CN108744322B - Treatment equipment for asthenozoospermia - Google Patents

Treatment equipment for asthenozoospermia Download PDF

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Publication number
CN108744322B
CN108744322B CN201810743118.1A CN201810743118A CN108744322B CN 108744322 B CN108744322 B CN 108744322B CN 201810743118 A CN201810743118 A CN 201810743118A CN 108744322 B CN108744322 B CN 108744322B
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treatment
shock wave
generating unit
ultrasonic
probe
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CN108744322A (en
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白志明
辛钟成
夏术阶
吕福泰
林桂亭
郭应禄
郭矛
林茂繁
鞠胜
李�杰
李洪忠
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Beijing Wanbeili Medical Instrument Co ltd
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Beijing Wanbeili Medical Instrument Co ltd
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Priority to PCT/CN2019/095071 priority patent/WO2020011125A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N7/02Localised ultrasound hyperthermia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0004Applications of ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0078Ultrasound therapy with multiple treatment transducers

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

The invention relates to a weak sperm disease treatment device, comprising: the ultrasonic wave generating unit (1), the shock wave generating unit (2) and the treatment probes (3, 3 '), wherein the ultrasonic wave generating unit (1) and the shock wave generating unit (2) are operatively coupled with the treatment probes (3, 3 '), and can selectively emit therapeutic ultrasonic waves and/or therapeutic shock waves to the treatment site of the asthenozoospermia through the treatment probes (3, 3 '). The invention adopts an in-vitro treatment mode that the treatment probe selectively transmits the ultrasonic waves for treatment and/or the shock waves for treatment to the treatment part of the asthenozoospermia of the human body, utilizes the beneficial biological effect and physical effect brought by the ultrasonic waves and the shock waves to improve the quantity of the sperm which move forward in the semen and the forward movement capacity of the sperm, and improves the whole vitality of the sperm, thereby achieving the effect of treating the male infertility caused by the asthenospermia, and having convenient use and obvious treatment effect.

Description

Treatment equipment for asthenozoospermia
Technical Field
The invention relates to the field of medical equipment, in particular to weak sperm disease treatment equipment.
Background
The movement function or the movement capability of the sperms is directly related to reproduction of human beings, and only the sperms which normally do forward movement can ensure that the sperms reach the ampulla of the oviduct and are combined with the ovum to form fertilized eggs. The normal ex-vivo sperm, prior to semen liquefaction, is restricted in its movement and exhibits good movement ability once semen is liquefied. Fertilization is also not possible if the sperm cannot swim to the location of the ovum within an optimal time because of factors affecting sperm motility, particularly forward movement. Moreover, if the sperm is in the vagina for too long, the acidic environment within the vagina may shorten the sperm survival time.
According to domestic literature reports, male infertility caused by semen abnormality is 70% -80%, and semen abnormality comprises azoospermia, oligospermia, necrospermia, low sperm motility, non-liquefaction of semen and the like. Sperm may be graded as A, B, C, D four according to their motility. The A-level sperms are sperms which move forward quickly and move well, the B-level sperms are sperms which move forward slowly, the moving direction can be changed after the forward movement, the general sperms move actively, the C-level sperms are sperms which move in situ in a peristaltic or rotary mode, and the D-level sperms are sperms which do not move in situ and possibly are dead sperms. Asthenospermia (assospermia) refers to a condition in which less than 50% of the sperm (class a and B) move forward or less than 25% of the sperm move class a in a semen parameter, also known as hypomotility.
The causes of asthenozoospermia are numerous, including infections, semen dyscrasias, immune factors, endocrine factors, kartagener's syndrome, chromosomal abnormalities, varicoceles, and living factors. The treatment is generally Western medicine, chinese medicine or combination of Chinese and Western medicine. Western medicine treatment comprises general treatment, etiology treatment, hormone therapy, urokinase injection (uPA) and the like, and traditional Chinese medicine treatment mainly comprises traditional Chinese medicine treatment. The existing treatment methods have longer treatment period, more complex treatment process and limited treatment effect, and in addition, the drug treatment often has certain side effects.
