CN108542358B

CN108542358B - Equipment and method for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging

Info

Publication number: CN108542358B
Application number: CN201810458226.4A
Authority: CN
Inventors: 秦建增
Original assignee: Guangzhou Zhongkang Zixun Co ltd
Current assignee: Guangzhou Zhongkang Zixun Co ltd
Priority date: 2018-05-14
Filing date: 2018-05-14
Publication date: 2023-04-25
Anticipated expiration: 2038-05-14
Also published as: CN108542358A

Abstract

The invention discloses equipment and a method for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging. The pulse condition sensor comprises a hydraulic control mechanism, a flexible transparent pulse-taking touch membrane, a hydraulic sensor, a laser transmitting head and an ultrasonic probe, wherein the laser transmitting head and the ultrasonic probe face the flexible transparent pulse-taking touch membrane, the hydraulic sensor is positioned in the watertight cabin, laser generated by the laser generator is synchronously transmitted to the three laser transmitting heads through optical fibers, and ultrasonic signals received by the three ultrasonic probes are transmitted to the ultrasonic receiver; the hydraulic pressure and finger pressure control mechanism, the hydraulic pressure sensor, the laser generator and the ultrasonic receiver are all connected with the central controller; the central controller is connected to the computer system. The invention can rapidly acquire seven-dimensional (three-dimensional form, time, mechanical characteristic, flow velocity and blood oxygen saturation) accurate information of the pulse condition.

Description

Equipment and method for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging

Technical Field

The invention relates to the technical field of traditional Chinese medicine pulse diagnosis automation, in particular to equipment and a method for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging.

Background

The pulse condition of traditional Chinese medicine contains rich biological information, and is an important content of four diagnostic methods of traditional Chinese medicine. The pulse refers to the appearance of the pulse (finger) and refers to the appearance and dynamics of the pulse. The formation of pulse conditions is closely related to qi and blood of viscera. Jing, wang-t He pulse channel summarize the pulse condition into twenty-four; ming-Li Shizhen (on the verge of lake pulse theory) is defined as twenty-seven pulses; ming-Li Shicai "Zhu Jia Zheng Yan" adds to the disease pulse and closes twenty-eight pulse conditions. Twenty-eight pulses are commonly used in the late stage.

The pulse condition element refers to the basic components of the pulse condition, including four aspects of position, number, shape and potential. The identification of the artificial pulse condition mainly depends on the feeling of the finger. The pulse condition is very various, and the Chinese medicine literature is often analyzed and summarized from four aspects of position, number, shape and potential, and is related to factors such as the frequency, rhythm, presented position, length and width of pulse, the fullness and tension of a vessel, the smoothness of blood flow, the strength and weakness of heart beat and the like. The control of the pulse condition elements can play a role in simplifying and controlling the formation mechanism and the characteristics of various pulse conditions.

One pulse bit: refers to the location and length of the pulse beat. Each time a pulse is diagnosed, the depth and length of the pulse manifestation should be examined. The normal pulse is not superficial and sinking, and the three pulses of cun, guan and chi are available. If the pulse is superficial, it is a superficial pulse; deep pulse refers to deep pulse; the pulse above the cun, guan and chi regions is a long pulse, while the pulse below the cun and chi regions is a short pulse.

Two pulse numbers: refers to the number and rhythm of pulse beats. Every pulse diagnosis should examine whether the pulse rate and rhythm are uniform. The frequency of the pulse is about 70-90 times per minute for normal adults, and the rhythm is uniform without stopping. For example, one-rest five to more than one pulse; one breath is not full of four to a delayed pulse; the intermittent pulse is the pulse that promotes the pulse, knots and pulses; uneven pulse rate is marked by irregular three-five pulse, and there are scattered pulse and astringent pulse.

Three pulse shapes: the pulse width and the like. Each time a pulse is diagnosed, the size, hardness, etc. of the pulse should be examined. The pulse shape is mainly related to factors such as the filling degree of the vessel, the amplitude of the pulse wave, etc. If the vessel is filled, the pulse with larger amplitude is a flood pulse; the pulse tube is smaller in filling degree, and the pulse amplitude is smaller as thin pulse; the poor elasticity of the vessel and the weak pulse are wiry pulses; soft and weak pulse can nourish the pulse and slow the pulse.

Four pulse potentials: the pulse refers to the trend of strong or weak pulse and smooth pulse. The pulse potential includes a variety of factors such as the axial and radial force of the pulsation; mainly the fluency created by heart and resistance effects; tension caused by the influence of vascular elasticity and tension, and the like. Each pulse diagnosis should examine the intensity and fluency of the pulse force. The normal pulse condition should mean mild and moderate. The strong pulse should be indicated; weak fingers are deficient pulses; the smooth state is good, and the smooth pulse is smooth; poor smooth condition, and difficult pulse condition, such as astringency.

The above is the basic element of pulse condition and the basic element of pulse condition observation. The pulse condition is distinguished mainly according to the feeling under the finger of the doctor, so that the doctor must repeatedly practice the feeling under the finger and carefully conduct physical examination, and the various pulse condition elements are integrated and analyzed to form a relatively complete pulse condition so as to accurately distinguish various diseased pulses.

