CN108607139A - Thrombocyte plasma solution, which is will be enriched in, via sucking is delivered to personal system - Google Patents
Thrombocyte plasma solution, which is will be enriched in, via sucking is delivered to personal system Download PDFInfo
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- CN108607139A CN108607139A CN201611141354.3A CN201611141354A CN108607139A CN 108607139 A CN108607139 A CN 108607139A CN 201611141354 A CN201611141354 A CN 201611141354A CN 108607139 A CN108607139 A CN 108607139A
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- solution
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- sufferer
- sprayer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0605—Means for improving the adaptation of the mask to the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Present application is related to a kind of for will be enriched in the system that thrombocyte plasma solution is delivered to individual via sucking.The example of the present invention includes intake system, breathing apparatus and the method for delivering the solution to sufferer via sucking.Example breathing apparatus as described herein can be configured so as to be lost to solution-minimized in environment.Additionally or alternatively, example breathing apparatus can be configured so that the recycling solution of exhalation, to increase the amount of the solution workable for sufferer, while make the solution-minimized of discharge.In some instances, breathing apparatus can deliver the Platelet-rich plasm " PRP " of atomization.
Description
Technical field
Example of the present invention is related to intake system, including the recyclable intake system through breathing out solution.Some realities
Example includes the system for delivering the Platelet-rich plasm for sucking.
Background technology
Respiratory disease includes to influence the disease of air duct, and air duct may include nostril, bronchus and/or lung.
These diseases may include acute infection (such as pneumonia and bronchitis) and chronic disease, for example, asthma and chronic obstructive pulmonary
Disease.According to the World Health Organization (data), the number of whole world suffering from asthma is 2.35 hundred million at present.The whole world in 2005 is died of chronic
The number of obstructive lung disease (COPD) is more than 3,000,000.In addition, according to control and prevention of disease center (data), in the U.S., exhaled under chronic
Suction tract disease is the third-largest cause of death, while in the annual death toll in the U.S., having 1/5 to die of and being caused to health by smoking
Negative effect.
Currently, include to be used to open the bronchodilator of breathing access for the common treatment that respiratory disease uses
And steroids and other anti-inflammation drugs for reducing pneumonia.But these treatments are palliative.Bronchodilator and class are solid
Alcohol also has undesirable side effect.Particularly, it is known that bronchodilator can cause anxiety, muscular tremor, anxiety and the heart
Throb with fear.In addition, U.S.'s food and Drug Administration are it is reported that claim, some bronchodilators may cause breathing more difficult.
Similarly, corticosteroid can cause systemic side effect, for example, inhibiting children growth, bone mineral density reduction, thinning of skin
And dampen and cataract and infection in respiratory system, weight gain and pharyngitis.In addition, the sufferer for suffering from COPD, cortex class is solid
Alcohol can only play therein 10% crowd effect and in most cases be directed to asthma and nurse.
Commercially available inhalator there are the shortcomings that it is numerous, including the inexactness of the dosage of delivering and using propellant and
Delivered drug is caused to be lost in air.In addition, for respiratory disease, the inhalator being currently available can only be used to
Sickness nursing rather than thoroughly healing.
Invention content
In one embodiment, it provides and is delivered to personal system for will be enriched in thrombocyte plasma solution via sucking.
The system comprises：Sprayer, it includes the sterile ports for receiving Platelet-rich plasm solution；Connector tube, warp
It is coupled to the sprayer and configures molten to receive the Platelet-rich plasm into port by the connector tube
The fog of liquid；Breathing mask, through being connected to the connector tube and being configured to the fog being delivered to the individual；Again
Respiratory chamber, through being connected to the connector tube and configuring to receive the exhalation part of the fog from the individual simultaneously
Exhalation at least some of part are made to be recycled back into the individual, the re-breathing room includes；It is connected to the connector
The first end of pipe；And second end, it is opposite with the first end；Delivery pipe is connected to described in the proximal end of the delivery pipe
The second end of re-breathing room and configure with collect the fog through discharge unit；And cleaning unit, it is connected to institute
The distal end of delivery pipe is stated, the cleaning unit is configured to assist the evaporation loss in the system to be humidified whereby across it
Oxygen and clean the described through discharge unit of the fog.
Description of the drawings
Fig. 1 is illustrates that according to an embodiment of the invention sucked using breathing apparatus delivers the intake system of solution
Block diagram.
Fig. 2A is the schematic diagram according to the example of the breathing apparatus for delivering solution of the embodiment of the present invention.
Fig. 2 B are the schematic diagram according to the strainer cover of the embodiment of the present invention.
Fig. 3 is the schematic diagram according to another example of the breathing apparatus comprising head band of the embodiment of the present invention.