Disclosure of Invention
The invention aims to provide a weak sperm disease treatment device which can effectively improve the whole activity of sperm so as to treat male infertility caused by weak sperm disease.
To achieve the above object, the present invention provides a weak sperm disease treatment apparatus comprising: the ultrasonic wave generating unit and the shock wave generating unit are operatively coupled with the treatment probe, and can selectively send therapeutic ultrasonic waves and/or therapeutic shock waves to the treatment site of the asthenozoospermia through the treatment probe.
Further, the therapeutic probe is a single therapeutic probe, and can emit therapeutic ultrasonic waves and therapeutic shock waves to the weak-sperm therapeutic part.
Further, the therapeutic probe comprises an ultrasonic shock wave generator which is respectively and operably coupled with the therapeutic probe, the ultrasonic wave generating unit and the shock wave generating unit, and can combine therapeutic ultrasonic waves and therapeutic shock waves into ultrasonic shock waves and send the ultrasonic shock waves to the treatment position of the asthenozoospermia through the therapeutic probe.
Further, the treatment probe is a single treatment probe, and can independently emit therapeutic ultrasonic waves or therapeutic shock waves, or the treatment probe comprises a plurality of independent treatment probes which are respectively coupled with the ultrasonic wave generation unit and the shock wave generation unit.
Further, the ultrasonic frequency range of the low-intensity pulse ultrasonic wave adopted by the ultrasonic generating unit is 1-2 MHz, and the sound intensity range is 0.05-3W/cm 2
Further, the ultrasonic frequency range adopted by the ultrasonic generating unit is 1.5-1.7 MHz.
Further, the shock wave frequency range adopted by the shock wave generating unit is 1-6 Hz, and the energy range is 0.01-0.7 mJ/mm 2
Further, the method further comprises the following steps: and a control unit which is connected with the ultrasonic wave generating unit and the shock wave generating unit in a signal way and can respectively adjust the parameters of the therapeutic ultrasonic wave output by the ultrasonic wave generating unit and/or the therapeutic shock wave output by the shock wave generating unit.
Further, the method further comprises the following steps: the detection unit is arranged at the end part of the treatment probe and is in signal connection with the control unit, so that the tissue state parameters of the treatment part of the asthenozoospermia can be detected and transmitted to the control unit, and the control unit can control the ultrasonic wave generation unit and/or the shock wave generation unit according to the detected result of the detection unit.
Further, the method further comprises the following steps: and the parameter storage unit is in signal connection with the control unit and is used for storing a plurality of tissue state parameters corresponding to the treatment positions of the asthenozoospermia, and the control unit can inquire the parameter storage unit according to the selection instruction of the treatment positions of the asthenospermia and control the ultrasonic wave generation unit and/or the shock wave generation unit according to the inquiry result.
Further, the method further comprises the following steps: the control unit is used for controlling the ultrasonic wave generation unit and/or the shock wave generation unit according to the adjustment instruction received by the control panel.
Further, the method further comprises the following steps: a probe adjustment mechanism is operatively coupled to the treatment probe and is capable of adjusting a movement position and an emission angle of the treatment probe.
Further, the probe adjusting mechanism comprises a mechanical arm, the treatment probe is mounted at the end part of the mechanical arm, the weak-sperm disease treatment equipment further comprises a control unit, the control unit is respectively connected with the mechanical arm and the treatment probe in a signal mode, the mechanical arm can be controlled according to the weak-sperm disease treatment part to drive the treatment probe to move to the corresponding position of the weak-sperm disease treatment part, and the angle of the treatment probe is adjusted.
Further, the ultrasonic wave generating unit further comprises a first adjusting lens which is connected with the control unit in a signal manner and used for adjusting the focusing type of the therapeutic ultrasonic wave output by the ultrasonic wave generating unit.
Further, the shock wave generating unit further comprises a second adjusting lens which is connected with the control unit in a signal manner and is used for adjusting the focusing type of the therapeutic shock wave output by the shock wave generating unit.
