CN108056778A - Biological sensor electrode elastic force type implanted device and its application method - Google Patents
Biological sensor electrode elastic force type implanted device and its application method Download PDFInfo
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- CN108056778A CN108056778A CN201610985667.0A CN201610985667A CN108056778A CN 108056778 A CN108056778 A CN 108056778A CN 201610985667 A CN201610985667 A CN 201610985667A CN 108056778 A CN108056778 A CN 108056778A
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- sensor electrode
- elastic force
- hollow
- pin
- puncture needle
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- 238000000034 method Methods 0.000 title claims abstract description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 39
- 239000000741 silica gel Substances 0.000 claims description 39
- 229910002027 silica gel Inorganic materials 0.000 claims description 39
- 238000002513 implantation Methods 0.000 claims description 19
- 238000005452 bending Methods 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 239000004745 nonwoven fabric Substances 0.000 claims description 5
- 239000011505 plaster Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000000717 retained effect Effects 0.000 claims description 4
- 238000004026 adhesive bonding Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 235000015110 jellies Nutrition 0.000 claims description 3
- 239000008274 jelly Substances 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 238000004064 recycling Methods 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 15
- 239000008103 glucose Substances 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 10
- 238000007920 subcutaneous administration Methods 0.000 description 10
- 206010033675 panniculitis Diseases 0.000 description 9
- 210000004304 subcutaneous tissue Anatomy 0.000 description 9
- 238000003780 insertion Methods 0.000 description 8
- 230000037431 insertion Effects 0.000 description 8
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 238000010586 diagram Methods 0.000 description 7
- 229910001220 stainless steel Inorganic materials 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 210000003811 finger Anatomy 0.000 description 4
- 210000004247 hand Anatomy 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 238000004078 waterproofing Methods 0.000 description 2
- 206010013082 Discomfort Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- PCLURTMBFDTLSK-UHFFFAOYSA-N nickel platinum Chemical compound [Ni].[Pt] PCLURTMBFDTLSK-UHFFFAOYSA-N 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
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- 230000008054 signal transmission Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
- A61B5/6849—Needles in combination with a needle set
Abstract
A kind of biological sensor electrode elastic force type implanted device and its method, including：Shell (10), it is axially set in shell (10), it is fixed on the hollow guide pin of positioning seat (1), it is fixed on Paracentesis needle holder (4), coaxial sleeve is arranged in hollow guide pin (2) the hollow puncture needle (3) for making smoothly to move, biosensor is mounted in hollow puncture needle Inner Front End, puncture needle is followed to move together, it is arranged at Paracentesis needle holder (4) rear, it is fixed on pipe of pushing pin (6), it is inserted into hollow puncture needle and punctures pushing pin (5) for coaxial needle with hollow, it is arranged at the pipe lid (7) of pushing pin of pipe of pushing pin (6) rear end, the end of biosensor in hollow puncture needle forms 10 15 degree of dog-ears.The present invention realizes automatic puncturing using assembled casing, elastic force type mechanism and specific force structure is punctured, and facilitates the novel sensor implanted device of recycling.The usability and security for making product are greatly improved.
Description
Technical field
The present invention relates to a kind of biosensor and its application method, in particular it relates to a kind of bio-sensing
Device electrode is implanted into subcutaneous elastic force type implanted device and its application method, and the biological sensor electrode is disposable with that can abandon
The needle-shaped bio-sensing pin of capillary or silk.
Background technology
The disease of some physiologicals, the course of disease is long and protracted inflammation is not more, it is necessary to carry out the long-term prison of physiological parameter constantly
It surveys, with the better tracing management of energy.For example diabetes, it is necessary to carry out monitoring constantly to blood glucose, diabetic uses at present
Most common to refer to blood blood glucose meter, patient needs voluntarily to gather finger peripheral blood to measure the blood glucose level of time point at that time.But this
It is not knowing the blood glucose level variation between measurement twice during kind the defects of point data, can not more obtains patient sleeps' phase
Between blood glucose level (hypoglycemia and the fluctuation of blood glucose flood tide be frequently experienced in sleep during), this causes very big to diabetic
Puzzlement.To solve the problems, such as these puzzlements, it is necessary to which a method for being capable of providing continuous blood sugar monitoring, makes patient know at any time certainly
Own blood glucose condition, and when finding the rule of change of blood sugar, taking measures in time, can most effectively symptom management, prevent simultaneously
Disease is sent out, obtains higher quality of life.
Continuous blood sugar instrument is then by the sensor electrode of a piercing subcutaneous tissue, in interstitial fluid and the internal Portugal of patient
Grape sugar occurs to form electric signal during oxidation reaction, and electric signal is converted into glucose readings therewith, leads to every 1-5 minutes glucose readings
It crosses transmitter to be transmitted on wireless receiver, and forms figure and popularize relevant blood glucose level data, referred to for patient and doctor.