Pulse diagnosis relies on the tactile function of the human finger tip. Human skin can sense a variety of sensations, such as touch, pain, heat, etc., with the sensation of touch being particularly important. Human touch is primarily perceived by 4 types of mechanoreceptors distributed in a large number of mechanoreceptors at different depths of the skin: the Meissner corpuscles in the superficial skin and the pericyclic corpuscles in the deep skin are fast adaptive receptors, the external stimulus with a narrow low-frequency dynamic range of 3-40 Hz can be responded quickly, and the sensing functions of low-frequency vibration, motion detection, grip strength control and the like are realized; the latter can quickly respond to external stimulus with wide dynamic range of 40-500+Hz high frequency, and realize the sensing functions of high frequency vibration, tool use and the like. In contrast, a mercer cell with short finger-like projections distributed between basal cells of the whole body epidermis and a long spindle Lu Feini small body in the dermis are slow adaptive receptors, which respond slowly by 0.4-3. The 0Hz low-frequency dynamic range is narrow, and the external stimulus such as spatial deformation, continuous pressure, curved surface, edge or sharp angle and the like can realize the sensory functions such as mode/form detection, texture perception and the like; the latter can slowly respond to external stimuli such as continuous downward pressure, transverse skin stretching, skin sliding and the like with a wide high-frequency dynamic range of 100-500+Hz, and realize the sensing functions such as finger position, stable grabbing, tangential force, movement direction and the like. According to the characteristics of haptic sensation, the haptic sensation can be classified into a sliding haptic sensation and a flexible haptic sensation. The sliding touch sense is a sense parallel to the contact surface of the finger and mainly reflects the geometric shape, texture, temperature and the like of the surface of the object; flexible touch is a dynamic perception in a direction perpendicular to the finger contact surface, primarily reflecting the flexibility or stiffness of the object. The distribution density of the touch receptors at each part of the human body is greatly different. 241 cm and 58cm are respectively distributed on fingertip and palm center of adult ² The tactile sensor makes the difference of the spatial resolution of each part of the human body obvious, the spatial resolution of the fingertip and the depth sense are 0.2mm and 0.5mm between two points, and the critical tactile response time of two events at different positions is 30-50 ms. Controllable pressure sensitivity studies indicate that: the normal pressure thresholds for the palm and fingertip of the male were on average about 0.158g and 0.055g, respectively, and the corresponding values for the female were 0.032g and 0.019g, respectively.

The pulse diagnosis of traditional Chinese medicine is the feeling of the finger tip of the middle doctor, and the density of the human finger tip receptor is the highest, so the pulse diagnosis of traditional Chinese medicine has rich information and high precision. To objectify pulse diagnosis in traditional Chinese medicine, the sensor needs to achieve certain indexes of human finger tip receptors in pulse diagnosis information acquisition, and can accurately distinguish different pulse conditions.

In the middle 50 s of the 20 th century, the scientific workers in the world of Chinese medicine, chinese and Western medicine and biomedical engineering began the objective study of the pulse conditions of Chinese medicine. Thereafter, people in japan, korea, united states, etc. are engaged in this work. In general, the objective study of pulse diagnosis is focused on the study of pulse condition detection sensors.

The traditional pulse detection method is finger palpation, which inevitably brings subjective factors, is inconvenient for objective recording and fine analysis, is difficult to inherit and innovate, and greatly limits the application and popularization of the pulse detection method. The sensor is used for detecting the pulse, so that the main information of the pulse can be objectively obtained, the pulse wave signal can be recorded, the storage and analysis are facilitated, the human body is not damaged, the use is convenient, and the method is widely applied in practice.

The pulse condition detection sensor creates a first lever type pulse recorder as early as Vierordt in 1860, and then development of the traditional Chinese medicine pulse recorder is fast at home and abroad, especially in the middle 70 s, the domestic Tianjin, shanghai, guizhou, jiangxi and the like sequentially form a interdisciplinary pulse condition research cooperation group, and the cooperation of multiple disciplines promotes the research of the traditional Chinese medicine pulse condition to enter a new boundary.

The pulse condition detection sensor has a plurality of patterns, including single part, three parts, single point, multiple points, rigid contact type, soft contact type, hydraulic type, silicon cup type, liquid mercury, liquid water, mother-son type and the like. The main elements of pulse probes are strain gages, piezoelectric crystals, monocrystalline silicon, photosensitive elements, PVDF piezoelectric films and the like, wherein single-point strain gages are the most widely used, but in recent years, three-point multi-point directions are being developed. However, the pulse sensors developed at home and abroad at present only can collect information on pulse pressure and pulsation and cannot represent other multidimensional information.

