CN108338789A - A kind of intelligent capsule - Google Patents
A kind of intelligent capsule Download PDFInfo
- Publication number
- CN108338789A CN108338789A CN201810316600.7A CN201810316600A CN108338789A CN 108338789 A CN108338789 A CN 108338789A CN 201810316600 A CN201810316600 A CN 201810316600A CN 108338789 A CN108338789 A CN 108338789A
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- China
- Prior art keywords
- capsule
- helical antenna
- sensor
- intelligent
- acid
- Prior art date
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- 239000002775 capsule Substances 0.000 title claims abstract description 101
- 239000003814 drug Substances 0.000 claims abstract description 83
- 229940079593 drug Drugs 0.000 claims abstract description 51
- 238000012545 processing Methods 0.000 claims abstract description 14
- 238000010897 surface acoustic wave method Methods 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000002195 soluble material Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 abstract description 4
- 238000012544 monitoring process Methods 0.000 abstract description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 239000006187 pill Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 6
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 6
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 241000167880 Hirundinidae Species 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000003340 mental effect Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000017667 Chronic Disease Diseases 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WGWACCCAJWZIML-UHFFFAOYSA-N benzene;buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N.C1=CC=CC=C1 WGWACCCAJWZIML-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000004146 energy storage Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000010112 shell-mould casting Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6861—Capsules, e.g. for swallowing or implanting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6871—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Abstract
The present invention relates to intelligent medical field more particularly to a kind of intelligent capsules.Intelligent capsule includes：Capsule shell, capsule shell side are arranged an acid-soluble lid, include in capsule shell：The side of medicine holding bin, medicine holding bin is acid-soluble lid, and piston is arranged in the other side, and a confined space is collectively formed for storing powdered or liquid drug in medicine holding bin, acid-soluble lid and piston；Piston connects helical antenna backwards to the side of medicine holding bin, and helical antenna has a target operating frequency；The side that processing chip is not connected with piston with helical antenna is connect；Sensor is fixed on the inner wall of capsule shell, and processing chip connects on a sensor backwards to the one side of helical antenna；Sensor is also communicated by helical antenna with external read device.The present invention is based on surface acoustic wave sensor technologies, increase the reliability of intelligent capsule wireless inquiry, and external environment condition parameter is combined to measure, are conducive to the stability monitoring to Patient drug's compliance, while reducing drug cost.
Description
Technical field
The present invention relates to intelligent medical field more particularly to a kind of intelligent capsules.
Background technology
Due to many chronic diseases (such as schizophrenia) patient in terms of behavior is normative and behavior pattern forms ability all
There are larger defect, this simple expert along training Feasible degree often compares shortcoming.To ensure that sufferer can be in accordance with doctor's advice on time
It takes medicine according to quantity, some medications supervision product comes into being.
Intelligent medicine box is the pioneer product in intelligent medical field.But also largely there is limitation in intelligent medicine box.
For example, intelligent medicine box can only judge whether drug is removed medicine box and cannot judge whether patient has taken drug.For spirit
Divide patient, be originated from that side effects of pharmaceutical drugs bring to a certain extent to the non-compliance of drug to the conflict of drug or right
In the fear injured from relatives and healthcare givers.They be required medication when, it is possible to by drug ensconce with without
It takes.In this case, intelligent medicine box is difficult to judge whether patient takes medicine, to delay therapeutic process, the disease of making patients
Feelings.
In this context, " smart pill " this emerging concept occurs.Smart pill can be by tablet in different rings
The difference shown under border is monitored the location of drug.Such as relatively Proteus companies of the U.S. production of mainstream at present
Smart pill its built-in chip is triggered using hydrochloric acid in gastric juice, to carry out the transmission of signal.The appearance of smart pill is very big
Ground improves the defect that intelligent medicine box False Rate is high, supervision property is poor, is provided the real-time oversight of sufferer medication situation for doctor
It is convenient, it realizes " precisely medical treatment ".
But by analyzing current existing solution, almost all of smart pill is required for built-in power
It is powered and cost is higher.Since the market orientation of smart pill is often to be taken daily for the vast sufferer tormented by chronic disease
With, and cost increase caused by complicated structure is likely to be unfavorable for popularization of the smart pill in these sufferers, violates
The principle of " general favour medical treatment ".In addition, the intervention of power supply also can bring certain shadow to the reliability of smart pill with service life
It rings, is unfavorable for the stability monitoring to Patient drug's compliance.
