CN108743911A - A kind of sterilizing curing agent - Google Patents
A kind of sterilizing curing agent Download PDFInfo
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- CN108743911A CN108743911A CN201810904500.6A CN201810904500A CN108743911A CN 108743911 A CN108743911 A CN 108743911A CN 201810904500 A CN201810904500 A CN 201810904500A CN 108743911 A CN108743911 A CN 108743911A
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- sterilizing curing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The invention belongs to disinfectant preparation technical fields, disclose a kind of sterilizing curing agent, including following raw material：Poly hexamethylene biguanide, edible salt, pearl powder, collagen, blueberry extract；The present invention is sterilized by synergistic sterilizing between reasonable formula, scientific matching, combination：Synergistic directly sterilization and bacterium, fungi, virus and tumour and polypide immune, that phagocytosis is rapid, efficiently killing and phagocytosis are prevented from diffusion and permeating and dewatering; hundred times of promotion sterilization effects; multi-functional can conserve, nutrition, remove free radical, improve nerve conduction, alleviate visual fatigue, protection eyesight, reduce pigmentation and cicatrization, convergence wound, hemostasia and promoting granulation, promote wound quickly, perfect healing.
Description
Technical field
The invention belongs to disinfectant preparation technical fields, and in particular to a kind of sterilizing curing agent.
Background technology
New polymers poly hexamethylene biguanide is disinfectant, the more coloured tincture of iodine of Disinfection Effect and irritation ethyl alcohol
Difference often forms compound disinfectant with wide-spectrum bactericide Chlorhexidine.Poly hexamethylene biguanide sterilization speed is fast, effective concentration is low, nothing
Color is tasteless, nontoxic corrosion-free, is a kind of environment-friendlydisinfectant disinfectant, is defended in industry, agricultural, doctor and has use in daily life, but
Single poly hexamethylene biguanide sterilization effect is meeting after use not as good as the coloured tincture of iodine and irritation alcohol the shortcomings that the tincture of iodine
It is too strong to the irritation of wound to have the shortcomings that pigementation, alcohol.
Disinfection refers to the method for killing pathogenic microorganism, usually has the function that disinfection with the method for chemistry, for disappearing
The chemicals of poison are called disinfectant；Pathogenic microorganism is a kind of microorganism with cell membrane, and disinfectant is micro- into cause of disease
Just it can effectively be killed after in organism, conventional disinfectant enter less efficient in pathogenic microorganism body, thus kill
Bacterium Disinfection Effect is lowered；Pathogenic microorganism has certain diffusivity simultaneously in human body or in wound, in routine disinfection mistake
Cheng Zhong, pathogenic microorganism can be diffused around, and then disinfection is caused to be not thorough, and the efficiency of disinfection reduces.
The sterilization effect of single poly hexamethylene biguanide is because its chemical composition disappears not as good as the tincture of iodine and alcohol
Malicious bactericidal effect be less than the tincture of iodine and alcohol, if but certain concurrent disinfection condition can be provided for poly hexamethylene biguanide, than
The motility into efficiency and reduction pathogenic microorganism in pathogenic microorganism body is such as improved, then it is sub- can to greatly improve poly- six
The Disinfection Effect of methyl biguanides reaches degree of disinfection identical with the tincture of iodine and alcohol, and without irritation, tincture of iodine pigementation
Equal side effects；In terms of wound disinfection, for existing thimerosal, the problem is that usually healing time is longer for wound,
And often scar after healing, but there are no the poly hexamethylene biguanides for reaching said effect to disappear currently on the market
Venom has wasted the non-stimulated of poly hexamethylene biguanide, non-pigment precipitation, advantage without side-effects；It is existing simultaneously to disappear
There is also various problems for toxic agent, for example how coloured the common disinfectant of existing medical field is or there are irritation, medical treatment necks
Domain lacks efficient, non-stimulated, non-pigmented environment-friendly sterilization agent；Existing medical field often uses physiological saline, disinfection
Agent or antibiotic solution handle wound, lack multi-functional wound curing agent：Disinfection, hemostasis, myogenic, anti-oxidant reduction are freely
Pigmentation and residual scar are eliminated in base loss, promote wound quickly, perfect healing；Doctor defends, family field lacks multipurpose and uses
Sterilizing care products.