Fig. 4 is the schematic diagram according to another example of the breathing apparatus comprising sprayer of the embodiment of the present invention.
Fig. 5 is the schematic diagram according to another example of the breathing apparatus comprising PEEP valves of the embodiment of the present invention.
Fig. 6 is the schematic diagram according to the hand-held intake system of the embodiment of the present invention.
Fig. 7 is the flow chart according to the instance method treated using breathing apparatus of the embodiment of the present invention.
Fig. 8 is the schematic diagram according to the example of the breathing apparatus for delivering solution of the embodiment of the present invention.
Fig. 9 be according to the embodiment of the present invention with for delivering the cleaning unit that the breathing apparatus of solution is used together
Schematic diagram.
Specific implementation mode
The example of the present invention includes intake system, breathing apparatus and the side for delivering the solution to sufferer via sucking
Method.Example breathing apparatus as described herein, which can be configured so that, is lost to the solution-minimized of environment.Additionally or alternatively, real
Example breathing apparatus can be configured so that through breathing out recycling solution, to increase the amount of solution workable for sufferer, while make through exhaling
It is minimum to go out solution.In some instances, breathing apparatus can deliver atomization Platelet-rich plasm (PRP), it is also possible, however, to use this
Equipment and system described in text deliver other solution.In some instances, sufferer may suffer from respiratory disorder, can be via passing
It send atomization Platelet-rich plasm to treat the illness, is needed using herein however, sufferer has no other any very pathologies
The system or equipment.
Platelet-rich plasm (PRP) or Platelet-rich plasm/stem cell compositions refer generally to be enriched with blood platelet
Blood plasma.Therefore, PRP may include a variety of growth factors and can stimulate other cell factors of bone and organization healing.Usually, may be used
Via whole blood is mixed with anti-coagulants and is made Platelet-rich plasm and red blood cell and platelet poor plasma with centrifugation
It detaches and obtains Platelet-rich plasm from whole blood.
Active Platelet-rich plasm can increase the growth factor in human tissue, be re-formed with vasostimulant, and change
Good alveolar membrane entire surface, this can promote, and oxygen extracts and the gas exchanges of carbon dioxide are (for example, reducing lung's dead space, mitigating
The cardiopulmonary live load of body, to maintain acid-base balance).Studies have shown that Platelet-rich plasm increases vascular endothelial growth
It the factor (VEGF) and platelet derived growth factor (PDSF-BB), transforming growth factor beta (TSF- β) and has shown to push away
The release of slow interleukin 1-beta (IL-1- β).For example, with reference to Y.Roussey et al. it is written " mankind be rich in blood platelet
The activation of blood plasma：To growth factor release, cell division and the influence of live body bon e formation " (Activation of human
platelet-rich plasma:effect on growth factors release,cell division and in
Vivo bone formation) (in October, 2007 is published in<Clinical mouth implantation material is studied>Volume 18 page 639 of the fifth phase
To page 648), the full text of the article is incorporated herein by reference for any purpose.
In order to make reader fully understand the example of the present invention, specific details is set forth below.However, the technology of fields
Personnel will be understood that, the example of the present invention can be put into practice in the case of not having these specific details.In some cases, in order to avoid
Unnecessarily obscure described the embodiment of the present invention, be not painted well-known sample preparation agreement, medical apparatus component and
Therapy.
Fig. 1 is illustrates that according to an embodiment of the invention sucked using breathing apparatus delivers the intake system of solution
Block diagram.Intake system 100 shown in Fig. 1 is for delivering PRP to be sucked.However, as described above, in other examples,
The example of system and equipment as described herein can also be used to deliver other solution.The solution packet of the example delivering of the present invention can be used
Contain but be not limited to, Platelet-rich plasm solution, it includes Platelet-rich plasm/stem cell solution (for example, liquid), anaemias
Platelet-poor plasma solution, whole blood and synthesis and organic medicine and/or chemotherapy mixture or compound solution.In general, originally
The embodiment of breathing apparatus described in text may be especially useful for either for health reasons or due to the solution cost not
Wish that it is lost to the solution of environment (for example, Platelet-rich plasm solution).However, the embodiment of the present invention is not limited to this
A little solution, and can be generally used for wishing being delivered to any solution of sufferer via sucking.
