CN108096276A - A kind of debridement healing washing lotion and its application - Google Patents
A kind of debridement healing washing lotion and its application Download PDFInfo
- Publication number
- CN108096276A CN108096276A CN201810190525.4A CN201810190525A CN108096276A CN 108096276 A CN108096276 A CN 108096276A CN 201810190525 A CN201810190525 A CN 201810190525A CN 108096276 A CN108096276 A CN 108096276A
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- Prior art keywords
- healing
- debridement
- washing lotion
- wound
- skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention discloses a kind of debridement healing washing lotion and its application, and debridement healing washing lotion, to numerical value >=5, has great broad-spectrum antibacterial, bactericidal effect to the killing of staphylococcus aureus, pseudomonas aeruginosa, Escherichia coli and Candida albicans.Zoopery shows that after debridement of the invention healing washing lotion processing wound, surface of a wound closed index is significantly improved compared with comparison medicine, can effectively inhibit wound infection, promotes wound healing, accelerates speed of wound healing.Skin irritation evaluation test is shown, the present invention debridement healing washing lotion processing damaged skin after, within the observation period damaged skin without erythema, without redness, primary stimulus index K=0, and other abnormal conditions of skin part are not found, it has no stimulation to damaged skin.It in addition, the ingredient used in the present invention is cheap, derives from a wealth of sources, is a kind of low cost, the good debridement healing drug of effect, Wound healing and bone regeneration caused by being suitable for all kinds of surgical operations, accident trauma is worth of widely use.
Description
Technical field
The present invention relates to pharmaceutical technology fields, are a kind of debridement healing washing lotion and its application specifically.
Background technology
Wound refers to that mechanicalness tissue continuity of causing injury caused by the factor destroys or dysfunction.After wound healing is wound
Pathologic process, can be cicatrized a wound under normal circumstances by self regulatory function, this process can substantially be attributed to following several
A stage：(1) the inflammatory reaction stage, typically last for the time more than 24 it is small when.At this stage, phagocyte, neutral grain are thin
The inflammatory cells such as born of the same parents, which largely enter in wound matrix, to be decomposed, swallows dead cell, removes wound foreign matter.(2) granulation tissue generation rank
Section, the migration of epithelial cells in this stage near wound substitutes the cell of dead to the surface of a wound, after wound occurs about 4 days,
Micro- phagocyte, fibroblast and endothelial cell start hyperplasia, form a large amount of capilary granulation tissues, and the surface of a wound is gradually thin by epithelium
Born of the same parents are completely covered.(3) surface of a wound remodelling phase, capillary quantity are reduced gradually, and tissue gradually becomes close, and appearance tends to just
Often.
Cleaning is an important step for the treatment of of wounds, the purpose is to remove the tissue of devitalization as early as possible, makes to have polluted
Wound become fresh and clean wound, heal as early as possible the good condition of wound for wound.The prior art is clear for skin degerming
The key agents of wound have medicinal alcohol, liquor iodi mitis, Iodophor, furacilin solution, bromogeramine solution etc., however clinical practice is sent out
The irritation that these existing drugs have is too strong, it is impossible to which large-area applications, some clinical debridement effects are undesirable or even have allergic reaction.Separately
Outside, function of these drugs without promoting wound reparation.The processing of modern Western medicine surgery traumatic wounds caused by operation
Method is to wound sterilizing, disinfection, to prevent from infecting using antibiotic, the method wrapped up with hospital gauze after sewing up a wound, wound
Healing be to be repaired by the tissue of body itself, wound healing is slow.
Chinese patent 2010100195177 discloses a kind of Wound antibiotic flushing fluid and preparation method thereof, and composition of raw materials is such as
Under：(1) chlorhexidine acetate 0.5g, (2) silver nitrate 500 μ g, (3) absolute ethyl alcohol 10ml, (4) glycerine 10ml, (5) Acritamer 940
0.5g, (6) Tween 80 5g, (7) phosphoric acid 5g, (8) deionized water surplus 70ml.Chinese patent 2017100589062 is open a kind of
For the pharmaceutical composition of wound healing, including oxidant, zinc sulfate and sodium chloride, by zinc sulfate and oxidant collectively as medicine
Compositions ingredient so that the pharmaceutical composition except with good killing bacterium, fungi, spore effect, also have aobvious
Write the effect that ground promotes wound healing.However in the prior art, the debridement healing washing lotion on the present invention, yet there are no report
Road.
The content of the invention
First purpose of the present invention is for deficiency of the prior art, provides a kind of debridement healing washing lotion.
Second object of the present invention is for deficiency of the prior art, provides a kind of promotion wound healing medicine
Preparation.