Invention content
The present invention provides a kind of sterilizing curing agent, the disinfection for solving poly hexamethylene biguanide thimerosal in the prior art
Effect is low, the technical issues of cannot reaching the Disinfection Effect of the tincture of iodine and alcohol；Meanwhile the present invention can also solve wound and be easy to stay
Scar has pigmentation, difficult cleaning of problem.
The technical solution adopted in the present invention is：
A kind of sterilizing curing agent, the Disinfection Effect for the existing poly hexamethylene biguanide thimerosal of solution is low, cannot reach iodine
The problem of wine and alcohol disinfecting effect, by weight, including 1-90 parts of poly hexamethylene biguanide, 5-90 parts of edible salt, pearl
1-90 parts of powder.
After 3 kinds of ingredient prescriptions, the efficiency of disinfection and human immunity Phagocytosis can be increased substantially, reduces and hinders
Only the microorganisms such as bacterium are adsorbed, move, increase bacterium, microbial cell film permeability, synergy sterilization effect, synergy
There is effect to the microorganisms such as bacterium, virus, polypide and tumour cell afterwards.Specific synergistic function is as follows：
1, poly hexamethylene biguanide disinfection principle：
It is in strong electropositive that poly hexamethylene biguanide generates ionization in aqueous solution, and absorption is usually in electronegative all kinds of
Bacterium, virus inhibit the synthesis of film lactones plastid, cause thalline apoptosis into cell membrane, reach the lasting bactericidal effect of strength,
It is worth noting that, poly hexamethylene biguanide is synonym with polyhexamethylene guanide, belong to same substance.
2, brine：(direct bactericidal effect+reduction adsorbs efficient bacteria removal+dehydration reduction microorganism and moves power synergistic and exempt from
Epidemic disease phagocytosis+dehydration reduces microorganism movement increase disinfection and immunization time+salt is fluorine-containing, and fluorine anti-inflammation and sterilization prevents from eating into
Worm)
Brine enables bacterium, polypide be dehydrated by osmotic pressure, direct anti-inflammation and sterilization (effect is weaker)；
Brine makes microbe infiltration be dehydrated, and dehydrated microorganism adsorption capacity reduces convenient cleaned removing；
Brine makes microbe infiltration be dehydrated, and dehydrated microorganism locomotivity reduces, and moves slowly immune phagocyte
Phagocytosis efficiency significant increase；
Brine makes microbe infiltration be dehydrated, and dehydrated microorganism locomotivity reduces, and microbial to stopping for a long time
In disinfectant, brine, immune phagocyte accumulation regions, disinfection and the immune phagocytosis equal significant increase of effect.
3, pearl powder (directly promotes the taurine be immunized+contained and promotes immune+strong adsorption enhancing disinfection and immune phagocytosis
Effect)
The taurine that pearl powder contains can improve cellular immunity, phagocytic function, promote immunoglobulin production；
Pearl powder strong adsorption force can dispel dirt, the absurd creature of dead skin and pore deep layer；Promote the cleaning micro- life of bacteria removal
Object efficiency, the suction-operated of pearl powder rest on microorganism, tumour in the compound disinfectant for a long time, disinfection and immune
Phagocytosis effect is maximized promotion；
Pearl powder, which has, improves human immunity, freckle removing and whitening, and cleaning is rotted, ulcer restrains myogenic, edema of the dorsum of the foot pain removing toxicity for detumescence
Effect.
Except Synergistic biocidal, additionally it is possible to conserve traumatic wounds, the principle of specific collaboration maintenance wound is as follows：
(1) brine makes microbe infiltration be dehydrated, and dehydrated microorganism adsorption capacity, which reduces, is easy cleaned remove；
(2) pearl powder strong adsorption force, strong adsorption microorganism promote cleaning bacteria removal microorganism efficiency, dispel simultaneously
Dead skin and the dirt of pore deep layer, absurd creature；
(3) collagen adhesion strength is strong, adhesion of microorganisms, tumour cell, promotes cleaning efficiency；
(4) poly hexamethylene biguanide disinfection, after adhesion of microorganisms is killed by poly hexamethylene biguanide, wound cleaning is clear
Wash improved efficiency.
Further, further include at least one of collagen, blueberry extract or combinations thereof, the collagen 1-
90 parts, 1-90 parts of blueberry extract.
