CN108114327A - A kind of operation biomembrane - Google Patents
A kind of operation biomembrane Download PDFInfo
- Publication number
- CN108114327A CN108114327A CN201810120265.3A CN201810120265A CN108114327A CN 108114327 A CN108114327 A CN 108114327A CN 201810120265 A CN201810120265 A CN 201810120265A CN 108114327 A CN108114327 A CN 108114327A
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- CN
- China
- Prior art keywords
- biomembrane
- hypothallus
- coating
- operation biomembrane
- ossein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention provides a kind of operation biomembrane, and the operation biomembrane is made of hypothallus with the coating being wrapped in outside the hypothallus.The operation biomembrane of the present invention, is made of the macromolecule of Bioabsorbable, has good biocompatibility, and tissue reaction is light, can be by biological decomposition and absorption, and tensile strength is high.
Description
Technical field
The present invention relates to medicine and hygiene fields, and in particular to a kind of operation biomembrane.
Background technology
Intraperitoneal parenchymal viscera, such as liver,spleen,kidney blood circulation are enriched, and envelope is thin, and tissue is fragile, wound and hand
Art hemostasis, reparation are all more difficult.The internal organs of gastrointestinal tract cavity have wriggling function, and intracavitary has liquid, gas, when peritonitis occurs and
After operation, enterocinesia weakens, and the big quantity of fluid of intracavitary and gas are detained, and pressure increases, and causes gastrointestinal wall relatively thinning, and tension increases
Height, inflammatory edema make tissue fragile.Due to these anatomical physiology pathological characteristics, the reparation for causing internal organs is difficult, must not in operation
It does not partly cut off internal organs or even entirely cuts off internal organs, the postoperative generation bleeding that has, intestines impotence, adhesive ileus or even jeopardize life
Life.Therefore, in abdominal postoperative, the pulling force that biomembrane enhancing internal organs tolerance need to be applied to knot promotes local woanded surface healing, prevents
Intestines impotence prevents intestinal adhesion.
Biomembrane need to meet absorbable requirement, and the need of Absorbable membranes meet is not only that tissue reaction is light, day
So degradable, nontoxic, the reliable biological property requirement of Vapor recovery unit, also needs to meet the high physical property requirements of tensile strength.
In consideration of it, urgently propose a kind of tissue reaction light, natural degradable at present, nontoxic, Vapor recovery unit is reliable, and resist
The high operation biomembrane of tensile strength.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of light tissue reaction, natural degradable, nontoxic, absorption surely
It is fixed reliable, and the operation biomembrane that tensile strength is high.
For this purpose, the present invention provides a kind of operation biomembrane, the operation biomembrane is by hypothallus and is wrapped in described
Coating outside hypothallus is formed；Wherein, the hypothallus includes polycaprolactone；The coating includes ossein.
Preferably, the hypothallus also includes chitosan.
Preferably, the coating also includes poly butyric ester.
Preferably, the coating is obtained by the reaction for the ossein with the poly butyric ester by heat cross-linking.
Preferably, in the ossein and the poly butyric ester heat cross-linking reaction process, it is also added into alginic acid
Sodium.
Preferably, the ossein and the dosage of the poly butyric ester are 1：The weight ratio of (1~3).
Preferably, the dosage of the polycaprolactone and the chitosan is 5：The weight ratio of (2~7).
Technical solution provided by the invention, has the following advantages that：
1st, operation biomembrane of the present invention, is made of the macromolecule of Bioabsorbable, has good life
Object compatibility, can be by biological decomposition and absorption, not remaining foreign matter；
2nd, operation biomembrane of the present invention has the double-layer structure of hypothallus and coating so that operation biology
The tensile strength of film is high.Wherein, hypothallus include polycaprolactone, the polycaprolactone in vivo with biological cell compatibility very
It is good, cell can on its pedestal normal growth, and can be biodegradable into CO2And H2O.Also comprising chitosan, chitosan is the hypothallus
A kind of natural polymer, biological functionality and compatibility, blood compatibility, security, microbic resolvability are excellent, for this
The invention operation biomembrane, has preferable adsorptivity, can preferably be combined with coating.The coating includes gelatine
Original, ossein are called tectine matter, account for the 30%~40% of human body protein total amount, be form human muscle, skin it is important
Ingredient has very great help for the elasticity of the toughness of holding bone, the harmony of human motion and skin.The coating also includes
Poly butyric ester, poly butyric ester is nontoxic and biodegradable, so without being removed after wound healing, and it has
Preferable thermoplasticity can improve the toughness and tensile strength of biomembrane for operation biomembrane.