At present, the glucose current type sensor of Endermic implantating, generally use very thin wire or polymer
Thin slice is carrier.Wire can apply the stainless steel wire of platinum with formula, for example, have document disclose using a diameter of 0.16~
Carrier of the stainless steel wire electroplated on top platinum of 0.25mm as sensor electrode.
Since the hardness of stainless steel wire is enough, sensor electrode can not puncture skin by auxiliary tool and enter in tissue.
But for the method for implantation since sensor electrode is larger, hardness is larger, so causing wound larger, pain sense is stronger, and implantation is subcutaneous
Afterwards there are sense or abnormal sense are stronger, testee receives willingness not strong.Manually there is implantation every time in implantation simultaneously
What is acted is inconsistent, does not confirm that factor increase falls to cause the increase of sensor bias value.
In addition, when wire carrier using softer platinum wire either apply platinum nickel wire etc. or using
When polymer flake is carrier, due to the rigidity deficiency of carrier, it is impossible to Direct perforantes skin.It is involved to need by auxiliary
The sensor electrode that assistant engineer has implantation subcutaneous tissue be using tiny platinum wire as carrier, with reduce implantation it is subcutaneous after exist sense or
Abnormal sense.
For this purpose, this field is needed tiny, soft biological sensor electrode implantation subcutaneously, puncture tube is at a terrific speed
Penetrate subcutaneous, pain sense allowed to drop to extremely low, and sensor electrode is stayed in subcutaneously, implantation act all in the pipeline of setting into
Row, reduces the deviation risk that manual operation is brought.
The content of the invention
To solve the above problems, it is an object of the present invention to provide a kind of biosensors to be implanted into the subcutaneous elastic force of human body
Formula implanted device and its application method, the biosensor are implanted into the subcutaneous elastic force type implanted device of human body and its application method
While solving the problems, such as to be not easy to be implanted into subcutaneous by tiny, soft biosensor, the area of wound is reduced, is alleviated
The pain sense of subcutaneous tissue is punctured, reduces the deviation risk problem that manual operation is brought.
In addition, another purpose for the elastic force type implanted device that aiding sensors electrode of the present invention punctures is：Solution will plant
The sensor electrode entered is connected the connection method of circuit with external electrical.Due to its tiny, soft characteristic, it is impossible to using conventional
Method as weld mode sensor electrode is effectively connected with electric signal transducer or transmitter because weld general
High temperature, which can be generated, causes the biology on sensor electrode to lose activity, and makes the distortion of sensor electrode performance or failure.
It is effectively connected to reach with electric signal transducer or transmitter progress without influencing its performance, the present invention will plant
The electric signal transmission of the sensor electrode entered employs transmission medium of the conductive rubber as electric signal, and sensor electrode needs are worn
It crosses conductive rubber to combine closely with conductive rubber, destructive action or measure need not be applied to sensor electrode, so as to have
The validity of the protection sensor electrode of effect.
According to the present invention, it is necessary to which the sensor electrode of implantation by the soft platinum wire carrier of a gold will be more with insulating layer
A electrode, which is separated, to be come, and is realized and is included at least a working electrode and a reference electrode, the platinum wire Carrier diameters
Extremely tiny, soft for 0.12mm, without the performance for penetrating skin, there are one subcutaneous for the design of above-mentioned sensor electrode
The sensing region of glucose in tissue fluid, for detecting sensor electricity of the analyte for the glucose in subcutaneous tissue liquid
Pole, sensing region is required to be implanted in subcutaneous tissue, thus requires sensing region that cannot stop in the dermis, can not
It is implanted in muscle.
It is covered in the sensing region of above-mentioned sensor electrode in a floor height molecular material and analyzed subcutaneous tissue liquid
Glucose into theory of evolution react, and will generate a raw electrical signal that can be detected by electronic component, through conductive matchmaker
Jie passes to electric signal transducer or transmitter carries out signal identification conversion, re-sends to receiver or corresponding APP supplies medical care
Professional person or patient read.Above-mentioned sensor electrode is, it is necessary to which sensor is electric using conductive rubber as transmission medium
The working electrode and reference electrode of pole combine closely respectively with conductive rubber to be formed one it is good contact, and mutually insulated is not
Conducting, and it is typically to be worn on the positions such as arm, belly, thigh to need the sensor electrode being implanted into, in continuous donning process
It inevitably to be contacted with water, working electrode and reference electrode are must be prevented from when being contacted with water and turns on to form one by water
Circuit causes sensor electrode to fail.