After increasing by two kinds of ingredient prescriptions of collagen and blueberry extract, disinfection and human immunity phagocytosis can be improved
The efficiency of sterilization, reduces and prevents adsorbing, moving for the microorganisms such as bacterium, increase bacterium, microbial cell film permeability, increase
Sterilization effect is imitated, and the free radical of site of injury can be removed, makes tissue from radical damage, avoids scar.
Specific synergistic function is as follows：
1, collagen：(direct synergy is immune and cytophagy+increase residence time in composite disinfectant increases
It imitates disinfection and immune phagocytosis+prevention diffusion increases cleaning elimination efficiency and disinfection and immune phagocytosis)
Collagen collaboration promotes immunity and immunocyte phagocytic power；
Collagen is combined with immune protein, the immunity functions such as macrophage, lymph corpuscle, plasma cell, immunoglobulin
Hundred times promote enhancing confrontation foreign matter and phagocytosis bacterium, virus, the ability of cancer cell；
Collagen adhesion strength is strong, one side adhesion of microorganisms, tumour cell, promotes the phagocytosis effect that phagocyte is immunized
Rate；On the other hand the viscosity and density for increasing compound bactericide increase microorganism, tumour cell stops in composite disinfectant
Time, promote disinfection and immune phagocytosis effect；
Collagen is combined closely with wound makes the closer reduction passability of cell contact prevent microorganism, tumour cell logical
It crosses, increases elimination efficiency；Microorganism, tumour cell diffusion is prevented to promote disinfection and immune phagocytosis effect.
2, blueberry extract
(1) ingredient and purposes of blueberry extract
Blueberry contains there are many in antioxidant and interior free yl, enhances immune system.
A variety of antioxidants：Superoxide dismutase (SOD), anthocyanidin, a variety of polyphenols, pterostilbene etc.)；
Blueberry pectin being capable of effectively microorganisms and the harmful substance such as bacteria removal；
Phenolic acid in blueberry has more than ten to plant, and it is chlorogenic acid that wherein content is highest, and also known as caffeotannic acid, research finds that its is right
Kinds cancer (lung cancer, cancer of the esophagus etc.) has apparent inhibiting effect, while antioxidation is also very powerful；
Blueberry contains pterostilbene, and pterostilbene equally has good anti-oxidant, anticancer, anti-inflammatory and anti-diabetic and other effects.
Pterostilbene is also paid high attention to by people in the effect of anticancer aspect, and especially in terms of inhibitor against colon carcinoma cells, pterostilbene shows
Very gratifying effect；
Blueberry anthocyanin has anti-inflammatory efficacy, thus can prevent the inflammation including arthritis and swelling.
(2) synergetical principle of the blueberry extract in the curing agent that sterilizes：
Radical damage is reduced, promotion wound is quick, perfection is healed；Blueberry is containing important free radical scavenger " super oxygen
Object mutase (SOD) ", removes the free radical of site of injury, makes tissue from radical damage；Blueberry contains and surpasses 15 kinds of efficient anthocyanidin
And the polyphenols (e.g., chlorogenic acid) of antioxidation, wound tissue can be made from radical damage, wound is promoted quickly to be cured
It closes, avoid pigmentation；Anthocyanidin is referred to as oral cosmetics for skin, antibacterial elastoser and Collagenase, makes skin
Skin becomes smooth and high resilience；Blueberry supplements the nutrients and anthocyanidin, eliminates harmful free radical in vivo, prevents wrinkle of skin from giving birth to
Production；Blueberry nutrient is abundant, and pearl powder hydrolyzes 18 kinds of amino acid, wherein 7 kinds are essential amino acids, 20 various trace elements and
The pearl taurine of vitamin B preciousness can also promote the protein of nerve cell to synthesize, and improve nerve conduction and vision machine is resistant to
Oxidation protection retina；Blueberry anthocyanin belongs to pure natural anti-aging and nutritive replenishers, is the most effective of current mankind's discovery
Antioxidation biology activating agent, it as a kind of effective free radical can with scavenger enhance eyesight, anti-eye strain.
