CN108157661A - A kind of feed addictive for improving antibody titer and preparation method thereof - Google Patents
A kind of feed addictive for improving antibody titer and preparation method thereof Download PDFInfo
- Publication number
- CN108157661A CN108157661A CN201711492303.XA CN201711492303A CN108157661A CN 108157661 A CN108157661 A CN 108157661A CN 201711492303 A CN201711492303 A CN 201711492303A CN 108157661 A CN108157661 A CN 108157661A
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- CN
- China
- Prior art keywords
- parts
- feed addictive
- antibody titer
- vaccine
- sorbierite
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
Abstract
The present invention relates to a kind of feed addictives for improving antibody titer and preparation method thereof, and the component and its ratio of weight and number of feed addictive are:15 30 parts of L arginine monohydrochlorides, 15 20 parts of sorbierite, 15 10 parts of D oligosaccharides, 10 30 parts of DEXTROSE ANHYDROUS, 10 20 parts of oligofructose, 10 20 parts of white granulated sugar.The present invention has and can be used simultaneously with vaccine, convenient easily storage, the advantages such as cheap；This product can also cooperate with vaccine activating immune system while energy is provided to chicken group, increase cell and humoral immunity, improve the antibody titer and regularity after vaccine immunity, generation antibody height is avoided to differ, chicken weak to chicken group, that regularity is poor, disease takes place frequently is all risen to health care, improve disease resistance, enhancing valence of vaccine antibody level and regularity.
Description
Technical field
The invention belongs to feed additive field, especially a kind of feed addictive for improving antibody titer and its preparation side
Method.
Background technology
As the food-safe consciousness of people is constantly strengthened, the requirement exported to poultry medicament residue is more and more stringenter,
Forbid adding antibiotic and chemicals component additive agent, become the key of development green cultivation.Then some communicable diseases
Vaccine has obtained popularizing opportunity well, and freeze-dried vaccine and inactivated vaccine all incorporate cultivation vaccine program respectively in biological products
In, but during its clinical use, the height of antibody level after being immunized, immune regularity, entire chicken group after being immunized
State all differs, wherein the health status of chicken group, the popularity of the approach of vaccine used, at that time disease, immunoprotection of drinking water
Use, the hardness of water and PH etc. all has an impact vaccine, and how to improve the antibody titer of vaccine and regularity becomes our beasts
Cure the focus of a very long time of R＆D worker.
Invention content
An object of the present invention be to provide it is a kind of improve antibody titer feed addictive, the feed addictive have make
With conveniently, cheap, easy the features such as storing, can cooperate with the immune decorum of vaccine activation, increase cell and humoral immunity, raising epidemic disease
The regularity of rear antibody level is immunized in seedling, improves valence of vaccine antibody；Vaccine valence is protected not to be damaged, it can with less antigen
To play higher antibody level；
The second object of the present invention is to provide a kind of preparation method for the feed addictive for improving antibody titer.
The present invention is achieved through the following technical solutions：
A kind of feed addictive for improving antibody titer, the component and its ratio of weight and number of feed addictive are：
Moreover, the component of the feed addictive and its optimal ratio of weight and number are：
A kind of preparation method for the feed addictive for improving antibody titer, the step of preparation method be：
(1) L-arginine hydrochloride weighed respectively according to weight proportion, and sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS is oligomeric
Fructose, white granulated sugar carry out 100 mesh sievings, screenings are crushed and sieved with 100 mesh sieve；The requirement control of whole process environment temperature exists
18-25 DEG C, humid control is below 50%；
(2) by the L-arginine hydrochloride after sieving, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar
It is respectively put into and is dried under reduced pressure in case 45 degree of dryings 5 hours；
(3) by dried L-arginine hydrochloride, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar
It is put into after mixing in three-dimensional mixer mixing tank, uniformly mixing is added for 35 minutes to get to a kind of feed for improving antibody titer
Agent finished product.
Advantages of the present invention and advantageous effect are：
1. the present invention can increase the immunity of body, immune cell activated is generated more preferable with less antigenic stimulus body
Antibody titer, i.e., it is cost-effective and safe to use；
2. the present invention containing D- oligosaccharides and sorbierite can protect vaccine antigen it is various stress under be not damaged, body is allowed to obtain
Better immune response is obtained, generates better antibody protection；Activated lymphocyte, promotes lymphocyte transformation, and increment is divided into
Sensitized lymphocyte improves responsing reaction of the body immune system to boosting vaccine；
3. the present invention can improve the antibody titer and the uniformity of vaccine, antibody level is avoided to differ the health status brought
Differ, it is whole to improve chicken group's health status, save cost for aquaculture；
Specific embodiment
The present invention is described in further detail by following embodiment.It should be noted that：Following embodiments are illustrative, are not
It is limited, it is impossible to limit protection scope of the present invention with following embodiments.
L-arginine hydrochloride in the present invention, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar are equal
It can be commercially available on the market.
Embodiment 1
A kind of feed addictive for improving antibody titer, the component and its weight of feed addictive are respectively：L- essence ammonia
20 parts of acid hydrochloride, 15 parts of sorbierite, 15 parts of D- oligosaccharides, 15 parts of DEXTROSE ANHYDROUS, 20 parts of oligofructose, 15 parts of white granulated sugar.
