CN108048322A - Novel cell incubator, cell manipulation platform and its method of work - Google Patents
Novel cell incubator, cell manipulation platform and its method of work Download PDFInfo
- Publication number
- CN108048322A CN108048322A CN201711493009.0A CN201711493009A CN108048322A CN 108048322 A CN108048322 A CN 108048322A CN 201711493009 A CN201711493009 A CN 201711493009A CN 108048322 A CN108048322 A CN 108048322A
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- China
- Prior art keywords
- housing
- transfer member
- bracket
- opening
- table top
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/52—Mobile; Means for transporting the apparatus
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The present invention provides a kind of novel cell incubator, cell manipulation platform and its method of work using the cell incubator, novel cell incubator includes culture dish；Housing has opening；Guide rail is arranged in the housing；Transfer member is wound on the guide rail, and does circulatory motion under driving；At least two brackets, the bracket are fixed on the transfer member, bracket carrying at least two culture dishes；As the bracket of transfer member movement is gradually exposed to the opening；The part of separator is arranged in the region that the transfer member surrounds, and the in vivo space of the shell is divided into first portion and second portion.The present invention have many advantages, such as culture dish it is easy to change, place quantity it is more, replacement culture dish when need not extract the embedded incubator of culture dish frame, desktop out.
Description
Technical field
The present invention relates to cell culture, more particularly to novel cell incubator, cell manipulation platform and its method of work.
Background technology
At present, traditional cell incubator is wall-mounted that multistage card slot is set inside incubator, and card slot has guide rail,
Then and culture dish frame is drained into, that is, is divided into the culture dish frame that multilayer is mutually parallel.When needing to be put into culture dish, by culture dish
Frame is extracted out, is inserted culture dish, then is pushed back culture dish frame.When cultivating chamber door unlatching, all pallets and culture dish can be directly touched.
Such cell incubator mainly has following deficiency：
Because wall-mounted incubator is higher, to the inconvenient of pallet and culture dish；It needs to take out when replacing culture dish
Go out culture dish frame, culture dish is replaced inconvenient；When opening chamber door, gas concentration, humidity, temperature of cells survival etc. are suitble in case
Condition is easily affected.
The content of the invention
To solve the deficiency in above-mentioned prior art, the present invention provides a kind of culture dish is easy to change, culture dish
Placement quantity is more, need not extract the novel cell incubator of culture dish frame out.
The purpose of the present invention is what is be achieved through the following technical solutions：
A kind of novel cell incubator, the novel cell incubator include culture dish；The novel cell incubator into
One step includes：
Housing, the housing have opening；
Guide rail, the guide rail are arranged in the housing；
Transfer member, the transfer member are wound on the guide rail, and do circulatory motion under driving；
At least two brackets, the bracket are fixed on the transfer member, bracket carrying at least two culture dishes；With
The bracket of transfer member movement is gradually exposed to the opening；
Separator, the part of the separator is arranged in the region that the transfer member surrounds, and the shell is in vivo
Space is divided into first portion and second portion.
According to above-mentioned novel cell incubator, it is preferable that the guide rail is arc.
According to above-mentioned novel cell incubator, it is preferable that the guide rail is formed at rotating wheel.
According to above-mentioned novel cell incubator, it is preferable that the central axis upright of the transfer member of rotation is in rotation
The plane that bracket is formed, alternatively, the central axis upright of the transfer member rotated is in bracket.
According to above-mentioned novel cell incubator, it is preferable that the bracket is rotatably arranged in the biography by shaft
Send the side of component, the shaft and the centerline axis parallel.
According to above-mentioned novel cell incubator, in order to ensure the isolation in housing between first portion and second portion
The moving direction of transfer member can and be adapted to, the separator includes：
Fixed part；
Movable part, the movable part are separately positioned on the opposite both ends of the fixed part, and in fixed part
Divide between transfer member；The movable part has the bending part extended along the transfer member moving direction.