Referring again to FIGS. 1, carrying out treatment to sufferer starts from the identification disease at frame 101.Identification disease not necessarily uses
The example of the present invention, includes the system 100 of Fig. 1, however, disease is identified to show that the system 100 using Fig. 1 is excellent
Choosing.The instance system 100 of Fig. 1 illustrates that the system for delivering PRP, the system can be used for treating respiratory disease
And/or it can be in the case of even if there be no disease simply for improvement lung function.At frame 102, it can be taken out from the sufferer
Take peripheral veins blood.In other examples, alternatively or additionally using venous blood or arterial blood.In frame 103, make through receiving
The peripheral veins blood of collection centrifuges, to collect PRP in frame 104.Therefore, in some instances, obtained from the blood of sufferer itself
PRP can be delivered to sufferer and the sufferer is allowed to suck.In other examples, frame 102 to frame 104 may not occur, and can
Another sources PRP provided are provided, can from or can not be obtained from the sufferer blood of itself sources PRP (for example, can will
PRP from the matched people of another blood group (such as from donor or blood bank) is delivered to sufferer).For example, can at frame 105
Platelet-rich plasm is set to be atomized via the Platelet-rich plasm is provided to sprayer.The atomization of PRP allows
Sufferer 110 uses breathing apparatus 111 to be sucked PRP as fog at frame 106, and the breathing apparatus 111 may make the sufferer
Lung start inflammatory reaction.It, can through exhalation and the PRP without using at frame 107 when the sufferer 110 sucks in PRP
It is recycled back into the sufferer 110.In block 108, any other PRP without using and breathing out can be filtered, and later
It discharges into the atmosphere as cleaning emission at frame 109.
In some instances, it breathing apparatus 111 can be used to execute frame 106 and arrive frame 109, described exhale is further described below
Inhale the example of equipment 111.Also frame 101 can be executed via the component except breathing apparatus and arrives frame 105, but in some instances, it can
Some functions of the frame 101 to frame 105 are integrated in the breathing apparatus 111.For example, as described further below,
Sprayer can be attached to the breathing apparatus 111 or keep the sprayer integral with the breathing apparatus 111, to execute
Frame 105.In some instances, can additionally or alternatively by a centrifuge be attached to the breathing apparatus 111 or with it is described
Breathing apparatus 111 is integral, to execute PRP collections, as shown in block 104.
Fig. 2A is the schematic diagram according to the example of the breathing apparatus for delivering solution of the embodiment of the present invention.Breathing is set
Standby 200 include breathing mask 201, may be connected to connector tube 202.The connector tube 202 is incorporated into port 203,
For delivering the fog (for example, atomized soln) to be delivered to sufferer.Far from the end for being attached with the breathing mask 201
The end of the connector tube 202 could attach to re-breathing room 204.The re-breathing room 204 can be via making without using and breathing out
Atomized soln be circulated back to the sufferer and prevent or reduce the loss of the solution.For example, the connector tube 202 can be with
' T ' shape connector is formed into the fog source (for example, atomized soln) for entering port 203.' T ' the shape connector can be connected to simultaneously
The mask 201 and the re-breathing room 204.When sufferer air-breathing, the sufferer it is acceptable from described into port 203
Fog, and the solution that is contained in the re-breathing room 204.When the sufferer is exhaled, the solution through exhalation can be contained in institute
State in re-breathing room 204 and can by the sufferer with after sucking when use.During expiration, it can continue to lead to through atomized soln
It crosses the entrance port 203 and delivers, and can also be contained in the re-breathing room 204 and/or the connector tube 202.
During next sucking, (no matter in sucking and/or expiration phase) is delivered by the entrance port 203 and is stored in described device
In fresh atomized soln can be sucked by the sufferer together with the previous solution through exhalation being contained in the re-breathing room.With
This mode, relative to through breathing out the solution system that can not be recycled back into the sufferer, the re-breathing room 204 can reduce without
Use the amount of solution.
The re-breathing room 204 can by suitable for accommodate the generally any material through exhalation air and solution be made, and
It can be flexible in some examples, and may expand and shrink during expiration and sucking respectively in some instances.It is described to exhale again
Suction-chamber 204 further can be connected to delivery pipe 205 via opening 207, and the delivery pipe 205 can be wavy delivery pipe.The row
Putting pipe 205 can carry through exhalation air and without using solution (for example, PRP solution), can also pass through the re-breathing room 204
And it is recycled to outlet, to be discharged.The delivery pipe 205 may include positioned at the clear of the distal end of the delivery pipe 205
Clean unit 206.Cleanable (the sterilizing in some instances) emission (for example, it may include PRP) of cleaning unit, and
The emission is discharged into the atmosphere after the cleaning.The cleaning unit may include filter, ultraviolet light source and be suitable for
Other devices that emission from the re-breathing room 204 is cleaned and/or sterilized.Additionally or alternatively, it can be directed to
Emission from the connector tube 202 provides filter 210.In some instances, the filter 210 may not deposited
, and it is solid for the region comprising the filter 210 that the connector tube, which can cross as shown,.