Further, the focusing type includes one of plane waves, scattered waves, focused waves, and semi-focused waves.
Based on the technical scheme, the invention adopts an in-vitro treatment mode that the treatment probe selectively transmits the treatment ultrasonic waves generated by the ultrasonic wave generating unit and/or the treatment shock waves generated by the shock wave generating unit to the treatment part of the asthenozoospermia of the human body, utilizes the beneficial biological effects and physical effects brought by the ultrasonic waves and the shock waves to improve the number of sperm moving forward in the semen and the forward movement capacity of the sperm, and improves the overall activity of the sperm, thereby achieving the effect of treating the male infertility caused by the asthenospermia, and has convenient use and obvious treatment effect.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiments of the invention and together with the description serve to explain the invention and do not constitute a limitation on the invention. In the drawings:
fig. 1 is a schematic structural diagram of a first embodiment of the asthenozoospermia treatment apparatus of the present invention.
Fig. 2 is a schematic structural diagram of a second embodiment of the asthenozoospermia treatment apparatus of the present invention.
Fig. 3 is a schematic structural view of a third embodiment of the asthenozoospermia treatment apparatus according to the present invention.
Fig. 4 is a schematic structural view of a fourth embodiment of the asthenozoospermia treatment apparatus of the present invention.
Fig. 5 is a schematic structural diagram of a fifth embodiment of the oligospermia treatment device according to the present invention.
Fig. 6 is a schematic structural view of a sixth embodiment of the oligospermia treatment device according to the present invention.
Detailed Description
The technical scheme of the invention is further described in detail through the drawings and the embodiments.
Fig. 1 is a schematic structural diagram of a first embodiment of the asthenozoospermia treatment apparatus according to the present invention. In this embodiment, the oligospermia treatment apparatus includes: an ultrasonic wave generating unit 1, a shock wave generating unit 2 and treatment probes 3,3', wherein the ultrasonic wave generating unit 1 and the shock wave generating unit 2 are operatively coupled with the treatment probes 3,3', and can selectively send therapeutic ultrasonic waves and/or therapeutic shock waves to the treatment site of asthenozoospermia through the treatment probes 3,3 '.
The ultrasound generating unit 1 may comprise an ultrasound excitation source, which generates therapeutic ultrasound waves that may transmit acoustic energy to the target tissue to cause a corresponding biological effect. From a physical point of view, ultrasound is a form of mechanical energy with high frequency pressure waves (1-12 MHz), which are used to induce biochemical changes at the cellular and molecular level by micro-mechanical pressure of pressure waves acting on human tissue. Therefore, when therapeutic ultrasound is emitted to a treatment site for asthenozoospermia (for example, testis or epididymis of adult male) by the therapeutic probe 3, the number of sperm in forward movement and the forward movement ability of sperm in semen can be effectively improved.
The shock wave generating unit 2 may include a shock wave driver, and the generated therapeutic shock wave may pass the shock wave through the body fluid and tissue of the human body to reach the affected part, and when the shock wave enters the human body, the medium (such as fat, tendon, ligament, and other soft tissue, bone tissue, etc.) and the corresponding acoustic impedance contacted by the shock wave are different, and the interface positions of the tissues with different acoustic impedances generate different mechanical stresses, which are represented by different tensile stresses and compressive stresses generated on the tissues. Wherein, the tensile stress can induce the loosening among tissues to promote microcirculation, while the compressive stress can promote the elastic deformation of cells to increase the oxygen uptake of the cells. In addition, the negative band at the tail of the pulse of the shock wave can cause cavitation effect, namely when the pressure applied to the fluid dynamic field is lower than the saturated vapor pressure of the liquid, molecules in the liquid can enter cavitation reaction nuclei and expand into an observable size. Cavitation effect is favorable for dredging occluded fine blood vessels and loosening the adhesion of joint soft tissues. The number of sperm moving forward in semen and the forward movement capacity of sperm can be effectively improved by utilizing the therapeutic effect of therapeutic shock waves.