In order to achieve the above objectives, the technical solution of biological sensor electrode elastic force type implanted device of the invention is as follows：
A kind of biological sensor electrode elastic force type implanted device, including：
Shell 10,
In use, the positioning seat 1 combined with sensor base 101,
The hollow guide pin 2 of positioning seat 1 is axially set in shell 10, is fixed on,
Be provided with the knob that hollow puncture needle is promoted to be moved in hollow guide pin and
Paracentesis needle holder 4 is fixed on, hollow 2 internal clearance of guide pin cooperation is sheathed on, makees the hollow puncture needle 3 smoothly moved,
It is characterized in that,
The sensor base 101 set can the rotation seat 102 that rotates of tilted upward,
The silica gel seat 103 for set on the rotation seat and be used for the hollow guide pin 2 of drawing-in, being built-in with conductive rubber 104,
Biological sensor electrode 105 is mounted in hollow puncture needle Inner Front End, and hollow puncture needle is followed to move together,
Positioned at 4 rear of Paracentesis needle holder, it is arranged on pushing pin for 6 rear end of pipe of pushing pin and pushes pin 5 on pipe lid 7,
Push pin the hollow puncture needle of 5 insertions, for biological sensor electrode 105 in hollow puncture needle to be promoted to move forward,
Spring 9 is arranged with outside the connecting rod 8 between pipe lid 7 and Paracentesis needle holder 4 of pushing pin.
According to the present invention, the silica gel seat is used to install conductive rubber and carries out waterproofing protection to conductive rubber.When leading
When passing through silica gel seat and the conductive rubber being assemblied on silica gel seat to pin, silica gel seat and conductive rubber is caused to expand crimp,
After sensor electrode implantation is completed, when being packed into electric signal transducer or transmitter, while pressure can be applied to silica gel seat, to obtain
A space for one closing of conductive rubber is obtained, realizes the waterproof to conductive rubber.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that
End 2~3mm of the sensor electrode in hollow puncture needle, i.e., during rear end forms one relatively in hollow puncture needle
The bending of empty puncture needle axial direction 10-15 degree so that this bending part is worn with hollow when biosensor is placed in hollow puncture needle
Pricker inner wall generates a frictional force, is not slided so that biosensor is maintained at when not stressing and promoting in hollow puncture needle
It is de-.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that on silica gel seat 103
Side is provided with to install the assembling blind hole 1031 of conductive rubber 104, and 103 downside of silica gel seat is provided with to discharge conduction
Releasing for 104 strain energy of distortion of rubber can blind hole 1032.
According to the present invention, conductive rubber is embedded at column or block elastically deformable in assembling blind hole.
Since the electric conductivity of conductive rubber is determined by the data of the conducting particles of the unit sizes of conductive rubber, when
Its electric conductivity is with change after conductive rubber deformation, and the raw electrical signal that sensor electrode is implanted into is caused to generate deviation and distortion.
In order to obtain true and reliable electric signal, conductive rubber be provided with release strain energy of distortion hole the deformation of conductive rubber is allowed to become can
Control.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that exited in puncture needle
After silica gel seat, silica gel seat follows rotation seat to rotate fitting parallel with sensor base bottom surface so that sensor and/or transmitter
It is built-in wherein.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that the rotation seat
102 bottoms are provided with pivot pin 1021, and sensor base is internally provided with a pair of corresponding shaft bayonet 1014, the rotation seat bottom
The pivot pin 1021 in portion is caught in a pair of corresponding shaft bayonet 1014 of sensor base so that rotation seat can tilted upward rotationally
It is assemblied in sensor base.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that the rotation seat
Variable v notch v 1023 is provided among bottom pivot pin 1021, it is right to be caught in sensor base a pair for pivot pin when the rotation seat both sides
During the shaft bayonet answered, the position of rotation seat both sides pivot pin will generate crimp to the center of rotation seat, become v notch v 1023
The releasable crimp of setting pressure, the pivot pin 1021 of rotation seat is allow smoothly to be caught in shaft inside sensor base
Bayonet 1014.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that the rotation seat
103 upper ends are provided with the location hole that hollow guide pin 2 is guided accurately to pass through silica gel seat 103,
It sets in sensor base 101 for the positioning key 1012 that positions the bottom plate of positioning seat 1 and for by positioning seat
Bottom plate makees the Elastic buckle 1013 that elasticity blocks locking, is extracted after being easy to use.
When shell 10 is fixed in sensor base 101, shell is inserted into the positioning pipe of positioning seat 1, while positioning seat
Positioning port be caught in the positioning key 1012 of sensor base, position positioning seat 1, positioning seat bottom plate then passed through into sensor base
The Elastic buckle 1013 of setting is caught in sensor base 101, forms flexible fastening connection.