A kind of preparation method for the feed addictive for improving antibody titer, the step of preparation method be：
(1) L-arginine hydrochloride is weighed respectively according to weight proportion, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS is oligomeric
Fructose, white granulated sugar carry out 100 mesh sievings, screenings are crushed and sieved with 100 mesh sieve；The requirement control of whole process environment temperature exists
18-25 DEG C, humid control is below 50%；
(2) by the L-arginine hydrochloride after sieving, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar
It is respectively put into and is dried under reduced pressure in case 45 degree of dryings 5 hours；
(3) by dried L-arginine hydrochloride, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar
It is put into after mixing in three-dimensional mixer mixing tank, uniformly mixing is added for 35 minutes to get to a kind of feed for improving antibody titer
Agent finished product.
Embodiment 2
A kind of feed addictive for improving antibody titer, the component and its weight of feed addictive are respectively：L- essence ammonia
15 parts of acid hydrochloride, 15 parts of sorbierite, 20 parts of D- oligosaccharides, 15 parts of DEXTROSE ANHYDROUS, 20 parts of oligofructose, 15 parts of white granulated sugar.
The step of preparation method, is the same as embodiment 1.
Embodiment 3
A kind of feed addictive for improving antibody titer, the component and its weight of feed addictive are respectively：L- essence ammonia
20 parts of acid hydrochloride, 15 parts of sorbierite, 20 parts of D- oligosaccharides, 20 parts of DEXTROSE ANHYDROUS, 15 parts of oligofructose, 15 parts of white granulated sugar.
The step of preparation method, is the same as embodiment 1.
Clinical practice
Experiment one：The present invention promotes AA chick ND immune effect of vaccine the influence of titre
Materials and methods：
1.1 experimental animals are grouped
The raising of 1 aa broiler chicken 30, for testing, chick stochastic averagina is divided into and uses of the present invention group to 7 ages in days, blank
Control group is immunized without using of the present invention group；Vaccine used is newcastle disease freeze-dried vaccine, and Harbin Wei Ke Technology Co., Ltd. produces；
Vaccine dosage is used according to label specification standard；
1.2 test method
The measure of antibody level, using Microhemagglutination (HA) and hemagglutination-inhibition test (HI) testing inspection newcastle epidemic disease antibody,
2 results
The blood serum sample of 5 acquisitions is measured into antibody titres to newcastle disease virus, the newcastle epidemic disease antibody result knot of each group difference Zhou Ling
Fruit is as follows：
Test result analysis
Conclusion：For additive of the present invention to vaccine antibody regularity, titre has good castering action seedling to have well
Protective effect, allows the reservation peak state of antibody level long period.
Claims (3)
1. a kind of feed addictive for improving antibody titer, it is characterised in that：The component and its parts by weight of the feed addictive
Than for：
2. a kind of feed addictive for improving antibody titer according to claim 1, it is characterised in that：The feed addictive
Component and its optimal ratio of weight and number be：
3. a kind of a kind of feed addictive for improving antibody titer as described in claim 1 and preparation method thereof, feature exists
In：The step of preparation method is：
(1) L-arginine hydrochloride weighed respectively according to weight proportion, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose,
White granulated sugar carries out 100 mesh sievings, and oversize is crushed and sieved with 100 mesh sieve；The requirement control of whole process environment temperature is in 18-25
DEG C, humid control is below 50%；
(2) by the L-arginine hydrochloride after sieving, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar difference
It is put into and is dried under reduced pressure in case 45 degree of dryings 5 hours；
(3) by dried L-arginine hydrochloride, sorbierite, D- oligosaccharides, DEXTROSE ANHYDROUS, oligofructose, white granulated sugar mixing
After be put into three-dimensional mixer mixing tank, uniformly mixing 35 minutes to get to it is a kind of improve antibody titer feed addictive into
Product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711492303.XA CN108157661A (en) | 2017-12-30 | 2017-12-30 | A kind of feed addictive for improving antibody titer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711492303.XA CN108157661A (en) | 2017-12-30 | 2017-12-30 | A kind of feed addictive for improving antibody titer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108157661A true CN108157661A (en) | 2018-06-15 |
Family
ID=62516875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711492303.XA Withdrawn CN108157661A (en) | 2017-12-30 | 2017-12-30 | A kind of feed addictive for improving antibody titer and preparation method thereof |
Country Status (1)
| Country | Link |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101611763A (en) * | 2009-07-15 | 2009-12-30 | 四川农业大学 | A kind of feed addictive that improves valence of vaccine antibody |
| CN102459568A (en) * | 2009-05-26 | 2012-05-16 | 先进生物营养公司 | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| CN103405490A (en) * | 2013-08-23 | 2013-11-27 | 卢颖 | Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof |
-
2017
- 2017-12-30 CN CN201711492303.XA patent/CN108157661A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102459568A (en) * | 2009-05-26 | 2012-05-16 | 先进生物营养公司 | Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making |
| CN101611763A (en) * | 2009-07-15 | 2009-12-30 | 四川农业大学 | A kind of feed addictive that improves valence of vaccine antibody |
| CN103405490A (en) * | 2013-08-23 | 2013-11-27 | 卢颖 | Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 丁壮等: "《新城疫及其防制》", 31 May 2005, 金盾出版社 * |
| 姜锡瑞等: "《生物发酵产业技术》", 31 May 2016, 中国轻工业出版社 * |
| 聂芙蓉等: "《饲料添加剂安全应用关键技术》", 30 September 2016, 中原农民出版社 * |
| 黄志坚: "《农业科学与农业产业化丛书 现代兽医技术》", 30 June 2011, 湖南科学技术出版社 * |
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| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180615 |
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| WW01 | Invention patent application withdrawn after publication |