Invention content
The object of the present invention is to provide a kind of intelligent capsules, are based on surface acoustic wave sensor technology, are not necessarily to power supply power supply, tool
There is the antenna structure just discharged under gastric acid environment, increases the reliability of intelligent capsule wireless inquiry.In conjunction with external environment condition parameter
It measures, is conducive to the stability monitoring to Patient drug's compliance, while making drug cost reduction.
Technical scheme of the present invention：
A kind of intelligent capsule, wherein：The intelligent capsule includes：
Capsule shell, the capsule shell side are arranged an acid-soluble lid, include in the capsule shell：
The side of medicine holding bin, the medicine holding bin is the acid-soluble lid, and a piston, the medicine holding bin, institute is arranged in the other side
State acid-soluble lid and a confined space be collectively formed in the piston, in the confined space for storing powdered or liquid
The drug of shape；
The piston connects a helical antenna backwards to the side of the medicine holding bin, and the helical antenna has a preset mesh
Mark working frequency；
Processing chip, the side that the piston is not connected with the helical antenna are connect；
Sensor is fixed on the inner wall of the capsule shell, one side of the processing chip backwards to the helical antenna
It is connected on the sensor；The sensor is also communicated by the helical antenna with the reader outside one, described
Reader is used to receive the sensor information of the sensor output；
When being full of the drug in the medicine holding bin, the helical antenna is compressed, the current work of the helical antenna
Working frequency deviates the target operating frequency, and the reader can not receive the sensor letter of the sensor output
Breath；
The opening formed after the drug in the medicine holding bin is dissolved by the acid-soluble lid is all released
Afterwards, the helical antenna restores original length, and the current working frequency of the helical antenna is equal to the target operating frequency, institute
State the sensor information that reader receives the sensor output.
Preferably, above-mentioned intelligent capsule, wherein：The helical antenna is bonded with the inner wall of the capsule shell.
Preferably, above-mentioned intelligent capsule, wherein：The sensor is surface acoustic wave sensor.
Preferably, above-mentioned intelligent capsule, wherein：The acid-soluble lid is less than for the diameter of cylinder and the acid-soluble lid
The diameter of the capsule shell, the acid-soluble lid are set to the surface of the capsule shell and close the table of the capsule shell
The opening of face setting.
Preferably, above-mentioned intelligent capsule, wherein：The acid-soluble lid is made of acid-soluble material.
Preferably, intelligent capsule a, which is characterized in that temperature sensor is also set up in the processing chip, for examining
Survey the real time temperature inside the intelligent capsule；
The sensor information includes the real time temperature.
Preferably, intelligent capsule, which is characterized in that the sensor information includes the number letter of the intelligent capsule
Breath.
Preferably, intelligent capsule, which is characterized in that there is each intelligent capsule the number of unique mark to believe
Breath.
Beneficial effects of the present invention：
A kind of intelligent capsule is provided, surface acoustic wave sensor technology is based on, is not necessarily to power supply power supply, is had in gastric acid environment
The antenna structure of lower just release, increases the reliability of intelligent capsule wireless inquiry, and external environment condition parameter is combined to measure, favorably
In the stability monitoring to Patient drug's compliance, while reducing drug cost.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of intelligent capsule of the present invention；
Fig. 2 is a kind of capsule shell structural schematic diagram of intelligent capsule of the present invention；
Fig. 3 is a kind of piston structure figure of intelligent capsule of the present invention；
Fig. 4 is a kind of wireless wave working sensor flow diagram of intelligent capsule of the present invention.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art obtained under the premise of not making creative work it is all its
His embodiment, shall fall within the protection scope of the present invention.
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
The invention will be further described in the following with reference to the drawings and specific embodiments, but not as limiting to the invention.