The objectification study of pulse diagnosis shows that the arterial pulse is not only the information of pressure pulsation, but also various information of lumen volume, blood flow speed, three-dimensional movement of vessel, namely four aspects of pulse condition such as position, number, shape and potential. The pressure pulse graph acquired by the traditional sensors such as the pressure sensor is difficult to quantitatively reflect the indexes of pulse condition components (some of the pressure pulse graphs are converted into three-dimensional images through multi-point pressure information, but the three-dimensional reconstruction is not accurate due to the fact that the acquisition points are insufficient and the accuracy of the pressure information is poor). Therefore, based on the existing pulse condition automatic analysis research results, the three-dimensional image acquisition technology, the artificial intelligence technology and the automatic control technology are fully utilized, the holographic synchronous acquisition of pulse condition information pressure, three-dimensional movement and other pulse conditions is realized, a solution is provided for realizing the objectification of pulse diagnosis of the traditional Chinese medicine, and the traditional Chinese medicine is promoted to inherit and innovate, so that the method has important significance.

In recent years, a pulse three-dimensional information acquisition method (CN 107468222A, CN 1927114A) based on structured light and binocular vision technology and a method adopting a sensor array are presented, but the methods cannot achieve enough precision, are difficult to realize miniaturization in technology and equipment, and cannot truly realize seven-dimensional information synchronous acquisition in the aspect of pulse information acquisition, so that a continuous improvement room exists.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide equipment and a method for automatically acquiring seven-dimensional information of a pulse condition based on photoacoustic imaging, which can quickly construct a precise and accurate dynamic three-dimensional image of the pulse condition, reflect the micro-changes of the pulse condition in mechanical characteristics, time dimension and space dimension (seven dimensions), and provide possibility for computer identification of complex traditional Chinese medicine pulse conditions.

In order to achieve the above purpose, the present invention adopts the following technical scheme:

the device for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging comprises three pulse condition sensors; each pulse condition sensor comprises a fixed shell, a flexible transparent pulse diagnosis touch film, a laser emitting head, a hydraulic sensor, an ultrasonic probe, a liquid inlet and outlet pipe and a watertight cabin upper cover; the flexible transparent pulse-taking touch membrane is arranged at the lower end of the fixed shell, the watertight cabin upper cover sealing cover is arranged at the upper part inside the fixed shell, the flexible transparent pulse-taking touch membrane, the watertight cabin upper cover and the fixed shell enclose a watertight cabin, and purified water is filled inside the watertight cabin; the two ends of the liquid inlet and outlet pipe are respectively communicated with the inside and the outside of the watertight cabin, the transmitting end of the laser transmitting head and the receiving end of the ultrasonic probe face the inner wall of the flexible transparent pulse diagnosis touch film, and the detecting end of the hydraulic sensor is positioned in the watertight cabin;

the liquid inlet and outlet pipes of each pulse condition sensor are communicated with the hydraulic control mechanism and are independently controlled by the hydraulic control mechanism; the up-and-down movement of each pulse condition sensor is independently controlled by an up-and-down movement control mechanism;

the ultrasonic device also comprises an ultrasonic receiver and a laser generator, wherein laser generated by the laser generator is transmitted to the laser transmitting head, and ultrasonic information received by the ultrasonic probe is transmitted to the ultrasonic receiver;

the system also comprises a central controller, wherein the hydraulic sensor, the hydraulic control mechanism, the up-down movement control mechanism, the laser generator and the ultrasonic receiver are all connected with the central controller; the central controller is connected to the computer system.

Further, the laser generator and the ultrasonic receiver are one, the ultrasonic probes in the three pulse condition sensors are connected with the ultrasonic receiver, and the laser emitting heads in the three pulse condition sensors are connected with the laser generator through optical fibers.

Further, the flexible transparent pulse-touch membrane is hollow hemispherical.

Further, the device for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging further comprises an outer shell, three pulse condition sensors are arranged at the lower part of the outer shell, and a flexible transparent pulse diagnosis touch film of each pulse condition sensor is exposed downwards to the outside of the outer shell; the hydraulic control mechanism, the up-down movement control mechanism, the laser generator, the ultrasonic receiver and the central controller are all arranged in the outer shell.

Further, the hydraulic control mechanism is a hydraulic pump, each liquid inlet and outlet pipe is respectively communicated with the hydraulic pump through an independent channel, and the hydraulic pump respectively and independently adjusts liquid inlet and outlet amounts of the three channels.

Further, the up-and-down movement control mechanism comprises an up-and-down movement control hydraulic pump and a finger pressure controller, and each pulse condition sensor is respectively provided with the finger pressure controller; each finger pressure controller comprises a pulse condition sensor sleeve, a hydraulic device piston, a piston sleeve and an up-and-down movement control liquid inlet and outlet pipe, wherein the pulse condition sensor is arranged in the pulse condition sensor sleeve, and the hydraulic device piston is arranged in the piston sleeve and connected to the top of a fixed shell of the pulse condition sensor; the two ends of the up-and-down movement control liquid inlet and outlet pipe are respectively communicated with the interior of the piston sleeve and the up-and-down movement control hydraulic pump; all the up-and-down movement control liquid inlet and outlet pipes of the finger pressure controller are respectively and independently communicated with the up-and-down movement hydraulic pump through independent channels, and the hydraulic pump is used for independently controlling the liquid inlet and outlet amount of each channel.