Specific embodiment
Embodiment 1
The operation biomembrane of the present embodiment is made of hypothallus with the coating being wrapped in outside the hypothallus；Wherein,
The hypothallus includes polycaprolactone and chitosan；The coating includes ossein and poly butyric ester.
Its preparation method is as follows：
(1) 20g polycaprolactones, 8g chitosans are taken, is mixed uniformly, being heated to 120 DEG C makes its fusing, removes bubble
Afterwards, by casting film-forming, that is, hypothallus is formed；
(2) 20g osseins particulate abrasive is weighed to powdered, is added it in the water of 20ml, is added the poly- hydroxyls of 20g
Butyrate stirs evenly；10g sodium alginates are weighed, are added in mixed solution, are first quickly stirred with 200r/min 1-2 minutes,
Then stirred 10 minutes with 100r/min again, after mixing, mixed solution is heated to 60 DEG C, that is, after generating heat cross-linking
Coating solution；
(3) hypothallus obtained in step (1) is taken, is impregnated in the coating solution obtained in step (2), is soaked
After stain 0.5h, then 2h is freeze-dried at -20 DEG C, repeated impregnations, freezing dry process 1 time are to get the operation biomembrane.
Embodiment 2
The operation biomembrane of the present embodiment is made of hypothallus with the coating being wrapped in outside the hypothallus；Wherein,
The hypothallus includes polycaprolactone and chitosan；The coating includes ossein and poly butyric ester.
Its preparation method is as follows：
(1) 20g polycaprolactones, 28g chitosans are taken, is mixed uniformly, being heated to 160 DEG C makes its fusing, removes bubble
Afterwards, by casting film-forming, that is, hypothallus is formed；
(2) 20g osseins particulate abrasive is weighed to powdered, is added it in the water of 120ml, is added the poly- hydroxyls of 20g
Base butyrate, stirs evenly；10g sodium alginates are weighed, are added in mixed solution, 1-2 points are first quickly stirred with 100r/min
Then clock is stirred 30 minutes again with 50r/min, after mixing, mixed solution is heated to 40 DEG C, that is, after generating heat cross-linking
Coating solution；
(3) hypothallus obtained in step (1) is taken, is impregnated in the coating solution obtained in step (2), is soaked
After stain 1h, then 5h is freeze-dried at -40 DEG C, repeated impregnations, freezing dry process 3 times are to get the operation biomembrane.
Embodiment 3
The operation biomembrane of the present embodiment is made of hypothallus with the coating being wrapped in outside the hypothallus；Wherein,
The hypothallus includes polycaprolactone and chitosan；The coating includes ossein and poly butyric ester.
Its preparation method is as follows：
(1) 20g polycaprolactones, 28g chitosans are taken, is mixed uniformly, being heated to 160 DEG C makes its fusing, removes bubble
Afterwards, by casting film-forming, that is, hypothallus is formed；
(2) 20g osseins particulate abrasive is weighed to powdered, is added it in the water of 120ml, is added the poly- hydroxyls of 60g
Base butyrate, stirs evenly；10g sodium alginates are weighed, are added in mixed solution, 1-2 points are first quickly stirred with 100r/min
Then clock is stirred 30 minutes again with 50r/min, after mixing, mixed solution is heated to 80 DEG C, that is, after generating heat cross-linking
Coating solution；
(3) hypothallus obtained in step (1) is taken, is impregnated in the coating solution obtained in step (2), is soaked
After stain 3h, then 5h is freeze-dried at -40 DEG C, repeated impregnations, freezing dry process 3 times are to get the operation biomembrane.
Experimental example
To verify the technique effect of operation biomembrane of the present invention, for the institute being prepared in embodiment 1-3
It states operation and carries out following experiment with biomembrane：
The rabbit 6 of 3 ± 0.5kg of weight is taken, is divided into 3 groups, 1 group of -3 group of embodiment is denoted as respectively, after anesthesia, to rabbit
Carry out abdominal operation.After 6 rabbits have been carried out with postoperative disinfect, implement abdomen center and operates on, and respectively using real
The operation biomembrane fitting wound being prepared in a 1-3 is applied, biomembrane does not occur breaking situation in surgical procedure, passes through
The fracture strength for testing the Absorbable membranes is 8-10CN/dtex.Behind 2 months of suture, then abdominal cavity is carried out to 6 rabbits
Abdominal cavity is opened in operation, observes biomembrane absorbing state.