Significantly, since prescription sterilization is strong, hemostasis, promote quickly healing, not chromogenesis it is calm and
It remains scar and promotees perfect healing, beauty, water conservation, freckle removing and whitening, colorless and odorless, non-stimulated, nontoxic corrosion-free, environmentally friendly peace
Entirely, it can be applied in multiple fields：Due to hundred times of enhancings of disinfection, it is double that sterilization effect is much better than polyhexamethylene
Guanidine, medical field can be used for the disinfection of disinfection, especially children and mucous membrane, wound；It may be used as in the fields Wei
Beauty, disinfecting, toothbrush sanitizing cleaning, contact lens disinfection, cleaning and palm, skin, eye, the antibacterial shield of mouth and nose chamber
Reason, can also use in family, sterilized for kitchen and bath's surface sterilization sterilizing, furniture home textile sterilization and cleaning meat fruits and vegetables,
It is fresh-keeping.
Poly hexamethylene biguanide, salt, pearl powder, collagen and blueberry extract are combined as a whole by the present invention for the first time,
First passage prevents microorganism and tumour cell diffusion, makes microbe infiltration dehydration, absorption, adhesion microorganism and tumour cell,
Synergy is directly sterilized and immune, phagocytosis maximizes synergistic sterilization；Realize that multifunctional disinfecting conserves wound
It is defended with doctor, domestic multipurpose uses.
The specific effect of synergy disinfection has：Pearl powder adsorbs microorganism and tumour cell；The micro- life of collagen adhesion
Object and tumour cell；Brine makes microorganism be dehydrated；Collagen is combined closely with wound makes the closer reduction of cell contact pass through
Property prevent diffusion；The synergistic direct bactericidal effect of poly hexamethylene biguanide, brine, poly hexamethylene biguanide produce in aqueous solution
Raw ionization is in strong electropositive, and absorption is usually in that electronegative all kinds of bacteriums, virus inhibit film inner lipid into cell membrane
Body synthesizes, and causes thalline apoptosis, reaches the lasting bactericidal effect of strength；Brine enables bacterium, polypide dehydration, anti-inflammatory by osmotic pressure
It sterilizes, the fluorine contained in salt can also play anti-inflammation and sterilization, prevent from decaying tooth.Taurine that pearl powder, pearl powder contain, collagen egg
White collaboration promotes immunity and immunocyte phagocytic power, modern research shows that pearl powder is improving human immunity etc. with only
Special effect, the taurine that pearl powder contains can improve cellular immunity, phagocytic function, promote immunoglobulin production, collagen egg
It is combined in vain with immune protein, hundred times of the immunity functions such as macrophage, lymph corpuscle, plasma cell, immunoglobulin promote enhancing pair
Anti- foreign matter and phagocytosis bacterium, virus, the ability of cancer cell.
The specific effect of multi-functional maintenance wound has：By preventing microorganism and tumour cell diffusion, making microbe infiltration
Dehydration, absorption, adhesion microorganism and tumour cell and synergy are directly sterilized and immune, phagocytosis maximizes synergistic disinfection
Bactericidal effect；Pearl powder strong adsorption force, collagen adhesion strength be strong, brine strong cleaning force synergy high-efficiency cleaning, removes micro-
Biology, dirt, the absurd creature for dispelling dead skin and deep layer；Pearl powder improve human immunity, anti-aging, freckle removing and whitening, removing toxicity for detumescence,
Promote to rot and ulcer wound restrains myogenic；Collagen promotes platelet aggregation and blood plasma caking double action hemostasis；Collagen
Glycine that albumen, pearl powder, pearl powder contain promote wound quickly, perfect healing；Collagen participates in and promotes wound healing
It closes；Glycine beauty that pearl powder contains promotes skin collagen cytothesis；Pearl powder restrains myogenic, and removing toxicity for detumescence promotees perfect
It quickly heals, chromogenesis calmness and residual scar, skin do not restore original smooth at healing；Collagen, pearl powder contain
Some protective effect of taurine surface of a wound reduce damage, and collagen is combined closely with wound keeps cell contact closer, and pearl powder contains
Taurine Against oxidation make tissue from radical damage.Poly hexamethylene biguanide, salt, pearl powder, the disinfection of collagen prescription
It sterilizes, hemostasis, quickly healing, chromogenesis calmness and the perfect healing of residual scar rush, beauty, water conservation, nti-freckle are beautiful for rush
In vain, colorless and odorless, non-stimulated, nontoxic corrosion-free, Environmental Safety.