Further, the equipment for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging further comprises a pulse diagnosis platform, wherein the pulse diagnosis platform mainly comprises a forearm bracket and an automatic pulse condition locator; the automatic locator of the pulse condition instrument comprises a camera, a position adjusting controller and a triaxial platform; the three-axis pulse condition sensor is arranged on the three-axis platform, the camera is used for capturing images of the wrist part of the human body and transmitting the images to the position adjustment controller, and the position adjustment controller is used for controlling the three-axis platform to drive the three pulse condition sensors to move in the three-axis direction so as to align the positions of the cun, guan and chi pulses of the wrist part of the human body.

The method for acquiring the pulse condition information by using the device for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging comprises the following steps:

s1, three pulse condition sensors are adjusted to the positions of cun, guan and chi pulses of the wrist of a human body;

s2, the central controller controls the operation of the hydraulic control mechanism, the up-down movement control mechanism, the ultrasonic receiver and the laser generator and receives data from the hydraulic sensor and the ultrasonic receiver, wherein:

the central controller controls the hydraulic control mechanism to respectively adjust the water pressure in the watertight cabins of the three pulse condition sensors to a target value according to the pressure value in the watertight cabin fed back in real time by the hydraulic sensor of each pulse condition sensor so as to adjust the tension of the flexible transparent pulse diagnosis touch film according to the light, medium and heavy finger methods of the cun, guan and chi pulse;

the central controller controls the up-down movement control mechanism to drive the three pulse diagnosis sensors to move up and down respectively so as to adjust the light, medium and heavy fingering of the cun, guan and chi pulse;

the laser generator generates laser, the laser is synchronously transmitted to laser emission heads of three pulse-taking sensors through optical fibers, the laser enters into tissues at the radial artery after passing through water in a watertight cabin and a flexible transparent pulse-taking touch film, and irradiates oxyhemoglobin in the radial artery, the oxyhemoglobin is sensitive to the laser, the condition of structural expansion occurs, so that an ultrasonic signal is generated, and the ultrasonic signal is received by an ultrasonic probe and then transmitted into an ultrasonic receiver;

the ultrasonic signals acquired by the ultrasonic receiver and the pressure value in the current watertight compartment measured in real time by the hydraulic sensor are simultaneously transmitted to the central controller, and the central controller is simultaneously transmitted to the computer system;

s3, when the pressure in the watertight cabin is regulated to different pressures, the shape of the blood vessel is changed when the blood vessel fluctuates, the flowing blood body is changed, the ultrasonic signal received by the ultrasonic probe is also changed, a three-dimensional image sequence with the pulse changing along with time is formed through the processing of the computer system, then the computer system combines the pressure data of the corresponding time points to form seven-dimensional information data of the pulse condition, namely corresponding time information, pressure information, three-dimensional image information, blood flow velocity information and blood oxygen saturation information, and the pulse condition information is identified and analyzed.

In step S1, after the patient places the wrist on the forearm support of the pulse-taking platform, the position adjustment controller controls the camera of the automatic positioner of the pulse-taking device to take a photograph of the wrist, the position adjusting controller identifies the photo of the wrist and then positions the position of the cun, guan and chi pulse, and controls the triaxial platform to drive the three pulse condition sensors to automatically move to the positions of the cun, guan and chi pulse of the wrist according to the position; after the flexible transparent pulse touch film of the pulse condition sensor touches the skin, the pressure in the watertight compartment can be changed, the hydraulic sensor transmits the pressure data measured in real time to the central controller, the central controller transmits the pressure data to the computer system, and the positioning is completed after the fluctuation of the pressure of the watertight compartment is detected.

In step S2, the specific process of driving the three pulse-taking sensors to move up and down by the up-and-down movement control mechanism is as follows:

the up-and-down movement control hydraulic pump drives the hydraulic device piston to move up and down by controlling the liquid inlet or liquid outlet of each piston sleeve, so as to drive the pulse condition sensor connected with the hydraulic device piston to move up and down in the pulse condition sensor sleeve, and simulate the light, middle and heavy fingering of three fingers of pulse diagnosis and different combinations of the three fingering.

The invention has the beneficial effects that:

1. when the pulsed laser irradiates biological tissue, an absorber positioned in the tissue absorbs the energy of the pulsed light, and the pulsed light is heated up instantaneously and swells to generate ultrasonic waves. An ultrasound probe at the surface of the tissue volume can then receive these externally transmitted ultrasound waves and reconstruct an image of the light energy absorption distribution within the tissue from the detected ultrasound signals. The organic combination of optical imaging and acoustic imaging can provide tissue tomographic images with high resolution and high contrast of deep tissues, avoid the influence of light scattering in principle, break through the soft limit (about 1 mm) of the high-resolution optical imaging depth and realize the deep in-vivo tissue imaging of 50 mm.