Third object of the present invention is that the use of debridement healing washing lotion as described above is provided for deficiency of the prior art
On the way.
To realize above-mentioned first purpose, the present invention adopts the technical scheme that：
A kind of debridement healing washing lotion, the ingredient and content of the debridement healing washing lotion are：
As the preferred embodiment of the present invention, the ingredient and content of the debridement healing washing lotion are：
As the preferred embodiment of the present invention, the ingredient and content of the debridement healing washing lotion are：
To realize above-mentioned second purpose, the present invention adopts the technical scheme that：
A kind of promotion wound healing pharmaceutical preparation, is packaged with debridement including sealing container, in the sealing container and is cured
Close washing lotion；The ingredient and content of debridement healing washing lotion be：Hypochlorous acid 0.01-0.1%, sodium chloride 0.1-1.0%, chitosan
Quaternary ammonium salt 2-5%, acetic acid chlorhexidine 0.1-1%, benzalkonium bromide 0.01-0.05%, deionized water surplus；The sealing container with
Debridement healing washing lotion ingredient does not chemically react.
To realize above-mentioned 3rd purpose, the present invention adopts the technical scheme that：
Application of the debridement healing washing lotion as described above in the drug for promoting wound healing is prepared.
Compared with prior art, the beneficial effects of the invention are as follows：The debridement healing washing lotion of the present invention is using hypochlorous acid, chlorination
Sodium, chitosan quaternary ammonium salt, acetic acid chlorhexidine, benzalkonium bromide and deionized water mix according to a certain percentage, to golden yellow grape
The killing of coccus, pseudomonas aeruginosa, Escherichia coli and Candida albicans has great broad-spectrum antibacterial, kills to numerical value >=5
Bacterium acts on.Zoopery shows that after debridement of the invention healing washing lotion processing wound, surface of a wound closed index is significantly carried compared with comparison medicine
Height, wound infection can effectively be inhibited by illustrating the debridement healing washing lotion of the present invention, promoted wound healing, accelerated speed of wound healing.
Skin irritation evaluation test is shown, after debridement of the invention healing washing lotion processing damaged skin, the damaged skin within the observation period
Without erythema, without redness, primary stimulus index K=0, and other abnormal conditions of skin part are not found, to damaged skin
It has no stimulation.In addition, the ingredient used in debridement healing washing lotion is cheap, derives from a wealth of sources, be a kind of low cost, effect is good
Debridement healing drug, Wound healing and bone regeneration caused by being suitable for all kinds of surgical operations, accident trauma is worth of widely use
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It is to be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after the content of the invention recorded has been read, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed scope.In following embodiment, the chitosan quaternary ammonium salt is purchased from Guangzhou Hua Yun bio tech ltd, article No.
S12716。
Embodiment 1
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.05%, sodium chloride 0.5%, chitosan quaternary ammonium salt
3%th, acetic acid chlorhexidine 0.6%, benzalkonium bromide 0.03%, deionized water surplus.
Embodiment 2
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.01%, sodium chloride 0.1%, chitosan quaternary ammonium salt
5%th, acetic acid chlorhexidine 1%, benzalkonium bromide 0.05%, deionized water surplus.
Embodiment 3
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.02%, sodium chloride 0.2%, chitosan quaternary ammonium salt
4%th, acetic acid chlorhexidine 0.8%, benzalkonium bromide 0.04%, deionized water surplus.
Embodiment 4
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.04%, sodium chloride 0.4%, chitosan quaternary ammonium salt
4%th, acetic acid chlorhexidine 0.6%, benzalkonium bromide 0.04%, deionized water surplus.
Embodiment 5
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.06%, sodium chloride 0.6%, chitosan quaternary ammonium salt
3%th, acetic acid chlorhexidine 0.4%, benzalkonium bromide 0.03%, deionized water surplus.
Embodiment 6
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.08%, sodium chloride 0.8%, chitosan quaternary ammonium salt
3%th, acetic acid chlorhexidine 0.2%, benzalkonium bromide 0.02%, deionized water surplus.
Embodiment 7
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.1%, sodium chloride 1.0%, chitosan quaternary ammonium salt
2%th, acetic acid chlorhexidine 0.1%, benzalkonium bromide 0.01%, deionized water surplus.
Comparative example 1
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.05%, sodium chloride 0.5%, chitosan quaternary ammonium salt
3%th, deionized water surplus.
Comparative example 2
A kind of debridement healing washing lotion, ingredient and content are：Hypochlorous acid 0.05%, sodium chloride 0.5%, acetic acid chlorhexidine
0.6%th, deionized water surplus.