Facilitate doctor defend and domestic multipurpose use：For disinfection, the maintenance of multi-functional wound, children's disinfection nursing, clearly
Clean beauty, disinfecting, kitchen and bath's surface sterilization sterilizing, toothbrush sanitizing cleaning, contact lens disinfection cleaning and palm, skin, eye,
The antibacterial nursing of mouth and nose chamber and cleaning meat fruits and vegetables sterilize, are fresh-keeping.
Further, the sterilizing curing agent by weight, including 5-15 parts of poly hexamethylene biguanide, edible salt 5-15
Part, 45-55 parts of pearl powder, 25-35 parts of collagen.
Further, the sterilizing curing agent by weight, including 5-10 parts of poly hexamethylene biguanide, edible salt 65-
75 parts, 5-15 parts of pearl powder, 10-20 parts of blueberry extract.
Further, the sterilizing curing agent by weight, including 25-35 parts of poly hexamethylene biguanide, edible salt 5-
15 parts, 45-55 parts of pearl powder, 5-15 parts of collagen, 5-15 parts of blueberry extract.
Further, the raw material form of poly hexamethylene biguanide is polyguanidine family macromolecule polymer, poly hexamethylene biguanide
Any one or more combination in hydrochloride, phosphate.
Further, the raw material form of edible salt is sodium chloride, salt, strengthens salt, is saline solution, medical brine, medical
Any one or more combination in sugar-salt-water and other brine.
Further, sterilizing curing agent further include used as synergist or nutrition fortifier and nature and flavor conditioning agent it is auxiliary
Material, the auxiliary material be Chlorhexidine, borax, chitosan, nano silver, propolis, snow chrysanthemum, Radix Salviae Miltiorrhizae, honeysuckle, chrysanthemum, blueberry, ginger, garlic,
Any one or more combination in Chinese prickly ash, vitamin C, taurine, glycine, honey, milk, peppermint, borneol.
Further, sterilizing curing agent further include pharmaceutical adjunct, the pharmaceutical adjunct be polar solvent, nonpolar solvent,
Any one or more group in capsule shells, flavoring agent, adhesive, lubricant, coating agent.
Further, sterilize curing agent dosage form be solution, emulsion, suspension, paste, film, powder, ball
Any one in agent, tablet, capsule.
Beneficial effects of the present invention are：
(1) present invention is sterilized by synergistic sterilizing between reasonable formula, scientific matching, combination：Synergistic is direct
Sterilization and it is immune, phagocytosis is rapid, efficiently kill and phagocytosis be prevented from the bacterium of diffusion and permeating and dewatering, fungi, virus and
Tumour and polypide, hundred times of promotion sterilization effects.
(2) present invention, which has, sterilizes efficient, high-efficiency cleaning, broad-spectrum sterilization, hemostasis, detumescence, convergence myogenic, reduction free radical
Damage eliminates pigmentation and residual scar, promotes wound quickly perfect healing, and site of injury skin is promoted to restore original smooth
The advantages of.
(3) there is the present invention multi-functional care action, supplement amino acid, mineral trace element to improve nerve conduction, increase
Strong eyesight, anti-oxidant, removing free radical, eliminate asthenopia, protection retina, anti-aging and convergence wound, hemostasis, myogenic, promote
Wound quickly perfect healing.
(4) present invention safety is without side-effects, is defended in doctor and family can be used with multipurpose, can be used for medical treatment disinfection, wound
Wound nursing, children's disinfection nursing；It is clear to can be also used for beauty, disinfecting, kitchen and bath's surface sterilization sterilizing, toothbrush sanitizing
Wash, contact lens disinfection cleaning and palm, skin, eye, mouth and nose chamber it is antibacterial nursing and cleaning meat fruits and vegetables sterilization, it is fresh-keeping.
Specific implementation mode
With reference to specific embodiment, the present invention is further elaborated.
Embodiment 1：
It directly dissolved or is mixed using the ripe method of common pharmacy or industry, pelletized, tabletting, be eventually fabricated solution
Agent, emulsion, suspension, paste, film, powder, pill, tablet, capsule, component and content by weight ratio are as follows：
10 parts of poly hexamethylene biguanide, 10 parts of salt, 50 parts of pearl powder, 30 parts of collagen.
The method for taking poly hexamethylene biguanide, salt, pearl powder, collagen pharmacy or the industry of proportional quantity ripe is direct
Dissolving or mixing, granulation, tabletting, are eventually fabricated solution, emulsion, suspension, paste, film, powder, pill, tablet, capsule
Agent is for directly using.