Photoacoustic imaging combines the advantages of optical imaging and ultrasonic imaging, on the one hand, the signal used for reconstructing an image in photoacoustic imaging is an ultrasonic signal, and the scattering of ultrasonic signals by physiological tissues is 2-3 orders of magnitude lower than that of the optical signals, so that deeper imaging depth and higher spatial resolution can be provided; on the other hand, the optical contrast between different tissues in a photoacoustic image is higher than that of pure ultrasound imaging.

The photoacoustic imaging has the following characteristics: (1) The photoacoustic imaging can realize the selective excitation of high-specificity spectral tissues, can reflect the structural characteristics of the tissues, can realize functional imaging, and initiates a novel imaging method and technical means different from the traditional medical imaging technology. (2) The photoacoustic imaging combines the advantages of optical imaging and acoustic imaging, and can break through the soft limit of high-resolution optical imaging depth such as laser confocal microscopic imaging, two-photon excitation microscopic imaging, optical weak coherence tomography and the like; on the other hand, the imaging device has higher resolution, the resolution of the image can reach submicron and micron level, and high-resolution molecular imaging can be realized. (3) Photoacoustic imaging is a non-invasive, non-ionizing, atraumatic imaging technique. Therefore, as an emerging medical imaging technology, lossless photoacoustic imaging obtains high enough resolution and image contrast at a certain depth, and the transmitted information of the image is large, so that morphological and functional information can be provided.

Hemoglobin in blood vessels is a substance having strong optical absorption characteristics, and information of these absorbers can be evaluated by using the photoacoustic effect, thereby obtaining information of blood vessels. The axial resolution of the current photoacoustic detection device at the depth of 30mm can reach 0.01mm, the transverse resolution can reach 0.5 mu m, the thinnest capillary vessel in the body can be detected, and even single red blood cells can be observed. In addition, the photoacoustic imaging speed is high, and can reach 50 frames/second at present, and the photoacoustic imaging method can be used for researching the track of a moving object, so that the blood flow speed and viscosity information can be accurately measured. Hemoglobin is classified into oxyhemoglobin and deoxyhemoglobin, which react differently to laser light, so that the blood oxygen saturation can also be quantitatively measured.

The invention adopts the photoacoustic imaging technology, not only can obtain high-precision three-dimensional motion information of blood vessels, but also can synchronously obtain blood oxygen saturation information and blood flow velocity information, can rapidly, accurately and effectively synchronously obtain seven-dimensional information of pulse conditions, and breaks through the limitation of the traditional pulse diagnosis instrument.

2. A single sensor of a traditional piezoelectric sensor array (PVDF piezoelectric film and the like) is 1mm at minimum, the minimum printing precision of printing patterns on the inner wall of a flexible hemisphere and photographing by adopting binocular vision theory is 0.5mm (exceeding the precision, a camera cannot accurately photograph), and the width of a radial artery is about 2mm, so that the two traditional methods for obtaining three-dimensional pulse condition information have insufficient data precision, the number of points for acquiring the pulse cross section is only 2-4, a three-dimensional model cannot be basically reconstructed, and the morphological characteristics of the pulse condition (the twenty-eight pulse condition difference of traditional Chinese medicine is extremely fine) cannot be accurately reflected. The invention directly images the oxyhemoglobin in the red blood cells filled in the vessel, thereby recording the three-dimensional shape, blood flow velocity and blood oxygen saturation information of the vessel in real time. The axial resolution of the method can reach 0.01mm, the transverse resolution can reach 0.5 mu m, the measurement speed can reach 50 frames/second, the micro change of the pulse condition in the time dimension and the space dimension can be reflected, and the method provides possibility for computer recognition of complex traditional Chinese medicine pulse conditions.

3. The pulse diagnosis requires three nine pieces of information, namely cun, guan and chi, each of which is marked by the force of light, medium and heavy fingers according to the pulse (three pieces of information), which are marked by the force of floating, medium and heavy fingers, three to nine pieces of information (difficult menstruation, eighteen difficulties), and the comparison of the three pieces of information with each other, the whole set of pulse diagnosis finger method includes: one part is pressed lightly, moderately and heavily, and the other two parts are pressed lightly, moderately and heavily respectively, namely 3 x 3 on one side, 27 fingering methods are added, and 54 fingering methods are added on two sides. Therefore, the objective device for pulse diagnosis must solve the problem that three parts of diagnosis pulse are separated, and each part can realize pressing pulse with light, medium and heavy finger force.

The invention simulates the light, medium and heavy pulse taking technique of pulse diagnosis by independently controlling and adjusting the positions of the three pulse condition sensors, synchronously realizes the three and nine pulse diagnosis techniques, and obtains more comprehensive information.

4. Pulse condition dynamic characteristics and morphological characteristics are synchronously acquired: the hydraulic sensor is arranged in the watertight cabin to directly measure pulse pressure, and the three-dimensional image information and the hydraulic data of the pulse condition are synchronously acquired and synchronously transmitted, so that the seven-dimensional information (time information, hydraulic information, three-dimensional image information, blood flow speed and blood oxygen saturation information) of the pulse condition is synchronously acquired, and the comprehensive accuracy of the pulse condition information is ensured.