8 wound healing animal experiment of embodiment
1. experimental method
SD rat 160-180g, cleaning grade are taken, half male and half female carries out modeling after a week in adaptability raising, and method is as follows：
With 1% ketalar solution intraperitoneal injection of anesthesia, dosage 3mL/kg.Local preserved skin, routine disinfection, rat back take diameter
For the circular incision 1 of 1cm, skin holostrome, subcutaneous fascia superficialis are cut off until muscle layer, artificially manufactures wound on the surface of a wound after hemostasis
Local infection and causing infects, the unclean environment rich in pathogenic bacteria is (including Escherichia coli, pseudomonas aeruginosa, golden yellow grape
Coccus, staphylococcus epidermis, Candida albicans, aspergillus niger, enterococcus faecalis, mycoplasma, Chlamydia and Amoeba).With oil
Yarn, dressing, adhesive tape are fixed, and are dismantled after 48h, see that wound has purulent secretion, has excrement stink person for modeling success.
2. grouping administration
Modeling success animal is divided into control group, 1 group for the treatment of, 2 groups for the treatment of, 3 groups for the treatment of, 4 groups for the treatment of, 5 groups for the treatment of, treatment
6 groups, treatment 7 groups, control 1 group, control 2 groups, every group 20.Each group rat is cleaned a wound using physiological saline, wraps up dressing.Its
Middle control group presses 140,000 U/kg intraperitoneal injections of Benzylpenicillin sodium salt.Treatment group is removed by 140,000 U/kg intraperitoneal injections of Benzylpenicillin sodium salt
Outside, using embodiment 1-7 and comparative example 1-2 debridements healing washing lotion, wound is gently cleaned after being dipped using cotton balls, daily in the morning, afternoon and evening
Respectively once.The debridement healing washing lotion that treatment 1-7 groups give embodiment 1-7 respectively is handled, and control 1-2 groups are given respectively to be compared
The debridement healing washing lotion of example 1-2 is handled.Upon administration the 7th, 14 day, calculate surface of a wound closed index, surface of a wound closed index
Calculation formula is：Surface of a wound closed index=(surface of a wound area/original surface of a wound area after 1- treatments) * 100%.
3. experimental result
Each group statistical result is as shown in the table.As can be seen from the table, the 7th, 14 day surface of a wound closed index for the treatment of group is more right
It is significantly improved according to group, wound infection can effectively be inhibited by illustrating the debridement healing washing lotion of the present invention, promoted wound healing, accelerated wound
Healing rate.
The surface of a wound closed index comparison in the 7th, 14 day after the treatment of 1 each group experimental animal of table
Note：Compared with the control group, * P<0.05, * * P<0.01.
9 sterilization test of embodiment
Strain：Staphylococcus aureus (ATCC 26003)；Pseudomonas aeruginosa (ATCC 15442)；Escherichia coli
(8099)；Candida albicans (ATCC 10231).
Bacteria suspension is prepared：With 35 DEG C of YEPD fluid nutrient mediums culture 16 it is small when, activate twice, with blood cell counting plate meter
Number adjusts bacteria concentration to 1 × 10 with 1640 fluid nutrient mediums of RPM5~1 × 106A/mL.
Sterilization test：Taking bacteria suspension 1.0ml, the constant temperature in 19-21 DEG C of water-bath adds 4.0ml realities in sterile test tube
Apply the debridement healing washing lotion of the preparation of example 1, mixing, as test group.After acting on 60min, bacterium medicine mixed liquor 0.5ml and 4.5ml are taken
Mixing in neutralizer takes after neutralization 10min the liquid or dilution 1.0ml to be inoculated with sterile petri dish, pours into ordinary nutritional fine jade
Fat culture medium, in 37 DEG C of incubator culture 48h, observation is as a result, asepsis growth continued culture to the 7th day.
2 sterilization test of table
| Group | Staphylococcus aureus | Pseudomonas aeruginosa | Escherichia coli | Candida albicans |
| Control group | + | + | + | + |
| Test group | — | — | — | — |
Note：If culture dish is muddy, bacterium growth is indicated, for the positive, be denoted as (+).If the 7th day still clarifies, it is considered as sterile life
It is long, for feminine gender, it is denoted as (-).
Result of the test shows that debridement healing washing lotion antibacterial tests prepared by embodiment 1 are feminine gender, are killed to numerical value >=5, tool
There are great broad-spectrum antibacterial, bactericidal effect.