Fig. 2A is referred back to, as described above, the breathing mask 201 may be connected to connector tube 202.In the reality of the present invention
In example, the connector tube 202 can be T shapes, and have different attachments at each end.As shown in Figure 2 A, the connection
One end of device pipe 202 may be connected to the breathing mask 201, and other two end is connected respectively into port 203 and described
Re-breathing room 204.It is described to can be used for delivering fog (for example, PRP solution of atomization) into port 203.As shown in Figure 3 and under
Text is explained further, and can sprayer be attached to the connector tube at the entrance port 203, so as to be delivered arrive sufferer
Solution (for example, PRP solution) atomization.In the example of the present invention, the connector tube 202 can be made up of polypropylene；However,
When constructing the connector tube 202, any suitable material can be used.The connector tube 202 (can be exhaled with three attachments
Inhale mask 201, attached sprayer with selection enters port 202 and re-breathing room 203) formed it is gas-tight seal, to subtract
It less or prevents fog (for example, through atomized soln) from losing, therefore increases the sucking of fog.
The re-breathing room 204 could attach to the distal end of the connector tube 202, and can make through breathing out fog (example
Such as, the PRP solution through atomization) recycling.In instances, it can be used and made of rubber cave in bag to implement the re-breathing
Room 204.The bag can suck and breathe out the fog (for example, through being atomized PRP solution) with sufferer and expand and shrink.Example
Such as, in some examples of the present invention, the advantages of re-breathing room 204, is that fog (for example, PRP solution through atomization) can be increased
Utilization rate.In some instances, described cave in can have nonlinear organization, can be generated in the re-breathing room 204
Through breathing out fog swirling flow.It is not only restricted to theory, this swirling flow can be facilitated so that the recycling solution returns to the sufferer, to carry out
Sucking.Therefore, the sufferer can repeatedly breathe identical fog (for example, PRP solution), this, which can increase, is delivered to the sufferer
The solution (for example, PRP) of lung.By this method, it can reduce and not damaged first by the wavy pipe 205 by sufferer sucking
The amount of the solution of mistake.Therefore, the re-breathing room 204 can even be assisted with a small amount of solution (for example, the PRP obtained from sufferer)
Improve inhalation therapy.
Fig. 2A is also painted delivery pipe 205, and the distal end of the re-breathing room 204 is connected to by opening 207.It is described
Delivery pipe 205 (it can be wavy) can carry the finally solution (for example, PRP) without using/discharging and leave the re-breathing room
And the solution is discharged into air.The distal end of the wavy delivery pipe 205 could attach to cleaning systems 206 or at one
Body is in the cleaning systems 206, to clean the material with biohazardous in the emission, and will after clean
The emission is discharged into air.In the example of the present invention, the cleaning systems 206 may include high efficiency particulate filter
(HEPA) 408 or succession of H EPA filters.HEPA filters are drifted by wind thin to be generally used for preventing in a variety of biomedical applications
The distribution of bacterium and viral organism.The combination of any kind of HEPA filters or HEPA filters can be used.In instances,
HEPA strainer covers can be positioned at the far-end of the pipe 205.Fig. 2 B are the strainer cover according to the embodiment of the present invention
Schematic diagram.The strainer cover 250 can be positioned at the far-end of the pipe 205 of Fig. 2A.The strainer cover 250 can
Two HEPA filters 252,254 are combined, and the filter is held on or without the activated charcoal net 260 of silicon pillow
Between 252 and 254.The activated carbon net 260 can increase the efficiency of HEPA filter systems, and silicon pillow can be will be cleaned
Emission be discharged into before air and absorb any moisture.
Referring again to Fig. 2A, at the far-end and/or the opening 207 of the wavy delivery pipe 205
HEPA filters can also generate faint back pressure, and the back pressure allows to generate turbulent flow in the re-breathing room 204, can facilitate
The fog (for example, atomized soln) is recycled to sufferer.
In another example, as the supplement or alternative to HEPA filters, height can be used in the cleaning systems 206
Energy ultraviolet unit and/or heating coil, (such as to be blocked by filter media to any material with biohazardous
Material) carry out disinfection.Certainly, those skilled in the art will appreciate that, can be in the cleaning systems 206 alone or in combination
Ground uses a variety of other types of filters and mechanism.