According to the present invention, rotation seat upper end sets location hole, and guiding guide pin accurately passes through silica gel seat.Rotation seat is also set
It is equipped with to install recessed (card) slot of silica gel seat, is caught in recessed (card) slot using the elasticity of silica gel seat, while is pressed on rotation seat.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that the puncture needle
Seat stretches out casing part and sets there are two knob 402, and knob is movably caught in the guide groove (1002) of shell,
It is separately provided for shake hands to move into the spacing bayonet positioned in it in the upper end of guide groove and centre
(1004),
The Paracentesis needle holder moves down under the elastic force effect of spring, is moved up in manual-up pulling knob.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that
Connecting rod 8 is additionally provided in shell 10,
Described 8 one end of connecting rod is inserted in pipe lid 7 of pushing pin, and the other end is fixed on Paracentesis needle holder 4, and Paracentesis needle holder 4 is with pushing pin
Pipe 6 forms a flexible connection,
The Paracentesis needle holder 4 and pipe lid 7 of pushing pin are respectively arranged with two semicircle bayonets for plug connection bar 8, the company
Extension bar is two section semicircle connecting rod combinations.
According to the present invention, Paracentesis needle holder is fixed in the connecting rod, lower end, and the semicircle card for pipe lower face of pushing pin is inserted into upper end
Mouthful, the semicircle bayonet clearance fit of connecting rod upper end and pipe lower face of pushing pin, connecting rod will be in the semicircle of pipe lower face of pushing pin
It is slided in bayonet, Paracentesis needle holder forms one with pipe of pushing pin and is flexibly connected.
The Paracentesis needle holder is provided with spring clamping boss 601, i.e. annular projection, in pipe lid 7 and the Paracentesis needle holder of pushing pin
Between connecting rod outside be arranged with spring.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that the sensor
Pedestal 101 has a non-woven fabrics adhesive plaster using ultrasonic bonding or sticky jelly gluing, and the bottom surface of sensor base is provided with ventilative
Hole 1011.
As a result, sensor base by non-woven fabrics adhesive plaster but be not limited to non-woven fabrics adhesive plaster holding be continuously attached to skin within more days
On, the bottom surface of sensor base is provided with air hole, ventilative to be pasted with the realization of the skin of sensor base, reduces due to not
It is ventilative to cause the allergy of skin or other discomforts.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that
The pipe peripheral side of pushing pin is correspondingly arranged on two and guides the gib block that pipe is moved up and down along outer casing inner wall of pushing pin
(201), gib block passes through the gib block through hole of outer casing top surface and guiding slot port (202) so that pipe of pushing pin is formed smoothly with shell
It is mobile to set.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that
Using internal diameter 0.5, the needle tubing of outer diameter 0.6, the inner and outer diameter of needle tubing do not limit the hollow guiding needle tubing, can be with
Suitable diameter is chosen according to the hollow puncture needle of insertion.Hollow guide pin and hollow puncture needle clearance fit.
According to the present invention, the sensor electrode surface for needing to be implanted into is covered with one layer of macromolecule membranous layer, is implanted into subcutaneous group
Reaction is generated with analyzed tissue form electric signal when knitting, and the abrasion of film layer is it is possible that increase the inclined of sensor electrode electric signal
Sensor electrode is placed in hollow puncture needle tubing by difference, and puncture needle tube shape with sky coordinates into a limit, when reducing lancing motion
The abrasion of sensor electrode.
It is preferred according the present invention, that the hollow guide pin uses the stainless steel material of inside and outside light knot but is not limited to
Stainless steel material can be other metallic hard materials.
It is preferred according the present invention, that the hollow puncture needle tubing is using internal diameter 0.35, the needle tubing of outer diameter 0.45.
It is preferred according the present invention, that it is described push pin select outer diameter 0.3mm shanks, but be not limited to 0.3mm can root puncture pin
Pipe selects.
It is preferred according the present invention, that the hollow guide pin is fixed on inside positioning seat, hollow guide pin and positioning seat
Bottom surface is into the angle of 35-45 degree.
This angle allows puncture needle to be more easy to penetrate skin tissue, and mitigates patient pain and the damage to tissue, improve puncture into
Power.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that described to push pin under pipe
Portion is equipped with clamping boss (601), i.e. annular protrusion inner ring, and for carrying out /V to pipe of pushing pin, the /V is pushed into skin according to palpus
Depending on the biosensor of skin.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that the pipe of pushing pin
It in the top of Paracentesis needle holder, is connected with Paracentesis needle holder by connecting rod, on the shell, pipe lower end of pushing pin is set for the company of connection for assembling
The semicircle bayonet of extension bar is provided with buckle in the top surface for pipe of pushing pin, and pipe of pushing pin passes through the top surface of shell, and pipe lid is combined with pushing pin,
The push pin buckle of pipe of bayonet lock insertion that the pipe of pushing pin covers setting is fixedly connected with pipe of pushing pin.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, it is preferred that
The Paracentesis needle holder stretches out casing part and sets there are two knob 402, and knob is movably caught in the guiding of shell
Slot (1002),
It is separately provided for shake hands to move into the spacing bayonet positioned in it in the upper end of guide groove and centre
(1004),
The Paracentesis needle holder moves down under the elastic force effect of spring, is moved up in manual-up pulling knob.
