CN108309559A - Induced retinal generates and discharges dopamine and activate the method and ophtalmic treatments instrument of dopamine receptor D1 - Google Patents
Induced retinal generates and discharges dopamine and activate the method and ophtalmic treatments instrument of dopamine receptor D1 Download PDFInfo
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- CN108309559A CN108309559A CN201810110240.5A CN201810110240A CN108309559A CN 108309559 A CN108309559 A CN 108309559A CN 201810110240 A CN201810110240 A CN 201810110240A CN 108309559 A CN108309559 A CN 108309559A
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 229960003638 dopamine Drugs 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000002207 retinal effect Effects 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title claims abstract description 20
- 102100020802 D(1A) dopamine receptor Human genes 0.000 title claims abstract description 11
- 101000931925 Homo sapiens D(1A) dopamine receptor Proteins 0.000 title claims abstract description 11
- 210000001525 retina Anatomy 0.000 claims abstract description 41
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000007246 mechanism Effects 0.000 claims description 17
- 210000005252 bulbus oculi Anatomy 0.000 claims description 16
- 210000003128 head Anatomy 0.000 claims description 16
- 238000004891 communication Methods 0.000 claims description 14
- 230000003287 optical effect Effects 0.000 claims description 7
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 239000004973 liquid crystal related substance Substances 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 4
- 238000002560 therapeutic procedure Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 2
- 208000001491 myopia Diseases 0.000 abstract description 16
- 201000009487 Amblyopia Diseases 0.000 abstract description 13
- 230000004379 myopia Effects 0.000 abstract description 12
- 230000001225 therapeutic effect Effects 0.000 abstract description 6
- 238000011161 development Methods 0.000 abstract description 4
- 210000000695 crystalline len Anatomy 0.000 description 20
- 239000004065 semiconductor Substances 0.000 description 9
- 210000001508 eye Anatomy 0.000 description 8
- 239000002184 metal Substances 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
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- 102000005962 receptors Human genes 0.000 description 4
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- 241001270131 Agaricus moelleri Species 0.000 description 2
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- 239000011159 matrix material Substances 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
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- 101150049660 DRD2 gene Proteins 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
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- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00863—Retina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
Abstract
The present invention provides a kind of method that induced retinal generates and discharges dopamine and activate dopamine receptor D1, the wavelength of the light of retina is irradiated in by control, be irradiated in the power of retina light, be irradiated in retina light time break and control be irradiated in retina light area of space method with achieve the purpose that the cell on induced retinal generate and release dopamine with inhibit myopia and amblyopia development reach therapeutic purposes.And a kind of instrument for treating myopia and amblyopia is provided, pedestal, control unit and Internet of Things net unit are included at least, to realize treatment of the remote control to myopia and amblyopia.
Description
Technical field
It is generated with induced retinal the present invention relates to a kind of utilization light irradiation eyeball and discharges dopamine and activate DOPA
The method of amine receptor D1 is to inhibit myopia and amblyopia to develop, and one kind according to above method research and development is used to treat myopia or weak
Depending on ophthalmic medical instrument.
Background technology
The incidence of teen-age myopia is very high in China, according to 15 years old teen-age near-sighted incidence of investigation China
It is 78.5%.Some researches show that improve dopamine (DA) in the yield of retina to slowing down and inhibiting eyes to near-sighted direction
Development can play important influence.
Dopamine is a kind of neurotransmitter, for helping the chemical substance of cell transfer pulse.Mass data can be with
For supporting that dopamine is one of the retinal neurotransmitter for participating in signal cascade.There is dopamine receptor D1- on the retina
D5.Dopamine will control hair of the dioptric development of eyeball structure as controlled Scleral structures by the activation of dopamine receptor mediates
It educates and adjusts eyeball axial growth and develop to near-sighted direction or develop to long sight direction.
Applicant is by for a long time to illumination with the research of myopia progression relationship and to the science tracking in ophthalmic medical field
It was found that retinal dopamine level can be improved in luminous intensity increase, mechanism is that illumination gives light type access by retina so that
Amakrine generates and discharges dopamine on retina.It is found in the experimental study to cavy, strong light group and dim light group
In contrast experiment, the DOPAMINE CONTENT IN RABBIT of the Guinea Pig Retina of strong light group obviously rises and the eyeball diopter that axially shortens obviously more becomes
In long sight.But there is no the content for further promoting dopamine, diopters to be also further change in for the strong illumination of duration.This
Illustrate that generation and the release of dopamine are not merely only related with intensity of illumination.