In addition to the implementation principle, there are also certain differences in the therapeutic actions and side effects of many properties of therapeutic ultrasound waves and therapeutic shock waves (e.g. energy concentration, penetration, thermal effects, etc.). In this embodiment, the ultrasonic wave generating unit 1 and the shock wave generating unit 2 are both operatively coupled to the therapeutic probes 3,3', and the therapeutic ultrasonic wave generating unit 1 alone or the shock wave generating unit 2 alone or the ultrasonic wave generating unit 1 and the shock wave generating unit 2 together can be selected to emit therapeutic ultrasonic waves and therapeutic shock waves to the treatment site of asthenozoospermia according to the therapeutic requirements and the characteristics of therapeutic waves when the therapeutic probe is used by a patient or a therapist. When the ultrasonic wave generation unit 1 and the shock wave generation unit 2 are used in combination, the therapeutic ultrasonic wave and the therapeutic shock wave may be simultaneously or sequentially rotated.
The ultrasonic wave generating unit 1 and the shock wave generating unit 2 may be at least partially disposed inside the equipment cabinet, and may employ an upper computer part (e.g., a computer, a micro industrial personal computer, and/or an intelligent terminal, etc.) as a control unit to realize a control function. Electrical components such as power supplies may also be included in the equipment cabinet.
In the present embodiment, the ultrasonic frequency range of the low-intensity pulsed ultrasonic wave employed by the ultrasonic wave generating unit 1 is preferably 1 to 2MHz, and more preferably 1.5 to 1.7MHz. Within the preferable and more preferable ranges, not only can the treatment requirements be satisfied, but also the side effects caused by the ultrasonic waves can be reduced. Correspondingly, the sound intensity is preferably in the range of 0.05 to 3W/cm 2 . For the shock wave generating unit 2, it is possible to employ other shock wave frequency ranges of preferably 1 to 6Hz, and energy ranges of preferably 0.01 to 0.7mJ/mm 2 . Within the preferred and more preferred ranges, not only can the therapeutic requirements be met, but also the side effects caused by the shock waves can be reduced.
In fig. 1, the treatment probe 3,3' comprises a plurality of independent treatment probes, coupled to the ultrasound generating unit 1 and said shock wave generating unit 2, respectively. And as shown in fig. 2, a schematic structural diagram of a second embodiment of the asthenozoospermia treatment apparatus of the present invention is shown. In contrast to the previous embodiment, the treatment probe 3 of the present embodiment is a single treatment probe, and can emit treatment ultrasonic waves or treatment shock waves individually as needed.
Considering that there are certain side effects of both ultrasound and shock wave therapy, for example, the thermal effects of ultrasound can cause local temperature rise in tissues, which in turn can lead to changes in the activity of some enzymes that are very temperature sensitive (e.g., matrix metalloproteinase-1 and collagenase, etc.), leading to enzyme denaturation. Both ultrasonic waves and therapeutic waves can generate cavitation effects, and when transient cavitation occurs, adverse changes of biological functions of organism tissues can be caused, for example, damage to cell integrity and the like is caused, and further damage to capillaries and the like is caused, so that bleeding, scars, even nerve damage and the like are caused. That is, when an ultrasonic wave or a shock wave exceeding a certain energy is used for treating the tissues of the human body, a great degree of side effects may be brought to the human body, and if the energy is low, the therapeutic effect may be limited. In order to further improve the therapeutic effect and to improve the effect of side effects, the therapeutic probe 3 in the form of a single therapeutic probe can emit therapeutic ultrasonic waves or therapeutic shock waves alone, and can also emit therapeutic ultrasonic waves and therapeutic shock waves combined to the site of treatment of asthenozoospermia. The ultrasonic shock wave is a combination wave formed by superposition and combination of therapeutic ultrasonic waves and therapeutic shock waves. Under the same energy condition, the ultrasonic shock wave is adopted for treatment, so that the energy of each of the ultrasonic wave for treatment and the shock wave for treatment can be reduced to reduce side effects, and the difference of the two treatment waves in treatment effect is fully utilized, thereby achieving better treatment effect on male infertility caused by asthenozoospermia.