As shown in Figure 1, the present invention provides a kind of intelligent capsules to include：
Capsule shell 1 is cylindrical structure, and length is not more than 35mm, and diameter is not more than 15mm, in designed enclosures structure,
It should ensure that its round and smooth degree and good surface treatment.Often in 1-2 after auxiliary drug release class product enters digestion
It is discharged after it, will not cause damages substantially to the digestive system of people.But if 1 structure of capsule shell is not smooth enough, and it will be to patient's
Swallow comfort level, enterogastric peristalsis impacts.Therefore when selection 1 material of capsule shell, it should ensure that it has ideal bio-compatible
Property.Since acrylonitrile-butadiene-styrene copolymer (ABS) under -25-60 DEG C of temperature environments with chemical characteristic stablize by machinery,
And processing finished surface is smooth, it can opposed capsule inner wall easy slide.In addition the excellent case hardness of ABS material and shock resistance are strong
Degree is to ensure that serious deformation does not occur for piston 4 during piston 4 is pushed to capsule bottom.Meanwhile ABS is nontoxic, corrosion resistant steady
Determine the ideal chose that chemical property has also become sheathing material.Shell is quasi- in the present invention selects acrylonitrile-butadiene-benzene second
Alkene copolymer is as making material.Acrylonitrile-butadiene-styrene copolymer is that one kind having high intensity, high tenacity, high thermoplastic
The high molecular material of property, density is close with water phase, about 1.04-1.06g/cm3, meets the light-weight requirements of capsule shell 1.
Acid-soluble lid 3 is arranged in 1 side of lid capsule shell.To there is smaller discomfort when patient being made to swallow with enterogastric peristalsis
Sense selects to select length 26mm, diameter 11mm, thickness 0.5mm when shell moulding in of the invention, the upper bottom surface fillet of falling 10mm
Streamlined cylindrical shell；Acid-soluble lid 3 is glued with 1 one bottom surface of capsule shell, is diameter 8mm, and thickness is the cylinder of 0.5mm.It is right
In acid-soluble lid 3, intends this common gastric solubility material using hydroxypropyl methyl cellulose (HPMC) and make so that intelligent capsule
It is quickly dissolved into after in the stomach of patient by hydrochloric acid in gastric juice, to which drug release comes out.1 structure of capsule shell is as shown in Figure 2.
Include in capsule shell 1：
Medicine holding bin 2 is used for holding medicine, and the side of the medicine holding bin 2 is the acid-soluble lid 3, and other side setting one is lived
Plug 4.A confined space is collectively formed in medicine holding bin 2, acid-soluble lid 3 and piston 4, in confined space for store it is powdered or
The drug of person's liquid.As shown in figure 3, piston 4 is cylindrical structure and diameter is identical as the inner diameter of capsule shell.Piston 4
Also it is making material that acrylonitrile-butadiene-styrene copolymer, which should be selected,.According to the size of capsule shell 1, piston 4 selects
Radius is 5.0mm, and thickness is the cylinder of 1.7mm, and it is 0.5mm that the portion being connect with helical antenna 5, which separates radius, and depth is
The mortise of 1.5mm.Piston 4 connects a helical antenna 5 backwards to the side of medicine holding bin 2.
Since intelligent capsule is essentially a passive measurement system, the quality factor, impedance match situation of sensor itself
Gain with helical antenna 5 can impact the distance of reaction of sensor 6, to influence the working performance of capsule.So
Type and specification to helical antenna 5 have higher requirement.Normal helical antenna not only have excellent radianting capacity with compared with
Considerable gain, and since its shape and capsule shell 1 goodness of fit are high and be easy to change it by the modes such as compressing or stretching
Shape can be used as the antenna model selection of the design to change reception.Normal helical antenna 5 has effector and refers to simultaneously
The dual function for showing device eliminates additional indicating unit and compliance mechanism for identifying, saves drug storage space and cost of manufacture.
In the present invention, consider sensor 6, processing chip 7, helical antenna 5, piston 4 synthesis assembling scheme, propose meter day
The spiral part length of line is L=23mm, and feeding line portion length is 1.8mm, and antenna uses the shape memory of line footpath d=1.0mm
Alloy material coiling.And it is the convenience for ensureing antenna and capsule assembly, design antenna spiral outer diameter is D=9.8mm.Through meter
It calculates, under the working frequency that 433MHz can be obtained, antenna the number of turns N is about 8.3 circles.I.e. helical antenna 5 has a preset target work
Working frequency, target operating frequency 433MHz.
The side that processing chip 7 is not connected with piston 4 with helical antenna 5 is connect.Processing chip 7 can be pasted and is formed in the present invention
On one printed circuit board, it can also be made of one piece of individual chip.