According to the present invention, the guide groove of Paracentesis needle holder can be caught in spacing bayonet, under no outer masterpiece power, spacing bayonet
It will keep Paracentesis needle holder guide groove that cannot be slipped in spacing bayonet.
According to the present invention, the handle of Paracentesis needle holder is pulled, Paracentesis needle holder is moved into Paracentesis needle holder to the top surface of shell, is punctured
The guide groove of needle stand is caught in the spacing bayonet of shell when the guide groove of shell runs to top again, and spring-compressed is generated elastic force
And store, when Paracentesis needle holder guide groove depart from shell spacing bayonet when, compression spring release elastic force by Paracentesis needle holder to
Lower promotion.
A kind of biological sensor electrode elastic force type implanted device according to the present invention, which is characterized in that puncture needle is in
Setting in empty guide pin 2 causes the puncture needle when in use, and puncture needle pinpoint inclined plane is upward.
The present invention provides a kind of elastic force type method for implantation of biological sensor electrode again, which is characterized in that uses the life
Object sensor electrode elastic force type implanted device, it would be desirable to the sensor electrode of implantation is placed in a hollow puncture needle, with
Puncture needle spikes through conductive rubber together and its component is used, and then puncture needle exits conductive rubber, while is pushing pin
Under the action of, the sensing area end of sensor electrode is retained in region to be measured, and the other end is retained in inside conductive rubber.
The elastic force type method for implantation of a kind of sensor electrode according to the present invention, which is characterized in that conductive rubber is installed
Loaded onto in silica gel seat, an oppressive force apply silica gel seat by electric signal transducer or transmitter, silica gel itself it is deformable
Elasticity makes glue silicon seat turn on binding face with electric signal transducer or transmitter to fit closely to form a sealing space, prevent water
Contact conductive rubber.
Described according to the present invention, setting of the puncture needle in hollow guide pin 2 causes the puncture needle when in use, punctures
Pin pinpoint inclined plane is upward.
The biosensor is a needle-shaped or Filamentous made of metal biosensor.Preferably, the hollow guide pin
Using inside and outside bright and clean stainless steel material so that puncture needle is in hollow guide pin.
Preferably, hollow guide pin and positioning seat bottom surface are into 40 degree of angle.
Puncture needle is more easy to penetrate skin tissue as a result, and mitigates patient pain and the damage to tissue, and raising punctures successfully
Rate.
In addition, hollow guide pin is loaded on biosensor pedestal simultaneously, the silica gel seat that biosensor dress is held is had passed through
And conductive rubber, it avoids puncture needle and is contacted with the silica gel seat and conductive rubber of biosensor, when avoiding lancet puncture
Silica gel, conductive rubber are brought into and subcutaneously organize thin risk.
Description of the drawings
Figure 1A, Figure 1B are the elastic force type implanted device structural upright schematic diagram of the present invention respectively.
Fig. 2 is the elastic force type implanted device part exploded perspective view of the present invention.
Fig. 3,4 be the elastic force type implanted device Paracentesis needle holder schematic diagram of the present invention respectively.
Fig. 5,6 be that the elastic force type implanted device biosensor of the present invention is pushed pin pipe schematic diagram respectively.
The elastic force type implanted device biosensor that Fig. 7 is the present invention is pushed pin pipe lid schematic diagram.
Fig. 8,9 be the elastic force type implanted device biosensor base schematic diagram of the present invention respectively.
Figure 10,11 be the elastic force type implanted device silica gel seat schematic diagram of the present invention respectively.
Figure 12,13 be respectively the present invention elastic force type implanted device biosensor base bottom and shed showing for rotation seat
It is intended to.
Figure 14,15 be the elastic force type implanted device rotation seat schematic diagram of the present invention respectively.
Figure 16 is silica gel seat schematic cross-sectional view.
In figure：1 is positioning seat, and 2 be hollow guide pin, and 3 be hollow puncture needle, and 4 be Paracentesis needle holder, and 5 is push pin, and 6 be to push away
Needle tubing, 7 be pipe lid of pushing pin, and 8 be connecting rod, and 9 be spring, and 10 be shell, and 101 be sensor base.
201 be the raised gib block for being correspondingly arranged in pipe peripheral side of pushing pin, which can be part or discontinuously shape is convex
It rises, 202 be guiding slot port, and 1002 perforations are arranged at shell wall, for shaking hands puncture needle are driven to be moved up and down along shell wall
Guide groove, 1004 be to be arranged at the upper end of guide groove and middle part, the spacing bayonet for positioning of shaking hands, and 601 be pipe lower part of pushing pin
Clamping boss (spacing ring), 1001 be arranged at outer casing bottom periphery positioning fixations be buckled, 401 be arranged at puncture needle
The spring clamping boss of seat upper end, 402 be knob, and 403 are used to connect the semicircle bayonet of connecting rod for Paracentesis needle holder.603 be to push away
Needle tubing is used to connect the semicircle bayonet of connecting rod.