Fig. 3 is the schematic diagram according to another example of the breathing apparatus comprising head band of the embodiment of the present invention.It can
The breathing mask 201 is fastened to sufferer using anaesthetic mask head band 301.It can be used in the different instances of the present invention
Various respiratory mask and head band configuration.Usually, fog can be advantageously reduced or eliminate using breathing mask to be lost to greatly
In gas.Suitable mask including but not limited to, transparent plastic oxygen mask, anaesthetic mask and soft mask made of PVC, example
Such as it is used to treat the soft mask of sleep apnea.In some instances, the mask can be lined with charcoal, be passed through with secondary
Exhalation air and/or atomized soln through breathing out or escaping.In some instances, one or more mistakes can be provided in the mask
Filter, the atomized soln with secondary through exhalation air and/or through breathing out or escaping.Anaesthetic mask head band 301 can be used
In the mask 201 is fastened to the sufferer.It may make using the anaesthetic mask with head band 301 and the mask relax
The face in sufferer is worn suitablely, while any fog (for example, atomization PRP) being prevented to be lost to air.In addition, head band can
Sufferer is allowed to execute other actions, because the both hands of the sufferer are constrained not due to being immobilizated on the mask, this can
Increase sufferer biddability.The head band 301 shown in Fig. 3 includes the first band 305, will be under the mask 201
Portion is connected to the support element 310 on the back of head of the sufferer.The head band 301 includes second strip 312, will be described
The top of mask 201 is connected to the support element 310.Similarly, in the face (in Fig. 3 invisible) of the mask and the sufferer
Opposite side on the support element between tool there are two band.Via providing the support element on the back of head of the sufferer
310, and have from the support element 310 to the mask 201 and amount to four bands, therefore the mask 201 and the sufferer
Face between can maintain firmly to seal.In some instances, the support element 310 and the band 312 can be by flexible materials
Be made and can perforated so that the skin feel for sufferer is comfortable.
Fig. 4 is the schematic diagram according to another example of the breathing apparatus comprising sprayer of the embodiment of the present invention.With reference to
Fig. 4 is painted the example of the breathing apparatus 400 with sprayer 401 in figure.The breathing apparatus similar with Fig. 2 to 3 shown in figure
400 component system is identified with similar reference number, and for simplicity, the component will not be described.The breathing apparatus 400
Including sprayer 401, is attached to the breathing apparatus 400 or integral with the breathing apparatus 400, as shown in Figure 4.
The sprayer 401 includes injection port 402, to inject solution to be atomized (for example, PRP solution).The injection port 402
It can be aseptic injection port, allow to inject sterile solution and/or compound.As well-known in technique, usable spray
Day with fog delivers the drug of the mist form for being sucked into lung.Second port 410 can be provided, and (it is different from the dispensing end
Mouth is 402) to allow gas into the sprayer 401.For example, can be by oxygen delivery to the sprayer 401, so that holding
It the solution atomization that is contained in the sprayer 401 and/or is introduced into the sprayer 401 by the injection port 402.Cause
In some instances the sprayer for entering port at least two can be used, one of port that enters is for making gas in this
Into to facilitate pneumatic spraying and another solution or compound entrance for entering port and allowing (for example, PRP) to be atomized.
In the example of the present invention, the sprayer 401 is for making solution atomization (for example, PRP solution), to be delivered to disease
Suffer from.Any suitable sprayer can be used, including pneumatic nebulizer or ultrasonic sprayer.The pneumatic nebulizer may need
Want a kind of driving force that pressurized gas source is required as liquid atomization.In the example of the present invention, it can be delivered and be pressed by plastic tube
Contracting oxygen is described to the sprayer 401 (for example, passing through the port 410) comprising the solution (for example, PRP solution)
Solution is sucked through spraying at fog, and by sufferer.In another example, ultrasonic sprayer, wherein ultrasonic wave can be used to pass through
The solution (for example, PRP solution), so that the solution atomization.For ultrasonic sprayer, it may not be necessary to the port 410.
The delivering of atomization PRP may induce inflammation due to being directly absorbed in the lung of sufferer.As described above, sucking atomization PRP is molten
Liquid can advantageously treat respiratory disease without causing the side effect present in Steroid treatment.
In some instances, the sprayer 401 can be integral with one or more other components shown in Fig. 4.For example,
The sprayer 401 can be integral with the connector tube 202.In some embodiments of the invention, it is possible to provide have through matching
The sprayer set the port to be connected to breathing mask and be configured to the port being connect with re-breathing bag.The sprayer can have
There are two entering port, one of which is sterile to enter port and another port that enters is for allowing gas for inject PRP
Into, so that the gas atomization, as shown in Figure 4.
Fig. 5 is the schematic diagram according to another example of the breathing apparatus comprising PEEP valves of the embodiment of the present invention.Equally
Ground illustrates that similar component has similar reference number, and similar component not describes again herein in Fig. 2 to 4.
The heating coil with fan 501 can be provided in the far-end, to implement the cleaning systems 206, or the supplement cleaning
The embodiment of system 206.The heating coil, which can be used for destroying or reducing when the fan releases emission, has environment
The material of harmful property.End-expiratory positive pressure (PEEP) valve also can or alternatively be used for the described remote of the cleaning systems 206
The distalmost end of end or the breathing apparatus 500.PEEP valves can provide the resistance to exhalation stream, and for example, work as the breathing
Equipment 500 is for having relied on when the sufferer of lung ventilator, it may be advantageous to use the PEEP valves.
