CN108663390B - Simvastatin purity detector based on intelligent voice control - Google Patents
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Abstract
The invention discloses a simvastatin purity detector based on intelligent voice control, which comprises a detection module and a voice control module, wherein the voice control module comprises a voice input module, a voice recognition module and a controller, the detection module comprises a shell, an upper cover is arranged at the upper end of the shell, a crushing module is arranged at the lower part of the upper cover, a vibrating screen is arranged at the lower end of the crushing module, a container is arranged at the lower end of the vibrating screen, the upper end of the container is connected with a solvent bin through a pipeline, a discharge port is arranged at the inner bottom of the container, a temperature detection and control module is arranged on the outer wall of the container, a detector is arranged at the right side of the container, the detector is connected with a data processing chip through a wire, the data processing chip is connected with a display screen, and the data processing chip is also provided with, The simvastatin detection device can conveniently and effectively detect the purity of simvastatin, can perform intelligent control through voice, and has extremely high popularization.
Description
Technical Field
The invention relates to the technical field of nuclear magnetic resonance detection, and particularly relates to a simvastatin purity detector based on intelligent voice control.
Technical Field
Nuclear magnetic resonance spectroscopy, which is the study of the absorption of radio frequency radiation by atomic nuclei, is one of the most powerful tools for qualitative and, in some cases, quantitative analysis of the composition and structure of various organic and inorganic substances. The working principle is that in a strong magnetic field, energy level splitting of atomic nuclei occurs, and when external electromagnetic radiation is absorbed, transition of nuclear energy levels occurs, namely, a so-called NMR phenomenon occurs. When the frequency of the external radio frequency field is the same as the frequency of the nuclear spin precession, the energy of the radio frequency field can be effectively absorbed by the atomic nucleus to provide assistance for energy level transition. Thus, a particular nucleus absorbs energy from a radio frequency field at a particular frequency in a given applied magnetic field, thereby forming a nuclear magnetic resonance signal. The object of NMR studies is the absorption of radio frequency radiation by atomic nuclei in a strong magnetic field. Nuclear magnetic resonance spectrometers fall into two broad categories: high resolution nmr spectrometers and broad spectrum nmr spectrometers. The former can only measure liquid samples and is mainly used for organic analysis. The latter can directly measure solid samples and is used in the field of physics. According to the working mode of the spectrometer, a continuous wave nuclear magnetic resonance spectrometer (a common spectrometer) and a Fourier transform nuclear magnetic resonance spectrometer can be used.
Simvastatin was extracted from aspergillus terreus, was first developed by the merck pharmaceutical factory and began to enter medical use in 1992. The medicine is listed as a basic medicine list of the world health organization, belongs to one of essential medicines of a basic medical system, but in the prior art, the problem that the medicine purity detection is difficult always exists, a medicine with insufficient purity cannot achieve the purpose of treatment, the problems of the existing detection equipment, complex operation, inaccurate detection and the like exist always, the convenient collection of data, the automatic comparison of data and the like cannot be achieved, the manual operation is always adopted, and the problems of recording errors and the like easily occur in manual operation.
Disclosure of Invention
The simvastatin purity detector based on intelligent voice control is provided, operation is carried out through the voice control module, operation difficulty of a user is greatly reduced, detection efficiency is improved, the dissolving difficulty of an object to be detected is reduced through the crushing module and the vibrating screen, the quantity of the object to be detected is accurate through the meter, detection precision is higher, components and accurate content of the components can be detected more accurately through the detector which is a nuclear magnetic resonance spectrometer, database comparison can be carried out on detection results in real time through the controller and the data processing chip, the detection results can be displayed more visually through the display screen, and the simvastatin purity detector has high practical value.