Embodiment 2：
It directly dissolved or is mixed using the ripe method of common pharmacy or industry, pelletized, tabletting, be eventually fabricated solution
Agent, emulsion, suspension, paste, film, powder, pill, tablet, capsule, component and content by weight ratio are as follows：
5 parts of poly hexamethylene biguanide, 70 parts of salt, 10 parts of pearl powder, 15 parts of collagen.
Take the method directly dissolving or mixed that poly hexamethylene biguanide, pearl powder, salt pharmacy or the industry of proportional quantity are ripe
It closes, pelletize, tabletting, be eventually fabricated solution, emulsion, suspension, paste, film, powder, pill, tablet, capsule for direct
It uses.
Embodiment 3：
It directly dissolved or is mixed using the ripe method of common pharmacy or industry, pelletized, tabletting, be eventually fabricated solution
Agent, emulsion, suspension, paste, film, powder, pill, tablet, capsule, component and content by weight ratio are as follows：
30 parts of poly hexamethylene biguanide, 10 parts of salt, 50 parts of pearl powder, 10 parts of collagen.
The method for taking poly hexamethylene biguanide, pearl powder, salt, collagen pharmacy or the industry of proportional quantity ripe is direct
Dissolving or mixing, granulation, tabletting, are eventually fabricated solution, emulsion, suspension, paste, film, powder, pill, tablet, capsule
Agent is for directly using.
Embodiment 4：
The sterilization effect contrast test of the present invention：Sterilize curing agent (embodiment 1) product and poly hexamethylene biguanide
(1000mg/L) and iodine solution (10g/L) are used in laboratory to Candida albicans quantitative disinfecting test pair in suspension
Than this sterilizing curing agent acts on Candida albicans in suspension 2 minutes, averagely kills logarithm>4.0, polyhexamethylene is double
Guanidine acts on Candida albicans in suspension 4 minutes, averagely kills logarithm>2.45, iodine solution reads white in suspension
Pearl bacterium acts on 2 minutes, averagely kills logarithm>4.1 and poly hexamethylene biguanide comparison, this sterilizing curing agent is in action time
It is more efficient to the sterilization effect of Candida albicans in the case of shorter, it thus can determine whether under the synergistic effect between prescription, kill
Bacterium effect has obtained great promotion；And as can be seen that this sterilizing curing agent has been able to reach in being compared with iodine solution
To the bactericidal effect of the tincture of iodine.
Embodiment 5：
Contrast test of the present invention to wound healing effect：Sterilizing curing agent (embodiment 1) product and physiological sodium chloride are molten
Liquid and iodine solution carry out rat back wound model check experiment, visually observe wound healing time and take skin repair group
Knit carry out om observation；
Test result：The time of the curing agent group that sterilizes healing is (11.2 ± 1.55) day, and physiological sodium chloride solution group is
(14.0 ± 1.35) day, iodine solution group are (12.0 ± 1.35) day, and healing time difference is statistically significant (P < 0.05),
In above-mentioned test result, the healing time of this sterilizing curing agent is most short, is less than the healing time of iodine solution, and physiology chlorination
The time longest of sodium solution；The skin after the wound healing situation of observation finds the corresponding wound healing of this sterilizing curing agent simultaneously
It is smooth, without calmness pigment and residual scar；There is apparent pigmentation on the corresponding wound of the tincture of iodine；Physiological sodium chloride is corresponding
Wound skin is rough, there is slight scar residual.
Embodiment 6：
Contrast test of the present invention to oral cavity maintenance effect：Select two groups all with bleeding gums and severity extent it is close
Patient, gargled respectively using sterilizing curing agent (embodiment 2) and Black people's board mouthwash, respectively gargle one daily morning and evening
It is secondary, observe and record the time of bleeding gums situation disappearance；
Test result：The feelings of halitosis from the patient of sterilizing curing agent using the present invention just eliminates morning at third day
Condition, at the 5th day the case where bleeding gums be improved significantly, after adhering to a week, bleeding gums situation substantially eliminates；
Using the patient of Black people's board mouthwash, the case where halitosis from morning was eliminated at the 7th day, the bleeding gums after fortnight
Situation is just improved；In the case where the state of an illness is essentially identical, this sterilizing curing agent asks the oral cavity of bleeding gums and halitosis
Topic processing is more efficient, with obvious effects.