Fig. 6 is the schematic diagram according to the hand-held intake system of the embodiment of the present invention.Described in Fig. 2 to 5
Intake system is recycled to the example of the re-breathing room of sufferer comprising the air and/or atomized soln having for making exhalation.So
And example of the invention includes and does not include the intake system of re-breathing room.For example, can from Fig. 2 to 4 shown in the system
Any one remove described re-breathing room 204, and for example, the connector tube 202 of Fig. 2A may be connected to the delivery pipe
205。
The intake system of other configurations can also be used in the example of the present invention.For example, hand-held is real as shown in Figure 6
Example.Hand-held intake system 550 includes sprayer 552.The sprayer 552 may include aseptic injection port 553 (for example, with
In injection PRP or other solution to be atomized) and it is another enter port 554 (for example, for allow gas enter so that the spray
The solution in day with fog 552 or compound atomization).In some instances, the injection port 553, which may be present, can not also deposit
, and PRP or other compounds to be atomized or solution may be already provided in the sprayer 552.The sprayer 552
It may be connected to connector tube 560.The connector tube 560 further can be connected to spout 562 in one end and the other end is connected to
Lid 564.550 size of the intake system can be set so that sufferer can hold the system 550, for example, via described in fixing
Sprayer 552, the pipe 560 and or the spout 562 and hold the system 550.
The lid 564 may include one or more filters or component of cleaning systems, or one or more filterings described in
The example of one or more described filters or component is described above in device or unit replacement.During sucking, the spout
562 can take the mouth of sufferer to, and in some instances, and sufferer may not exhale into the system 550 (such as at some
It in example, is permeated through exhalation air and/or solution when the lid 564 is permissible).In other examples, the sufferer can pass through
The spout 562 breathes out drug into the system 550.In some instances, can be replaced with mask the spout 562 or
The spout is connected to the mask, the example of the mask has been described above.
In other examples, example (such as the institute of the sprayer 552 of Fig. 6 or Fig. 5 of sprayer as described herein
State sprayer 401) pipe (for example, flexible pipe) is can be connected to, the pipe may be connected to lung ventilator.By this method, PRP or other
The solution or compound of atomization can be delivered to sufferer in lung ventilator (in some instances, including tracheotomy tube).
In some instances, the sprayer 552 can be integral with the connector tube 560.Therefore, in some examples
In, the sprayer 552 can have the output port for being configured to connect to spout or mask and be configured to connect to again
Another output port of breathing bag and/or exhalation pipe or filter.
Fig. 7 is the flow chart according to the method treated using breathing apparatus of the embodiment of the present invention.Fig. 7 illustrates this
The example of invention includes multiple steps using PRP Solution In The Treatment respiratory diseases, however, as described above, can also be similar
Method treatment Other diseases or the other solution of delivering.Once nursing staff's identification of breathing systemic disease is then taken out from sufferer
Peripheral veins blood is taken, to start to treat, as shown in frame 601.In other examples, also can additionally or alternatively use venous blood or
Arterial blood.In some instances, it is not necessarily to identification of breathing systemic disease, you can start to treat.The example of the present invention can advantageously make
It is treated without externally applied drug with the blood of sufferer itself.In other examples, other people blood can also be used, and/or
It can additionally or in addition use externally applied drug.
In instances, the peripheral veins blood that about 60cc can be used is treated.Can by the blood of the about 54cc extracted with
The anti-coagulants citrate dextrose sugar juice of 6cc to 8cc, solution A (ACD-A) are mixed and are centrifuged ten minutes with the speed of 3200rpm,
And lasting rotation in 10 minutes is carried out after the rise time, such as in block 602 shown in.The amount and parameter of noncentricity of blood can be based on
Used centrifugation technique and change, as known in the art.In frame 603, it is known in the art suitable to can be used
Technology collects PRP from through centrifuging solution.Existing or subsequent development commercial system that can be from blood sample, from any standard
Obtain PRP.