Fig. 3 is a schematic structural diagram of a third embodiment of the asthenozoospermia treatment apparatus according to the present invention. Compared with the previous embodiment, the present embodiment further includes an ultrasonic shock wave generator 4. The ultrasonic shock wave generator 4 is operatively coupled to the treatment probe 3, the ultrasonic wave generation unit 1 and the shock wave generation unit 2, respectively, and is capable of combining the therapeutic ultrasonic wave and the therapeutic shock wave into an ultrasonic shock wave and emitting the ultrasonic shock wave to the treatment site of asthenozoospermia through the treatment probe 3. The ultrasonic shock wave generator 4 may be added to the first embodiment, and the ultrasonic shock wave may be emitted by using either one of the treatment probes 3 and 3' or a new treatment probe.
Fig. 4 is a schematic structural view of a fourth embodiment of the asthenozoospermia treatment apparatus according to the present invention. Compared to the second embodiment, the present embodiment further includes a control unit 5. The control unit 5 is connected to the ultrasonic wave generation unit 1 and the shock wave generation unit 2 in a signal manner, and can adjust parameters of the therapeutic ultrasonic wave output from the ultrasonic wave generation unit 1 and/or the therapeutic shock wave output from the shock wave generation unit 2. The parameters here may include the ultrasound frequency, intensity, etc. of the therapeutic ultrasound waves, as well as the frequency, energy level, etc. of the therapeutic shock waves.
In addition to the above parameters, parameters such as the focusing mode and the focusing depth of the ultrasonic wave and the shock wave can be adjusted as needed. Accordingly, in some embodiments, the ultrasound generating unit 1 further comprises a first adjusting lens, which is in signal connection with the control unit 5, for adjusting the type of therapeutic ultrasound outputted by the ultrasound generating unit 1. In other embodiments, the shock wave generating unit 2 further comprises a second adjusting lens, which is in signal connection with the control unit 5, for adjusting the type of therapeutic shock wave output by the shock wave generating unit 2. The focusing type of the therapeutic ultrasound wave and the therapeutic shock wave in the above-described embodiments may include one of a plane wave, a dispersion wave, a focused wave, and a semi-focused wave.
These types of waves are manifestations of the wave as it emanates and are distinguished primarily from the density of the wave. Wherein plane waves are all beams which are parallel and are not focused nor diverged; the scattered wave is that the wave beam is divergent, and the wave density is smaller than the plane wave; the beam of the focused wave is converged on a focus, so that the energy is more concentrated, and the wave density is higher; a semi-focused wave is a wave between a focused wave and a plane wave in terms of wave density, and relatively speaking, the wave density is also between the two, and is larger than the plane wave and smaller than the focused wave. The first adjusting lens and the second adjusting lens can adopt acoustic lenses to change the focusing degree of ultrasonic waves or shock waves, and change the energy concentration degree by changing different focusing types so as to obtain different treatment effects.
Referring to fig. 4, the detection unit 6 may be further included in some embodiments of the oligospermia treatment device. The detecting unit 6 is arranged at the end part of the treatment probe 3, is in signal connection with the control unit 5, and can detect the tissue state parameters of the treatment part of the asthenozoospermia and transmit the parameters to the control unit 5. The control unit 5 is capable of controlling the ultrasonic wave generation unit 1 and/or the shock wave generation unit 2 based on the result detected by the detection unit 6. Due to the difference of each individual to be treated, the tissue state parameter (such as tissue density, etc.) of the treatment site of the patient is detected by the detection unit 6, and the relevant parameters of the ultrasonic wave generation unit 1 and/or the shock wave generation unit 2 are controlled according to the tissue state parameter, so that the ultrasonic wave generation unit 1 and/or the shock wave generation unit 2 can achieve more targeted and more effective treatment effects. The control unit 5 and the detection unit 6 described above are also applicable to the third embodiment and the third embodiment, and will not be described again here.