It is spy to find light stimulation retina according to the research of applicant in recent years to inhibit the mechanism of myopia progression trend
The illumination of standing wave length is irradiated in more to the release of light type Beale's ganglion cells glutamate release material incentive amakrine on retina
Bar amine.And the dopamine released will act on the dopamine D 1 being distributed widely on retina and D2 receptors, and distribution
Dopamine D 2 in retinal pigment epithelium (RPE) and D4 receptors.Dopamine can make after acting on above-mentioned receptor
Corneal curvature flattens, front is deeper, crystalline lens is thinner, sclerotic cartilage cell Proliferation, and the above exercising result can make axis oculi to remote
Light direction development inhibits myopia.Based on the above mechanism, it is found by the applicant that it is irradiated in the wavelength of retina glazed thread, light power,
The break time of irradiation and the area of space that is irradiated on retina etc., factors were rather than just one combined factors of light intensity
Can influence dopamine generation and release and to eyes myopia inhibition.
The eye diseases therapy for irradiating retina using light to treat myopia and amblyopia and design is existing for many years.Such as public affairs
The number of opening is CN107260504A, and a kind of entitled treat discloses using light source in amblyopia and/or near-sighted instrument by eyepiece
Project equipment of the light irradiation eyes to treat myopia or amblyopia.But eye is irradiated just with light source, not according to upper
The generating means of principle design specific wavelength is stated, the device of power, the dress of design interval irradiation are replaced in design different wave length irradiation
It sets, designs the control device of light intensity and control is irradiated in the control device in region on retina.
Invention content
In order to solve the above technical problems, dopamine is generated and discharged the present invention provides a kind of induced retinal and is activated more
The method of bar amine receptor D1, the purpose is to be generated by induced retinal and discharge dopamine and activate dopamine receptor D1, with
The development of myopia either amblyopia is inhibited further to provide a kind of ophthalmic medical instrument for treating myopia or amblyopia.
A kind of method that induced retinal generates and discharges dopamine and activate dopamine receptor D1, which is characterized in that its
By control be irradiated in retina light wavelength, be irradiated in the power of retina light, be irradiated in retina light when
Between be interrupted and control be irradiated in retina light area of space method with reach the cell on induced retinal generate and
The purpose for discharging dopamine, specifically includes,
Step 1 discharges the light irradiation eyeball of certain wavelength；
Step 2, interrupted illuminating；
Step 3 repeats step 1 and step 2.
A kind of method that induced retinal generates and discharges dopamine and activate dopamine receptor D1, is irradiated by controlling
In the wavelength of the light of retina, it is irradiated in the power of retina light, is irradiated in the time break and control of retina light
System is irradiated in the method for the area of space of retina light and generates and discharge dopamine to reach the cell on induced retinal
Purpose specifically includes,
Step 1 discharges the light irradiation eyeball of certain wavelength；
Step 2, the light for discharging another certain wavelength irradiate eyeball；
Step 3, interrupted illuminating；
Step 4 repeats step 1 to three.
The light of two kinds of specific wavelengths can carry out alternately irradiating eyeball, such photograph according to the radiation modality of certain power
Penetrate the generation of mode induction dopamine more better than the light of the single light intensity of use and wavelength irradiation eyeball.And in above-mentioned step
There are one the break time irradiated without light in rapid, retina it will can fully adjust in the break time and be conducive to generate
With release dopamine.
Preferably, the range of light wavelengths are 650-680nm.