In general, blood sample can be centrifuged and obtains PRP and PRP can be used as the rich red blood cell through centrifugal blood
One layer between part and blood plasma.The PRP of about 6cc to 9cc (amount is depended on from the reached harvest rate of centrifugation) is collected, and
The platelet poor plasma (PPP) of 16cc to 19cc is about generated in an embodiment.For example, described PRP layers can be together with neighbouring blood
A part for some parts of pulp layer and/or the red blood cell layer is collected.In some instances, institute can be diluted with PPP
The PRP (about 6cc to 9cc) of collection, to reach the at most volume injected of 10cc in instances.In some instances, the PRP
It can be mixed with any collected platelet poor plasma and/or red blood cell.In block 604, the solution obtained can pass through
The injection port 402 is injected into the sprayer 401, to be atomized.It in the example of the present invention, also can be in injection institute
It states PRP solution and immediately passes through the platelet poor plasma that the injection port 402 injects about 10cc to 18cc later.In some realities
In example, according to therapeutic purpose, PRP and PPP solution is separably delivered or is delivered with different percentage.In frame 605,
It can make the PRP solution atomizations through injection, to generate the PRP of atomization, at frame 606, patient can inhale the PRP as fog
Enter.In the example using pneumatic nebulizer, it is possible to provide gas stream, to be atomized.For example, 8- can be provided in some instances
14 liters/or a small amount of of oxygen stream, to be atomized the solution and provide the oxygen of enough suckings.In some instances, oxygen can be auxiliary
The activation PRP is helped, this can increase therapy effect.PRP and the parts of plastics of used inhalation device in some instances
Contact can be used for activating the PRP.In general, activation PRP refers to the process for starting PRP growth hormone, this can assist increasing PRP
The therapy effect of sucking.
It, then can be in frame 607 optionally by any without making as sufferer continues to suck and breathe out the PRP solution through atomization
With and exhalation PRP solution capture in the re-breathing room 204.As described above, in some examples, (such as hand held system is real
Example) in, it can be not necessarily to provide re-breathing room.However, in some instances, in frame 607, the atomization without using and breathing out can be made
PRP recycling solutions return to the sufferer, therefore reduce PRP losses in some instances and increase the suction process
Effect and efficiency.In block 608, any residual emission can be carried to the cleaning systems 206 by the delivery pipe 205,
This cleans the residual emission via filtering or any other suitable technology, and discharges the emission after clean
To air.
It is as described herein to be atomized the system of PRP solution and using breathing apparatus to suffering from respiratory disease disease for delivering
The method that the sufferer of trouble is treated has a wide range of applications in living nature.For example, Steroid treatment is to suffering from respiratory system disease
The sufferer of disease is not proved effective, and sufferer also wishes to avoid the undesirable side effect of drug, or due to so of high cost that go against accepted conventions and nothing
Method is undertaken, these sufferers can benefit from system as described herein, equipment and the example for the treatment of.As described above, via inhalation delivery
PRP may include that the blood using sufferer itself is treated.The example of the present invention includes to be applied to a variety of symptom, including chronic resistance
Plug property tuberculosis, pulmonary bacterial or pulmonary viral infection (including H5N1, H1N1 and SARS), smoking damage caused by lung
Wound, late period respiratory disease, seasonal allergic reaction, nasosinusitis, pleurisy type pectoralgia, ischemic heart pain and general lung
Function.In view of the flexibility of the present invention, embodiment can be used in medical facilities, it can also be used to control at home sufferer
It treats.In addition, the present invention is not limited to deliver PRP solution, and can be used for via any solution of inhalation delivery, while can advantageously subtract
Few loss and increase delivery efficiency, while maintaining the chemicals for being discharged into air or substance minimum.
Fig. 8 is the schematic diagram according to another example of the breathing apparatus for delivering solution of the embodiment of the present invention.Ginseng
It sees Fig. 8, shows the example of the breathing apparatus 400 with cleaning systems 700.The similar component of breathing apparatus 400 uses the class of Fig. 4
It is shown like reference label, and is not described again the component herein for brevity.Cleaning systems 700 replace previous implementation
The cleaning systems 206 shown in example.Shown in embodiment as described, delivery pipe 205 may include positioned at the remote of delivery pipe 205
Cleaning unit 700 at end.Cleaning unit 700 can be cleaned before emission is discharged into air (for example, in some instances,
Disinfection) emission (such as may include PRP).In the illustrated embodiment, cleaning unit 700 include for clean and/
Or multiple filters of emission of the disinfection from re-breathing room 204.
In the illustrated embodiment of Fig. 9, cleaning systems 700 include multiple filter elements 705,710,715, the filtering
Device removes water droplet from the air stream discharged, and protecteds from cross contamination whereby and provides suffering from for effective tracheae humidification
The moisture of sufferer.More precisely, the combination of multiple filters 705,710,715 of cleaning systems 700 is minimum by evaporation loss
Change and the therefore humidification of auxiliary oxygen.In addition, cleaning systems 700 provide feature lower resistance to air stream with by the breathing of sufferer
Effect minimizes.
In one embodiment, filter element 705,710,715 includes standard antiviral humidifying filter, the filter
Water proofing property with the resistance degree optionally changed.In the illustrated embodiment of Fig. 9, filter element 705,710 is water proofing property
Antiviral humidifying filter and filter element 715 are the antiviral humidification of rain-proof with the gas sample port for emission analysis
Filter.