5. The automatic positioning of the pulse condition sensor is realized by combining the image recognition technology, so that the degree of automation of pulse diagnosis is further improved.

6. The miniaturization problem of the sensor is solved by adopting the optical fiber conduction technology.

Drawings

FIG. 1 is a schematic diagram of the overall structure of an implementation of the present invention;

FIG. 2 is a schematic diagram of the pulse condition sensor in FIG. 1;

FIG. 3 is a schematic diagram of the finger pressure controller of FIG. 1;

FIG. 4 is a schematic diagram of a pulse-taking platform according to an embodiment of the present invention;

FIG. 5 is a schematic view of photoacoustic imaging of the radial artery, the patent, and the ulnar artery of a single frame;

fig. 6 is a schematic view of three-dimensional reconstruction of photoacoustic imaging of multiple radial artery cun, guan and ulna regions.

Detailed Description

The present invention will be further described with reference to the accompanying drawings, wherein the following examples are provided on the premise of the present technical solution, and detailed embodiments and specific operation procedures are given, but the scope of the present invention is not limited to the examples.

As shown in fig. 1 to 4, the apparatus for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging includes three pulse condition sensors 1 for acquiring pulse condition information of a ulnar pulse, a guan pulse and an cun pulse, respectively.

Each pulse condition sensor 1 comprises a fixed shell 11, a flexible transparent pulse-taking touch membrane 12, a laser emitting head 13, a hydraulic sensor 14, an ultrasonic probe 15, a liquid inlet and outlet pipe 16 and a watertight compartment upper cover 17; the flexible transparent pulse-taking touch membrane 12 is arranged at the lower end of the fixed shell 11, the watertight cabin upper cover 17 is sealed and arranged at the upper part inside the fixed shell 11, and the flexible transparent pulse-taking touch membrane 12, the watertight cabin upper cover 17 and the fixed shell 11 enclose a watertight cabin 18; the two ends of the liquid inlet and outlet pipe 16 are respectively communicated with the inside and the outside of the watertight compartment 18, the emitting end of the laser emitting head 13 and the receiving end of the ultrasonic probe 15 face the inner wall of the flexible transparent pulse-taking touch membrane 12, and the detecting end of the hydraulic sensor 14 is positioned in the watertight compartment 18.

In the present embodiment, the ultrasonic probe 15, the laser emitting head 13, the liquid inlet and outlet pipe 16, and the hydraulic pressure sensor 14 are all fixed to the watertight compartment upper cover 17.

The liquid inlet and outlet pipe 16 in each pulse condition sensor 1 is communicated with and independently controlled by the hydraulic control mechanism, and the up-and-down movement of each pulse condition sensor 1 is independently controlled by the up-and-down movement control mechanism.

The ultrasonic device also comprises an ultrasonic receiver 2 and a laser generator 3, wherein laser generated by the laser generator 3 is transmitted to a laser transmitting head 13, and the ultrasonic probe 15 is transmitted to the ultrasonic receiver 2.

In this embodiment, the ultrasonic receiver 2 and the laser generator 3 are both one, the ultrasonic probe 15 in each pulse condition sensor 1 is connected to the ultrasonic receiver 2 through an optical fiber, and the laser emitting head 13 in each pulse condition sensor 1 is connected to the laser generator 3 through an optical fiber. The laser generated by the laser generator 3 is synchronously transmitted to the three laser emission heads 13 through optical fibers, and ultrasonic signals acquired by the three ultrasonic probes 15 enter the same ultrasonic receiver 2, so that the synchronous shooting of a picture of cun, guan and chi pulses can be ensured.

The system also comprises a central controller 4, wherein the hydraulic control mechanism, the up-and-down movement control mechanism, the laser generator 3, the ultrasonic receiver 2 and the hydraulic sensors 14 in each pulse-taking sensor are all connected with the central controller 4; the central controller 4 is connected to a computer system.

Still further, the flexible transparent pulse-touch membrane 12 is hollow hemispherical. The flexible transparent pulse touch membrane is made of flexible materials and is in a hollow hemispherical shape, and the appearance of the flexible transparent pulse touch membrane is more similar to the shape of a finger touch pulse.

Further, the pulse condition sensor comprises an outer shell 5, three pulse condition sensors 1 are arranged at the lower part of the outer shell 5, and a flexible transparent pulse diagnosis touch film 12 of each pulse condition sensor 1 is exposed downwards outside the outer shell 5; the hydraulic control mechanism, the up-and-down movement control mechanism, the laser generator 3, the ultrasonic receiver 2 and the central controller 4 are all arranged in the outer shell 5.

Further, the hydraulic control mechanism is a hydraulic pump 6, each liquid inlet and outlet pipe 16 is respectively communicated with the hydraulic pump 6 through an independent channel, and the hydraulic pump 6 independently adjusts liquid inlet and outlet amounts of the three channels. The hydraulic pump independently adjusts the pressure in the watertight compartment of the three pulse-taking sensors 1 by independently adjusting the liquid inlet and outlet amounts of the three channels.