10 skin irritation of embodiment is evaluated
New zealand rabbit 3 is taken, conventinal breeding, 1 day hair by center back region shaves before experiment, and it is big to reject region
Small about 10cm × 10cm, gently scratches epidermis with the scissors sterilized, causes slight oozing of blood.The debridement healing of Example 1
Washing lotion 1ml is dropped on the hospital gauze of 5cm × 5cm sizes, as test group；Drop is had into a 0.5ml sterile waters, size for 5cm ×
5cm hospital gauzes are as a control group.Test group and control group gauze are attached to experimental animal respectively and pick hair-fields domain, medical adhesive tape is solid
It is fixed.After applying 4h, gauze is removed, is cleaned and dried with warm water, remove residual sample.
Remove the 1h after gauze, for 24 hours, 48h and 72h observe the dermoreaction of shaving region respectively, count shaving area skin
Erythema and oedema situation.Scores of erythema：No erythema 0 is divided, pole slight erythema 1 is divided, clear erythema 2 is divided, moderate erythema 3 is divided, severe
Erythema 4 is divided.Oedema scores：No oedema 0 is divided, extremely slight oedema 1 is divided, clear oedema 2 is divided, area of edema is divided less than 1mm 3, oedema
Region is divided more than 1mm 4.
The score data measured is substituted into formula, calculates primary stimulus index.Primary stimulus index K=(A-B)/3.
Wherein A represent test group for 24 hours, the primary sexual stimulus of 48h, 72h the sum of scores；B represent control group for 24 hours, the primary sexual stimulus of 48h, 72h
The sum of score.It is denoted as extremely slightly, is denoted as when K is between 0.5-1.9 slightly, when K is situated between when primary stimulus index K is less than 0.4
Moderate is denoted as when 2-4.9, severe is denoted as when K is between 5-8.
The results show that test group and control animals within the observation period without erythema, without redness, test group and control group skin
Skin state no significant difference, primary stimulus index K=0 do not have found other abnormal conditions of skin part in the observation period.Therefore
The debridement healing washing lotion of the present invention has no stimulation to damaged skin.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the method for the present invention is not departed from, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (4)
- The washing lotion 1. a kind of debridement is healed, which is characterized in that the ingredient and content of the debridement healing washing lotion be：
- The washing lotion 2. debridement according to claim 1 is healed, which is characterized in that the ingredient and content of the debridement healing washing lotion For：
- A kind of 3. promotion wound healing pharmaceutical preparation, including sealing container, which is characterized in that encapsulation in the sealing container The debridement healing washing lotion having the right described in requirement 1, and the sealing container is not chemically reacted with debridement healing washing lotion ingredient.
- 4. application of the debridement healing washing lotion described in claim 1 in the drug for promoting wound healing is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810190525.4A CN108096276A (en) | 2018-03-08 | 2018-03-08 | A kind of debridement healing washing lotion and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810190525.4A CN108096276A (en) | 2018-03-08 | 2018-03-08 | A kind of debridement healing washing lotion and its application |
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| Publication Number | Publication Date |
|---|---|
| CN108096276A true CN108096276A (en) | 2018-06-01 |
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ID=62206022
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|---|---|---|---|
| CN201810190525.4A Pending CN108096276A (en) | 2018-03-08 | 2018-03-08 | A kind of debridement healing washing lotion and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
| CN113244264A (en) * | 2021-06-07 | 2021-08-13 | 青岛威巴克生物技术有限公司 | Novel protective agent for promoting healing of ulcer surface |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
| CN104382932A (en) * | 2014-10-28 | 2015-03-04 | 天津嘉氏堂科技有限公司 | Composition for treating wounds |
| CN106668062A (en) * | 2017-01-23 | 2017-05-17 | 丽睿客信息科技（北京）有限公司 | Medicinal composition, application of medicinal composition to preparation of medicament for wound healing, medical preparation and medical bandage |
| CN106860891A (en) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | A kind of benzalkonium bromide sodium choride irrigation and preparation method thereof |
-
2018
- 2018-03-08 CN CN201810190525.4A patent/CN108096276A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
| CN104382932A (en) * | 2014-10-28 | 2015-03-04 | 天津嘉氏堂科技有限公司 | Composition for treating wounds |
| CN106668062A (en) * | 2017-01-23 | 2017-05-17 | 丽睿客信息科技（北京）有限公司 | Medicinal composition, application of medicinal composition to preparation of medicament for wound healing, medical preparation and medical bandage |
| CN106860891A (en) * | 2017-03-01 | 2017-06-20 | 成都正康药业有限公司 | A kind of benzalkonium bromide sodium choride irrigation and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112957408A (en) * | 2021-02-08 | 2021-06-15 | 北京奇愈生物科技有限公司 | Antibacterial cream for promoting skin healing and preparation method thereof |
| CN113244264A (en) * | 2021-06-07 | 2021-08-13 | 青岛威巴克生物技术有限公司 | Novel protective agent for promoting healing of ulcer surface |
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Application publication date: 20180601 |