In order to realize the functions, the invention is realized by the following modes:
a simvastatin purity detector based on intelligent voice control comprises a detection module and a voice control module, wherein the voice control module comprises a voice input module, a voice recognition module and a controller, the detection module comprises a shell, an upper cover is arranged at the upper end of the shell, a crushing module is arranged at the lower part of the upper cover, a vibrating screen is arranged at the lower end of the crushing module, a meter is arranged at the lower end of the vibrating screen, a container is arranged at the lower end of the meter, the upper end of the container is connected with a solvent bin through a pipeline, a discharge port is arranged at the bottom inside the container, a liquid storage bin is arranged below the discharge port, a temperature detection and control module is arranged on the outer wall of the container, a detector is arranged at the right side of the container, the detector is connected with a data processing chip through an electric wire, and the data processing, the data processing chip is also provided with a network external port and a data transmission port.
As a preferred technical scheme, the voice recognition module is provided with a wireless connection port, and the wireless connection port is connected to the cloud platform database through a network signal.
In a preferred embodiment, a first motor is provided at one end of the upper cover, a container cover is provided at an upper portion of the container, and a second motor unit is attached to one end of the container cover.
As a preferable technical scheme, the meter is a weighing meter and is a gyroscope type sensor.
As a preferred technical solution, the detector is a nuclear magnetic resonance spectrometer.
As a preferred technical solution, the detector is a high resolution nuclear magnetic resonance spectrometer.
As a preferred technical scheme, a flow meter and a first electromagnetic valve are arranged on a pipeline connecting the solvent bin and the container, the discharge port is connected with the liquid storage bin through a pipeline, and a second electromagnetic valve is arranged on the pipeline between the discharge port and the liquid storage bin.
As a preferred technical scheme, the controller is electrically connected with the voice recognition module, the first motor, the crushing module, the vibrating screen, the meter, the second motor set, the flowmeter, the first electromagnetic valve, the second electromagnetic valve, the temperature detection and control module, the detector and the data processing chip through electric wires respectively.
As a preferred technical solution, the work flow of the controller is as follows:
(a) detecting a voice input module signal and preparing voice recognition work;
(b) the voice recognition module works, is connected with a cloud platform database through a network, and performs comparison recognition;
(c) comparing and analyzing the data to obtain a control command, and performing control work;
(d) sending a signal to the first motor to open the upper cover;
(e) putting an article to be detected;
(f) closing the upper cover, controlling the crushing module to work, and crushing the article to be detected;
(g) controlling the vibrating screen to work, and screening the crushed to-be-detected articles;
(h) the meter works, and when a preset value is reached, a signal is sent to the controller;
(i) the controller sends out a signal, and the vibrating screen and the crushing module stop working;
(j) the controller sends out a signal, the second electromagnetic valve and the first electromagnetic valve are in a closed state, the second motor set works, the container cover is opened, and the second motor set controls the container cover to be closed when the numerical value of the metering device returns to zero;
(k) the controller calculates according to the signal of the meter, opens the first electromagnetic valve, at this moment, when the flowmeter reaches the preset value, the controller controls the first electromagnetic valve to close;
(l) The controller monitors the temperature of the solvent mixed liquid in real time through the temperature detection and control module;
(m) the controller sends out a signal, the detector works, and each component and the proportion of the solution in the container are detected;
(n) the data processing chip receives the signal, is connected with the cloud database through a network external port, compares data and judges whether the data is qualified;
(o) the data processing chip sends data to the display screen, and the display screen contrasts and presents the data to a user;
(p) the controller sends out a signal, the data processing chip records data, sorts the data and enters a state to be sent for a user to receive;
(q) after the detection is finished, the controller sends a signal, the second electromagnetic valve is opened, the waste liquid is discharged to the liquid storage bin, the second electromagnetic valve is closed, the first electromagnetic valve is opened, the solvent flows in, and the container is cleaned;
(r) after the cleaning is finished, the controller sends out a signal, the first electromagnetic valve is closed, the second electromagnetic valve is opened, and the cleaning liquid is discharged to the liquid storage bin;
and(s) after the detection is finished, the controller enters a standby state and detects the signal of the voice input module at regular time.