From above it is understood that although not departing from this in order to illustrate in this document describes the particular instances of the present invention
A variety of modifications can be carried out on the basis of the spirit and scope of invention, such as, but not limited to, for the ease of manufacturing and being convenient at sufferer
It sets, multiple components can be merged into single component.
Claims (15)
1. a kind of being delivered to personal system for will be enriched in thrombocyte plasma solution via sucking, the system comprises：
Sprayer, it includes the sterile ports for receiving the Platelet-rich plasm solution；
Connector tube is couple to the sprayer and is configured to the entrance port reception richness of the connector tube
The fog of the solution containing thrombocyte plasma；
Breathing mask is connected to the connector tube and is configured to the fog being delivered to the individual；
Re-breathing room is connected to the connector tube and is configured to receive the exhalation portion of the fog from the individual
Divide and exhalation at least some of part is made to be recycled back into the individual, the re-breathing room includes；
It is connected to the first end of the connector tube；And
The second end opposite with the first end；
Delivery pipe is connected to the second end of the re-breathing room in the proximal end of the delivery pipe and is configured to collect institute
State fog through discharge unit；And
Cleaning unit, is connected to the distal end of the delivery pipe, and the cleaning unit is configured to assist the steaming in the system
Hair loss, humidifies the oxygen across it and cleans the described through discharge unit of the fog whereby.
2. system according to claim 1, wherein the cleaning unit further comprises multiple filter units.
3. system according to claim 2, wherein the filter unit further comprises multiple antiviral humidification filterings
Device unit.
4. system according to claim 2, wherein distal end filter unit include to be configured for the gas of emissions analysis
Sampler body port.
5. system according to claim 1, wherein the breathing mask includes to be configured to fasten the breathing mask
To the head band of the individual.
6. system according to claim 2, wherein the head band, which is connected to, is configured for being positioned at the individual
Head the back side of head support element.
7. system according to claim 1, wherein the sprayer is pneumatic nebulizer.
8. system according to claim 4, wherein the sprayer is ultrasonic sprayer.
9. system according to claim 1, wherein the cleaning unit includes HEPA filters.
10. system according to claim 6, wherein the cleaning unit includes multiple HEPA filters being connected in series with.
11. system according to claim 6 further comprises another HEPA mistakes positioned at the distal end of the re-breathing room
Filter.
12. system according to claim 6 further comprises clear positioned at the ultraviolet light of the distal end of the HEPA filters
Clean unit.
13. system according to claim 1 further comprises the end-expiratory positive pressure positioned at the distal end of the cleaning unit
Valve.
14. system according to claim 1, wherein the cleaning unit includes a pair of HEPA filters and is placed in described
Activated charcoal net between HEPA filters.
15. system according to claim 11, wherein the cleaning unit, which further includes, is placed in the HEPA filterings
Silicon pillow between device for absorbing the moisture from the delivery pipe.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611141354.3A CN108607139A (en) | 2016-12-12 | 2016-12-12 | Thrombocyte plasma solution, which is will be enriched in, via sucking is delivered to personal system |
| JP2017114944A JP2018094375A (en) | 2016-12-12 | 2017-06-12 | Systems for administering platelet rich plasma solution by inhalation to individual |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611141354.3A CN108607139A (en) | 2016-12-12 | 2016-12-12 | Thrombocyte plasma solution, which is will be enriched in, via sucking is delivered to personal system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108607139A true CN108607139A (en) | 2018-10-02 |
Family
ID=62631505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611141354.3A Pending CN108607139A (en) | 2016-12-12 | 2016-12-12 | Thrombocyte plasma solution, which is will be enriched in, via sucking is delivered to personal system |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2018094375A (en) |
| CN (1) | CN108607139A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101501269A (en) * | 2006-07-19 | 2009-08-05 | 鲁昂大学 | Antiviral filter and use thereof in an air purifier, air conditioner or air humidifier |
| US8967141B2 (en) * | 2011-09-14 | 2015-03-03 | Brian Anthony Lemper | Inhalation systems, breathing apparatuses, and methods |
| CN205181952U (en) * | 2015-12-11 | 2016-04-27 | 高昌健 | Anesthesia exhaust emission device |
-
2016
- 2016-12-12 CN CN201611141354.3A patent/CN108607139A/en active Pending
-
2017
- 2017-06-12 JP JP2017114944A patent/JP2018094375A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101501269A (en) * | 2006-07-19 | 2009-08-05 | 鲁昂大学 | Antiviral filter and use thereof in an air purifier, air conditioner or air humidifier |
| US8967141B2 (en) * | 2011-09-14 | 2015-03-03 | Brian Anthony Lemper | Inhalation systems, breathing apparatuses, and methods |
| CN205181952U (en) * | 2015-12-11 | 2016-04-27 | 高昌健 | Anesthesia exhaust emission device |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018094375A (en) | 2018-06-21 |
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