The present invention also aims to provide the cell manipulation platform using above-mentioned novel cell incubator, there is culture dish
Easy to change, culture dish places that quantity is more, need not extract culture dish frame out, is embedded in the advantages that above-mentioned novel cell incubator, the hair
Improving eyesight technical scheme is that：
According to the cell manipulation platform of above-mentioned novel cell incubator, the cell manipulation platform includes table top；The cell
Operation console further comprises：
Stent, the stent are arranged under the table top, have the first supporting item and the second supporting item on the stent,
During so that the first supporting item carrying the housing, the outlet carries the shell not less than the table top, second supporting item
During body, the outlet is not higher than the table top；
The opening separately set, the opening separately set is arranged on the table top, suitable for passing through for the housing.
According to above-mentioned cell manipulation platform, optionally, the cell manipulation platform further comprises：
Chamber door, the chamber door are arranged on the opening of the table top.
According to above-mentioned cell manipulation platform, it is preferable that the supporting item is hasp.
The present invention also aims to provide the method for work of above-mentioned cell manipulation platform, the goal of the invention be by with
What lower technical solution was achieved：
According to the method for work of above-mentioned cell manipulation platform, the method for work comprises the following steps：
(A1) housing is promoted, the second supporting item carries the housing so that the opening of housing is not less than the table top；
(A2) transfer member rotates in a ring on guide rail；
(A3) bracket corresponding with the culture dish selected is as the transfer member is mobile and opening exposed to the housing
At mouthful；
(A4) culture dish of selection is taken out；
(A5) housing declines, and the first supporting item carries the housing so that the opening of housing is not higher than the table top.
Compared with prior art, the device have the advantages that being：
1. culture dish is easy to change
The bracket of culture dish is carried as the rotation two of transfer member is gradually exposed to the opening of housing, people easy to operation
Member replaces the culture dish of selection, without extracting bracket out；When using motor drive transmission part, culture dish selection, training are realized
Support the automation of ware movement；
2. separator will isolate first portion and second portion in housing, cells survival environment is preferably protected, is had
More effectively maintain the conditions such as temperature, humidity, the gas concentration needed for cells survival；
3. the novel cell incubator of this patent is embedded into Table top type cell manipulation platform, operating handle than it is wall-mounted more
It is good.
Description of the drawings
Referring to the drawings, the disclosure will be easier to understand.Skilled addressee readily understands that be：This
A little attached drawings are used only for the technical solution illustrated the present invention, and are not intended to and protection scope of the present invention is construed as limiting.
In figure：
Fig. 1 is the structure diagram of novel cell incubator according to embodiments of the present invention；
Fig. 2 is the structure diagram of cell manipulation platform according to embodiments of the present invention.
Specific embodiment
Fig. 1-2 and following description describe the present invention optional embodiment to instruct how those skilled in the art implement
It is of the invention with reproducing.In order to instruct technical solution of the present invention, simplified or some conventional aspects be omitted.Those skilled in the art
It should be appreciated that modification or replacement from these embodiments will within the scope of the invention.Those skilled in the art should understand that
Following characteristics can combine to form multiple modifications of the present invention in various ways.As a result, the invention is not limited in it is following can
Embodiment is selected, and is only limited by the claims and their equivalents.
Embodiment 1：
Fig. 1 schematically illustrates the structure diagram of the novel cell incubator of the embodiment of the present invention 1, as shown in Figure 1, institute
Stating novel cell incubator includes：
Culture dish 12；
Housing 4, the housing have opening 13, as the position at top is faced in side；Hull outside has 10 grade branch of hasp
Support member；
Guide rail (not shown), the guide rail are arranged in the housing；Guide rail can be formed on rotating wheel, can also be
Several (such as 3,4) arc-shaped guide rails surround relative closure region；
Transfer member 11, the transfer member are wound on the guide rail, and are driven in (manpower or electric power or machine power)
Under do circulatory motion；
At least two brackets 9, the bracket are fixed on the transfer member, bracket carrying at least two culture dishes；With
The bracket for transfer member movement is gradually exposed to the opening so that operating personnel get the culture dish of its selection；
Separator 1-2,8, the part of the separator is arranged in the region that the transfer member surrounds, by the housing
Interior space is divided into first portion and second portion；
Humidity and gas concentration control unit, this is the state of the art, and details are not described herein.
In order to make the angle of culture dish relative level in transfer member rotation process constant, further, turn
The plane that the central axis upright of dynamic transfer member is formed in the bracket of rotation, alternatively, the center of the transfer member rotated
Axis is perpendicular to bracket.