In figure：1011 air holes, 1012 positioning keys, 1013 Elastic buckles, 1014 shaft bayonets, 102 rotation seats, 1021 axis
Pin, 1022 location holes, 1023 become v notch vs, 1024 location holes, 103 silica gel seats, 1031 assembling blind holes, 1032 release can blind hole, 104
Conductive rubber, 105 sensor electrodes, 2001,2002 be respectively the positioning convex point with 1001 cooperation of 1012 positioning keys and buckle,
2003 positioning pipes, 602 feather keys, 801 spacing rings, 803 buckles, 901 be the bayonet lock of cooperation buckle 803.
Specific embodiment
Embodiment
Referring to Fig. 1, a kind of biological sensor electrode elastic force type implanted device, including：
Shell 10, in use, the positioning seat 1 combined with sensor base 101, is axially set in shell 10, is fixed on
The hollow guide pin 2 of positioning seat 1 is provided with the knob that hollow puncture needle is promoted to be moved in hollow guide pin and fixes
In Paracentesis needle holder 4, it is sheathed on hollow 2 internal clearance of guide pin cooperation, the hollow puncture needle 3 that work smoothly moves.
The sensor base 101 set can the rotation seat 102 that rotates of tilted upward, set to wear on the rotation seat
Through hollow guide pin 2, the silica gel seat 103 of conductive rubber 104 is built-in with, biological sensor electrode 105 is in hollow puncture needle
Front end follows hollow puncture needle to move together, positioned at 4 rear of Paracentesis needle holder, is arranged on the pushing pin on pipe lid 7 of 6 rear end of pipe of pushing pin
Push pin 5.Push pin the hollow puncture needle of 5 insertions, for biological sensor electrode 105 in hollow puncture needle to be promoted to move forward, pipe of pushing pin
Spring 9 is arranged with outside connecting rod 8 between lid 7 and Paracentesis needle holder 4.The sensor base 101 using ultrasonic bonding or
Sticky jelly gluing has non-woven fabrics adhesive plaster, and the bottom surface of sensor base is provided with air hole 1011.
Positioning seat bottom plate front end bayonet insertion sensor base, rear end press-in sensor base can be in sensor base
Positioning seat bottom plate is then blocked locking by the bayonet of deformation, is also secured to the hollow guide pin inside positioning seat and is passed through bio-sensing
The dress of device holds silica gel seat, conductive rubber, and the angle with bottom surface angle is 40 degree.
According to the present embodiment, 102 bottom of rotation seat is provided with pivot pin 1021, and sensor base is internally provided with a pair
Corresponding shaft bayonet 1014, the pivot pin 1021 of the rotation seat bottom are caught in a pair of corresponding shaft bayonet of sensor base
In 1014 so that rotation seat can tilted upward be rotationally assemblied in sensor base.
According to the present embodiment, variable v notch v 1023 is provided among rotation seat bottom pivot pin 1021, when described turn
When dynamic seat both sides pivot pin is caught in sensor base a pair corresponding shaft bayonet, the position of rotation seat both sides pivot pin will be to rotation seat
Center generate crimp, become the pressure of the releasable crimp of setting of v notch v 1023, make the pivot pin 1021 of rotation seat
The shaft bayonet 1014 that can be smoothly caught in inside sensor base.
Referring to Fig. 1 (4) Paracentesis needle holder, knob is provided with, spring clamping boss, semicircle bayonet, one end of (8) connecting rod is inserted
Enter the semicircle bayonet 403 of (4) Paracentesis needle holder, the other end insertion of (8) connecting rod push pin pipe semicircle bayonet 603 in, will be in wearing
Pricker seat forms one with pipe of pushing pin and is flexibly connected, and (6) pipe of pushing pin is flexibly connected by connecting rod with Paracentesis needle holder, is pushed pin simultaneously
Pipe is pushed pin in the hollow puncture needle of insertion, and (9) spring is put into one end top in (10) shell and, to the inner top surface of shell, (4) is punctured
Needle stand is packed into shell together with (6) pipe of pushing pin, and the knob of Paracentesis needle holder is caught in the locating slot of shell, the insertion of spring clamping boss
Paracentesis needle holder is led to after compression spring the bayonet for the top for being caught in shell by spring, and (6) push pin pipe upper end through outer casing top surface simultaneously
Through hole, pipe both sides gib block of pushing pin passes through from the notch of outer casing top surface, then (7) pipe lid of pushing pin is caught in (6) pipe of pushing pin and is fixed
Connection.Biosensor is packed into hollow puncture needle, and the card slot that shell lower end is caught in positioning seat forms a fixed connection.