Sensor 6, be fixed on the inner wall of the capsule shell 1 and connect with processing chip 7 and sensor 6 be passive biography
Sensor.There is surface acoustic wave (Surface Acoustic Wave abbreviation SAW) sensor longer service life to resist with ideal
Interference performance can be used as the ideal chose of intelligent capsule sensing system.It is deposited again relative to delayer energy due to SAW resonator
Energy storage power is stronger, and telemeasurement ability is more excellent, therefore selective resonance type SAW temperature sensor is as the built-in sensing of capsule
Device.SAW wireless sensor systems are made of reader and SAW sensor two parts.
For passive saw sensor module, the pulse based on time domain can be divided into according to the difference of measurement method and looked into
Inquiry method and the frequency sweep method based on frequency domain.Although frequency domain method can get farther measurement distance, it is easy to obscure with frequency
The transmitting of section and reception signal, influence the dynamic characteristic of echo-signal.Time domain approach utilizes reader transmitting and resonator resonance
Pulse signal similar in frequency carries out frequency search to Whole frequency band, according to the different echoing characteristics estimated resonant of different frequency component
The resonant frequency of device saves the frequency search time of frequency sweeping method.The design it is quasi- using the pulse query method based on time domain into
Row measures.
It is illustrated in figure 4 the wireless measurement workflow based on SAW：Reader sends Persistent Excitation to resonator first
The energy of short pulse, resonator will reach stable state gradually, at this time reader terminate pulse send and by duplexed antenna reception come
The free damping echo-signal of resonator, and Frequency Estimation is carried out to echo-signal eventually by query unit and measures resonator
Resonant frequency.
Sensor is also communicated by helical antenna with the reader outside one, and reader is believed for receiving sensor 6
Breath, staff may determine that whether drug is entered patient's body by checking reader.
When drug is not swallowed, helical antenna 5 is in compressive state, and 2 holding medicine of medicine storehouse is constituted in capsule.Intelligence
After capsule enters in human stomach, due to the corrosion of hydrochloric acid in gastric juice, lid made of acid-soluble material will gradually melt, when powdered or liquid
Drug discharges in alimentary canal terminate after, will restore former long since antenna 5 loses constraint, and push piston 4 so that capsule weight
Novel sealing.
The workflow of intelligent capsule can be reduced to drug storage standby phase, drug release stage and internal phase of sensitization three parts.
In drug storage standby phase, since helical antenna 5 is compressed at this time, working frequency will deviate from target operating frequency
(it is assumed herein that being commercial communication frequency 433MHz), reader can not inquire 6 information of sensor of capsule.
After sufferer takes intelligent capsule, capsule will enter via oesophagus in stomach.Since capsule has an acid close to 2 one end of medicine storehouse
Dissolubility lid 3 will gradually dissolve in stomach under the action of hydrochloric acid in gastric juice.After acid-soluble lid 3 dissolves, drug will contact gastric juice simultaneously
Start to discharge, simultaneously because the constraint of helical antenna 5 weakens, helical antenna 5 will start to restore deformation.After drug release,
Helical antenna 5 will restore former long, and piston 4 is pushed to capsule bottom.
At this point, 5 working frequency of helical antenna return in normal working frequency (such as 443MHz or other preset
Working frequency), sensor information can be inquired using sensor reader, to judge that capsule is disappeared via stomach is dirty
Change.Healthcare inquires the sensor in patient by reader can be according to the presence or absence of echo-signal to suffering from
On time whether medication judges person according to quantity.
Some can not be felt using the intelligent capsule in the present invention and swallow or be reluctant to feel the disease for swallowing drug
Trouble is monitored, to ensure that these sufferers can swallow drug on time, it is ensured that therapeutic effect.
By taking mental patient as an example, a degree of resistance may be generated to swallowing drug, to which refusal swallows medicine
Object is either pretended to swallow drug and drug is hidden or abandoned actually, to ensure the effect of psychiatric treatment.Using upper
The case where mental patient swallows drug can be monitored well by stating intelligent capsule.Specifically, after mental patient takes medicine,
It may be used in the present invention and attempting to receive sensing close to the position of mental patient's belly with the matched reader of intelligent capsule
Device information.Due to the drug that the intelligent capsule only includes wherein be completely released and antenna restore to original it is long after just can be outside
Transmission sensor information, therefore only after sufferer swallows drug and fully absorbs drug, reader can receive biography
Sensor information, this makes it possible to find the case where sufferer be unwilling to swallow drug in time and corrected in time, to ensure to treat
Effect.