In order to make the angle of culture dish relative level in transfer member rotation process constant, further, institute
State the side that bracket is rotatably arranged in the transfer member by shaft, the shaft and the centerline axis parallel.
In order to ensure the isolation performance in housing between first portion and second portion and adapt to the mobile side of transfer member
To further, the separator includes：
Fixed part 2；
Movable part 1,8, the movable part are separately positioned on the opposite both ends of the fixed part, and in fixation
Between part and transfer member；The movable part has the bending part extended along the transfer member moving direction.
Fig. 2 schematically illustrates the structure diagram of the cell manipulation platform of the embodiment of the present invention, as shown in Fig. 2, described thin
Born of the same parents' operation console includes：
Table top 17；
Stent 5, the stent are arranged under the table top, have the first supporting item and the second support on the stent
Part so that when the first supporting item 6 carries the housing 4, not less than the table top, second supporting item 20 carries for the outlet
During the housing, the outlet is not higher than the table top；
The opening separately set, the opening separately set is arranged on the table top, suitable for passing through for the housing.
In order to ensure the in vivo cleannes of shell, the cell manipulation platform further comprises：
Chamber door 16, the chamber door are arranged on the opening of the table top.
The method of work of the above-mentioned cell manipulation platform of the embodiment of the present invention, the method for work comprise the following steps：
(A1) housing is promoted, the second supporting item carries the housing so that the opening of housing is not less than the table top；
(A2) transfer member rotates in a ring on guide rail；
(A3) bracket corresponding with the culture dish selected is as the transfer member is mobile and opening exposed to the housing
At mouthful；
(A4) culture dish of selection is taken out；
(A5) housing declines, and the first supporting item carries the housing so that the opening of housing is not higher than the table top.
Embodiment 2：
According to embodiments of the present invention 1 novel cell incubator and its application examples of method of work.
In the application examples, as shown in Figs. 1-2, in cell incubator：Guide rail uses 4 rotating wheels, including 1 by motor
Driving wheel, 3 driven wheels of 7 drivings；Transfer member uses conveyer belt, is wound on 4 rotating wheel outer rims；8 brackets are equably (logical
Cross shaft) side of conveyer belt is fixed on, bracket is freely rotated in conveyer belt moving process, so that on bracket
The angle of culture dish relative level is constant, that is, doing the central axis of the conveyer belt of circulatory motion, (axis is parallel to rotation
The central axis of wheel) perpendicular to bracket；The position opening at top is faced in the side of housing；6 culture dishes are set on each bracket,
The correspondence of culture dish and bracket is recorded, there is number on each bracket；The outside portion of housing has hasp；Separator bag
It includes：The fixed part being vertically arranged；Movable part is separately positioned on the opposite top and bottom of the fixed part, and is in
Between fixed part and transfer member, can on fixed part 360 degree rotation, so as to adapt to the different moving directions of conveyer belt；
The movable part has the bending part extended along the transfer member moving direction, so as to be divided into left and right arrangement in housing
First portion and second portion.
In cell manipulation platform：There is the opening separately set, suitable for passing through for housing on table top；The opening separately set has case
There is hinge to be rotatably mounted on table top for door, chamber door；There is stent, for carrying the cell training of 1 or more under table top
Support case, specifically on stent have with matched first hasp of hasp of housing and the second hasp, when the second hasp and housing
It is snap-fitted when, the opening of housing is not less than table top；When the first hasp and housing it is snap-fitted when, the opening of housing is not high
In table top, if the top of housing is not higher than table top, chamber door；
The method of work of the above-mentioned cell manipulation platform of the embodiment of the present invention, the method for work comprise the following steps：
(A1) chamber door is opened, operating personnel promote corresponding cell incubator, and the second hasp carries the housing so that shell
The opening of body is not less than the table top；
(A2) under motor driving, conveyer belt rotates in a ring on rotating wheel；
(A3) bracket corresponding with the culture dish selected is as the conveyer belt is mobile and is exposed to the opening of the housing
Place, it is number by observing bracket to have so that is exposed to the opening of housing corresponding to the bracket of the culture dish of selection；
(A4) motor stops, and operating personnel take out the culture dish of selection；
(A5) operating personnel's mobile shell so that the first supporting item carries the housing so that the opening of housing is not higher than
Chamber door is closed in the table top, the top of housing less than chamber door position.