When need to biosensor be implanted into subcutaneous tissue referring to Fig. 1, the knob on (4) Paracentesis needle holder, Paracentesis needle holder are turned
The bayonet for deviating from the top of shell enters the guide groove of shell, under (9) tension force of spring, puncture needle, Paracentesis needle holder, push pin,
Pipe of pushing pin quickly moves together, and puncture needle quick puncture subcutaneous tissue allows pain sense to be preferably minimized, female when puncture needle is extracted
Finger presses pipe lid of pushing pin, and forefinger, middle finger hold the knob of Paracentesis needle holder toward pull-up, and the under bayonet until being caught in shell punctures
Pin above carries very much, and pushes pin to be lived by female finger pressure, and pushing pin prevents biosensor to be moved upwardly together with puncture needle, so as to be implanted into skin
Under.
According to the present embodiment, the silica gel seat is used to install conductive rubber and carries out waterproofing protection to conductive rubber.When
When guide pin is through silica gel seat and the conductive rubber being assemblied on silica gel seat, silica gel seat and conductive rubber is caused to expand to squeeze and become
Shape after sensor electrode implantation is completed, when being packed into electric signal transducer or transmitter, while can apply pressure to silica gel seat,
To obtain a space for one closing of conductive rubber, the waterproof to conductive rubber is realized.
According to the present embodiment, end 3mm of the sensor electrode in hollow puncture needle, i.e., rear end is formed in hollow puncture needle
The bending of one opposite hollow puncture needle axial direction 13-15 degree so that biosensor places this bending part when in hollow puncture needle
Divide and generate a frictional force with hollow puncture needle inner wall, so that biosensor is maintained at hollow puncture when not stressing and promoting
It is not slipped in pin.The hollow puncture needle tubing uses internal diameter 0.35, the inside and outside bright and clean stainless steel material needle tubing of outer diameter 0.45,
Described push pin selects outer diameter 0.3mm shanks, and setting of the puncture needle in hollow guide pin 2 causes the puncture needle when in use,
Upward, hollow guide pin and positioning seat bottom surface are into 40 degree of angle for puncture needle pinpoint inclined plane.
After puncture needle exits silica gel seat, silica gel seat follows rotation seat to rotate fitting parallel with sensor base bottom surface,
So that sensor and/or transmitter are embedding wherein.
A kind of biological sensor electrode elastic force type implanted device according to the present invention and its method, solving will be tiny, soft
Soft biosensor is not easy to be implanted into the problem of subcutaneous, and reduces the area of wound, alleviates the pain for puncturing subcutaneous tissue
Sense, reduces the deviation risk problem that manual operation is brought.
Claims (13)
1. a kind of biological sensor electrode elastic force type implanted device, including：
Shell (10),
In use, the positioning seat (1) combined with sensor base (101),
The hollow guide pin (2) of positioning seat (1) is axially set in shell (10), is fixed on,
Be provided with the knob that hollow puncture needle is promoted to be moved in hollow guide pin and
Paracentesis needle holder (4) is fixed on, the cooperation of hollow guide pin (2) internal clearance is sheathed on, makees the hollow puncture needle smoothly moved
(3),
It is characterized in that,
The sensor base (101) set can the rotation seat (102) that rotates of tilted upward,
The silica gel seat (103) for set on the rotation seat and be used for the hollow guide pin of drawing-in (2), being built-in with conductive rubber (104),
Biological sensor electrode (105) is mounted in hollow puncture needle Inner Front End, and hollow puncture needle is followed to move together,
Positioned at Paracentesis needle holder (4) rear, push pin (5) pushed pin on pipe lid (7) of pipe of pushing pin (6) rear end are arranged on,
Push pin (5) be inserted into hollow puncture needle, for biological sensor electrode (105) in hollow puncture needle to be promoted to move forward,
Spring (9) is arranged with outside the connecting rod (8) between pipe lid (7) and Paracentesis needle holder (4) of pushing pin.
A kind of 2. biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that sensor electrode
(105) 2~3mm of end in hollow puncture needle (3), i.e., rear end forms an opposite hollow and punctures needle shaft in hollow puncture needle
Bending to 10-15 degree so that this bending part is worn with hollow when biological sensor electrode (105) is positioned in hollow puncture needle
Pricker inner wall generates a frictional force, so that biological sensor electrode (105) is maintained at hollow puncture when not stressing and promoting
It is not slipped in pin.
A kind of 3. biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that silica gel seat (103)
Upper side is provided with to install the assembling blind hole (1031) of conductive rubber (104), and silica gel seat (103) downside, which is provided with, to be used for
Releasing for release conductive rubber (104) strain energy of distortion can blind hole (1032).
