dextran preparation in the porcine oral cavity according to claim 1, wherein the outer coating solution is prepared from pregelatinized starch, jujube powder, sodium carboxymethylcellulose and acacia; the dosage ratio of the pregelatinized starch, the date powder, the sodium carboxymethylcellulose and the acacia is 1-10: 1-5: 0.5-3: 0.5-3; the concentration of the medicinal components in the outer layer wrapping liquid is 10-20%.
6. The method for producing a rapidly disintegrating iron dextran product in a pig oral cavity according to claim 1, wherein the preparation of the outer coating solution specifically comprises: heating distilled water to 45-50 deg.C, adding fructus Jujubae powder under stirring, cooling to room temperature, adding pregelatinized starch and adjuvants, and stirring to obtain outer layer wrapping liquid.
7. The method for producing a rapidly disintegrating iron dextran preparation in porcine oral cavity according to claim 1, wherein said outer coating solution further comprises a disintegrant and a flavoring agent; the mass concentrations of the disintegrant and the flavoring agent are 0.5-2% and 0.5-3%, respectively.
8. The method for producing a rapidly disintegrating iron dextran preparation in the porcine oral cavity according to claim 7, wherein the disintegrating agent is any one or more of sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, cross-linked sodium carboxymethyl cellulose, and sodium carboxymethyl cellulose; the flavoring agent is one or more of aspartame, glycyrrhizin, citric acid and vanillin.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861203A (en) * | 2007-10-12 | 2010-10-13 | Fio公司 | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
| CN102397288A (en) * | 2010-09-13 | 2012-04-04 | 瑞普（天津）生物药业有限公司 | Iron-dextrin composition without stress reaction |
| WO2013075248A1 (en) * | 2011-11-23 | 2013-05-30 | The Governing Council Of The University Of Toronto | Devices and methods for producing planar polymeric materials using microfluidics |
| CN106306423A (en) * | 2016-08-19 | 2017-01-11 | 安佑生物科技集团股份有限公司 | Oral iron supplement for livestock and preparation method thereof |
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2018
- 2018-09-11 CN CN201811056598.0A patent/CN108853053B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101861203A (en) * | 2007-10-12 | 2010-10-13 | Fio公司 | Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto |
| CN102397288A (en) * | 2010-09-13 | 2012-04-04 | 瑞普（天津）生物药业有限公司 | Iron-dextrin composition without stress reaction |
| WO2013075248A1 (en) * | 2011-11-23 | 2013-05-30 | The Governing Council Of The University Of Toronto | Devices and methods for producing planar polymeric materials using microfluidics |
| CN106306423A (en) * | 2016-08-19 | 2017-01-11 | 安佑生物科技集团股份有限公司 | Oral iron supplement for livestock and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 微量元素在猪生长中的作用与影响;胡吉耘;《贵州畜牧兽医》;20051231;第29卷(第4期);第28页 * |
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