Further, may include the number information (ID) of intelligent capsule in the sensor information, reader is by connecing
The ID number of intelligent capsule is received to judge whether the intelligent capsule is swallowed by sufferer.
Further, the number information of different intelligent capsules is different, i.e., each intelligent capsule has unique
The number information of mark.Reader judges that sufferer has once swallowed several medicines by the quantity of the number information received, with
It is compared afterwards with scheduled therapeutic scheme, to judge whether sufferer swallows drug in strict accordance with therapeutic scheme.
Further, the temperature information of intelligent capsule current internal can also be included in the sensor information.Specifically
Ground, an also integrated temperature sensor (not shown), real-time inside intelligent capsule for detecting in above-mentioned processing chip 7
Temperature, and current real time temperature is included in sensor information.
Then after reader receives sensor information, so that it may obtain real time temperature wherein included with parsing.Due to disease
Suffer from internal temperature and be generally stabilized at 37 DEG C or so, and can be by measuring the modes dynamic control such as body temperature in advance, this and room
Outer temperature is different, therefore same in such a way that reader receives real time temperature and judges whether to be consistent with the body temperature of sufferer
Sample may determine that whether sufferer has swallowed drug.
The foregoing is merely preferred embodiments of the present invention, are not intended to limit embodiments of the present invention and protection model
It encloses, to those skilled in the art, should can appreciate that all with made by description of the invention and diagramatic content
Equivalent replacement and obviously change obtained scheme, should all be included within the scope of the present invention.
Claims (8)
1. a kind of intelligent capsule, it is characterised in that：The intelligent capsule includes：
Capsule shell, the capsule shell side are arranged an acid-soluble lid, include in the capsule shell：
The side of medicine holding bin, the medicine holding bin is the acid-soluble lid, and a piston, the medicine holding bin, the acid is arranged in the other side
A confined space is collectively formed in dissolubility lid and the piston, in powdered or liquid for storing in the confined space
Drug；
The piston connects a helical antenna backwards to the side of the medicine holding bin, and the helical antenna has a preset target work
Working frequency；
Processing chip, the side that the piston is not connected with the helical antenna are connect；
Sensor is fixed on the inner wall of the capsule shell, and the processing chip is connected backwards to the one side of the helical antenna
On the sensor；The sensor is also communicated by the helical antenna with the reader outside one, the reading
Device is used to receive the sensor information of the sensor output；
When being full of the drug in the medicine holding bin, the helical antenna is compressed, the current work frequency of the helical antenna
Rate deviates the target operating frequency, and the reader can not receive the sensor information of the sensor output；
After the opening formed after the drug in the medicine holding bin is dissolved by the acid-soluble lid is all released, institute
It states helical antenna and restores original length, the current working frequency of the helical antenna is equal to the target operating frequency, described to read
Read the sensor information that device receives the sensor output.
2. intelligent capsule according to claim 1, it is characterised in that：The inner wall of the helical antenna and the capsule shell
Fitting.
3. intelligent capsule according to claim 1, it is characterised in that：The sensor is surface acoustic wave sensor.
4. intelligent capsule according to claim 1, it is characterised in that：The acid-soluble lid is cylinder and described acid-soluble
The diameter of lid is less than the diameter of the capsule shell, and the acid-soluble lid is set to described in surface and the closing of the capsule shell
The opening of the surface setting of capsule shell.
5. intelligent capsule according to claim 4, it is characterised in that：The acid-soluble lid is made of acid-soluble material.
6. intelligent capsule according to claim 1, which is characterized in that also set up a temperature sensing in the processing chip
Device, for detecting the real time temperature inside the intelligent capsule；
The sensor information includes the real time temperature.
7. intelligent capsule according to claim 1, which is characterized in that the sensor information includes the intelligent capsule
Number information.
8. intelligent capsule according to claim 7, which is characterized in that each intelligent capsule has the institute of unique mark
State number information.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316600.7A CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810316600.7A CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108338789A true CN108338789A (en) | 2018-07-31 |
| CN108338789B CN108338789B (en) | 2023-12-19 |
Family
ID=62957357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810316600.7A Active CN108338789B (en) | 2018-04-10 | 2018-04-10 | Intelligent capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108338789B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113690574A (en) * | 2021-08-16 | 2021-11-23 | 维沃移动通信有限公司 | Antenna assembly, electronic equipment and control method of antenna assembly |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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