Claims (10)
1. a kind of novel cell incubator, the novel cell incubator includes culture dish；It is characterized in that：The novel cell
Incubator further comprises：
Housing, the housing have opening；
Guide rail, the guide rail are arranged in the housing；
Transfer member, the transfer member are wound on the guide rail, and do circulatory motion under driving；
At least two brackets, the bracket are fixed on the transfer member, bracket carrying at least two culture dishes；With transmission
The bracket of component movement is gradually exposed to the opening；
Separator, the part of the separator are arranged in the region that the transfer member surrounds, by the in vivo space of the shell
It is divided into first portion and second portion.
2. novel cell incubator according to claim 1, it is characterised in that：The guide rail is arc.
3. novel cell incubator according to claim 2, it is characterised in that：The guide rail is formed at rotating wheel.
4. novel cell incubator according to claim 1, it is characterised in that：The central axis of the transfer member of rotation hangs down
The plane directly formed in the bracket of rotation, alternatively, the central axis upright of the transfer member rotated is in bracket.
5. novel cell incubator according to claim 4, it is characterised in that：The bracket is rotationally set by shaft
It puts in the side of the transfer member, the shaft and the centerline axis parallel.
6. novel cell incubator according to claim 1, it is characterised in that：The separator includes：
Fixed part；
Movable part, the movable part are separately positioned on the opposite both ends of the fixed part, and in fixed part and
Between transfer member；The movable part has the bending part extended along the transfer member moving direction.
7. the cell manipulation platform of the novel cell incubator according to claim 1-6, the cell manipulation platform includes table top；
It is characterized in that：The cell manipulation platform further comprises：
Stent, the stent are arranged under the table top, have the first supporting item and the second supporting item on the stent so that
When first supporting item carries the housing, the outlet is not less than the table top, when second supporting item carries the housing,
The outlet is not higher than the table top；
The opening separately set, the opening separately set is arranged on the table top, suitable for passing through for the housing.
8. the cell manipulation platform according to claim, it is characterised in that：The cell manipulation platform further comprises：
Chamber door, the chamber door are arranged on the opening of the table top.
9. cell manipulation platform according to claim 7, it is characterised in that：The supporting item is hasp.
10. according to the method for work of any cell manipulation platforms of claim 7-9, the method for work includes following step
Suddenly：
(A1) housing is promoted, the second supporting item carries the housing so that the opening of housing is not less than the table top；
(A2) transfer member rotates in a ring on guide rail；
(A3) bracket corresponding with the culture dish selected is as the transfer member is mobile and is exposed to the opening of the housing；
(A4) culture dish of selection is taken out；
(A5) housing declines, and the first supporting item carries the housing so that the opening of housing is not higher than the table top.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711493009.0A CN108048322A (en) | 2017-12-31 | 2017-12-31 | Novel cell incubator, cell manipulation platform and its method of work |
| PCT/CN2018/125436 WO2019129268A1 (en) | 2017-12-31 | 2018-12-29 | Novel cell incubator, cell manipulation bench and method for operating same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711493009.0A CN108048322A (en) | 2017-12-31 | 2017-12-31 | Novel cell incubator, cell manipulation platform and its method of work |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108048322A true CN108048322A (en) | 2018-05-18 |
Family
ID=62129390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711493009.0A Pending CN108048322A (en) | 2017-12-31 | 2017-12-31 | Novel cell incubator, cell manipulation platform and its method of work |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108048322A (en) |