The control unit 5 may also use a look-up table method in addition to the detection result of the detection unit 6. Referring to fig. 5, a schematic structural diagram of a fifth embodiment of the oligospermia treating apparatus according to the present invention is shown. In comparison with the previous embodiment, the present embodiment may be provided with the control unit 5 by adding the parameter storage unit 7 or replacing the detection unit 6 with the parameter storage unit 7 to provide the tissue state parameter of the treatment site. The parameter storage unit 7 is in signal connection with the control unit 5 and is used for storing a plurality of tissue state parameters corresponding to the asthenozoospermia treatment positions. The control unit 5 can query the parameter storage unit 7 according to the selection instruction of the asthenozoospermia treatment part, and control the ultrasonic wave generation unit 1 and/or the shock wave generation unit 2 according to the query result. After the therapeutic probe is set at the desired treatment site, the therapist or patient issues a selection instruction for selecting the site, and the control unit 5 can inquire about the corresponding tissue state parameter based on the selection instruction.
In the above embodiments, the parameter adjustment of the ultrasonic wave generating unit 1 and the shock wave generating unit 2 may be automatically adjusted by the control unit according to the tissue state parameter of the treatment site, or may be manually adjusted by the therapist or the patient according to the actual needs. Accordingly, a fixed or movable control panel in signal connection with the control unit 5 may also be included in some embodiments. The control panel can receive an externally input adjustment command (for example, an adjustment command sent by a person by pressing a button or a key, or operating a handle or a knob, etc.) and transmit the adjustment command to the control unit 5, and the control unit 5 can control the ultrasonic wave generating unit 1 and/or the shock wave generating unit 2 according to the adjustment command received by the control panel.
To facilitate positional adjustment of the treatment probe, a probe adjustment mechanism may also be included in some embodiments. The probe adjusting mechanism is operatively coupled with the treatment probe, and is capable of adjusting the movement position and the emission angle of the treatment probe so that the treatment probe can be more accurately and conveniently aligned with the treatment site, thereby obtaining better treatment effect.
Fig. 6 is a schematic structural view of a sixth embodiment of the oligospermia treatment device according to the present invention. In comparison with the previous embodiments, the probe adjusting mechanism of the present embodiment includes a mechanical arm 8, and the treatment probe 3 is mounted at an end of the mechanical arm 8. The weak-sperm disease treatment equipment further comprises a control unit 5, wherein the control unit 5 is respectively connected with the mechanical arm 8 and the treatment probe 3 in a signal manner, and can control the mechanical arm 8 according to the weak-sperm disease treatment part to drive the treatment probe 3 to move to the corresponding position of the weak-sperm disease treatment part, and the angle of the treatment probe 3 is adjusted. For example, when a therapist performs treatment of asthenozoospermia on a male infertility patient, the control unit 5 may be operated to move the mechanical arm 8 and aim the treatment probe 3 at the scrotum of the patient and adjust the probe angle so that the emitting end of the probe is aimed at the testis, and then adjust parameters of the therapeutic shock wave, therapeutic ultrasonic wave or ultrasonic shock wave according to the actual needs of the patient and perform the treatment.
Finally, it should be noted that the above-mentioned embodiments are only for illustrating the technical scheme of the present invention and are not limiting; while the invention has been described in detail with reference to the preferred embodiments, those skilled in the art will appreciate that: modifications may be made to the specific embodiments of the present invention or equivalents may be substituted for part of the technical features thereof; without departing from the spirit of the invention, it is intended to cover the scope of the invention as claimed.