The invention achieves the following beneficial effects: through using the speech control module to operate, the user's the operation degree of difficulty has significantly reduced, detection efficiency is improved, through using crushing module, the shale shaker has reduced the degree of difficulty of dissolving of waiting to detect the object, and through the counter, the volume of waiting to detect the object has been accurate, make the detection precision higher, through using the detector, and the detector is nuclear magnetic resonance spectrometer, the component that contains and accurate content can more accurate detection, through using the controller, the data processing chip, can be real-timely carry out the database contrast to the testing result, through the display screen, can more audio-visual demonstration testing result, and has very high practical value, and has very high market popularization nature.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Fig. 1 is an external view schematically showing the present invention.
Fig. 2 is a schematic view of the internal cross-sectional structure of the present invention.
FIG. 3 is a speech recognition module workflow diagram of the present invention.
Shown in the figure: 1. a voice input module; 2. a voice recognition module; 3. a controller; 4. a housing; 5. an upper cover; 501. a first motor; 6. a crushing module; 7. vibrating screen; 701. a meter; 8. a container; 801. a container cover; 802. a second motor group; 9. a solvent bin; 901. a flow meter; 902. a first solenoid valve; 10. an outlet port; 1001. a liquid storage bin; 1002. a second solenoid valve; 11. a temperature detection and control module; 12. a detector; 13. a data processing chip; 14. a display screen.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
As shown in the figure, the simvastatin purity detector based on intelligent voice control comprises a detection module and a voice control module, wherein the voice control module comprises a voice input module 1, a voice recognition module 2 and a controller 3, the detection module comprises a shell 4, an upper cover 5 is arranged at the upper end of the shell 4, a crushing module 6 is arranged at the lower part of the upper cover 5, a vibrating screen 7 is arranged at the lower end of the crushing module 6, a meter 701 is arranged at the lower end of the vibrating screen 7, a container 8 is arranged at the lower end of the meter 701, the upper end of the container 8 is connected with a solvent bin 9 through a pipeline, a discharge port 10 is arranged at the bottom inside the container 8, a liquid storage bin 1001 is arranged below the discharge port 10, a temperature detection and control module 11 is arranged on the outer wall of the container 8, a detector 12 is arranged on the right side of, the detector 12 is connected with a data processing chip 13 through an electric wire, the data processing chip 13 is connected with a display screen 14, and the data processing chip 13 is further provided with a network external port and a data transmission port.
In this embodiment, as an optimal technical solution, the voice recognition module 2 is provided with a wireless connection port, and the wireless connection port is connected to the cloud platform database through a network signal.
In this embodiment, as a preferable configuration, a first motor 501 is provided at one end of the upper cover 5, a container cover 801 is provided on the upper portion of the container 8, and a second motor group 802 is attached to one end of the container cover 801.
In this embodiment, as a preferable technical solution, the meter 701 is a weighing meter and is a gyroscope sensor.
In this embodiment, as a preferable technical solution, the detector 12 is a nuclear magnetic resonance spectrometer.
In this embodiment, as a preferable technical solution, the detector 12 is a high-resolution nmr spectrometer.
In this embodiment, as a preferable technical solution, a flow meter 901 and a first electromagnetic valve 902 are arranged on a pipeline connecting the solvent bin 9 and the container 8, the discharge port 10 is connected with the liquid storage bin 1001 through a pipeline, and a second electromagnetic valve 1002 is arranged on a pipeline between the discharge port 10 and the liquid storage bin 1001.
The simvastatin in this example has the structural formula:
simvastatin can be hydrolyzed from lovastatin with lithium hydroxide, lactonized to diol lactone, selectively silylated with TBDS, acylated and desilylated; 2) directly methylating lovastatin potassium salt; and (3) a method in which lovastatin monosalicylamide is directly methylated, and the like.