A kind of ophtalmic treatments instrument is tied it can be used to inhibit the development of myopia and amblyopia, help to restore twenty-twenty vision
Structure includes
Pedestal, the support portion as entire instrument；
Control unit is used to control the operation of entire instrument, including signal input unit and information feedback unit, control
Unit processed includes that control circuit and the component that can operate for the treatment of personage are used to control entire instrument；
Light source treatment unit, including eyepiece and the light source generation that is set to after eyepiece, eyepiece be to light into
The structure of line focusing at least will include the lens subassembly of lens barrel and setting in the inner, and light source generation is can to emit light
The structure of beam, such as laser diode and LED light lamp；
And Internet of Things net unit, it can be connect with host computer, realize wireless communication, i.e., by far from upper where instrument
The realization control at a distance of interconnecting of position machine, such as starts instrument, feedback treating data, analysis data etc..
Further, the control circuit of power interface and control unit is provided in the pedestal；
The control unit includes touch liquid crystal display curtain, can be inputted to instrument by the LCD screen and instruct and lead to
Cross the LCD screen feedback data information；
The Internet of Things net unit, including an information collection port and a wired or wireless data communication unit
Member, it is upper by being write to each other by communication unit and host computer realization after the information collection port processing data information
Machine carries out the comparison of data information, realizes the operation of remote control equipment.
Further, it is provided with support base on the pedestal, the rotating arm of the support base and head is connected to one
Body adjusts the rotating disk being set on the outside of rotating arm on two sides to drive the head to do the adjusting of pitch angle.Different
The difference of its height build for the treatment of personage needs to adjust the position of account head, so that its pair of the eyepiece face being set in head
Eye so that eyeshade can fit in the eye socket of people with or excellent mass effect.Can also it be illustrated by its setting, light
The incident angle for being irradiated in the eyeball of people is also a factor for influencing therapeutic effect.
The head section includes hood, the eyepiece being set in hood and the light source base for being set to eyepiece rear,
It is provided with laser generator in the light source base；
Uniform intensity generator is provided in the eyepiece；
It further include the interpupillary adjustment mechanism for adjusting distance between eyepiece.
Preferential, the laser generator includes accommodating cavity, and the accommodating inside cavity is provided with spectroscope, institute
Be provided on the side wall for the accommodating cavity stated for light by access；
One end of the accommodating cavity is provided with laser diode, and the other end is provided with lens；
The rear end of the accommodating cavity is provided with circuit board；
And photodetector its connect the light that can receive to be projected by access with circuit board, and to circuit board feedback letter
Number.
It is capable of the power of Real-time Feedback light intensity by the way that photodetector unit is arranged, and voltage and current is adjusted by control unit
To control laser diode light intensity, injury of the excessively high light intensity to eyes is prevented.Light is split by spectroscopical, is made
It obtains the light occurred by laser diode no more than 5% and is irradiated in the photoelectricity spy by the way that the through-hole in metal sleeve is arranged
It surveys on device, realizes the examinations to light intensity.The laser diode is connect with control circuit simultaneously, the control circuit
Current Voltage can be adjusted and control light intensity, while the photodetector, energy to control the luminous power of laser diode
Feedback electric signal realizes automatic control and adjustment to control circuit after enough light intensity by perception.
Further, the uniform intensity generator includes,
Transparent components,
Diffraction optical element,
And lens；
Wherein, the transparent components are made of a pair of of angle of wedge prism, and the angle of wedge prism includes prism one and prism
Two, the right-angle plane of the prism one is arranged in opposite directions with the angle of wedge plane of prism two so that incident beam is through prism one and rib
Light beam is become round by oval-shaped beam after the refraction of mirror two.
The uniform intensity generator can be arranged such that laser beam by oblong light by a pair of of prism wedge
Shape of spot variation becomes circular light spot shape to prevent energy from concentrating the injury to retina.To realize that control is irradiated in view
It is equal to be converted to flat-top by the area of space of film light by diffraction optical element by Gaussian Profile for the Energy distribution form of laser beam
So that the energy being irradiated on retina is uniform, setting plano-concave lens expands into the region area of eyeball for even distribution.By upper
State the effect of uniform intensity generator so that the light energy uniform irradiation area being irradiated on retina is big, effectively prevent swashing
Beam energy concentrates the injury to retina, and can realize that the energy stepless action of irradiation area area significantly improves treatment effect
Fruit.
Preferably, the interpupillary adjustment mechanism includes two frame bodies, and being provided on one of described frame body can
The hold assembly of object is clamped, the side of another frame body is provided with gear regulating mechanism；The gear adjusts machine
Structure includes at least,
Cantilever frame body,
Gear, and
Adjusting handle, and the gear is engaged realization gear drive with adjusting handle；
The adjusting handle can be rotated around itself and cantilever frame body junction.