| WO (1) | WO2019129268A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113366099A (en) * | 2018-12-21 | 2021-09-07 | 奥克泰生物科技股份有限公司 | Carousel for modular bio-production units |
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|---|---|---|---|---|
| EP0429030A2 (en) * | 1989-11-21 | 1991-05-29 | BEHRINGWERKE Aktiengesellschaft | Incubator for microtitration plates |
| EP0717284A1 (en) * | 1994-12-12 | 1996-06-19 | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. | Chain incubator/conveyor and method of use |
| AT3118U1 (en) * | 1998-10-29 | 1999-10-25 | Pointner Josef | INCUBATOR WITH CIRCULAR ELEVATOR |
| US6228636B1 (en) * | 1998-09-21 | 2001-05-08 | Matsushita Electric Industrial Co., Ltd. | Incubator |
| CN105112283A (en) * | 2015-07-23 | 2015-12-02 | 中国科学院广州生物医药与健康研究院 | Incubator, and incubator door body automatic open-close method |
| CN205710765U (en) * | 2016-03-02 | 2016-11-23 | 苏州大学 | A kind of drawing and pulling type cell culture incubator |
| CN106591124A (en) * | 2016-12-21 | 2017-04-26 | 中国人民解放军总医院 | Cell culture apparatus |
| US20170327782A1 (en) * | 2015-02-05 | 2017-11-16 | Olympus Corporation | Cell-culturing apparatus |
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|---|---|---|---|---|
| EP3228694A1 (en) * | 2016-04-04 | 2017-10-11 | Clever Culture Systems AG | Input/output system for automatically supplying petri dishes to a processing stage and a carrier for manually supplying petri dishes to an input/output system |
| CN206666557U (en) * | 2017-02-27 | 2017-11-24 | 上海积发生物科技有限公司 | Combined type intelligent integral incubator |
-
2017
- 2017-12-31 CN CN201711493009.0A patent/CN108048322A/en active Pending
-
2018
- 2018-12-29 WO PCT/CN2018/125436 patent/WO2019129268A1/en active Application Filing
Patent Citations (8)
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|---|---|---|---|---|
| EP0429030A2 (en) * | 1989-11-21 | 1991-05-29 | BEHRINGWERKE Aktiengesellschaft | Incubator for microtitration plates |
| EP0717284A1 (en) * | 1994-12-12 | 1996-06-19 | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. | Chain incubator/conveyor and method of use |
| US6228636B1 (en) * | 1998-09-21 | 2001-05-08 | Matsushita Electric Industrial Co., Ltd. | Incubator |
| AT3118U1 (en) * | 1998-10-29 | 1999-10-25 | Pointner Josef | INCUBATOR WITH CIRCULAR ELEVATOR |
| US20170327782A1 (en) * | 2015-02-05 | 2017-11-16 | Olympus Corporation | Cell-culturing apparatus |
| CN105112283A (en) * | 2015-07-23 | 2015-12-02 | 中国科学院广州生物医药与健康研究院 | Incubator, and incubator door body automatic open-close method |
| CN205710765U (en) * | 2016-03-02 | 2016-11-23 | 苏州大学 | A kind of drawing and pulling type cell culture incubator |
| CN106591124A (en) * | 2016-12-21 | 2017-04-26 | 中国人民解放军总医院 | Cell culture apparatus |
Non-Patent Citations (1)
| Title |
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| 周梦怡;勇强;徐莉;: "细胞培养无菌技术及有效控制污染的措施", vol. 32, no. 04, pages 477 - 479 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113366099A (en) * | 2018-12-21 | 2021-09-07 | 奥克泰生物科技股份有限公司 | Carousel for modular bio-production units |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019129268A1 (en) | 2019-07-04 |
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Effective date of registration: 20201217 Address after: Area a, 4th floor, no.483, Xingnan Avenue, Nancun Town, Panyu District, Guangzhou City, Guangdong Province Applicant after: Guangzhou aibeitai Biotechnology Co.,Ltd. Applicant after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Applicant before: CHINA INNOVATION INSTRUMENT Co.,Ltd. |
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Effective date of registration: 20220311 Address after: 510535 floor 1, building C2, No. 11, Kaiyuan Avenue, Huangpu District, Guangzhou, Guangdong Applicant after: GUANGZHOU HUAYUEHANG MEDICAL TECHNOLOGY Co.,Ltd. Address before: Area a, 4th floor, no.483, Xingnan Avenue, Nancun Town, Panyu District, Guangzhou City, Guangdong Province Applicant before: Guangzhou aibeitai Biotechnology Co.,Ltd. Applicant before: Ningbo Huayi ningchuang Intelligent Technology Co., Ltd |
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