Specifically, lovastatin may be added to a solution of KOH in t-butanol, and the mixture stirred at room temperature under argon. Then, the temperature was raised and the mixture was refluxed with stirring. The reaction mixture was concentrated under reduced pressure, water was added, acidified with phosphoric acid (pH = 3.5), and extracted with ethyl acetate. The extract was concentrated under reduced pressure to give a brown oil. The brown oil was dissolved in isopropyl acetate, methanesulfonic acid was added, and the mixture was concentrated under reduced pressure. The residue was washed with saturated aqueous sodium bicarbonate, cooled to-20 ℃ and stirred. The resulting slurry was filtered and dried under vacuum to give white crystals.
To the obtained toluene solution of the triol acid derivative, pyridine, 4-dimethylaminopyridine and 2, 2-dimethylbutyrylchloride were added, and the mixture was stirred at 100 ℃ for 6 hours under nitrogen. After 6 hours from the start of the reaction, a part of the reaction mixture was quantified by HPLC analysis, and after 8 hours of the reaction, water was added to the reaction mixture and stirred at room temperature for 3 hours to decompose residual acid chloride into carboxylic acid. The aqueous solution is separated to remove water soluble impurities including carboxylic acid and pyridine. The organic solution was further washed with water 3 times to obtain a toluene solution of the objective compound having a residual pyridine content.
To a toluene solution of the obtained simvastatin derivative was added HCl, and the mixture was vigorously stirred under nitrogen at room temperature. After 10 hours, it was confirmed by TLC that the starting simvastatin derivative was substantially completely disappeared, and after addition of toluene, the aqueous layer was separated. The organic layer was washed with water and then with a saturated aqueous solution of sodium chloride. Then, p-toluenesulfonic acid was added, and the lactonization was started by heating and refluxing under nitrogen. After cooling, the reaction mixture is added and washed with water with stirring and the toluene is concentrated until simvastatin crystals are isolated.
The specific steps of the nuclear magnetic resonance detection of the simvastatin purity can be as follows: NMR spectra were recorded on a spectrometer and 13C and 1H observations were made, respectively, using a dual resonance probe. 13C cross polarization/magic angle rotation was obtained with a contact time of 1 or 3ms, an RF pulse duration of 4 mus (90 °), using continuous wave radiation at the nominal frequency of protons, 4 seconds of recirculation delay and 400 scans.
A standard CP pulse sequence can be used with a 1 ms contact time, a 90 ° pulse duration of 5 μ s, interruption of proton spin locking in the cross-polarization period of 2 ms to 16 ms, and a 5 s cyclic delay. The detection ring is down for 8 mus.
Five frequency regions were identified in the 13C chemical shifts of the carbon core obtained for simvastatin, which correspond to the carbons of the structural formula number of simvastatin (in parentheses): 185-165ppm (18, 1), 140-120ppm (10, 12,11, 17), 80-60ppm (5, 14, 3), 45-20ppm and 20-10 ppm (25, 21).
On the other hand, the spectrum of the amorphous sample shows a significant asymmetric line spread of the C18 and C1 resonances: ranging from about 168 to 175ppm for C1, maximum intensity of 172ppm, and ranging from about 175 to 182 ppm for C18, maximum intensity of 177 ppm.
Comparison of the nuclear magnetic resonance spectra of amorphous and crystalline simvastatin enables the following to be observed: (a) some signals, in particular different relative intensities from CH groups (59-79 ppm), and (b) the widely broadened (methyl) signals of C24 and C25.
Effect of temperature of simvastatin: the effect of temperature is particularly pronounced on the simvastatin carbon nucleus, and the signals of the aromatic (C10, 11,12, 17) and carbonyl (C1, 18) nuclei are strongly amplified by increasing the temperature.