Gear regulating mechanism so that the close of lens barrel or separation are realized in the movement that arc can be done between lens barrel, in turn
The people for adjusting different interpupillary distances enters the light path of eyes to realize best therapeutic effect using adjusting when same equipment.
A method of using above-mentioned ophthalmic medical instrument, which is characterized in that
Microchip carrier containing data information is positioned on the information collection port by step 1, which adopts
The data information in microchip will be read by collecting port, and be write to each other by communication unit and host computer realization, and data are uploaded
Data comparison is carried out to host computer；
Step 2, host computer will feed back control circuit of the data information to control unit after acquiring information, control
Circuit will decide whether to start instrument according to the data information of feedback；
Step 3, if starting instrument, then the control circuit of control unit can read the related data information in microchip,
And action is executed according to logic step, and by relevant marker information feedback on LCD screen；
Step 4, user complete therapeutic process；
Data information after treatment is connect by communication unit with host computer and updates the data information by step 5, instrument.
The method that a kind of induced retinal provided by the invention generates and discharges dopamine and activate dopamine receptor D1,
Advantageous effect is：It is irradiated in the wavelength of the light of retina by control, is irradiated in the power of retina light, is irradiated in and regards
The time break and control of nethike embrane light are irradiated in the method for the area of space of retina light to reach on induced retinal
Cell generate and release dopamine purpose with inhibit myopia and amblyopia development reach therapeutic purposes.And provide a kind of treat closely
It is reasonable for structure and can effectively reach therapeutic purposes depending on the instrument with amblyopia.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described.
Attached drawing 1 is a kind of operational flowchart of ophthalmic medical instrument in the present invention；
Attached drawing 2 is a kind of stereogram of ophthalmic medical instrument in the present invention；
Attached drawing 3 is the front view of attached drawing 2；
Attached drawing 4 is the structural schematic diagram of the lens barrel of eyepiece, interpupillary adjustment mechanism and light source base in head shell；
Attached drawing 5 is the vertical view of Fig. 4；
Attached drawing 6 is the front view of Fig. 4；
Attached drawing 7 is the structural schematic diagram of the semiconductor laser diode in light source base；
Attached drawing 8 is the electrical schematic diagram of semiconductor laser diode；
Attached drawing 9 is the structural schematic diagram of uniform intensity generator in the lens barrel of eyepiece；
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes.
A kind of ophthalmic medical instrument, stereogram is as shown in Fig. 2, it can be used to inhibit the development of myopia and amblyopia, side
The recovery twenty-twenty vision, structure is helped to include
Pedestal 1, the support portion as entire instrument；
Control unit is used to control the operation of entire instrument, including signal input unit and information feedback unit, control
Unit processed includes that control circuit and the component that can operate for the treatment of personage are used to control entire instrument, can be seen in Fig. 1
To 2 part of liquid crystal display of control unit, and control circuit part is then distributed in the inside of pedestal 1 and the shell of Medical Instruments
Portion.By means of liquid crystal display 2, the input data information into control circuit, the most of the time will show input on liquid crystal display 2
Button also or be modular data information, to facilitate treatment personnel to use.
Light source treatment unit comprising eyepiece and the light source generation being set to after eyepiece.The eyepiece and
Light source generation after eyepiece may be contained in the shell of head 3 of Fig. 1.The front of head 3 is provided with 31 part of eyeshade,
31 part of eyeshade is bonded with the eye socket part of people, has the light for the 650-680nm wavelength that light source generation emitted will
It can be irradiated in the ball portions induced retinal generation of people after the focusing of eyepiece and discharge dopamine and activate dopamine
Receptor D1.
Support base 12 is provided on the pedestal 1, the rotating arm 32 of the support base 12 and head 3 is connected to one
Body adjusts the rotating disk 33 being set on 32 outside two sides of rotating arm to drive the head 3 to do the adjusting of pitch angle.No
With the difference for the treatment of personage its height build need the position of tune account head so that the eyepiece face being set in head its
Eyes so that eyeshade can fit in the eye socket of people with or excellent mass effect.Can also it be illustrated by its setting, light
The eyeball for being irradiated in people incident angle be also influence therapeutic effect a factor.
Eyepiece part in 3 shell of head, for adjusting the interpupillary adjustment mechanism of distance between eyepiece and being arranged in mesh
Light source seating portion after mirror is as shown in Figure 4.Specifically interpupillary adjustment mechanism is used to adjust the regulating mechanism of distance between eyepiece
Part is used to adjust the distance between lens barrel 4 of eyepiece, including frame body 51,52 is divided into the both ends of lens barrel 4.The frame body 51
Side be provided with gear regulating mechanism 6, the gear regulating mechanism 6 has included at least frame body 61, gear 62,63, and
Adjusting handle 64,65.The frame body 61 is a kind of cantilever frame body being set between lens barrel 4, is for installing adjusting hand
The purpose of wheel 64,65 and gear 62,63, and make between the gear 62,63 can engaged transmission, the adjusting handle
64,65 rotate around itself and 61 contact position of frame body.Shown in adjusting handle 64,65 be to protrude from 3 shell of head (such as Fig. 2),
Treatment personnel can realize the distance between the lens barrel 4 of eyepiece by adjusting handle 64,65.
Around it, its one kind can be that adjusting handle 64,65 is arranged to the adjusting handle 64,65 with 61 connection type of frame body
There is the end of protrusion and the frame body 61 is arranged fluted, is connected by connector between end and groove and enable end
It is enough to be rotated in groove.Another kind can be that an axis is through frame body 61 and adjusting handle 64,65 and can be pivoted.Or
Person be any those skilled in the art it is conceivable that rotatable engagement mechanical structure mode.
As shown in figure 5, the frame body 61 includes front frame body 611 and rear sheet body 612, the gear 62,63 passes through
Cylinder is set between the front frame body 611 and rear sheet body 612, and is intermeshed and is passed between the gear 62 and gear 63
Frictional force when moving, and passing through engagement realizes the self-locking of gear to position.
The structure of adjusting handle 64,65 is the integral structure of colyliform adjustment portion 641,651 and clamping part 642,652, described
Clamping part 642,652 be used to be clamped the lens barrel 4 of eyepiece, the structure of clamping part 642,652 is the component of two arcs, described
Arc part top connects with colyliform adjustment portion 641,651, and the lower part of the arc part, which can be combined into one, clasps mirror
Cylinder.
As shown in fig. 6, the hold assembly structure of 52 side of frame body is copied in clamping part 642,652, only press from both sides
Component is held to be screwed on frame body 52.The light source base of light source generation is provided with close to 52 side of frame body
7, laser light source generator is arranged inside, the light of particular range of wavelengths wavelength can be emitted, and by the lens barrel 4 of eyepiece
It projects.
Semiconductor laser light resource generator is provided in light source base 7, the semiconductor laser light resource generator architecture is such as
Shown in Fig. 7, an accommodating cavity is included at least, it is a gold in the present embodiment that structure of the accommodating cavity, which can be tubular,
Belong to sleeve 71, the metal sleeve 71 is provided at both ends with hierarchic structure as fixing component, for fixing semiconductor laser
Diode 72 and collimation lens 73.Metal sleeve 71 is internally provided with spectroscope (Beam splitter) 711, described
The laser beam emitted by the semiconductor laser diode 72 can be beamed into several beams, and portion by spectroscope 711
Divided beams (being no more than 5%) will be projected by the through-hole 74 opened up on the metal sleeve 71 outside the metal sleeve 71.
The light beam of injection will be irradiated on the photodetector 75 for being set to 71 lower section of metal sleeve.The photodetector
75, the light intensity of light beam can be perceived, and be converted into electric signal and feed back to and two pole of photodetector 75 and semiconductor laser
In the control circuit board 76 that pipe 72 electrically connects.The adjustment of electric current, voltage is made by semiconductor laser by control circuit board 76
The light intensity for the laser that diode 2 is emitted is in appropriate range.The laser beam of laser transmitter projects passes through metal sleeve 71
Afterwards using the laser beam for becoming collimation after the effect of collimation lens 73.
The electrical schematic diagram of semiconductor laser light resource generator is as shown in Figure 8
And uniform intensity generator 9 is then provided in the lens barrel 4 of eyepiece, structure is as shown in figure 9, include at least prism one
81 and prism 2 82, the prism 1 and prism 2 82 are angle of wedge prism, and the angle of wedge angle is 30 °, incident
Light is by the angle of wedge face of prism 1 through passing through the right-angle surface of prism 2 82 after superrefraction in the length for making laser beam through superrefraction
The hot spot of ellipse is turned into circular light spot.
Then laser beam is beam-splitting diffraction optics member passing through diffraction optical element 83, the diffraction optical element 83
Part comprising matrix and the optical adjustment layer being set on matrix.The diffraction optical element 83 can be by laser beam energy
Gaussian Profile morphological transformation be flat-top be uniformly distributed form so that the energy of laser beam is uniform.
Then, laser beam by by plano-concave lens 84 scattered radiation in 85 surface of eyeball, using the refraction of eyeball 85
It is irradiated on retina.
The above structure is the integrally-built narration of ophthalmic medical instrument.At least further include a set of Internet of things system, this is
System is coupled by Internet of Things in host computer so that the operation of remote control equipment and collects the treatment that treatment personnel use instrument
Data can be connect with host computer, realized wireless communication, that is, passed through the realization of interconnecting far from the host computer where instrument
Control at a distance such as starts instrument, feedback treating data, analysis data etc..
Specifically, the Internet of things system includes at least an information collection port that can read information in microchip.Such as
One card reader reads IC card.IC card is placed on the card reader by treatment personnel, it will be able to the data information in IC card is read,
And it is contacted with host computer by wired or wireless communication.Data information is compared by host computer, then feeds back to instrument again
Control unit to drive the unlatching of instrument to run or protect silent.
Method using above-mentioned ophthalmic medical instrument is as follows
Microchip carrier containing data information is positioned on the information collection port by step 1, which adopts
The data information in microchip will be read by collecting port, and be write to each other by communication unit and host computer realization, and data are uploaded
Data comparison is carried out to host computer；
Step 2, host computer will feed back control circuit of the data information to control unit after acquiring information, control
Circuit will decide whether to start instrument according to the data information of feedback；
Step 3, if starting instrument, then the control circuit of control unit can read the related data information in microchip,
And action is executed according to logic step, and by relevant marker information feedback on LCD screen；
Step 4, user complete therapeutic process；
Data information after treatment is connect by communication unit with host computer and updates the data information by step 5, instrument.
The above description of disclosed embodiment of this invention enables professional and technical personnel in the field to realize or use this hair
It is bright.Various modifications to these embodiments will be apparent to those skilled in the art, and determine herein
The General Principle of justice can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, originally
Invention is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein
Consistent widest range.
Claims (10)
1. a kind of method that induced retinal generates and discharges dopamine and activate dopamine receptor D1, which is characterized in that it is logical
The wavelength that control is irradiated in the light of retina is crossed, the power of retina light is irradiated in, is irradiated in the time of retina light
The method that interruption and control are irradiated in the area of space of retina light is generated and is released to reach the cell on induced retinal
The purpose for putting dopamine, specifically includes,
Step 1 discharges the light irradiation eyeball of certain wavelength；
Step 2, interrupted illuminating；
Step 3 repeats step 1 and step 2.
2. a kind of method that induced retinal generates and discharges dopamine and activate dopamine receptor D1, which is characterized in that it is logical
The wavelength that control is irradiated in the light of retina is crossed, the power of retina light is irradiated in, is irradiated in the time of retina light
The method that interruption and control are irradiated in the area of space of retina light is generated and is released to reach the cell on induced retinal
The purpose for putting dopamine, specifically includes,
Step 1 discharges the light irradiation eyeball of certain wavelength；
Step 2, the light for discharging another certain wavelength irradiate eyeball；
Step 3, interrupted illuminating；
Step 4 repeats step 1 to three.
3. a kind of induced retinal according to claim 2 generates and discharges dopamine and activate the side of dopamine receptor D1
Method, which is characterized in that the range of light wavelengths are 650-680nm.
4. a kind of ophthalmic medical instrument, which is characterized in that it includes,
Pedestal, the support portion as entire instrument；
Control unit is used to control the operation of entire instrument, including signal input unit and information feedback unit；
Light source treatment unit, including eyepiece and the light source generation that is set to after eyepiece；
And Internet of Things net unit, it can be connect with host computer, realize wireless or wire communication.
5. a kind of ophthalmic medical instrument according to claim 4, which is characterized in that
The control circuit of power interface and control unit is provided in the pedestal；
The control unit includes touch liquid crystal display curtain, can be inputted to instrument by the LCD screen and instruct and pass through this
LCD screen feedback data information；
The Internet of Things net unit, including an information collection port and a wired or wireless data communication units,
By after the information collection port processing data information by communication unit and host computer realization write to each other, host computer into
The operation of remote control equipment is realized in the comparison of row data information.
6. a kind of ophthalmic medical instrument according to claim 4 or 5, which is characterized in that be provided on the pedestal
The rotating arm of support base, the support base and head is connected in one, and adjusts the rotation being set on the outside of rotating arm on two sides
Disk is to drive the head to do the adjusting of pitch angle；
The head section includes hood, and the eyepiece being set in hood, the light source generation includes light source base, institute
It is provided with laser generator in the light source base stated；
Uniform intensity generator is provided in the eyepiece；
It further include the interpupillary adjustment mechanism for adjusting distance between eyepiece.
7. a kind of ophthalmic medical instrument according to claim 6, which is characterized in that the laser generator includes accommodating
Cavity, the accommodating inside cavity are provided with spectroscope, be provided on the side wall of the accommodating cavity for light by
Access；
One end of the accommodating cavity is provided with laser diode, and the other end is provided with lens；
The rear end of the accommodating cavity is provided with circuit board；
And photodetector its connect the light that can receive to be projected by access with circuit board, and to circuit board feedback signal.
8. a kind of ophthalmic medical instrument according to claim 6, which is characterized in that the uniform intensity generator packet
It includes,
Transparent components,
Diffraction optical element,
And lens；
Wherein, the transparent components are made of a pair of of angle of wedge prism, and the angle of wedge prism includes prism one and prism two, institute
The right-angle plane for the prism one stated is arranged in opposite directions with the angle of wedge plane of prism two so that incident beam is through prism one and prism two
Light beam is become round by oval-shaped beam after refraction.
9. a kind of ophthalmic medical instrument according to claim 6, which is characterized in that the interpupillary adjustment mechanism includes two
A frame body, is provided with the hold assembly that object can be clamped on one of described frame body, and the one of another frame body
Side is provided with gear regulating mechanism；The gear regulating mechanism includes at least,
Cantilever frame body,
Gear, and
Adjusting handle, and the gear is engaged realization gear drive with adjusting handle；The adjusting handle can be around
It is rotated with cantilever frame body junction.
10. a kind of method using any ophthalmic medical instrument described in claim 4-9, which is characterized in that
Microchip carrier containing data information is positioned on the information collection port, the information collection end by step 1
Mouth will read the data information in microchip, and be write to each other by communication unit and host computer realization, and data are uploaded to
Position machine carries out data comparison；
Step 2, host computer will feed back a data information to the control circuit of control unit, control circuit after acquiring information
It will be decided whether to start instrument according to the data information of feedback；
Step 3, if starting instrument, then the control circuit of control unit can read the related data information in microchip, and root
Action is executed according to logic step, and by relevant marker information feedback on LCD screen；
Step 4, user complete therapeutic process；
Data information after treatment is connect by communication unit with host computer and updates the data information by step 5, instrument.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810110240.5A CN108309559A (en) | 2018-02-05 | 2018-02-05 | Induced retinal generates and discharges dopamine and activate the method and ophtalmic treatments instrument of dopamine receptor D1 |
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|---|---|---|---|
| CN201810110240.5A CN108309559A (en) | 2018-02-05 | 2018-02-05 | Induced retinal generates and discharges dopamine and activate the method and ophtalmic treatments instrument of dopamine receptor D1 |
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| CN109528459A (en) * | 2019-01-11 | 2019-03-29 | 徐春明 | A kind of eye-protecting instrument |
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