Further, the up-and-down movement control mechanism comprises an up-and-down movement control hydraulic pump 7 and a finger pressure controller 8, and each pulse condition sensor 1 is respectively provided with the finger pressure controller 8; the finger pressure controller 8 comprises a pulse condition sensor sleeve 81, a hydraulic device piston 82, a piston sleeve 83 and an up-and-down movement control liquid inlet and outlet pipe 84, wherein the pulse condition sensor 1 is arranged in the pulse condition sensor sleeve 81, and the hydraulic device piston 82 is arranged in the piston sleeve 83 and is connected to the top of a fixed shell 11 of the pulse condition sensor 1; both ends of the up-and-down movement control liquid inlet and outlet pipe 84 are respectively communicated with the inside of the piston sleeve 83 and the up-and-down movement control hydraulic pump 7; the three up-and-down movement control liquid inlet and outlet pipes 84 are respectively and independently communicated with the up-and-down movement control hydraulic pump 7 through independent channels, and the up-and-down movement control hydraulic pump 7 independently controls the liquid inlet and outlet amounts of the three channels.

Further, the device also comprises a pulse diagnosis platform which mainly comprises a forearm bracket 9 and an automatic locator of the pulse meter; the automatic locator of the pulse condition instrument comprises a camera (not shown), a position adjustment controller (not shown) and a triaxial platform 10; the pulse condition sensors are mounted on the three-axis platform (in this embodiment, the outer casing 5 is fixed on the three-axis platform), the camera is used for capturing images of the wrist part of the human body and transmitting the images to the position adjustment controller, and the position adjustment controller is used for controlling the three pulse condition sensors to move in the three-axis direction by the three-axis platform so as to align the positions of the cun, guan and chi pulses of the wrist part of the human body.

the laser generator generates laser, the laser is synchronously transmitted to the laser transmitting heads of the three pulse diagnosis sensors through optical fibers, the laser enters the tissue at the radial artery after passing through water in the watertight cabin and the flexible transparent pulse diagnosis touch film, irradiates oxyhemoglobin in the radial artery, and generates structural expansion due to the sensitivity of the oxyhemoglobin to the laser with specific wavelengths (absorption peaks of the hemoglobin are near 280nm, 420nm, 540nm and 580 nm), ultrasonic signals are generated, and the ultrasonic signals are received by the ultrasonic probe and transmitted into the ultrasonic receiver.

The ultrasonic signals acquired by the ultrasonic receiver and the pressure data in the current watertight compartment measured in real time by the hydraulic sensor are simultaneously transmitted to the central controller, and the central controller is simultaneously transmitted to the computer system;

s3, when the pressure in the watertight cabin is regulated to different pressure values, the shape of the blood vessel changes when the blood vessel fluctuates, the flowing blood body changes, an ultrasonic signal received by ultrasonic waves changes, a three-dimensional image sequence with the pulse changing along with time is formed through the processing of a computer system, then the computer combines the pressure data of corresponding time points to form seven-dimensional information data of pulse conditions, wherein the seven-dimensional information data comprises corresponding time information, pressure information, three-dimensional image information, blood flow velocity information and blood oxygen saturation (blood oxygen saturation) information, and the pulse condition information is identified and analyzed.

Fig. 5 is a schematic view of photoacoustic imaging of radial artery, off and ulna parts in a single frame, and fig. 6 is a schematic view of three-dimensional reconstruction of photoacoustic imaging of radial artery, off and ulna parts in multiple frames.

In step S1, after the patient places the wrist on the forearm bracket of the pulse diagnosis platform, the position adjustment controller controls the camera of the automatic locator of the pulse condition instrument to take a picture of the wrist, the position adjustment controller identifies the picture of the wrist and then positions the position of the cun, guan and chi pulse, and controls the triaxial platform to drive the three pulse condition sensors to automatically move to the cun, guan and chi pulse positions of the wrist; after the flexible transparent pulse touch film of the pulse condition sensor touches the skin, the pressure in the watertight compartment can be changed, the hydraulic sensor transmits the pressure data measured in real time to the central controller, the central controller transmits the pressure data to the computer system, and when the fluctuation of the pressure of the watertight compartment (namely the fluctuation of pulse) is detected, the positioning is completed.

Specifically, the computer system identifies the position of the radius styloid process (styloid process of radius) through the photo of the wrist and determines the pulse-taking location, so that the pulse-taking location method of traditional Chinese medicine' the palm high bone is on the head, the head is on the tail, the head is on the foot, the foot is on the foot, and the foot is on the foot, so that the pulse-taking location is correctly located.

the hydraulic pump drives the hydraulic device piston to move up and down by controlling the liquid inlet or liquid outlet of each piston sleeve, so as to drive the pulse condition sensor connected with the hydraulic device piston to move up and down in the pulse condition sensor sleeve, and simulate the light, middle and heavy finger methods of three fingers of pulse diagnosis and different combinations of the three finger methods.

Various modifications and variations of the present invention will be apparent to those skilled in the art in light of the foregoing teachings and are intended to be included within the scope of the following claims.