The 1H MAS NMR spectrum of simvastatin was used for the lorentzian curve deconvolving the centerline and the subsequent fourier transform, respectively; after baseline correction, the spectra obtained were deconvoluted with the lorentz function to give the following chemical shifts and full widths: 0.950 ppm, 1.100ppm and 3.830ppm, (b) 0.850ppm and 3.840 ppm.
In this embodiment, as a preferable technical solution, the controller 3 is electrically connected to the voice recognition module 2, the first motor 501, the crushing module 6, the vibrating screen 7, the meter 701, the second motor set 802, the flow meter 901, the first electromagnetic valve 902, the second electromagnetic valve 1002, the temperature detection and control module 11, the detector 12, and the data processing chip 13 through electric wires, respectively.
In this embodiment, as a preferred technical solution, the work flow of the controller 3 is as follows:
(a) detecting a voice input module signal and preparing voice recognition work;
(b) the voice recognition module 2 works, is connected with a cloud platform database through a network, and performs comparison recognition;
(c) comparing and analyzing the data to obtain a control command, and performing control work;
(d) a signal is sent to the first motor 501 to open the upper cover 5;
(e) putting an article to be detected;
(f) closing the upper cover 5, controlling the crushing module 6 to work, and crushing the article to be detected;
(g) controlling the vibrating screen 7 to work, and screening the crushed to-be-detected articles;
(h) the meter 701 works, and when a preset value is reached, a signal is sent to the controller 3;
(i) the controller 3 sends out a signal, and the vibrating screen 7 and the crushing module 6 stop working;
(j) the controller sends out signals, the second electromagnetic valve 1002 and the first electromagnetic valve 902 are in a closed state, the second motor set 802 works, the container cover 801 is opened, and when the value of the meter 701 returns to zero, the second motor set 802 controls the container cover 801 to be closed;
(k) the controller 3 calculates according to the signal of the meter 701, and opens the first electromagnetic valve 902, and at this time, when the flow meter 901 reaches a preset value, the controller 3 controls the first electromagnetic valve 902 to close;
(l) The controller 3 monitors the temperature of the solvent mixed liquid in real time through the temperature detection and control module 11;
(m) the controller 3 sends out a signal, the detector 12 works, and each component and the proportion of the solution in the container 8 are detected;
(n) the data processing chip 13 receives the signal, is connected with a cloud database through a network external port, compares data and judges whether the data is qualified;
(o) the data processing chip 13 sends the data to the display screen 14, and the display screen 14 contrasts and presents the data to the user;
(p) the controller 3 sends out a signal, the data processing chip 13 records data, and arranges the data to enter a state to be sent for a user to receive;
(q) after the detection is finished, the controller 3 sends a signal, the second electromagnetic valve 1002 is opened, the waste liquid is discharged to the liquid storage bin 1001, the second electromagnetic valve 1002 is closed, the first electromagnetic valve 902 is opened, the solvent flows in, and the container 8 is cleaned;
(r) after the cleaning is finished, the controller 3 sends a signal, the first electromagnetic valve 902 is closed, the second electromagnetic valve 1002 is opened, and the cleaning liquid is discharged to the liquid storage bin 1001;
(s) after the detection, the controller 3 enters a standby state and detects the signal of the voice input module 1 at regular time.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (2)
1. The utility model provides a simvastatin purity detector based on intelligence speech control, includes detection module, speech control module, its characterized in that: the voice control module comprises a voice input module (1), a voice recognition module (2) and a controller (3), the detection module comprises a shell (4), an upper cover (5) is arranged at the upper end of the shell (4), a crushing module (6) is arranged at the lower part of the upper cover (5), a vibrating screen (7) is arranged at the lower end of the crushing module (6), a meter (701) is arranged at the lower end of the vibrating screen (7), a container (8) is arranged at the lower end of the meter (701), a first motor (501) is arranged at one end of the upper cover (5), a container cover (801) is arranged at the upper part of the container (8), a second motor set (802) is installed at one end of the container cover (801), the upper end of the container (8) is connected with a solvent bin (9) through a pipeline, and