A kind of 4. biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that the rotation seat
(102) bottom is provided with pivot pin (1021), and sensor base is internally provided with a pair of corresponding shaft bayonet (1014), described turn
The pivot pin (1021) of dynamic seat bottom is caught in a pair of corresponding shaft bayonet (1014) of sensor base so that rotation seat can be upper and lower
It is assemblied in sensor base tilt rotation.
A kind of 5. biological sensor electrode elastic force type implanted device as claimed in claim 4, which is characterized in that the rotation seat bottom
Variable v notch v (1023) is provided among portion's pivot pin (1021), pivot pin is caught in sensor base a pair when the rotation seat both sides
During corresponding shaft bayonet, the position of rotation seat both sides pivot pin will generate crimp to the center of rotation seat, become v notch v
(1023) pressure of the releasable crimp of setting, makes the pivot pin (1021) of rotation seat can smoothly be caught in sensor base
The shaft bayonet (1014) in portion.
A kind of 6. biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that the rotation seat
(103) upper end is provided with the location hole that hollow guide pin (2) is guided accurately to pass through silica gel seat (103),
The positioning key (1012) that the bottom plate of positioning seat (1) is positioned is set in sensor base (101) and for that will position
Seat bottom plate makees the Elastic buckle (1013) that elasticity blocks locking, is extracted after being easy to use.
7. a kind of biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that
The Paracentesis needle holder stretches out casing part and sets there are two knob (402), and knob is movably caught in the guide groove of shell
(1002),
It is separately provided for shake hands to move into the spacing bayonet (1004) positioned in it in the upper end of guide groove and centre,
The Paracentesis needle holder moves down under the elastic force effect of spring, is moved up in manual-up pulling knob.
8. a kind of biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that
Connecting rod (8) is additionally provided in shell (10),
Described connecting rod (8) one end is inserted in pipe lid (7) of pushing pin, and the other end is fixed on Paracentesis needle holder (4), Paracentesis needle holder (4) with
Pipe (6) of pushing pin forms a flexible connection,
The Paracentesis needle holder (4) and pipe lid (7) of pushing pin are respectively arranged with two semicircle bayonets for plug connection bar (8), described
Connecting rod is two section semicircle connecting rod combinations.
A kind of 9. biological sensor electrode elastic force type implanted device as described in claim 1, which is characterized in that the sensor bottom
Seat (101) has a non-woven fabrics adhesive plaster using ultrasonic bonding or sticky jelly gluing, and the bottom surface of sensor base is provided with ventilative
Hole (1011).
A kind of 10. elastic force type method for implantation of biological sensor electrode, which is characterized in that any one of usage right requirement 1-9 institutes
State biological sensor electrode elastic force type implanted device, it would be desirable to which the sensor electrode of implantation is placed on a hollow puncture needle
In, conductive rubber is spiked through together with puncture needle and its component is used, then puncture needle exits conductive rubber, while
Under the action of pushing pin, the sensing area end of sensor electrode is retained in region to be measured, and the other end is retained in inside conductive rubber.
A kind of 11. elastic force type method for implantation of biological sensor electrode as claimed in claim 10, which is characterized in that conductive rubber
Loaded onto mounted on silica gel seat, an oppressive force apply silica gel seat by electric signal transducer or transmitter, silica gel itself can
Elastomeric deformable makes glue silicon seat turn on binding face with electric signal transducer or transmitter to fit closely to form a sealing space, prevent
Water contacts conductive rubber.
12. the elastic force type method for implantation of a kind of biological sensor electrode as claimed in claim 10, which is characterized in that puncture needle exists
Setting in hollow guide pin (2) causes the puncture needle when in use, and puncture needle pinpoint inclined plane is upward.
13. the elastic force type method for implantation of a kind of biological sensor electrode as claimed in claim 10, which is characterized in that pull and puncture
Paracentesis needle holder is moved Paracentesis needle holder by the handle of needle stand to the top surface of shell, and the guide groove of Paracentesis needle holder is in the guide groove of shell
The spacing bayonet of shell is caught in when running to top again, spring-compressed is generated into elastic force and is stored, when the guide groove of Paracentesis needle holder
When departing from the spacing bayonet of shell, the spring release elastic force of compression pushes down on Paracentesis needle holder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610985667.0A CN108056778A (en) | 2016-11-09 | 2016-11-09 | Biological sensor electrode elastic force type implanted device and its application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610985667.0A CN108056778A (en) | 2016-11-09 | 2016-11-09 | Biological sensor electrode elastic force type implanted device and its application method |
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| CN108056778A true CN108056778A (en) | 2018-05-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610985667.0A Pending CN108056778A (en) | 2016-11-09 | 2016-11-09 | Biological sensor electrode elastic force type implanted device and its application method |
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| CN112294302A (en) * | 2019-08-02 | 2021-02-02 | 华广生技股份有限公司 | Biosensor implanting device and implanting method thereof |
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