Claims (12)

1. A device for treating asthenozoospermia, comprising: an ultrasound generating unit (1), a shock wave generating unit (2) and a treatment probe (3, 3 '), the treatment probe (3, 3') being a single treatment probe, the ultrasound generating unit (1) and the shock wave generating unit (2) being both operatively coupled to the treatment probe (3, 3 '), a treatment ultrasound, a treatment shock wave or a combination of a treatment ultrasound and a treatment shock wave being able to be selectively emitted by the treatment probe (3, 3') to a treatment site for asthenozoospermia; wherein the ultrasonic wave generating unit (1) adoptsThe ultrasonic frequency range of the used low-intensity pulse ultrasonic wave is 1-2 MHz, and the sound intensity range is 0.05-3W/cm 2 The method comprises the steps of carrying out a first treatment on the surface of the The shock wave frequency range adopted by the shock wave generating unit (2) is 1-6 Hz, and the energy range is 0.01-0.7 mJ/mm 2
2. The oligospermia treatment device according to claim 1, further comprising an ultrasonic shockwave generator (4) operatively coupled to the treatment probe (3, 3 '), the ultrasonic generating unit (1) and the shockwave generating unit (2), respectively, capable of combining therapeutic ultrasound waves and therapeutic shockwaves into ultrasonic shockwaves and emitting ultrasonic shockwaves to the oligospermia treatment site via the treatment probe (3, 3').
3. The oligospermia treatment device according to claim 1, wherein the ultrasound generating unit (1) employs an ultrasound frequency in the range of 1.5 to 1.7MHz.
4. The oligospermia treatment device of claim 1, further comprising: and a control unit (5) which is connected with the ultrasonic wave generation unit (1) and the shock wave generation unit (2) in a signal manner and can adjust parameters of the therapeutic ultrasonic wave output by the ultrasonic wave generation unit (1) and/or the therapeutic shock wave output by the shock wave generation unit (2) respectively.
5. The oligospermia treatment device of claim 4, further comprising: the detection unit (6) is arranged at the end part of the treatment probe (3, 3'), is connected with the control unit (5) in a signal manner, can detect the tissue state parameter of the treatment part of the asthenozoospermia, and transmits the tissue state parameter to the control unit (5), and the control unit (5) can control the ultrasonic wave generation unit (1) and/or the shock wave generation unit (2) according to the result detected by the detection unit (6).
6. The oligospermia treatment device of claim 4, further comprising: the parameter storage unit (7) is in signal connection with the control unit (5) and is used for storing a plurality of tissue state parameters corresponding to the treatment positions of the asthenozoospermia, and the control unit (5) can inquire the parameter storage unit (7) according to a selection instruction of the treatment positions of the asthenospermia and control the ultrasonic wave generation unit (1) and/or the shock wave generation unit (2) according to an inquiry result.
7. The oligospermia treatment device of claim 4, further comprising: the control unit (5) can control the ultrasonic wave generation unit (1) and/or the shock wave generation unit (2) according to the adjustment instruction received by the control panel.
8. The oligospermia treatment device of claim 1, further comprising: a probe adjustment mechanism operatively coupled to the treatment probe (3, 3 ') capable of adjusting the position of movement and the firing angle of the treatment probe (3, 3').
9. The device according to claim 8, wherein the probe adjusting mechanism comprises a mechanical arm (8), the treatment probe (3, 3 ') is mounted at the end of the mechanical arm (8), the device further comprises a control unit (5), the control unit (5) is respectively connected with the mechanical arm (8) and the treatment probe (3, 3') in a signal manner, and the mechanical arm (8) can be controlled according to the treatment position of the asthenozoospermia to drive the treatment probe (3, 3 ') to move to the corresponding position of the treatment position of the asthenospermia and perform the angle adjustment of the treatment probe (3, 3').
10. The oligospermia treatment apparatus according to claim 4, wherein the ultrasound generating unit (1) further comprises a first adjusting lens in signal connection with the control unit (5) for adjusting a focus type of the therapeutic ultrasound outputted by the ultrasound generating unit (1).
11. The oligospermia treatment device according to claim 4, wherein the shock wave generating unit (2) further comprises a second adjusting lens in signal connection with the control unit (5) for adjusting the type of focus of the therapeutic shock wave output by the shock wave generating unit (2).
12. The oligospermia treatment device of claim 10 or 11, wherein the type of focus comprises one of plane waves, dispersive waves, focused waves, and semi-focused waves.
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PCT/CN2019/095071 WO2020011125A1 (en) 2018-07-09 2019-07-08 Asthenozoospermia treatment device

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CN108744322B (en) * 2018-07-09 2024-03-29 北京万孛力医疗器械有限公司 Treatment equipment for asthenozoospermia
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