a discharge port (10) is arranged at the bottom inside the container, a liquid storage bin (1001) is arranged below the discharge port (10), a flow meter (901) and a first electromagnetic valve (902) are arranged on a pipeline connecting the solvent bin (9) and the container (8), the discharge port (10) is connected with the liquid storage bin (1001) through a pipeline, a second electromagnetic valve (1002) is arranged on the pipeline between the discharge port (10) and the liquid storage bin (1001), a temperature detection and control module (11) is arranged on the outer wall of the container (8), a detector (12) is arranged on the right side of the container (8), the detector (12) is a nuclear magnetic resonance spectrometer, the detector (12) is connected with a data processing chip (13) through an electric wire, the data processing chip (13) is connected with a display screen (14), and the data processing chip (13) is further provided with a network external port and a data transmission port;
the voice recognition module (2) is provided with a wireless connection port, and the wireless connection port is connected to the cloud platform database through a network signal;
the controller (3) is electrically connected with the voice recognition module (2), the first motor (501), the crushing module (6), the vibrating screen (7), the meter (701), the second motor set (802), the flowmeter (901), the first electromagnetic valve (902), the second electromagnetic valve (1002), the temperature detection and control module (11), the detector (12) and the data processing chip (13) through electric wires respectively;
the work flow of the controller (3) is as follows:
(a) detecting a voice input module signal and preparing voice recognition work;
(b) the voice recognition module (2) works, is connected with a cloud platform database through a network, and performs comparison recognition;
(c) comparing and analyzing the data to obtain a control command, and performing control work;
(d) sending a signal to the first motor (501) to open the upper cover (5);
(e) putting an article to be detected;
(f) closing the upper cover (5), controlling the crushing module (6) to work, and crushing the article to be detected;
(g) controlling the vibrating screen (7) to work, and screening the crushed objects to be detected;
(h) the meter (701) works, and when a preset value is reached, a signal is sent to the controller (3);
(i) the controller (3) sends out a signal, and the vibrating screen (7) and the crushing module (6) stop working;
(j) the controller sends out signals, the second electromagnetic valve (1002) and the first electromagnetic valve (902) are in a closed state, the second motor set (802) works, the container cover (801) is opened, and when the numerical value of the meter (701) returns to zero, the second motor set (802) controls the container cover (801) to be closed;
(k) the controller (3) calculates according to the signal of the meter (701), and opens the first electromagnetic valve (902), and at the moment, when the flowmeter (901) reaches a preset value, the controller (3) controls the first electromagnetic valve (902) to close;
(l) The controller (3) monitors the temperature of the solvent mixed liquid in real time through the temperature detection and control module (11);
(m) the controller (3) sends out a signal, the detector (12) works, and all components and the proportion of the solution in the container (8) are detected;
(n) the data processing chip (13) receives the signal, is connected with the cloud database through a network external port, compares data and judges whether the data is qualified;
(o) the data processing chip (13) sends the data to the display screen (14), and the display screen (14) contrasts and presents the data to a user;
(p) the controller (3) sends out a signal, the data processing chip (13) records data, sorts the data and enters a state to be sent for a user to receive;
(q) after the detection is finished, the controller (3) sends a signal, the second electromagnetic valve (1002) is opened, the waste liquid is discharged to the liquid storage bin (1001), the second electromagnetic valve (1002) is closed, the first electromagnetic valve (902) is opened, the solvent flows in, and the cleaning container (8) works;
(r) after the cleaning is finished, the controller (3) sends a signal, the first electromagnetic valve (902) is closed, the second electromagnetic valve (1002) is opened, and the cleaning liquid is discharged to the liquid storage bin (1001);
(s) after the detection, the controller (3) enters a standby state and detects the signal of the voice input module (1) at regular time.
2. The simvastatin purity detector based on intelligent voice control of claim 1, wherein: the meter (701) is a weighing meter and is a gyroscope type sensor.
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