By above-mentioned experiment, following result is obtained：The operation being prepared in embodiment 1-3 is applied to biomembrane
Rabbit.After 2 months, the operation biomembrane is absorbed substantially.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (7)
1. a kind of operation biomembrane, which is characterized in that the operation biomembrane is by hypothallus and is wrapped in the hypothallus
External coating is formed；Wherein, the hypothallus includes polycaprolactone；The coating includes ossein.
2. according to the operation biomembrane described in claim 1, which is characterized in that the hypothallus also includes chitosan.
3. according to the operation biomembrane described in claim 2, which is characterized in that the coating also includes poly butyric
Ester.
4. according to the operation biomembrane described in claim 3, which is characterized in that the coating for the ossein with it is described
Poly butyric ester is obtained by the reaction by heat cross-linking.
5. according to the operation biomembrane described in claim 4, which is characterized in that in the ossein and the poly- hydroxyl fourth
In acid esters heat cross-linking reaction process, sodium alginate is also added into.
6. according to the operation biomembrane described in claim 5, which is characterized in that the ossein and the poly butyric
The dosage of ester is 1：The weight ratio of (1~3).
7. the operation biomembrane according to any one in claim 1-6, which is characterized in that the polycaprolactone and institute
The dosage for stating chitosan is 5：The weight ratio of (2~7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120265.3A CN108114327A (en) | 2018-02-07 | 2018-02-07 | A kind of operation biomembrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810120265.3A CN108114327A (en) | 2018-02-07 | 2018-02-07 | A kind of operation biomembrane |
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| Publication Number | Publication Date |
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| CN108114327A true CN108114327A (en) | 2018-06-05 |
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| CN201810120265.3A Pending CN108114327A (en) | 2018-02-07 | 2018-02-07 | A kind of operation biomembrane |
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Citations (8)
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|---|---|---|---|---|
| WO1993022360A1 (en) * | 1992-04-24 | 1993-11-11 | The Polymer Technology Group, Inc. | Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range |
| EP1688152A1 (en) * | 2001-12-13 | 2006-08-09 | Nipro Corporation | Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same |
| CN101932344A (en) * | 2007-12-18 | 2010-12-29 | 伊西康公司 | Surgical barriers with adhesion inhibiting properties |
| CN102716517A (en) * | 2011-03-30 | 2012-10-10 | 深圳兰度生物材料有限公司 | Guided tissue regeneration membrane and its preparation method |
| CN104168925A (en) * | 2012-02-29 | 2014-11-26 | 胶原基质公司 | Collagen-coated tissue based membranes |
| CN105999405A (en) * | 2016-05-19 | 2016-10-12 | 李世荣 | Absorbable fundal mesh composite and preparation method thereof |
| CN106310373A (en) * | 2015-07-09 | 2017-01-11 | 陕西佰傲再生医学有限公司 | Biological repair membrane and preparation method thereof |
| CN106474548A (en) * | 2015-08-28 | 2017-03-08 | 北京华信佳音医疗科技发展有限责任公司 | A kind of biological induction type artificial dura mater and preparation method thereof |
-
2018
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993022360A1 (en) * | 1992-04-24 | 1993-11-11 | The Polymer Technology Group, Inc. | Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecular weight range |
| EP1688152A1 (en) * | 2001-12-13 | 2006-08-09 | Nipro Corporation | Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same |
| CN101932344A (en) * | 2007-12-18 | 2010-12-29 | 伊西康公司 | Surgical barriers with adhesion inhibiting properties |
| CN102716517A (en) * | 2011-03-30 | 2012-10-10 | 深圳兰度生物材料有限公司 | Guided tissue regeneration membrane and its preparation method |
| CN104168925A (en) * | 2012-02-29 | 2014-11-26 | 胶原基质公司 | Collagen-coated tissue based membranes |
| CN106310373A (en) * | 2015-07-09 | 2017-01-11 | 陕西佰傲再生医学有限公司 | Biological repair membrane and preparation method thereof |
| CN106474548A (en) * | 2015-08-28 | 2017-03-08 | 北京华信佳音医疗科技发展有限责任公司 | A kind of biological induction type artificial dura mater and preparation method thereof |
| CN105999405A (en) * | 2016-05-19 | 2016-10-12 | 李世荣 | Absorbable fundal mesh composite and preparation method thereof |
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| Title |
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Application publication date: 20180605 |