Embodiment 7：
Sterilizing curing agent (embodiment 3) product can be used as sterilizing maintenance salt, and cleaning meat, dish, cured when curing salted meat, bubble dish
Meat is more easy to maintain, meat and hardness are obviously improved, and pickles summer few raw flower helps to reduce bad retailer's formalin
Fresh-keeping meat vegetable；It can be also used for disinfecting, home textile furniture sterilization cleaning, kitchen and bath's surface sterilization sterilizing, beauty, stealthy eye
Mirror disinfection cleaning and palm, skin, eye, the daily antibacterial nursing of mouth and nose chamber, significant effect is easy to use, at low cost, facilitates medical treatment
And life.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is every to fall into the claims in the present invention confining spectrum
Technical solution, be within the scope of the present invention.
Claims (10)
1. a kind of sterilizing curing agent, it is characterised in that：By weight, including 1-90 parts of poly hexamethylene biguanide, edible salt 5-
90 parts, 1-90 parts of pearl powder.
2. a kind of sterilizing curing agent according to claim 1, it is characterised in that：Further include collagen, blueberry extract
At least one of or combinations thereof, described collagen 1-90 parts, 1-90 parts of blueberry extract.
3. a kind of sterilizing curing agent according to claim 2, it is characterised in that：The sterilizing curing agent by weight,
Including 5-15 parts of poly hexamethylene biguanide, 5-15 parts of edible salt, 45-55 parts of pearl powder, 25-35 parts of collagen.
4. a kind of sterilizing curing agent according to claim 2, it is characterised in that：The sterilizing curing agent by weight,
Including 5-10 parts of poly hexamethylene biguanide, 65-75 parts of edible salt, 5-15 parts of pearl powder, 10-20 parts of blueberry extract.
5. a kind of sterilizing curing agent according to claim 2, it is characterised in that：The sterilizing curing agent by weight,
Including 25-35 parts of poly hexamethylene biguanide, 5-15 parts of edible salt, 45-55 parts of pearl powder, 5-15 parts of collagen, blueberry extraction
5-15 parts of object.
6. according to a kind of sterilizing curing agent of claim 1-5 any one of them, it is characterised in that：The poly hexamethylene biguanide
Raw material form be polyguanidine family macromolecule polymer, hexamethylene, any one or more in phosphate
Combination.
7. a kind of sterilizing curing agent according to claim 6, it is characterised in that：The raw material form of the edible salt is chlorination
Any one or more combination in sodium, salt, reinforcing salt, saline solution, medical brine, medical sugar-salt-water and other brine.
8. a kind of sterilizing curing agent according to claim 7, it is characterised in that：The sterilizing curing agent further includes being used as increasing
The auxiliary material that effect agent or nutrition fortifier and nature and flavor conditioning agent use, the auxiliary material are Chlorhexidine, borax, chitosan, nano silver, bee
It is glue, snow chrysanthemum, Radix Salviae Miltiorrhizae, honeysuckle, chrysanthemum, blueberry, ginger, garlic, Chinese prickly ash, vitamin C, taurine, glycine, honey, milk, thin
Any one or more combination in lotus, borneol.
9. a kind of sterilizing curing agent according to claim 8, it is characterised in that：The sterilizing curing agent further includes that preparation is auxiliary
Material, the pharmaceutical adjunct are appointing in polar solvent, nonpolar solvent, capsule shells, flavoring agent, adhesive, lubricant, coating agent
It anticipates one or more combinations.
10. a kind of sterilizing curing agent according to claim 9, it is characterised in that：The dosage form of the sterilizing curing agent
For any one in solution, emulsion, suspension, paste, film, powder, pill, tablet, capsule.
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| CN201810904500.6A CN108743911A (en) | 2018-08-09 | 2018-08-09 | A kind of sterilizing curing agent |
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| CN201810904500.6A CN108743911A (en) | 2018-08-09 | 2018-08-09 | A kind of sterilizing curing agent |
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| CN111203048A (en) * | 2020-03-06 | 2020-05-29 | 西安普草瑞珊生物科技有限责任公司 | Preparation and application of non-woven fabric loaded with nano traditional Chinese medicine self-sterilization purification biological membrane |
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