Claims

1. The device for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging comprises three pulse condition sensors; the pulse condition sensor is characterized by comprising a fixed shell, a flexible transparent pulse diagnosis touch film, a laser emission head, a hydraulic sensor, an ultrasonic probe, a liquid inlet and outlet pipe and a watertight cabin upper cover; the flexible transparent pulse-taking touch membrane is arranged at the lower end of the fixed shell, the watertight cabin upper cover sealing cover is arranged at the upper part inside the fixed shell, the flexible transparent pulse-taking touch membrane, the watertight cabin upper cover and the fixed shell enclose a watertight cabin, and purified water is filled inside the watertight cabin; the two ends of the liquid inlet and outlet pipe are respectively communicated with the inside and the outside of the watertight cabin, the transmitting end of the laser transmitting head and the receiving end of the ultrasonic probe face the inner wall of the flexible transparent pulse diagnosis touch film, and the detecting end of the hydraulic sensor is positioned in the watertight cabin; the ultrasonic probe, the laser emission head, the liquid inlet and outlet pipe and the hydraulic sensor are all fixed on the watertight cabin upper cover;

2. The device for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging of claim 1, wherein the laser generator and the ultrasonic receiver are one, the ultrasonic probes in the three pulse condition sensors are connected to the ultrasonic receiver, and the laser emitting heads in the three pulse condition sensors are connected to the laser generator through optical fibers.

3. The device for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging of claim 1, wherein the flexible transparent pulse-taking touch membrane is in a hollow hemispherical shape.

4. The device for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging according to claim 1, further comprising an outer housing, wherein three pulse condition sensors are arranged at the lower part of the outer housing, and a flexible transparent pulse diagnosis touch film of each pulse condition sensor is exposed downwards outside the outer housing; the hydraulic control mechanism, the up-down movement control mechanism, the laser generator, the ultrasonic receiver and the central controller are all arranged in the outer shell.

5. The apparatus for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging according to claim 1, wherein the hydraulic control mechanism is a hydraulic pump, each of the liquid inlet and outlet pipes is communicated with the hydraulic pump through an independent channel, and the hydraulic pump independently adjusts the liquid inlet and outlet amounts of the three channels.

6. The apparatus for automatically acquiring seven-dimensional information of a pulse condition based on photoacoustic imaging according to claim 1, wherein the up-down movement control mechanism comprises an up-down movement control hydraulic pump and a finger pressure controller, each pulse condition sensor being respectively provided with the finger pressure controller; each finger pressure controller comprises a pulse condition sensor sleeve, a hydraulic device piston, a piston sleeve and an up-and-down movement control liquid inlet and outlet pipe, wherein the pulse condition sensor is arranged in the pulse condition sensor sleeve, and the hydraulic device piston is arranged in the piston sleeve and connected to the top of a fixed shell of the pulse condition sensor; the two ends of the up-and-down movement control liquid inlet and outlet pipe are respectively communicated with the interior of the piston sleeve and the up-and-down movement control hydraulic pump; all the up-and-down movement control liquid inlet and outlet pipes of the finger pressure controller are respectively and independently communicated with the up-and-down movement hydraulic pump through independent channels, and the hydraulic pump is used for independently controlling the liquid inlet and outlet amount of each channel.

7. The device for automatically acquiring seven-dimensional pulse condition information based on photoacoustic imaging of claim 1, further comprising a pulse diagnosis platform, wherein the pulse diagnosis platform mainly comprises a forearm bracket and an automatic pulse condition positioner; the automatic locator of the pulse condition instrument comprises a camera, a position adjusting controller and a triaxial platform; the three-axis pulse condition sensor is arranged on the three-axis platform, the camera is used for capturing images of the wrist part of the human body and transmitting the images to the position adjustment controller, and the position adjustment controller is used for controlling the three-axis platform to drive the three pulse condition sensors to move in the three-axis direction so as to align the positions of the cun, guan and chi pulses of the wrist part of the human body.

8. The method for acquiring the pulse condition information by using the device for automatically acquiring the seven-dimensional pulse condition information based on the photoacoustic imaging according to any one of the previous claims, which is characterized by comprising the following steps:

9. The method according to claim 8, wherein in step S1, after the patient places the wrist on the forearm support of the pulse diagnosis platform, the position adjustment controller controls the camera of the automatic locator of the pulse condition instrument to take a picture of the wrist, and the position adjustment controller identifies the picture of the wrist and then positions the position of the wrist, the pulse closing position and the pulse measuring position, and accordingly controls the triaxial platform to drive the three pulse condition sensors to automatically move to the position of the wrist, the pulse closing position and the pulse measuring position; after the flexible transparent pulse touch film of the pulse condition sensor touches the skin, the pressure in the watertight compartment can be changed, the hydraulic sensor transmits the pressure data measured in real time to the central controller, the central controller transmits the pressure data to the computer system, and the positioning is completed after the fluctuation of the pressure of the watertight compartment is detected.

10. The method according to claim 8, wherein in step S2, the specific process of the up-down movement control mechanism driving the up-down movement of the three pulse-taking sensors respectively is as follows: