CN108241056A - Biological monitor - Google Patents
Biological monitor Download PDFInfo
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- CN108241056A CN108241056A CN201611205460.3A CN201611205460A CN108241056A CN 108241056 A CN108241056 A CN 108241056A CN 201611205460 A CN201611205460 A CN 201611205460A CN 108241056 A CN108241056 A CN 108241056A
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- resonant circuit
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
- G01N33/561—Immunoelectrophoresis
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
A kind of biological monitor, be set to comprising a substrate, one supply unit on the substrate, a detection unit being electrically connected with the supply unit and one with the collecting circuits of the detection unit adjacent spaces.The detection unit includes one first resonant circuit, first resonant circuit generates a resonant frequency, the electrical drive power towards the modified regions is generated between first resonant circuit and the collecting circuit, the suspended material stress in prepare liquid is made, which to be moved to calibration, the modified regions of specific detection body, it is easy to be combined with specific detection body, change effective dielectric coefficient of first resonant circuit, change the resonant frequency of first resonant circuit, by the knots modification for confirming the resonant frequency, you can judge testing result.
Description
Technical field
The present invention relates to a kind of biological monitor, more particularly to a kind of biological detection collected and analyzed for a specimen
Device.
Technical field
Refering to Fig. 1, in the related field of raw doctor's research, the detection of compatible host response is a kind of to be generally also in daily use very much
Detection technique.The main principle of compatible host response is to demarcate multiple antibody 11 with specificity on the specific area, passes through institute
The binding characteristic of antibody 11 and specific antigen 12 is stated, ingredient to be measured specific in sample to be detected is detected.However, due to
The size of antibody 11 and antigen 12 be all in nanometer grade, mainly can be due to antigen 12 be undersized during being detected
Brownian movement or concentration gradient diffusion are carried out, causes to be difficult to ensure that the problem of it contacts antibody 11 really and elongates detection time,
It also can be because of antibody 11 and the size relationship of antigen 12, it is difficult to directly observe it with reference to situation with the mode of vision to judge detection knot
Fruit.Therefore, the bottleneck that detection time how to be overcome to grow, and the result of detection is exported with specific aspect, for accurate
Judge testing result, then the important topic of research and development is actively improved as related field pursuer.
Microwave resonator is a kind of electric energy using specific frequency, thus the skill of resonant stationary wave is generated in specific cavity
Art can generate in specific cavity and stablize and be easy to the energy accurately measured.Raw doctor's detection is carried out for temperature in addition, being contemplated
The requirement for height of degree, sterilization etc., the electrical energy drive power that electrodynamics can be generated is that one kind is not easy to influence temperature, is also not required to
The noncontact driving power contacted by physical item, therefore quite it is suitably applied the driving of the raw doctor's detection of auxiliary.Therefore, how into
Work(integrates microwave resonator and electrodynamics, is the shortcomings that overcoming compatibility detection time longer, and precisely judges detection
As a result important key.
Invention content
The purpose of the present invention is to provide a kind of detection time is short, and can precisely judge the biological detection dress of testing result
It puts.Biological monitor of the present invention is used to provide electricity suitable for a prepare liquid containing suspended material, and comprising a substrate, one
Can supply unit, a detection unit being electrically connected with the supply unit and one with one section of the detection unit adjacent spaces away from
From collecting circuit.
The detection unit includes the first resonant circuit that a surface is formed with a modified regions, is demarcated in the modified regions
There are multiple specific detection bodies.
The collecting circuit is used to generate an electrical drive power towards the modified regions swimming jointly with first resonant circuit,
The prepare liquid by the electrical drive power act on, make suspended material towards the modified regions move, and with these specific detection body knots
Close, change the resonant frequency of the resonant circuit, according to the variation of resonant frequency, can in the interpretation prepare liquid suspended material and these
The bonding state of specific detection body.
The object of the invention to solve the technical problems also can be used following technical measures and further realize.
Preferably, aforementioned biological monitor, wherein, the first resonant circuit of the detection unit surrounds out a chamber
Room, and an opening with the chamber is defined between both ends.
Preferably, aforementioned biological monitor, wherein, effective dielectric coefficient existsWhen：
And effectively dielectric coefficient εeffBetween 1 to 10000；
Effective dielectric coefficient existsWhen：
And effectively dielectric coefficient εeffBetween 1 to 100；
According to formula (1) or formula (2), the length of first resonant circuit
Preferably, aforementioned biological monitor, wherein, the supply unit is defeated including an input terminal toward each other and one
Outlet and one generate the AC power of the electrical drive power for providing AC energy, which is disposed on
Between the input terminal and the output terminal.
Preferably, aforementioned biological monitor, wherein, which is formed at a part for the supply unit.
Preferably, aforementioned biological monitor, wherein, which is set in the opening, and towards this first
One end of resonant circuit, the modified regions are to extend internally at least one from one end of the first resonant circuit towards the collecting circuit
Segment distance.
Preferably, aforementioned biological monitor, wherein, which further includes a limit body, which encloses
Detection space of the tool there are one housing instills mouth is laid out, and the modified regions are located in the detection space.
Preferably, aforementioned biological monitor, wherein, the material of the limit body is silica gel, dimethyl silicone polymer or
Other electrically non-conductive materials of person.
Preferably, aforementioned biological monitor, wherein, the detection unit further include one be set in the chamber
Two resonant circuits, second resonant circuit surround out one and a notch connected with the room are defined between room and both ends.
Preferably, aforementioned biological monitor, wherein, the collecting circuit tool of the detection unit is there are one main paragraph, and two
It is a to extend respectively from the opposite end of the main paragraph towards the collecting circuit, and positioned at the effect of the collecting circuit two opposite sides
Section.
Preferably, aforementioned biological monitor, wherein, the AC power of the supply unit, in the every of the collecting circuit
Alternating current is passed between one acting section and first resonant circuit, makes to generate court between each acting section and first resonant circuit
To the electrical drive power of the modified regions.
Preferably, aforementioned biological monitor, wherein, the width of each acting section of the collecting circuit be less than this
The width of one resonant circuit.
Preferably, aforementioned biological monitor, wherein, the resonant frequency is between 0.3GHz between 100GHz.The present invention
Advantageous effect be：The electrical drive power generated between the collecting circuit and first resonant circuit can make outstanding in the prepare liquid
Float matter towards the modified regions move, increase the probability that these suspended materials are combined with these specific detection bodies, compared to
For the Brownian movement of machine or concentration gradient diffusion, the time of detection is effectively shortened；And the variation for passing through the resonant frequency
Judge testing result, the situation digitization that can be combined these suspended materials with these specific detection bodies judges to examine with accurate
The result of survey.
Description of the drawings
Fig. 1 is a schematic diagram, illustrates situation about being detected using compatible host response；
Fig. 2 is a vertical view, illustrates a first embodiment of biological monitor of the present invention；
Fig. 3 is a schematic diagram, illustrates the first resonant circuit of a detection unit of the first embodiment；
Fig. 4 is a schematic diagram, illustrates to connect electric power between the detection unit of the first embodiment and a collecting circuit；
Fig. 5 is a curve synoptic diagram, illustrates situation about being detected using the first embodiment；
Fig. 6 is a vertical view, illustrates a second embodiment of biological monitor of the present invention；
Fig. 7 is a partial enlarged view, and auxiliary Fig. 6 illustrates the detection unit of the second embodiment；
Fig. 8 is a schematic diagram, illustrates first resonant circuit and the collecting circuit of the second embodiment；And
Fig. 9 is a vertical view, illustrates a 3rd embodiment of biological monitor of the present invention.
Specific embodiment
The following describes the present invention in detail with reference to the accompanying drawings and embodiments：
Referring to Fig.2, a first embodiment of biological monitor of the present invention, suitable for detection one containing more suspended materials
Prepare liquid, and be electrically connected and connect with the supply unit 3 for providing the supply unit 3 and one of electric energy comprising a substrate 2, one
It receives the supply unit 3 and the detection unit 4 and one of electric energy and the collecting circuit 5 of 4 adjacent spaces of detection unit is provided.It will be first
Row explanation, the present invention carry out following illustrate, but the present invention is applicable mainly by taking these suspended materials is antigens as an example
Suspended material be not limited with antigen.In addition, the form depicted in Fig. 2 is only form of the one of which convenient for explanation, not
The exclusive architecture of the present invention.It is considered according to actual demand or test atmosphere etc., also can adjust the setting position of the supply unit 3
Put or adjust the true form of the detection unit 4.
The supply unit 3 is used to provide AC energy including an input terminal 31 toward each other and an output terminal 32 and one
AC power 33 (being illustrated in Fig. 4).And the detection unit 4 is disposed between the input terminal 31 and the output terminal 32, and including
One surrounds out the first resonant circuit 41 that an opening 411 connected with the chamber 410 is defined between a chamber 410 and both ends.Its
In, a Network Analyzer is connected between the input terminal 31 and the input terminal 32, for providing an electromagnetism to first resonant circuit 41
Wave signal.In this first embodiment, a first resonant circuit 41 preferably rectangle with the opening 411, and the collection
Circuit 5 is formed at a part for the supply unit 3, the preferably range around first resonant circuit 41.
Wherein, the material of first resonant circuit 41 and the collecting circuit 5 is able to the graphite or gold of selecting energy conductive
Belong to, and preferably utilize micro electronmechanical processing procedure, coordinate etching and processing and be made.Due to micro electronmechanical processing procedure various equivalent modifications according to
According to shown in Fig. 2, you can understand how after pattern is defined, utilized on the substrate 2 and be coated with photoresist, design light shield, exposure, show
The process of shadow, etching etc. and make the supply unit 3 and the detection unit 4, therefore details are not described herein.In addition to this, it uses
Such as screen painting, engraving processing procedure can also form the supply unit 3 and the detection unit 4 really.
The surface for defining first resonant circuit 41 is formed with towards the collecting circuit 5 and extends repairing at least a distance
It adorns region 419 (being shown in Fig. 4), being demarcated in the modified regions 419 has more specific detection bodies, these specific detection bodies are preferably adopted
With the correspondence antibody for the antigen type for being able to coordinate these suspended materials, using on the surface of 41 part of the first resonant circuit
It is surface-treated, the surface is made to generate specific functional group, and these function machines is made to be fixed on the surface really, it can
By the activity of the functional group, these antibody is made to generate bond with the functional group, whereby repair these antibody modifications in this
It adorns on region 419.It if, can also be according to demand it should be particularly noted that, the material of the collecting circuit 5 is able to equally be modified
And modify these antibody on the collecting circuit 5.
Refering to Fig. 2 and Fig. 3, due to the size and external form of the detection unit 4 and the resonant frequency of first resonant circuit 41
It is closely bound up, therefore must just existing fixed physical amount, the entire length surrounded for first resonant circuit 41 be calculated,
To design the size and external form of the suitable detection unit 4.The definition light velocity be C, resonant frequency f, effective dielectric coefficient
For εeff, the thickness of the substrate 2 is H, relative dielectric coefficient εr, the width of first resonant circuit 41 is W, length L, wave
Length is led as λ.Wherein, which existsWhen：
Via above-mentioned formula (1), and the size for coordinating the detection unit 4 easy to implement, effective dielectric coefficient εeffBetween 1
To between 10000.Effective dielectric coefficient existsWhen：
Via above-mentioned formula (2), and coordinate the size of 4 example easy to implement of detection unit, effective dielectric coefficient εeffBetween
Between 1 to 100.According to formula (1) or formula (2), the length of first resonant circuit 41
According to formula (3), the matrixed of detection device is contemplated, and considers to common caused by first resonant circuit 41
Vibration frequency need to be easy to generate by applying electromagnetic wave between the input terminal 31 of the supply unit 3 and the output terminal 32, the resonance
Frequency is between 100GHz, to control the length of first resonant circuit 41 in the scale model of millimeter to centimetre between 0.3GHz
It encloses, it is ensured that the embodiment dimensionally can also be appropriate for relevant life in the case where the energy range of electric energy is easy to acquirement
Doctor's analysis.
Refering to Fig. 2 and Fig. 4, the AC power 33 of the supply unit 3 is connected to first resonant circuit 41 and collection electricity
Between road 5, make between the collecting circuit 5 and first resonant circuit 41, generated due to the AC power 33 and be enough object is driven to move
Electrical drive power.Wherein, the generation of the electrical drive power mostlys come from three kinds of exchange electroosmotic flow, dielectrophoresis and electric heating machines
System.Exchange electroosmotic flow is taken place mostly in when granting ac potential on two parallel poles, and it is electric double that electrode attracts counter ions to be formed
Layer, by tangent line electric field action, ion can generate toward two electrode outer ends and stretch Coulomb force, and vortex is formed under alternating magnetic field.
And dielectrophoresis is then substance in liquid phase by electric field polarization degree difference, generates the positive dielectrophoresis toward strong electric field region movement, with
And the negative dielectrophoresis phenomenon with being moved toward negative electricity field areas.In addition, electric heating mechanism must cause Joule heat in electric current by solution
Effect generates certain temperature, can just generate vortex on the electrode.Above-mentioned three kinds of mechanism can all produce the specimen in solution
Raw effect, and these specimen is made to generate the mobile behavior of specific rule, therefore the range for generating the electrical drive power is instilled in solution
When, relative to these specimen is made to be moved naturally by Brownian movement or concentration gradient diffusion, these inspections certainly will can increased
Body contacts the probability of these specificities detection body within the unit interval, therefore can effectively shorten the time of reaction.It to be illustrated
It is to be directed to for present invention integration resonator and electrodynamic mode, as long as adjusting parameter, exchange electroosmotic flow, dielectric
Though swimming and electric heating phenomenon are all likely to occur, with regard to the electric energy and first resonant circuit used in the first embodiment
It is main or to exchange being affected for electroosmotic flow and dielectrophoresis mechanism for 41 form.
To first pass through electrical drive power caused by the AC power 33 when being actually detected, using the collecting circuit 5 into
The collection of the specific suspended material of row.After the collection action of specific suspended material, the AC power 33 is closed.Then, should
The Network Analyzer (Network Analyzer, figure in be not painted) connected between input terminal 31 and the output terminal 32, to this
One resonant circuit 41 inputs an electromagnetic wave signal, and first resonant circuit 41 is made to generate a resonant frequency.
Refering to Fig. 5 and coordinate Fig. 3, the present invention integrates the another object of resonator and electrical drive power, that is, is accurately
The testing result of compatible host response is judged with exact numerical values recited.According to formula (3), it is known that in light velocity C and the fixed feelings of waveguide length λ
Under condition, the square value of resonant frequency f is ε with effective dielectric coefficienteffIt is inversely proportional, therefore when the first resonant circuit 41 of the substrate 2
Or when on the collecting circuit 5 being collected into a specific specimen, the change of dielectric radio can cause resonant frequency to change.As shown in figure 5, it is
Using reflectance factor as the longitudinal axis, and the curve graph that frequency is actually measured for horizontal axis, the substrate 2 and first resonant circuit 41
Sequentially any processing is not being carried out, is generating functional group, with reference to specific detection body, fixed specific detection body, until specific detection body
Suspended material is captured, if being persistently detected in the process for the numerical value of frequency, frequency, which can be observed, can continue to generate displacement,
Variation according to the resonant frequency, you can judge immediately and accurately the bonding state of compatible host response whereby with exact numerical,
Obtain required testing result.
It is a second embodiment of biological monitor of the present invention, the second embodiment and the first embodiment refering to Fig. 6
The difference is that：The collecting circuit 5 is disposed in the opening 411, and towards one end of first resonant circuit 41, the modification
Region 419 is extended internally at least a distance from one end of the first resonant circuit 41 towards the collecting circuit 5.The detection list
Member 4 further includes a limit body 43 being set between first resonant circuit 41 and the collecting circuit 5.The collecting circuit 5 has one
A main paragraph 51, two extend respectively from the opposite end of the main paragraph 51 towards first resonant circuit 41, and positioned at this
The acting section 52 of one resonant circuit, 41 two opposite sides.If it should be particularly noted that, the material of the collecting circuit 5 is equally carried out
Modification can also modify these antibody, and collection electricity in the collecting circuit 5 according to demand along the acting section 52 for stretching both sides
The width of each acting section 52 on road 5 is less than the width of first resonant circuit 41.
Refering to Fig. 6 and Fig. 7, which, which surrounds out one, has the detection space 430 of a housing instills mouth, is carried out for limiting
The range of compatible host response, and the modified regions 419 are located in the detection space 430, therefore relatively can ensure that prepare liquid instills and be somebody's turn to do
When detecting in space 430, the suspended material in the prepare liquid, that is, coordinate the antigen of the antibody, it can be in the detection space
It is reacted, and be bonded to each other with specific detection body generation as far as possible in 430.The limit body 43 is preferably with silica gel, poly- two
Made by methylsiloxane (PDMS) or other non-conductive materials, wherein since silica gel has biocompatibility, although it is therefore right
When organism is detected, which will not influence the bioactivity of the specimen.
Refering to Fig. 8 and coordinate Fig. 6, when being detected using the second embodiment, the AC power 33 be connected to this
Between these acting sections 52 of one resonant circuit 41 and the collecting circuit 5, it is therefore an objective to make each acting section 52 and the first resonance electricity
The electrical drive power towards the modified regions 419 is generated between road 41.Wherein, the width of the acting section 52 of the collecting circuit 5, which is less than, is somebody's turn to do
The width of first resonant circuit 41, the second embodiment is different from the first embodiment in addition to the form of the collecting circuit 5, and volume
Outside the limit body 43 of outer one limitation detection range of setting, it is able to the detection identical with the first embodiment carry out.In addition to that can reach
The institute of the first embodiment is powerful outer, moreover it is possible to improve the accuracy of detection by limiting detection range.It is worth illustrating
, the limitation range of the limit body 43 can set according to the range for defining the modified regions 419, as long as can limit really
Detection range processed is not limited with the form shown in the attached drawing of this second embodiment and described in description.
It is a 3rd embodiment of biological monitor of the present invention, the 3rd embodiment and the second embodiment refering to Fig. 9
The difference is that：The detection unit 4 further includes second resonant circuit 44 being set in the chamber 410, the second resonance electricity
Road 44 surrounds out and a notch 441 connected with the room 440 is defined between a room 440 and both ends, the notch 441 and the opening
411 towards different directions, and the direction of the notch 441 and the opening 411 shown in Fig. 9 not to be limited.The second embodiment passes through
Second resonant circuit 44 can optimize the detection unit 4 and form coupling effect when resonating in specific frequency so that measure
When detection frequency when can more clearly judge to generate resonance, improve the accuracy of detection whereby.If it should be particularly noted that,
Also pass to electric energy between second resonant circuit 44 and first resonant circuit 41, also can first resonant circuit 41 and this second
The effect of electrical drive power being generated between resonant circuit 44, reaching the suspended material of driving prepare liquid, that is to say, that the second resonance electricity
Road 44 can also coordinate the needs that detection platform designs, and play the part of the role of the collecting circuit 5.
Claims (13)
1. a kind of biological monitor, suitable for detecting the prepare liquid containing more suspended materials；It is characterized in that：The biological detection
Device includes：
One plate base；
One supply unit, for providing electric energy；
One detection unit is electrically connected with the supply unit, and there are one the first of modified regions including a surface formation
Resonant circuit, in the modified regions calibration have multiple specific detection bodies；And
One collecting circuit has a distance with the detection unit adjacent spaces, for being generated jointly with first resonant circuit
Towards the electrical drive power of the modified regions swimming；
Wherein, which is acted on by the electrical drive power, and suspended material is made to be moved towards the modified regions, and with it is described special
It detects body to combine, changes the resonant frequency of the resonant circuit, it, can suspended matter in the interpretation prepare liquid according to the variation of resonant frequency
Matter and the bonding state of the specific detection body.
2. biological monitor as described in claim 1, it is characterised in that：First resonant circuit of the detection unit surrounds out
One chamber, and an opening with the chamber is defined between both ends.
3. biological monitor as described in claim 1, the definition light velocity is C, the resonant frequency is f, effective dielectric coefficient is
εeff, the substrate thickness be H, relative dielectric coefficient εr, and the width of first resonant circuit is W, length L, waveguide are long
It spends for λ, it is characterised in that：
Effective dielectric coefficient existsWhen：
And effectively dielectric coefficient εeffBetween 1 to 10000；
Effective dielectric coefficient existsWhen：
And effectively dielectric coefficient εeffBetween 1 to 100；
According to formula (1) or formula (2), the length of first resonant circuit
4. biological monitor as claimed in claim 2, it is characterised in that：The supply unit is defeated including one toward each other
Enter end and an output terminal and one for providing AC energy and generate the AC power of the electrical drive power, the detection
Unit is disposed between the input terminal and the output terminal.
5. biological monitor as described in claim 1, it is characterised in that：The collecting circuit is formed at the supply unit
A part.
6. biological monitor as claimed in claim 4, it is characterised in that：The collecting circuit is set in the opening, and court
To one end of first resonant circuit, which inwardly prolonged from first resonant circuit towards one end of the collecting circuit
Extend to few a distance.
7. biological monitor as claimed in claim 6, it is characterised in that：The detection unit further includes a limit body, should
Limit body surrounds out detection space of the tool there are one housing instills mouth, and the modified regions are located in the detection space.
8. biological monitor as claimed in claim 7, it is characterised in that：The material of the limit body is silica gel, poly dimethyl
Siloxanes or other electrically non-conductive materials.
9. biological monitor as claimed in claim 2, it is characterised in that：The detection unit further includes one and is set to the chamber
The second resonant circuit in room, which surrounds out one one is defined between room and both ends connects with the room
Notch.
10. biological monitor as claimed in claim 6, it is characterised in that：There are one the collecting circuit tools of the detection unit
Main paragraph, two extend respectively from the opposite end of the main paragraph towards the collecting circuit, and positioned at the collecting circuit opposite two
The acting section of side.
11. biological monitor as claimed in claim 10, it is characterised in that：The AC power of the supply unit, in the receipts
Alternating current is passed between each acting section of collector and first resonant circuit, makes each acting section and the first resonance electricity
The electrical drive power towards the modified regions is generated between road.
12. biological monitor as claimed in claim 10, it is characterised in that：The width of each acting section of the collecting circuit
Degree is less than the width of first resonant circuit.
13. biological monitor as described in claim 1, it is characterised in that：The resonant frequency is between 0.3GHz to 100GHz
Between.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611205460.3A CN108241056A (en) | 2016-12-23 | 2016-12-23 | Biological monitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611205460.3A CN108241056A (en) | 2016-12-23 | 2016-12-23 | Biological monitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108241056A true CN108241056A (en) | 2018-07-03 |
Family
ID=62704175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611205460.3A Pending CN108241056A (en) | 2016-12-23 | 2016-12-23 | Biological monitor |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292087A (en) * | 1998-02-02 | 2001-04-18 | 西格雷特生物科学有限公司 | Method and apparatus for detecting molecular binding events |
| TW200510716A (en) * | 2003-06-26 | 2005-03-16 | Nihon Dempa Kogyo Co | Crystal sensor |
| US7387889B2 (en) * | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
| CN101346627A (en) * | 2005-12-23 | 2009-01-14 | 皇家飞利浦电子股份有限公司 | Biosensor device |
| CN103459583A (en) * | 2011-03-08 | 2013-12-18 | 公立大学法人大阪府立大学 | Microorganism detection sensor and process for manufacturing same |
-
2016
- 2016-12-23 CN CN201611205460.3A patent/CN108241056A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1292087A (en) * | 1998-02-02 | 2001-04-18 | 西格雷特生物科学有限公司 | Method and apparatus for detecting molecular binding events |
| US7387889B2 (en) * | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
| TW200510716A (en) * | 2003-06-26 | 2005-03-16 | Nihon Dempa Kogyo Co | Crystal sensor |
| CN101346627A (en) * | 2005-12-23 | 2009-01-14 | 皇家飞利浦电子股份有限公司 | Biosensor device |
| CN103459583A (en) * | 2011-03-08 | 2013-12-18 | 公立大学法人大阪府立大学 | Microorganism detection sensor and process for manufacturing same |
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